ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	actin filament-based movement (GO:0030048)	8.57153743
2	striated muscle contraction (GO:0006941)	7.99179853
3	myofibril assembly (GO:0030239)	7.43282456
4	regulation of relaxation of muscle (GO:1901077)	7.35563727
5	sarcomere organization (GO:0045214)	7.28480821
6	skeletal muscle fiber development (GO:0048741)	6.98260575
7	response to muscle activity (GO:0014850)	6.97469807
8	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	6.93981308
9	creatine metabolic process (GO:0006600)	6.74664389
10	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	6.45643627
11	plasma membrane repair (GO:0001778)	6.37511944
12	response to inactivity (GO:0014854)	6.36288621
13	myotube cell development (GO:0014904)	6.25905673
14	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	6.05331120
15	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.03271638
16	muscle contraction (GO:0006936)	6.02266296
17	actomyosin structure organization (GO:0031032)	5.63965589
18	skeletal muscle adaptation (GO:0043501)	5.60620317
19	positive regulation of myotube differentiation (GO:0010831)	5.51760407
20	cardiac myofibril assembly (GO:0055003)	5.38232656
21	muscle system process (GO:0003012)	5.34788488
22	negative regulation of potassium ion transmembrane transport (GO:1901380)	5.29514422
23	cardiac muscle contraction (GO:0060048)	5.26318441
24	skeletal muscle tissue development (GO:0007519)	5.18799161
25	glycogen catabolic process (GO:0005980)	5.09236173
26	skeletal muscle tissue regeneration (GO:0043403)	4.96548713
27	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	4.90186033
28	muscle fiber development (GO:0048747)	4.78012211
29	glucan catabolic process (GO:0009251)	4.77676639
30	muscle cell fate commitment (GO:0042693)	4.72586028
31	regulation of cell communication by electrical coupling (GO:0010649)	4.72563327
32	glucan biosynthetic process (GO:0009250)	4.59443212
33	glycogen biosynthetic process (GO:0005978)	4.59443212
34	muscle cell cellular homeostasis (GO:0046716)	4.57972356
35	muscle organ development (GO:0007517)	4.57227984
36	striated muscle atrophy (GO:0014891)	4.54809669
37	muscle structure development (GO:0061061)	4.53042167
38	cellular polysaccharide catabolic process (GO:0044247)	4.46596389
39	striated muscle adaptation (GO:0014888)	4.36761454
40	NADH metabolic process (GO:0006734)	4.21357278
41	myoblast fusion (GO:0007520)	4.09864596
42	muscle organ morphogenesis (GO:0048644)	4.06235314
43	regulation of skeletal muscle cell differentiation (GO:2001014)	4.05489826
44	regulation of actin filament-based movement (GO:1903115)	4.03603467
45	polysaccharide catabolic process (GO:0000272)	4.00993932
46	muscle atrophy (GO:0014889)	4.00234069
47	cardiac muscle hypertrophy (GO:0003300)	4.00038122
48	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.96136722
49	striated muscle cell development (GO:0055002)	3.82115281
50	striated muscle hypertrophy (GO:0014897)	3.81054699
51	positive regulation of myoblast differentiation (GO:0045663)	3.80821325
52	regulation of striated muscle contraction (GO:0006942)	3.80095713
53	regulation of myoblast differentiation (GO:0045661)	3.77530670
54	syncytium formation by plasma membrane fusion (GO:0000768)	3.71788870
55	negative regulation of protein localization to cell surface (GO:2000009)	3.70968432
56	fructose metabolic process (GO:0006000)	3.65725001
57	regulation of calcium ion transmembrane transport (GO:1903169)	3.65593736
58	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.65593736
59	response to activity (GO:0014823)	3.62473155
60	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.61424851
61	glycogen metabolic process (GO:0005977)	3.61416173
62	myotube differentiation (GO:0014902)	3.59583314
63	striated muscle tissue development (GO:0014706)	3.57080995
64	cellular glucan metabolic process (GO:0006073)	3.53885987
65	glucan metabolic process (GO:0044042)	3.53885987
66	muscle adaptation (GO:0043500)	3.53116492
67	regulation of myotube differentiation (GO:0010830)	3.51634411
68	muscle tissue morphogenesis (GO:0060415)	3.51286306
69	muscle hypertrophy (GO:0014896)	3.49147458
70	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	3.46872850
71	gluconeogenesis (GO:0006094)	3.44107391
72	cardiac muscle cell development (GO:0055013)	3.40398680
73	skeletal muscle cell differentiation (GO:0035914)	3.39824442
74	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.39371790
75	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.39371790
76	muscle cell development (GO:0055001)	3.36879871
77	negative regulation of cell size (GO:0045792)	3.35957306
78	2-oxoglutarate metabolic process (GO:0006103)	3.35725293
79	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.26304705
80	regulation of skeletal muscle fiber development (GO:0048742)	3.23707441
81	cardiac cell development (GO:0055006)	3.19530480
82	regulation of muscle system process (GO:0090257)	3.16217136
83	muscle tissue development (GO:0060537)	3.15542617
84	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.15489502
85	cardiac muscle tissue morphogenesis (GO:0055008)	3.14105891
86	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.12182159
87	regulation of sarcomere organization (GO:0060297)	3.11890140
88	hexose biosynthetic process (GO:0019319)	3.07278394
89	carnitine shuttle (GO:0006853)	3.05907063
90	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.03033182
91	negative regulation of muscle contraction (GO:0045932)	3.01994536
92	adult heart development (GO:0007512)	2.99695999
93	regulation of muscle contraction (GO:0006937)	2.99571147
94	syncytium formation (GO:0006949)	2.99087175
95	actin-myosin filament sliding (GO:0033275)	13.9121306
96	muscle filament sliding (GO:0030049)	13.9121306
97	skeletal muscle contraction (GO:0003009)	12.3930207
98	sarcoplasmic reticulum calcium ion transport (GO:0070296)	11.6273240
99	actin-mediated cell contraction (GO:0070252)	11.4281462
100	regulation of skeletal muscle contraction (GO:0014819)	11.1558450

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.92353354
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.39259284
3	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.03038722
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.98245505
5	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.77513088
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.72277487
7	TBX20_22080862_ChIP-Seq_HEART_Mouse	2.66942462
8	TBX20_22328084_ChIP-Seq_HEART_Mouse	2.66942462
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.61039340
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.60019632
11	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.44365398
12	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	2.35629590
13	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.18832405
14	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.15287415
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.14071178
16	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.10915863
17	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.10216751
18	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.98645620
19	LXR_22292898_ChIP-Seq_THP-1_Human	1.97755586
20	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.97511585
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.90303582
22	* CTCF_27219007_Chip-Seq_Bcells_Human	1.89578390
23	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.87614414
24	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.85766263
25	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.72197061
26	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.67136476
27	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.63550020
28	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.63233696
29	DROSHA_22980978_ChIP-Seq_HELA_Human	1.61737853
30	* KDM2B_26808549_Chip-Seq_DND41_Human	1.60809986
31	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.59521399
32	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.58353039
33	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.56962976
34	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.53666853
35	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.52426632
36	TCF7_22412390_ChIP-Seq_EML_Mouse	1.50483905
37	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.50167241
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.47266752
39	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.44366101
40	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.42848161
41	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.41942952
42	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.41219449
43	RACK7_27058665_Chip-Seq_MCF-7_Human	1.40679247
44	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.37316502
45	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.37034381
46	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.36948542
47	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.36884803
48	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.32453656
49	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.32095213
50	* SA1_27219007_Chip-Seq_Bcells_Human	1.31748874
51	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.30578537
52	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.29646976
53	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.25264825
54	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.25242353
55	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.23517438
56	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.23208305
57	CTCF_21964334_Chip-Seq_Bcells_Human	1.22600160
58	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.21774327
59	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.19437104
60	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.15597797
61	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.15046076
62	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.12806893
63	P68_20966046_ChIP-Seq_HELA_Human	1.11214965
64	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.10511638
65	CLOCK_20551151_ChIP-Seq_293T_Human	1.10113350
66	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.10099753
67	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.08140420
68	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.07444710
69	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.07306212
70	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.07220635
71	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.05796406
72	SMC4_20622854_ChIP-Seq_HELA_Human	1.05347980
73	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.03149351
74	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02619309
75	* KDM2B_26808549_Chip-Seq_K562_Human	1.01119131
76	CREB1_26743006_Chip-Seq_LNCaP_Human	0.99811288
77	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99707158
78	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99707158
79	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.99527841
80	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98583954
81	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.97659048
82	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.97545971
83	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.96550726
84	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.95693955
85	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.95081572
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94982427
87	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.94680685
88	SPI1_20517297_ChIP-Seq_HL60_Human	0.92042435
89	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.91662183
90	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.91585877
91	* TP63_22573176_ChIP-Seq_HFKS_Human	0.88859589
92	STAT1_20625510_ChIP-Seq_HELA_Human	0.88796996
93	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.88259617
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.85570406
95	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.84719764
96	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.84604602
97	OCT4_19829295_ChIP-Seq_ESCs_Human	0.84268184
98	OCT4_20526341_ChIP-Seq_ESCs_Human	0.84254865
99	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.84238497
100	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.84206603

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	6.90802623
2	MP0000751_myopathy	6.48580566
3	MP0000749_muscle_degeneration	6.10095049
4	MP0003646_muscle_fatigue	5.68280025
5	MP0004036_abnormal_muscle_relaxation	4.17579663
6	MP0002106_abnormal_muscle_physiology	3.85457068
7	MP0000759_abnormal_skeletal_muscle	3.79257256
8	MP0000747_muscle_weakness	3.75487107
9	MP0004087_abnormal_muscle_fiber	3.65920921
10	MP0005369_muscle_phenotype	3.35960874
11	MP0005451_abnormal_body_composition	3.30632649
12	MP0000750_abnormal_muscle_regeneration	3.27191636
13	MP0002269_muscular_atrophy	3.11439762
14	MP0004084_abnormal_cardiac_muscle	2.92358327
15	MP0005620_abnormal_muscle_contractility	2.90866626
16	MP0004233_abnormal_muscle_weight	2.88817325
17	MP0002332_abnormal_exercise_endurance	2.74590280
18	MP0000733_abnormal_muscle_development	2.62703100
19	MP0005330_cardiomyopathy	2.61421619
20	MP0004130_abnormal_muscle_cell	2.50148128
21	MP0002108_abnormal_muscle_morphology	2.43766721
22	MP0000013_abnormal_adipose_tissue	2.02269608
23	MP0002972_abnormal_cardiac_muscle	1.97240029
24	MP0008438_abnormal_cutaneous_collagen	1.77896499
25	MP0004270_analgesia	1.69186416
26	MP0002837_dystrophic_cardiac_calcinosis	1.66554499
27	MP0010630_abnormal_cardiac_muscle	1.60938933
28	MP0004484_altered_response_of	1.59113478
29	MP0006036_abnormal_mitochondrial_physio	1.58600736
30	MP0004510_myositis	1.52520493
31	MP0004215_abnormal_myocardial_fiber	1.41280870
32	MP0003950_abnormal_plasma_membrane	1.31910312
33	MP0002127_abnormal_cardiovascular_syste	1.25123815
34	MP0006138_congestive_heart_failure	1.23192255
35	MP0005266_abnormal_metabolism	1.21936875
36	MP0005385_cardiovascular_system_phenoty	1.14812348
37	MP0001544_abnormal_cardiovascular_syste	1.14812348
38	MP0000003_abnormal_adipose_tissue	1.13587767
39	MP0002971_abnormal_brown_adipose	1.13298130
40	MP0005275_abnormal_skin_tensile	1.08298126
41	MP0005375_adipose_tissue_phenotype	0.98247125
42	MP0004185_abnormal_adipocyte_glucose	0.97180590
43	MP0003705_abnormal_hypodermis_morpholog	0.95105091
44	MP0002822_catalepsy	0.93354694
45	MP0001661_extended_life_span	0.91403949
46	MP0010030_abnormal_orbit_morphology	0.91358906
47	MP0003221_abnormal_cardiomyocyte_apopto	0.82145449
48	MP0005666_abnormal_adipose_tissue	0.81252832
49	MP0003137_abnormal_impulse_conducting	0.79414448
50	MP0002249_abnormal_larynx_morphology	0.73029031
51	MP0004134_abnormal_chest_morphology	0.72939286
52	MP0001299_abnormal_eye_distance/	0.69985029
53	MP0009780_abnormal_chondrocyte_physiolo	0.69546543
54	MP0005503_abnormal_tendon_morphology	0.69329081
55	MP0005670_abnormal_white_adipose	0.68352046
56	MP0003879_abnormal_hair_cell	0.68278827
57	MP0000266_abnormal_heart_morphology	0.65241238
58	MP0003045_fibrosis	0.61947304
59	MP0003279_aneurysm	0.58238851
60	MP0003828_pulmonary_edema	0.56782008
61	MP0009250_abnormal_appendicular_skeleto	0.54804752
62	MP0002114_abnormal_axial_skeleton	0.54160827
63	MP0004085_abnormal_heartbeat	0.53588094
64	MP0008775_abnormal_heart_ventricle	0.51186240
65	MP0002896_abnormal_bone_mineralization	0.49263753
66	MP0001346_abnormal_lacrimal_gland	0.48147887
67	MP0009672_abnormal_birth_weight	0.45015342
68	MP0000762_abnormal_tongue_morphology	0.44435274
69	MP0004272_abnormal_basement_membrane	0.43820946
70	MP0002128_abnormal_blood_circulation	0.42468651
71	MP0003948_abnormal_gas_homeostasis	0.41635192
72	MP0000534_abnormal_ureter_morphology	0.40025679
73	MP0009384_cardiac_valve_regurgitation	0.37713790
74	MP0005166_decreased_susceptibility_to	0.37265798
75	MP0000767_abnormal_smooth_muscle	0.35657985
76	MP0001958_emphysema	0.35649382
77	MP0002078_abnormal_glucose_homeostasis	0.35436258
78	MP0003656_abnormal_erythrocyte_physiolo	0.34925529
79	MP0000372_irregular_coat_pigmentation	0.34380230
80	MP0004858_abnormal_nervous_system	0.33743831
81	MP0001943_abnormal_respiration	0.33617251
82	MP0005595_abnormal_vascular_smooth	0.32911725
83	MP0005083_abnormal_biliary_tract	0.32116883
84	MP0008569_lethality_at_weaning	0.30587857
85	MP0001542_abnormal_bone_strength	0.28832515
86	MP0001849_ear_inflammation	0.28505907
87	MP0005535_abnormal_body_temperature	0.28223067
88	MP0005452_abnormal_adipose_tissue	0.28148360
89	MP0002734_abnormal_mechanical_nocicepti	0.28083580
90	MP0005319_abnormal_enzyme/_coenzyme	0.25118040
91	MP0003385_abnormal_body_wall	0.24750128
92	MP0005376_homeostasis/metabolism_phenot	0.24683454
93	MP0006276_abnormal_autonomic_nervous	0.24312047
94	MP0010368_abnormal_lymphatic_system	0.24125676
95	MP0004197_abnormal_fetal_growth/weight/	0.23777236
96	MP0005584_abnormal_enzyme/coenzyme_acti	0.22335594
97	MP0005334_abnormal_fat_pad	0.20685546
98	MP0005165_increased_susceptibility_to	0.19919066
99	MP0004142_abnormal_muscle_tone	0.19255898
100	MP0000230_abnormal_systemic_arterial	0.19165384

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber inclusion bodies (HP:0100299)	9.91705850
2	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	9.70232181
3	Distal arthrogryposis (HP:0005684)	9.23386069
4	Type 1 muscle fiber predominance (HP:0003803)	7.82787510
5	Exercise-induced myalgia (HP:0003738)	7.67752143
6	Round ear (HP:0100830)	7.26128507
7	Ulnar deviation of the wrist (HP:0003049)	6.92127343
8	Exercise-induced muscle cramps (HP:0003710)	6.60745077
9	Calcaneovalgus deformity (HP:0001848)	6.16514927
10	Muscle hypertrophy of the lower extremities (HP:0008968)	5.77830692
11	Myopathic facies (HP:0002058)	5.65484919
12	Deformed tarsal bones (HP:0008119)	5.48810415
13	Calf muscle hypertrophy (HP:0008981)	5.28525038
14	Absent phalangeal crease (HP:0006109)	5.03241855
15	EMG: myopathic abnormalities (HP:0003458)	4.72407182
16	Muscle fiber splitting (HP:0003555)	4.59868479
17	Abnormality of the calf musculature (HP:0001430)	4.29878538
18	Hyporeflexia of lower limbs (HP:0002600)	4.27043620
19	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.23304585
20	Malignant hyperthermia (HP:0002047)	4.22625922
21	Abnormal finger flexion creases (HP:0006143)	4.19982068
22	Abnormality of skeletal muscle fiber size (HP:0012084)	4.10971682
23	Neck muscle weakness (HP:0000467)	4.10507575
24	Rhabdomyolysis (HP:0003201)	3.98727200
25	Myoglobinuria (HP:0002913)	3.91478728
26	Increased connective tissue (HP:0009025)	3.85354569
27	Subaortic stenosis (HP:0001682)	3.85320211
28	Abnormality of the left ventricular outflow tract (HP:0011103)	3.85320211
29	Fetal akinesia sequence (HP:0001989)	3.82205474
30	Abnormality of the calcaneus (HP:0008364)	3.80911465
31	Difficulty running (HP:0009046)	3.66754575
32	Increased variability in muscle fiber diameter (HP:0003557)	3.51129902
33	Asymmetric septal hypertrophy (HP:0001670)	3.48171258
34	Rimmed vacuoles (HP:0003805)	3.39073495
35	Muscle stiffness (HP:0003552)	3.32463771
36	Myotonia (HP:0002486)	3.23758484
37	Distal lower limb muscle weakness (HP:0009053)	3.11399996
38	Sudden death (HP:0001699)	3.09670910
39	Metatarsus adductus (HP:0001840)	3.04164970
40	Hip contracture (HP:0003273)	2.93378468
41	Popliteal pterygium (HP:0009756)	2.86190119
42	Frequent falls (HP:0002359)	2.85672389
43	Breech presentation (HP:0001623)	2.76763716
44	Areflexia of lower limbs (HP:0002522)	2.74199797
45	Mildly elevated creatine phosphokinase (HP:0008180)	2.73697232
46	EMG: neuropathic changes (HP:0003445)	2.67508644
47	Gowers sign (HP:0003391)	2.65729684
48	Bulbar palsy (HP:0001283)	2.59550963
49	Generalized muscle weakness (HP:0003324)	2.59284877
50	Trismus (HP:0000211)	2.57885670
51	Slender build (HP:0001533)	2.52344012
52	Abnormality of the neuromuscular junction (HP:0003398)	2.47233447
53	Fatigable weakness (HP:0003473)	2.47233447
54	Weak cry (HP:0001612)	2.44970353
55	Scapular winging (HP:0003691)	2.36533316
56	Limb-girdle muscle atrophy (HP:0003797)	2.34771703
57	Spinal rigidity (HP:0003306)	2.32740019
58	Bundle branch block (HP:0011710)	2.32277447
59	Distal lower limb amyotrophy (HP:0008944)	2.32114186
60	Ulnar deviation of finger (HP:0009465)	2.10715733
61	Ventricular tachycardia (HP:0004756)	2.07379617
62	Hyperkalemia (HP:0002153)	2.05681513
63	Limited hip movement (HP:0008800)	2.03061212
64	Dilated cardiomyopathy (HP:0001644)	2.02650073
65	Abnormality of placental membranes (HP:0011409)	2.02267714
66	Amniotic constriction ring (HP:0009775)	2.02267714
67	Nemaline bodies (HP:0003798)	10.1168839
68	Difficulty climbing stairs (HP:0003551)	1.97824388
69	Aplasia of the musculature (HP:0100854)	1.92763366
70	Progressive muscle weakness (HP:0003323)	1.92317437
71	Waddling gait (HP:0002515)	1.87966847
72	Lipoatrophy (HP:0100578)	1.85549316
73	Muscular dystrophy (HP:0003560)	1.85059996
74	Long clavicles (HP:0000890)	1.80908421
75	Adducted thumb (HP:0001181)	1.78840388
76	Type 2 muscle fiber atrophy (HP:0003554)	1.77895744
77	Abnormality of the shoulder girdle musculature (HP:0001435)	1.76184415
78	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.73840097
79	Abnormality of the foot musculature (HP:0001436)	1.72629120
80	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.72503905
81	Proximal amyotrophy (HP:0007126)	1.71665954
82	Lower limb amyotrophy (HP:0007210)	1.71332016
83	Tarsal synostosis (HP:0008368)	1.69223071
84	Muscle fiber atrophy (HP:0100295)	1.67106422
85	Limb-girdle muscle weakness (HP:0003325)	1.65308610
86	Foot dorsiflexor weakness (HP:0009027)	1.64702361
87	Facial diplegia (HP:0001349)	1.63486894
88	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.58679068
89	Rocker bottom foot (HP:0001838)	1.56139832
90	Heart block (HP:0012722)	1.55000719
91	Nonprogressive disorder (HP:0003680)	1.54300916
92	Synostosis involving bones of the lower limbs (HP:0009138)	1.51447599
93	Synostosis involving bones of the feet (HP:0009140)	1.51447599
94	Abnormal atrioventricular conduction (HP:0005150)	1.51053193
95	Easy fatigability (HP:0003388)	1.50356133
96	Webbed neck (HP:0000465)	1.48193770
97	Neoplasm of the heart (HP:0100544)	1.47019645
98	Abnormality of the hip-girdle musculature (HP:0001445)	1.46652463
99	Abnormality of the musculature of the pelvis (HP:0001469)	1.46652463
100	Thin ribs (HP:0000883)	1.46486539

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TTN	5.69434566
2	PHKG2	5.47138095
3	PHKG1	5.47138095
4	PIK3CG	3.72018700
5	MAPK12	2.16994356
6	EEF2K	2.04418230
7	OBSCN	10.4050321
8	MUSK	1.90741178
9	TRIB3	1.88361146
10	MAP2K3	1.82402354
11	MAPKAPK3	1.82188405
12	MAP3K7	1.69232125
13	NME1	1.48824434
14	TRPM7	1.46276005
15	PINK1	1.20038512
16	MOS	1.18462161
17	CCNB1	1.11276356
18	RIPK1	1.02160039
19	MAP2K4	0.99379118
20	DMPK	0.98187564
21	SIK1	0.95210561
22	DYRK1B	0.93697515
23	MAP3K13	0.90816009
24	MAP2K6	0.89514759
25	LIMK1	0.89178901
26	CAMK2G	0.87699334
27	MAPK7	0.87022072
28	MAP3K10	0.81530345
29	DDR2	0.79464650
30	PRKAA2	0.74983490
31	ICK	0.73167920
32	MARK1	0.72156165
33	PRKAA1	0.65003449
34	AKT2	0.64178243
35	MAPK11	0.60794977
36	NEK9	0.57126970
37	KSR2	0.56528569
38	MAPK4	0.55694228
39	PIK3CA	0.53125978
40	LATS2	0.50969074
41	RPS6KB2	0.49746567
42	PRPF4B	0.49383941
43	MAP2K1	0.48527032
44	MAPK15	0.48210825
45	PRKG1	0.47865093
46	NEK1	0.46716903
47	MARK2	0.45868306
48	CAMK4	0.45857550
49	ERBB3	0.44514150
50	EPHB1	0.40334473
51	PDPK1	0.40142788
52	ROCK1	0.39944216
53	FGFR4	0.39550664
54	TBK1	0.38311550
55	TIE1	0.38228005
56	MTOR	0.37700174
57	MAP3K1	0.37646571
58	SGK3	0.36431470
59	CAMK2D	0.34825548
60	PDGFRA	0.34720661
61	CAMK2B	0.34635893
62	CAMK1	0.34513815
63	TAOK2	0.33970810
64	TNK2	0.33815802
65	ARAF	0.33231947
66	CAMK2A	0.31182174
67	RPS6KC1	0.31017899
68	RPS6KL1	0.31017899
69	RPS6KA2	0.30340772
70	PKN1	0.28773105
71	MAPK10	0.28060020
72	PDK2	0.25319988
73	RPS6KB1	0.24803076
74	PKN2	0.24252624
75	RPS6KA3	0.24140331
76	CDC42BPA	0.23722364
77	PRKACA	0.23619613
78	MAP3K6	0.23122706
79	PDK1	0.23082513
80	ERN1	0.22654624
81	RPS6KA1	0.22600192
82	RPS6KA6	0.22138703
83	SGK1	0.21706708
84	IRAK2	0.21065726
85	PRKD1	0.16652737
86	ZAP70	0.15856994
87	PRKD2	0.14972534
88	PRKACB	0.14783834
89	MAP3K11	0.14531066
90	LATS1	0.14473334
91	SGK2	0.12669167
92	CDK19	0.12574029
93	ILK	0.11483229
94	TESK1	0.11127673
95	RAF1	0.10978706
96	MAP3K3	0.10858513
97	BMX	0.10683804
98	MAPK8	0.09593879
99	PRKG2	0.09205779
100	MAP2K2	0.08340690

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	4.97574358
2	Dilated cardiomyopathy_Homo sapiens_hsa05414	4.53774759
3	Cardiac muscle contraction_Homo sapiens_hsa04260	4.05747951
4	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.90558539
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.15590319
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.97587232
7	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.74821255
8	Circadian rhythm_Homo sapiens_hsa04710	2.45807731
9	* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.33799604
10	* Glucagon signaling pathway_Homo sapiens_hsa04922	2.13012967
11	* Insulin signaling pathway_Homo sapiens_hsa04910	2.12811547
12	Pentose phosphate pathway_Homo sapiens_hsa00030	2.04866129
13	* Oxytocin signaling pathway_Homo sapiens_hsa04921	1.93863387
14	Carbon metabolism_Homo sapiens_hsa01200	1.90842676
15	Arginine and proline metabolism_Homo sapiens_hsa00330	1.81239344
16	* Calcium signaling pathway_Homo sapiens_hsa04020	1.75629943
17	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.73743452
18	Insulin resistance_Homo sapiens_hsa04931	1.68808347
19	Tight junction_Homo sapiens_hsa04530	1.55079321
20	Arginine biosynthesis_Homo sapiens_hsa00220	1.53289883
21	AMPK signaling pathway_Homo sapiens_hsa04152	1.49129443
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.47811956
23	Focal adhesion_Homo sapiens_hsa04510	1.47589499
24	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.46761128
25	* cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.45994405
26	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.29345354
27	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.28441939
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.20124105
29	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.18183499
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.12556647
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.10606035
32	ECM-receptor interaction_Homo sapiens_hsa04512	1.05819203
33	* Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.00811114
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.00788904
35	Viral myocarditis_Homo sapiens_hsa05416	0.99622505
36	Nitrogen metabolism_Homo sapiens_hsa00910	0.95472867
37	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.94857989
38	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.94105185
39	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.92552345
40	* Gastric acid secretion_Homo sapiens_hsa04971	0.89612578
41	Amoebiasis_Homo sapiens_hsa05146	0.88181093
42	Fatty acid degradation_Homo sapiens_hsa00071	0.87253658
43	Alzheimers disease_Homo sapiens_hsa05010	0.86131167
44	* GnRH signaling pathway_Homo sapiens_hsa04912	0.81832346
45	Parkinsons disease_Homo sapiens_hsa05012	0.79380319
46	Protein digestion and absorption_Homo sapiens_hsa04974	0.77572465
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76721827
48	Galactose metabolism_Homo sapiens_hsa00052	0.75823007
49	VEGF signaling pathway_Homo sapiens_hsa04370	0.70856093
50	FoxO signaling pathway_Homo sapiens_hsa04068	0.69826648
51	MAPK signaling pathway_Homo sapiens_hsa04010	0.69345077
52	Propanoate metabolism_Homo sapiens_hsa00640	0.67797890
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.66292622
54	Insulin secretion_Homo sapiens_hsa04911	0.63392450
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62396081
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.62125658
57	mTOR signaling pathway_Homo sapiens_hsa04150	0.61266515
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58377206
59	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.57964921
60	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.55724090
61	* Long-term potentiation_Homo sapiens_hsa04720	0.53904885
62	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.53487213
63	Platelet activation_Homo sapiens_hsa04611	0.53312914
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.52641549
65	Notch signaling pathway_Homo sapiens_hsa04330	0.51810546
66	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.51542887
67	* Renin secretion_Homo sapiens_hsa04924	0.49719157
68	Thyroid cancer_Homo sapiens_hsa05216	0.43867167
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.42212655
70	Long-term depression_Homo sapiens_hsa04730	0.41371981
71	Proteoglycans in cancer_Homo sapiens_hsa05205	0.41151998
72	* Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41126167
73	Cholinergic synapse_Homo sapiens_hsa04725	0.39880394
74	Adherens junction_Homo sapiens_hsa04520	0.39458420
75	Lysine degradation_Homo sapiens_hsa00310	0.39145172
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38899965
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.37929725
78	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.37122259
79	Non-small cell lung cancer_Homo sapiens_hsa05223	0.36715092
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36595230
81	Renal cell carcinoma_Homo sapiens_hsa05211	0.35230436
82	Renin-angiotensin system_Homo sapiens_hsa04614	0.34518055
83	Endometrial cancer_Homo sapiens_hsa05213	0.32635412
84	Bile secretion_Homo sapiens_hsa04976	0.32452720
85	Oxidative phosphorylation_Homo sapiens_hsa00190	0.30506444
86	Sulfur relay system_Homo sapiens_hsa04122	0.28274454
87	* Salivary secretion_Homo sapiens_hsa04970	0.26181436
88	* Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.25268685
89	* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.24260899
90	* Glioma_Homo sapiens_hsa05214	0.24177883
91	Acute myeloid leukemia_Homo sapiens_hsa05221	0.24114439
92	Pancreatic secretion_Homo sapiens_hsa04972	0.23293902
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22770075
94	* Melanogenesis_Homo sapiens_hsa04916	0.22507156
95	* cAMP signaling pathway_Homo sapiens_hsa04024	0.22363293
96	Bladder cancer_Homo sapiens_hsa05219	0.21993833
97	* Circadian entrainment_Homo sapiens_hsa04713	0.20490265
98	ErbB signaling pathway_Homo sapiens_hsa04012	0.19518731
99	Small cell lung cancer_Homo sapiens_hsa05222	0.19127768
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15424884

CALML6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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