CALML4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.06127776
2drug transmembrane transport (GO:0006855)7.96466373
3drug transport (GO:0015893)7.11429048
4urate metabolic process (GO:0046415)7.09513400
5aminoglycoside antibiotic metabolic process (GO:0030647)6.90758053
6cilium or flagellum-dependent cell motility (GO:0001539)6.49577491
7drug catabolic process (GO:0042737)6.42635411
8phospholipid scrambling (GO:0017121)5.87674459
9organic cation transport (GO:0015695)5.82885234
10phosphate ion transport (GO:0006817)5.74488688
11exogenous drug catabolic process (GO:0042738)5.69107917
12flavonoid metabolic process (GO:0009812)5.52466871
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.51934962
14lysine metabolic process (GO:0006553)5.48482681
15lysine catabolic process (GO:0006554)5.48482681
16cilium movement (GO:0003341)5.47179510
17renal absorption (GO:0070293)5.22912561
18nonribosomal peptide biosynthetic process (GO:0019184)5.18009755
19phosphate ion transmembrane transport (GO:0035435)5.10085641
20modified amino acid transport (GO:0072337)5.08395335
21cysteine metabolic process (GO:0006534)5.07655646
22pyrimidine-containing compound transmembrane transport (GO:0072531)5.06761296
23uronic acid metabolic process (GO:0006063)4.90326486
24glucuronate metabolic process (GO:0019585)4.90326486
25intestinal absorption (GO:0050892)4.89762131
26epithelial cilium movement (GO:0003351)4.88186176
27motile cilium assembly (GO:0044458)4.86789970
28cellular glucuronidation (GO:0052695)4.84102006
29positive regulation of respiratory burst (GO:0060267)4.78149456
30regulation of guanylate cyclase activity (GO:0031282)4.73968557
31regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.71971940
32ethanol oxidation (GO:0006069)4.68524836
33glutathione biosynthetic process (GO:0006750)4.57009428
34excretion (GO:0007588)4.54462619
35quaternary ammonium group transport (GO:0015697)4.50950372
36ethanol metabolic process (GO:0006067)4.50843617
37glyoxylate metabolic process (GO:0046487)4.50175010
38epoxygenase P450 pathway (GO:0019373)4.47311345
39homocysteine metabolic process (GO:0050667)4.44867542
40primary alcohol catabolic process (GO:0034310)4.31693178
41calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.31044762
42sulfur compound transport (GO:0072348)4.22273424
43peptide catabolic process (GO:0043171)4.19950528
44short-chain fatty acid metabolic process (GO:0046459)4.19807786
45glutathione derivative biosynthetic process (GO:1901687)4.16350961
46glutathione derivative metabolic process (GO:1901685)4.16350961
47intestinal epithelial cell development (GO:0060576)4.16225306
48oligosaccharide catabolic process (GO:0009313)4.15513402
49mannose metabolic process (GO:0006013)4.13295828
50glutathione metabolic process (GO:0006749)4.11944737
51fructose metabolic process (GO:0006000)4.05744530
52regulation of cellular extravasation (GO:0002691)4.00541450
53fat-soluble vitamin biosynthetic process (GO:0042362)3.95381620
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.91071101
55purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.91071101
56proline metabolic process (GO:0006560)3.90222615
57response to mercury ion (GO:0046689)3.89100613
58phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.87854620
59cellular ketone body metabolic process (GO:0046950)3.85212380
60vitamin transport (GO:0051180)3.84259852
61peptide biosynthetic process (GO:0043043)3.80118208
62maintenance of gastrointestinal epithelium (GO:0030277)3.80086764
63sperm capacitation (GO:0048240)3.76952709
64trivalent inorganic anion homeostasis (GO:0072506)3.72751319
65phosphate ion homeostasis (GO:0055062)3.72751319
66negative regulation of neurotransmitter secretion (GO:0046929)3.69521961
67antibacterial humoral response (GO:0019731)3.69286329
68vitamin transmembrane transport (GO:0035461)3.69262610
69sulfur amino acid catabolic process (GO:0000098)3.67451329
70sulfate transmembrane transport (GO:1902358)3.65879023
71transcytosis (GO:0045056)3.63732262
72membrane repolarization during action potential (GO:0086011)3.63690869
73drug metabolic process (GO:0017144)3.63152471
74angiotensin maturation (GO:0002003)3.62296727
75O-glycan processing (GO:0016266)3.62201303
76polyol transport (GO:0015791)3.61993073
77antimicrobial humoral response (GO:0019730)3.60592640
78response to phenylpropanoid (GO:0080184)3.60235383
79transepithelial transport (GO:0070633)3.58504647
80lipoprotein transport (GO:0042953)3.58364234
81tricarboxylic acid metabolic process (GO:0072350)3.58273577
82regulation of bile acid biosynthetic process (GO:0070857)3.57540867
83bile acid and bile salt transport (GO:0015721)3.56627601
84amino-acid betaine metabolic process (GO:0006577)3.55928109
85carnitine metabolic process (GO:0009437)3.55109861
86cytidine deamination (GO:0009972)3.52418122
87cytidine metabolic process (GO:0046087)3.52418122
88cytidine catabolic process (GO:0006216)3.52418122
89regulation of respiratory burst (GO:0060263)3.52298917
90positive regulation of catecholamine secretion (GO:0033605)3.50479454
91aspartate family amino acid catabolic process (GO:0009068)3.50165583
92toxin transport (GO:1901998)3.50012661
93indole-containing compound catabolic process (GO:0042436)3.47816066
94indolalkylamine catabolic process (GO:0046218)3.47816066
95tryptophan catabolic process (GO:0006569)3.47816066
96vitamin D metabolic process (GO:0042359)3.47359732
97immunoglobulin mediated immune response (GO:0016064)3.46043863
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.45294978
99fatty acid beta-oxidation (GO:0006635)3.44362551
100axoneme assembly (GO:0035082)3.39396702
101carnitine transport (GO:0015879)3.38416451
102amino-acid betaine transport (GO:0015838)3.38416451
103bicarbonate transport (GO:0015701)3.35685287
104positive regulation of guanylate cyclase activity (GO:0031284)3.35019096
105ketone body metabolic process (GO:1902224)3.32876483
106fatty acid oxidation (GO:0019395)3.30402236
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26043214
108L-phenylalanine metabolic process (GO:0006558)3.26043214
109pyrimidine ribonucleoside catabolic process (GO:0046133)3.25294490
110NADH metabolic process (GO:0006734)3.25261236
111hormone catabolic process (GO:0042447)3.25199574
112aromatic amino acid family catabolic process (GO:0009074)3.24781268
113lipid oxidation (GO:0034440)3.24485760
114xenobiotic catabolic process (GO:0042178)3.23947980
115branched-chain amino acid metabolic process (GO:0009081)3.22660731
116glycoside metabolic process (GO:0016137)3.22379490
117tryptophan metabolic process (GO:0006568)3.22127118
118cellular modified amino acid catabolic process (GO:0042219)3.21487598
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20259717
120response to nitrosative stress (GO:0051409)3.17976146
121actin filament depolymerization (GO:0030042)3.17653268
122sulfate transport (GO:0008272)3.17226236
123regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.16638688
124endocrine process (GO:0050886)3.16638688
125regulation of systemic arterial blood pressure by hormone (GO:0001990)3.16638688
126serine family amino acid catabolic process (GO:0009071)3.12188855
127regulation of vitamin metabolic process (GO:0030656)3.10638212
128membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.08453380
129serine family amino acid metabolic process (GO:0009069)3.07278087
130hydrogen peroxide catabolic process (GO:0042744)3.07266551
131positive regulation of digestive system process (GO:0060456)3.06940126
132negative regulation of keratinocyte proliferation (GO:0010839)3.06929837
133bundle of His cell to Purkinje myocyte communication (GO:0086069)3.06927505
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06909571
135oligosaccharide biosynthetic process (GO:0009312)3.05223191
136antigen processing and presentation of endogenous antigen (GO:0019883)3.04185851
137benzene-containing compound metabolic process (GO:0042537)3.04110298
138urea cycle (GO:0000050)3.02568945
139neurotransmitter biosynthetic process (GO:0042136)3.02159749
140digestion (GO:0007586)3.01434383
141cellular response to vitamin D (GO:0071305)3.01207976
142phenylpropanoid metabolic process (GO:0009698)3.00854340
143intestinal cholesterol absorption (GO:0030299)3.00224244
144positive regulation of pseudopodium assembly (GO:0031274)2.99522805
145diterpenoid biosynthetic process (GO:0016102)2.96516044
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94977874
147receptor guanylyl cyclase signaling pathway (GO:0007168)2.93985761
148regulation of systemic arterial blood pressure (GO:0003073)2.91307628
149GDP-mannose metabolic process (GO:0019673)2.90874703
150negative regulation of protein tyrosine kinase activity (GO:0061099)2.90582983
151antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89966825
152urea metabolic process (GO:0019627)2.89796857
153primary alcohol metabolic process (GO:0034308)2.89376544
154positive regulation of amino acid transport (GO:0051957)2.89270416
155negative regulation of amino acid transport (GO:0051956)2.88920298
156glycosphingolipid catabolic process (GO:0046479)2.88676976
157negative regulation of T cell differentiation in thymus (GO:0033085)2.86556958
158glycolipid catabolic process (GO:0019377)2.82213950
159plasma lipoprotein particle assembly (GO:0034377)2.81827504
160regulation of cGMP biosynthetic process (GO:0030826)2.80966422
161sphingomyelin metabolic process (GO:0006684)2.80046683
162diacylglycerol metabolic process (GO:0046339)2.75364705
163left/right pattern formation (GO:0060972)2.72754677
164leukotriene metabolic process (GO:0006691)2.72368743
165very-low-density lipoprotein particle assembly (GO:0034379)2.71608890
166nucleotide transmembrane transport (GO:1901679)2.71558738
167regulation of triglyceride catabolic process (GO:0010896)2.70886549
168digestive system process (GO:0022600)2.70283498
169positive regulation of antigen processing and presentation (GO:0002579)2.68958808
170N-glycan processing (GO:0006491)2.68655016
171nitrogen cycle metabolic process (GO:0071941)2.66556049
172citrulline biosynthetic process (GO:0019240)2.64915887
173renal system process involved in regulation of blood volume (GO:0001977)2.62589601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.25442599
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.61670553
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.35959080
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.87598135
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.72738514
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70927589
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.70627275
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.66001513
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.57697152
10SOX2_27498859_Chip-Seq_STOMACH_Mouse3.17135234
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.05091025
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.97773098
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.93232739
14GATA4_25053715_ChIP-Seq_YYC3_Human2.87490848
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85809937
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.81203899
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.63358651
18* SOX2_20726797_ChIP-Seq_SW620_Human2.53713217
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.50452583
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43745179
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35186674
22GATA6_25053715_ChIP-Seq_YYC3_Human2.30275618
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22285831
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.19537063
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18498678
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11605410
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.98299316
28VDR_24763502_ChIP-Seq_THP-1_Human1.94684188
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88874937
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.85384475
31STAT1_20625510_ChIP-Seq_HELA_Human1.81197921
32* AR_21909140_ChIP-Seq_LNCAP_Human1.79183365
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75033720
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74447152
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73141077
36BCOR_27268052_Chip-Seq_Bcells_Human1.71368976
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69361427
38BCL6_27268052_Chip-Seq_Bcells_Human1.64895665
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62832653
40CLOCK_20551151_ChIP-Seq_293T_Human1.62309814
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58964327
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53547824
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52829171
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51005718
45E2F1_20622854_ChIP-Seq_HELA_Human1.43756497
46* NANOG_20526341_ChIP-Seq_ESCs_Human1.43688311
47VDR_22108803_ChIP-Seq_LS180_Human1.41353438
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40687904
49VDR_21846776_ChIP-Seq_THP-1_Human1.40555286
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.39288693
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37381455
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.37195022
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36517934
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35015822
55RACK7_27058665_Chip-Seq_MCF-7_Human1.34277868
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33268370
57GATA1_19941826_ChIP-Seq_K562_Human1.33108622
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31538235
59CEBPB_22108803_ChIP-Seq_LS180_Human1.30689795
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30002785
61SA1_27219007_Chip-Seq_Bcells_Human1.29572577
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28780311
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28202774
64PHF8_20622854_ChIP-Seq_HELA_Human1.27911102
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25570140
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.25401537
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25307105
68DROSHA_22980978_ChIP-Seq_HELA_Human1.24909954
69* SPI1_23547873_ChIP-Seq_NB4_Human1.21136830
70CTCF_20526341_ChIP-Seq_ESCs_Human1.20610612
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20542701
72P300_27268052_Chip-Seq_Bcells_Human1.19987040
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.18833995
74RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18112162
75P68_20966046_ChIP-Seq_HELA_Human1.17809603
76FOXA1_25552417_ChIP-Seq_VCAP_Human1.17647287
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16985122
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16887268
79KLF5_25053715_ChIP-Seq_YYC3_Human1.16008766
80NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15193296
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15100186
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14573860
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13060729
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12110041
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11884882
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10483035
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09709785
88GATA1_22025678_ChIP-Seq_K562_Human1.09441338
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09132899
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08475453
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08323849
92AR_20517297_ChIP-Seq_VCAP_Human1.07168895
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.06921983
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06680711
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05801694
96GATA3_24758297_ChIP-Seq_MCF-7_Human1.02473008
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02466006
98GATA2_19941826_ChIP-Seq_K562_Human1.01603136
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01487536
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01368641
101* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00496980
102* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00397908
103HNFA_21074721_ChIP-Seq_CACO-2_Human1.00069491
104TP63_22573176_ChIP-Seq_HFKS_Human0.99645576
105ATF3_27146783_Chip-Seq_COLON_Human0.99236561
106CDX2_22108803_ChIP-Seq_LS180_Human0.97618353
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.97310808
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97165219
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96490368
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96062019
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95891097
112P53_21459846_ChIP-Seq_SAOS-2_Human0.95754550
113CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95032699
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94776865
115RBPJ_21746931_ChIP-Seq_IB4_Human0.94670550
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94288906
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94229478
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94160279
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93922764
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93630575
121YY1_22570637_ChIP-Seq_MALME-3M_Human0.92186466
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92127181
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91925423
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91548096
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91071358
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90784056
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86964189
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86840163
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86646639
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.86088150
131TAF2_19829295_ChIP-Seq_ESCs_Human0.85622458
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83763786
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83661182
134GATA3_21878914_ChIP-Seq_MCF-7_Human0.81882281
135JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81779495
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81327936
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80256874
138CJUN_26792858_Chip-Seq_BT549_Human0.80057121
139MYC_19915707_ChIP-ChIP_AK7_Human0.79287745
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77973215
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77462386
142RXR_22108803_ChIP-Seq_LS180_Human0.75565683
143* LXR_22292898_ChIP-Seq_THP-1_Human0.75366647
144BCAT_22108803_ChIP-Seq_LS180_Human0.74359393
145EGR1_19032775_ChIP-ChIP_M12_Human0.74157989
146* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73819498
147GATA3_21867929_ChIP-Seq_CD8_Mouse0.73634391
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.73316629
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.72976957
150SMC1_22415368_ChIP-Seq_MEFs_Mouse0.72810230
151STAT1_17558387_ChIP-Seq_HELA_Human0.71443082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.05538014
2MP0005377_hearing/vestibular/ear_phenot4.44465474
3MP0003878_abnormal_ear_physiology4.44465474
4MP0004019_abnormal_vitamin_homeostasis4.39607726
5MP0002139_abnormal_hepatobiliary_system4.23104786
6MP0004043_abnormal_pH_regulation4.14073694
7MP0008875_abnormal_xenobiotic_pharmacok3.61882666
8MP0005332_abnormal_amino_acid3.41601203
9MP0010234_abnormal_vibrissa_follicle3.41185079
10MP0009643_abnormal_urine_homeostasis3.06535061
11MP0005085_abnormal_gallbladder_physiolo2.83104266
12MP0001666_abnormal_nutrient_absorption2.72080045
13MP0003252_abnormal_bile_duct2.70146556
14MP0001765_abnormal_ion_homeostasis2.70030621
15MP0002138_abnormal_hepatobiliary_system2.60531925
16MP0008004_abnormal_stomach_pH2.56520420
17MP0004264_abnormal_extraembryonic_tissu2.34477412
18MP0005636_abnormal_mineral_homeostasis2.31244493
19MP0002277_abnormal_respiratory_mucosa2.28814758
20MP0001756_abnormal_urination2.18454370
21MP0002136_abnormal_kidney_physiology2.08653059
22MP0002132_abnormal_respiratory_system2.05618329
23MP0005365_abnormal_bile_salt1.94008703
24MP0003300_gastrointestinal_ulcer1.80886548
25MP0000538_abnormal_urinary_bladder1.80326149
26MP0003283_abnormal_digestive_organ1.79070950
27MP0003303_peritoneal_inflammation1.78846443
28MP0004782_abnormal_surfactant_physiolog1.78241267
29MP0003718_maternal_effect1.74481184
30MP0001663_abnormal_digestive_system1.73141890
31MP0002396_abnormal_hematopoietic_system1.71651956
32MP0000462_abnormal_digestive_system1.68616099
33MP0002822_catalepsy1.65546915
34MP0009785_altered_susceptibility_to1.65441890
35MP0001873_stomach_inflammation1.63893379
36MP0001958_emphysema1.62766923
37MP0003806_abnormal_nucleotide_metabolis1.60679177
38MP0003195_calcinosis1.57776206
39MP0005058_abnormal_lysosome_morphology1.55361114
40MP0006082_CNS_inflammation1.54368575
41MP0005381_digestive/alimentary_phenotyp1.54301136
42MP0005409_darkened_coat_color1.53915418
43MP0001835_abnormal_antigen_presentation1.51785504
44MP0003656_abnormal_erythrocyte_physiolo1.51256829
45MP0005084_abnormal_gallbladder_morpholo1.50307355
46MP0003866_abnormal_defecation1.50226824
47MP0003186_abnormal_redox_activity1.49445668
48MP0005387_immune_system_phenotype1.48859205
49MP0001790_abnormal_immune_system1.48859205
50MP0005025_abnormal_response_to1.41428198
51MP0001664_abnormal_digestion1.36000510
52MP0001845_abnormal_inflammatory_respons1.33468426
53MP0003868_abnormal_feces_composition1.32507748
54MP0002876_abnormal_thyroid_physiology1.32000603
55MP0010155_abnormal_intestine_physiology1.29225186
56MP0000465_gastrointestinal_hemorrhage1.28679183
57MP0000490_abnormal_crypts_of1.27196396
58MP0002148_abnormal_hypersensitivity_rea1.24824643
59MP0003436_decreased_susceptibility_to1.23687572
60MP0008961_abnormal_basal_metabolism1.22736257
61MP0001485_abnormal_pinna_reflex1.21693867
62MP0001188_hyperpigmentation1.21313286
63MP0010329_abnormal_lipoprotein_level1.20385204
64MP0005319_abnormal_enzyme/_coenzyme1.18420426
65MP0001800_abnormal_humoral_immune1.15625383
66MP0003191_abnormal_cellular_cholesterol1.15419662
67MP0002796_impaired_skin_barrier1.15142412
68MP0003879_abnormal_hair_cell1.14791137
69MP0005167_abnormal_blood-brain_barrier1.11661200
70MP0001986_abnormal_taste_sensitivity1.10154343
71MP0000477_abnormal_intestine_morphology1.09866601
72MP0009379_abnormal_foot_pigmentation1.09063836
73MP0004147_increased_porphyrin_level1.05005192
74MP0001764_abnormal_homeostasis1.04726029
75MP0005584_abnormal_enzyme/coenzyme_acti1.02480612
76MP0002928_abnormal_bile_duct1.01545606
77MP0005671_abnormal_response_to1.00222250
78MP0002452_abnormal_antigen_presenting0.97987843
79MP0002653_abnormal_ependyma_morphology0.97271015
80MP0002419_abnormal_innate_immunity0.93826175
81MP0008789_abnormal_olfactory_epithelium0.92184455
82MP0005000_abnormal_immune_tolerance0.92025849
83MP0004885_abnormal_endolymph0.90279773
84MP0009840_abnormal_foam_cell0.89704475
85MP0008872_abnormal_physiological_respon0.89526275
86MP0000678_abnormal_parathyroid_gland0.88749533
87MP0006292_abnormal_olfactory_placode0.88009412
88MP0002089_abnormal_postnatal_growth/wei0.87332006
89MP0002723_abnormal_immune_serum0.87182939
90MP0005451_abnormal_body_composition0.86342533
91MP0002098_abnormal_vibrissa_morphology0.85156793
92MP0000537_abnormal_urethra_morphology0.84583613
93MP0000230_abnormal_systemic_arterial0.84172762
94MP0001819_abnormal_immune_cell0.83758526
95MP0003453_abnormal_keratinocyte_physiol0.83314180
96MP0002405_respiratory_system_inflammati0.82779101
97MP0009333_abnormal_splenocyte_physiolog0.81372223
98MP0005501_abnormal_skin_physiology0.80523391
99MP0010678_abnormal_skin_adnexa0.80344551
100MP0001849_ear_inflammation0.79505774
101MP0002420_abnormal_adaptive_immunity0.79490444
102MP0000685_abnormal_immune_system0.79223496
103MP0002118_abnormal_lipid_homeostasis0.78891918
104MP0005670_abnormal_white_adipose0.78454406
105MP0005666_abnormal_adipose_tissue0.76957969
106MP0003693_abnormal_embryo_hatching0.76617543
107MP0002896_abnormal_bone_mineralization0.75785613
108MP0009765_abnormal_xenobiotic_induced0.75380708
109MP0002135_abnormal_kidney_morphology0.72769799
110MP0000681_abnormal_thyroid_gland0.72523830
111MP0003724_increased_susceptibility_to0.71331622
112MP0003315_abnormal_perineum_morphology0.71281375
113MP0003941_abnormal_skin_development0.71280553
114MP0001533_abnormal_skeleton_physiology0.70818472
115MP0002249_abnormal_larynx_morphology0.69412878
116MP0009384_cardiac_valve_regurgitation0.69326362
117MP0002160_abnormal_reproductive_system0.66961500
118MP0006036_abnormal_mitochondrial_physio0.65622963
119MP0005174_abnormal_tail_pigmentation0.64741642
120MP0000613_abnormal_salivary_gland0.63028127
121MP0009764_decreased_sensitivity_to0.62014202
122MP0009642_abnormal_blood_homeostasis0.61836675
123MP0000470_abnormal_stomach_morphology0.60665103
124MP0003638_abnormal_response/metabolism_0.60492021
125MP0002168_other_aberrant_phenotype0.57635381
126MP0000762_abnormal_tongue_morphology0.57443737
127MP0005166_decreased_susceptibility_to0.55417419
128MP0000609_abnormal_liver_physiology0.54930277
129MP0001963_abnormal_hearing_physiology0.52215952
130MP0001216_abnormal_epidermal_layer0.51120216
131MP0009053_abnormal_anal_canal0.51086753
132MP0005165_increased_susceptibility_to0.51055354
133MP0005257_abnormal_intraocular_pressure0.50427993
134MP0005408_hypopigmentation0.50000115
135MP0004484_altered_response_of0.48887238
136MP0005395_other_phenotype0.48730889
137MP0003705_abnormal_hypodermis_morpholog0.48372089
138MP0010030_abnormal_orbit_morphology0.47750216
139MP0003938_abnormal_ear_development0.45882200
140MP0000026_abnormal_inner_ear0.44586878
141MP0008469_abnormal_protein_level0.42190762
142MP0010352_gastrointestinal_tract_polyps0.40364396
143MP0000163_abnormal_cartilage_morphology0.40344527
144MP0004272_abnormal_basement_membrane0.40065073
145MP0005376_homeostasis/metabolism_phenot0.39442897
146MP0005310_abnormal_salivary_gland0.39142240
147MP0003183_abnormal_peptide_metabolism0.38208252

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.24644377
2Absent/shortened dynein arms (HP:0200106)6.80704801
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.80704801
4Metabolic alkalosis (HP:0200114)6.62874496
5Abnormal respiratory motile cilium physiology (HP:0012261)6.58306446
6Abnormal respiratory epithelium morphology (HP:0012253)6.44229184
7Abnormal respiratory motile cilium morphology (HP:0005938)6.44229184
8Abnormal ciliary motility (HP:0012262)6.37658597
9Hyperactive renin-angiotensin system (HP:0000841)6.21091991
10Rhinitis (HP:0012384)5.89497718
11Abnormality of chloride homeostasis (HP:0011422)5.65631968
12Abnormality of glutamine family amino acid metabolism (HP:0010902)5.51402934
13Increased circulating renin level (HP:0000848)5.25475604
14Chronic bronchitis (HP:0004469)5.21540638
15Gout (HP:0001997)5.15396077
16Hypokalemic alkalosis (HP:0001949)5.06177258
17Proximal tubulopathy (HP:0000114)5.03073992
18Hypomagnesemia (HP:0002917)4.96453334
19Nasal polyposis (HP:0100582)4.88508670
20Hyperglycinuria (HP:0003108)4.74851856
21Bronchiectasis (HP:0002110)4.68089810
22Abnormality of renal excretion (HP:0011036)4.66911935
23Abnormal urine output (HP:0012590)4.65651476
24Polyuria (HP:0000103)4.65127620
25Increased purine levels (HP:0004368)4.60629687
26Hyperuricemia (HP:0002149)4.60629687
27Abnormality of the nasal mucosa (HP:0000433)4.60396565
28Abnormality of magnesium homeostasis (HP:0004921)4.55548660
29Abnormality of purine metabolism (HP:0004352)4.18878636
30Abnormality of renin-angiotensin system (HP:0000847)4.10993776
31Abnormality of urine glucose concentration (HP:0011016)4.05149802
32Glycosuria (HP:0003076)4.05149802
33Alkalosis (HP:0001948)4.03081779
34Malnutrition (HP:0004395)4.02957851
35Hyperaldosteronism (HP:0000859)3.86279217
36Ileus (HP:0002595)3.84112653
37Generalized aminoaciduria (HP:0002909)3.82458355
38Hydroxyprolinuria (HP:0003080)3.74021792
39Abnormality of proline metabolism (HP:0010907)3.74021792
40Abnormal drinking behavior (HP:0030082)3.68018566
41Polydipsia (HP:0001959)3.68018566
42Abnormality of serine family amino acid metabolism (HP:0010894)3.64679987
43Abnormality of glycine metabolism (HP:0010895)3.64679987
44Male infertility (HP:0003251)3.56343921
45Delayed epiphyseal ossification (HP:0002663)3.50362330
46Tetany (HP:0001281)3.43105163
47Renal salt wasting (HP:0000127)3.36044038
48Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35041873
49Chronic sinusitis (HP:0011109)3.34666675
50Hyperphosphaturia (HP:0003109)3.32164502
51Hypercalciuria (HP:0002150)3.29017569
52Bronchitis (HP:0012387)3.28133191
53Recurrent sinusitis (HP:0011108)3.18194672
54Renal tubular acidosis (HP:0001947)3.17794381
55Ketoacidosis (HP:0001993)3.14779217
56Infertility (HP:0000789)3.13642507
57Abnormal tarsal ossification (HP:0008369)3.07654248
58Abnormality of nucleobase metabolism (HP:0010932)3.03825449
59Hypokalemia (HP:0002900)3.02530806
60Abnormal urine phosphate concentration (HP:0012599)2.98577583
61Widely patent fontanelles and sutures (HP:0004492)2.96029898
62Dehydration (HP:0001944)2.93943353
63Systemic lupus erythematosus (HP:0002725)2.82303324
64Nephrolithiasis (HP:0000787)2.75229790
65Vacuolated lymphocytes (HP:0001922)2.70327183
66Chronic otitis media (HP:0000389)2.70054029
67Vascular calcification (HP:0004934)2.69283457
68Abnormality of fatty-acid metabolism (HP:0004359)2.67891643
69Fat malabsorption (HP:0002630)2.65297053
70Flat acetabular roof (HP:0003180)2.62146206
71Dicarboxylic aciduria (HP:0003215)2.61139003
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61139003
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60140725
74Ventricular fibrillation (HP:0001663)2.52330428
75Abnormality of carpal bone ossification (HP:0006257)2.50942939
76Ketosis (HP:0001946)2.49487560
77Recurrent otitis media (HP:0000403)2.46783189
78Hypophosphatemia (HP:0002148)2.45484462
79Abnormality of potassium homeostasis (HP:0011042)2.43892331
80Thin bony cortex (HP:0002753)2.41676197
81Nausea (HP:0002018)2.39494779
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39205387
83Cardiovascular calcification (HP:0011915)2.39081357
84Hypobetalipoproteinemia (HP:0003563)2.38382792
85Abnormality of renal resorption (HP:0011038)2.37974678
86Facial shape deformation (HP:0011334)2.37823738
87Potter facies (HP:0002009)2.37823738
88Hyperammonemia (HP:0001987)2.37011637
89Abnormality of the 1st metacarpal (HP:0010009)2.34268817
90Metabolic acidosis (HP:0001942)2.32248744
91Rickets (HP:0002748)2.31127160
92Eczematoid dermatitis (HP:0000976)2.28886802
93Neonatal short-limb short stature (HP:0008921)2.27126770
94Metaphyseal irregularity (HP:0003025)2.21983756
95Hyperglycinemia (HP:0002154)2.21077124
96Lethargy (HP:0001254)2.20804309
97Congenital sensorineural hearing impairment (HP:0008527)2.19716293
98Abnormality of vitamin B metabolism (HP:0004340)2.18632450
99Pancreatitis (HP:0001733)2.17242673
100Chronic diarrhea (HP:0002028)2.14678780
101Renal tubular dysfunction (HP:0000124)2.14678212
102Abnormality of the vitamin B12 metabolism (HP:0004341)2.14290083
103Acute encephalopathy (HP:0006846)2.13980668
104Vomiting (HP:0002013)2.12979548
105Right ventricular cardiomyopathy (HP:0011663)2.10643181
106Hemorrhage of the eye (HP:0011885)2.10635980
107Enlarged epiphyses (HP:0010580)2.06236317
108Short 1st metacarpal (HP:0010034)2.05699409
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.05699409
110Nephrocalcinosis (HP:0000121)2.05012195
111Abnormality of the costochondral junction (HP:0000919)2.04165933
112Abdominal distention (HP:0003270)2.03950994
113Confusion (HP:0001289)2.03351033
114Methylmalonic aciduria (HP:0012120)2.02518091
115Hyponatremia (HP:0002902)1.99808869
116Delayed CNS myelination (HP:0002188)1.97705353
117Lip pit (HP:0100267)1.96428773
118Acanthocytosis (HP:0001927)1.95766956
119Cupped ribs (HP:0000887)1.95489582
120Recurrent bronchitis (HP:0002837)1.95165572
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.95161158
122Megaloblastic anemia (HP:0001889)1.93962305
123Abnormal foot bone ossification (HP:0010675)1.93378239
124Abnormality of sodium homeostasis (HP:0010931)1.92109599
125Metaphyseal cupping (HP:0003021)1.91784349
126Decreased circulating renin level (HP:0003351)1.90971851
127Steatorrhea (HP:0002570)1.89689001
128Autoimmune thrombocytopenia (HP:0001973)1.88571957
129Recurrent gram-negative bacterial infections (HP:0005420)1.87535289
130Recurrent bacterial skin infections (HP:0005406)1.85850787
131Abnormal hand bone ossification (HP:0010660)1.85316916
132Adrenal overactivity (HP:0002717)1.83772956
133Abnormal ossification of hand bones (HP:0005921)1.83697783
134Wide cranial sutures (HP:0010537)1.83068742
135Recurrent abscess formation (HP:0002722)1.83056224
136Petechiae (HP:0000967)1.79916732
137Abnormal enzyme/coenzyme activity (HP:0012379)1.77336393
138Pustule (HP:0200039)1.76155139
139Glomerulonephritis (HP:0000099)1.75196843
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74514146
141Abnormal hemoglobin (HP:0011902)1.74309233
142Abnormality of vitamin metabolism (HP:0100508)1.74254684
143Abnormality of pyrimidine metabolism (HP:0004353)1.74220825
144Intrahepatic cholestasis (HP:0001406)1.73547716
145Villous atrophy (HP:0011473)1.73144919
146Abnormality of small intestinal villus morphology (HP:0011472)1.73144919
147Cerebral edema (HP:0002181)1.71193172
148Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71162112
149Abnormality of macrophages (HP:0004311)1.67583901
150Short phalanx of the thumb (HP:0009660)1.65916159
151Pigmentary retinal degeneration (HP:0001146)1.65830168
152Posterior subcapsular cataract (HP:0007787)1.64116783
153Gastrointestinal infarctions (HP:0005244)1.62140769
154Abnormal rod and cone electroretinograms (HP:0008323)1.59996129
155Recurrent pneumonia (HP:0006532)1.59078294
156Myositis (HP:0100614)1.58614750
157Abnormal biliary tract morphology (HP:0012440)1.56637543
158Cone-rod dystrophy (HP:0000548)1.51995742
159Macrocytic anemia (HP:0001972)1.51974546
160Complement deficiency (HP:0004431)1.51516566
161Obstructive lung disease (HP:0006536)1.51089321
162Chronic obstructive pulmonary disease (HP:0006510)1.51089321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.27244013
2WNK45.81889898
3WNK34.74397917
4OXSR14.52560832
5ACVR1B4.39608350
6PIK3CA3.94701738
7MST43.39367268
8FRK3.38504032
9EIF2AK33.24404932
10STK393.21630879
11LMTK23.21316462
12MAP2K22.64287161
13STK38L2.63530605
14NME12.48407008
15MAP3K22.39542637
16CDK192.33507235
17STK242.28844677
18RIPK42.19542722
19MET2.07213657
20RIPK11.78179335
21MAPK151.69794648
22BCKDK1.67568988
23PRKG21.64880821
24NUAK11.51415416
25GRK61.28136444
26EPHB21.26407974
27WNK11.21334278
28MAP4K11.19939451
29NEK11.15616028
30BLK1.15301293
31MAP3K101.14856508
32PDK21.12488054
33PDK41.10185470
34PDK31.10185470
35TYK21.07900298
36KIT1.07027118
37KSR21.06713063
38MAP3K131.04306931
39MAP2K11.04257585
40EPHA21.03500291
41MAP2K60.99416355
42MAP3K30.94883464
43IRAK40.91931861
44TLK10.91740398
45PBK0.88665615
46ZAP700.88162765
47MYLK0.87987239
48PTK60.87984171
49GRK10.87444938
50TESK10.85804023
51PTK20.84632332
52TBK10.81676034
53TNIK0.79317890
54TAOK30.78845969
55ABL20.75976656
56STK380.74796796
57LRRK20.74356766
58SGK4940.73264722
59SGK2230.73264722
60BRSK20.71413970
61PRKCI0.70960234
62IRAK10.69921164
63PAK40.68300208
64LYN0.68261021
65STK100.66989514
66NME20.66603747
67IKBKE0.66447213
68DDR20.65078403
69PDK10.64556986
70MAP3K70.63542482
71PRKCQ0.59910439
72MAP3K140.59677956
73IKBKB0.57146711
74EPHB10.56585151
75NEK60.55744824
76FER0.55487067
77ERBB20.52405568
78HIPK20.51916272
79SMG10.50699479
80GSK3A0.50106982
81IRAK30.48624567
82PRKD20.47519064
83MAP3K80.47134576
84MAP3K110.46899884
85TTK0.46770906
86CAMK2D0.46170129
87CHUK0.45005221
88PRKAA20.44928538
89MAPK110.44753762
90MATK0.43894354
91SYK0.43633405
92STK160.43211566
93ERN10.42220655
94DYRK1B0.40802659
95BTK0.40513192
96INSRR0.39753439
97ABL10.39211492
98FGFR40.39118252
99PIM10.35417710
100MAP3K10.35226139
101TEC0.35202227
102CSF1R0.34200080
103TIE10.33364488
104DMPK0.29884287
105PRKCA0.29392003
106TAOK10.28595083
107ILK0.28572609
108TESK20.27073626
109ERBB30.26216473
110ROCK10.24996882
111PTK2B0.24674474
112MAPKAPK20.24608677
113LATS10.24579575
114ERBB40.24560393
115TXK0.23723222
116IRAK20.22878762
117PAK30.22712417
118PDPK10.22569792
119ADRBK20.22406329
120ITK0.21604823
121CDC42BPA0.21231457
122SGK20.21070526
123PRKAA10.20731484
124AURKB0.20133121
125SGK30.19754055
126CSNK1A10.17996500
127TGFBR20.17869408
128RPS6KB20.17340500
129SRC0.16940937
130CDK90.16476046
131PIK3CG0.16286342
132SGK10.15193607
133PRKCD0.14220996
134AKT20.13967986
135PRKACG0.13519274
136CAMK2G0.11397190
137MAP3K120.10252033
138PRKCZ0.09456107
139CSK0.09324580
140LIMK10.08920644
141BMX0.08431434
142MAPKAPK30.08232849
143MAP2K30.07886439
144PRKACA0.06910650
145JAK20.06845044
146TRPM70.06527564

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.97971133
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.57487139
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.31911733
4Sulfur metabolism_Homo sapiens_hsa009203.25320891
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16585255
6Butanoate metabolism_Homo sapiens_hsa006502.99294304
7Mineral absorption_Homo sapiens_hsa049782.97685015
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.62451420
9Vitamin digestion and absorption_Homo sapiens_hsa049772.50256577
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32691157
11Glutathione metabolism_Homo sapiens_hsa004802.17625701
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14948271
13Asthma_Homo sapiens_hsa053102.14114368
14Bile secretion_Homo sapiens_hsa049762.12179103
15Propanoate metabolism_Homo sapiens_hsa006402.04004344
16Tryptophan metabolism_Homo sapiens_hsa003801.98012538
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90258103
18Starch and sucrose metabolism_Homo sapiens_hsa005001.88680874
19Fatty acid degradation_Homo sapiens_hsa000711.84710393
20Allograft rejection_Homo sapiens_hsa053301.83159126
21Protein digestion and absorption_Homo sapiens_hsa049741.82802585
22Fat digestion and absorption_Homo sapiens_hsa049751.82317267
23Pyruvate metabolism_Homo sapiens_hsa006201.79829933
24Peroxisome_Homo sapiens_hsa041461.75430479
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74623986
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71440654
27Staphylococcus aureus infection_Homo sapiens_hsa051501.65776319
28Renin-angiotensin system_Homo sapiens_hsa046141.65087774
29Histidine metabolism_Homo sapiens_hsa003401.55597522
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53100071
31Autoimmune thyroid disease_Homo sapiens_hsa053201.48097652
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46822479
33Oxidative phosphorylation_Homo sapiens_hsa001901.44968804
34beta-Alanine metabolism_Homo sapiens_hsa004101.44233038
35Graft-versus-host disease_Homo sapiens_hsa053321.43042016
36Type I diabetes mellitus_Homo sapiens_hsa049401.41373041
37Chemical carcinogenesis_Homo sapiens_hsa052041.40913570
38Fructose and mannose metabolism_Homo sapiens_hsa000511.39721006
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37907197
40Folate biosynthesis_Homo sapiens_hsa007901.37342497
41Arginine and proline metabolism_Homo sapiens_hsa003301.37023053
42Carbon metabolism_Homo sapiens_hsa012001.32319722
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27200754
44PPAR signaling pathway_Homo sapiens_hsa033201.25385018
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.23909581
46Other glycan degradation_Homo sapiens_hsa005111.16794501
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16496781
48Glycerolipid metabolism_Homo sapiens_hsa005611.13272546
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12404702
50Retinol metabolism_Homo sapiens_hsa008301.10476698
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.10156840
52Parkinsons disease_Homo sapiens_hsa050121.09484354
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.09465659
54Galactose metabolism_Homo sapiens_hsa000521.07565923
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05326569
56Fatty acid metabolism_Homo sapiens_hsa012121.02319263
57Leishmaniasis_Homo sapiens_hsa051400.99704145
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96922982
59Arachidonic acid metabolism_Homo sapiens_hsa005900.96451380
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96303359
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94518793
62Arginine biosynthesis_Homo sapiens_hsa002200.91279938
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86744060
64Nitrogen metabolism_Homo sapiens_hsa009100.84159585
65Pentose phosphate pathway_Homo sapiens_hsa000300.82645756
66Sulfur relay system_Homo sapiens_hsa041220.79435306
67Alzheimers disease_Homo sapiens_hsa050100.79037895
68Huntingtons disease_Homo sapiens_hsa050160.78444710
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76260314
70Antigen processing and presentation_Homo sapiens_hsa046120.75290912
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73606586
72Selenocompound metabolism_Homo sapiens_hsa004500.71787616
73Collecting duct acid secretion_Homo sapiens_hsa049660.71669616
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69545254
75Metabolic pathways_Homo sapiens_hsa011000.63674402
76Hematopoietic cell lineage_Homo sapiens_hsa046400.62561376
77Caffeine metabolism_Homo sapiens_hsa002320.61759323
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60562307
79Thyroid hormone synthesis_Homo sapiens_hsa049180.60320885
80Lysine degradation_Homo sapiens_hsa003100.57407166
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.55573740
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55049257
83Biosynthesis of amino acids_Homo sapiens_hsa012300.53659094
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53441785
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.53369328
86Sphingolipid metabolism_Homo sapiens_hsa006000.51672745
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51076688
88Tuberculosis_Homo sapiens_hsa051520.50426486
89Phenylalanine metabolism_Homo sapiens_hsa003600.49506423
90Tight junction_Homo sapiens_hsa045300.48196977
91Ether lipid metabolism_Homo sapiens_hsa005650.46560194
92Rheumatoid arthritis_Homo sapiens_hsa053230.45766198
93Gastric acid secretion_Homo sapiens_hsa049710.45468279
94Pertussis_Homo sapiens_hsa051330.44243403
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41899101
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41188867
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40289114
98ABC transporters_Homo sapiens_hsa020100.38770000
99Influenza A_Homo sapiens_hsa051640.36953824
100Cardiac muscle contraction_Homo sapiens_hsa042600.34401951
101Linoleic acid metabolism_Homo sapiens_hsa005910.33220643
102Complement and coagulation cascades_Homo sapiens_hsa046100.32559370
103African trypanosomiasis_Homo sapiens_hsa051430.30758939
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30588491
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.29977034
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29211801
107Fatty acid elongation_Homo sapiens_hsa000620.29180207
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27328640
109Pancreatic secretion_Homo sapiens_hsa049720.26061848
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.25243264
111Herpes simplex infection_Homo sapiens_hsa051680.25059084
112Hepatitis C_Homo sapiens_hsa051600.23552363
113Ovarian steroidogenesis_Homo sapiens_hsa049130.23220388
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22018022
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21674789
116Tyrosine metabolism_Homo sapiens_hsa003500.20873707
117Toxoplasmosis_Homo sapiens_hsa051450.20870359
118Osteoclast differentiation_Homo sapiens_hsa043800.17812024
119Phagosome_Homo sapiens_hsa041450.16279862
120Vibrio cholerae infection_Homo sapiens_hsa051100.16239606
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15871288
122Bladder cancer_Homo sapiens_hsa052190.15092799
123Insulin resistance_Homo sapiens_hsa049310.14955364
124Primary immunodeficiency_Homo sapiens_hsa053400.14055064
125Legionellosis_Homo sapiens_hsa051340.13289043
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.11261388
127Thyroid cancer_Homo sapiens_hsa052160.08611358
128Ribosome_Homo sapiens_hsa030100.05159652
129Lysosome_Homo sapiens_hsa041420.01767358
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.00460244

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