ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	7.37017393
2	sperm motility (GO:0030317)	6.93050680
3	protein polyglutamylation (GO:0018095)	6.75568556
4	protein targeting to Golgi (GO:0000042)	6.05313130
5	establishment of protein localization to Golgi (GO:0072600)	5.96771656
6	regulation of cilium movement (GO:0003352)	5.95793472
7	male meiosis I (GO:0007141)	5.91395735
8	male meiosis (GO:0007140)	5.80785087
9	hematopoietic stem cell differentiation (GO:0060218)	5.73726189
10	piRNA metabolic process (GO:0034587)	5.60605037
11	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.52825121
12	DNA methylation involved in gamete generation (GO:0043046)	5.51773841
13	seminiferous tubule development (GO:0072520)	5.46386073
14	fusion of sperm to egg plasma membrane (GO:0007342)	5.21388903
15	chromosome organization involved in meiosis (GO:0070192)	5.04051976
16	glomerular visceral epithelial cell development (GO:0072015)	5.01390674
17	spermatid development (GO:0007286)	4.99487320
18	mesenchymal cell differentiation involved in renal system development (GO:2001012)	4.79229812
19	mesenchymal cell differentiation involved in kidney development (GO:0072161)	4.79229812
20	DNA packaging (GO:0006323)	4.74209032
21	acrosome reaction (GO:0007340)	4.71397819
22	meiosis I (GO:0007127)	4.54121924
23	response to pheromone (GO:0019236)	4.46351686
24	chromosome condensation (GO:0030261)	4.46172934
25	glomerular epithelial cell development (GO:0072310)	4.42521662
26	regulation of centriole replication (GO:0046599)	4.42291158
27	protein localization to Golgi apparatus (GO:0034067)	4.40901971
28	acrosome assembly (GO:0001675)	4.34006898
29	glycerol metabolic process (GO:0006071)	4.26223553
30	centriole replication (GO:0007099)	4.24115000
31	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.19304074
32	synaptonemal complex assembly (GO:0007130)	4.10846920
33	meiotic nuclear division (GO:0007126)	4.08983927
34	peptidyl-glutamic acid modification (GO:0018200)	4.06107105
35	COPII vesicle coating (GO:0048208)	4.03064488
36	spermatogenesis (GO:0007283)	3.99019266
37	male gamete generation (GO:0048232)	3.98307725
38	DNA synthesis involved in DNA repair (GO:0000731)	3.96615743
39	synaptonemal complex organization (GO:0070193)	3.95473989
40	nucleoside diphosphate catabolic process (GO:0009134)	3.85140171
41	amino acid salvage (GO:0043102)	3.83754649
42	L-methionine salvage (GO:0071267)	3.83754649
43	L-methionine biosynthetic process (GO:0071265)	3.83754649
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.82128870
45	methionine biosynthetic process (GO:0009086)	3.80191703
46	cilium or flagellum-dependent cell motility (GO:0001539)	3.79530968
47	regulation of microtubule-based movement (GO:0060632)	3.79475946
48	polyol catabolic process (GO:0046174)	3.72943053
49	alditol metabolic process (GO:0019400)	3.70562658
50	gamete generation (GO:0007276)	3.67453663
51	positive regulation of protein targeting to membrane (GO:0090314)	3.67308538
52	plasma membrane fusion (GO:0045026)	3.65398098
53	centriole assembly (GO:0098534)	3.63834910
54	RNA localization (GO:0006403)	3.63817754
55	sperm-egg recognition (GO:0035036)	3.58742752
56	ether metabolic process (GO:0018904)	3.54702297
57	phosphatidylethanolamine metabolic process (GO:0046337)	3.51648306
58	detection of light stimulus involved in visual perception (GO:0050908)	3.51457217
59	detection of light stimulus involved in sensory perception (GO:0050962)	3.51457217
60	positive regulation of meiosis (GO:0045836)	3.50142488
61	glycerol ether metabolic process (GO:0006662)	3.50079486
62	regulation of meiosis I (GO:0060631)	3.48346772
63	xenobiotic catabolic process (GO:0042178)	3.46097574
64	peptidyl-lysine dimethylation (GO:0018027)	3.43739935
65	sulfate transmembrane transport (GO:1902358)	3.38789718
66	cellular ketone body metabolic process (GO:0046950)	3.35738524
67	microtubule polymerization or depolymerization (GO:0031109)	3.33461779
68	tRNA methylation (GO:0030488)	3.31272158
69	aspartate family amino acid biosynthetic process (GO:0009067)	3.30612498
70	positive regulation of meiotic cell cycle (GO:0051446)	3.29716007
71	Golgi to endosome transport (GO:0006895)	3.28444820
72	protein carboxylation (GO:0018214)	3.28189991
73	peptidyl-glutamic acid carboxylation (GO:0017187)	3.28189991
74	cell differentiation involved in metanephros development (GO:0072202)	3.27124706
75	intra-Golgi vesicle-mediated transport (GO:0006891)	3.24011943
76	mitochondrial genome maintenance (GO:0000002)	3.23726299
77	negative regulation of inclusion body assembly (GO:0090084)	3.23209287
78	germ cell development (GO:0007281)	3.22013145
79	regulation of metalloenzyme activity (GO:0048552)	3.21857373
80	regulation of synapse maturation (GO:0090128)	3.19385678
81	TOR signaling (GO:0031929)	3.18050386
82	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.16202057
83	binding of sperm to zona pellucida (GO:0007339)	3.16193244
84	microtubule depolymerization (GO:0007019)	3.15392790
85	proline biosynthetic process (GO:0006561)	3.11444742
86	meiotic cell cycle process (GO:1903046)	3.09820077
87	multicellular organism reproduction (GO:0032504)	3.07075233
88	regulation of neurotransmitter uptake (GO:0051580)	3.03986757
89	axoneme assembly (GO:0035082)	3.03880275
90	peptidyl-lysine trimethylation (GO:0018023)	3.00541514
91	somite rostral/caudal axis specification (GO:0032525)	2.97451494
92	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.96283472
93	coenzyme catabolic process (GO:0009109)	2.94205716
94	methionine metabolic process (GO:0006555)	2.93886339
95	negative regulation of hormone biosynthetic process (GO:0032353)	2.93586912
96	lipoprotein transport (GO:0042953)	2.93491289
97	fertilization (GO:0009566)	2.92340406
98	ketone body metabolic process (GO:1902224)	2.91535656
99	cell-cell recognition (GO:0009988)	2.91320058
100	spermatid nucleus differentiation (GO:0007289)	2.91115485

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.60285564
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.51944781
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.26329218
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.99749691
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84258482
6	ER_23166858_ChIP-Seq_MCF-7_Human	2.64300572
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.59666838
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.44718721
9	ELK4_26923725_Chip-Seq_MESODERM_Mouse	2.38931894
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.36798220
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.29417117
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.28496855
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.22363893
14	FUS_26573619_Chip-Seq_HEK293_Human	2.08536139
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.07363373
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.00567510
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83000775
18	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.81997709
19	ERG_20517297_ChIP-Seq_VCAP_Human	1.80564648
20	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.78120648
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.75259984
22	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.74741439
23	ERA_21632823_ChIP-Seq_H3396_Human	1.68675017
24	AHR_22903824_ChIP-Seq_MCF-7_Human	1.61752451
25	VDR_22108803_ChIP-Seq_LS180_Human	1.61013848
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.57457538
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.56226692
28	HOXB7_26014856_ChIP-Seq_BT474_Human	1.54700391
29	RBPJ_21746931_ChIP-Seq_IB4_Human	1.52627578
30	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.52462010
31	ETV1_20927104_ChIP-Seq_GIST48_Human	1.50693210
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.47645552
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.44535576
34	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42549366
35	RAC3_21632823_ChIP-Seq_H3396_Human	1.41515660
36	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.39676621
37	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.38739524
38	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.37283204
39	MYC_19829295_ChIP-Seq_ESCs_Human	1.36621579
40	CEBPB_22108803_ChIP-Seq_LS180_Human	1.34851170
41	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.30724560
42	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.30085480
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29834591
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29702079
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27849677
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27849677
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25977780
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25977780
49	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.25941257
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23199433
51	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.23121545
52	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22228764
53	STAT3_23295773_ChIP-Seq_U87_Human	1.18945947
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.18878434
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17812004
56	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.17433518
57	PHF8_20622853_ChIP-Seq_HELA_Human	1.16554268
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14694497
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14694497
60	E2F1_20622854_ChIP-Seq_HELA_Human	1.13364695
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.12861965
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12861965
63	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.12319368
64	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.12319368
65	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.12319368
66	AR_25329375_ChIP-Seq_VCAP_Human	1.11845309
67	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.11554985
68	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.11423667
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11004020
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10805747
71	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.10139470
72	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.09930678
73	NFYB_21822215_ChIP-Seq_K562_Human	1.08438279
74	P300_19829295_ChIP-Seq_ESCs_Human	1.08277629
75	NCOR_22424771_ChIP-Seq_293T_Human	1.07303123
76	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.06984032
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06810305
78	TP53_22573176_ChIP-Seq_HFKS_Human	1.06259318
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05373498
80	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04525390
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03600567
82	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.02650608
83	TBL1_22424771_ChIP-Seq_293T_Human	1.00902997
84	KLF5_25053715_ChIP-Seq_YYC3_Human	1.00206823
85	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.99969321
86	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99322355
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98674605
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98643700
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98558019
90	P300_27268052_Chip-Seq_Bcells_Human	0.98445322
91	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.97137193
92	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.96776239
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96451850
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96342684
95	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.94547939
96	BCL6_27268052_Chip-Seq_Bcells_Human	0.93972778
97	GATA6_25053715_ChIP-Seq_YYC3_Human	0.93686052
98	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93254292
99	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92670903
100	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.92575533

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008004_abnormal_stomach_pH	6.13308731
2	MP0000013_abnormal_adipose_tissue	5.87844824
3	MP0005410_abnormal_fertilization	4.56233040
4	MP0008995_early_reproductive_senescence	3.89442235
5	MP0000003_abnormal_adipose_tissue	3.68744219
6	MP0008961_abnormal_basal_metabolism	3.28738888
7	MP0006054_spinal_hemorrhage	2.88642274
8	MP0008877_abnormal_DNA_methylation	2.56717651
9	MP0001929_abnormal_gametogenesis	2.38798814
10	MP0001501_abnormal_sleep_pattern	2.37365235
11	MP0005377_hearing/vestibular/ear_phenot	2.32017076
12	MP0003878_abnormal_ear_physiology	2.32017076
13	MP0003698_abnormal_male_reproductive	2.31200392
14	MP0001502_abnormal_circadian_rhythm	2.21480190
15	MP0002928_abnormal_bile_duct	2.11738292
16	MP0002210_abnormal_sex_determination	2.00538126
17	MP0004233_abnormal_muscle_weight	1.92948252
18	MP0003786_premature_aging	1.91483559
19	MP0003123_paternal_imprinting	1.82241022
20	MP0002160_abnormal_reproductive_system	1.78942563
21	MP0005083_abnormal_biliary_tract	1.67008481
22	MP0005375_adipose_tissue_phenotype	1.64602834
23	MP0005551_abnormal_eye_electrophysiolog	1.59478165
24	MP0005365_abnormal_bile_salt	1.59304274
25	MP0000383_abnormal_hair_follicle	1.55568945
26	MP0000653_abnormal_sex_gland	1.53287732
27	MP0005379_endocrine/exocrine_gland_phen	1.51339127
28	MP0002161_abnormal_fertility/fecundity	1.49416738
29	MP0004147_increased_porphyrin_level	1.48672861
30	MP0004019_abnormal_vitamin_homeostasis	1.48531390
31	MP0005310_abnormal_salivary_gland	1.46113956
32	MP0008875_abnormal_xenobiotic_pharmacok	1.44688491
33	MP0001145_abnormal_male_reproductive	1.44245640
34	MP0003718_maternal_effect	1.37116459
35	MP0008058_abnormal_DNA_repair	1.34252168
36	MP0005332_abnormal_amino_acid	1.33120100
37	MP0004133_heterotaxia	1.30094691
38	MP0009697_abnormal_copulation	1.30069731
39	MP0004264_abnormal_extraembryonic_tissu	1.25790354
40	MP0005636_abnormal_mineral_homeostasis	1.25144248
41	MP0005646_abnormal_pituitary_gland	1.22873471
42	MP0000427_abnormal_hair_cycle	1.19727230
43	MP0005397_hematopoietic_system_phenotyp	1.13652347
44	MP0001545_abnormal_hematopoietic_system	1.13652347
45	MP0010329_abnormal_lipoprotein_level	1.13443055
46	MP0001485_abnormal_pinna_reflex	1.12867723
47	MP0005670_abnormal_white_adipose	1.12414559
48	MP0001666_abnormal_nutrient_absorption	1.10392940
49	MP0001944_abnormal_pancreas_morphology	1.09962714
50	MP0009115_abnormal_fat_cell	1.07757274
51	MP0003183_abnormal_peptide_metabolism	1.07589714
52	MP0003943_abnormal_hepatobiliary_system	1.06613597
53	MP0004484_altered_response_of	1.02858051
54	MP0005187_abnormal_penis_morphology	1.01852328
55	MP0005389_reproductive_system_phenotype	0.99559905
56	MP0003646_muscle_fatigue	0.98493845
57	MP0000647_abnormal_sebaceous_gland	0.94217794
58	MP0005451_abnormal_body_composition	0.93429654
59	MP0001984_abnormal_olfaction	0.91503652
60	MP0000569_abnormal_digit_pigmentation	0.90358315
61	MP0009046_muscle_twitch	0.88827253
62	MP0001661_extended_life_span	0.83930600
63	MP0003936_abnormal_reproductive_system	0.83365369
64	MP0009780_abnormal_chondrocyte_physiolo	0.82614732
65	MP0000470_abnormal_stomach_morphology	0.78785335
66	MP0000371_diluted_coat_color	0.77015970
67	MP0008872_abnormal_physiological_respon	0.76560540
68	MP0001486_abnormal_startle_reflex	0.75517158
69	MP0001765_abnormal_ion_homeostasis	0.74961531
70	MP0006036_abnormal_mitochondrial_physio	0.74247523
71	MP0000613_abnormal_salivary_gland	0.74157299
72	MP0002139_abnormal_hepatobiliary_system	0.73974507
73	MP0002118_abnormal_lipid_homeostasis	0.73842893
74	MP0004782_abnormal_surfactant_physiolog	0.73466203
75	MP0003077_abnormal_cell_cycle	0.73460440
76	MP0004742_abnormal_vestibular_system	0.73033689
77	MP0000358_abnormal_cell_content/	0.72785646
78	MP0005167_abnormal_blood-brain_barrier	0.72709323
79	MP0001764_abnormal_homeostasis	0.72322968
80	MP0002909_abnormal_adrenal_gland	0.71921481
81	MP0002132_abnormal_respiratory_system	0.71030135
82	MP0005253_abnormal_eye_physiology	0.70490629
83	MP0009765_abnormal_xenobiotic_induced	0.69761064
84	MP0000631_abnormal_neuroendocrine_gland	0.68409036
85	MP0002078_abnormal_glucose_homeostasis	0.67735785
86	MP0010678_abnormal_skin_adnexa	0.67147306
87	MP0003699_abnormal_female_reproductive	0.66969371
88	MP0001986_abnormal_taste_sensitivity	0.66877117
89	MP0003879_abnormal_hair_cell	0.66826240
90	MP0002736_abnormal_nociception_after	0.66682031
91	MP0002229_neurodegeneration	0.65750524
92	MP0005360_urolithiasis	0.64799987
93	MP0005085_abnormal_gallbladder_physiolo	0.64589942
94	MP0002837_dystrophic_cardiac_calcinosis	0.64419721
95	MP0000609_abnormal_liver_physiology	0.62831405
96	MP0003938_abnormal_ear_development	0.61063998
97	MP0002653_abnormal_ependyma_morphology	0.60582619
98	MP0002970_abnormal_white_adipose	0.60129289
99	MP0004924_abnormal_behavior	0.59522415
100	MP0005386_behavior/neurological_phenoty	0.59522415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	4.53221979
2	Generalized hypopigmentation of hair (HP:0011358)	4.25962315
3	Abnormality of the renal cortex (HP:0011035)	4.24737902
4	Calf muscle hypertrophy (HP:0008981)	4.23323314
5	Shoulder girdle muscle weakness (HP:0003547)	4.16372654
6	Prominent supraorbital ridges (HP:0000336)	3.75935238
7	Prolonged partial thromboplastin time (HP:0003645)	3.71595129
8	Muscle hypertrophy of the lower extremities (HP:0008968)	3.69749243
9	Abnormal gallbladder physiology (HP:0012438)	3.67358073
10	Cholecystitis (HP:0001082)	3.67358073
11	Severe visual impairment (HP:0001141)	3.38177454
12	Renal cortical cysts (HP:0000803)	3.34472519
13	Cone-rod dystrophy (HP:0000548)	3.21975938
14	Abnormality of lateral ventricle (HP:0030047)	3.19344599
15	Joint hemorrhage (HP:0005261)	3.08294300
16	Abnormality of macular pigmentation (HP:0008002)	3.02627799
17	Aplasia/hypoplasia of the uterus (HP:0008684)	3.00661834
18	Protruding tongue (HP:0010808)	2.95283515
19	Delayed CNS myelination (HP:0002188)	2.84565133
20	Tubulointerstitial nephritis (HP:0001970)	2.81606457
21	Abnormality of the renal medulla (HP:0100957)	2.80219068
22	Unsteady gait (HP:0002317)	2.79847813
23	Proximal amyotrophy (HP:0007126)	2.72890643
24	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.71520284
25	Hypoplasia of the fovea (HP:0007750)	2.71520284
26	Increased serum pyruvate (HP:0003542)	2.65993478
27	Anterior segment dysgenesis (HP:0007700)	2.63842156
28	Acanthocytosis (HP:0001927)	2.63824791
29	Pelvic girdle muscle weakness (HP:0003749)	2.62878470
30	Abnormality of glycolysis (HP:0004366)	2.60934557
31	Pancreatic fibrosis (HP:0100732)	2.57575785
32	Rib fusion (HP:0000902)	2.56838867
33	Increased density of long bones (HP:0006392)	2.56572259
34	Hyperglycinemia (HP:0002154)	2.56106172
35	Hypoplastic labia majora (HP:0000059)	2.55856647
36	Hyperglycinuria (HP:0003108)	2.55151374
37	Hypoalbuminemia (HP:0003073)	2.54219033
38	Abnormal albumin level (HP:0012116)	2.54219033
39	Back pain (HP:0003418)	2.53889690
40	Bile duct proliferation (HP:0001408)	2.53694206
41	Abnormal biliary tract physiology (HP:0012439)	2.53694206
42	Abnormal hair laboratory examination (HP:0003328)	2.53349268
43	Attenuation of retinal blood vessels (HP:0007843)	2.52896858
44	Nephronophthisis (HP:0000090)	2.48681441
45	Difficulty climbing stairs (HP:0003551)	2.47220057
46	Advanced eruption of teeth (HP:0006288)	2.46002220
47	Oligodactyly (hands) (HP:0001180)	2.44453006
48	Occipital encephalocele (HP:0002085)	2.42854909
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.38601000
50	Absent/shortened dynein arms (HP:0200106)	2.38601000
51	Autoamputation (HP:0001218)	2.34790501
52	True hermaphroditism (HP:0010459)	2.30299693
53	Bony spicule pigmentary retinopathy (HP:0007737)	2.29351944
54	Abnormality of the labia majora (HP:0012881)	2.26733907
55	Amelogenesis imperfecta (HP:0000705)	2.26569685
56	Cerebral hypomyelination (HP:0006808)	2.22082565
57	Tubular atrophy (HP:0000092)	2.20606136
58	Unilateral renal agenesis (HP:0000122)	2.19259687
59	Pancreatic cysts (HP:0001737)	2.16055243
60	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.15196058
61	Abnormality of the common coagulation pathway (HP:0010990)	2.15149786
62	Asymmetric septal hypertrophy (HP:0001670)	2.14739716
63	Abnormality of the hip-girdle musculature (HP:0001445)	2.14481505
64	Abnormality of the musculature of the pelvis (HP:0001469)	2.14481505
65	Truncal obesity (HP:0001956)	2.13392027
66	Wormian bones (HP:0002645)	2.11245600
67	Abnormality of chloride homeostasis (HP:0011422)	2.06480462
68	Supernumerary spleens (HP:0009799)	2.04763594
69	Broad-based gait (HP:0002136)	2.04320250
70	Type II lissencephaly (HP:0007260)	2.02903317
71	Premature ovarian failure (HP:0008209)	2.01614213
72	Villous atrophy (HP:0011473)	2.00744190
73	Abnormality of small intestinal villus morphology (HP:0011472)	2.00744190
74	Flat capital femoral epiphysis (HP:0003370)	1.99974879
75	Abnormality of the fovea (HP:0000493)	1.99211584
76	Portal hypertension (HP:0001409)	1.98730523
77	Poikilocytosis (HP:0004447)	1.98430325
78	Gingival bleeding (HP:0000225)	1.97132237
79	Tubulointerstitial abnormality (HP:0001969)	1.96697784
80	Hypokinesia (HP:0002375)	1.96370233
81	Congenital primary aphakia (HP:0007707)	1.95572485
82	Absent speech (HP:0001344)	1.94178721
83	Tinnitus (HP:0000360)	1.92431748
84	Polyuria (HP:0000103)	1.92264453
85	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.92260369
86	Hyperkalemia (HP:0002153)	1.89378530
87	Papillary thyroid carcinoma (HP:0002895)	1.88371514
88	Fair hair (HP:0002286)	1.86448052
89	Gait imbalance (HP:0002141)	1.85998330
90	Abnormal sex determination (HP:0012244)	1.85888838
91	Sex reversal (HP:0012245)	1.85888838
92	Brittle hair (HP:0002299)	1.85648853
93	Subcapsular cataract (HP:0000523)	1.85373981
94	Abnormality of the hepatic vasculature (HP:0006707)	1.85259958
95	Medial flaring of the eyebrow (HP:0010747)	1.84839013
96	Male infertility (HP:0003251)	1.82438707
97	Pendular nystagmus (HP:0012043)	1.81818171
98	Tracheomalacia (HP:0002779)	1.81530374
99	Abnormal urine output (HP:0012590)	1.81396409
100	Abnormality of glycine metabolism (HP:0010895)	1.80121047

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	8.34398441
2	TLK1	5.47369609
3	EIF2AK1	5.10330510
4	ZAK	4.50449103
5	STK38L	4.24564249
6	PLK4	3.47453757
7	BRD4	2.95918441
8	MST4	2.75720089
9	PNCK	2.67508175
10	INSRR	2.45300853
11	PHKG2	2.13373542
12	PHKG1	2.13373542
13	CDK12	1.79751833
14	EIF2AK3	1.79739777
15	BMX	1.73011610
16	NEK6	1.71134228
17	BCKDK	1.54690730
18	MET	1.34825677
19	PLK2	1.33479613
20	CAMK1G	1.28641150
21	VRK1	1.16875790
22	NEK1	1.08917756
23	STK38	1.06555459
24	CCNB1	1.04866876
25	PRKD3	1.00898590
26	STK24	0.98421041
27	PDPK1	0.97820053
28	PDK1	0.97484001
29	WNK4	0.93876103
30	PRKCI	0.91710047
31	WNK1	0.88074392
32	NTRK3	0.82082467
33	KDR	0.81649963
34	PRKAA2	0.79246857
35	PIK3CG	0.75739067
36	RPS6KA5	0.72751829
37	TSSK6	0.66540894
38	JAK3	0.63249404
39	PTK2B	0.62419899
40	ADRBK2	0.51155015
41	AKT2	0.48792294
42	PIM1	0.48026316
43	JAK2	0.46722591
44	TTK	0.46152370
45	FLT3	0.46109911
46	EPHA2	0.44374338
47	PIK3CA	0.43854923
48	DAPK2	0.43774691
49	RPS6KB1	0.42250046
50	MAPK14	0.42067711
51	CDK3	0.38061375
52	LRRK2	0.36736509
53	ERN1	0.36697874
54	MST1R	0.35266324
55	MAP3K4	0.32526822
56	STK10	0.32452544
57	CHEK2	0.31735441
58	RPS6KB2	0.31684211
59	PRKAA1	0.31060191
60	CDK7	0.30775989
61	MAPK10	0.29663267
62	WEE1	0.29618796
63	PDK2	0.29233556
64	MAP3K5	0.28564429
65	JAK1	0.27884755
66	BRSK2	0.27563132
67	MTOR	0.27436135
68	CDK2	0.26808004
69	ROCK1	0.26676198
70	TYRO3	0.26336014
71	STK3	0.25856953
72	MAPK1	0.25500898
73	HIPK2	0.25483070
74	CSNK1E	0.24656073
75	CDK6	0.24475507
76	RPS6KA1	0.23540501
77	SGK1	0.22746919
78	MAPK11	0.22649761
79	CAMK1	0.22018217
80	PRKCQ	0.21935992
81	MAP3K8	0.21794899
82	CDK1	0.21446858
83	MAP4K2	0.20650244
84	PKN1	0.20261058
85	GSK3B	0.17525937
86	STK39	0.16177938
87	PRKACB	0.13801217
88	CHEK1	0.13291282
89	RET	0.12420271
90	PRKG2	0.12035900
91	CHUK	0.11963959
92	TRIB3	0.11695630
93	TESK1	0.11454590
94	ITK	0.10996670
95	PASK	0.10704460
96	PINK1	0.10193287
97	CSF1R	0.09887613
98	MATK	0.09177570
99	PKN2	0.08552135
100	MAPK9	0.07867727

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	4.18943410
2	Butanoate metabolism_Homo sapiens_hsa00650	4.14653499
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.42859095
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.22377936
5	Caffeine metabolism_Homo sapiens_hsa00232	2.97859933
6	Base excision repair_Homo sapiens_hsa03410	2.64470298
7	One carbon pool by folate_Homo sapiens_hsa00670	2.53567682
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.38602209
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.33460017
10	Circadian rhythm_Homo sapiens_hsa04710	2.28845881
11	RNA transport_Homo sapiens_hsa03013	2.22662826
12	Arginine biosynthesis_Homo sapiens_hsa00220	2.10041818
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97874507
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.93011977
15	Phenylalanine metabolism_Homo sapiens_hsa00360	1.90510489
16	Olfactory transduction_Homo sapiens_hsa04740	1.81692311
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78003398
18	Mineral absorption_Homo sapiens_hsa04978	1.76347346
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66100578
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.53339433
21	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.51546300
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.46327035
23	Phototransduction_Homo sapiens_hsa04744	1.45718459
24	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.42750706
25	Propanoate metabolism_Homo sapiens_hsa00640	1.39814793
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.35004492
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32565327
28	RNA degradation_Homo sapiens_hsa03018	1.28507670
29	Tyrosine metabolism_Homo sapiens_hsa00350	1.26554778
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24281757
31	Retinol metabolism_Homo sapiens_hsa00830	1.24266104
32	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.24163888
33	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.16589866
34	Taste transduction_Homo sapiens_hsa04742	1.14781985
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.10458325
36	Fatty acid degradation_Homo sapiens_hsa00071	1.07358701
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.05979241
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01900535
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01660232
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99002493
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.94925895
42	Lysine degradation_Homo sapiens_hsa00310	0.92856844
43	Sphingolipid metabolism_Homo sapiens_hsa00600	0.92799909
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88878211
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.84004696
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.83992312
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82126401
48	Glucagon signaling pathway_Homo sapiens_hsa04922	0.80610673
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.79300319
50	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.77529962
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.76683600
52	Sulfur relay system_Homo sapiens_hsa04122	0.76370105
53	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.72391859
54	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71910195
55	Salivary secretion_Homo sapiens_hsa04970	0.70798425
56	Homologous recombination_Homo sapiens_hsa03440	0.70548228
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.70136560
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68929353
59	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.67050897
60	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65712231
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64799561
62	Metabolic pathways_Homo sapiens_hsa01100	0.63205598
63	Insulin resistance_Homo sapiens_hsa04931	0.62223635
64	Basal transcription factors_Homo sapiens_hsa03022	0.61655977
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61243670
66	Amphetamine addiction_Homo sapiens_hsa05031	0.59181276
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57921323
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55289916
69	ABC transporters_Homo sapiens_hsa02010	0.54336904
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.54021414
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.52658289
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52118169
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50119100
74	Legionellosis_Homo sapiens_hsa05134	0.49242192
75	Bile secretion_Homo sapiens_hsa04976	0.48923969
76	Huntingtons disease_Homo sapiens_hsa05016	0.48584839
77	Peroxisome_Homo sapiens_hsa04146	0.47041509
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43142675
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42634861
80	Herpes simplex infection_Homo sapiens_hsa05168	0.40217896
81	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.39832141
82	Long-term depression_Homo sapiens_hsa04730	0.38164940
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38081177
84	Complement and coagulation cascades_Homo sapiens_hsa04610	0.37454136
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.37100184
86	Circadian entrainment_Homo sapiens_hsa04713	0.35571741
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35553500
88	Carbon metabolism_Homo sapiens_hsa01200	0.35498103
89	Insulin secretion_Homo sapiens_hsa04911	0.35265359
90	Alcoholism_Homo sapiens_hsa05034	0.34954756
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34166402
92	Proteasome_Homo sapiens_hsa03050	0.33299222
93	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.33114587
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32266620
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.30569472
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.29297391
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.29145779
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.28799283
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27820935
100	Purine metabolism_Homo sapiens_hsa00230	0.27441512

CALR4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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