CAMK1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.84890167
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81250312
3synaptic vesicle maturation (GO:0016188)4.79794178
4locomotory exploration behavior (GO:0035641)4.74567226
5glutamate secretion (GO:0014047)4.30085192
6vocalization behavior (GO:0071625)4.26263200
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25522681
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24393246
9synaptic vesicle exocytosis (GO:0016079)4.22097850
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.16510766
11regulation of glutamate receptor signaling pathway (GO:1900449)4.13753259
12neurotransmitter-gated ion channel clustering (GO:0072578)3.89458926
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.89086838
14protein localization to synapse (GO:0035418)3.85283153
15regulation of synaptic vesicle exocytosis (GO:2000300)3.79614047
16cerebellar Purkinje cell differentiation (GO:0021702)3.79139974
17regulation of neuronal synaptic plasticity (GO:0048168)3.70278768
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69376100
19neurotransmitter secretion (GO:0007269)3.67128781
20cerebellar granule cell differentiation (GO:0021707)3.66656265
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65234425
22exploration behavior (GO:0035640)3.57744574
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56711604
24negative regulation of cell killing (GO:0031342)3.56711604
25regulation of synaptic vesicle transport (GO:1902803)3.53297862
26gamma-aminobutyric acid transport (GO:0015812)3.49785590
27synaptic transmission, glutamatergic (GO:0035249)3.42515817
28glutamate receptor signaling pathway (GO:0007215)3.40398164
29dicarboxylic acid biosynthetic process (GO:0043650)3.37370888
30regulation of synapse structural plasticity (GO:0051823)3.36325865
31long-term memory (GO:0007616)3.33013257
32postsynaptic membrane organization (GO:0001941)3.27765972
33amino acid import (GO:0043090)3.24942373
34neuron-neuron synaptic transmission (GO:0007270)3.23701054
35neuronal action potential propagation (GO:0019227)3.22708900
36cellular potassium ion homeostasis (GO:0030007)3.22681587
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21701257
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.16239254
39positive regulation of membrane potential (GO:0045838)3.06723480
40regulation of postsynaptic membrane potential (GO:0060078)3.03656685
41regulation of synaptic plasticity (GO:0048167)3.02537884
42layer formation in cerebral cortex (GO:0021819)3.01662116
43regulation of voltage-gated calcium channel activity (GO:1901385)3.00796258
44membrane depolarization during action potential (GO:0086010)2.99385259
45neuronal ion channel clustering (GO:0045161)2.98370260
46proline transport (GO:0015824)2.98279064
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97721507
48L-phenylalanine catabolic process (GO:0006559)2.97721507
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96530456
50urea metabolic process (GO:0019627)2.96015277
51urea cycle (GO:0000050)2.96015277
52regulation of dendritic spine morphogenesis (GO:0061001)2.95748101
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94357021
54positive regulation of Rap GTPase activity (GO:0032854)2.93305135
55regulation of ARF protein signal transduction (GO:0032012)2.92605139
56cell differentiation in hindbrain (GO:0021533)2.92165762
57regulation of neurotransmitter transport (GO:0051588)2.92108672
58neurotransmitter transport (GO:0006836)2.91685741
59long-term synaptic potentiation (GO:0060291)2.90456056
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90274092
61synaptic vesicle endocytosis (GO:0048488)2.89965022
62behavioral response to cocaine (GO:0048148)2.87487227
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87454153
64sodium ion export (GO:0071436)2.86934395
65dendritic spine morphogenesis (GO:0060997)2.86405303
66aromatic amino acid family catabolic process (GO:0009074)2.85488980
67regulation of synapse maturation (GO:0090128)2.84436471
68high-density lipoprotein particle remodeling (GO:0034375)2.84377576
69regulation of female receptivity (GO:0045924)2.82486312
70regulation of neurotransmitter levels (GO:0001505)2.82462369
71neuron cell-cell adhesion (GO:0007158)2.82376253
72glutamate metabolic process (GO:0006536)2.81629655
73potassium ion import (GO:0010107)2.81218093
74positive regulation of gamma-delta T cell activation (GO:0046645)2.80529439
75regulation of clathrin-mediated endocytosis (GO:2000369)2.78352900
76L-amino acid import (GO:0043092)2.77963940
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77401491
78neuromuscular process controlling balance (GO:0050885)2.76789264
79neuromuscular process controlling posture (GO:0050884)2.76661042
80L-phenylalanine metabolic process (GO:0006558)2.75148572
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75148572
82kynurenine metabolic process (GO:0070189)2.74294864
83negative regulation of dendrite morphogenesis (GO:0050774)2.74004958
84auditory behavior (GO:0031223)2.74000397
85antigen processing and presentation of endogenous antigen (GO:0019883)2.73621300
86response to histamine (GO:0034776)2.73326785
87membrane depolarization (GO:0051899)2.72741832
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71405258
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70535717
90regulation of Rap GTPase activity (GO:0032317)2.70516138
91regulation of vesicle fusion (GO:0031338)2.70428369
92tryptophan catabolic process (GO:0006569)2.69484093
93indole-containing compound catabolic process (GO:0042436)2.69484093
94indolalkylamine catabolic process (GO:0046218)2.69484093
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.68866843
96positive regulation of neurotransmitter transport (GO:0051590)2.68226062
97regulation of exocytosis (GO:0017157)2.68195758
98positive regulation of synapse maturation (GO:0090129)2.67096496
99bile acid biosynthetic process (GO:0006699)2.66000265
100positive regulation of dendritic spine development (GO:0060999)2.64644252
101central nervous system myelination (GO:0022010)2.63854658
102axon ensheathment in central nervous system (GO:0032291)2.63854658
103positive regulation of neurotransmitter secretion (GO:0001956)2.63454991
104activation of protein kinase A activity (GO:0034199)2.62607201
105nitrogen cycle metabolic process (GO:0071941)2.61600400
106regulation of B cell receptor signaling pathway (GO:0050855)2.61214744
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60374473
108behavioral defense response (GO:0002209)2.59812725
109behavioral fear response (GO:0001662)2.59812725
110cell migration in hindbrain (GO:0021535)2.59752128
111regulation of beta-amyloid formation (GO:1902003)2.59051579
112prepulse inhibition (GO:0060134)2.58702127
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58405497
114regulation of dendritic spine development (GO:0060998)2.56283740
115glycine transport (GO:0015816)2.55311232
116gamma-aminobutyric acid signaling pathway (GO:0007214)2.55245748
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.54738622
118reverse cholesterol transport (GO:0043691)2.54561767
119regulation of neurotransmitter secretion (GO:0046928)2.53820311
120alanine transport (GO:0032328)2.52923547
121antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52400822
122neuromuscular synaptic transmission (GO:0007274)2.52257669
123positive regulation of mast cell activation (GO:0033005)2.51785804
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50740863
125female mating behavior (GO:0060180)2.50000130
126synaptic transmission (GO:0007268)2.49467423
127response to auditory stimulus (GO:0010996)2.48931453
128transmission of nerve impulse (GO:0019226)2.47446791
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47375096
130phospholipid efflux (GO:0033700)2.47130683
131cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46698338
132alpha-linolenic acid metabolic process (GO:0036109)2.46244685
133complement activation, alternative pathway (GO:0006957)2.46181383
134chemosensory behavior (GO:0007635)2.44557439
135presynaptic membrane organization (GO:0097090)2.44393516
136positive regulation of synaptic transmission (GO:0050806)2.44219082
137vesicle transport along microtubule (GO:0047496)2.44135883
138regulation of synaptic transmission (GO:0050804)2.43540738
139negative regulation of dendrite development (GO:2000171)2.43214365
140tryptophan metabolic process (GO:0006568)2.42375046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12240051
2GBX2_23144817_ChIP-Seq_PC3_Human2.95249047
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72948796
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41256469
5DROSHA_22980978_ChIP-Seq_HELA_Human2.40488307
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36357382
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.26340917
8REST_21632747_ChIP-Seq_MESCs_Mouse2.21467673
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19615468
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06192151
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.06097795
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05548782
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02509650
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96636196
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96636196
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91579177
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90916572
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86700976
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84727078
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.81849494
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.75935628
22AR_21572438_ChIP-Seq_LNCaP_Human1.75632203
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.72905885
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72330534
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67635812
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.60881270
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58567788
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57740899
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.56459877
30* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56394980
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56040477
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54736141
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51148005
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49665489
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.48178192
36* RUNX_20019798_ChIP-Seq_JUKART_Human1.47976236
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.43847331
38* EED_16625203_ChIP-ChIP_MESCs_Mouse1.40985990
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.34540594
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32617205
41TAF15_26573619_Chip-Seq_HEK293_Human1.32122724
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31111825
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30855962
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30668664
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30211152
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28031228
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22625889
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22414728
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21442599
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.19991867
51P300_19829295_ChIP-Seq_ESCs_Human1.19889185
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17634962
53AR_25329375_ChIP-Seq_VCAP_Human1.17385064
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17209094
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17114518
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15538577
57SCL_19346495_ChIP-Seq_HPC-7_Human1.15381692
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15124814
59STAT3_23295773_ChIP-Seq_U87_Human1.14415961
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12052341
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11144519
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11077246
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10825937
64AR_19668381_ChIP-Seq_PC3_Human1.10008863
65KDM2B_26808549_Chip-Seq_DND41_Human1.09108513
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08756588
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07745878
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07745878
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07699096
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07386024
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06731110
72TP53_16413492_ChIP-PET_HCT116_Human1.06711239
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.05830202
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05606131
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05194364
76BCAT_22108803_ChIP-Seq_LS180_Human1.05184497
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.04302109
78* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03282525
79AHR_22903824_ChIP-Seq_MCF-7_Human1.03013644
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.02867789
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.02019148
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01398659
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01201166
84* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00980191
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00494316
86RXR_22108803_ChIP-Seq_LS180_Human1.00127402
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.99973190
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99916789
89SPI1_23127762_ChIP-Seq_K562_Human0.99852773
90* KDM2B_26808549_Chip-Seq_K562_Human0.99656201
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99502997
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97911067
93* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97030930
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.96338314
95* OCT4_19829295_ChIP-Seq_ESCs_Human0.96012846
96* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96009783
97* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95977880
98* TCF4_23295773_ChIP-Seq_U87_Human0.94970615
99VDR_24787735_ChIP-Seq_THP-1_Human0.94817640
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94372273
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93095489
102* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92633789
103BP1_19119308_ChIP-ChIP_Hs578T_Human0.92490688
104* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91454554
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91319649
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90056118
107* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89806392
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89519661
109* RING1B_27294783_Chip-Seq_ESCs_Mouse0.88421817
110* IRF8_27001747_Chip-Seq_BMDM_Mouse0.88128264
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86654707
112TP53_18474530_ChIP-ChIP_U2OS_Human0.86553587
113* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86417981
114* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86303723
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84593860
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83357368
117* CTCF_27219007_Chip-Seq_Bcells_Human0.83288170
118TCF7_22412390_ChIP-Seq_EML_Mouse0.83169799
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.82861424
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82018227
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81739895
122* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81453123
123* RUNX2_22187159_ChIP-Seq_PCA_Human0.81223423
124* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80649186
125* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80649186
126TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80251775
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80130972
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80111087
129SMC4_20622854_ChIP-Seq_HELA_Human0.79794423
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79639636
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78730634
132* KLF4_19829295_ChIP-Seq_ESCs_Human0.78495135
133* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75045104
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.74822461
135VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74460766
136LXR_22292898_ChIP-Seq_THP-1_Human0.73880860
137KDM2B_26808549_Chip-Seq_REH_Human0.73269901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.17921737
2MP0003880_abnormal_central_pattern3.94225595
3MP0005360_urolithiasis3.59132614
4MP0003635_abnormal_synaptic_transmissio3.53038489
5MP0002822_catalepsy3.49572630
6MP0002139_abnormal_hepatobiliary_system3.48028695
7MP0005085_abnormal_gallbladder_physiolo3.25166148
8MP0004270_analgesia3.09310877
9MP0009745_abnormal_behavioral_response2.96177017
10MP0002063_abnormal_learning/memory/cond2.90215179
11MP0005365_abnormal_bile_salt2.77670302
12MP0002064_seizures2.74657255
13MP0008875_abnormal_xenobiotic_pharmacok2.46526890
14MP0009046_muscle_twitch2.38516300
15MP0001968_abnormal_touch/_nociception2.37127249
16MP0002572_abnormal_emotion/affect_behav2.33912188
17MP0001486_abnormal_startle_reflex2.13352642
18MP0001501_abnormal_sleep_pattern2.08338704
19MP0002272_abnormal_nervous_system1.98825183
20MP0010329_abnormal_lipoprotein_level1.91190975
21MP0003329_amyloid_beta_deposits1.89037448
22MP0003252_abnormal_bile_duct1.88322077
23MP0002734_abnormal_mechanical_nocicepti1.81408365
24MP0005423_abnormal_somatic_nervous1.81346275
25MP0003724_increased_susceptibility_to1.75133846
26MP0002736_abnormal_nociception_after1.74669543
27MP0003075_altered_response_to1.67431317
28MP0002735_abnormal_chemical_nociception1.66653723
29MP0000604_amyloidosis1.66177768
30MP0001440_abnormal_grooming_behavior1.65952622
31MP0009780_abnormal_chondrocyte_physiolo1.60855034
32MP0005551_abnormal_eye_electrophysiolog1.60838952
33MP0003183_abnormal_peptide_metabolism1.59249061
34MP0001348_abnormal_lacrimal_gland1.51692880
35MP0002909_abnormal_adrenal_gland1.48207308
36MP0003690_abnormal_glial_cell1.48032664
37MP0003879_abnormal_hair_cell1.46779057
38MP0003633_abnormal_nervous_system1.45942692
39MP0008569_lethality_at_weaning1.45519453
40MP0002067_abnormal_sensory_capabilities1.39901155
41MP0002090_abnormal_vision1.39804670
42MP0003436_decreased_susceptibility_to1.38503742
43MP0008874_decreased_physiological_sensi1.37795011
44MP0005646_abnormal_pituitary_gland1.36841936
45MP0001666_abnormal_nutrient_absorption1.36802077
46MP0002733_abnormal_thermal_nociception1.35893504
47MP0001970_abnormal_pain_threshold1.35648280
48MP0004924_abnormal_behavior1.34419086
49MP0005386_behavior/neurological_phenoty1.34419086
50MP0004858_abnormal_nervous_system1.29923895
51MP0004811_abnormal_neuron_physiology1.29800820
52MP0004742_abnormal_vestibular_system1.28514199
53MP0004147_increased_porphyrin_level1.26870802
54MP0008872_abnormal_physiological_respon1.24999509
55MP0005671_abnormal_response_to1.24244958
56MP0002557_abnormal_social/conspecific_i1.23893400
57MP0005535_abnormal_body_temperature1.22967615
58MP0003011_delayed_dark_adaptation1.22940432
59MP0005083_abnormal_biliary_tract1.20912858
60MP0003191_abnormal_cellular_cholesterol1.20278407
61MP0001835_abnormal_antigen_presentation1.19107393
62MP0004510_myositis1.18749797
63MP0009840_abnormal_foam_cell1.14909257
64MP0000569_abnormal_digit_pigmentation1.14403265
65MP0001800_abnormal_humoral_immune1.13624369
66MP0001986_abnormal_taste_sensitivity1.11877229
67MP0010234_abnormal_vibrissa_follicle1.11484787
68MP0001984_abnormal_olfaction1.11204150
69MP0001502_abnormal_circadian_rhythm1.10719929
70MP0003631_nervous_system_phenotype1.10345621
71MP0005166_decreased_susceptibility_to1.09598493
72MP0003172_abnormal_lysosome_physiology1.08933242
73MP0002118_abnormal_lipid_homeostasis1.07103046
74MP0005332_abnormal_amino_acid1.06859692
75MP0004885_abnormal_endolymph1.06787918
76MP0005167_abnormal_blood-brain_barrier1.06125530
77MP0003045_fibrosis1.04828626
78MP0005387_immune_system_phenotype1.03683200
79MP0001790_abnormal_immune_system1.03683200
80MP0004019_abnormal_vitamin_homeostasis1.03668164
81MP0002876_abnormal_thyroid_physiology1.03341669
82MP0003868_abnormal_feces_composition1.02990940
83MP0005000_abnormal_immune_tolerance1.02081042
84MP0002066_abnormal_motor_capabilities/c1.01456409
85MP0002653_abnormal_ependyma_morphology1.01160249
86MP0003303_peritoneal_inflammation1.00788274
87MP0002229_neurodegeneration0.99546829
88MP0005584_abnormal_enzyme/coenzyme_acti0.99495014
89MP0000685_abnormal_immune_system0.98440027
90MP0001485_abnormal_pinna_reflex0.96352157
91MP0002184_abnormal_innervation0.94872979
92MP0008961_abnormal_basal_metabolism0.94346378
93MP0000955_abnormal_spinal_cord0.93389685
94MP0001963_abnormal_hearing_physiology0.93261478
95MP0005377_hearing/vestibular/ear_phenot0.92813117
96MP0003878_abnormal_ear_physiology0.92813117
97MP0002882_abnormal_neuron_morphology0.92579587
98MP0002419_abnormal_innate_immunity0.91099226
99MP0002723_abnormal_immune_serum0.90850578
100MP0002420_abnormal_adaptive_immunity0.89398842
101MP0004043_abnormal_pH_regulation0.87167732
102MP0004142_abnormal_muscle_tone0.86905606
103MP0001819_abnormal_immune_cell0.86801412
104MP0001188_hyperpigmentation0.86648848
105MP0002069_abnormal_eating/drinking_beha0.86353434
106MP0002638_abnormal_pupillary_reflex0.84835191
107MP0001177_atelectasis0.84494195
108MP0005025_abnormal_response_to0.83980293
109MP0000778_abnormal_nervous_system0.83537534
110MP0003866_abnormal_defecation0.82863059
111MP0008877_abnormal_DNA_methylation0.79832670
112MP0003195_calcinosis0.78366178
113MP0002452_abnormal_antigen_presenting0.78183125
114MP0006276_abnormal_autonomic_nervous0.77372543
115MP0009278_abnormal_bone_marrow0.77288009
116MP0000609_abnormal_liver_physiology0.76511751
117MP0009764_decreased_sensitivity_to0.75077966
118MP0003122_maternal_imprinting0.74926450
119MP0004130_abnormal_muscle_cell0.72712377
120MP0002928_abnormal_bile_duct0.72300082
121MP0001764_abnormal_homeostasis0.71925215
122MP0003634_abnormal_glial_cell0.71178692
123MP0003763_abnormal_thymus_physiology0.70679200
124MP0000920_abnormal_myelination0.67647551
125MP0005448_abnormal_energy_balance0.66620986
126MP0003632_abnormal_nervous_system0.66034444
127MP0003787_abnormal_imprinting0.64553255
128MP0005310_abnormal_salivary_gland0.64487946
129MP0005319_abnormal_enzyme/_coenzyme0.60459406
130MP0010386_abnormal_urinary_bladder0.60095020
131MP0005464_abnormal_platelet_physiology0.57858359
132MP0005645_abnormal_hypothalamus_physiol0.57361902
133MP0001905_abnormal_dopamine_level0.55054255
134MP0004883_abnormal_blood_vessel0.55000624
135MP0005253_abnormal_eye_physiology0.54816356
136MP0002152_abnormal_brain_morphology0.53274738

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57919820
2Myokymia (HP:0002411)6.07959075
3Focal seizures (HP:0007359)4.76260810
4Visual hallucinations (HP:0002367)4.02252674
5Epileptic encephalopathy (HP:0200134)3.89489190
6Febrile seizures (HP:0002373)3.88144868
7Deep venous thrombosis (HP:0002625)3.86435791
8Progressive cerebellar ataxia (HP:0002073)3.56115890
9Absence seizures (HP:0002121)3.52616164
10Action tremor (HP:0002345)3.51057246
11Generalized tonic-clonic seizures (HP:0002069)3.50404976
12Complement deficiency (HP:0004431)3.40574512
13Hyperventilation (HP:0002883)3.38322350
14Obstructive sleep apnea (HP:0002870)3.33747841
15Status epilepticus (HP:0002133)3.27424839
16Intrahepatic cholestasis (HP:0001406)3.26452484
17Dialeptic seizures (HP:0011146)3.18766271
18Atonic seizures (HP:0010819)3.13540997
19Prolonged partial thromboplastin time (HP:0003645)3.13417587
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11922723
21Dysdiadochokinesis (HP:0002075)3.09117733
22Abnormality of the lower motor neuron (HP:0002366)3.01754144
23Postural instability (HP:0002172)2.98669049
24Hypobetalipoproteinemia (HP:0003563)2.98550908
25Gaze-evoked nystagmus (HP:0000640)2.98454287
26Xanthomatosis (HP:0000991)2.96906113
27Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94837127
28Supranuclear gaze palsy (HP:0000605)2.94583914
29Poor eye contact (HP:0000817)2.92276677
30Abnormal social behavior (HP:0012433)2.91595209
31Impaired social interactions (HP:0000735)2.91595209
32Annular pancreas (HP:0001734)2.90512067
33Impaired vibration sensation in the lower limbs (HP:0002166)2.83539686
34Torticollis (HP:0000473)2.70465840
35Dysmetria (HP:0001310)2.69075587
36Depression (HP:0000716)2.68623144
37Urinary bladder sphincter dysfunction (HP:0002839)2.64376817
38Hyperlipoproteinemia (HP:0010980)2.61055964
39Epidermoid cyst (HP:0200040)2.59247909
40Mutism (HP:0002300)2.56215673
41Focal dystonia (HP:0004373)2.51738877
42Myositis (HP:0100614)2.48572313
43Amyloidosis (HP:0011034)2.47743262
44Systemic lupus erythematosus (HP:0002725)2.46239619
45Neurofibrillary tangles (HP:0002185)2.45549253
46Eczematoid dermatitis (HP:0000976)2.45109518
47Genetic anticipation (HP:0003743)2.44828043
48Abnormality of complement system (HP:0005339)2.44058222
49Optic neuritis (HP:0100653)2.42628883
50Retrobulbar optic neuritis (HP:0100654)2.42628883
51Intention tremor (HP:0002080)2.41943554
52Anxiety (HP:0000739)2.40646251
53Cerebral inclusion bodies (HP:0100314)2.40202826
54Congenital stationary night blindness (HP:0007642)2.40055853
55Hemiparesis (HP:0001269)2.38831345
56Dysmetric saccades (HP:0000641)2.38281746
57Broad-based gait (HP:0002136)2.36851327
58Absent speech (HP:0001344)2.36463678
59Impaired smooth pursuit (HP:0007772)2.33574307
60Joint hemorrhage (HP:0005261)2.33102520
61Impaired vibratory sensation (HP:0002495)2.32987071
62Generalized myoclonic seizures (HP:0002123)2.32709759
63Abnormal eating behavior (HP:0100738)2.30284011
64Limb dystonia (HP:0002451)2.29480601
65Central scotoma (HP:0000603)2.29289496
66Craniofacial dystonia (HP:0012179)2.27746106
67Orchitis (HP:0100796)2.27255409
68Scanning speech (HP:0002168)2.25623346
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25286529
70Stomatitis (HP:0010280)2.22677674
71Papilledema (HP:0001085)2.21737520
72Epileptiform EEG discharges (HP:0011182)2.20840076
73Recurrent gram-negative bacterial infections (HP:0005420)2.19579387
74Truncal ataxia (HP:0002078)2.19397813
75Sleep apnea (HP:0010535)2.19243395
76Protruding tongue (HP:0010808)2.19093810
77Drooling (HP:0002307)2.18218599
78Excessive salivation (HP:0003781)2.18218599
79Amblyopia (HP:0000646)2.15731786
80Recurrent bacterial skin infections (HP:0005406)2.15079594
81Stereotypic behavior (HP:0000733)2.14968002
82Fair hair (HP:0002286)2.12424058
83Bradykinesia (HP:0002067)2.12027410
84Conjugated hyperbilirubinemia (HP:0002908)2.11470359
85Sensorimotor neuropathy (HP:0007141)2.10339384
86Abnormality of the periventricular white matter (HP:0002518)2.09660991
87Memory impairment (HP:0002354)2.09437972
88Hemiplegia (HP:0002301)2.09305588
89Abnormality of the common coagulation pathway (HP:0010990)2.08304358
90Abnormality of ocular smooth pursuit (HP:0000617)2.08105820
91Hypolipoproteinemia (HP:0010981)2.08070258
92Glomerulonephritis (HP:0000099)2.07860728
93EEG with generalized epileptiform discharges (HP:0011198)2.07449268
94Polyphagia (HP:0002591)2.04889184
95Hypercholesterolemia (HP:0003124)2.03996852
96Agitation (HP:0000713)2.03528617
97Spastic tetraparesis (HP:0001285)2.02577692
98Vertigo (HP:0002321)1.98793059
99Fat malabsorption (HP:0002630)1.98758910
100Recurrent abscess formation (HP:0002722)1.97184419
101Diplopia (HP:0000651)1.96590839
102Abnormality of binocular vision (HP:0011514)1.96590839
103Ankle clonus (HP:0011448)1.96436654
104Ventricular fibrillation (HP:0001663)1.96353015
105Generalized hypopigmentation of hair (HP:0011358)1.93872639
106Abnormality of saccadic eye movements (HP:0000570)1.93062981
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.93009971
108Hypsarrhythmia (HP:0002521)1.92805759
109Elevated erythrocyte sedimentation rate (HP:0003565)1.92782237
110Increased IgE level (HP:0003212)1.92572377
111Meningitis (HP:0001287)1.92152078
112Inappropriate behavior (HP:0000719)1.91931942
113Abnormality of the Achilles tendon (HP:0005109)1.91527981
114Acanthocytosis (HP:0001927)1.90818710
115Urinary urgency (HP:0000012)1.90576029
116Spontaneous abortion (HP:0005268)1.90255793
117Cholecystitis (HP:0001082)1.90247532
118Abnormal gallbladder physiology (HP:0012438)1.90247532
119Spastic gait (HP:0002064)1.89984121
120Pigmentary retinal degeneration (HP:0001146)1.89826125
121Lower limb muscle weakness (HP:0007340)1.89479654
122Blue irides (HP:0000635)1.89417612
123Slow saccadic eye movements (HP:0000514)1.87612275
124Absent/shortened dynein arms (HP:0200106)1.87553165
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.87553165
126Global brain atrophy (HP:0002283)1.87045509
127Neuronal loss in central nervous system (HP:0002529)1.86422063
128Rigidity (HP:0002063)1.84832022
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84115747
130Recurrent fungal infections (HP:0002841)1.83980196
131Neonatal onset (HP:0003623)1.83955348
132Clonus (HP:0002169)1.83835379
133Lower limb hyperreflexia (HP:0002395)1.83325566
134Tetraplegia (HP:0002445)1.82203509
135Encephalitis (HP:0002383)1.77142490
136Akinesia (HP:0002304)1.76927088
137Abnormality of the fingertips (HP:0001211)1.76724103
138Widely spaced teeth (HP:0000687)1.76167716
139Stomach cancer (HP:0012126)1.75778015
140Apathy (HP:0000741)1.75722269
141Abnormality of the corticospinal tract (HP:0002492)1.75498532
142Inability to walk (HP:0002540)1.75173264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.02223640
2NTRK34.13992491
3MAP3K93.60334536
4RIPK43.23055798
5DAPK22.89909473
6MAP3K42.52291976
7KSR22.36632172
8MINK12.34055847
9MAP2K42.24962917
10MAP3K132.09047913
11PAK62.08141239
12MAP2K72.06254986
13MAP3K122.01167084
14SIK21.76296572
15FES1.70325490
16DAPK11.70321710
17MARK11.70238789
18MAP4K11.66049369
19STK381.63677443
20NTRK11.54092961
21PRKD31.50587836
22INSRR1.47802516
23KSR11.46694346
24NTRK21.41219139
25CDK51.39165132
26* CAMKK11.38073351
27MAP3K21.28690762
28PRPF4B1.23683481
29BMPR21.19546543
30ARAF1.15499468
31PRKCG1.13383746
32SGK31.09992620
33GRK51.08858129
34SGK21.08597268
35PDK11.07638045
36TAOK11.05065211
37BLK1.03263311
38MAP3K110.96492978
39PRKCH0.94102072
40CAMKK20.93251108
41RAF10.92814253
42PLK20.92697490
43TNK20.91016991
44LMTK20.90624667
45CAMK10.90406558
46MAP3K70.90014150
47CAMK1G0.89531311
48RIPK10.88133015
49PDPK10.87534342
50CAMK2A0.87188541
51STK110.86985310
52SGK4940.86228460
53SGK2230.86228460
54CASK0.85721106
55RET0.84688302
56WNK10.83878020
57ACVR1B0.83763256
58TAOK30.78429402
59SGK10.78352948
60MAP2K60.75932076
61MAP3K10.75601985
62PINK10.75549437
63PRKCZ0.74821026
64OXSR10.73226499
65PTK2B0.72770150
66CSK0.71941867
67TXK0.70443741
68MAPK130.67104732
69CAMK40.66814394
70JAK10.66221632
71TYK20.64731318
72SIK30.64455864
73IRAK40.64451993
74BTK0.64356577
75FGR0.63783389
76CDK190.62568992
77TNIK0.61855185
78GRK60.61744897
79TYRO30.61003482
80MAP3K140.60344439
81CAMK2B0.58957417
82MAPK120.58239954
83JAK20.57295974
84MAP3K60.56426119
85ITK0.55813013
86PRKCQ0.55672272
87CSNK1G20.54328260
88HIPK20.54209856
89FYN0.53283137
90SYK0.53026815
91IRAK20.52639549
92FRK0.51286997
93NEK60.50741440
94CSF1R0.50493088
95* RPS6KA30.50473976
96DYRK1A0.49811328
97CDK180.49501845
98PNCK0.48524304
99CDK150.48494688
100LYN0.48263956
101PKN10.48118951
102KIT0.47950807
103MAP2K10.47447388
104ALK0.47303894
105LCK0.47000250
106ZAP700.45143604
107PRKD20.45011655
108SIK10.44665527
109IKBKE0.44324128
110UHMK10.43736763
111PAK30.42937362
112GRK10.42561156
113MAPK70.41828873
114CDK140.40591487
115HCK0.39261855
116LATS20.38557123
117CDK11A0.37850793
118PRKACG0.37742145
119ADRBK10.37582871
120MAPK100.37486944
121CAMK2G0.36652025
122PRKCA0.36489810
123PRKCB0.36347231
124CAMK1D0.36032495
125AKT30.35657844
126MAP3K50.35196548
127MARK20.33292344

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.92203070
2Nicotine addiction_Homo sapiens_hsa050332.55392659
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47154596
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.43591535
5Arginine biosynthesis_Homo sapiens_hsa002202.30917334
6Synaptic vesicle cycle_Homo sapiens_hsa047212.30372770
7Olfactory transduction_Homo sapiens_hsa047402.17922575
8Long-term potentiation_Homo sapiens_hsa047202.05542406
9GABAergic synapse_Homo sapiens_hsa047271.96120163
10Glutamatergic synapse_Homo sapiens_hsa047241.95232876
11Circadian entrainment_Homo sapiens_hsa047131.94347561
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84975797
13Amphetamine addiction_Homo sapiens_hsa050311.83306925
14Morphine addiction_Homo sapiens_hsa050321.75078698
15Salivary secretion_Homo sapiens_hsa049701.72359934
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63544002
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54636329
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52205805
19Phototransduction_Homo sapiens_hsa047441.52037164
20Bile secretion_Homo sapiens_hsa049761.48448259
21Dopaminergic synapse_Homo sapiens_hsa047281.47185730
22* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42276743
23Cholinergic synapse_Homo sapiens_hsa047251.39617510
24Gastric acid secretion_Homo sapiens_hsa049711.39157333
25Insulin secretion_Homo sapiens_hsa049111.36761405
26Complement and coagulation cascades_Homo sapiens_hsa046101.33653775
27B cell receptor signaling pathway_Homo sapiens_hsa046621.33610676
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29273194
29Staphylococcus aureus infection_Homo sapiens_hsa051501.25049877
30Renin secretion_Homo sapiens_hsa049241.22487083
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19212002
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16173556
33Calcium signaling pathway_Homo sapiens_hsa040201.11755805
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11273457
35Osteoclast differentiation_Homo sapiens_hsa043801.10979995
36Allograft rejection_Homo sapiens_hsa053301.10903275
37Graft-versus-host disease_Homo sapiens_hsa053321.10591527
38* Oxytocin signaling pathway_Homo sapiens_hsa049211.09374229
39Cocaine addiction_Homo sapiens_hsa050301.07061756
40Leishmaniasis_Homo sapiens_hsa051401.06962597
41Tuberculosis_Homo sapiens_hsa051521.06188318
42Long-term depression_Homo sapiens_hsa047301.05655224
43Autoimmune thyroid disease_Homo sapiens_hsa053201.04062599
44GnRH signaling pathway_Homo sapiens_hsa049121.03982937
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02631946
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.01290845
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00433586
48Type I diabetes mellitus_Homo sapiens_hsa049400.99689551
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98542921
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97878764
51Type II diabetes mellitus_Homo sapiens_hsa049300.96548990
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95235210
53Tryptophan metabolism_Homo sapiens_hsa003800.94448901
54Asthma_Homo sapiens_hsa053100.93565607
55cAMP signaling pathway_Homo sapiens_hsa040240.90770311
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90672095
57Serotonergic synapse_Homo sapiens_hsa047260.89707736
58T cell receptor signaling pathway_Homo sapiens_hsa046600.89128629
59Taste transduction_Homo sapiens_hsa047420.87472275
60Butanoate metabolism_Homo sapiens_hsa006500.85113151
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84817968
62Glioma_Homo sapiens_hsa052140.83452589
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81385861
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79684852
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78245439
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77286087
67African trypanosomiasis_Homo sapiens_hsa051430.76122638
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72958561
69Ras signaling pathway_Homo sapiens_hsa040140.72887366
70Platelet activation_Homo sapiens_hsa046110.72285782
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.71929081
72PPAR signaling pathway_Homo sapiens_hsa033200.70092045
73Pancreatic secretion_Homo sapiens_hsa049720.68825415
74Gap junction_Homo sapiens_hsa045400.68589958
75Estrogen signaling pathway_Homo sapiens_hsa049150.67575687
76ErbB signaling pathway_Homo sapiens_hsa040120.67075298
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66755698
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66494021
79Primary immunodeficiency_Homo sapiens_hsa053400.65946170
80Caffeine metabolism_Homo sapiens_hsa002320.65831777
81Rap1 signaling pathway_Homo sapiens_hsa040150.65635217
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64609923
83ABC transporters_Homo sapiens_hsa020100.64290541
84Dorso-ventral axis formation_Homo sapiens_hsa043200.64048298
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63114314
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61918514
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61606780
88Prion diseases_Homo sapiens_hsa050200.58411775
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57753835
90Endocytosis_Homo sapiens_hsa041440.56570695
91Starch and sucrose metabolism_Homo sapiens_hsa005000.55172095
92Thyroid hormone synthesis_Homo sapiens_hsa049180.55068744
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54774463
94Fatty acid degradation_Homo sapiens_hsa000710.54536273
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.54193312
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53568157
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.52015176
98Retinol metabolism_Homo sapiens_hsa008300.51828591
99Prolactin signaling pathway_Homo sapiens_hsa049170.50957717
100Chemical carcinogenesis_Homo sapiens_hsa052040.50428287
101Histidine metabolism_Homo sapiens_hsa003400.49781477
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.49724443
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49368291
104Choline metabolism in cancer_Homo sapiens_hsa052310.48701895
105Glycerolipid metabolism_Homo sapiens_hsa005610.48417362
106Phagosome_Homo sapiens_hsa041450.48296908
107Acute myeloid leukemia_Homo sapiens_hsa052210.47157746
108Collecting duct acid secretion_Homo sapiens_hsa049660.47108488
109Circadian rhythm_Homo sapiens_hsa047100.46756873
110Renal cell carcinoma_Homo sapiens_hsa052110.46482710
111Glucagon signaling pathway_Homo sapiens_hsa049220.46453822
112Rheumatoid arthritis_Homo sapiens_hsa053230.44662154
113Melanogenesis_Homo sapiens_hsa049160.44357796
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44336455
115VEGF signaling pathway_Homo sapiens_hsa043700.44105999
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.43330809
117Toxoplasmosis_Homo sapiens_hsa051450.43072746
118Fat digestion and absorption_Homo sapiens_hsa049750.42280714
119beta-Alanine metabolism_Homo sapiens_hsa004100.42175695
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41993422
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41971341
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.41790054
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41440243
124Inositol phosphate metabolism_Homo sapiens_hsa005620.41194601
125Peroxisome_Homo sapiens_hsa041460.39301708
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37798214
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36909079
128Phenylalanine metabolism_Homo sapiens_hsa003600.36871846
129Chemokine signaling pathway_Homo sapiens_hsa040620.36588847
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36541305
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36239711
132Fatty acid metabolism_Homo sapiens_hsa012120.36108549
133Non-small cell lung cancer_Homo sapiens_hsa052230.34541733
134Axon guidance_Homo sapiens_hsa043600.33510422
135mTOR signaling pathway_Homo sapiens_hsa041500.33115704
136MAPK signaling pathway_Homo sapiens_hsa040100.33002546

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