CALR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.20379094
2sperm motility (GO:0030317)8.49145883
3response to pheromone (GO:0019236)8.00886403
4cell wall macromolecule metabolic process (GO:0044036)7.91894473
5cell wall macromolecule catabolic process (GO:0016998)7.91894473
6protein targeting to Golgi (GO:0000042)7.80562810
7establishment of protein localization to Golgi (GO:0072600)7.53362278
8multicellular organism reproduction (GO:0032504)7.33603442
9protein polyglutamylation (GO:0018095)7.30132156
10sperm-egg recognition (GO:0035036)7.29309691
11retrograde transport, vesicle recycling within Golgi (GO:0000301)7.27507028
12microtubule polymerization or depolymerization (GO:0031109)7.26875770
13centriole replication (GO:0007099)7.22019104
14acrosome reaction (GO:0007340)7.20019800
15rRNA methylation (GO:0031167)7.18337140
16plasma membrane fusion (GO:0045026)6.99943703
17binding of sperm to zona pellucida (GO:0007339)6.89392553
18epithelial cilium movement (GO:0003351)6.65897457
19acrosome assembly (GO:0001675)6.59724223
20cell-cell recognition (GO:0009988)6.41970703
21piRNA metabolic process (GO:0034587)6.23316904
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.19440516
23reproduction (GO:0000003)6.18454270
24centriole assembly (GO:0098534)6.13226937
25spermatid development (GO:0007286)6.07692544
26rRNA modification (GO:0000154)6.02038268
27axonemal dynein complex assembly (GO:0070286)6.01887198
28male meiosis (GO:0007140)5.86749197
29phosphatidylethanolamine metabolic process (GO:0046337)5.79048410
30regulation of centriole replication (GO:0046599)5.74875847
31sexual reproduction (GO:0019953)5.73325401
32protein localization to Golgi apparatus (GO:0034067)5.62898041
33cilium or flagellum-dependent cell motility (GO:0001539)5.57940029
34motile cilium assembly (GO:0044458)5.47596712
35synaptonemal complex organization (GO:0070193)5.30336995
36synaptonemal complex assembly (GO:0007130)5.28219103
37regulation of cilium movement (GO:0003352)5.26881945
38positive regulation of Rab GTPase activity (GO:0032851)5.15597573
39regulation of Rab GTPase activity (GO:0032313)5.15597573
40single fertilization (GO:0007338)5.11179181
41cilium movement (GO:0003341)5.09474341
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.95227551
43RNA destabilization (GO:0050779)4.81976805
44sperm capacitation (GO:0048240)4.80978718
45tricarboxylic acid cycle (GO:0006099)4.66000363
46regulation of transcription involved in cell fate commitment (GO:0060850)4.56288278
47male meiosis I (GO:0007141)4.43785975
48multicellular organismal movement (GO:0050879)4.43512812
49musculoskeletal movement (GO:0050881)4.43512812
50regulation of inclusion body assembly (GO:0090083)4.37198534
51fertilization (GO:0009566)4.29445369
52* spermatogenesis (GO:0007283)4.27618143
53* male gamete generation (GO:0048232)4.26408508
54nucleus organization (GO:0006997)4.16509125
55microtubule nucleation (GO:0007020)4.07257948
56* gamete generation (GO:0007276)4.05624935
57organic cation transport (GO:0015695)4.00013736
58chromatin silencing (GO:0006342)3.99369015
59monoubiquitinated protein deubiquitination (GO:0035520)3.95466267
60microtubule depolymerization (GO:0007019)3.91826182
61DNA methylation involved in gamete generation (GO:0043046)3.88593937
62ketone body metabolic process (GO:1902224)3.85827061
63meiotic nuclear division (GO:0007126)3.85515252
64glomerular visceral epithelial cell development (GO:0072015)3.80510728
65negative regulation of inclusion body assembly (GO:0090084)3.79222114
66carnitine transmembrane transport (GO:1902603)3.77779517
67meiosis I (GO:0007127)3.74453860
68amino-acid betaine transport (GO:0015838)3.71980013
69carnitine transport (GO:0015879)3.71980013
70glomerular epithelial cell development (GO:0072310)3.60666234
71meiotic cell cycle (GO:0051321)3.57886945
72chromosome organization involved in meiosis (GO:0070192)3.54587446
73coenzyme catabolic process (GO:0009109)3.53249096
74cellular process involved in reproduction in multicellular organism (GO:0022412)3.49728763
75germ cell development (GO:0007281)3.46390468
76nuclear pore complex assembly (GO:0051292)3.44766815
77sarcomere organization (GO:0045214)3.44578177
78carnitine shuttle (GO:0006853)3.38363591
79ubiquinone biosynthetic process (GO:0006744)3.37181219
80quinone biosynthetic process (GO:1901663)3.37181219
81glycerol ether metabolic process (GO:0006662)3.36946805
82regulation of meiosis I (GO:0060631)3.35574223
83cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34621261
84Golgi to endosome transport (GO:0006895)3.34134954
85chromosome condensation (GO:0030261)3.29878122
86negative regulation of Rho protein signal transduction (GO:0035024)3.29816025
87negative regulation of potassium ion transmembrane transport (GO:1901380)3.23942344
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.20635471
89* multicellular organismal reproductive process (GO:0048609)3.17883953
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.17369837
91histone H3-K9 demethylation (GO:0033169)3.15752823
92fatty acid beta-oxidation (GO:0006635)3.15631064
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15565668
94chaperone-mediated protein complex assembly (GO:0051131)3.15427572
95membrane protein intracellular domain proteolysis (GO:0031293)3.14296755
96cerebral cortex neuron differentiation (GO:0021895)3.13855001
97aspartate family amino acid catabolic process (GO:0009068)3.12919625
98ventricular cardiac muscle cell development (GO:0055015)3.12180024
99regulation of sequestering of triglyceride (GO:0010889)3.09068652
100spermatid nucleus differentiation (GO:0007289)3.08818769
101ether metabolic process (GO:0018904)3.03848401
102glycolytic process (GO:0006096)3.03834172
103cardiolipin metabolic process (GO:0032048)3.03412309
104calcium ion-dependent exocytosis (GO:0017156)3.01646943
105microtubule severing (GO:0051013)3.01084918
106DNA packaging (GO:0006323)2.99925557
107multicellular organismal development (GO:0007275)2.99281261
108ubiquinone metabolic process (GO:0006743)2.99205153
109protein depolymerization (GO:0051261)2.98065558
110centrosome duplication (GO:0051298)2.97482730
111response to acidic pH (GO:0010447)2.97205572
112intra-Golgi vesicle-mediated transport (GO:0006891)2.96880422
113DNA conformation change (GO:0071103)2.96562479
114fatty acid transmembrane transport (GO:1902001)2.96257123
115cellular response to pH (GO:0071467)2.95663038
116polyamine biosynthetic process (GO:0006596)2.93466786
117homeostasis of number of cells within a tissue (GO:0048873)2.93090290
118axoneme assembly (GO:0035082)2.91145728
119ethanol oxidation (GO:0006069)2.90064880
120histone exchange (GO:0043486)2.89523106
121nucleosome disassembly (GO:0006337)2.88549517
122protein-DNA complex disassembly (GO:0032986)2.88549517
123single strand break repair (GO:0000012)2.87195512
124attachment of spindle microtubules to kinetochore (GO:0008608)2.86718845
125regulation of interleukin-13 production (GO:0032656)2.86594514
126fatty acid catabolic process (GO:0009062)2.84923304
127mitochondrial fission (GO:0000266)2.84542950
128mitotic G1 DNA damage checkpoint (GO:0031571)2.82940778
129cardiac myofibril assembly (GO:0055003)2.82596622
130cardiac muscle cell development (GO:0055013)2.80893992
131regulation of acyl-CoA biosynthetic process (GO:0050812)2.80468564
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73379353
133regulation of spindle checkpoint (GO:0090231)2.70547452
134seminiferous tubule development (GO:0072520)2.70191519
135meiotic cell cycle process (GO:1903046)2.69984246
136lipid oxidation (GO:0034440)2.67871270
137quaternary ammonium group transport (GO:0015697)2.65364282
138response to misfolded protein (GO:0051788)2.64363533
139regulation of microtubule-based movement (GO:0060632)2.63642653
140mitotic metaphase plate congression (GO:0007080)2.63522506
141left/right pattern formation (GO:0060972)2.61877715
142lysine catabolic process (GO:0006554)2.61658188
143lysine metabolic process (GO:0006553)2.61658188
144fatty acid oxidation (GO:0019395)2.61394105
145cellular ketone body metabolic process (GO:0046950)2.59106661
1462-oxoglutarate metabolic process (GO:0006103)2.57174393
147cardiac cell development (GO:0055006)2.57127568
148cell recognition (GO:0008037)2.55884284
149short-chain fatty acid metabolic process (GO:0046459)2.55614442
150carnitine metabolic process (GO:0009437)2.55190925
151pyruvate metabolic process (GO:0006090)2.55089077
152protein localization to chromosome, centromeric region (GO:0071459)2.52969972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.87414711
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.17875241
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.46260028
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.38815707
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.20105469
6EZH2_22144423_ChIP-Seq_EOC_Human2.72524557
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.71887710
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71887710
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56530956
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43032734
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.43024424
12CBP_20019798_ChIP-Seq_JUKART_Human2.32045737
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.32045737
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30674023
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26264659
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25355677
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23115025
18* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21851048
19FUS_26573619_Chip-Seq_HEK293_Human2.18776078
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15780464
21KAP1_22055183_ChIP-Seq_ESCs_Mouse2.11698846
22AR_21909140_ChIP-Seq_LNCAP_Human2.06514029
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06441440
24* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.89617722
25ER_23166858_ChIP-Seq_MCF-7_Human1.87204731
26ERA_21632823_ChIP-Seq_H3396_Human1.86107774
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85683391
28RAC3_21632823_ChIP-Seq_H3396_Human1.84905529
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.82347871
30DROSHA_22980978_ChIP-Seq_HELA_Human1.81205669
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77593463
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.77503659
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75544001
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72717454
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.72618687
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.72152043
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.70403290
38AR_21572438_ChIP-Seq_LNCaP_Human1.67210322
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.66415350
40* MYC_19829295_ChIP-Seq_ESCs_Human1.66037946
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64875582
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.63005074
43STAT1_17558387_ChIP-Seq_HELA_Human1.59958556
44TAF2_19829295_ChIP-Seq_ESCs_Human1.59877087
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58388940
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57983973
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54411103
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.53180780
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.53180780
50OCT4_20526341_ChIP-Seq_ESCs_Human1.52354191
51P300_19829295_ChIP-Seq_ESCs_Human1.51369989
52AR_25329375_ChIP-Seq_VCAP_Human1.49333476
53BCL6_27268052_Chip-Seq_Bcells_Human1.48912758
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48842862
55* ERG_20517297_ChIP-Seq_VCAP_Human1.48599128
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.48140646
57CTCF_27219007_Chip-Seq_Bcells_Human1.47976628
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45159748
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.42519577
60SMC4_20622854_ChIP-Seq_HELA_Human1.42341801
61RBPJ_21746931_ChIP-Seq_IB4_Human1.42142374
62E2F1_20622854_ChIP-Seq_HELA_Human1.42122122
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.42010723
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.41558355
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.39808876
66VDR_22108803_ChIP-Seq_LS180_Human1.39714780
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39041145
68CTCF_20526341_ChIP-Seq_ESCs_Human1.38044824
69TAF15_26573619_Chip-Seq_HEK293_Human1.37845328
70ETV1_20927104_ChIP-Seq_GIST48_Human1.36586179
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36311568
72CEBPB_22108803_ChIP-Seq_LS180_Human1.36311326
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36264940
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.35657906
75GATA3_21867929_ChIP-Seq_CD8_Mouse1.35433068
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34668871
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32801016
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.31123163
79TP53_18474530_ChIP-ChIP_U2OS_Human1.30742980
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30364359
81* PHF8_20622854_ChIP-Seq_HELA_Human1.29783533
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29678464
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29333944
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29328566
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29180674
86FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28080970
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.26943979
88* BCOR_27268052_Chip-Seq_Bcells_Human1.26871393
89TP63_22573176_ChIP-Seq_HFKS_Human1.26725619
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25820926
91PHF8_20622853_ChIP-Seq_HELA_Human1.25147798
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24719748
93NANOG_20526341_ChIP-Seq_ESCs_Human1.24650289
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.24509852
95TBL1_22424771_ChIP-Seq_293T_Human1.23857772
96P53_21459846_ChIP-Seq_SAOS-2_Human1.23840289
97ZNF263_19887448_ChIP-Seq_K562_Human1.23724541
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.23718429
99* P68_20966046_ChIP-Seq_HELA_Human1.22743283
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.22672733
101FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22659215
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21996924
103SOX2_19829295_ChIP-Seq_ESCs_Human1.20886302
104NANOG_19829295_ChIP-Seq_ESCs_Human1.20886302
105P300_27268052_Chip-Seq_Bcells_Human1.20271988
106STAT3_23295773_ChIP-Seq_U87_Human1.19588634
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18364277
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16989559
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.16713363
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15805168
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15789085
112ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15718177
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.14669326
114* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14353384
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14124383
116GATA6_21074721_ChIP-Seq_CACO-2_Human1.13926023
117HOXB7_26014856_ChIP-Seq_BT474_Human1.13572165
118P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12699130
119SMAD4_21799915_ChIP-Seq_A2780_Human1.12257158
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12028375
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10991185
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10426313
123TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09127916
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08922606
125ESET_19884257_ChIP-Seq_ESCs_Mouse1.08830917
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.08602848
127* RUNX2_22187159_ChIP-Seq_PCA_Human1.08228997
128GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.07918678
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07337017
130RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07249190
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06471877
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06206082
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06110722
134RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05988755
135* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05920604
136* WDR5_24793694_ChIP-Seq_LNCAP_Human1.05095126
137SALL1_21062744_ChIP-ChIP_HESCs_Human1.04683534
138SMRT_27268052_Chip-Seq_Bcells_Human1.04636854
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04597424
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.03771036
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03750406
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03340412
143SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02412670
144GATA3_21867929_ChIP-Seq_TH1_Mouse1.01056822
145PRDM14_20953172_ChIP-Seq_ESCs_Human1.00666439
146E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00291689
147OCT1_27270436_Chip-Seq_PROSTATE_Human1.00233267
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99642178
149SPI1_26923725_Chip-Seq_HPCs_Mouse0.97312337
150RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97184668
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96921192
152LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96836371
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96284646
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95859221
155HTT_18923047_ChIP-ChIP_STHdh_Human0.95381890
156ZNF274_21170338_ChIP-Seq_K562_Hela0.95077353
157TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94789798
158CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94658257
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.94604131
160MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94451533
161* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93911752
162* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93439659
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92983418
164KDM2B_26808549_Chip-Seq_REH_Human0.92702157
165NFYB_21822215_ChIP-Seq_K562_Human0.91788307
166PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91334811
167LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.91233597
168GABP_17652178_ChIP-ChIP_JURKAT_Human0.90126349
169FLI1_21867929_ChIP-Seq_TH2_Mouse0.89190665
170CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89006012
171GF1_26923725_Chip-Seq_HPCs_Mouse0.88805280
172GATA3_26560356_Chip-Seq_TH1_Human0.88633951
173SOX2_21211035_ChIP-Seq_LN229_Human0.88540683
174* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88460343
175FLI1_21867929_ChIP-Seq_CD8_Mouse0.88356769
176SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88059386
177NFYA_21822215_ChIP-Seq_K562_Human0.85894360
178NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84332086
179CTCF_26484167_Chip-Seq_Bcells_Mouse0.84255052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.93194007
2MP0003646_muscle_fatigue6.80839974
3MP0003878_abnormal_ear_physiology5.58704193
4MP0005377_hearing/vestibular/ear_phenot5.58704193
5MP0002837_dystrophic_cardiac_calcinosis4.24311222
6MP0001348_abnormal_lacrimal_gland3.34096312
7MP0000751_myopathy3.29943410
8MP0001929_abnormal_gametogenesis3.27090727
9MP0003698_abnormal_male_reproductive3.08887365
10MP0004084_abnormal_cardiac_muscle3.05376702
11MP0004215_abnormal_myocardial_fiber2.88662298
12MP0004036_abnormal_muscle_relaxation2.77301385
13MP0003806_abnormal_nucleotide_metabolis2.66172791
14MP0005670_abnormal_white_adipose2.49807895
15MP0008877_abnormal_DNA_methylation2.34249612
16MP0002210_abnormal_sex_determination2.20262688
17MP0006036_abnormal_mitochondrial_physio2.06205520
18MP0000678_abnormal_parathyroid_gland2.05742614
19MP0000749_muscle_degeneration2.05308404
20MP0005330_cardiomyopathy2.03551918
21MP0001485_abnormal_pinna_reflex1.93574258
22MP0002161_abnormal_fertility/fecundity1.83833515
23MP0004087_abnormal_muscle_fiber1.81895680
24MP0001486_abnormal_startle_reflex1.77626081
25MP0004130_abnormal_muscle_cell1.76217016
26MP0001145_abnormal_male_reproductive1.73908769
27MP0000653_abnormal_sex_gland1.73854175
28MP0002972_abnormal_cardiac_muscle1.73394088
29MP0003879_abnormal_hair_cell1.72405611
30MP0002139_abnormal_hepatobiliary_system1.72341881
31MP0005423_abnormal_somatic_nervous1.70120598
32MP0005310_abnormal_salivary_gland1.67803158
33MP0005379_endocrine/exocrine_gland_phen1.66488055
34MP0000750_abnormal_muscle_regeneration1.65528255
35MP0002269_muscular_atrophy1.64261762
36MP0006138_congestive_heart_failure1.63872280
37MP0005666_abnormal_adipose_tissue1.60474454
38MP0002653_abnormal_ependyma_morphology1.59915461
39MP0008775_abnormal_heart_ventricle1.59635660
40MP0002132_abnormal_respiratory_system1.59450435
41MP0005385_cardiovascular_system_phenoty1.56103611
42MP0001544_abnormal_cardiovascular_syste1.56103611
43MP0002106_abnormal_muscle_physiology1.55971258
44MP0003718_maternal_effect1.55506208
45MP0005620_abnormal_muscle_contractility1.42638551
46MP0003137_abnormal_impulse_conducting1.40417064
47MP0002138_abnormal_hepatobiliary_system1.38388345
48MP0004145_abnormal_muscle_electrophysio1.37865045
49MP0002822_catalepsy1.36005082
50MP0010630_abnormal_cardiac_muscle1.35480431
51MP0004233_abnormal_muscle_weight1.35379720
52MP0005451_abnormal_body_composition1.32384419
53MP0003279_aneurysm1.31235824
54MP0009053_abnormal_anal_canal1.29807386
55MP0002234_abnormal_pharynx_morphology1.27617884
56MP0009840_abnormal_foam_cell1.26178710
57MP0002127_abnormal_cardiovascular_syste1.24649145
58MP0003221_abnormal_cardiomyocyte_apopto1.23999807
59MP0004742_abnormal_vestibular_system1.23635306
60MP0003136_yellow_coat_color1.21375455
61MP0001963_abnormal_hearing_physiology1.21012844
62MP0003656_abnormal_erythrocyte_physiolo1.20046358
63MP0005365_abnormal_bile_salt1.16848386
64MP0005647_abnormal_sex_gland1.14381503
65MP0002249_abnormal_larynx_morphology1.14229406
66MP0005369_muscle_phenotype1.13240255
67MP0000534_abnormal_ureter_morphology1.12564675
68MP0001968_abnormal_touch/_nociception1.12114004
69MP0004484_altered_response_of1.11628432
70MP0010094_abnormal_chromosome_stability1.11256738
71MP0009697_abnormal_copulation1.10933612
72MP0004859_abnormal_synaptic_plasticity1.08824667
73MP0000759_abnormal_skeletal_muscle1.08070137
74MP0005551_abnormal_eye_electrophysiolog1.07079849
75MP0002735_abnormal_chemical_nociception1.06063218
76MP0000026_abnormal_inner_ear1.05717371
77MP0006035_abnormal_mitochondrial_morpho1.05165908
78MP0005253_abnormal_eye_physiology1.02776880
79MP0003011_delayed_dark_adaptation1.02063770
80MP0004085_abnormal_heartbeat1.01288672
81MP0003693_abnormal_embryo_hatching1.00507419
82MP0000747_muscle_weakness1.00139455
83MP0003077_abnormal_cell_cycle0.99566726
84MP0005332_abnormal_amino_acid0.99279091
85MP0005360_urolithiasis0.98680062
86MP0005085_abnormal_gallbladder_physiolo0.98450501
87MP0009384_cardiac_valve_regurgitation0.96138688
88MP0003186_abnormal_redox_activity0.94834884
89MP0000343_altered_response_to0.90598637
90MP0001529_abnormal_vocalization0.90325535
91MP0010368_abnormal_lymphatic_system0.89198894
92MP0002971_abnormal_brown_adipose0.86626262
93MP0002229_neurodegeneration0.86334992
94MP0004185_abnormal_adipocyte_glucose0.85341997
95MP0003950_abnormal_plasma_membrane0.85131884
96MP0005266_abnormal_metabolism0.84540439
97MP0003111_abnormal_nucleus_morphology0.84320439
98MP0001984_abnormal_olfaction0.84176621
99MP0000955_abnormal_spinal_cord0.83557939
100MP0005248_abnormal_Harderian_gland0.82983698
101MP0003699_abnormal_female_reproductive0.80325475
102MP0003329_amyloid_beta_deposits0.79798190
103MP0004510_myositis0.77223985
104MP0008569_lethality_at_weaning0.77057217
105MP0002282_abnormal_trachea_morphology0.76986844
106MP0005319_abnormal_enzyme/_coenzyme0.76791880
107MP0000358_abnormal_cell_content/0.76649551
108MP0002638_abnormal_pupillary_reflex0.76045858
109MP0010329_abnormal_lipoprotein_level0.75554421
110MP0001853_heart_inflammation0.75104838
111MP0008007_abnormal_cellular_replicative0.74114808
112MP0002118_abnormal_lipid_homeostasis0.73659841
113MP0001119_abnormal_female_reproductive0.72134558
114MP0002067_abnormal_sensory_capabilities0.70409006
115MP0005367_renal/urinary_system_phenotyp0.69877756
116MP0000516_abnormal_urinary_system0.69877756
117MP0002332_abnormal_exercise_endurance0.68359574
118MP0009115_abnormal_fat_cell0.67755306
119MP0002557_abnormal_social/conspecific_i0.65642881
120MP0005375_adipose_tissue_phenotype0.65185983
121MP0001270_distended_abdomen0.64902497
122MP0002733_abnormal_thermal_nociception0.63893709
123MP0001905_abnormal_dopamine_level0.63396269
124MP0005171_absent_coat_pigmentation0.63046252
125MP0005408_hypopigmentation0.62510480
126MP0001666_abnormal_nutrient_absorption0.62005025
127MP0004957_abnormal_blastocyst_morpholog0.61414131
128MP0002572_abnormal_emotion/affect_behav0.61242602
129MP0001764_abnormal_homeostasis0.61056526
130MP0009250_abnormal_appendicular_skeleto0.60336565
131MP0008058_abnormal_DNA_repair0.60317092
132MP0000266_abnormal_heart_morphology0.59835585
133MP0002163_abnormal_gland_morphology0.59699926
134MP0008995_early_reproductive_senescence0.59498453
135MP0001765_abnormal_ion_homeostasis0.59404374
136MP0002160_abnormal_reproductive_system0.58732348
137MP0000049_abnormal_middle_ear0.57686898
138MP0005636_abnormal_mineral_homeostasis0.56211701
139MP0000609_abnormal_liver_physiology0.55950687
140MP0002272_abnormal_nervous_system0.55414795
141MP0005395_other_phenotype0.55189934
142MP0005167_abnormal_blood-brain_barrier0.53579810
143MP0004043_abnormal_pH_regulation0.53427589
144MP0008875_abnormal_xenobiotic_pharmacok0.52717761
145MP0009745_abnormal_behavioral_response0.51503592
146MP0001440_abnormal_grooming_behavior0.50665784
147MP0005391_vision/eye_phenotype0.49627440
148MP0001970_abnormal_pain_threshold0.48771586
149MP0005535_abnormal_body_temperature0.46235585
150MP0002734_abnormal_mechanical_nocicepti0.46148354
151MP0000681_abnormal_thyroid_gland0.44258174
152MP0005083_abnormal_biliary_tract0.43823655
153MP0002168_other_aberrant_phenotype0.42982802
154MP0003119_abnormal_digestive_system0.42195265
155MP0001501_abnormal_sleep_pattern0.40642664
156MP0002928_abnormal_bile_duct0.39946100
157MP0002736_abnormal_nociception_after0.38101414
158MP0002254_reproductive_system_inflammat0.37939158
159MP0000230_abnormal_systemic_arterial0.37778979
160MP0006292_abnormal_olfactory_placode0.37410575
161MP0003045_fibrosis0.37065203
162MP0001545_abnormal_hematopoietic_system0.36011648
163MP0005397_hematopoietic_system_phenotyp0.36011648
164MP0003880_abnormal_central_pattern0.35972993

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.73374244
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.51343016
3Absent/shortened dynein arms (HP:0200106)6.99070108
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.99070108
5Tubulointerstitial nephritis (HP:0001970)6.03271886
6Chronic hepatic failure (HP:0100626)5.72797595
7Male infertility (HP:0003251)4.89353217
8Abnormal respiratory motile cilium physiology (HP:0012261)4.87924389
9Bony spicule pigmentary retinopathy (HP:0007737)4.70594077
10Attenuation of retinal blood vessels (HP:0007843)4.70227123
11Abnormal respiratory motile cilium morphology (HP:0005938)4.66074961
12Abnormal respiratory epithelium morphology (HP:0012253)4.66074961
13Rhinitis (HP:0012384)4.43956165
14Abnormality of macular pigmentation (HP:0008002)4.37398005
15Hyperkalemia (HP:0002153)4.35518464
16Amelogenesis imperfecta (HP:0000705)4.30467990
17Resting tremor (HP:0002322)4.23857900
18Chronic bronchitis (HP:0004469)4.15580932
19Infertility (HP:0000789)4.14162052
20Cone-rod dystrophy (HP:0000548)4.07131715
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.05960642
22Potter facies (HP:0002009)3.93283480
23Facial shape deformation (HP:0011334)3.93283480
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.92123862
25Bell-shaped thorax (HP:0001591)3.91053002
26Myoglobinuria (HP:0002913)3.83685797
27Hypoplasia of the thymus (HP:0000778)3.72284660
28Impulsivity (HP:0100710)3.67009940
29Exercise-induced myalgia (HP:0003738)3.55046879
30Abnormal ciliary motility (HP:0012262)3.45346075
31Ventricular tachycardia (HP:0004756)3.43436412
32Enlarged epiphyses (HP:0010580)3.33214442
33Hepatic necrosis (HP:0002605)3.31242533
34Abnormal rod and cone electroretinograms (HP:0008323)3.30751586
35Rhabdomyolysis (HP:0003201)3.28847537
36Sudden death (HP:0001699)3.26275696
37Hypoalphalipoproteinemia (HP:0003233)3.19873536
38Postural instability (HP:0002172)3.18056373
39Bundle branch block (HP:0011710)3.16020731
40Exercise-induced muscle cramps (HP:0003710)3.04242062
41Portal hypertension (HP:0001409)3.03403059
42Dicarboxylic aciduria (HP:0003215)3.02903715
43Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02903715
44Progressive cerebellar ataxia (HP:0002073)3.01658134
45Tubulointerstitial abnormality (HP:0001969)3.00388939
46Atrial fibrillation (HP:0005110)2.99016627
47Abnormality of the ischium (HP:0003174)2.97140342
48Menstrual irregularities (HP:0000858)2.91899616
49Nasal polyposis (HP:0100582)2.90771574
50Stage 5 chronic kidney disease (HP:0003774)2.90519586
51Progressive sensorineural hearing impairment (HP:0000408)2.89817628
52Truncal obesity (HP:0001956)2.88411249
53Abnormal spermatogenesis (HP:0008669)2.84857581
54Hepatocellular necrosis (HP:0001404)2.83579908
55Acute necrotizing encephalopathy (HP:0006965)2.80450290
56Muscle fiber splitting (HP:0003555)2.79708222
57Abnormality of dental color (HP:0011073)2.78130836
58Abnormality of the hepatic vasculature (HP:0006707)2.77012312
59Abnormal gallbladder physiology (HP:0012438)2.75248475
60Cholecystitis (HP:0001082)2.75248475
61Abnormal urine output (HP:0012590)2.74523080
62Abnormal mitochondria in muscle tissue (HP:0008316)2.74503943
63Abnormality of lateral ventricle (HP:0030047)2.73693246
64Acute encephalopathy (HP:0006846)2.71410996
65Irregular epiphyses (HP:0010582)2.68634786
66Primary atrial arrhythmia (HP:0001692)2.67967285
67Ketosis (HP:0001946)2.67406282
68Lipoatrophy (HP:0100578)2.67182789
69Abnormality of fatty-acid metabolism (HP:0004359)2.64258914
70Hyporeflexia of lower limbs (HP:0002600)2.64035917
71Supraventricular tachycardia (HP:0004755)2.63451388
72Nephronophthisis (HP:0000090)2.61765073
73Palpitations (HP:0001962)2.59126013
74Renovascular hypertension (HP:0100817)2.56464485
75Insulin-resistant diabetes mellitus (HP:0000831)2.55741106
76Hypoglycemic coma (HP:0001325)2.55615382
77Calf muscle hypertrophy (HP:0008981)2.54184352
78Supraventricular arrhythmia (HP:0005115)2.53088974
79Abnormality of potassium homeostasis (HP:0011042)2.53069781
80Polydipsia (HP:0001959)2.52556191
81Abnormal drinking behavior (HP:0030082)2.52556191
82Cerebral edema (HP:0002181)2.52306508
83Abnormality of the nasal mucosa (HP:0000433)2.51216841
84Intellectual disability, moderate (HP:0002342)2.48797177
85Heart block (HP:0012722)2.47804955
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.46854030
87Generalized aminoaciduria (HP:0002909)2.45114779
88Metaphyseal cupping (HP:0003021)2.42314686
89Abnormality of the costochondral junction (HP:0000919)2.36705221
90Bronchitis (HP:0012387)2.36241518
91Abnormality of renal excretion (HP:0011036)2.35028230
92Abnormality of serine family amino acid metabolism (HP:0010894)2.34189390
93Abnormality of glycine metabolism (HP:0010895)2.34189390
94Neonatal hypoglycemia (HP:0001998)2.33697481
95Dilated cardiomyopathy (HP:0001644)2.29366601
96Metaphyseal dysplasia (HP:0100255)2.28172077
97Polyuria (HP:0000103)2.27746075
98Atrioventricular block (HP:0001678)2.26811114
99Increased CSF lactate (HP:0002490)2.26403418
100Abnormal atrioventricular conduction (HP:0005150)2.25800564
101Mitochondrial inheritance (HP:0001427)2.24800583
102Methylmalonic acidemia (HP:0002912)2.24795632
103Hyperuricemia (HP:0002149)2.24485438
104Increased purine levels (HP:0004368)2.24485438
105Hyperglycinuria (HP:0003108)2.24044389
106Hyperglycinemia (HP:0002154)2.23860216
107* Asymmetric septal hypertrophy (HP:0001670)2.22141770
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21827423
109Bronchiectasis (HP:0002110)2.21780679
110Azoospermia (HP:0000027)2.21212778
111Renal dysplasia (HP:0000110)2.20967049
112Methylmalonic aciduria (HP:0012120)2.20760056
113Abnormality of the aortic arch (HP:0012303)2.19766511
114Progressive macrocephaly (HP:0004481)2.19721354
115Lactic acidosis (HP:0003128)2.18852306
116Unilateral renal agenesis (HP:0000122)2.17744949
117Muscle hypertrophy of the lower extremities (HP:0008968)2.16288922
118Abnormality of the calf musculature (HP:0001430)2.14976092
119Tubular atrophy (HP:0000092)2.14904174
120Left ventricular hypertrophy (HP:0001712)2.14683711
121Ketoacidosis (HP:0001993)2.14480577
122Double outlet right ventricle (HP:0001719)2.10838783
123Congenital malformation of the right heart (HP:0011723)2.10838783
124Ventricular arrhythmia (HP:0004308)2.10125483
125Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09354661
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09354661
127Increased muscle lipid content (HP:0009058)2.08723214
128Difficulty running (HP:0009046)2.08392452
129Bile duct proliferation (HP:0001408)2.08246689
130Abnormal biliary tract physiology (HP:0012439)2.08246689
131Hyperammonemia (HP:0001987)2.07493793
132Pendular nystagmus (HP:0012043)2.06925327
133Right ventricular cardiomyopathy (HP:0011663)2.05789847
134Subcapsular cataract (HP:0000523)2.03443763
135Osteomalacia (HP:0002749)2.02368090
136Hypophosphatemic rickets (HP:0004912)2.01916681
137Increased serum pyruvate (HP:0003542)2.00676407
138Abnormality of glycolysis (HP:0004366)2.00676407
139Areflexia of lower limbs (HP:0002522)1.99922296
140Pancreatic fibrosis (HP:0100732)1.99040039
141Abnormality of femoral epiphyses (HP:0006499)1.98865001
142Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.98865001
143Lethargy (HP:0001254)1.97271227
144Optic nerve hypoplasia (HP:0000609)1.97178337
145Epiphyseal dysplasia (HP:0002656)1.96016234
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95661685
147Absent epiphyses (HP:0010577)1.95661685
148Abnormality of the epiphysis of the femoral head (HP:0010574)1.94945764
149Renal Fanconi syndrome (HP:0001994)1.94799183
150Flattened epiphyses (HP:0003071)1.93450526
151Syncope (HP:0001279)1.92980762
152Abnormality of the femoral head (HP:0003368)1.89912951
153Hypoplastic ischia (HP:0003175)1.89386911
154Photophobia (HP:0000613)1.87872587
155Abnormality of the renal cortex (HP:0011035)1.87346017
156Myokymia (HP:0002411)1.86976979
157Decreased central vision (HP:0007663)1.86687695
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86321446
159Respiratory failure (HP:0002878)1.86060424
160Sandal gap (HP:0001852)1.85740587
161Widely patent fontanelles and sutures (HP:0004492)1.82265419
162Focal segmental glomerulosclerosis (HP:0000097)1.81980586
163Occipital encephalocele (HP:0002085)1.81733204
164Recurrent pneumonia (HP:0006532)1.81087029
165Progressive hearing impairment (HP:0001730)1.80773284
166Spastic paraparesis (HP:0002313)1.80624536
167Hypoalbuminemia (HP:0003073)1.80602514
168Abnormal albumin level (HP:0012116)1.80602514
169Hyponatremia (HP:0002902)1.79787247
170Abnormality of the parathyroid morphology (HP:0011766)1.79509175
171Horizontal nystagmus (HP:0000666)1.78075237
172Recurrent otitis media (HP:0000403)1.77960825
173Abnormality of the renal medulla (HP:0100957)1.77875934
174Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77607498
175Convex nasal ridge (HP:0000444)1.70613188
176Congenital sensorineural hearing impairment (HP:0008527)1.70319797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.73537355
2PDK47.73537355
3PDK24.84738858
4LMTK24.10441719
5DDR23.96087001
6INSRR3.95009272
7BRD43.72190420
8PLK23.64361898
9PRKD33.49018383
10PNCK3.01846737
11MUSK2.60664472
12PHKG12.32843905
13PHKG22.32843905
14MAP4K22.30126707
15BCKDK2.29577634
16CAMK1G2.27461988
17PIK3CG2.10423087
18TTN2.10400710
19TESK12.04251618
20STK38L2.02736122
21MAPK151.91537061
22LATS11.80344633
23BUB11.55866550
24ICK1.47682588
25MST1R1.45852316
26NEK11.41133055
27PLK41.37869203
28TTK1.37821880
29WNK11.36278594
30PINK11.36082852
31NEK61.31181730
32TYRO31.19545534
33CDK121.19040656
34NEK21.15524817
35WNK41.14760249
36BRAF1.11128758
37TRIB31.08859750
38WEE11.08855738
39MAP3K61.07427082
40CDK71.06441956
41LATS21.01052682
42TIE10.99698143
43EIF2AK10.95257728
44STK390.91116354
45BRSK20.89488797
46CAMK1D0.88181054
47MYLK0.87504600
48STK240.87445298
49EEF2K0.86722474
50ZAK0.86168876
51BMPR1B0.85054047
52MAP3K40.84094053
53ERBB40.83250811
54OBSCN0.83027585
55MAP2K20.79813788
56PTK2B0.78986521
57AKT30.76770857
58STK30.75178766
59ARAF0.74952740
60CDK80.71442801
61CDK30.69114768
62MOS0.68400129
63PRKAA10.67525547
64TAF10.63528434
65KSR20.63111588
66PKN20.61489752
67MAP3K20.61093402
68STK380.58092595
69CHEK20.57933248
70NME10.57265217
71MAP3K90.56243998
72PLK10.56155741
73NEK90.55761050
74PDK10.54499574
75PRKG10.53905739
76BRSK10.53727368
77MAP3K110.53043187
78GRK70.52100681
79FRK0.51328898
80SIK20.50914624
81CDC70.50709507
82DMPK0.49425589
83MAPKAPK30.48242080
84RPS6KA10.48002975
85PRKAA20.47774228
86ACVR1B0.46955704
87UHMK10.46728412
88CDK20.46382327
89CAMK10.44855271
90PAK30.43879481
91CDK10.43173534
92TAOK30.42899467
93OXSR10.41515014
94STK40.41495915
95PRKCG0.41363577
96RPS6KA20.41280543
97GSK3B0.39782385
98AURKB0.39155118
99MAPKAPK50.38418605
100MAP3K50.38318577
101MAPK10.38297127
102FLT30.36190179
103TNIK0.35648687
104CDK190.35332544
105ABL20.34023766
106MKNK20.33403174
107RAF10.33018640
108TAOK10.32637965
109PRKG20.32296904
110CHEK10.30591366
111PIK3CA0.29440285
112KIT0.29105337
113IRAK10.27867883
114CDK90.27481852
115SGK4940.27222116
116SGK2230.27222116
117STK100.26621496
118MAPK80.26136629
119DYRK1B0.25227492
120WNK30.25072556
121EIF2AK30.24026512
122PDPK10.23299851
123MAPK120.23030492
124JAK30.22811690
125CDK40.22374776
126CAMK2A0.22300054
127MARK10.21531122
128SGK10.21424887
129PBK0.20944439
130NLK0.20922306
131MAPK110.20893107
132AURKA0.20810054
133RPS6KC10.20599781
134RPS6KL10.20599781
135MAPK140.20407414
136PRKCB0.20279895
137PRKACB0.20155569
138MAP3K30.19694753
139TESK20.19668969
140RPS6KA60.19350351
141MTOR0.19344069
142PRKCZ0.19306071
143SGK20.18634668
144NTRK30.18144111
145ROCK10.17412567
146MAP3K10.17281149
147MET0.16784997
148TRPM70.16414429
149MAP3K80.15883191
150ATM0.14823353
151PAK10.14787817
152PRKACA0.14697692
153ILK0.14142352
154MAP2K70.13869641
155PASK0.13312647
156CAMK40.13251400
157PRKACG0.12770604
158MAP2K60.12697286
159PRKD10.12565824
160VRK10.11961414
161AKT10.11823806
162ATR0.11405298
163PKN10.10555477
164MAP2K10.09654091
165MELK0.09560071
166PRKCE0.09291236
167MAPK100.09141985

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006404.38965183
2Olfactory transduction_Homo sapiens_hsa047403.98627363
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.86108039
4Fatty acid degradation_Homo sapiens_hsa000713.65025255
5Pyruvate metabolism_Homo sapiens_hsa006203.31417240
6Fatty acid metabolism_Homo sapiens_hsa012123.01672875
7Vitamin B6 metabolism_Homo sapiens_hsa007502.73012056
8Fatty acid biosynthesis_Homo sapiens_hsa000612.68128807
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.62770774
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57406580
11Carbon metabolism_Homo sapiens_hsa012002.44710197
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23777252
13Taste transduction_Homo sapiens_hsa047422.16832526
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11661316
15PPAR signaling pathway_Homo sapiens_hsa033202.04244702
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01505656
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00041338
18Cardiac muscle contraction_Homo sapiens_hsa042601.73906547
19Phototransduction_Homo sapiens_hsa047441.73007383
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69084622
21Biosynthesis of amino acids_Homo sapiens_hsa012301.64915532
22Butanoate metabolism_Homo sapiens_hsa006501.60981856
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60391801
24Fatty acid elongation_Homo sapiens_hsa000621.59894699
25Basal transcription factors_Homo sapiens_hsa030221.58721753
26Huntingtons disease_Homo sapiens_hsa050161.58479013
27Oxidative phosphorylation_Homo sapiens_hsa001901.53299040
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47270729
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42938835
30Parkinsons disease_Homo sapiens_hsa050121.41202142
31Tryptophan metabolism_Homo sapiens_hsa003801.39163364
32Peroxisome_Homo sapiens_hsa041461.38460951
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.36294844
34Type II diabetes mellitus_Homo sapiens_hsa049301.34075234
35Selenocompound metabolism_Homo sapiens_hsa004501.33841084
36Nicotine addiction_Homo sapiens_hsa050331.30108905
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29435752
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27986278
39Linoleic acid metabolism_Homo sapiens_hsa005911.26428582
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26053091
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24854860
42Glucagon signaling pathway_Homo sapiens_hsa049221.22250334
43ABC transporters_Homo sapiens_hsa020101.19642360
44Fructose and mannose metabolism_Homo sapiens_hsa000511.18604050
45Pentose phosphate pathway_Homo sapiens_hsa000301.18172136
46Protein digestion and absorption_Homo sapiens_hsa049741.12193258
47Glycerolipid metabolism_Homo sapiens_hsa005611.11201954
48Hedgehog signaling pathway_Homo sapiens_hsa043401.07906122
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06306884
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05971600
51Calcium signaling pathway_Homo sapiens_hsa040201.05348726
52Morphine addiction_Homo sapiens_hsa050321.05154441
53Type I diabetes mellitus_Homo sapiens_hsa049401.04969317
54Synaptic vesicle cycle_Homo sapiens_hsa047211.00215178
55Antigen processing and presentation_Homo sapiens_hsa046120.95141617
56Arginine and proline metabolism_Homo sapiens_hsa003300.94710435
57Alzheimers disease_Homo sapiens_hsa050100.93614082
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92967050
59Glutathione metabolism_Homo sapiens_hsa004800.92030334
60Inositol phosphate metabolism_Homo sapiens_hsa005620.91140150
61Phenylalanine metabolism_Homo sapiens_hsa003600.90851677
62beta-Alanine metabolism_Homo sapiens_hsa004100.89835059
63Salivary secretion_Homo sapiens_hsa049700.89333393
64Allograft rejection_Homo sapiens_hsa053300.88891191
65Sulfur metabolism_Homo sapiens_hsa009200.87784595
66Autoimmune thyroid disease_Homo sapiens_hsa053200.86156173
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86036165
68cAMP signaling pathway_Homo sapiens_hsa040240.84902953
69Folate biosynthesis_Homo sapiens_hsa007900.82027085
70Metabolic pathways_Homo sapiens_hsa011000.81789900
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81629402
72RNA transport_Homo sapiens_hsa030130.81536373
73Nitrogen metabolism_Homo sapiens_hsa009100.81271249
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.81077080
75Sulfur relay system_Homo sapiens_hsa041220.80973848
76Viral myocarditis_Homo sapiens_hsa054160.80593603
77Tyrosine metabolism_Homo sapiens_hsa003500.79880559
78Purine metabolism_Homo sapiens_hsa002300.77759467
79Cell cycle_Homo sapiens_hsa041100.77604983
80RNA degradation_Homo sapiens_hsa030180.77441869
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.76794305
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75774792
83Chemical carcinogenesis_Homo sapiens_hsa052040.75155287
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74924160
85RNA polymerase_Homo sapiens_hsa030200.74583757
86Glutamatergic synapse_Homo sapiens_hsa047240.74242390
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74186528
88Oocyte meiosis_Homo sapiens_hsa041140.73645460
89Graft-versus-host disease_Homo sapiens_hsa053320.73527710
90Proteasome_Homo sapiens_hsa030500.72277793
91Starch and sucrose metabolism_Homo sapiens_hsa005000.72199950
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.72153109
93Pyrimidine metabolism_Homo sapiens_hsa002400.71568728
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70563437
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69232979
96Renin-angiotensin system_Homo sapiens_hsa046140.67662210
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66929135
98Arginine biosynthesis_Homo sapiens_hsa002200.66565654
99Retinol metabolism_Homo sapiens_hsa008300.65242059
100Steroid biosynthesis_Homo sapiens_hsa001000.64973531
101Endocytosis_Homo sapiens_hsa041440.63906693
102Circadian entrainment_Homo sapiens_hsa047130.63275658
103Base excision repair_Homo sapiens_hsa034100.62419777
104Non-homologous end-joining_Homo sapiens_hsa034500.61271536
105Serotonergic synapse_Homo sapiens_hsa047260.60999588
106Dilated cardiomyopathy_Homo sapiens_hsa054140.60064342
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.58040986
108VEGF signaling pathway_Homo sapiens_hsa043700.56285845
109Ether lipid metabolism_Homo sapiens_hsa005650.55537731
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54835822
111Ovarian steroidogenesis_Homo sapiens_hsa049130.53554598
112Histidine metabolism_Homo sapiens_hsa003400.52588758
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52230271
114Influenza A_Homo sapiens_hsa051640.52103978
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50980156
116Gastric acid secretion_Homo sapiens_hsa049710.50275022
117Estrogen signaling pathway_Homo sapiens_hsa049150.48397246
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48390534
119GABAergic synapse_Homo sapiens_hsa047270.47126633
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47085061
121Fat digestion and absorption_Homo sapiens_hsa049750.45358734
122Circadian rhythm_Homo sapiens_hsa047100.44975828
123Homologous recombination_Homo sapiens_hsa034400.41897463
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41585669
125Galactose metabolism_Homo sapiens_hsa000520.41441342
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41396837
127Arachidonic acid metabolism_Homo sapiens_hsa005900.40841040
128DNA replication_Homo sapiens_hsa030300.40350776
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39748834
130Insulin secretion_Homo sapiens_hsa049110.39725409
131mRNA surveillance pathway_Homo sapiens_hsa030150.38368968
132Pancreatic secretion_Homo sapiens_hsa049720.38160774
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35829738
134Bile secretion_Homo sapiens_hsa049760.35478739
135Fanconi anemia pathway_Homo sapiens_hsa034600.35171691
136ECM-receptor interaction_Homo sapiens_hsa045120.34553529
137Cholinergic synapse_Homo sapiens_hsa047250.34044959
138Nucleotide excision repair_Homo sapiens_hsa034200.33940070
139Insulin resistance_Homo sapiens_hsa049310.33120796
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32533640
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32270924
142Tight junction_Homo sapiens_hsa045300.29761062
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27953563
144Dorso-ventral axis formation_Homo sapiens_hsa043200.27133520
145One carbon pool by folate_Homo sapiens_hsa006700.27056647
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26451468
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26444100
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.25641042
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24807926
150Lysine degradation_Homo sapiens_hsa003100.24538897
151Vitamin digestion and absorption_Homo sapiens_hsa049770.24472326
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24430626
153Renin secretion_Homo sapiens_hsa049240.22667526
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.22281529

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