CALML5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)9.44534574
2keratinocyte proliferation (GO:0043616)8.70649385
3epidermal cell differentiation (GO:0009913)8.57174662
4peptide cross-linking (GO:0018149)8.39717576
5bundle of His cell to Purkinje myocyte communication (GO:0086069)7.64120331
6long-chain fatty acid biosynthetic process (GO:0042759)7.56729940
7* epidermis development (GO:0008544)7.21183644
8linoleic acid metabolic process (GO:0043651)6.62021188
9intermediate filament organization (GO:0045109)6.57147176
10lipoxygenase pathway (GO:0019372)6.01091167
11detection of bacterium (GO:0016045)5.65787981
12skin morphogenesis (GO:0043589)5.54592408
13phosphatidylserine acyl-chain remodeling (GO:0036150)5.52369168
14phosphatidylinositol acyl-chain remodeling (GO:0036149)5.36365378
15hemidesmosome assembly (GO:0031581)5.25596538
16detection of other organism (GO:0098543)5.13263078
17intermediate filament cytoskeleton organization (GO:0045104)4.86069345
18intermediate filament-based process (GO:0045103)4.69828663
19establishment of planar polarity (GO:0001736)4.66801080
20establishment of tissue polarity (GO:0007164)4.66801080
21keratinocyte development (GO:0003334)4.36807733
22phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.32192979
23epithelial cell differentiation involved in prostate gland development (GO:0060742)4.24351391
24ectoderm development (GO:0007398)4.18863820
25regulation of natural killer cell differentiation (GO:0032823)4.17201510
26polarized epithelial cell differentiation (GO:0030859)4.14042126
27negative regulation of interferon-gamma production (GO:0032689)4.03326369
28phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.01244114
29lateral sprouting from an epithelium (GO:0060601)3.98716612
30fatty acid elongation (GO:0030497)3.92265807
31surfactant homeostasis (GO:0043129)3.87911377
32hair follicle morphogenesis (GO:0031069)3.74157124
33phosphatidylcholine acyl-chain remodeling (GO:0036151)3.70543858
34phosphatidylserine metabolic process (GO:0006658)3.55512664
35* epithelium development (GO:0060429)3.51204199
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49225164
37regulation of keratinocyte differentiation (GO:0045616)3.49116641
38gap junction assembly (GO:0016264)3.46627053
39positive regulation of monocyte chemotaxis (GO:0090026)3.34960698
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.28991191
41ceramide biosynthetic process (GO:0046513)3.28745072
42chemical homeostasis within a tissue (GO:0048875)3.25142196
43negative regulation of keratinocyte proliferation (GO:0010839)3.21761311
44positive regulation of epidermal cell differentiation (GO:0045606)3.21072785
45phospholipid catabolic process (GO:0009395)3.09684027
46eyelid development in camera-type eye (GO:0061029)3.04933481
47keratinization (GO:0031424)20.9040694
48establishment of skin barrier (GO:0061436)20.7466718
49epithelial cell-cell adhesion (GO:0090136)2.97575595
50positive regulation of cholesterol efflux (GO:0010875)2.92200203
51regulation of keratinocyte proliferation (GO:0010837)2.90619269
52positive regulation of keratinocyte differentiation (GO:0045618)2.90355226
53alditol phosphate metabolic process (GO:0052646)2.89168297
54detection of external biotic stimulus (GO:0098581)2.88989907
55phospholipid efflux (GO:0033700)2.88568156
56skin development (GO:0043588)2.88049345
57ventricular cardiac muscle cell action potential (GO:0086005)2.87317500
58hair cycle process (GO:0022405)2.86897661
59molting cycle process (GO:0022404)2.86897661
60positive regulation of epidermis development (GO:0045684)2.79689844
61sequestering of metal ion (GO:0051238)2.76679144
62atrioventricular valve morphogenesis (GO:0003181)2.76263229
63positive regulation of T cell chemotaxis (GO:0010820)2.72612789
64regulation of T cell chemotaxis (GO:0010819)2.72612789
65melanin biosynthetic process (GO:0042438)2.66588689
66regulation of epidermal cell differentiation (GO:0045604)2.61411193
67regulation of epidermis development (GO:0045682)2.58513569
68regulation of monocyte chemotaxis (GO:0090025)2.51128760
69epithelial cell differentiation (GO:0030855)2.48780403
70detection of biotic stimulus (GO:0009595)2.47127702
71melanin metabolic process (GO:0006582)2.46431456
72mitotic G1 DNA damage checkpoint (GO:0031571)2.45602268
73positive regulation of cholesterol transport (GO:0032376)2.44459104
74positive regulation of sterol transport (GO:0032373)2.44459104
75cellular response to antibiotic (GO:0071236)2.43326661
76one-carbon compound transport (GO:0019755)2.38691108
77intestinal epithelial cell development (GO:0060576)2.38630252
78regulation of heart rate by cardiac conduction (GO:0086091)2.37420232
79unsaturated fatty acid biosynthetic process (GO:0006636)2.37075258
80negative regulation of cell fate specification (GO:0009996)2.33765407
81regulation of ruffle assembly (GO:1900027)2.33713957
82sphingolipid biosynthetic process (GO:0030148)2.33510863
83defense response to fungus (GO:0050832)2.33185383
84phosphatidylglycerol metabolic process (GO:0046471)2.30949451
85response to phenylpropanoid (GO:0080184)2.29839307
86cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.26695057
87retinol metabolic process (GO:0042572)2.26263874
88mitotic G1/S transition checkpoint (GO:0044819)2.26136622
89epithelial cell proliferation (GO:0050673)2.23009867
90cell communication involved in cardiac conduction (GO:0086065)2.22285037
91genitalia morphogenesis (GO:0035112)2.21424050
92G1 DNA damage checkpoint (GO:0044783)2.21221802
93prostanoid biosynthetic process (GO:0046457)2.20863848
94prostaglandin biosynthetic process (GO:0001516)2.20863848
95regulation of water loss via skin (GO:0033561)17.9230480
96desmosome organization (GO:0002934)14.1123188
97multicellular organismal water homeostasis (GO:0050891)11.4339609
98keratinocyte differentiation (GO:0030216)10.9327970
99hair cycle (GO:0042633)10.0565151
100molting cycle (GO:0042303)10.0565151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.40870158
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human4.05995801
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99295041
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.72672825
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69891275
6* ESR2_21235772_ChIP-Seq_MCF-7_Human2.17681604
7* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.13287623
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12324580
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09915840
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.03425188
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.03425188
12TP63_22573176_ChIP-Seq_HFKS_Human2.01940491
13TP63_17297297_ChIP-ChIP_HaCaT_Human13.0737214
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91990576
15* ESR1_21235772_ChIP-Seq_MCF-7_Human1.85382061
16ZNF263_19887448_ChIP-Seq_K562_Human1.85047349
17TP63_23658742_ChIP-Seq_EP156T_Human1.82948049
18* RACK7_27058665_Chip-Seq_MCF-7_Human1.75703331
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75544827
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.69400504
21* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64097207
22* RUNX1_27514584_Chip-Seq_MCF-7_Human1.63684859
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.62415721
24KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53772111
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47645508
26KLF5_25053715_ChIP-Seq_YYC3_Human1.46309510
27LXR_22292898_ChIP-Seq_THP-1_Human1.42989375
28CTCF_27219007_Chip-Seq_Bcells_Human1.40680491
29* RXR_22108803_ChIP-Seq_LS180_Human1.39603752
30BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.38290856
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36979211
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35477198
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33235124
34EGR1_19032775_ChIP-ChIP_M12_Human1.32683500
35* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.32606459
36* GATA3_24758297_ChIP-Seq_MCF-7_Human1.23081308
37* UBF1/2_26484160_Chip-Seq_HMECs_Human1.22759002
38BCOR_27268052_Chip-Seq_Bcells_Human1.19603874
39ATF3_27146783_Chip-Seq_COLON_Human1.19462308
40GATA6_21074721_ChIP-Seq_CACO-2_Human1.18190208
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17993582
42SMC4_20622854_ChIP-Seq_HELA_Human1.17622618
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14979565
44KDM2B_26808549_Chip-Seq_K562_Human1.11999063
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11807597
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11354703
47AHR_22903824_ChIP-Seq_MCF-7_Human1.10926682
48SOX2_20726797_ChIP-Seq_SW620_Human1.08905056
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08899233
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.05913342
51* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05785997
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04662575
53AR_21572438_ChIP-Seq_LNCaP_Human1.04034727
54CTCF_20526341_ChIP-Seq_ESCs_Human1.03280845
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.02963310
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02542781
57E2F1_20622854_ChIP-Seq_HELA_Human1.01513346
58P68_20966046_ChIP-Seq_HELA_Human1.01337101
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99032416
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98900404
61GATA6_25053715_ChIP-Seq_YYC3_Human0.96598860
62P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95963656
63ERG_21242973_ChIP-ChIP_JURKAT_Human0.90689246
64TCF4_18268006_ChIP-ChIP_LS174T_Human0.90270520
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87397178
66P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87309950
67TBX20_22080862_ChIP-Seq_HEART_Mouse0.86559375
68TBX20_22328084_ChIP-Seq_HEART_Mouse0.86559375
69* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86329328
70PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86083577
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85225061
72PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84844742
73GATA4_25053715_ChIP-Seq_YYC3_Human0.84194282
74CLOCK_20551151_ChIP-Seq_293T_Human0.83547991
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82913295
76KDM2B_26808549_Chip-Seq_DND41_Human0.81897646
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81795626
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81576857
79BCL6_27268052_Chip-Seq_Bcells_Human0.81535152
80CJUN_26792858_Chip-Seq_BT549_Human0.80516319
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80387574
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80362542
83ARNT_22903824_ChIP-Seq_MCF-7_Human0.78328216
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78309142
85* CREB1_26743006_Chip-Seq_LNCaP_Human0.77468540
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77170878
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75492278
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.74366355
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.74293041
90TCF7_22412390_ChIP-Seq_EML_Mouse0.74061314
91P53_21459846_ChIP-Seq_SAOS-2_Human0.74010805
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73974940
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73714640
94* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70807828
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.70391583
96SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70249263
97SMAD4_21741376_ChIP-Seq_ESCs_Human0.68962223
98TRIM28_21343339_ChIP-Seq_HEK293_Human0.68558688
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.66259133
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.66043078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.25777782
2MP0005275_abnormal_skin_tensile6.85920925
3MP0010234_abnormal_vibrissa_follicle5.51554281
4MP0005501_abnormal_skin_physiology5.17767159
5MP0000579_abnormal_nail_morphology4.36136180
6MP0009379_abnormal_foot_pigmentation3.72388894
7MP0004381_abnormal_hair_follicle3.30407488
8MP0003453_abnormal_keratinocyte_physiol3.19965569
9MP0001216_abnormal_epidermal_layer3.13551415
10MP0003941_abnormal_skin_development2.83102760
11MP0010771_integument_phenotype2.75098207
12MP0002060_abnormal_skin_morphology2.73369342
13MP0004947_skin_inflammation2.67910450
14MP0002098_abnormal_vibrissa_morphology2.56964695
15MP0003705_abnormal_hypodermis_morpholog2.52966136
16MP0010678_abnormal_skin_adnexa2.51732809
17MP0000566_synostosis2.51510648
18MP0000383_abnormal_hair_follicle2.39574151
19MP0000377_abnormal_hair_follicle2.38961273
20MP0001188_hyperpigmentation2.38056528
21MP0002095_abnormal_skin_pigmentation2.25218705
22MP0000647_abnormal_sebaceous_gland2.17047726
23MP0000015_abnormal_ear_pigmentation2.16467414
24MP0003878_abnormal_ear_physiology1.98702089
25MP0005377_hearing/vestibular/ear_phenot1.98702089
26MP0005409_darkened_coat_color1.88230779
27MP0003191_abnormal_cellular_cholesterol1.86320677
28MP0005174_abnormal_tail_pigmentation1.84362486
29MP0009931_abnormal_skin_appearance1.76622564
30MP0004885_abnormal_endolymph1.73152854
31MP0005171_absent_coat_pigmentation1.58223971
32MP0000467_abnormal_esophagus_morphology1.52733033
33MP0005075_abnormal_melanosome_morpholog1.45509709
34MP0000427_abnormal_hair_cycle1.43678674
35MP0000367_abnormal_coat/_hair1.42646428
36MP0004782_abnormal_surfactant_physiolog1.37090755
37MP0000569_abnormal_digit_pigmentation1.36092238
38MP0003011_delayed_dark_adaptation1.31764509
39MP0003566_abnormal_cell_adhesion1.26293063
40MP0001191_abnormal_skin_condition1.24584340
41MP0004264_abnormal_extraembryonic_tissu1.09338680
42MP0001243_abnormal_dermal_layer1.04034037
43MP0000372_irregular_coat_pigmentation1.01586138
44MP0000762_abnormal_tongue_morphology0.98546015
45MP0002177_abnormal_outer_ear0.94258300
46MP0010352_gastrointestinal_tract_polyps0.93014517
47MP0000465_gastrointestinal_hemorrhage0.92885398
48MP0001851_eye_inflammation0.87758916
49MP0009780_abnormal_chondrocyte_physiolo0.87585357
50MP0005257_abnormal_intraocular_pressure0.87240487
51MP0002877_abnormal_melanocyte_morpholog0.84178806
52MP0005408_hypopigmentation0.80359741
53MP0010030_abnormal_orbit_morphology0.79283805
54MP0001784_abnormal_fluid_regulation0.78682964
55MP0005023_abnormal_wound_healing0.72331178
56MP0001186_pigmentation_phenotype0.60377651
57MP0003136_yellow_coat_color0.56432432
58MP0003763_abnormal_thymus_physiology0.55564266
59MP0004185_abnormal_adipocyte_glucose0.53325729
60MP0009333_abnormal_splenocyte_physiolog0.52551625
61MP0000371_diluted_coat_color0.52546625
62MP0008438_abnormal_cutaneous_collagen0.52466013
63MP0005503_abnormal_tendon_morphology0.50426380
64MP0001340_abnormal_eyelid_morphology0.50098518
65MP0002009_preneoplasia0.49272406
66MP0005076_abnormal_cell_differentiation0.42737620
67MP0002282_abnormal_trachea_morphology0.42226124
68MP0002075_abnormal_coat/hair_pigmentati0.41939878
69MP0002111_abnormal_tail_morphology0.41252020
70MP0002254_reproductive_system_inflammat0.40617240
71MP0009053_abnormal_anal_canal0.40307778
72MP0000627_abnormal_mammary_gland0.39212819
73MP0002166_altered_tumor_susceptibility0.35452000
74MP0001984_abnormal_olfaction0.35154763
75MP0003638_abnormal_response/metabolism_0.32887816
76MP0002006_tumorigenesis0.32305753
77MP0001958_emphysema0.30442810
78MP0000685_abnormal_immune_system0.27882990
79MP0000858_altered_metastatic_potential0.26863130
80MP0008260_abnormal_autophagy0.26034016
81MP0006138_congestive_heart_failure0.22030623
82MP0005508_abnormal_skeleton_morphology0.21165371
83MP0001299_abnormal_eye_distance/0.20445636
84MP0003045_fibrosis0.19906374
85MP0005666_abnormal_adipose_tissue0.19102251
86MP0005388_respiratory_system_phenotype0.18565987
87MP0002133_abnormal_respiratory_system0.18565987
88MP0002234_abnormal_pharynx_morphology0.18418127
89MP0005647_abnormal_sex_gland0.18010716
90MP0002249_abnormal_larynx_morphology0.15504809
91MP0003755_abnormal_palate_morphology0.15278203
92MP0002089_abnormal_postnatal_growth/wei0.15151501
93MP0005248_abnormal_Harderian_gland0.15108887
94MP0003300_gastrointestinal_ulcer0.14693961
95MP0000432_abnormal_head_morphology0.13679740
96MP0003448_altered_tumor_morphology0.12907401
97MP0003279_aneurysm0.12401885
98MP0008004_abnormal_stomach_pH0.12226600
99MP0002697_abnormal_eye_size0.11924488
100MP0005375_adipose_tissue_phenotype0.11770221

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.36712382
2Increased IgE level (HP:0003212)8.51256787
3Palmoplantar hyperkeratosis (HP:0000972)7.92134741
4Palmar hyperkeratosis (HP:0010765)7.52139688
5Erythroderma (HP:0001019)7.41714470
6Hypotrichosis (HP:0001006)7.32143734
7Congenital ichthyosiform erythroderma (HP:0007431)7.25252374
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.65240685
9Plantar hyperkeratosis (HP:0007556)6.57920825
10Alopecia of scalp (HP:0002293)6.33672963
11Onycholysis (HP:0001806)6.23114449
12Abnormality of the axillary hair (HP:0100134)6.21765803
13Abnormality of secondary sexual hair (HP:0009888)6.21765803
14Erythema (HP:0010783)6.15039185
15Thick nail (HP:0001805)5.37305979
16Corneal erosion (HP:0200020)5.32021293
17Woolly hair (HP:0002224)5.21296668
18Conjunctival hamartoma (HP:0100780)5.02442991
19Parakeratosis (HP:0001036)4.82682675
20Right ventricular cardiomyopathy (HP:0011663)4.78886668
21Pili torti (HP:0003777)4.55823222
22Eczematoid dermatitis (HP:0000976)4.24206122
23Abnormal hair laboratory examination (HP:0003328)4.01757185
24Oral leukoplakia (HP:0002745)3.99269430
25Palmoplantar keratoderma (HP:0000982)3.98102938
26Sparse eyelashes (HP:0000653)3.88952808
27Nail dystrophy (HP:0008404)3.80336238
28Gangrene (HP:0100758)3.78263319
29Absent eyelashes (HP:0000561)3.71385309
30Hypohidrosis (HP:0000966)3.69241518
31Lip pit (HP:0100267)3.54596391
32Abnormality of the salivary glands (HP:0010286)3.54560646
33Ectropion (HP:0000656)3.54030237
34Hamartoma of the eye (HP:0010568)3.48093718
35Fragile nails (HP:0001808)3.38836891
36Abnormal blistering of the skin (HP:0008066)3.32397113
37Sparse scalp hair (HP:0002209)3.27917215
38Absent hair (HP:0002298)3.12545230
39Abnormality of hair growth rate (HP:0011363)2.86398615
40Slow-growing hair (HP:0002217)2.86398615
41Brittle hair (HP:0002299)2.64776156
42Blepharitis (HP:0000498)2.64320407
43Pruritus (HP:0000989)2.63324316
44Milia (HP:0001056)2.48765902
45Natal tooth (HP:0000695)2.43331159
46Follicular hyperkeratosis (HP:0007502)2.41810890
47Melanocytic nevus (HP:0000995)2.35693653
48Hypoplastic labia majora (HP:0000059)2.31852250
49Advanced eruption of teeth (HP:0006288)2.31018614
50Nasolacrimal duct obstruction (HP:0000579)2.22286576
51Acanthosis nigricans (HP:0000956)2.19694415
52Lack of skin elasticity (HP:0100679)2.15424317
53Furrowed tongue (HP:0000221)2.14704751
54Ridged nail (HP:0001807)2.14639369
55Selective tooth agenesis (HP:0001592)2.12018156
56Hypergammaglobulinemia (HP:0010702)2.10376257
57Abnormality of the labia majora (HP:0012881)2.10339349
58Conical tooth (HP:0000698)2.03189697
59Curly hair (HP:0002212)2.03183788
60Hamartoma (HP:0010566)1.99246080
61Xerostomia (HP:0000217)1.95099019
62Pustule (HP:0200039)1.92617204
63Split foot (HP:0001839)1.92114169
64Duplicated collecting system (HP:0000081)1.91282879
65Abnormality of permanent molar morphology (HP:0011071)1.87115899
66Abnormality of the dental root (HP:0006486)1.87115899
67Taurodontia (HP:0000679)1.87115899
68Septate vagina (HP:0001153)1.84194120
69Dehydration (HP:0001944)1.78767657
70Abnormality of molar (HP:0011077)1.78288259
71Abnormality of molar morphology (HP:0011070)1.78288259
72Fine hair (HP:0002213)1.77827788
73Ventricular tachycardia (HP:0004756)1.74601685
74Hyperhidrosis (HP:0000975)1.71788253
75Oligodontia (HP:0000677)1.70753794
76Depressed nasal tip (HP:0000437)1.70500783
77Abnormality of the lacrimal duct (HP:0011481)1.70145519
78Skin ulcer (HP:0200042)1.69376383
79Abnormality of the dental pulp (HP:0006479)1.66952423
80Neonatal death (HP:0003811)1.66587320
81Neonatal short-limb short stature (HP:0008921)1.64983098
82Recurrent corneal erosions (HP:0000495)1.64890681
83Anonychia (HP:0001798)1.63674533
84Aplasia involving bones of the extremities (HP:0009825)1.62659841
85Aplasia involving bones of the upper limbs (HP:0009823)1.62659841
86Aplasia of the phalanges of the hand (HP:0009802)1.62659841
87Multifactorial inheritance (HP:0001426)1.61460665
88Abnormality of the renal collecting system (HP:0004742)1.59669735
89Amniotic constriction ring (HP:0009775)1.59612463
90Abnormality of placental membranes (HP:0011409)1.59612463
91Dry skin (HP:0000958)1.59190080
92Laryngomalacia (HP:0001601)1.56268182
93Autoamputation (HP:0001218)1.55854074
94Blue irides (HP:0000635)1.55654368
95Seborrheic dermatitis (HP:0001051)1.50376692
96Urticaria (HP:0001025)1.46431587
97Coarse hair (HP:0002208)1.45051894
98Abnormality of the nasolacrimal system (HP:0000614)1.45049226
99Sepsis (HP:0100806)1.41807428
100Breast hypoplasia (HP:0003187)1.39376451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.71941766
2TGFBR14.67393264
3EPHA24.29455493
4MAPKAPK34.26944344
5EEF2K3.88904096
6FGFR13.71112865
7FER2.97520153
8MST1R2.76272569
9STK242.56241066
10RIPK12.52076947
11FGFR32.47235010
12TRIB32.26722716
13MAP3K22.12022440
14SIK12.04280821
15TRPM71.88071473
16RPS6KB21.83130186
17MAP3K31.75675418
18PIK3CG1.68438174
19MAP2K61.46567697
20MET1.42101818
21ERN11.36311373
22CDK121.26421563
23MARK21.25041637
24PRPF4B1.23478986
25SGK4941.19013499
26SGK2231.19013499
27MAPK71.13104306
28EPHA31.12614406
29TESK11.12486542
30IKBKB1.12341047
31MAP3K11.09509587
32GRK61.08916749
33FGFR41.08601268
34MAPKAPK51.07231986
35LATS11.05244868
36PKN20.97036572
37PTK20.96518478
38PBK0.95103968
39FGFR20.94951040
40MAPK120.92832998
41MAP3K70.92352368
42PRKD20.91200316
43SMG10.89838254
44ICK0.84964135
45MAPKAPK20.84552107
46MTOR0.84006936
47NME20.79713342
48MAPK150.78675431
49RPS6KB10.77417117
50SGK20.74235539
51TAOK10.68880151
52ERBB20.67465549
53PDGFRA0.67245648
54DDR20.64935578
55SGK30.62744597
56EPHB10.62511764
57PRKAA20.62125037
58IRAK10.57761144
59PTK60.56747445
60STK38L0.55146191
61LRRK20.54769767
62KIT0.54321734
63NEK60.53926957
64NLK0.52769151
65RPS6KA20.52291055
66RET0.52043885
67CDC42BPA0.51357852
68PDGFRB0.50768518
69DMPK0.50631872
70BLK0.49184895
71CHUK0.48028936
72GSK3A0.47125647
73IKBKE0.43781104
74TGFBR20.39987775
75PRKCI0.38925233
76EPHB20.38442602
77MINK10.37324200
78SGK10.36968928
79LMTK20.36425898
80ILK0.35837676
81HIPK20.35812793
82BMX0.35118590
83ABL20.33044127
84STK30.32301570
85TYRO30.31422995
86ADRBK10.29291200
87CDK70.28816897
88CDK60.27341124
89JAK30.26647150
90MAP2K40.26502975
91CDK30.26191682
92SIK30.24369029
93MAPK90.24024182
94WNK10.23638761
95MST40.23297518
96STK380.22975383
97PRKD10.22868149
98MAPK110.22860920
99MATK0.22832633
100JAK10.22282606

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.32456891
2Linoleic acid metabolism_Homo sapiens_hsa005914.63497615
3Ether lipid metabolism_Homo sapiens_hsa005653.30542055
4Arachidonic acid metabolism_Homo sapiens_hsa005903.11852500
5Sphingolipid metabolism_Homo sapiens_hsa006002.55776381
6VEGF signaling pathway_Homo sapiens_hsa043702.33447449
7Histidine metabolism_Homo sapiens_hsa003402.10236285
8* GnRH signaling pathway_Homo sapiens_hsa049122.01799671
9Ovarian steroidogenesis_Homo sapiens_hsa049131.94680285
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84061082
11Staphylococcus aureus infection_Homo sapiens_hsa051501.72344989
12Fatty acid elongation_Homo sapiens_hsa000621.64218656
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.63774757
14Long-term depression_Homo sapiens_hsa047301.63349002
15Choline metabolism in cancer_Homo sapiens_hsa052311.59026746
16ECM-receptor interaction_Homo sapiens_hsa045121.57909184
17Dorso-ventral axis formation_Homo sapiens_hsa043201.55992082
18* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.53422848
19Circadian rhythm_Homo sapiens_hsa047101.50739151
20Notch signaling pathway_Homo sapiens_hsa043301.48847863
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47753634
22Amoebiasis_Homo sapiens_hsa051461.38253480
23Acute myeloid leukemia_Homo sapiens_hsa052211.36454013
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29451627
25* Vascular smooth muscle contraction_Homo sapiens_hsa042701.26229174
26Serotonergic synapse_Homo sapiens_hsa047261.13390211
27Bladder cancer_Homo sapiens_hsa052191.09586948
28Phospholipase D signaling pathway_Homo sapiens_hsa040721.06672641
29Platelet activation_Homo sapiens_hsa046111.06584624
30ABC transporters_Homo sapiens_hsa020101.05996574
31Sphingolipid signaling pathway_Homo sapiens_hsa040711.02172183
32* Ras signaling pathway_Homo sapiens_hsa040141.00758042
33Thyroid cancer_Homo sapiens_hsa052160.99218954
34MicroRNAs in cancer_Homo sapiens_hsa052060.96601105
35Adherens junction_Homo sapiens_hsa045200.94711112
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93783049
37* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87002701
38Inositol phosphate metabolism_Homo sapiens_hsa005620.84906208
39Phenylalanine metabolism_Homo sapiens_hsa003600.80554422
40Tyrosine metabolism_Homo sapiens_hsa003500.77404445
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77098419
42Tight junction_Homo sapiens_hsa045300.76063147
43Protein digestion and absorption_Homo sapiens_hsa049740.73608655
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.71874088
45Axon guidance_Homo sapiens_hsa043600.71868888
46Hepatitis C_Homo sapiens_hsa051600.71630197
47Focal adhesion_Homo sapiens_hsa045100.69614310
48Small cell lung cancer_Homo sapiens_hsa052220.68364927
49* Melanogenesis_Homo sapiens_hsa049160.67438475
50ErbB signaling pathway_Homo sapiens_hsa040120.65066260
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64347311
52Proteoglycans in cancer_Homo sapiens_hsa052050.63961394
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63851401
54Retinol metabolism_Homo sapiens_hsa008300.62894329
55PPAR signaling pathway_Homo sapiens_hsa033200.60283098
56Vitamin digestion and absorption_Homo sapiens_hsa049770.59787479
57Toxoplasmosis_Homo sapiens_hsa051450.59366690
58Endocytosis_Homo sapiens_hsa041440.58401925
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.58074129
60Glutamatergic synapse_Homo sapiens_hsa047240.57867069
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57823132
62Fatty acid biosynthesis_Homo sapiens_hsa000610.57543029
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56459521
64* Oxytocin signaling pathway_Homo sapiens_hsa049210.56243948
65Pancreatic cancer_Homo sapiens_hsa052120.56063637
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.54790889
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54346863
68* Renin secretion_Homo sapiens_hsa049240.52852544
69p53 signaling pathway_Homo sapiens_hsa041150.52293061
70* Glioma_Homo sapiens_hsa052140.52279214
71MAPK signaling pathway_Homo sapiens_hsa040100.51694946
72Lysosome_Homo sapiens_hsa041420.51432738
73Endometrial cancer_Homo sapiens_hsa052130.50767415
74Pathways in cancer_Homo sapiens_hsa052000.50698949
75Fat digestion and absorption_Homo sapiens_hsa049750.47966251
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46396744
77beta-Alanine metabolism_Homo sapiens_hsa004100.46138559
78* Estrogen signaling pathway_Homo sapiens_hsa049150.46120542
79Non-small cell lung cancer_Homo sapiens_hsa052230.45474772
80Pancreatic secretion_Homo sapiens_hsa049720.44123000
81Basal cell carcinoma_Homo sapiens_hsa052170.43576906
82Renal cell carcinoma_Homo sapiens_hsa052110.43242578
83Hippo signaling pathway_Homo sapiens_hsa043900.43116978
84* Neurotrophin signaling pathway_Homo sapiens_hsa047220.42883598
85Glycerolipid metabolism_Homo sapiens_hsa005610.41979603
86Prolactin signaling pathway_Homo sapiens_hsa049170.40152744
87Lysine degradation_Homo sapiens_hsa003100.39310056
88Influenza A_Homo sapiens_hsa051640.37555837
89Chronic myeloid leukemia_Homo sapiens_hsa052200.37271580
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35930762
91* Rap1 signaling pathway_Homo sapiens_hsa040150.35249042
92mTOR signaling pathway_Homo sapiens_hsa041500.35018971
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.31291427
94* Insulin signaling pathway_Homo sapiens_hsa049100.31254549
95Arginine biosynthesis_Homo sapiens_hsa002200.31120312
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30921900
97Prostate cancer_Homo sapiens_hsa052150.30402834
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29396379
99TNF signaling pathway_Homo sapiens_hsa046680.28045316
100* Tuberculosis_Homo sapiens_hsa051520.24994391

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