CAMK2N1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07334395
2vocalization behavior (GO:0071625)5.78304298
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.74867788
4synaptic vesicle exocytosis (GO:0016079)5.69642391
5synaptic vesicle maturation (GO:0016188)5.62604161
6locomotory exploration behavior (GO:0035641)5.61994496
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.60438652
8glutamate secretion (GO:0014047)5.54363325
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.48556222
10sodium ion export (GO:0071436)5.20134033
11regulation of glutamate receptor signaling pathway (GO:1900449)5.19139442
12regulation of synaptic vesicle exocytosis (GO:2000300)5.09372659
13neuronal action potential propagation (GO:0019227)4.98653737
14neuron cell-cell adhesion (GO:0007158)4.93674701
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.93257102
16protein localization to synapse (GO:0035418)4.83624378
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.60801955
18regulation of synaptic vesicle transport (GO:1902803)4.52591257
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.51885249
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.50363373
21regulation of neuronal synaptic plasticity (GO:0048168)4.47171809
22neurotransmitter secretion (GO:0007269)4.41746009
23cerebellar granule cell differentiation (GO:0021707)4.34663432
24exploration behavior (GO:0035640)4.32985400
25dendritic spine morphogenesis (GO:0060997)4.26516910
26central nervous system myelination (GO:0022010)4.24792128
27axon ensheathment in central nervous system (GO:0032291)4.24792128
28glutamate receptor signaling pathway (GO:0007215)4.21067504
29layer formation in cerebral cortex (GO:0021819)4.18135335
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.17228662
31neurotransmitter-gated ion channel clustering (GO:0072578)4.11383473
32regulation of synapse structural plasticity (GO:0051823)4.11154574
33neuron-neuron synaptic transmission (GO:0007270)4.10680368
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.10121285
35synaptic transmission, glutamatergic (GO:0035249)4.03184145
36regulation of dendritic spine morphogenesis (GO:0061001)3.94619186
37regulation of postsynaptic membrane potential (GO:0060078)3.92328613
38potassium ion homeostasis (GO:0055075)3.91093166
39potassium ion import (GO:0010107)3.90098899
40positive regulation of membrane potential (GO:0045838)3.89706261
41long-term memory (GO:0007616)3.86956470
42L-amino acid import (GO:0043092)3.86523514
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.80970390
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.78434870
45regulation of synaptic plasticity (GO:0048167)3.75714801
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.74237122
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71971032
48cellular sodium ion homeostasis (GO:0006883)3.71611638
49long-term synaptic potentiation (GO:0060291)3.70647692
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65475250
51positive regulation of neurotransmitter secretion (GO:0001956)3.63209543
52neurotransmitter transport (GO:0006836)3.63195984
53neuron recognition (GO:0008038)3.62212016
54behavioral response to cocaine (GO:0048148)3.61068584
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.60248585
56gamma-aminobutyric acid transport (GO:0015812)3.57675533
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.56971079
58amino acid import (GO:0043090)3.56825722
59presynaptic membrane assembly (GO:0097105)3.55957366
60positive regulation of neurotransmitter transport (GO:0051590)3.53985257
61cell communication by electrical coupling (GO:0010644)3.53662946
62regulation of neurotransmitter secretion (GO:0046928)3.52876551
63cellular potassium ion homeostasis (GO:0030007)3.52169630
64regulation of dendritic spine development (GO:0060998)3.52147232
65response to histamine (GO:0034776)3.51849134
66regulation of synapse maturation (GO:0090128)3.50809352
67activation of protein kinase A activity (GO:0034199)3.50374736
68regulation of vesicle fusion (GO:0031338)3.48559851
69regulation of neurotransmitter levels (GO:0001505)3.45525143
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45177381
71mating behavior (GO:0007617)3.44887572
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42850268
73transmission of nerve impulse (GO:0019226)3.42359996
74auditory behavior (GO:0031223)3.37721510
75prepulse inhibition (GO:0060134)3.35253030
76proline transport (GO:0015824)3.33070125
77neuromuscular process controlling balance (GO:0050885)3.32632928
78regulation of glutamate secretion (GO:0014048)3.31502416
79serotonin metabolic process (GO:0042428)3.30992505
80regulation of neurotransmitter transport (GO:0051588)3.30302580
81synaptic vesicle endocytosis (GO:0048488)3.29644415
82positive regulation of synapse maturation (GO:0090129)3.28482311
83regulation of voltage-gated calcium channel activity (GO:1901385)3.28345310
84presynaptic membrane organization (GO:0097090)3.28137806
85membrane depolarization (GO:0051899)3.25662171
86membrane hyperpolarization (GO:0060081)3.25094934
87detection of calcium ion (GO:0005513)3.24513278
88membrane depolarization during action potential (GO:0086010)3.22841884
89postsynaptic membrane organization (GO:0001941)3.21784071
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20655187
91synaptic transmission, dopaminergic (GO:0001963)3.17556830
92negative regulation of dendrite morphogenesis (GO:0050774)3.13722566
93intraspecies interaction between organisms (GO:0051703)3.13702287
94social behavior (GO:0035176)3.13702287
95response to auditory stimulus (GO:0010996)3.12891331
96positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11907254
97axonal fasciculation (GO:0007413)3.11637943
98positive regulation of synaptic transmission (GO:0050806)3.08579988
99positive regulation of dendritic spine development (GO:0060999)3.07582501
100learning (GO:0007612)3.07391146
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06361033
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06094016
103regulation of synaptic transmission (GO:0050804)3.03607441
104synaptic transmission (GO:0007268)3.02733235
105dendritic spine organization (GO:0097061)3.02577281
106synapse assembly (GO:0007416)3.02097246
107negative regulation of amino acid transport (GO:0051956)3.01382019
108regulation of ARF protein signal transduction (GO:0032012)3.01215925
109cerebellar Purkinje cell differentiation (GO:0021702)3.00138964
110fear response (GO:0042596)2.98404870
111cerebellar Purkinje cell layer development (GO:0021680)2.98286089
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98200839
113behavioral fear response (GO:0001662)2.97997848
114behavioral defense response (GO:0002209)2.97997848
115neuromuscular process controlling posture (GO:0050884)2.97793770
116primary amino compound metabolic process (GO:1901160)2.97523697
117striatum development (GO:0021756)2.93415599
118cell communication involved in cardiac conduction (GO:0086065)2.92212930
119neuronal ion channel clustering (GO:0045161)2.91917691
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90537331
121regulation of protein kinase A signaling (GO:0010738)2.90479877
122synaptic vesicle transport (GO:0048489)2.85875707
123establishment of synaptic vesicle localization (GO:0097480)2.85875707
124cell differentiation in hindbrain (GO:0021533)2.84882468
125neuromuscular synaptic transmission (GO:0007274)2.81101621
126acid secretion (GO:0046717)2.80395180
127membrane repolarization (GO:0086009)2.78249684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36642857
2GBX2_23144817_ChIP-Seq_PC3_Human3.53703834
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23788929
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14516068
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14262609
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.80298943
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78229664
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78229664
9REST_21632747_ChIP-Seq_MESCs_Mouse2.74164096
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72297382
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70279319
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57516459
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55393769
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54429680
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54226732
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51070155
17DROSHA_22980978_ChIP-Seq_HELA_Human2.50430404
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31213607
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29550058
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.19596008
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.18900575
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15917230
23TAF15_26573619_Chip-Seq_HEK293_Human2.14717424
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06140550
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97209595
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93337038
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91468803
28AR_21572438_ChIP-Seq_LNCaP_Human1.81977886
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81322911
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80876270
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80774684
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80653816
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71844914
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62705531
35SMAD4_21799915_ChIP-Seq_A2780_Human1.61803270
36* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58712401
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58703755
38* ERG_21242973_ChIP-ChIP_JURKAT_Human1.54384419
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54141113
40P300_19829295_ChIP-Seq_ESCs_Human1.41736655
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38630309
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.37381889
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36659772
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35879099
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35459397
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33139451
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.33081002
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.30468805
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30466940
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30463349
51ZNF274_21170338_ChIP-Seq_K562_Hela1.28597137
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22012373
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.21873175
54AR_25329375_ChIP-Seq_VCAP_Human1.20691589
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19350362
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19321425
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19149003
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18372558
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18041692
60* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17391132
61STAT3_23295773_ChIP-Seq_U87_Human1.17025820
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16202414
63* CTCF_27219007_Chip-Seq_Bcells_Human1.16195519
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16131568
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15581672
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14566848
67AR_19668381_ChIP-Seq_PC3_Human1.14018412
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13894585
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.13009179
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.12552120
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.12225562
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11416614
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10970970
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08581391
75* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07083958
76FUS_26573619_Chip-Seq_HEK293_Human1.06827271
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.06597940
78* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06384670
79VDR_22108803_ChIP-Seq_LS180_Human1.06267492
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06052823
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.05154067
82* TET1_21490601_ChIP-Seq_MESCs_Mouse1.05129573
83TP53_16413492_ChIP-PET_HCT116_Human1.03471172
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03331411
85TCF4_23295773_ChIP-Seq_U87_Human1.02880422
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02809346
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02389626
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.01726592
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00584081
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00371244
91RNF2_27304074_Chip-Seq_NSC_Mouse1.00150943
92RUNX2_22187159_ChIP-Seq_PCA_Human0.99960052
93BCAT_22108803_ChIP-Seq_LS180_Human0.98270914
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97964336
95AHR_22903824_ChIP-Seq_MCF-7_Human0.97092496
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95725635
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95459408
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.95251567
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93175485
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92661024
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.90998342
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.90896614
103* KDM2B_26808549_Chip-Seq_K562_Human0.90119362
104RXR_22108803_ChIP-Seq_LS180_Human0.89674881
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88899211
106TP53_18474530_ChIP-ChIP_U2OS_Human0.88291603
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.88126973
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88062479
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87584891
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87584891
111JUN_21703547_ChIP-Seq_K562_Human0.87541606
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86709619
113* NANOG_18555785_Chip-Seq_ESCs_Mouse0.85723448
114* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85598971
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85372587
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85074589
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84874921
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84480258
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80944070
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79684251
121* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77455259
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74021116
123DPY_21335234_ChIP-Seq_ESCs_Mouse0.72994443
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72193413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.59300444
2MP0003880_abnormal_central_pattern5.56149398
3MP0003635_abnormal_synaptic_transmissio4.31451535
4MP0009745_abnormal_behavioral_response3.66962619
5MP0004270_analgesia3.60586445
6MP0002063_abnormal_learning/memory/cond3.43875884
7MP0002822_catalepsy3.42819514
8MP0002064_seizures3.34649902
9MP0009046_muscle_twitch3.15594155
10MP0001968_abnormal_touch/_nociception3.05351018
11MP0002572_abnormal_emotion/affect_behav2.92009990
12MP0001486_abnormal_startle_reflex2.72377038
13MP0002272_abnormal_nervous_system2.67109113
14MP0005423_abnormal_somatic_nervous2.54410328
15MP0001501_abnormal_sleep_pattern2.54222350
16MP0002734_abnormal_mechanical_nocicepti2.48253622
17MP0001440_abnormal_grooming_behavior2.23974084
18MP0002736_abnormal_nociception_after2.17946055
19MP0009780_abnormal_chondrocyte_physiolo2.02790002
20MP0003123_paternal_imprinting2.01863162
21MP0002733_abnormal_thermal_nociception1.96771019
22MP0002067_abnormal_sensory_capabilities1.94984660
23MP0003329_amyloid_beta_deposits1.91011974
24MP0001970_abnormal_pain_threshold1.91006893
25MP0001529_abnormal_vocalization1.85949021
26MP0005386_behavior/neurological_phenoty1.85493999
27MP0004924_abnormal_behavior1.85493999
28MP0002909_abnormal_adrenal_gland1.82978046
29MP0008569_lethality_at_weaning1.80047942
30MP0003879_abnormal_hair_cell1.77602307
31MP0002735_abnormal_chemical_nociception1.75801552
32MP0002557_abnormal_social/conspecific_i1.72200960
33MP0001905_abnormal_dopamine_level1.60969817
34MP0002184_abnormal_innervation1.59604382
35MP0001984_abnormal_olfaction1.58536878
36MP0005646_abnormal_pituitary_gland1.58241462
37MP0004811_abnormal_neuron_physiology1.57907810
38MP0006276_abnormal_autonomic_nervous1.53708073
39MP0000778_abnormal_nervous_system1.51717318
40MP0002066_abnormal_motor_capabilities/c1.40803651
41MP0003633_abnormal_nervous_system1.38577304
42MP0000955_abnormal_spinal_cord1.36918695
43MP0004858_abnormal_nervous_system1.36545455
44MP0008872_abnormal_physiological_respon1.27990671
45MP0002882_abnormal_neuron_morphology1.27351963
46MP0001502_abnormal_circadian_rhythm1.23666295
47MP0001188_hyperpigmentation1.23429459
48MP0002837_dystrophic_cardiac_calcinosis1.17567923
49MP0005535_abnormal_body_temperature1.14426965
50MP0003631_nervous_system_phenotype1.13534730
51MP0000013_abnormal_adipose_tissue1.12552223
52MP0004885_abnormal_endolymph1.11446127
53MP0000566_synostosis1.10414109
54MP0004142_abnormal_muscle_tone1.10314854
55MP0008874_decreased_physiological_sensi1.10033545
56MP0010386_abnormal_urinary_bladder1.06173286
57MP0004145_abnormal_muscle_electrophysio1.01251949
58MP0003075_altered_response_to0.99887059
59MP0002152_abnormal_brain_morphology0.98923498
60MP0002069_abnormal_eating/drinking_beha0.96537570
61MP0003787_abnormal_imprinting0.96295877
62MP0001177_atelectasis0.94428919
63MP0003122_maternal_imprinting0.93939253
64MP0005409_darkened_coat_color0.92413280
65MP0003121_genomic_imprinting0.92371662
66MP0000751_myopathy0.92314511
67MP0001986_abnormal_taste_sensitivity0.90616127
68MP0004742_abnormal_vestibular_system0.89409911
69MP0000604_amyloidosis0.89362602
70MP0002090_abnormal_vision0.88768216
71MP0005645_abnormal_hypothalamus_physiol0.88133966
72MP0004085_abnormal_heartbeat0.87279745
73MP0010234_abnormal_vibrissa_follicle0.85673570
74MP0005551_abnormal_eye_electrophysiolog0.85662315
75MP0008961_abnormal_basal_metabolism0.85538131
76MP0002229_neurodegeneration0.84097442
77MP0003690_abnormal_glial_cell0.81706145
78MP0003283_abnormal_digestive_organ0.80882627
79MP0002876_abnormal_thyroid_physiology0.80579628
80MP0001664_abnormal_digestion0.79912926
81MP0000920_abnormal_myelination0.78622901
82MP0001963_abnormal_hearing_physiology0.75511877
83MP0004147_increased_porphyrin_level0.73292044
84MP0005167_abnormal_blood-brain_barrier0.73173327
85MP0003632_abnormal_nervous_system0.69997670
86MP0005499_abnormal_olfactory_system0.69963223
87MP0005394_taste/olfaction_phenotype0.69963223
88MP0004484_altered_response_of0.69404292
89MP0001346_abnormal_lacrimal_gland0.69237657
90MP0000639_abnormal_adrenal_gland0.68418102
91MP0004043_abnormal_pH_regulation0.67926661
92MP0002638_abnormal_pupillary_reflex0.67914795
93MP0000569_abnormal_digit_pigmentation0.67345527
94MP0000631_abnormal_neuroendocrine_gland0.67050427
95MP0004510_myositis0.66712366
96MP0004215_abnormal_myocardial_fiber0.66034408
97MP0000026_abnormal_inner_ear0.65721368
98MP0003634_abnormal_glial_cell0.64833040
99MP0001485_abnormal_pinna_reflex0.63272051
100MP0001348_abnormal_lacrimal_gland0.62871562
101MP0003938_abnormal_ear_development0.62247610
102MP0008877_abnormal_DNA_methylation0.61898577
103MP0001299_abnormal_eye_distance/0.59435764
104MP0002752_abnormal_somatic_nervous0.59403727
105MP0003861_abnormal_nervous_system0.57404404
106MP0001943_abnormal_respiration0.57348234
107MP0002089_abnormal_postnatal_growth/wei0.57206175
108MP0009379_abnormal_foot_pigmentation0.56320138
109MP0004130_abnormal_muscle_cell0.54389720
110MP0001765_abnormal_ion_homeostasis0.53969501
111MP0003183_abnormal_peptide_metabolism0.53248280
112MP0005623_abnormal_meninges_morphology0.51416372
113MP0003137_abnormal_impulse_conducting0.51327282
114MP0003956_abnormal_body_size0.49398345
115MP0005166_decreased_susceptibility_to0.47750016
116MP0005379_endocrine/exocrine_gland_phen0.46992086
117MP0010769_abnormal_survival0.46652998
118MP0010770_preweaning_lethality0.46050496

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.66189678
2Myokymia (HP:0002411)6.87595339
3Focal seizures (HP:0007359)6.24791565
4Visual hallucinations (HP:0002367)5.62052182
5Epileptic encephalopathy (HP:0200134)5.39038576
6Atonic seizures (HP:0010819)5.18623233
7Absence seizures (HP:0002121)4.71279363
8Febrile seizures (HP:0002373)4.46425111
9Dialeptic seizures (HP:0011146)4.27885782
10Generalized tonic-clonic seizures (HP:0002069)4.24675802
11Hyperventilation (HP:0002883)4.09455784
12Poor eye contact (HP:0000817)4.02827465
13Broad-based gait (HP:0002136)4.00563593
14Progressive cerebellar ataxia (HP:0002073)3.87886677
15Impaired social interactions (HP:0000735)3.56922184
16Abnormal social behavior (HP:0012433)3.56922184
17Gaze-evoked nystagmus (HP:0000640)3.54490636
18Amblyopia (HP:0000646)3.51562945
19Action tremor (HP:0002345)3.49928410
20Impaired vibration sensation in the lower limbs (HP:0002166)3.41921084
21Dysdiadochokinesis (HP:0002075)3.30617493
22Papilledema (HP:0001085)3.29385000
23Anxiety (HP:0000739)3.26712955
24Depression (HP:0000716)3.20176017
25Dysmetria (HP:0001310)3.17751419
26Ankle clonus (HP:0011448)3.14413014
27Truncal ataxia (HP:0002078)2.99829507
28Supranuclear gaze palsy (HP:0000605)2.99821424
29Akinesia (HP:0002304)2.99392240
30Urinary bladder sphincter dysfunction (HP:0002839)2.99374882
31Abnormal eating behavior (HP:0100738)2.89775064
32Cerebral inclusion bodies (HP:0100314)2.89399042
33Stereotypic behavior (HP:0000733)2.84935826
34Postural instability (HP:0002172)2.76446885
35Neurofibrillary tangles (HP:0002185)2.76120976
36Scanning speech (HP:0002168)2.73364890
37Impaired smooth pursuit (HP:0007772)2.72810077
38Status epilepticus (HP:0002133)2.72581094
39Epileptiform EEG discharges (HP:0011182)2.70948083
40Sleep apnea (HP:0010535)2.70633546
41Limb dystonia (HP:0002451)2.70611154
42Urinary urgency (HP:0000012)2.64930916
43Cerebral hypomyelination (HP:0006808)2.63815326
44EEG with generalized epileptiform discharges (HP:0011198)2.61135032
45Drooling (HP:0002307)2.60650889
46Excessive salivation (HP:0003781)2.60650889
47Torticollis (HP:0000473)2.58305666
48Hemiparesis (HP:0001269)2.55434694
49Absent speech (HP:0001344)2.52741925
50Inability to walk (HP:0002540)2.52556842
51Annular pancreas (HP:0001734)2.48492654
52Bradykinesia (HP:0002067)2.46361410
53Spastic gait (HP:0002064)2.46087624
54Progressive inability to walk (HP:0002505)2.44325947
55Focal dystonia (HP:0004373)2.41360564
56Hypsarrhythmia (HP:0002521)2.41084595
57Impaired vibratory sensation (HP:0002495)2.38578944
58Dysmetric saccades (HP:0000641)2.37963240
59Intention tremor (HP:0002080)2.35217523
60Generalized myoclonic seizures (HP:0002123)2.34548618
61Increased circulating renin level (HP:0000848)2.33865974
62Pheochromocytoma (HP:0002666)2.33439360
63Abnormality of ocular smooth pursuit (HP:0000617)2.33336353
64Genetic anticipation (HP:0003743)2.31309308
65Abnormality of the lower motor neuron (HP:0002366)2.29988869
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26042281
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.26042281
68Resting tremor (HP:0002322)2.25495899
69Mutism (HP:0002300)2.22468673
70Abnormality of binocular vision (HP:0011514)2.22324174
71Diplopia (HP:0000651)2.22324174
72Termporal pattern (HP:0011008)2.21207970
73Insidious onset (HP:0003587)2.21207970
74Craniofacial dystonia (HP:0012179)2.20923844
75Tetraplegia (HP:0002445)2.20589629
76Spastic tetraparesis (HP:0001285)2.18939759
77Hemiplegia (HP:0002301)2.18402099
78Delusions (HP:0000746)2.17951235
79Blue irides (HP:0000635)2.16796789
80Megalencephaly (HP:0001355)2.16119834
81Ventricular fibrillation (HP:0001663)2.15668177
82Fetal akinesia sequence (HP:0001989)2.15077176
83Gait ataxia (HP:0002066)2.12985806
84Insomnia (HP:0100785)2.10137898
85Ankyloglossia (HP:0010296)2.06678282
86Protruding tongue (HP:0010808)2.05881241
87Peripheral hypomyelination (HP:0007182)2.01284504
88Neuroendocrine neoplasm (HP:0100634)2.00336122
89Lower limb muscle weakness (HP:0007340)1.99033553
90Lower limb asymmetry (HP:0100559)1.98729536
91Apathy (HP:0000741)1.97807241
92Bronchomalacia (HP:0002780)1.96032179
93Morphological abnormality of the pyramidal tract (HP:0002062)1.93756393
94Agitation (HP:0000713)1.92961916
95Incomplete penetrance (HP:0003829)1.92909329
96Abnormality of the periventricular white matter (HP:0002518)1.90515716
97Rigidity (HP:0002063)1.87937140
98Psychosis (HP:0000709)1.86819224
99Syncope (HP:0001279)1.85627250
100Prolonged QT interval (HP:0001657)1.85605221
101Clumsiness (HP:0002312)1.85480085
102Choreoathetosis (HP:0001266)1.85101486
103Abnormality of salivation (HP:0100755)1.83138233
104Polyphagia (HP:0002591)1.82534311
105Clonus (HP:0002169)1.80671168
106Hyperthyroidism (HP:0000836)1.80200633
107Generalized hypopigmentation of hair (HP:0011358)1.79937698
108Abnormal EKG (HP:0003115)1.78022749
109Diminished motivation (HP:0000745)1.77447748
110Pointed chin (HP:0000307)1.77349757
111Thickened helices (HP:0000391)1.77076013
112Metabolic alkalosis (HP:0200114)1.76966788
113Spastic tetraplegia (HP:0002510)1.76142248
114Obstructive sleep apnea (HP:0002870)1.74925041
115Lower limb amyotrophy (HP:0007210)1.74034462
116Abnormality of the corticospinal tract (HP:0002492)1.73857576
117Abnormality of saccadic eye movements (HP:0000570)1.73313963
118Rapidly progressive (HP:0003678)1.73031739
119Neuronal loss in central nervous system (HP:0002529)1.69446547
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68377544
121Spinal canal stenosis (HP:0003416)1.63453409
122Diminished movement (HP:0002374)1.61091126
123CNS hypomyelination (HP:0003429)1.60625574
124Split foot (HP:0001839)1.60533951
125Hypoventilation (HP:0002791)1.59626597
126Aplasia of the phalanges of the hand (HP:0009802)1.58562882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.48688055
2NTRK34.23571584
3MAP3K93.73794163
4DAPK23.33929657
5RIPK43.01452563
6MAP3K42.79932859
7MAP2K72.34758461
8KSR22.31745210
9MAP3K122.29231860
10MINK12.29056195
11PAK62.15724250
12PNCK2.02669472
13MAP2K41.96439117
14PRKD31.95703889
15DAPK11.93713413
16NTRK11.93445148
17CAMKK11.89213254
18CASK1.82671856
19PLK21.72674274
20MARK11.71181338
21NTRK21.68133986
22ARAF1.64045637
23SIK21.63024774
24KSR11.57546692
25CDK51.53698604
26MAP3K131.49088628
27GRK51.48894693
28TNIK1.38659451
29CDK191.37992283
30BMPR21.30976138
31MAP3K21.30612415
32FES1.27235122
33CAMKK21.25751183
34CCNB11.20509122
35PRKCG1.15498050
36TYRO31.10786568
37UHMK11.10266651
38STK381.10232534
39RAF11.02680564
40RIPK11.01941076
41CAMK2A1.00060389
42PRPF4B0.98788607
43LIMK10.96143552
44PTK2B0.94118970
45MAPK130.93094192
46CAMK10.91312684
47TAOK10.90752648
48OXSR10.88622445
49STK110.86460540
50RET0.85756503
51CAMK2B0.85574354
52CDK180.85137562
53CDK150.84305976
54CDK140.82472146
55MAP3K10.77782475
56PINK10.75724762
57SGK2230.74695252
58SGK4940.74695252
59CDK11A0.73385779
60MAPKAPK50.73379760
61PDPK10.71212285
62SGK10.70473522
63PKN10.69075538
64PAK30.65861285
65PRKCH0.65603320
66DAPK30.65333815
67PDK10.65159490
68LATS20.63757669
69FGR0.62507909
70CSNK1G20.62345809
71BRSK10.61916222
72SGK20.60580070
73NME10.60333752
74MAP3K110.59104565
75AKT30.57826506
76TESK10.57057961
77TNK20.56982679
78CAMK1G0.54600570
79CAMK2D0.53512294
80WNK10.51410506
81MAP2K10.50580038
82CAMK2G0.50025746
83SGK30.47797836
84PRKCE0.47172477
85MARK20.46211680
86RPS6KA30.45481683
87DYRK1A0.44905128
88ERBB20.43884301
89PRKG20.43692804
90PRKCZ0.43509705
91ALK0.42661879
92PTK20.41673269
93ROCK20.40055144
94LMTK20.39982755
95PIK3CA0.39904861
96MAPK120.38950453
97DMPK0.38358053
98CAMK40.38279647
99BRAF0.37605381
100CSNK1E0.37132754
101FYN0.36079793
102MAPK100.35709193
103WNK40.35383897
104PRKG10.35150541
105PHKG10.34893451
106PHKG20.34893451
107MAP3K70.34675570
108MAPK70.34244858
109NEK60.34228784
110PRKD20.33469434
111FGFR20.32846030
112PRKACA0.32169349
113MOS0.31487454
114PRKCB0.29215774
115MAP3K60.28973740
116FER0.28774361
117STK390.28635589
118PRKCA0.28574594

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.64159741
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30481788
3Long-term potentiation_Homo sapiens_hsa047202.85385000
4Olfactory transduction_Homo sapiens_hsa047402.79036657
5Amphetamine addiction_Homo sapiens_hsa050312.76931021
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74558400
7Circadian entrainment_Homo sapiens_hsa047132.63793436
8GABAergic synapse_Homo sapiens_hsa047272.62987246
9Glutamatergic synapse_Homo sapiens_hsa047242.62112196
10Morphine addiction_Homo sapiens_hsa050322.51526454
11Salivary secretion_Homo sapiens_hsa049702.28971473
12Dopaminergic synapse_Homo sapiens_hsa047282.26525902
13Insulin secretion_Homo sapiens_hsa049112.06915470
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05273155
15Gastric acid secretion_Homo sapiens_hsa049711.97766299
16Renin secretion_Homo sapiens_hsa049241.96932877
17Cholinergic synapse_Homo sapiens_hsa047251.93169209
18Cocaine addiction_Homo sapiens_hsa050301.92003490
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86848441
20Oxytocin signaling pathway_Homo sapiens_hsa049211.77239982
21Collecting duct acid secretion_Homo sapiens_hsa049661.76507954
22Taste transduction_Homo sapiens_hsa047421.75059237
23Long-term depression_Homo sapiens_hsa047301.74350493
24Serotonergic synapse_Homo sapiens_hsa047261.72349174
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69632291
26Calcium signaling pathway_Homo sapiens_hsa040201.64094644
27Nitrogen metabolism_Homo sapiens_hsa009101.51932923
28GnRH signaling pathway_Homo sapiens_hsa049121.49679146
29Vitamin B6 metabolism_Homo sapiens_hsa007501.41915626
30Gap junction_Homo sapiens_hsa045401.35960956
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32936804
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23407775
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20581054
34cAMP signaling pathway_Homo sapiens_hsa040241.18256074
35Cardiac muscle contraction_Homo sapiens_hsa042601.17379302
36Estrogen signaling pathway_Homo sapiens_hsa049151.15799365
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10963419
38Glioma_Homo sapiens_hsa052141.08332688
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06537685
40Vibrio cholerae infection_Homo sapiens_hsa051101.05026878
41Melanogenesis_Homo sapiens_hsa049161.04679024
42Type II diabetes mellitus_Homo sapiens_hsa049301.03956998
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03632955
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03299825
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.00145136
46Pancreatic secretion_Homo sapiens_hsa049720.91584710
47ErbB signaling pathway_Homo sapiens_hsa040120.90970303
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89919127
49Axon guidance_Homo sapiens_hsa043600.88212008
50Dorso-ventral axis formation_Homo sapiens_hsa043200.85872132
51Histidine metabolism_Homo sapiens_hsa003400.84449377
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82952865
53Mineral absorption_Homo sapiens_hsa049780.82859741
54Oocyte meiosis_Homo sapiens_hsa041140.82818467
55Thyroid hormone synthesis_Homo sapiens_hsa049180.80665480
56Phototransduction_Homo sapiens_hsa047440.80585717
57Alzheimers disease_Homo sapiens_hsa050100.77466771
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75223713
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72535900
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.72205143
61VEGF signaling pathway_Homo sapiens_hsa043700.69196709
62Dilated cardiomyopathy_Homo sapiens_hsa054140.67679194
63Oxidative phosphorylation_Homo sapiens_hsa001900.67406002
64Glucagon signaling pathway_Homo sapiens_hsa049220.67007124
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66158795
66MAPK signaling pathway_Homo sapiens_hsa040100.64352746
67African trypanosomiasis_Homo sapiens_hsa051430.63539198
68Choline metabolism in cancer_Homo sapiens_hsa052310.59372569
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58545743
70Parkinsons disease_Homo sapiens_hsa050120.54816690
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53869015
72Arginine and proline metabolism_Homo sapiens_hsa003300.52546795
73Alcoholism_Homo sapiens_hsa050340.50220786
74Bile secretion_Homo sapiens_hsa049760.49724265
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.49068444
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49025272
77Prion diseases_Homo sapiens_hsa050200.48795456
78Rap1 signaling pathway_Homo sapiens_hsa040150.48375658
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.48008107
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47668576
81Ras signaling pathway_Homo sapiens_hsa040140.47347746
82Fatty acid biosynthesis_Homo sapiens_hsa000610.46757768
83Type I diabetes mellitus_Homo sapiens_hsa049400.45782678
84Circadian rhythm_Homo sapiens_hsa047100.44848487
85Inositol phosphate metabolism_Homo sapiens_hsa005620.42951828
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41122151
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40116818
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38984051
89mTOR signaling pathway_Homo sapiens_hsa041500.38939879
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37861555
91Phenylalanine metabolism_Homo sapiens_hsa003600.37029928
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35695349
93Wnt signaling pathway_Homo sapiens_hsa043100.35158476
94Non-small cell lung cancer_Homo sapiens_hsa052230.34693621
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34686266
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33488829
97Tight junction_Homo sapiens_hsa045300.32958897
98Hippo signaling pathway_Homo sapiens_hsa043900.32529913
99Renal cell carcinoma_Homo sapiens_hsa052110.32319557
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.31128185
101Endocytosis_Homo sapiens_hsa041440.30865606
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30353555
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29704722
104Insulin signaling pathway_Homo sapiens_hsa049100.29410305
105Protein digestion and absorption_Homo sapiens_hsa049740.29365663
106Arginine biosynthesis_Homo sapiens_hsa002200.28547847
107beta-Alanine metabolism_Homo sapiens_hsa004100.28206178
108Chemokine signaling pathway_Homo sapiens_hsa040620.26950205
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26900572
110Ovarian steroidogenesis_Homo sapiens_hsa049130.26800788
111Rheumatoid arthritis_Homo sapiens_hsa053230.24011843
112Butanoate metabolism_Homo sapiens_hsa006500.23527607
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22677817
114Huntingtons disease_Homo sapiens_hsa050160.21688690
115AMPK signaling pathway_Homo sapiens_hsa041520.21476085

Most similar genes based on co-expression Upload to Enrichr

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