CALY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.03480607
2synaptic vesicle exocytosis (GO:0016079)5.57494391
3vocalization behavior (GO:0071625)5.45254815
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39216678
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30588676
6synaptic vesicle maturation (GO:0016188)5.29675005
7regulation of glutamate receptor signaling pathway (GO:1900449)5.16385038
8protein localization to synapse (GO:0035418)5.02137348
9sodium ion export (GO:0071436)4.99794636
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91502096
11neuron cell-cell adhesion (GO:0007158)4.89387744
12regulation of synaptic vesicle exocytosis (GO:2000300)4.87302009
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.86199921
14locomotory exploration behavior (GO:0035641)4.81970763
15glutamate secretion (GO:0014047)4.80465317
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.72040827
17neurotransmitter-gated ion channel clustering (GO:0072578)4.43283149
18neurotransmitter secretion (GO:0007269)4.41378925
19glutamate receptor signaling pathway (GO:0007215)4.36174072
20regulation of synaptic vesicle transport (GO:1902803)4.34650787
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.28886320
22exploration behavior (GO:0035640)4.27262977
23cerebellar granule cell differentiation (GO:0021707)4.26749006
24regulation of neuronal synaptic plasticity (GO:0048168)4.19208765
25neuron-neuron synaptic transmission (GO:0007270)4.19091325
26synaptic transmission, glutamatergic (GO:0035249)4.18466569
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16128388
28positive regulation of dendritic spine development (GO:0060999)4.11389104
29neuronal action potential propagation (GO:0019227)4.11184993
30regulation of voltage-gated calcium channel activity (GO:1901385)4.10979807
31L-amino acid import (GO:0043092)4.09090304
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.02630388
33neuronal ion channel clustering (GO:0045161)4.00800936
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.99241457
35regulation of glutamate secretion (GO:0014048)3.98512710
36potassium ion homeostasis (GO:0055075)3.88292452
37regulation of synapse structural plasticity (GO:0051823)3.82244660
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81350741
39long-term synaptic potentiation (GO:0060291)3.75365088
40neuron recognition (GO:0008038)3.74437828
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.74297875
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.73792622
43positive regulation of membrane potential (GO:0045838)3.73152906
44long-term memory (GO:0007616)3.72999262
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71891275
46positive regulation of synapse maturation (GO:0090129)3.67495722
47response to histamine (GO:0034776)3.66090261
48neurotransmitter transport (GO:0006836)3.65018066
49regulation of postsynaptic membrane potential (GO:0060078)3.63561825
50central nervous system myelination (GO:0022010)3.63362423
51axon ensheathment in central nervous system (GO:0032291)3.63362423
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61820967
53postsynaptic membrane organization (GO:0001941)3.61671802
54neuromuscular process controlling balance (GO:0050885)3.61322854
55amino acid import (GO:0043090)3.60422564
56potassium ion import (GO:0010107)3.59980204
57proline transport (GO:0015824)3.58497687
58neuromuscular process controlling posture (GO:0050884)3.57193102
59cell communication by electrical coupling (GO:0010644)3.55272607
60behavioral defense response (GO:0002209)3.53999291
61behavioral fear response (GO:0001662)3.53999291
62gamma-aminobutyric acid transport (GO:0015812)3.51827065
63synaptic vesicle endocytosis (GO:0048488)3.50021063
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.49858255
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49857809
66presynaptic membrane assembly (GO:0097105)3.49440928
67regulation of synaptic plasticity (GO:0048167)3.49399148
68negative regulation of amino acid transport (GO:0051956)3.46705712
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45617189
70establishment of mitochondrion localization (GO:0051654)3.44328221
71activation of protein kinase A activity (GO:0034199)3.44191263
72regulation of ARF protein signal transduction (GO:0032012)3.42961864
73regulation of vesicle fusion (GO:0031338)3.42410751
74negative regulation of dendrite morphogenesis (GO:0050774)3.41416119
75cell migration in hindbrain (GO:0021535)3.41078053
76dendritic spine organization (GO:0097061)3.41050345
77regulation of neurotransmitter levels (GO:0001505)3.40827798
78dendritic spine morphogenesis (GO:0060997)3.39788109
79cellular sodium ion homeostasis (GO:0006883)3.38869611
80transmission of nerve impulse (GO:0019226)3.38193013
81regulation of dendritic spine development (GO:0060998)3.38037429
82membrane depolarization during action potential (GO:0086010)3.37825342
83layer formation in cerebral cortex (GO:0021819)3.36631853
84neuromuscular synaptic transmission (GO:0007274)3.32711534
85fear response (GO:0042596)3.32676811
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32012534
87axonal fasciculation (GO:0007413)3.31443552
88regulation of neurotransmitter secretion (GO:0046928)3.31332474
89positive regulation of neurotransmitter transport (GO:0051590)3.31175827
90regulation of female receptivity (GO:0045924)3.30589440
91female mating behavior (GO:0060180)3.30583260
92mating behavior (GO:0007617)3.29876670
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27880502
94cellular potassium ion homeostasis (GO:0030007)3.25262374
95presynaptic membrane organization (GO:0097090)3.24656627
96cerebellar Purkinje cell layer development (GO:0021680)3.23697231
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23655662
98behavioral response to cocaine (GO:0048148)3.23368939
99ATP hydrolysis coupled proton transport (GO:0015991)3.20993638
100energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20993638
101establishment of synaptic vesicle localization (GO:0097480)3.20198889
102synaptic vesicle transport (GO:0048489)3.20198889
103synaptic transmission, dopaminergic (GO:0001963)3.18828955
104regulation of dendritic spine morphogenesis (GO:0061001)3.18324356
105positive regulation of neurotransmitter secretion (GO:0001956)3.15625654
106regulation of neurotransmitter transport (GO:0051588)3.15343417
107positive regulation of synaptic transmission (GO:0050806)3.13187220
108cell differentiation in hindbrain (GO:0021533)3.12629461
109membrane depolarization (GO:0051899)3.12507557
110striatum development (GO:0021756)3.11500812
111synaptic transmission (GO:0007268)3.10885645
112cerebellar Purkinje cell differentiation (GO:0021702)3.10004613
113membrane hyperpolarization (GO:0060081)3.09901180
114learning (GO:0007612)3.09346467
115response to auditory stimulus (GO:0010996)3.09022550
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.08982705
117mitochondrion transport along microtubule (GO:0047497)3.08982705
118acidic amino acid transport (GO:0015800)3.07884810
119prepulse inhibition (GO:0060134)3.06836270
120transferrin transport (GO:0033572)3.06275959
121response to dietary excess (GO:0002021)3.05416848
122startle response (GO:0001964)3.05216028
123regulation of synaptic transmission (GO:0050804)3.04763921
124G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04664570
125chemosensory behavior (GO:0007635)3.02650940
126auditory behavior (GO:0031223)3.00891243
127regulation of exocytosis (GO:0017157)3.00703121
128regulation of synaptic transmission, GABAergic (GO:0032228)2.99445516
129regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98390963
130regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.97033604
131regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.97033604
132positive regulation of synapse assembly (GO:0051965)2.96600271
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95407783
134regulation of synapse maturation (GO:0090128)2.94616745
135synapse assembly (GO:0007416)2.93786736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.35142374
2GBX2_23144817_ChIP-Seq_PC3_Human3.89674915
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.30903980
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.21031899
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15598818
6REST_21632747_ChIP-Seq_MESCs_Mouse2.91334083
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79949930
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.78588958
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70628361
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70628361
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.69450724
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.68383989
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.64268905
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61371028
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58458146
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55488482
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.44542036
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.42858716
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40799647
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40182857
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35214549
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.31858194
23DROSHA_22980978_ChIP-Seq_HELA_Human2.22051721
24* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19595394
25TAF15_26573619_Chip-Seq_HEK293_Human2.17037265
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.15259807
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11051447
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08211074
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94716124
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91999604
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91347577
32AR_21572438_ChIP-Seq_LNCaP_Human1.80038737
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78640979
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73597722
35SMAD4_21799915_ChIP-Seq_A2780_Human1.68730066
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66129783
37KDM2B_26808549_Chip-Seq_K562_Human1.61737515
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60916667
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59863930
40P300_19829295_ChIP-Seq_ESCs_Human1.55191676
41ZNF274_21170338_ChIP-Seq_K562_Hela1.53519525
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.52566907
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49546483
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48462724
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.46134009
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44875141
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41146713
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34309905
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34223583
50AR_25329375_ChIP-Seq_VCAP_Human1.33628663
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.32711784
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.32378522
53IGF1R_20145208_ChIP-Seq_DFB_Human1.31832649
54RNF2_27304074_Chip-Seq_NSC_Mouse1.31679096
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30936279
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28898480
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27879930
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27655134
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27268549
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.27116059
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27091979
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.26389364
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.25444299
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19884802
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19822424
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16977296
67FUS_26573619_Chip-Seq_HEK293_Human1.16817194
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.14233232
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13662563
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13205064
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12558032
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12344564
73VDR_22108803_ChIP-Seq_LS180_Human1.09846640
74* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09786506
75STAT3_23295773_ChIP-Seq_U87_Human1.08731504
76AR_19668381_ChIP-Seq_PC3_Human1.06779593
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05538940
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04883024
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04678747
80JUN_21703547_ChIP-Seq_K562_Human1.03035133
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02970176
82OCT4_19829295_ChIP-Seq_ESCs_Human1.01516472
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.01481659
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.00488501
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00035659
86TCF4_23295773_ChIP-Seq_U87_Human0.99990856
87ER_23166858_ChIP-Seq_MCF-7_Human0.99965476
88RUNX2_22187159_ChIP-Seq_PCA_Human0.99696274
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99293863
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97526252
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97028735
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96369740
93LXR_22292898_ChIP-Seq_THP-1_Human0.96322825
94RING1B_27294783_Chip-Seq_NPCs_Mouse0.96057619
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95896582
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94295198
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93675108
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93345623
99DPY_21335234_ChIP-Seq_ESCs_Mouse0.92730128
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91961591
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.91741622
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.91260708
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.90738557
104YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90194949
105SMC4_20622854_ChIP-Seq_HELA_Human0.89358596
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89116949
107KLF4_19829295_ChIP-Seq_ESCs_Human0.87054176
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86403312
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86403312
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85576103
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84849822
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84661010
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84621650
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83808949
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83784799
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83140926
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83122317
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83084104
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82982129
120AHR_22903824_ChIP-Seq_MCF-7_Human0.82113750
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82022451
122CBP_20019798_ChIP-Seq_JUKART_Human0.81976966
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81976966
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.81178258
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.80144164
126* CTCF_27219007_Chip-Seq_Bcells_Human0.79573690
127P68_20966046_ChIP-Seq_HELA_Human0.79433540
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79333310
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77997964
130RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74354155
131* CREB1_26743006_Chip-Seq_LNCaP_Human0.70143039
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67678844
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.67614931
134MYC_19915707_ChIP-ChIP_AK7_Human0.67149241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95398502
2MP0003880_abnormal_central_pattern5.35504507
3* MP0003635_abnormal_synaptic_transmissio4.06400450
4MP0002822_catalepsy3.58095284
5MP0009745_abnormal_behavioral_response3.57134211
6MP0002063_abnormal_learning/memory/cond3.33947027
7MP0002064_seizures3.25685015
8MP0009046_muscle_twitch3.09724380
9MP0001968_abnormal_touch/_nociception3.02802477
10MP0002572_abnormal_emotion/affect_behav2.95197759
11MP0004270_analgesia2.94431200
12MP0005423_abnormal_somatic_nervous2.72535499
13MP0002272_abnormal_nervous_system2.62740197
14MP0001501_abnormal_sleep_pattern2.49401010
15MP0002736_abnormal_nociception_after2.46758481
16MP0003122_maternal_imprinting2.42350173
17MP0001486_abnormal_startle_reflex2.37722489
18MP0001440_abnormal_grooming_behavior2.31017065
19MP0002734_abnormal_mechanical_nocicepti2.30936226
20MP0006276_abnormal_autonomic_nervous2.28315682
21MP0002735_abnormal_chemical_nociception2.22429322
22MP0001529_abnormal_vocalization2.08090477
23MP0003787_abnormal_imprinting2.05064891
24MP0002733_abnormal_thermal_nociception1.96986067
25MP0002067_abnormal_sensory_capabilities1.94289325
26MP0005645_abnormal_hypothalamus_physiol1.92682570
27MP0001970_abnormal_pain_threshold1.91376328
28MP0001984_abnormal_olfaction1.84327745
29MP0005646_abnormal_pituitary_gland1.83963755
30MP0004924_abnormal_behavior1.81800871
31MP0005386_behavior/neurological_phenoty1.81800871
32MP0002557_abnormal_social/conspecific_i1.80644231
33MP0002184_abnormal_innervation1.78032130
34MP0001905_abnormal_dopamine_level1.76473015
35MP0003329_amyloid_beta_deposits1.73235452
36MP0004142_abnormal_muscle_tone1.64397853
37MP0002909_abnormal_adrenal_gland1.57429871
38MP0000778_abnormal_nervous_system1.57242903
39MP0009780_abnormal_chondrocyte_physiolo1.53730648
40* MP0004811_abnormal_neuron_physiology1.52520190
41MP0008569_lethality_at_weaning1.51732778
42MP0001502_abnormal_circadian_rhythm1.51655197
43MP0003879_abnormal_hair_cell1.51578114
44MP0000955_abnormal_spinal_cord1.38820170
45MP0002066_abnormal_motor_capabilities/c1.36905099
46MP0001188_hyperpigmentation1.34182840
47MP0002882_abnormal_neuron_morphology1.33903005
48MP0000751_myopathy1.32241118
49MP0004858_abnormal_nervous_system1.31346044
50MP0000920_abnormal_myelination1.30368268
51MP0002837_dystrophic_cardiac_calcinosis1.17130608
52MP0005551_abnormal_eye_electrophysiolog1.08803924
53MP0003633_abnormal_nervous_system1.07443246
54MP0000013_abnormal_adipose_tissue1.06784967
55MP0002876_abnormal_thyroid_physiology1.06367879
56MP0008872_abnormal_physiological_respon1.05780459
57MP0004885_abnormal_endolymph1.04311733
58MP0002069_abnormal_eating/drinking_beha1.01667352
59MP0003123_paternal_imprinting1.01063555
60MP0002152_abnormal_brain_morphology1.00734315
61MP0010386_abnormal_urinary_bladder0.97809751
62MP0003121_genomic_imprinting0.97721128
63MP0003631_nervous_system_phenotype0.94303985
64MP0002229_neurodegeneration0.92612389
65MP0001485_abnormal_pinna_reflex0.90877353
66MP0000631_abnormal_neuroendocrine_gland0.90541056
67MP0005535_abnormal_body_temperature0.84148562
68MP0008874_decreased_physiological_sensi0.82138167
69MP0004085_abnormal_heartbeat0.80586870
70MP0001963_abnormal_hearing_physiology0.78250391
71MP0001664_abnormal_digestion0.78199341
72MP0004742_abnormal_vestibular_system0.77678206
73MP0002752_abnormal_somatic_nervous0.76892961
74MP0002638_abnormal_pupillary_reflex0.76888627
75MP0000604_amyloidosis0.76473645
76MP0006072_abnormal_retinal_apoptosis0.75723937
77MP0001348_abnormal_lacrimal_gland0.75571406
78MP0008877_abnormal_DNA_methylation0.74262862
79MP0005394_taste/olfaction_phenotype0.73643713
80MP0005499_abnormal_olfactory_system0.73643713
81MP0004145_abnormal_muscle_electrophysio0.72686708
82MP0001986_abnormal_taste_sensitivity0.71735069
83MP0004130_abnormal_muscle_cell0.71122919
84MP0003634_abnormal_glial_cell0.71017056
85MP0003283_abnormal_digestive_organ0.70758810
86MP0002090_abnormal_vision0.70635413
87MP0001177_atelectasis0.66879332
88MP0003075_altered_response_to0.66598257
89MP0003632_abnormal_nervous_system0.63912265
90MP0004215_abnormal_myocardial_fiber0.62792939
91MP0004233_abnormal_muscle_weight0.61857065
92MP0005409_darkened_coat_color0.60909026
93MP0001346_abnormal_lacrimal_gland0.59757235
94MP0003137_abnormal_impulse_conducting0.59384647
95MP0004147_increased_porphyrin_level0.58679892
96MP0003861_abnormal_nervous_system0.58149589
97MP0008961_abnormal_basal_metabolism0.58078280
98MP0004484_altered_response_of0.57279928
99MP0002653_abnormal_ependyma_morphology0.56458518
100MP0010769_abnormal_survival0.55808094
101MP0001943_abnormal_respiration0.54192989
102MP0003690_abnormal_glial_cell0.53488963
103MP0002082_postnatal_lethality0.53372469
104MP0010768_mortality/aging0.52566543
105MP0005448_abnormal_energy_balance0.50640310
106MP0006292_abnormal_olfactory_placode0.50126108
107MP0004043_abnormal_pH_regulation0.50095659
108MP0000026_abnormal_inner_ear0.49555312
109MP0003956_abnormal_body_size0.49306937
110MP0000566_synostosis0.48853497
111MP0003183_abnormal_peptide_metabolism0.48452072
112MP0005623_abnormal_meninges_morphology0.48117165
113MP0005167_abnormal_blood-brain_barrier0.46633727
114MP0010770_preweaning_lethality0.46554222
115MP0001299_abnormal_eye_distance/0.45638034
116MP0004133_heterotaxia0.44299578
117MP0000579_abnormal_nail_morphology0.43905342

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.98829807
2Myokymia (HP:0002411)6.88699393
3Focal seizures (HP:0007359)5.67736454
4Visual hallucinations (HP:0002367)5.42106414
5Atonic seizures (HP:0010819)5.07071323
6Epileptic encephalopathy (HP:0200134)5.05891054
7Febrile seizures (HP:0002373)4.63607821
8Absence seizures (HP:0002121)4.49281017
9Dialeptic seizures (HP:0011146)4.14891818
10Generalized tonic-clonic seizures (HP:0002069)3.92311887
11Progressive cerebellar ataxia (HP:0002073)3.88352925
12Hyperventilation (HP:0002883)3.54534509
13Polyphagia (HP:0002591)3.40807642
14Abnormal eating behavior (HP:0100738)3.39713770
15Cerebral hypomyelination (HP:0006808)3.26363986
16Papilledema (HP:0001085)3.25794126
17Anxiety (HP:0000739)3.24420722
18Akinesia (HP:0002304)3.22671644
19Impaired vibration sensation in the lower limbs (HP:0002166)3.19227094
20Broad-based gait (HP:0002136)3.13044410
21Annular pancreas (HP:0001734)3.08716016
22Depression (HP:0000716)3.07639730
23Failure to thrive in infancy (HP:0001531)3.05053852
24Amblyopia (HP:0000646)3.03907722
25Tetraplegia (HP:0002445)3.03309900
26Intention tremor (HP:0002080)3.01454251
27Limb dystonia (HP:0002451)3.00094928
28Supranuclear gaze palsy (HP:0000605)2.98878918
29Dysdiadochokinesis (HP:0002075)2.92020042
30Abnormal hair whorl (HP:0010721)2.90161731
31Action tremor (HP:0002345)2.89491116
32Gaze-evoked nystagmus (HP:0000640)2.87880245
33Truncal ataxia (HP:0002078)2.80055182
34Dysmetria (HP:0001310)2.78766818
35Mutism (HP:0002300)2.77725527
36Ankle clonus (HP:0011448)2.77207807
37Neuronal loss in central nervous system (HP:0002529)2.75722750
38Poor suck (HP:0002033)2.75163146
39Poor eye contact (HP:0000817)2.74590381
40Obstructive sleep apnea (HP:0002870)2.72007694
41Progressive inability to walk (HP:0002505)2.62867580
42Clonus (HP:0002169)2.60556928
43Abnormality of the lower motor neuron (HP:0002366)2.60537883
44Epileptiform EEG discharges (HP:0011182)2.60121495
45Urinary bladder sphincter dysfunction (HP:0002839)2.57274615
46Gait imbalance (HP:0002141)2.57084710
47Pheochromocytoma (HP:0002666)2.51252788
48Torticollis (HP:0000473)2.49570446
49Drooling (HP:0002307)2.48729252
50Excessive salivation (HP:0003781)2.48729252
51Impaired social interactions (HP:0000735)2.48225588
52Abnormal social behavior (HP:0012433)2.48225588
53Focal dystonia (HP:0004373)2.47261175
54Oligomenorrhea (HP:0000876)2.47062712
55Apathy (HP:0000741)2.46263482
56EEG with generalized epileptiform discharges (HP:0011198)2.43443083
57Postural instability (HP:0002172)2.43382864
58Cerebral inclusion bodies (HP:0100314)2.40270158
59Bradykinesia (HP:0002067)2.38946389
60Morphological abnormality of the pyramidal tract (HP:0002062)2.38225488
61Hypoventilation (HP:0002791)2.38111922
62Insomnia (HP:0100785)2.31475690
63Peripheral hypomyelination (HP:0007182)2.30143456
64Delusions (HP:0000746)2.29251396
65Neuroendocrine neoplasm (HP:0100634)2.28620956
66Hemiparesis (HP:0001269)2.28528489
67Hypsarrhythmia (HP:0002521)2.27275947
68Diminished motivation (HP:0000745)2.26023819
69Abnormality of binocular vision (HP:0011514)2.25012368
70Diplopia (HP:0000651)2.25012368
71Rigidity (HP:0002063)2.25005602
72Fetal akinesia sequence (HP:0001989)2.24458762
73Spastic gait (HP:0002064)2.22403332
74Narrow nasal bridge (HP:0000446)2.22262212
75CNS hypomyelination (HP:0003429)2.21421184
76Congenital primary aphakia (HP:0007707)2.21356662
77Abnormality of the labia minora (HP:0012880)2.20060654
78Craniofacial dystonia (HP:0012179)2.19215062
79Urinary urgency (HP:0000012)2.18398714
80Acute necrotizing encephalopathy (HP:0006965)2.18272890
81Specific learning disability (HP:0001328)2.17468529
82Generalized myoclonic seizures (HP:0002123)2.17200177
83Psychosis (HP:0000709)2.17194884
84Sleep apnea (HP:0010535)2.14510895
85Spastic tetraparesis (HP:0001285)2.14483675
86Medial flaring of the eyebrow (HP:0010747)2.12590307
87Scanning speech (HP:0002168)2.12541906
88Neurofibrillary tangles (HP:0002185)2.11250401
89Choreoathetosis (HP:0001266)2.10274386
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.10047956
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10047956
92Abnormal mitochondria in muscle tissue (HP:0008316)2.09317982
93Nephrogenic diabetes insipidus (HP:0009806)2.08596838
94Impaired smooth pursuit (HP:0007772)2.08071151
95Inability to walk (HP:0002540)2.07682064
96Status epilepticus (HP:0002133)2.07022135
97Agitation (HP:0000713)2.05150782
98Esotropia (HP:0000565)2.05143539
99Amyotrophic lateral sclerosis (HP:0007354)2.02656950
100Menstrual irregularities (HP:0000858)2.00992478
101Genetic anticipation (HP:0003743)2.00642904
102Impaired vibratory sensation (HP:0002495)1.99966594
103Incomplete penetrance (HP:0003829)1.99124782
104Abnormality of the corticospinal tract (HP:0002492)1.98614395
105Stereotypic behavior (HP:0000733)1.98579305
106Megalencephaly (HP:0001355)1.97571073
107Hyperthyroidism (HP:0000836)1.96145135
108Absent speech (HP:0001344)1.94590101
109Spastic tetraplegia (HP:0002510)1.93888689
110Progressive macrocephaly (HP:0004481)1.93668537
111Generalized hypotonia (HP:0001290)1.92280118
112Ventricular fibrillation (HP:0001663)1.92227819
113Rapidly progressive (HP:0003678)1.89859284
114Resting tremor (HP:0002322)1.89853235
115Dysmetric saccades (HP:0000641)1.89068106
116Lower limb muscle weakness (HP:0007340)1.88761183
117Hemiplegia (HP:0002301)1.88333649
118Abnormal EKG (HP:0003115)1.87780234
119Lower limb amyotrophy (HP:0007210)1.84535119
120Retinal dysplasia (HP:0007973)1.84402170
121Spinal canal stenosis (HP:0003416)1.84278248
122Insidious onset (HP:0003587)1.83538232
123Termporal pattern (HP:0011008)1.83538232
124Abnormality of ocular smooth pursuit (HP:0000617)1.83510764
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.83350947
126Absent/shortened dynein arms (HP:0200106)1.83350947
127Diminished movement (HP:0002374)1.80332707
128Increased circulating renin level (HP:0000848)1.71973483
129Hypoplasia of the corpus callosum (HP:0002079)1.71569677
130Unsteady gait (HP:0002317)1.69655147
131Aplasia of the phalanges of the hand (HP:0009802)1.67311091
132Aplasia involving bones of the extremities (HP:0009825)1.67311091
133Aplasia involving bones of the upper limbs (HP:0009823)1.67311091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.79150286
2EPHA44.45222310
3MAP3K93.62244781
4MAP3K123.12949685
5CASK2.94753366
6MAP3K42.91830940
7MAP2K72.62555243
8MARK12.59009242
9MINK12.55741063
10ARAF2.54966888
11DAPK22.17916818
12NTRK22.11266101
13KSR22.01297853
14PLK21.92346345
15MAP2K41.86051114
16PAK61.85188579
17KSR11.73778548
18GRK51.73084785
19DAPK11.68042359
20PRPF4B1.55812975
21TNIK1.52542097
22MAP3K131.50974688
23CDK191.49042859
24RIPK41.48015219
25CDK51.45508068
26MAPK131.39179730
27FES1.38204539
28PNCK1.34440440
29PRKCG1.32903514
30NME11.26549725
31CAMKK11.24620200
32SIK31.18213210
33NTRK11.17238493
34CAMK2A1.16427138
35SIK21.12745312
36PRKD31.12304534
37PTK2B1.07540057
38UHMK11.05074865
39RIPK11.04739099
40RAF11.03435163
41CAMK2B1.00949345
42ALK1.00717822
43CDK180.98865628
44BRAF0.97425247
45PHKG20.94082451
46PHKG10.94082451
47CAMKK20.93881737
48CDK150.92921304
49CDK140.91828809
50STK380.87722953
51MAP3K110.86678851
52OXSR10.86277412
53GRK70.84575335
54CAMK10.84479605
55MAPK120.84358239
56NEK60.84260186
57SGK2230.82991761
58SGK4940.82991761
59PKN10.82356044
60CDK11A0.81197798
61TNK20.81011128
62MAP3K20.79157393
63LIMK10.77663305
64DYRK1A0.75447476
65BMPR20.75189828
66BRSK10.75056787
67PAK30.74886045
68DYRK20.69344136
69TYRO30.68873911
70AKT30.66922259
71FGR0.66424897
72CAMK2G0.65614134
73PRKCH0.64913138
74TAOK10.62559762
75SGK20.61571597
76FER0.61342967
77MAP3K10.61311692
78CCNB10.61062565
79LATS20.60347801
80PRKCE0.59791666
81BCR0.59537945
82SGK10.58782854
83CAMK2D0.58316828
84CSNK1G20.58072008
85LMTK20.57581911
86MAPK100.57440816
87STK110.57194996
88TESK10.56440489
89PINK10.56133214
90ADRBK20.55856994
91MARK20.55586787
92MUSK0.49704609
93MAP2K60.48289539
94ADRBK10.48099009
95DAPK30.46113498
96MAP2K10.45505158
97MAPKAPK50.44420994
98WNK30.42163105
99PDPK10.41883085
100PRKCZ0.41359854
101RPS6KA30.40856016
102PDK10.40128645
103MOS0.39325964
104TSSK60.37493802
105RET0.36369486
106PRKACA0.36346047
107RPS6KA20.35882735
108SGK30.34349586
109FYN0.34220632
110CAMK40.33047524
111FGFR20.32971099
112PRKCB0.32100556
113ROCK20.31917148
114GRK60.31327105
115* PRKCA0.31207096
116CSNK1G30.30639770
117MAPK80.30405634
118PRKG20.29785188
119ERBB20.27505540
120CSNK1E0.26432354
121PRKG10.25166502
122CSNK1D0.24735792

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25553922
2Synaptic vesicle cycle_Homo sapiens_hsa047213.87139324
3GABAergic synapse_Homo sapiens_hsa047272.94200711
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84658115
5Olfactory transduction_Homo sapiens_hsa047402.83379472
6Circadian entrainment_Homo sapiens_hsa047132.73183693
7Collecting duct acid secretion_Homo sapiens_hsa049662.70627289
8Morphine addiction_Homo sapiens_hsa050322.68744746
9Amphetamine addiction_Homo sapiens_hsa050312.57357847
10Long-term potentiation_Homo sapiens_hsa047202.54388201
11Glutamatergic synapse_Homo sapiens_hsa047242.44117160
12* Dopaminergic synapse_Homo sapiens_hsa047282.10609106
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07440705
14Salivary secretion_Homo sapiens_hsa049702.06220239
15Taste transduction_Homo sapiens_hsa047421.95416471
16Insulin secretion_Homo sapiens_hsa049111.90658602
17Cocaine addiction_Homo sapiens_hsa050301.85557122
18Serotonergic synapse_Homo sapiens_hsa047261.84057433
19Cholinergic synapse_Homo sapiens_hsa047251.82750791
20Oxidative phosphorylation_Homo sapiens_hsa001901.76735754
21Gastric acid secretion_Homo sapiens_hsa049711.73903091
22Vibrio cholerae infection_Homo sapiens_hsa051101.71983080
23Renin secretion_Homo sapiens_hsa049241.71399434
24Long-term depression_Homo sapiens_hsa047301.70567125
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66999358
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64415509
27Calcium signaling pathway_Homo sapiens_hsa040201.62052177
28Vitamin B6 metabolism_Homo sapiens_hsa007501.60089257
29Oxytocin signaling pathway_Homo sapiens_hsa049211.55609298
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44604799
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40632107
32Cardiac muscle contraction_Homo sapiens_hsa042601.40428872
33Parkinsons disease_Homo sapiens_hsa050121.37309033
34GnRH signaling pathway_Homo sapiens_hsa049121.32816735
35Gap junction_Homo sapiens_hsa045401.29617868
36Alzheimers disease_Homo sapiens_hsa050101.28740208
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20721991
38cAMP signaling pathway_Homo sapiens_hsa040241.15419668
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11590542
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04359375
41Phototransduction_Homo sapiens_hsa047441.00948674
42Estrogen signaling pathway_Homo sapiens_hsa049151.00028329
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95359856
44Melanogenesis_Homo sapiens_hsa049160.93711879
45Axon guidance_Homo sapiens_hsa043600.92875476
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92562666
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91297129
48Huntingtons disease_Homo sapiens_hsa050160.90721224
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87824661
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.86235828
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84284649
52Glioma_Homo sapiens_hsa052140.82427894
53ErbB signaling pathway_Homo sapiens_hsa040120.77852545
54Type II diabetes mellitus_Homo sapiens_hsa049300.77366477
55Oocyte meiosis_Homo sapiens_hsa041140.74060381
56Rheumatoid arthritis_Homo sapiens_hsa053230.70989695
57Thyroid hormone synthesis_Homo sapiens_hsa049180.66924999
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65967202
59Dilated cardiomyopathy_Homo sapiens_hsa054140.65225110
60Pancreatic secretion_Homo sapiens_hsa049720.63596059
61Type I diabetes mellitus_Homo sapiens_hsa049400.63282614
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63171877
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62258031
64Alcoholism_Homo sapiens_hsa050340.61509471
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.57474139
66Glucagon signaling pathway_Homo sapiens_hsa049220.56211449
67MAPK signaling pathway_Homo sapiens_hsa040100.56113290
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53219105
69Prion diseases_Homo sapiens_hsa050200.51483777
70Choline metabolism in cancer_Homo sapiens_hsa052310.48805939
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46716619
72Ras signaling pathway_Homo sapiens_hsa040140.45337955
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45097755
74Dorso-ventral axis formation_Homo sapiens_hsa043200.44054066
75Arginine and proline metabolism_Homo sapiens_hsa003300.43360676
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42235028
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39913152
78Phagosome_Homo sapiens_hsa041450.37661068
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.37165729
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33452376
81Rap1 signaling pathway_Homo sapiens_hsa040150.32559555
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32151840
83Bile secretion_Homo sapiens_hsa049760.32151744
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31664080
85Ovarian steroidogenesis_Homo sapiens_hsa049130.31299946
86Circadian rhythm_Homo sapiens_hsa047100.30840982
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29683812
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28881618
89VEGF signaling pathway_Homo sapiens_hsa043700.28768507
90Inositol phosphate metabolism_Homo sapiens_hsa005620.27797916
91Arginine biosynthesis_Homo sapiens_hsa002200.27698583
92African trypanosomiasis_Homo sapiens_hsa051430.27053935
93Wnt signaling pathway_Homo sapiens_hsa043100.26525059
94Histidine metabolism_Homo sapiens_hsa003400.26253367
95Mineral absorption_Homo sapiens_hsa049780.25875769
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25443876
97AMPK signaling pathway_Homo sapiens_hsa041520.25363776
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25145826
99Regulation of autophagy_Homo sapiens_hsa041400.25057082
100Insulin signaling pathway_Homo sapiens_hsa049100.24839790
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23990296
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23937963
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.23214443
104Endocytosis_Homo sapiens_hsa041440.22650225
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21918036
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21580508
107Fatty acid biosynthesis_Homo sapiens_hsa000610.20706611
108Tight junction_Homo sapiens_hsa045300.18610112
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.18393667
110Hippo signaling pathway_Homo sapiens_hsa043900.18119362
111Renal cell carcinoma_Homo sapiens_hsa052110.17297832
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16961953
113mTOR signaling pathway_Homo sapiens_hsa041500.16134355

Most similar genes based on co-expression Upload to Enrichr

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