CAMK2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.27007946
2keratinocyte development (GO:0003334)6.28616909
3phospholipid homeostasis (GO:0055091)5.45877301
4platelet dense granule organization (GO:0060155)5.21972583
5L-serine transport (GO:0015825)4.62359535
6phospholipid efflux (GO:0033700)4.53686305
7protein localization to cilium (GO:0061512)4.24166973
8reverse cholesterol transport (GO:0043691)4.23668586
9* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.99875278
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.91161763
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83085514
12* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.82156453
13positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.77738708
14serine transport (GO:0032329)3.75632266
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.74968135
16* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.66662217
17plasma lipoprotein particle assembly (GO:0034377)3.66548142
18intraciliary transport (GO:0042073)3.62916896
19peptidyl-cysteine modification (GO:0018198)3.62365926
20response to lipoprotein particle (GO:0055094)3.61150461
21neural tube formation (GO:0001841)3.46296479
22synaptic vesicle maturation (GO:0016188)3.45027226
23regulation of cardioblast differentiation (GO:0051890)3.41460147
24vocalization behavior (GO:0071625)3.41261573
25synaptic vesicle exocytosis (GO:0016079)3.40241241
26cell communication by electrical coupling (GO:0010644)3.38883582
27cellular potassium ion homeostasis (GO:0030007)3.30072415
28anatomical structure regression (GO:0060033)3.29046944
29glutamate secretion (GO:0014047)3.28770483
30regulation of synaptic vesicle exocytosis (GO:2000300)3.27705391
31sodium ion export (GO:0071436)3.26436239
32regulation of transforming growth factor beta2 production (GO:0032909)3.24818087
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19369008
34hindbrain development (GO:0030902)3.18798477
35positive regulation of potassium ion transmembrane transport (GO:1901381)3.18502737
36negative regulation of activin receptor signaling pathway (GO:0032926)3.17725497
37otic vesicle formation (GO:0030916)3.16841888
38protein-lipid complex assembly (GO:0065005)3.16600194
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16436861
40regulation of axon extension involved in axon guidance (GO:0048841)3.14823198
41positive regulation of glycoprotein metabolic process (GO:1903020)3.14321119
42plasma membrane repair (GO:0001778)3.13068775
43nephron tubule morphogenesis (GO:0072078)3.12564171
44nephron epithelium morphogenesis (GO:0072088)3.12564171
45locomotory exploration behavior (GO:0035641)3.10291306
46cerebellar Purkinje cell differentiation (GO:0021702)3.09793687
47* regulation of cell communication by electrical coupling (GO:0010649)3.09160133
48cell communication involved in cardiac conduction (GO:0086065)3.08722512
49positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.07820327
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06584838
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.05429631
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.02716360
53neuron cell-cell adhesion (GO:0007158)3.01902643
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01849677
55renal tubule morphogenesis (GO:0061333)3.01547378
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00139940
57regulation of glucokinase activity (GO:0033131)2.97677174
58regulation of hexokinase activity (GO:1903299)2.97677174
59regulation of voltage-gated calcium channel activity (GO:1901385)2.96686089
60* regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.95192543
61lactate metabolic process (GO:0006089)2.93666107
62regulation of membrane repolarization (GO:0060306)2.93558779
63regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89044867
64membrane depolarization during action potential (GO:0086010)2.89011649
65cellular response to sterol (GO:0036315)2.88402954
66negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.87799066
67positive regulation of glycoprotein biosynthetic process (GO:0010560)2.87690810
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87300812
69pericardium development (GO:0060039)2.84216021
70positive regulation of protein autophosphorylation (GO:0031954)2.83682856
71cellular ketone body metabolic process (GO:0046950)2.83354846
72cellular response to cholesterol (GO:0071397)2.82317186
73protein localization to synapse (GO:0035418)2.79717006
74cardiac myofibril assembly (GO:0055003)2.78183846
75cholesterol efflux (GO:0033344)2.77909631
76potassium ion import (GO:0010107)2.76741373
77negative regulation of hormone biosynthetic process (GO:0032353)2.76196989
78regulation of synaptic vesicle transport (GO:1902803)2.76130631
79retinal cone cell development (GO:0046549)2.75742207
80striated muscle hypertrophy (GO:0014897)2.75370268
81embryonic digestive tract morphogenesis (GO:0048557)2.74926902
82regulation of axon guidance (GO:1902667)2.74821696
83response to redox state (GO:0051775)2.74702236
84somite rostral/caudal axis specification (GO:0032525)2.74600038
85auditory receptor cell differentiation (GO:0042491)2.74129450
86cardiac right ventricle morphogenesis (GO:0003215)2.74077295
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74060000
88* regulation of calcium ion transmembrane transport (GO:1903169)2.71580722
89* regulation of calcium ion transmembrane transporter activity (GO:1901019)2.71580722
90positive regulation of actin filament depolymerization (GO:0030836)2.71064230
91* regulation of relaxation of muscle (GO:1901077)2.71042152
92regulation of glutamate receptor signaling pathway (GO:1900449)2.69979267
93regulation of acyl-CoA biosynthetic process (GO:0050812)2.69913636
94regulation of potassium ion transmembrane transporter activity (GO:1901016)2.69525387
95proline transport (GO:0015824)2.68691755
96cardiac muscle contraction (GO:0060048)2.68514104
97anterior/posterior axis specification, embryo (GO:0008595)2.68247315
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68082165
99presynaptic membrane assembly (GO:0097105)2.67925942
100negative regulation of potassium ion transmembrane transport (GO:1901380)2.66436372
101positive regulation of cation channel activity (GO:2001259)2.66101845
102activation of protein kinase A activity (GO:0034199)2.65624999
103cilium morphogenesis (GO:0060271)2.65399353
104regulation of sulfur metabolic process (GO:0042762)2.64687725
105neurotransmitter secretion (GO:0007269)2.62779392
106cardiac muscle adaptation (GO:0014887)2.61400089
107cardiac muscle hypertrophy in response to stress (GO:0014898)2.61400089
108muscle hypertrophy in response to stress (GO:0003299)2.61400089
109regulation of actin filament-based movement (GO:1903115)2.60665822
110regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.60413873
111membrane repolarization (GO:0086009)2.58872220
112positive regulation of potassium ion transport (GO:0043268)2.58546728
113female gonad development (GO:0008585)2.57805497
114negative regulation of dendrite morphogenesis (GO:0050774)2.55817176
115zinc ion transport (GO:0006829)2.55423018
116limb bud formation (GO:0060174)2.54847965
117sarcoplasmic reticulum calcium ion transport (GO:0070296)2.54595018
118regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54581483
119detection of calcium ion (GO:0005513)2.54490801
120* relaxation of cardiac muscle (GO:0055119)2.53386564
121membrane assembly (GO:0071709)2.53150419
122regulation of potassium ion transmembrane transport (GO:1901379)2.52992939
123Golgi to endosome transport (GO:0006895)2.52955175
124* cardiac conduction (GO:0061337)2.52259612
125rhodopsin mediated signaling pathway (GO:0016056)2.51745573
126positive regulation of cardiac muscle tissue growth (GO:0055023)2.51038573
127regulation of cardiac muscle cell contraction (GO:0086004)2.50396536
128neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50026722
129negative regulation of translation, ncRNA-mediated (GO:0040033)2.49946064
130regulation of translation, ncRNA-mediated (GO:0045974)2.49946064
131negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49946064
132* positive regulation of muscle hypertrophy (GO:0014742)2.49691345
133* positive regulation of cardiac muscle hypertrophy (GO:0010613)2.49691345
134regulation of synapse structural plasticity (GO:0051823)2.49674402
135signal transduction involved in regulation of gene expression (GO:0023019)2.49172138
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.48274460
137positive regulation of cardiac muscle cell proliferation (GO:0060045)2.47695011
138sarcomere organization (GO:0045214)2.47582634
139regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.46700471
140preassembly of GPI anchor in ER membrane (GO:0016254)2.46524504
141regulation of neurotransmitter secretion (GO:0046928)2.46368387
142regulation of sarcomere organization (GO:0060297)2.45948053
143ketone body metabolic process (GO:1902224)2.45806668
144cardiac muscle cell development (GO:0055013)2.43557369
145intracellular lipid transport (GO:0032365)2.43013124
146* regulation of cation channel activity (GO:2001257)2.42520617
147layer formation in cerebral cortex (GO:0021819)2.41068092
148* actin-mediated cell contraction (GO:0070252)2.40212656
149* regulation of cardiac muscle contraction (GO:0055117)2.39840550
150high-density lipoprotein particle remodeling (GO:0034375)2.39673791
151regulation of protein glycosylation (GO:0060049)2.38870578
152response to BMP (GO:0071772)2.38458887
153cellular response to BMP stimulus (GO:0071773)2.38458887
154regulation of type B pancreatic cell apoptotic process (GO:2000674)2.38408396
155membrane repolarization during action potential (GO:0086011)2.38358360
156potassium ion homeostasis (GO:0055075)2.38230833
157DNA integration (GO:0015074)2.38028352
158histamine secretion (GO:0001821)2.37165377
159C-terminal protein lipidation (GO:0006501)2.36626165
160establishment of nucleus localization (GO:0040023)2.36519662
161positive regulation of ion transmembrane transporter activity (GO:0032414)2.34817661
162branched-chain amino acid catabolic process (GO:0009083)2.34734811
163* regulation of striated muscle contraction (GO:0006942)2.34455225
164regulation of excitatory postsynaptic membrane potential (GO:0060079)2.33779670
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.33541635
166regulation of postsynaptic membrane potential (GO:0060078)2.33522858
167vesicle transport along microtubule (GO:0047496)2.33405099
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32991318
169embryonic epithelial tube formation (GO:0001838)2.32421818
170glutamate receptor signaling pathway (GO:0007215)2.32276848
171regulation of cytokine secretion involved in immune response (GO:0002739)2.31948812
172myofibril assembly (GO:0030239)2.31881852
173phosphatidylcholine biosynthetic process (GO:0006656)2.31172065
174amino acid salvage (GO:0043102)2.31133630
175L-methionine salvage (GO:0071267)2.31133630
176L-methionine biosynthetic process (GO:0071265)2.31133630
177axoneme assembly (GO:0035082)2.30876347
178membrane depolarization (GO:0051899)2.29616551
179synaptic vesicle endocytosis (GO:0048488)2.29385814
180ionotropic glutamate receptor signaling pathway (GO:0035235)2.29139272
181postsynaptic membrane organization (GO:0001941)2.28639953
182G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.27755516
183cardiac muscle hypertrophy (GO:0003300)2.26947263
184exploration behavior (GO:0035640)2.26543346
185regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24242889
186negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.23608549
187negative regulation of calcium ion transmembrane transport (GO:1903170)2.23608549
188positive regulation of cardiac muscle cell differentiation (GO:2000727)2.22990912
189ventricular cardiac muscle cell action potential (GO:0086005)2.21262334
190photoreceptor cell development (GO:0042461)2.20958526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.00341853
2GBX2_23144817_ChIP-Seq_PC3_Human3.07221043
3* SMAD_19615063_ChIP-ChIP_OVARY_Human2.59932130
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39032314
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32012102
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17640566
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09779701
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05310310
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04192453
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04192453
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.03336639
12FUS_26573619_Chip-Seq_HEK293_Human2.02908587
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99130920
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95671378
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91539341
16DROSHA_22980978_ChIP-Seq_HELA_Human1.91001946
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.89597416
18AR_21572438_ChIP-Seq_LNCaP_Human1.86106151
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84152509
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.83686659
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80095246
22SMAD4_21799915_ChIP-Seq_A2780_Human1.77194750
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.76542319
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.75621154
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73178777
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.70974375
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.69597376
28* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67226195
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66375327
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64561950
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64452919
32EWS_26573619_Chip-Seq_HEK293_Human1.63067942
33TAF15_26573619_Chip-Seq_HEK293_Human1.62915390
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62842298
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61739690
36VDR_22108803_ChIP-Seq_LS180_Human1.60404833
37* NANOG_18555785_Chip-Seq_ESCs_Mouse1.57549860
38SMAD3_21741376_ChIP-Seq_HESCs_Human1.55791190
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.54769078
40* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53641117
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53431808
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52532384
43AHR_22903824_ChIP-Seq_MCF-7_Human1.51781467
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51053279
45* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49430703
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46783954
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46251996
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.45752592
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44815951
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44476740
51* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44369644
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.43329364
53IGF1R_20145208_ChIP-Seq_DFB_Human1.42893633
54* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42333984
55* E2F1_18555785_Chip-Seq_ESCs_Mouse1.42059580
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.41080841
57* P300_19829295_ChIP-Seq_ESCs_Human1.39662573
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.37677701
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37647540
60* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37525951
61* P53_22387025_ChIP-Seq_ESCs_Mouse1.37178390
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35704810
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.35658844
64REST_21632747_ChIP-Seq_MESCs_Mouse1.33567228
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33534430
66* CDX2_22108803_ChIP-Seq_LS180_Human1.32673344
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.32229129
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.31516000
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31411737
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.31328367
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30602374
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30324933
73CBP_20019798_ChIP-Seq_JUKART_Human1.30324933
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30300423
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29731780
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29598246
77TP53_18474530_ChIP-ChIP_U2OS_Human1.29332683
78* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29021188
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28840328
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.27262178
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.26408927
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26270047
83NANOG_19829295_ChIP-Seq_ESCs_Human1.26066218
84SOX2_19829295_ChIP-Seq_ESCs_Human1.26066218
85* TCF4_22108803_ChIP-Seq_LS180_Human1.25710034
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25094502
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.24602965
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24241287
89* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22970816
90STAT3_23295773_ChIP-Seq_U87_Human1.22001475
91* TP53_16413492_ChIP-PET_HCT116_Human1.21955090
92BCAT_22108803_ChIP-Seq_LS180_Human1.21696164
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20998774
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20009038
95* P300_18555785_Chip-Seq_ESCs_Mouse1.19827255
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19119674
97* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18866537
98BRD4_25478319_ChIP-Seq_HGPS_Human1.18494560
99* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18303708
100AR_25329375_ChIP-Seq_VCAP_Human1.18301888
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.16379004
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15477443
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15245936
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15211240
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.14834548
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.14114313
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.13691819
108* CJUN_26792858_Chip-Seq_BT549_Human1.13056674
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12670051
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11911052
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11874047
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11119625
113* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10634283
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10600694
115* AR_19668381_ChIP-Seq_PC3_Human1.09240049
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08424561
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08081385
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08081385
119NMYC_18555785_Chip-Seq_ESCs_Mouse1.07977243
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07826515
121ELK1_19687146_ChIP-ChIP_HELA_Human1.07770741
122ZNF274_21170338_ChIP-Seq_K562_Hela1.07422518
123* TCF4_23295773_ChIP-Seq_U87_Human1.06964260
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.05933513
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04537526
126* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04435047
127* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04271147
128* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03848739
129WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03059784
130* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02243223
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00570548
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00418467
133* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00396726
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.99802685
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99674538
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99020396
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98649294
138* RXR_22108803_ChIP-Seq_LS180_Human0.98436743
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.97430948
140ER_23166858_ChIP-Seq_MCF-7_Human0.97350525
141* RUNX2_22187159_ChIP-Seq_PCA_Human0.95669159
142* RUNX_20019798_ChIP-Seq_JUKART_Human0.94365152
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.92324531
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92280388
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.90756021
146* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90426583
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88697133
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88440426
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87601339
150* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86240484
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85928081
152* VDR_24787735_ChIP-Seq_THP-1_Human0.85538662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.05018000
2MP0006054_spinal_hemorrhage4.24991189
3MP0000751_myopathy2.93338851
4MP0004859_abnormal_synaptic_plasticity2.92340737
5MP0001968_abnormal_touch/_nociception2.82025728
6MP0003191_abnormal_cellular_cholesterol2.81453291
7MP0001984_abnormal_olfaction2.55365360
8MP0000372_irregular_coat_pigmentation2.53980795
9MP0004084_abnormal_cardiac_muscle2.47463342
10MP0009046_muscle_twitch2.36640514
11MP0003635_abnormal_synaptic_transmissio2.32580815
12MP0004270_analgesia2.31575025
13MP0003646_muscle_fatigue2.31296144
14MP0002735_abnormal_chemical_nociception2.30186953
15MP0004215_abnormal_myocardial_fiber2.29952279
16MP0002736_abnormal_nociception_after2.28043064
17MP0005551_abnormal_eye_electrophysiolog2.23854364
18MP0003880_abnormal_central_pattern2.21771877
19MP0002837_dystrophic_cardiac_calcinosis2.20752221
20MP0002734_abnormal_mechanical_nocicepti2.17477114
21MP0004510_myositis2.12339415
22MP0000516_abnormal_urinary_system2.08055662
23MP0005367_renal/urinary_system_phenotyp2.08055662
24MP0008995_early_reproductive_senescence1.98733281
25MP0000569_abnormal_digit_pigmentation1.92710091
26MP0004036_abnormal_muscle_relaxation1.91109540
27MP0000749_muscle_degeneration1.88893100
28MP0009745_abnormal_behavioral_response1.87679634
29MP0002064_seizures1.82500774
30MP0006276_abnormal_autonomic_nervous1.80602274
31* MP0004484_altered_response_of1.74326117
32MP0002972_abnormal_cardiac_muscle1.69160923
33MP0008775_abnormal_heart_ventricle1.68409505
34MP0002063_abnormal_learning/memory/cond1.68173935
35MP0009780_abnormal_chondrocyte_physiolo1.65865440
36MP0005423_abnormal_somatic_nervous1.65522351
37MP0002067_abnormal_sensory_capabilities1.64003566
38MP0004858_abnormal_nervous_system1.63668871
39MP0002272_abnormal_nervous_system1.61271320
40MP0004145_abnormal_muscle_electrophysio1.59907690
41MP0002163_abnormal_gland_morphology1.59666489
42MP0003890_abnormal_embryonic-extraembry1.57708317
43MP0001501_abnormal_sleep_pattern1.56161390
44MP0002295_abnormal_pulmonary_circulatio1.54798981
45MP0003136_yellow_coat_color1.52822851
46MP0002572_abnormal_emotion/affect_behav1.50917173
47MP0004085_abnormal_heartbeat1.50710937
48MP0003045_fibrosis1.50132067
49MP0001970_abnormal_pain_threshold1.49849889
50MP0002733_abnormal_thermal_nociception1.49179876
51MP0008569_lethality_at_weaning1.49027132
52MP0003279_aneurysm1.47403711
53MP0001485_abnormal_pinna_reflex1.45393247
54MP0005620_abnormal_muscle_contractility1.44271396
55MP0005084_abnormal_gallbladder_morpholo1.43649801
56MP0002102_abnormal_ear_morphology1.42135995
57MP0005379_endocrine/exocrine_gland_phen1.40910907
58MP0002938_white_spotting1.40718680
59MP0001666_abnormal_nutrient_absorption1.40075950
60MP0003950_abnormal_plasma_membrane1.39637066
61MP0003941_abnormal_skin_development1.39601403
62MP0001440_abnormal_grooming_behavior1.39254352
63MP0005623_abnormal_meninges_morphology1.37693490
64MP0002909_abnormal_adrenal_gland1.36274701
65MP0004130_abnormal_muscle_cell1.34388608
66MP0002090_abnormal_vision1.34035104
67MP0001486_abnormal_startle_reflex1.33575883
68MP0008877_abnormal_DNA_methylation1.31472689
69MP0000639_abnormal_adrenal_gland1.30878463
70MP0004924_abnormal_behavior1.29773857
71MP0005386_behavior/neurological_phenoty1.29773857
72MP0002184_abnormal_innervation1.29659091
73MP0005330_cardiomyopathy1.27640935
74MP0004087_abnormal_muscle_fiber1.27479525
75MP0005645_abnormal_hypothalamus_physiol1.27434567
76MP0005253_abnormal_eye_physiology1.24238191
77MP0005187_abnormal_penis_morphology1.20448139
78MP0001299_abnormal_eye_distance/1.16066936
79MP0003137_abnormal_impulse_conducting1.15576690
80MP0003385_abnormal_body_wall1.15543756
81MP0006072_abnormal_retinal_apoptosis1.13228407
82MP0002138_abnormal_hepatobiliary_system1.10993941
83MP0000013_abnormal_adipose_tissue1.10183560
84MP0008438_abnormal_cutaneous_collagen1.09577855
85MP0003937_abnormal_limbs/digits/tail_de1.09087339
86MP0001958_emphysema1.07782759
87MP0004133_heterotaxia1.07545396
88MP0005503_abnormal_tendon_morphology1.07426415
89MP0004233_abnormal_muscle_weight1.06905871
90MP0008004_abnormal_stomach_pH1.03683595
91MP0000427_abnormal_hair_cycle1.03657922
92MP0003828_pulmonary_edema1.02619722
93MP0004885_abnormal_endolymph1.01967919
94MP0001544_abnormal_cardiovascular_syste1.01534965
95MP0005385_cardiovascular_system_phenoty1.01534965
96MP0010329_abnormal_lipoprotein_level1.01092579
97MP0002106_abnormal_muscle_physiology0.99626092
98MP0001879_abnormal_lymphatic_vessel0.99412903
99MP0000747_muscle_weakness0.97584402
100MP0004811_abnormal_neuron_physiology0.97428706
101MP0001502_abnormal_circadian_rhythm0.97156649
102MP0003091_abnormal_cell_migration0.97143979
103MP0002638_abnormal_pupillary_reflex0.96928452
104MP0002557_abnormal_social/conspecific_i0.95594134
105MP0005275_abnormal_skin_tensile0.94618738
106MP0009384_cardiac_valve_regurgitation0.94183338
107MP0010386_abnormal_urinary_bladder0.93231985
108MP0002882_abnormal_neuron_morphology0.92493426
109MP0003183_abnormal_peptide_metabolism0.92198915
110MP0003283_abnormal_digestive_organ0.92046253
111MP0003119_abnormal_digestive_system0.91017038
112MP0004019_abnormal_vitamin_homeostasis0.90728432
113MP0002332_abnormal_exercise_endurance0.90616753
114MP0003633_abnormal_nervous_system0.90510522
115MP0002229_neurodegeneration0.88966732
116MP0010630_abnormal_cardiac_muscle0.88489176
117MP0005369_muscle_phenotype0.86947707
118MP0001756_abnormal_urination0.86721678
119MP0000759_abnormal_skeletal_muscle0.84907684
120MP0003787_abnormal_imprinting0.83893598
121MP0003122_maternal_imprinting0.82752780
122MP0006138_congestive_heart_failure0.82214159
123MP0002233_abnormal_nose_morphology0.81057029
124MP0003935_abnormal_craniofacial_develop0.80280433
125MP0003195_calcinosis0.79128449
126MP0000778_abnormal_nervous_system0.78360362
127MP0001986_abnormal_taste_sensitivity0.77697097
128MP0001188_hyperpigmentation0.76364682
129MP0002127_abnormal_cardiovascular_syste0.74220351
130MP0003221_abnormal_cardiomyocyte_apopto0.74036309
131MP0000604_amyloidosis0.73871506
132MP0002822_catalepsy0.73575055
133MP0000750_abnormal_muscle_regeneration0.72352115
134MP0002933_joint_inflammation0.72276530
135MP0005365_abnormal_bile_salt0.71600906
136MP0003121_genomic_imprinting0.69366681
137MP0002066_abnormal_motor_capabilities/c0.68511862
138MP0002108_abnormal_muscle_morphology0.68091667
139MP0004272_abnormal_basement_membrane0.67138425
140MP0005332_abnormal_amino_acid0.66903777
141MP0005195_abnormal_posterior_eye0.66767823
142MP0002139_abnormal_hepatobiliary_system0.66472832
143MP0002128_abnormal_blood_circulation0.64753583
144MP0004043_abnormal_pH_regulation0.64339491
145MP0003755_abnormal_palate_morphology0.63837692
146MP0000428_abnormal_craniofacial_morphol0.63417906
147MP0000534_abnormal_ureter_morphology0.63297196
148MP0000613_abnormal_salivary_gland0.63246327
149MP0000767_abnormal_smooth_muscle0.63057096
150MP0002168_other_aberrant_phenotype0.62814527
151MP0003786_premature_aging0.62662549
152MP0000647_abnormal_sebaceous_gland0.61942090
153MP0005174_abnormal_tail_pigmentation0.61328661
154MP0003943_abnormal_hepatobiliary_system0.61143987
155MP0002928_abnormal_bile_duct0.59796927
156MP0004264_abnormal_extraembryonic_tissu0.58414997

Predicted human phenotypes

RankGene SetZ-score
1Hypoalphalipoproteinemia (HP:0003233)5.50214219
2Facial diplegia (HP:0001349)4.21703204
3Congenital stationary night blindness (HP:0007642)3.95159306
4Congenital malformation of the right heart (HP:0011723)3.92060154
5Double outlet right ventricle (HP:0001719)3.92060154
6Intestinal atresia (HP:0011100)3.91019705
7Sudden death (HP:0001699)3.75328505
8Abnormal pancreas size (HP:0012094)3.60484209
9Hypolipoproteinemia (HP:0010981)3.58888035
10Atrial fibrillation (HP:0005110)3.52708311
11Aplasia/Hypoplasia of the tibia (HP:0005772)3.50825522
12Febrile seizures (HP:0002373)3.49636012
13Central scotoma (HP:0000603)3.47724762
14Primary atrial arrhythmia (HP:0001692)3.38167804
15Prolonged QT interval (HP:0001657)3.34295526
16Syncope (HP:0001279)3.30465299
17Short tibia (HP:0005736)3.27950977
18Supraventricular tachycardia (HP:0004755)3.16546495
19Focal seizures (HP:0007359)3.12046489
20Supraventricular arrhythmia (HP:0005115)3.09566377
21Atonic seizures (HP:0010819)3.06882396
22Focal motor seizures (HP:0011153)3.05028508
23Vitreoretinal degeneration (HP:0000655)3.04688524
24Progressive cerebellar ataxia (HP:0002073)3.00994478
25Renal cortical cysts (HP:0000803)2.96089218
26Hypoplastic ischia (HP:0003175)2.88572277
27Abnormality of the calf musculature (HP:0001430)2.83500962
28Abnormality of the ischium (HP:0003174)2.82248167
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.82059970
30Action tremor (HP:0002345)2.78345124
31Visual hallucinations (HP:0002367)2.77844536
32Abnormality of macular pigmentation (HP:0008002)2.76761453
33Bifid tongue (HP:0010297)2.75913185
34Bradycardia (HP:0001662)2.75725506
35Epileptic encephalopathy (HP:0200134)2.75662237
36Nephronophthisis (HP:0000090)2.72496055
37Bony spicule pigmentary retinopathy (HP:0007737)2.68257110
38Calf muscle hypertrophy (HP:0008981)2.67880095
39Abnormal EKG (HP:0003115)2.65902505
40Scotoma (HP:0000575)2.64645505
41Ventricular fibrillation (HP:0001663)2.64104822
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.62943577
43Absent eyebrow (HP:0002223)2.59347203
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57580107
45Proximal tubulopathy (HP:0000114)2.56159327
46Myotonia (HP:0002486)2.55712532
47Abnormal rod and cone electroretinograms (HP:0008323)2.50343157
48Absence seizures (HP:0002121)2.44196376
49Absent frontal sinuses (HP:0002688)2.43810652
50Muscle hypertrophy of the lower extremities (HP:0008968)2.40740175
51Abnormality of midbrain morphology (HP:0002418)2.37099320
52Molar tooth sign on MRI (HP:0002419)2.37099320
53Epiphyseal dysplasia (HP:0002656)2.35530392
54Amelogenesis imperfecta (HP:0000705)2.34467352
55Areflexia of lower limbs (HP:0002522)2.33251324
56Hyperglycinemia (HP:0002154)2.27065288
57Hypoventilation (HP:0002791)2.25950310
58Pancreatic cysts (HP:0001737)2.25547744
59Dysmetric saccades (HP:0000641)2.24948225
60Exercise-induced muscle cramps (HP:0003710)2.22753614
61Bundle branch block (HP:0011710)2.21396233
62Pheochromocytoma (HP:0002666)2.20185322
63Ventricular arrhythmia (HP:0004308)2.20133009
64Lower limb amyotrophy (HP:0007210)2.18235384
65Vertebral arch anomaly (HP:0008438)2.18194933
66True hermaphroditism (HP:0010459)2.17431429
67Truncal ataxia (HP:0002078)2.16343125
68Cupped ribs (HP:0000887)2.15708462
69Agammaglobulinemia (HP:0004432)2.15390302
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.14535668
71Genetic anticipation (HP:0003743)2.14316412
72Fragile skin (HP:0001030)2.13989632
73Myokymia (HP:0002411)2.13974978
74Dyschromatopsia (HP:0007641)2.13813562
75Large for gestational age (HP:0001520)2.11433966
76Abnormality of the renal medulla (HP:0100957)2.09367822
77Dialeptic seizures (HP:0011146)2.08599780
78Hyporeflexia of lower limbs (HP:0002600)2.07601188
79Abnormal ventriculo-arterial connection (HP:0011563)2.06271299
80Transposition of the great arteries (HP:0001669)2.06271299
81Abnormal connection of the cardiac segments (HP:0011545)2.06271299
82Occipital encephalocele (HP:0002085)2.05508762
83Cerebral hypomyelination (HP:0006808)2.04956982
84Ectropion (HP:0000656)2.04627261
85Broad-based gait (HP:0002136)2.04535705
86Exercise-induced myalgia (HP:0003738)2.03445732
87Glycosuria (HP:0003076)2.00019911
88Abnormality of urine glucose concentration (HP:0011016)2.00019911
89Abnormality of the renal cortex (HP:0011035)1.99559734
90EMG: myopathic abnormalities (HP:0003458)1.99469218
91Pancreatic fibrosis (HP:0100732)1.98600692
92Lipoatrophy (HP:0100578)1.97911056
93Aortic aneurysm (HP:0004942)1.97536042
94Genital tract atresia (HP:0001827)1.96517586
95Right ventricular cardiomyopathy (HP:0011663)1.96451650
96Neuroendocrine neoplasm (HP:0100634)1.95094001
97Hemiparesis (HP:0001269)1.94603705
98Distal lower limb amyotrophy (HP:0008944)1.94544520
99Medial flaring of the eyebrow (HP:0010747)1.94210205
100Anal stenosis (HP:0002025)1.92959744
101Vaginal atresia (HP:0000148)1.92854795
102Choroideremia (HP:0001139)1.92191110
103Popliteal pterygium (HP:0009756)1.90059841
104Ventricular tachycardia (HP:0004756)1.88835609
105Pigmentary retinal degeneration (HP:0001146)1.88191115
106Generalized tonic-clonic seizures (HP:0002069)1.87809234
107Chorioretinal atrophy (HP:0000533)1.87712994
108Nemaline bodies (HP:0003798)1.85320067
109Hyperventilation (HP:0002883)1.84830321
110Absent speech (HP:0001344)1.84784931
111Cerebellar dysplasia (HP:0007033)1.84455777
112Abnormality of the parathyroid morphology (HP:0011766)1.83749055
113Hypoglycemic coma (HP:0001325)1.82731540
114Preaxial foot polydactyly (HP:0001841)1.82465171
115Abnormality of alanine metabolism (HP:0010916)1.82249747
116Hyperalaninemia (HP:0003348)1.82249747
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82249747
118Limited hip movement (HP:0008800)1.82141541
119Soft skin (HP:0000977)1.81569829
120Small hand (HP:0200055)1.79224792
121Hypothermia (HP:0002045)1.79043934
122Asymmetry of the thorax (HP:0001555)1.78252805
123Muscle fiber splitting (HP:0003555)1.78164186
124Hyperglycemia (HP:0003074)1.77247918
125Impaired pain sensation (HP:0007328)1.76856132
126Abnormality of pain sensation (HP:0010832)1.76856132
127Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76589964
128Short chin (HP:0000331)1.76289791
129Increased connective tissue (HP:0009025)1.75695704
130Increased corneal curvature (HP:0100692)1.74278480
131Keratoconus (HP:0000563)1.74278480
132Increased CSF protein (HP:0002922)1.74106262
133Left ventricular hypertrophy (HP:0001712)1.73895979
134Hypercortisolism (HP:0001578)1.73088814
135Renal hypoplasia (HP:0000089)1.72490535
136Papilledema (HP:0001085)1.72105812
137Ulnar claw (HP:0001178)1.71946036
138Disproportionate short-trunk short stature (HP:0003521)1.71870018
139Palpitations (HP:0001962)1.71421309
140Urinary bladder sphincter dysfunction (HP:0002839)1.71024213
141Flat acetabular roof (HP:0003180)1.70692327
142Stage 5 chronic kidney disease (HP:0003774)1.70386695
143Small epiphyses (HP:0010585)1.69855324
144Steppage gait (HP:0003376)1.69533912
145Vascular tortuosity (HP:0004948)1.69393741
146Preauricular pit (HP:0004467)1.69393264
147Periauricular skin pits (HP:0100277)1.69393264
148Gaze-evoked nystagmus (HP:0000640)1.69289888
149Narrow forehead (HP:0000341)1.68864548
150Muscle fiber inclusion bodies (HP:0100299)1.68691800
151Acute lymphatic leukemia (HP:0006721)1.68229616
152Delayed gross motor development (HP:0002194)1.68070360
153Postaxial foot polydactyly (HP:0001830)1.67729199
154Lower limb asymmetry (HP:0100559)1.67240662
155Prominent supraorbital ridges (HP:0000336)1.66996580
156Foot dorsiflexor weakness (HP:0009027)1.66554479
157Neonatal short-limb short stature (HP:0008921)1.66375802
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66324034
159Supranuclear gaze palsy (HP:0000605)1.65467734
160Gastrointestinal atresia (HP:0002589)1.64617877
161Pulmonic stenosis (HP:0001642)1.64184724
162Postaxial hand polydactyly (HP:0001162)1.64058667
163Dysdiadochokinesis (HP:0002075)1.63840133
164Volvulus (HP:0002580)1.62237473
165Concave nail (HP:0001598)1.61931355
166Abnormality of vitamin B metabolism (HP:0004340)1.61690787
167Irregular epiphyses (HP:0010582)1.61658610
168Methylmalonic acidemia (HP:0002912)1.61204795
169Abnormality of the frontal sinuses (HP:0002687)1.60907719
170Increased variability in muscle fiber diameter (HP:0003557)1.60699928
171Single umbilical artery (HP:0001195)1.60414253
172Abnormality of the fetal cardiovascular system (HP:0010948)1.60414253
173Abnormal umbilical cord blood vessels (HP:0011403)1.60414253
174Arterial tortuosity (HP:0005116)1.59395765
175Macroorchidism (HP:0000053)1.59272100
176Oculomotor apraxia (HP:0000657)1.59009692
177Abnormality of the foot musculature (HP:0001436)1.56821099
178Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56595524
179Abnormality of the pubic bones (HP:0003172)1.56553926
180Aqueductal stenosis (HP:0002410)1.55912886
181Lumbar hyperlordosis (HP:0002938)1.55274421
182Decreased central vision (HP:0007663)1.54804301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM287.00520561
2MAP4K23.76579466
3BCR3.45404744
4BRD42.45410002
5CASK2.34787578
6FRK2.31592168
7NTRK32.18966233
8LMTK22.17181445
9MAP3K42.16142979
10MINK12.07454727
11PHKG12.03294897
12PHKG22.03294897
13MAP3K121.98709106
14STK241.96311811
15OBSCN1.85634624
16RIPK41.81264638
17MYLK1.73174771
18MAP3K131.68201160
19PLK21.68026874
20WNK31.62464820
21MAP2K71.60963761
22CAMKK21.59683085
23PDK21.55128222
24SGK21.54339822
25STK391.53993517
26ERBB31.52239325
27TTN1.51568354
28SIK21.50252486
29NLK1.47086312
30MUSK1.45324104
31PIK3CA1.45222627
32MARK11.44700121
33ACVR1B1.44009887
34BMPR1B1.41697666
35STK31.40996338
36MAPK131.40991626
37MAP3K91.40244837
38SIK31.40114437
39PRKCH1.36041913
40RIPK11.33640965
41SGK31.30271874
42PRKD31.27763552
43PNCK1.26979777
44GRK51.25766531
45PAK31.24766903
46WNK11.23034092
47FGFR31.22835892
48DAPK21.21754877
49DMPK1.17589082
50CAMKK11.17369430
51MAPK121.17317139
52GRK71.16367134
53MAP2K41.15206781
54MST41.12215164
55CAMK1G1.07579996
56JAK11.05885634
57CDC42BPA1.05638758
58SGK4941.03268112
59SGK2231.03268112
60PAK61.01985699
61STK38L0.99611496
62NTRK10.98153493
63NTRK20.97821131
64ERBB40.97379207
65MST1R0.96099403
66ROCK10.94044980
67GRK10.93009950
68STK380.92091882
69EIF2AK30.89858568
70FER0.89082776
71LIMK10.89026946
72PBK0.88826154
73FES0.86651715
74CDK50.85343148
75RET0.83901817
76TRPM70.83103838
77PRKCE0.81674621
78MAP3K140.81633967
79CAMK2A0.79927002
80CAMK10.79817700
81TNIK0.77220523
82OXSR10.76867040
83MET0.76521101
84NUAK10.76517950
85* CAMK2D0.75467602
86STK160.75341732
87NEK10.73466787
88SGK10.72905846
89NEK90.71786808
90CAMK1D0.70964158
91TGFBR20.70773698
92MAP3K70.69887527
93PTK2B0.67587886
94KSR10.65978142
95WEE10.65801164
96PRKG20.65318233
97PIK3CG0.65205945
98RPS6KA20.63615716
99PDK10.62337472
100CAMK40.62126331
101PRPF4B0.61686823
102ROCK20.61126820
103MELK0.58814471
104MAPK70.58361598
105PRKCG0.58299946
106EPHA40.56323889
107ADRBK10.56044096
108DDR20.54691406
109FGFR10.53430824
110LATS10.53390635
111MAP3K20.52877827
112PINK10.52459097
113ZAK0.52295411
114FYN0.52258608
115WNK40.52253750
116TNK20.50117576
117MAP3K50.48983641
118STK110.47952764
119MAP2K10.47865542
120NEK20.47675806
121PLK30.47433647
122TIE10.46170705
123PRKD10.45939191
124KSR20.45521719
125MKNK20.42281923
126SYK0.41303224
127AKT30.41291186
128PKN20.41139593
129PRKG10.40608721
130DAPK30.39601329
131DYRK1A0.38877592
132SCYL20.38409441
133LATS20.38012499
134HIPK20.37338841
135FGFR20.37177598
136ADRBK20.33256580
137TGFBR10.31625913
138CSNK1G10.28676544
139CSNK1G20.26975016
140BCKDK0.26556787
141INSRR0.26497004
142EIF2AK20.26190182
143PRKACA0.25845506
144PKN10.25677517
145EGFR0.24403237
146STK40.22380684
147INSR0.20438357
148TAF10.15912219
149ABL10.15624207
150* PRKCB0.15494945
151PRKACB0.14401859

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.13872347
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.01747436
3Protein export_Homo sapiens_hsa030603.00398431
4Phototransduction_Homo sapiens_hsa047442.91580754
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85916471
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66135293
7* Olfactory transduction_Homo sapiens_hsa047402.40371528
8Synaptic vesicle cycle_Homo sapiens_hsa047212.39941739
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.29278482
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20807831
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.16435686
12Nicotine addiction_Homo sapiens_hsa050332.15549622
13Butanoate metabolism_Homo sapiens_hsa006502.08177955
14TGF-beta signaling pathway_Homo sapiens_hsa043502.05023299
15Fat digestion and absorption_Homo sapiens_hsa049752.04490893
16Vitamin B6 metabolism_Homo sapiens_hsa007502.02314905
17Dilated cardiomyopathy_Homo sapiens_hsa054141.86970082
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82695492
19Nitrogen metabolism_Homo sapiens_hsa009101.78146205
20* Circadian entrainment_Homo sapiens_hsa047131.77251480
21Morphine addiction_Homo sapiens_hsa050321.74584882
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69484177
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68660155
24GABAergic synapse_Homo sapiens_hsa047271.68391855
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63945682
26Glutamatergic synapse_Homo sapiens_hsa047241.60524752
27Salivary secretion_Homo sapiens_hsa049701.58345782
28Cardiac muscle contraction_Homo sapiens_hsa042601.55606976
29* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55255281
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.54919907
31Renin secretion_Homo sapiens_hsa049241.46391766
32* Cholinergic synapse_Homo sapiens_hsa047251.44742139
33* Long-term potentiation_Homo sapiens_hsa047201.44263416
34* Oxytocin signaling pathway_Homo sapiens_hsa049211.40646622
35* Dopaminergic synapse_Homo sapiens_hsa047281.40303071
36Taste transduction_Homo sapiens_hsa047421.38824990
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38691522
38* Gastric acid secretion_Homo sapiens_hsa049711.36916724
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31756024
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31434147
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30928025
42Long-term depression_Homo sapiens_hsa047301.30424021
43Serotonergic synapse_Homo sapiens_hsa047261.29210369
44* Insulin secretion_Homo sapiens_hsa049111.27082633
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24675826
46* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22023534
47* Calcium signaling pathway_Homo sapiens_hsa040201.21834500
48Collecting duct acid secretion_Homo sapiens_hsa049661.19320537
49Basal transcription factors_Homo sapiens_hsa030221.19232019
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18658040
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18150680
52Peroxisome_Homo sapiens_hsa041461.17102888
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15823694
54Fatty acid elongation_Homo sapiens_hsa000621.13999428
55Type II diabetes mellitus_Homo sapiens_hsa049301.13847786
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12193440
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11237185
58Linoleic acid metabolism_Homo sapiens_hsa005911.10718841
59* Amphetamine addiction_Homo sapiens_hsa050311.09180011
60Fatty acid degradation_Homo sapiens_hsa000711.08570217
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06461444
62Mineral absorption_Homo sapiens_hsa049781.05309497
63* GnRH signaling pathway_Homo sapiens_hsa049121.03731857
64* cAMP signaling pathway_Homo sapiens_hsa040241.03461164
65* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03455908
66Hedgehog signaling pathway_Homo sapiens_hsa043401.02374971
67beta-Alanine metabolism_Homo sapiens_hsa004101.00250104
68Tight junction_Homo sapiens_hsa045300.98617199
69Fatty acid metabolism_Homo sapiens_hsa012120.98222124
70Hippo signaling pathway_Homo sapiens_hsa043900.97773403
71Ether lipid metabolism_Homo sapiens_hsa005650.96643559
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96446760
73Retinol metabolism_Homo sapiens_hsa008300.93027674
74Caffeine metabolism_Homo sapiens_hsa002320.92511433
75Vibrio cholerae infection_Homo sapiens_hsa051100.92254743
76ABC transporters_Homo sapiens_hsa020100.90597906
77Gap junction_Homo sapiens_hsa045400.90231260
78Cocaine addiction_Homo sapiens_hsa050300.90095099
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.89413958
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88967689
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88871439
82B cell receptor signaling pathway_Homo sapiens_hsa046620.87455144
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86604199
84Estrogen signaling pathway_Homo sapiens_hsa049150.83434642
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82601368
86Pyruvate metabolism_Homo sapiens_hsa006200.82561296
87Selenocompound metabolism_Homo sapiens_hsa004500.81536053
88Focal adhesion_Homo sapiens_hsa045100.80912544
89PPAR signaling pathway_Homo sapiens_hsa033200.80640053
90* Glioma_Homo sapiens_hsa052140.80259852
91Tryptophan metabolism_Homo sapiens_hsa003800.80104952
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80077959
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78902149
94* Neurotrophin signaling pathway_Homo sapiens_hsa047220.78659826
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78164507
96ECM-receptor interaction_Homo sapiens_hsa045120.76637812
97MAPK signaling pathway_Homo sapiens_hsa040100.75995928
98Platelet activation_Homo sapiens_hsa046110.75255277
99Arginine and proline metabolism_Homo sapiens_hsa003300.74865542
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74262077
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.73611737
102Dorso-ventral axis formation_Homo sapiens_hsa043200.71688618
103Rheumatoid arthritis_Homo sapiens_hsa053230.71285055
104mTOR signaling pathway_Homo sapiens_hsa041500.70489705
105Adherens junction_Homo sapiens_hsa045200.69032635
106Osteoclast differentiation_Homo sapiens_hsa043800.68577750
107Sulfur metabolism_Homo sapiens_hsa009200.68226158
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68068712
109Thyroid hormone synthesis_Homo sapiens_hsa049180.67804246
110Axon guidance_Homo sapiens_hsa043600.67327321
111Sphingolipid metabolism_Homo sapiens_hsa006000.66961740
112Viral myocarditis_Homo sapiens_hsa054160.66626174
113Pancreatic secretion_Homo sapiens_hsa049720.66514235
114Chemokine signaling pathway_Homo sapiens_hsa040620.66513491
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66178790
116Salmonella infection_Homo sapiens_hsa051320.65501779
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.65034370
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64980768
119Insulin signaling pathway_Homo sapiens_hsa049100.64263649
120Phagosome_Homo sapiens_hsa041450.63859631
121Steroid biosynthesis_Homo sapiens_hsa001000.63766877
122* ErbB signaling pathway_Homo sapiens_hsa040120.63659591
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62639832
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62077221
125Inositol phosphate metabolism_Homo sapiens_hsa005620.61700340
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60825112
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60243178
128Non-homologous end-joining_Homo sapiens_hsa034500.60189509
129Lysine degradation_Homo sapiens_hsa003100.59757347
130Ras signaling pathway_Homo sapiens_hsa040140.59576341
131* Oocyte meiosis_Homo sapiens_hsa041140.59549845
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59410732
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58352624
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57821894
135Rap1 signaling pathway_Homo sapiens_hsa040150.57396871
136Circadian rhythm_Homo sapiens_hsa047100.57183183
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57173644
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57038716
139Basal cell carcinoma_Homo sapiens_hsa052170.56987163
140* Wnt signaling pathway_Homo sapiens_hsa043100.55790303
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55372549
142Glutathione metabolism_Homo sapiens_hsa004800.54993425
143Endometrial cancer_Homo sapiens_hsa052130.54988302
144* Proteoglycans in cancer_Homo sapiens_hsa052050.54610169
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54585204
146* Melanogenesis_Homo sapiens_hsa049160.53628344
147VEGF signaling pathway_Homo sapiens_hsa043700.52953455
148* Tuberculosis_Homo sapiens_hsa051520.52553628
149Amoebiasis_Homo sapiens_hsa051460.51388346
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51079721
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.50869170
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50585548
153Choline metabolism in cancer_Homo sapiens_hsa052310.50576935
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50334757
155Protein digestion and absorption_Homo sapiens_hsa049740.50313370
156Regulation of autophagy_Homo sapiens_hsa041400.50205473
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49692167
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48611924
159Histidine metabolism_Homo sapiens_hsa003400.48600920
160Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48598475
161Melanoma_Homo sapiens_hsa052180.48595672
162Chemical carcinogenesis_Homo sapiens_hsa052040.48536566
163RNA degradation_Homo sapiens_hsa030180.48305317
164Toxoplasmosis_Homo sapiens_hsa051450.48296371
165Arginine biosynthesis_Homo sapiens_hsa002200.46831773

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