

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | hemidesmosome assembly (GO:0031581) | 8.74724260 |
| 2 | peptide cross-linking (GO:0018149) | 7.96364219 |
| 3 | multicellular organismal water homeostasis (GO:0050891) | 7.33983101 |
| 4 | keratinocyte differentiation (GO:0030216) | 7.32897503 |
| 5 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 6.26372269 |
| 6 | water homeostasis (GO:0030104) | 6.08995183 |
| 7 | intermediate filament organization (GO:0045109) | 6.03187420 |
| 8 | epidermis development (GO:0008544) | 5.79587927 |
| 9 | epidermal cell differentiation (GO:0009913) | 5.75529413 |
| 10 | thyroid hormone generation (GO:0006590) | 5.40084284 |
| 11 | vitamin A metabolic process (GO:0006776) | 5.38519338 |
| 12 | skin morphogenesis (GO:0043589) | 5.16004901 |
| 13 | keratinocyte proliferation (GO:0043616) | 5.07154088 |
| 14 | gap junction assembly (GO:0016264) | 4.96119512 |
| 15 | lymph vessel development (GO:0001945) | 4.59789718 |
| 16 | lateral sprouting from an epithelium (GO:0060601) | 4.59741720 |
| 17 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 4.59005840 |
| 18 | negative regulation of keratinocyte proliferation (GO:0010839) | 4.37287292 |
| 19 | thyroid hormone metabolic process (GO:0042403) | 4.35936159 |
| 20 | polarized epithelial cell differentiation (GO:0030859) | 4.30337355 |
| 21 | virion attachment to host cell (GO:0019062) | 4.25701839 |
| 22 | adhesion of symbiont to host cell (GO:0044650) | 4.25701839 |
| 23 | hair follicle morphogenesis (GO:0031069) | 4.21456045 |
| 24 | regulation of keratinocyte differentiation (GO:0045616) | 3.94772758 |
| 25 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 3.91133113 |
| 26 | regulation of ruffle assembly (GO:1900027) | 3.90760031 |
| 27 | ectoderm development (GO:0007398) | 3.90012230 |
| 28 | intermediate filament cytoskeleton organization (GO:0045104) | 3.82688674 |
| 29 | cell wall macromolecule catabolic process (GO:0016998) | 3.82144735 |
| 30 | cell wall macromolecule metabolic process (GO:0044036) | 3.82144735 |
| 31 | long-chain fatty acid biosynthetic process (GO:0042759) | 3.77037802 |
| 32 | intermediate filament-based process (GO:0045103) | 3.69799810 |
| 33 | positive regulation of hair follicle development (GO:0051798) | 3.57063602 |
| 34 | positive regulation of hair cycle (GO:0042635) | 3.57063602 |
| 35 | positive regulation of keratinocyte differentiation (GO:0045618) | 3.48466036 |
| 36 | negative regulation of epidermis development (GO:0045683) | 3.45206431 |
| 37 | keratinocyte development (GO:0003334) | 3.44140265 |
| 38 | cell adhesion mediated by integrin (GO:0033627) | 3.42216112 |
| 39 | surfactant homeostasis (GO:0043129) | 3.41640611 |
| 40 | retinal metabolic process (GO:0042574) | 3.40394529 |
| 41 | negative regulation of cell fate specification (GO:0009996) | 3.39865532 |
| 42 | outer ear morphogenesis (GO:0042473) | 3.39363945 |
| 43 | negative regulation of cell fate commitment (GO:0010454) | 3.37028697 |
| 44 | adhesion of symbiont to host (GO:0044406) | 3.35487575 |
| 45 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.26769662 |
| 46 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.24836166 |
| 47 | hair cycle process (GO:0022405) | 3.22841148 |
| 48 | molting cycle process (GO:0022404) | 3.22841148 |
| 49 | regulation of hair follicle development (GO:0051797) | 3.22521161 |
| 50 | membrane tubulation (GO:0097320) | 3.20723206 |
| 51 | endodermal cell differentiation (GO:0035987) | 3.19963422 |
| 52 | negative regulation of stress fiber assembly (GO:0051497) | 3.18722350 |
| 53 | positive regulation of epidermis development (GO:0045684) | 3.15474120 |
| 54 | gland morphogenesis (GO:0022612) | 3.13788655 |
| 55 | regulation of cardioblast differentiation (GO:0051890) | 3.11534141 |
| 56 | regulation of epidermis development (GO:0045682) | 3.10097949 |
| 57 | regulation of skeletal muscle contraction (GO:0014819) | 3.09194586 |
| 58 | sphingoid metabolic process (GO:0046519) | 3.07378050 |
| 59 | chemical homeostasis within a tissue (GO:0048875) | 3.06740483 |
| 60 | glucosamine-containing compound catabolic process (GO:1901072) | 3.02107098 |
| 61 | cell-substrate junction assembly (GO:0007044) | 3.02094997 |
| 62 | regulation of phospholipase A2 activity (GO:0032429) | 3.01546013 |
| 63 | negative regulation of interferon-gamma production (GO:0032689) | 2.98440385 |
| 64 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.96851647 |
| 65 | one-carbon compound transport (GO:0019755) | 2.95409441 |
| 66 | retinol metabolic process (GO:0042572) | 2.94077980 |
| 67 | regulation of epidermal cell differentiation (GO:0045604) | 2.93069978 |
| 68 | embryonic viscerocranium morphogenesis (GO:0048703) | 2.91913725 |
| 69 | epithelium development (GO:0060429) | 2.90799384 |
| 70 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.90673397 |
| 71 | cell communication involved in cardiac conduction (GO:0086065) | 2.89955034 |
| 72 | cell junction assembly (GO:0034329) | 2.89301646 |
| 73 | skin development (GO:0043588) | 2.89167896 |
| 74 | linoleic acid metabolic process (GO:0043651) | 2.88420559 |
| 75 | atrioventricular valve morphogenesis (GO:0003181) | 2.86075103 |
| 76 | protein localization to endosome (GO:0036010) | 2.83897976 |
| 77 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.83543828 |
| 78 | cell junction organization (GO:0034330) | 2.83218761 |
| 79 | fatty acid elongation (GO:0030497) | 2.83154605 |
| 80 | regulation of cardioblast proliferation (GO:0003264) | 2.82153239 |
| 81 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 2.82153239 |
| 82 | epithelial cell-cell adhesion (GO:0090136) | 2.81953383 |
| 83 | detection of bacterium (GO:0016045) | 2.80615110 |
| 84 | sphingosine metabolic process (GO:0006670) | 2.75933102 |
| 85 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 2.72172606 |
| 86 | mammary gland development (GO:0030879) | 2.70331697 |
| 87 | non-canonical Wnt signaling pathway (GO:0035567) | 2.69785489 |
| 88 | mesodermal cell differentiation (GO:0048333) | 2.69284706 |
| 89 | ventricular cardiac muscle cell action potential (GO:0086005) | 2.69255106 |
| 90 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.68916223 |
| 91 | tooth mineralization (GO:0034505) | 2.68679023 |
| 92 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.65281130 |
| 93 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 2.63881964 |
| 94 | hypotonic response (GO:0006971) | 2.63818837 |
| 95 | hair follicle development (GO:0001942) | 2.63450825 |
| 96 | thyroid gland development (GO:0030878) | 2.63030001 |
| 97 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.62846355 |
| 98 | regulation of hair cycle (GO:0042634) | 2.62331716 |
| 99 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 2.62166304 |
| 100 | establishment of planar polarity (GO:0001736) | 2.62151233 |
| 101 | establishment of tissue polarity (GO:0007164) | 2.62151233 |
| 102 | regulation of T cell chemotaxis (GO:0010819) | 2.60687115 |
| 103 | positive regulation of T cell chemotaxis (GO:0010820) | 2.60687115 |
| 104 | regulation of apoptotic process involved in morphogenesis (GO:1902337) | 2.60511734 |
| 105 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.60015225 |
| 106 | lipoxygenase pathway (GO:0019372) | 2.59893236 |
| 107 | regulation of keratinocyte proliferation (GO:0010837) | 2.57480678 |
| 108 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.57327510 |
| 109 | phospholipid scrambling (GO:0017121) | 2.57183636 |
| 110 | coronary vasculature morphogenesis (GO:0060977) | 2.56532206 |
| 111 | muscle organ morphogenesis (GO:0048644) | 2.56189819 |
| 112 | odontogenesis (GO:0042476) | 2.56038724 |
| 113 | positive regulation of epidermal cell differentiation (GO:0045606) | 2.55700957 |
| 114 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.55668981 |
| 115 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.53953934 |
| 116 | renal filtration (GO:0097205) | 2.52445604 |
| 117 | positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745) | 2.52251299 |
| 118 | wound healing (GO:0042060) | 2.50369265 |
| 119 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 2.44253106 |
| 120 | diol metabolic process (GO:0034311) | 2.43166887 |
| 121 | regulation of natural killer cell differentiation (GO:0032823) | 2.42203832 |
| 122 | renal system development (GO:0072001) | 2.42179264 |
| 123 | regulation of glomerular filtration (GO:0003093) | 2.41106912 |
| 124 | regulation of skeletal muscle cell differentiation (GO:2001014) | 2.40992362 |
| 125 | detection of other organism (GO:0098543) | 2.40750938 |
| 126 | extracellular matrix disassembly (GO:0022617) | 2.39933929 |
| 127 | regulation of fibroblast apoptotic process (GO:2000269) | 2.38277736 |
| 128 | negative regulation of stem cell proliferation (GO:2000647) | 2.36824049 |
| 129 | cardiac right ventricle morphogenesis (GO:0003215) | 2.36549118 |
| 130 | response to vitamin D (GO:0033280) | 2.36513825 |
| 131 | filopodium assembly (GO:0046847) | 2.36307643 |
| 132 | epithelial cell proliferation (GO:0050673) | 2.35946386 |
| 133 | intestinal epithelial cell development (GO:0060576) | 2.34001436 |
| 134 | genitalia morphogenesis (GO:0035112) | 2.32824738 |
| 135 | mitotic G1/S transition checkpoint (GO:0044819) | 2.32491519 |
| 136 | keratinization (GO:0031424) | 15.1137989 |
| 137 | desmosome organization (GO:0002934) | 11.9295388 |
| 138 | establishment of skin barrier (GO:0061436) | 11.5371871 |
| 139 | molting cycle (GO:0042303) | 10.9839458 |
| 140 | hair cycle (GO:0042633) | 10.9839458 |
| 141 | regulation of water loss via skin (GO:0033561) | 10.3511229 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 5.17176408 |
| 2 | * SOX9_24532713_ChIP-Seq_HFSC_Mouse | 2.94228092 |
| 3 | * P63_26484246_Chip-Seq_KERATINOCYTES_Human | 2.76950560 |
| 4 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.65315427 |
| 5 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.58321448 |
| 6 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.38752076 |
| 7 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.37292669 |
| 8 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.22682539 |
| 9 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 2.20638701 |
| 10 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 12.5498714 |
| 11 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.96844109 |
| 12 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.91830436 |
| 13 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.82028219 |
| 14 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.82028219 |
| 15 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.79084513 |
| 16 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.77181779 |
| 17 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.76320407 |
| 18 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.70028238 |
| 19 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.53773404 |
| 20 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.50225945 |
| 21 | CJUN_26792858_Chip-Seq_BT549_Human | 1.44497069 |
| 22 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.41562701 |
| 23 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.41462767 |
| 24 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.39902120 |
| 25 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.37793690 |
| 26 | * TP63_23658742_ChIP-Seq_EP156T_Human | 1.36823228 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.36703802 |
| 28 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.29509382 |
| 29 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.28381340 |
| 30 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.27714150 |
| 31 | * TP63_22573176_ChIP-Seq_HFKS_Human | 1.25233874 |
| 32 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.21943764 |
| 33 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.20894950 |
| 34 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.17720985 |
| 35 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.17266913 |
| 36 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.17195156 |
| 37 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.16833354 |
| 38 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.13391460 |
| 39 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.12868837 |
| 40 | * CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.11886671 |
| 41 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.10612525 |
| 42 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.10253838 |
| 43 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.10096254 |
| 44 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.09740407 |
| 45 | RXR_22108803_ChIP-Seq_LS180_Human | 1.06295771 |
| 46 | ATF3_27146783_Chip-Seq_COLON_Human | 1.06282078 |
| 47 | * P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.05716026 |
| 48 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.05700737 |
| 49 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.05291210 |
| 50 | * GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.04777387 |
| 51 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.03920813 |
| 52 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.03236573 |
| 53 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.03107628 |
| 54 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.02711005 |
| 55 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.02438764 |
| 56 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.02030262 |
| 57 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.01887785 |
| 58 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.01866784 |
| 59 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.00530895 |
| 60 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.98702996 |
| 61 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97870762 |
| 62 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.96206509 |
| 63 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.95867754 |
| 64 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.95490780 |
| 65 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.95490780 |
| 66 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.94984137 |
| 67 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.94977744 |
| 68 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.94956387 |
| 69 | * CTCF_20526341_ChIP-Seq_ESCs_Human | 0.94777236 |
| 70 | * GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.94563980 |
| 71 | TP53_16413492_ChIP-PET_HCT116_Human | 0.94417592 |
| 72 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.93653170 |
| 73 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.92078081 |
| 74 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.90200857 |
| 75 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.90174792 |
| 76 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.89774948 |
| 77 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.88591292 |
| 78 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.86947953 |
| 79 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.86511591 |
| 80 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.86470300 |
| 81 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.85944100 |
| 82 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.85738047 |
| 83 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.84929640 |
| 84 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.84344982 |
| 85 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.84307890 |
| 86 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.83804249 |
| 87 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.82017496 |
| 88 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.79671919 |
| 89 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.79434043 |
| 90 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.78517686 |
| 91 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.78264175 |
| 92 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78186962 |
| 93 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.78179177 |
| 94 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.76904484 |
| 95 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.76904484 |
| 96 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.76273663 |
| 97 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.75953424 |
| 98 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.75801962 |
| 99 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.75367909 |
| 100 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.75300994 |
| 101 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.74873712 |
| 102 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.74811273 |
| 103 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.74365441 |
| 104 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.73806663 |
| 105 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.73552328 |
| 106 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.73192516 |
| 107 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.71713286 |
| 108 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.71025319 |
| 109 | KDM2B_26808549_Chip-Seq_K562_Human | 0.70820885 |
| 110 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.70738064 |
| 111 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.68268896 |
| 112 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.65947877 |
| 113 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.64605101 |
| 114 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.62833970 |
| 115 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.61627100 |
| 116 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.59766619 |
| 117 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.59329507 |
| 118 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.57740227 |
| 119 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.55757265 |
| 120 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.55029457 |
| 121 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.54695665 |
| 122 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.53926479 |
| 123 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.53877082 |
| 124 | * HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.53450036 |
| 125 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.53325147 |
| 126 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.52319435 |
| 127 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.52290728 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002796_impaired_skin_barrier | 7.34010117 |
| 2 | MP0005275_abnormal_skin_tensile | 5.85894173 |
| 3 | MP0010234_abnormal_vibrissa_follicle | 5.54558948 |
| 4 | MP0000579_abnormal_nail_morphology | 4.45183186 |
| 5 | MP0005501_abnormal_skin_physiology | 4.43087987 |
| 6 | MP0002098_abnormal_vibrissa_morphology | 3.40841543 |
| 7 | MP0000383_abnormal_hair_follicle | 3.40488462 |
| 8 | MP0010678_abnormal_skin_adnexa | 3.36566493 |
| 9 | MP0003941_abnormal_skin_development | 3.22104194 |
| 10 | MP0002060_abnormal_skin_morphology | 3.19337692 |
| 11 | MP0002254_reproductive_system_inflammat | 3.15776428 |
| 12 | MP0003705_abnormal_hypodermis_morpholog | 3.13744320 |
| 13 | MP0000647_abnormal_sebaceous_gland | 3.04927767 |
| 14 | MP0001216_abnormal_epidermal_layer | 3.04724487 |
| 15 | MP0004381_abnormal_hair_follicle | 2.98278594 |
| 16 | MP0010771_integument_phenotype | 2.79382341 |
| 17 | MP0003011_delayed_dark_adaptation | 2.76112763 |
| 18 | MP0000377_abnormal_hair_follicle | 2.64865117 |
| 19 | MP0000427_abnormal_hair_cycle | 2.56488695 |
| 20 | MP0004947_skin_inflammation | 2.41971151 |
| 21 | MP0003453_abnormal_keratinocyte_physiol | 2.35723139 |
| 22 | MP0000467_abnormal_esophagus_morphology | 2.32598453 |
| 23 | MP0000762_abnormal_tongue_morphology | 2.23858632 |
| 24 | MP0005451_abnormal_body_composition | 2.20724398 |
| 25 | MP0002234_abnormal_pharynx_morphology | 2.17381313 |
| 26 | MP0003566_abnormal_cell_adhesion | 2.03510062 |
| 27 | MP0001346_abnormal_lacrimal_gland | 1.78055942 |
| 28 | MP0001243_abnormal_dermal_layer | 1.62497687 |
| 29 | MP0009931_abnormal_skin_appearance | 1.57163350 |
| 30 | MP0000678_abnormal_parathyroid_gland | 1.52710304 |
| 31 | MP0000367_abnormal_coat/_hair | 1.48020589 |
| 32 | MP0001191_abnormal_skin_condition | 1.34954631 |
| 33 | MP0005075_abnormal_melanosome_morpholog | 1.27639055 |
| 34 | MP0000566_synostosis | 1.27363274 |
| 35 | MP0004185_abnormal_adipocyte_glucose | 1.18183586 |
| 36 | MP0002249_abnormal_larynx_morphology | 1.13888728 |
| 37 | MP0002009_preneoplasia | 1.12548248 |
| 38 | MP0000537_abnormal_urethra_morphology | 1.11351636 |
| 39 | MP0000681_abnormal_thyroid_gland | 1.10153678 |
| 40 | MP0001851_eye_inflammation | 1.09509340 |
| 41 | MP0004019_abnormal_vitamin_homeostasis | 1.05468577 |
| 42 | MP0001849_ear_inflammation | 1.01832748 |
| 43 | MP0010030_abnormal_orbit_morphology | 1.01544529 |
| 44 | MP0002095_abnormal_skin_pigmentation | 0.99352376 |
| 45 | MP0005377_hearing/vestibular/ear_phenot | 0.96856498 |
| 46 | MP0003878_abnormal_ear_physiology | 0.96856498 |
| 47 | MP0009053_abnormal_anal_canal | 0.94420598 |
| 48 | MP0003191_abnormal_cellular_cholesterol | 0.93121656 |
| 49 | MP0004272_abnormal_basement_membrane | 0.90219464 |
| 50 | MP0005394_taste/olfaction_phenotype | 0.89245176 |
| 51 | MP0005499_abnormal_olfactory_system | 0.89245176 |
| 52 | MP0000465_gastrointestinal_hemorrhage | 0.86002062 |
| 53 | MP0001340_abnormal_eyelid_morphology | 0.83640589 |
| 54 | MP0008260_abnormal_autophagy | 0.83455538 |
| 55 | MP0002282_abnormal_trachea_morphology | 0.83276597 |
| 56 | MP0008438_abnormal_cutaneous_collagen | 0.83086217 |
| 57 | MP0006054_spinal_hemorrhage | 0.80999747 |
| 58 | MP0003763_abnormal_thymus_physiology | 0.80415920 |
| 59 | MP0005257_abnormal_intraocular_pressure | 0.77773338 |
| 60 | MP0000516_abnormal_urinary_system | 0.71503643 |
| 61 | MP0005367_renal/urinary_system_phenotyp | 0.71503643 |
| 62 | MP0003136_yellow_coat_color | 0.71144458 |
| 63 | MP0003755_abnormal_palate_morphology | 0.71031569 |
| 64 | MP0005023_abnormal_wound_healing | 0.69856843 |
| 65 | MP0010352_gastrointestinal_tract_polyps | 0.67916557 |
| 66 | MP0005508_abnormal_skeleton_morphology | 0.64789305 |
| 67 | MP0000372_irregular_coat_pigmentation | 0.64698447 |
| 68 | MP0002177_abnormal_outer_ear | 0.63345018 |
| 69 | MP0002877_abnormal_melanocyte_morpholog | 0.62608352 |
| 70 | MP0009384_cardiac_valve_regurgitation | 0.60529463 |
| 71 | MP0009250_abnormal_appendicular_skeleto | 0.59888837 |
| 72 | MP0005409_darkened_coat_color | 0.59469067 |
| 73 | MP0000627_abnormal_mammary_gland | 0.59365898 |
| 74 | MP0001784_abnormal_fluid_regulation | 0.59360228 |
| 75 | MP0004782_abnormal_surfactant_physiolog | 0.58514633 |
| 76 | MP0002896_abnormal_bone_mineralization | 0.57160773 |
| 77 | MP0000858_altered_metastatic_potential | 0.55827263 |
| 78 | MP0002233_abnormal_nose_morphology | 0.54474841 |
| 79 | MP0004264_abnormal_extraembryonic_tissu | 0.53046020 |
| 80 | MP0003315_abnormal_perineum_morphology | 0.52507743 |
| 81 | MP0003300_gastrointestinal_ulcer | 0.51820962 |
| 82 | MP0001188_hyperpigmentation | 0.50595448 |
| 83 | MP0001299_abnormal_eye_distance/ | 0.46494157 |
| 84 | MP0001879_abnormal_lymphatic_vessel | 0.46235662 |
| 85 | MP0000462_abnormal_digestive_system | 0.44842378 |
| 86 | MP0000015_abnormal_ear_pigmentation | 0.43003650 |
| 87 | MP0009379_abnormal_foot_pigmentation | 0.42519250 |
| 88 | MP0005076_abnormal_cell_differentiation | 0.42361933 |
| 89 | MP0008789_abnormal_olfactory_epithelium | 0.42287915 |
| 90 | MP0005623_abnormal_meninges_morphology | 0.42159612 |
| 91 | MP0009780_abnormal_chondrocyte_physiolo | 0.40654584 |
| 92 | MP0002090_abnormal_vision | 0.40575705 |
| 93 | MP0004885_abnormal_endolymph | 0.39593006 |
| 94 | MP0005666_abnormal_adipose_tissue | 0.39279263 |
| 95 | MP0000751_myopathy | 0.39253632 |
| 96 | MP0000470_abnormal_stomach_morphology | 0.37547670 |
| 97 | MP0000049_abnormal_middle_ear | 0.37474544 |
| 98 | MP0003828_pulmonary_edema | 0.36628783 |
| 99 | MP0005193_abnormal_anterior_eye | 0.36145633 |
| 100 | MP0006138_congestive_heart_failure | 0.34236676 |
| 101 | MP0005375_adipose_tissue_phenotype | 0.33945476 |
| 102 | MP0000432_abnormal_head_morphology | 0.32997905 |
| 103 | MP0002166_altered_tumor_susceptibility | 0.32944363 |
| 104 | MP0001661_extended_life_span | 0.31649415 |
| 105 | MP0003045_fibrosis | 0.31467704 |
| 106 | MP0003935_abnormal_craniofacial_develop | 0.31453412 |
| 107 | MP0002108_abnormal_muscle_morphology | 0.31286502 |
| 108 | MP0000538_abnormal_urinary_bladder | 0.31169569 |
| 109 | MP0001270_distended_abdomen | 0.31005671 |
| 110 | MP0002133_abnormal_respiratory_system | 0.30364064 |
| 111 | MP0005388_respiratory_system_phenotype | 0.30364064 |
| 112 | MP0001958_emphysema | 0.30090420 |
| 113 | MP0002111_abnormal_tail_morphology | 0.29906797 |
| 114 | MP0003385_abnormal_body_wall | 0.29154289 |
| 115 | MP0000750_abnormal_muscle_regeneration | 0.28205782 |
| 116 | MP0005174_abnormal_tail_pigmentation | 0.27142207 |
| 117 | MP0005503_abnormal_tendon_morphology | 0.26996484 |
| 118 | MP0002089_abnormal_postnatal_growth/wei | 0.26070449 |
| 119 | MP0010368_abnormal_lymphatic_system | 0.25696363 |
| 120 | MP0000685_abnormal_immune_system | 0.25428835 |
| 121 | MP0001324_abnormal_eye_pigmentation | 0.25066774 |
| 122 | MP0005166_decreased_susceptibility_to | 0.24858925 |
| 123 | MP0005390_skeleton_phenotype | 0.24269966 |
| 124 | MP0002092_abnormal_eye_morphology | 0.23962642 |
| 125 | MP0005360_urolithiasis | 0.23109662 |
| 126 | MP0003638_abnormal_response/metabolism_ | 0.22564470 |
| 127 | MP0004858_abnormal_nervous_system | 0.21396144 |
| 128 | MP0009840_abnormal_foam_cell | 0.20398195 |
| 129 | MP0002006_tumorigenesis | 0.18495495 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased IgE level (HP:0003212) | 8.12739981 |
| 2 | Hypotrichosis (HP:0001006) | 7.90482802 |
| 3 | Pili torti (HP:0003777) | 6.98397302 |
| 4 | Onycholysis (HP:0001806) | 6.78600525 |
| 5 | Woolly hair (HP:0002224) | 6.57950798 |
| 6 | Plantar hyperkeratosis (HP:0007556) | 6.32323457 |
| 7 | Right ventricular cardiomyopathy (HP:0011663) | 6.14717590 |
| 8 | Fragile nails (HP:0001808) | 5.98403439 |
| 9 | Abnormality of nail color (HP:0100643) | 5.92673283 |
| 10 | Palmoplantar hyperkeratosis (HP:0000972) | 5.67827911 |
| 11 | Palmar hyperkeratosis (HP:0010765) | 5.32603810 |
| 12 | Congenital ichthyosiform erythroderma (HP:0007431) | 5.07278593 |
| 13 | Milia (HP:0001056) | 4.56294602 |
| 14 | Abnormality of secondary sexual hair (HP:0009888) | 4.55406124 |
| 15 | Abnormality of the axillary hair (HP:0100134) | 4.55406124 |
| 16 | Conjunctival hamartoma (HP:0100780) | 4.55390577 |
| 17 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 4.50579313 |
| 18 | Erythema (HP:0010783) | 4.49498603 |
| 19 | Erythroderma (HP:0001019) | 4.39750455 |
| 20 | Abnormal hair laboratory examination (HP:0003328) | 4.34137813 |
| 21 | Nail dystrophy (HP:0008404) | 4.14975498 |
| 22 | Absent eyelashes (HP:0000561) | 3.84904455 |
| 23 | Abnormal blistering of the skin (HP:0008066) | 3.82082961 |
| 24 | Thick nail (HP:0001805) | 3.77335681 |
| 25 | Oral leukoplakia (HP:0002745) | 3.64069954 |
| 26 | Parakeratosis (HP:0001036) | 3.62723547 |
| 27 | Alopecia of scalp (HP:0002293) | 3.38395874 |
| 28 | Atrophic scars (HP:0001075) | 3.20362132 |
| 29 | Hyporeflexia of lower limbs (HP:0002600) | 3.14930584 |
| 30 | Distal lower limb muscle weakness (HP:0009053) | 3.13799985 |
| 31 | Lip pit (HP:0100267) | 3.11235622 |
| 32 | Corneal erosion (HP:0200020) | 3.06143315 |
| 33 | Dry hair (HP:0011359) | 3.03385228 |
| 34 | Selective tooth agenesis (HP:0001592) | 2.96471668 |
| 35 | Advanced eruption of teeth (HP:0006288) | 2.91189486 |
| 36 | Absent hair (HP:0002298) | 2.90461962 |
| 37 | Natal tooth (HP:0000695) | 2.87702849 |
| 38 | Abnormality of the salivary glands (HP:0010286) | 2.87189713 |
| 39 | Ectropion (HP:0000656) | 2.83169360 |
| 40 | Palmoplantar keratoderma (HP:0000982) | 2.80660998 |
| 41 | Type 1 muscle fiber predominance (HP:0003803) | 2.80348900 |
| 42 | Sparse eyelashes (HP:0000653) | 2.77134464 |
| 43 | Hamartoma of the eye (HP:0010568) | 2.74307756 |
| 44 | Increased connective tissue (HP:0009025) | 2.74106662 |
| 45 | Ventricular tachycardia (HP:0004756) | 2.74038096 |
| 46 | Brittle hair (HP:0002299) | 2.73369298 |
| 47 | Acanthosis nigricans (HP:0000956) | 2.72574652 |
| 48 | Gangrene (HP:0100758) | 2.70744140 |
| 49 | Oligodontia (HP:0000677) | 2.67030668 |
| 50 | Hypohidrosis (HP:0000966) | 2.60826357 |
| 51 | Hypoplastic labia majora (HP:0000059) | 2.60250656 |
| 52 | Amniotic constriction ring (HP:0009775) | 2.58954127 |
| 53 | Abnormality of placental membranes (HP:0011409) | 2.58954127 |
| 54 | Follicular hyperkeratosis (HP:0007502) | 2.58811768 |
| 55 | Curly hair (HP:0002212) | 2.58195278 |
| 56 | Pruritus (HP:0000989) | 2.52621609 |
| 57 | Anonychia (HP:0001798) | 2.50912978 |
| 58 | Distal arthrogryposis (HP:0005684) | 2.45317685 |
| 59 | Popliteal pterygium (HP:0009756) | 2.42482697 |
| 60 | Round ear (HP:0100830) | 2.42042988 |
| 61 | Corneal dystrophy (HP:0001131) | 2.37028272 |
| 62 | Double outlet right ventricle (HP:0001719) | 2.35590960 |
| 63 | Congenital malformation of the right heart (HP:0011723) | 2.35590960 |
| 64 | Abnormality of the labia majora (HP:0012881) | 2.35399023 |
| 65 | Hypergammaglobulinemia (HP:0010702) | 2.30446902 |
| 66 | Carious teeth (HP:0000670) | 2.26536074 |
| 67 | Muscle fiber inclusion bodies (HP:0100299) | 2.25353196 |
| 68 | Ulnar deviation of the wrist (HP:0003049) | 2.25316578 |
| 69 | Ridged nail (HP:0001807) | 2.24305444 |
| 70 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.22879108 |
| 71 | Unilateral renal agenesis (HP:0000122) | 2.20998216 |
| 72 | Nemaline bodies (HP:0003798) | 2.18384836 |
| 73 | Eczematoid dermatitis (HP:0000976) | 2.15402331 |
| 74 | Ankyloglossia (HP:0010296) | 2.14774093 |
| 75 | Fatigable weakness (HP:0003473) | 2.12264322 |
| 76 | Abnormality of the neuromuscular junction (HP:0003398) | 2.12264322 |
| 77 | Sparse scalp hair (HP:0002209) | 2.09616687 |
| 78 | Xerostomia (HP:0000217) | 2.06695918 |
| 79 | Abnormality of the fingernails (HP:0001231) | 2.06247419 |
| 80 | Exercise-induced myalgia (HP:0003738) | 2.04893160 |
| 81 | Difficulty running (HP:0009046) | 2.04380837 |
| 82 | Down-sloping shoulders (HP:0200021) | 2.02683165 |
| 83 | Hyperthyroidism (HP:0000836) | 2.01651308 |
| 84 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.99528126 |
| 85 | Tetany (HP:0001281) | 1.98870943 |
| 86 | Slow-growing hair (HP:0002217) | 1.97802881 |
| 87 | Abnormality of hair growth rate (HP:0011363) | 1.97802881 |
| 88 | Hypoplasia of dental enamel (HP:0006297) | 1.97598271 |
| 89 | Hypodontia (HP:0000668) | 1.96627380 |
| 90 | Bronchomalacia (HP:0002780) | 1.95511268 |
| 91 | Fragile skin (HP:0001030) | 1.94247716 |
| 92 | Skin ulcer (HP:0200042) | 1.94112411 |
| 93 | Myopathic facies (HP:0002058) | 1.93841277 |
| 94 | Concave nail (HP:0001598) | 1.90869063 |
| 95 | Fine hair (HP:0002213) | 1.89500032 |
| 96 | Muscle fiber splitting (HP:0003555) | 1.87906744 |
| 97 | Ventricular fibrillation (HP:0001663) | 1.87842236 |
| 98 | Nasolacrimal duct obstruction (HP:0000579) | 1.85502654 |
| 99 | Aplasia cutis congenita (HP:0001057) | 1.85310484 |
| 100 | Septate vagina (HP:0001153) | 1.83544199 |
| 101 | Multifactorial inheritance (HP:0001426) | 1.82833193 |
| 102 | Absent phalangeal crease (HP:0006109) | 1.82492200 |
| 103 | Abnormality of the gastric mucosa (HP:0004295) | 1.79841699 |
| 104 | Abnormality of the aortic arch (HP:0012303) | 1.77438499 |
| 105 | Laryngomalacia (HP:0001601) | 1.76808344 |
| 106 | Hypoparathyroidism (HP:0000829) | 1.76042917 |
| 107 | Neck muscle weakness (HP:0000467) | 1.75581660 |
| 108 | Squamous cell carcinoma (HP:0002860) | 1.74097194 |
| 109 | Congenital, generalized hypertrichosis (HP:0004540) | 1.73237539 |
| 110 | Calcaneovalgus deformity (HP:0001848) | 1.72905034 |
| 111 | Conical tooth (HP:0000698) | 1.72889292 |
| 112 | Pustule (HP:0200039) | 1.72053395 |
| 113 | Achilles tendon contracture (HP:0001771) | 1.71972483 |
| 114 | Areflexia of lower limbs (HP:0002522) | 1.70376580 |
| 115 | Abnormality of oral frenula (HP:0000190) | 1.69393750 |
| 116 | Split foot (HP:0001839) | 1.66070515 |
| 117 | Abnormality of permanent molar morphology (HP:0011071) | 1.65658114 |
| 118 | Abnormality of the dental root (HP:0006486) | 1.65658114 |
| 119 | Taurodontia (HP:0000679) | 1.65658114 |
| 120 | Hyperhidrosis (HP:0000975) | 1.61325188 |
| 121 | Scapular winging (HP:0003691) | 1.60420803 |
| 122 | Sudden death (HP:0001699) | 1.60342275 |
| 123 | Dehydration (HP:0001944) | 1.60170233 |
| 124 | Exercise-induced muscle cramps (HP:0003710) | 1.59241249 |
| 125 | Distal lower limb amyotrophy (HP:0008944) | 1.56987514 |
| 126 | Autoamputation (HP:0001218) | 1.56868789 |
| 127 | Blepharitis (HP:0000498) | 1.56427204 |
| 128 | Deformed tarsal bones (HP:0008119) | 1.56113612 |
| 129 | Melanocytic nevus (HP:0000995) | 1.56074111 |
| 130 | Breast hypoplasia (HP:0003187) | 1.55770724 |
| 131 | Abnormality of the Achilles tendon (HP:0005109) | 1.54704405 |
| 132 | Recurrent corneal erosions (HP:0000495) | 1.53814421 |
| 133 | Abnormality of molar morphology (HP:0011070) | 1.52816455 |
| 134 | Abnormality of molar (HP:0011077) | 1.52816455 |
| 135 | Amelogenesis imperfecta (HP:0000705) | 1.52292022 |
| 136 | Labial hypoplasia (HP:0000066) | 1.49997776 |
| 137 | Duplicated collecting system (HP:0000081) | 1.49395684 |
| 138 | Esophageal atresia (HP:0002032) | 1.49299654 |
| 139 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 1.49197515 |
| 140 | Furrowed tongue (HP:0000221) | 1.49069015 |
| 141 | Pterygium (HP:0001059) | 1.48343758 |
| 142 | Abnormality of the lacrimal duct (HP:0011481) | 1.48310586 |
| 143 | Increased variability in muscle fiber diameter (HP:0003557) | 1.48297916 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ARAF | 4.72896237 |
| 2 | EPHB2 | 4.71322707 |
| 3 | MAPKAPK3 | 4.50155270 |
| 4 | MST4 | 4.06876676 |
| 5 | MST1R | 3.89690007 |
| 6 | FER | 3.54494350 |
| 7 | TTN | 3.20757881 |
| 8 | LATS1 | 3.13701071 |
| 9 | TRPM7 | 2.44171033 |
| 10 | MAP3K3 | 2.43471353 |
| 11 | PIK3CG | 2.32087696 |
| 12 | ERBB3 | 2.05941483 |
| 13 | ERN1 | 2.03087688 |
| 14 | RPS6KB2 | 1.97427620 |
| 15 | NTRK1 | 1.95765749 |
| 16 | TRIB3 | 1.93568423 |
| 17 | EPHA3 | 1.93238636 |
| 18 | EPHA2 | 1.88751166 |
| 19 | FGFR2 | 1.86031002 |
| 20 | EPHB1 | 1.81330476 |
| 21 | OBSCN | 1.80674642 |
| 22 | CSNK1A1L | 1.76007103 |
| 23 | MAP3K2 | 1.72769026 |
| 24 | LRRK2 | 1.67318191 |
| 25 | CSNK1G3 | 1.62182848 |
| 26 | FGFR1 | 1.52969995 |
| 27 | MAP3K9 | 1.49554994 |
| 28 | BCR | 1.43521544 |
| 29 | MET | 1.43221056 |
| 30 | PTK6 | 1.41518689 |
| 31 | CDK12 | 1.39194240 |
| 32 | FGFR4 | 1.37093468 |
| 33 | MARK3 | 1.32802823 |
| 34 | ZAP70 | 1.27004971 |
| 35 | EEF2K | 1.26209875 |
| 36 | BRAF | 1.23816621 |
| 37 | CSNK1G1 | 1.21526684 |
| 38 | RPS6KA2 | 1.15158459 |
| 39 | FGFR3 | 1.09911833 |
| 40 | CSNK1G2 | 1.08180598 |
| 41 | RAF1 | 1.06760907 |
| 42 | PDGFRB | 1.05784958 |
| 43 | MAPKAPK5 | 0.99290886 |
| 44 | TGFBR2 | 0.98040493 |
| 45 | RPS6KB1 | 0.96969637 |
| 46 | MAP3K1 | 0.95080014 |
| 47 | MAP2K7 | 0.94982697 |
| 48 | MAP3K7 | 0.91592840 |
| 49 | SMG1 | 0.91187201 |
| 50 | GRK6 | 0.88538213 |
| 51 | ICK | 0.87424277 |
| 52 | TIE1 | 0.87029395 |
| 53 | TAOK1 | 0.83189406 |
| 54 | CDK6 | 0.83074245 |
| 55 | LATS2 | 0.82203447 |
| 56 | NME1 | 0.79550660 |
| 57 | NME2 | 0.79061454 |
| 58 | DDR2 | 0.79036841 |
| 59 | MAP2K3 | 0.78679824 |
| 60 | DMPK | 0.78248159 |
| 61 | PRKD1 | 0.77042787 |
| 62 | STK10 | 0.76670161 |
| 63 | PDK2 | 0.76451074 |
| 64 | PTK2 | 0.74680644 |
| 65 | SIK1 | 0.74231198 |
| 66 | MAPKAPK2 | 0.73115627 |
| 67 | TGFBR1 | 0.73073856 |
| 68 | PHKG1 | 0.72669030 |
| 69 | PHKG2 | 0.72669030 |
| 70 | MAP3K13 | 0.71391502 |
| 71 | MAP2K6 | 0.69618617 |
| 72 | DYRK1B | 0.66523912 |
| 73 | MAP2K1 | 0.66486370 |
| 74 | MAP3K10 | 0.66213722 |
| 75 | MTOR | 0.62461321 |
| 76 | SGK223 | 0.61954901 |
| 77 | SGK494 | 0.61954901 |
| 78 | TESK1 | 0.61562818 |
| 79 | RIPK1 | 0.61562199 |
| 80 | BLK | 0.59546802 |
| 81 | BMPR1B | 0.58311502 |
| 82 | RPS6KA4 | 0.57738112 |
| 83 | PDGFRA | 0.57318288 |
| 84 | PAK4 | 0.57001941 |
| 85 | GRK1 | 0.56372269 |
| 86 | STK38L | 0.54949516 |
| 87 | CDC42BPA | 0.54228131 |
| 88 | PAK3 | 0.54226442 |
| 89 | HIPK2 | 0.53547193 |
| 90 | DAPK2 | 0.53400313 |
| 91 | FLT3 | 0.50790058 |
| 92 | KSR2 | 0.49998853 |
| 93 | STK3 | 0.49641878 |
| 94 | PRPF4B | 0.49195629 |
| 95 | RPS6KL1 | 0.49166909 |
| 96 | RPS6KC1 | 0.49166909 |
| 97 | MAP2K2 | 0.49101528 |
| 98 | ITK | 0.47648419 |
| 99 | IKBKB | 0.47401384 |
| 100 | BMX | 0.47157105 |
| 101 | PBK | 0.44550330 |
| 102 | MAPK7 | 0.43309976 |
| 103 | LMTK2 | 0.43000457 |
| 104 | ROCK1 | 0.42586656 |
| 105 | CDK3 | 0.39858229 |
| 106 | NLK | 0.39798774 |
| 107 | STK38 | 0.39130948 |
| 108 | MAP3K8 | 0.38696561 |
| 109 | MAP3K6 | 0.38563330 |
| 110 | NEK2 | 0.38432482 |
| 111 | RPS6KA1 | 0.38191928 |
| 112 | PIM2 | 0.37349905 |
| 113 | PRKCQ | 0.37188184 |
| 114 | NEK6 | 0.37164050 |
| 115 | TYRO3 | 0.36216382 |
| 116 | ERBB2 | 0.36194390 |
| 117 | PRKD2 | 0.35025438 |
| 118 | CSF1R | 0.34485479 |
| 119 | IRAK3 | 0.33754771 |
| 120 | RPS6KA6 | 0.33741764 |
| 121 | GSK3A | 0.33678933 |
| 122 | CSNK1A1 | 0.33557376 |
| 123 | JAK2 | 0.33113832 |
| 124 | MAPK12 | 0.33001730 |
| 125 | RET | 0.32575119 |
| 126 | ILK | 0.32371778 |
| 127 | FGR | 0.31942942 |
| 128 | PIK3CA | 0.30550094 |
| 129 | MYLK | 0.30488989 |
| 130 | IRAK1 | 0.30387612 |
| 131 | MATK | 0.29698323 |
| 132 | PAK2 | 0.28779308 |
| 133 | PRKCE | 0.28046788 |
| 134 | TYK2 | 0.27521972 |
| 135 | NEK9 | 0.27156083 |
| 136 | STK24 | 0.27064889 |
| 137 | PRKCI | 0.26947389 |
| 138 | PKN2 | 0.26362111 |
| 139 | HCK | 0.26102399 |
| 140 | SRC | 0.25567866 |
| 141 | JAK1 | 0.25068606 |
| 142 | ROCK2 | 0.24774164 |
| 143 | NTRK2 | 0.23912651 |
| 144 | EPHA4 | 0.23386875 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Tyrosine metabolism_Homo sapiens_hsa00350 | 2.69015603 |
| 2 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.66873553 |
| 3 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.53942710 |
| 4 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.51232855 |
| 5 | Retinol metabolism_Homo sapiens_hsa00830 | 2.27455879 |
| 6 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.20031993 |
| 7 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.18235912 |
| 8 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.09475649 |
| 9 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.04768653 |
| 10 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.01811223 |
| 11 | Histidine metabolism_Homo sapiens_hsa00340 | 1.94284621 |
| 12 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.94087901 |
| 13 | Tight junction_Homo sapiens_hsa04530 | 1.81212580 |
| 14 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.80559469 |
| 15 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.79075473 |
| 16 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.79041490 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.68917869 |
| 18 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.66914024 |
| 19 | Adherens junction_Homo sapiens_hsa04520 | 1.61602849 |
| 20 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.60714831 |
| 21 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.47115529 |
| 22 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.46731512 |
| 23 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.46129186 |
| 24 | Amoebiasis_Homo sapiens_hsa05146 | 1.44495812 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.42722516 |
| 26 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.36649729 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.35657901 |
| 28 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.33898112 |
| 29 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.31053070 |
| 30 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.28286281 |
| 31 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.25113690 |
| 32 | Axon guidance_Homo sapiens_hsa04360 | 1.24916355 |
| 33 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.24658441 |
| 34 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 1.24145575 |
| 35 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.21308357 |
| 36 | Mineral absorption_Homo sapiens_hsa04978 | 1.19170459 |
| 37 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.18935937 |
| 38 | * Renin secretion_Homo sapiens_hsa04924 | 1.16729181 |
| 39 | Bladder cancer_Homo sapiens_hsa05219 | 1.11883428 |
| 40 | Focal adhesion_Homo sapiens_hsa04510 | 1.09288947 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.08907563 |
| 42 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.06968619 |
| 43 | * Salivary secretion_Homo sapiens_hsa04970 | 1.03992522 |
| 44 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.03795327 |
| 45 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.02922183 |
| 46 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.98461988 |
| 47 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.98372032 |
| 48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.97740974 |
| 49 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.96575284 |
| 50 | * Melanogenesis_Homo sapiens_hsa04916 | 0.95520947 |
| 51 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.95228073 |
| 52 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.93783670 |
| 53 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.92367488 |
| 54 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.92253826 |
| 55 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.91605145 |
| 56 | Prostate cancer_Homo sapiens_hsa05215 | 0.91025750 |
| 57 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.90574730 |
| 58 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.87820922 |
| 59 | * Glioma_Homo sapiens_hsa05214 | 0.87705437 |
| 60 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.86712527 |
| 61 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.84637968 |
| 62 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.80472831 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.78767211 |
| 64 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.77403816 |
| 65 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.77021046 |
| 66 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.76721315 |
| 67 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.76400867 |
| 68 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.75776043 |
| 69 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.75754499 |
| 70 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.75538132 |
| 71 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.75452565 |
| 72 | Ribosome_Homo sapiens_hsa03010 | 0.73927633 |
| 73 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.73707009 |
| 74 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.70925625 |
| 75 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.70894322 |
| 76 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.70733729 |
| 77 | * Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.70355567 |
| 78 | Thyroid cancer_Homo sapiens_hsa05216 | 0.69379915 |
| 79 | Insulin resistance_Homo sapiens_hsa04931 | 0.68800028 |
| 80 | * Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.68676581 |
| 81 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.67827468 |
| 82 | * Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.66806600 |
| 83 | Apoptosis_Homo sapiens_hsa04210 | 0.66500434 |
| 84 | * Gastric acid secretion_Homo sapiens_hsa04971 | 0.64521935 |
| 85 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.64482259 |
| 86 | * Olfactory transduction_Homo sapiens_hsa04740 | 0.64150184 |
| 87 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.63326597 |
| 88 | Platelet activation_Homo sapiens_hsa04611 | 0.62506587 |
| 89 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.61804075 |
| 90 | Hepatitis C_Homo sapiens_hsa05160 | 0.61413448 |
| 91 | Malaria_Homo sapiens_hsa05144 | 0.61317396 |
| 92 | ABC transporters_Homo sapiens_hsa02010 | 0.61250642 |
| 93 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.59374213 |
| 94 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.58249280 |
| 95 | * Ras signaling pathway_Homo sapiens_hsa04014 | 0.58142557 |
| 96 | Lysosome_Homo sapiens_hsa04142 | 0.57883542 |
| 97 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.57672350 |
| 98 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.56543097 |
| 99 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.56174173 |
| 100 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.56173737 |
| 101 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.55505127 |
| 102 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.54979684 |
| 103 | * Insulin signaling pathway_Homo sapiens_hsa04910 | 0.54901907 |
| 104 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.52803552 |
| 105 | Pathways in cancer_Homo sapiens_hsa05200 | 0.52042565 |
| 106 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.49623169 |
| 107 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.48977466 |
| 108 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.48971575 |
| 109 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.48714898 |
| 110 | * Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.48614227 |
| 111 | Endometrial cancer_Homo sapiens_hsa05213 | 0.47896625 |
| 112 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.47819139 |
| 113 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.47158231 |
| 114 | Bile secretion_Homo sapiens_hsa04976 | 0.46755621 |
| 115 | * Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.46742965 |
| 116 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.46334833 |
| 117 | Endocytosis_Homo sapiens_hsa04144 | 0.46021171 |
| 118 | * GnRH signaling pathway_Homo sapiens_hsa04912 | 0.45371724 |
| 119 | Prion diseases_Homo sapiens_hsa05020 | 0.44547949 |
| 120 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.44444998 |
| 121 | * Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.43939572 |
| 122 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.43624826 |
| 123 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.42936129 |
| 124 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.42393972 |
| 125 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.42314212 |
| 126 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.41405629 |
| 127 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.41113899 |
| 128 | Gap junction_Homo sapiens_hsa04540 | 0.40472179 |
| 129 | Circadian rhythm_Homo sapiens_hsa04710 | 0.40227539 |
| 130 | Phagosome_Homo sapiens_hsa04145 | 0.39620496 |
| 131 | * cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.38744582 |
| 132 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.38484496 |
| 133 | Long-term depression_Homo sapiens_hsa04730 | 0.36493408 |
| 134 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.34795525 |
| 135 | Salmonella infection_Homo sapiens_hsa05132 | 0.34675668 |
| 136 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.31727644 |
| 137 | Melanoma_Homo sapiens_hsa05218 | 0.30529314 |

