CAMK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.39416922
2neuronal action potential propagation (GO:0019227)5.94709939
3locomotory exploration behavior (GO:0035641)5.94512317
4vocalization behavior (GO:0071625)5.90119591
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.75062392
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.73726738
7synaptic vesicle maturation (GO:0016188)5.55238809
8synaptic vesicle exocytosis (GO:0016079)5.41809508
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.29506927
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24649023
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.14619348
12regulation of synaptic vesicle exocytosis (GO:2000300)5.13724541
13cerebellar granule cell differentiation (GO:0021707)5.13521035
14protein localization to synapse (GO:0035418)5.11552013
15neurotransmitter-gated ion channel clustering (GO:0072578)5.06079110
16glutamate secretion (GO:0014047)5.04815486
17regulation of glutamate receptor signaling pathway (GO:1900449)5.00367463
18glutamate receptor signaling pathway (GO:0007215)4.97514560
19synaptic transmission, glutamatergic (GO:0035249)4.96121695
20neurotransmitter secretion (GO:0007269)4.67920870
21* neuron-neuron synaptic transmission (GO:0007270)4.64752628
22negative T cell selection (GO:0043383)4.61119178
23gamma-aminobutyric acid transport (GO:0015812)4.59625474
24neuron cell-cell adhesion (GO:0007158)4.57187528
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.54985275
26positive regulation of synapse maturation (GO:0090129)4.51316330
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.51231394
28regulation of synaptic vesicle transport (GO:1902803)4.50760019
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.48861683
30regulation of synapse structural plasticity (GO:0051823)4.46050218
31exploration behavior (GO:0035640)4.44306104
32positive regulation of membrane potential (GO:0045838)4.36420766
33negative thymic T cell selection (GO:0045060)4.32093269
34postsynaptic membrane organization (GO:0001941)4.30012195
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.27383741
36cerebellar Purkinje cell differentiation (GO:0021702)4.21113978
37gamma-aminobutyric acid signaling pathway (GO:0007214)4.20702497
38regulation of postsynaptic membrane potential (GO:0060078)4.17992272
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16337038
40presynaptic membrane assembly (GO:0097105)4.15211497
41regulation of neuronal synaptic plasticity (GO:0048168)4.13705288
42negative regulation of cell killing (GO:0031342)4.12488121
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.12488121
44auditory behavior (GO:0031223)4.09484616
45positive T cell selection (GO:0043368)4.07659987
46cellular potassium ion homeostasis (GO:0030007)4.07139653
47presynaptic membrane organization (GO:0097090)4.05550080
48regulation of ARF protein signal transduction (GO:0032012)4.03964962
49* long-term memory (GO:0007616)3.94078125
50mechanosensory behavior (GO:0007638)3.86688144
51prepulse inhibition (GO:0060134)3.85598827
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.82017672
53layer formation in cerebral cortex (GO:0021819)3.78123809
54positive regulation of neurotransmitter secretion (GO:0001956)3.75639147
55long-term synaptic potentiation (GO:0060291)3.75445259
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74074724
57dendritic spine morphogenesis (GO:0060997)3.73461378
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69824571
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.69798934
60regulation of neurotransmitter secretion (GO:0046928)3.68482130
61transmission of nerve impulse (GO:0019226)3.67349945
62response to histamine (GO:0034776)3.66529713
63neurotransmitter transport (GO:0006836)3.66021344
64regulation of synaptic plasticity (GO:0048167)3.63900506
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62521997
66neuromuscular process controlling balance (GO:0050885)3.62065452
67regulation of synapse maturation (GO:0090128)3.61571465
68behavioral response to cocaine (GO:0048148)3.61326508
69regulation of voltage-gated calcium channel activity (GO:1901385)3.60808512
70regulation of dendritic spine morphogenesis (GO:0061001)3.58004572
71membrane depolarization (GO:0051899)3.57925682
72response to pheromone (GO:0019236)3.55424860
73activated T cell proliferation (GO:0050798)3.52704299
74L-amino acid import (GO:0043092)3.50528080
75cell differentiation in hindbrain (GO:0021533)3.49362471
76positive regulation of gamma-delta T cell activation (GO:0046645)3.48878873
77sodium ion export (GO:0071436)3.48169722
78positive regulation of neurotransmitter transport (GO:0051590)3.48135309
79response to auditory stimulus (GO:0010996)3.46747061
80regulation of neurotransmitter transport (GO:0051588)3.46598376
81regulation of neurotransmitter levels (GO:0001505)3.46318738
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43492872
83regulation of isotype switching to IgG isotypes (GO:0048302)3.35942121
84membrane depolarization during action potential (GO:0086010)3.35937812
85membrane hyperpolarization (GO:0060081)3.35912885
86synapse assembly (GO:0007416)3.35505742
87activation of protein kinase A activity (GO:0034199)3.34486207
88T cell selection (GO:0045058)3.32939750
89response to interleukin-15 (GO:0070672)3.31645231
90adult walking behavior (GO:0007628)3.31491389
91learning (GO:0007612)3.28246490
92synaptic vesicle endocytosis (GO:0048488)3.26865479
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26758032
94cellular response to interleukin-15 (GO:0071350)3.26756092
95long term synaptic depression (GO:0060292)3.24799810
96behavioral fear response (GO:0001662)3.24043839
97behavioral defense response (GO:0002209)3.24043839
98thymic T cell selection (GO:0045061)3.23557067
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22544835
100regulation of B cell receptor signaling pathway (GO:0050855)3.22013090
101positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20845496
102positive regulation of dendritic spine development (GO:0060999)3.20308642
103regulation of vesicle fusion (GO:0031338)3.18279419
104regulation of dendritic spine development (GO:0060998)3.17795310
105positive regulation of dendritic spine morphogenesis (GO:0061003)3.16815198
106fear response (GO:0042596)3.16536229
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15773695
108neuromuscular process controlling posture (GO:0050884)3.14910559
109positive thymic T cell selection (GO:0045059)3.13687886
110visual learning (GO:0008542)3.12858059
111positive regulation of synaptic transmission (GO:0050806)3.09430465
112proline transport (GO:0015824)3.08725944
113* synaptic transmission (GO:0007268)3.08009019
114neuromuscular process (GO:0050905)3.07489966
115regulation of synaptic transmission (GO:0050804)3.02899357
116dendrite morphogenesis (GO:0048813)3.01656324
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97963060
118central nervous system projection neuron axonogenesis (GO:0021952)2.96181215
119phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.93744489
120potassium ion import (GO:0010107)2.88578592
121regulation of gamma-delta T cell differentiation (GO:0045586)2.88110404
122positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87715813
123T cell migration (GO:0072678)2.86194131
124tolerance induction (GO:0002507)2.82818757
125neuronal ion channel clustering (GO:0045161)2.80283204
126negative regulation of T cell mediated immunity (GO:0002710)2.79813400
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79513647
128negative regulation of neurotransmitter secretion (GO:0046929)2.79350522
129positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73771245
130regulation of Rap GTPase activity (GO:0032317)2.72896711
131positive regulation of granulocyte differentiation (GO:0030854)2.72865447
132neurotransmitter uptake (GO:0001504)2.72180746
133nerve growth factor signaling pathway (GO:0038180)2.71519518
134amino acid import (GO:0043090)2.71353055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.91938165
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01508415
3GBX2_23144817_ChIP-Seq_PC3_Human3.78691265
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54205407
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17635307
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17082058
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15908370
8REST_21632747_ChIP-Seq_MESCs_Mouse2.86020414
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.75759235
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74714538
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74714538
12DROSHA_22980978_ChIP-Seq_HELA_Human2.69083552
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64636398
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60463005
15RUNX_20019798_ChIP-Seq_JUKART_Human2.56499318
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52256857
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49702294
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48635695
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47504346
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45670124
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.43132174
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33866289
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.27209889
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24555405
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21338254
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18448445
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.16076960
28AR_21572438_ChIP-Seq_LNCaP_Human1.98757363
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96440011
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94559299
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87735878
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86386507
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80090426
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.77902423
35TAF15_26573619_Chip-Seq_HEK293_Human1.76673919
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76262090
37SMAD4_21799915_ChIP-Seq_A2780_Human1.73581564
38* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70459246
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69493560
40* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56821151
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56762741
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55478184
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47633634
44P300_19829295_ChIP-Seq_ESCs_Human1.38069607
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37337320
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.36522197
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31578976
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30898405
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28316554
50AR_25329375_ChIP-Seq_VCAP_Human1.27354118
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.27120783
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25918404
53* STAT3_23295773_ChIP-Seq_U87_Human1.25726837
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.25067284
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24434127
56ZNF274_21170338_ChIP-Seq_K562_Hela1.22556625
57AR_19668381_ChIP-Seq_PC3_Human1.22415249
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22301888
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19697002
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18504773
61TCF4_23295773_ChIP-Seq_U87_Human1.17449582
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16876849
63* MYB_26560356_Chip-Seq_TH2_Human1.16869090
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14932377
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.14186714
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.13708265
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.12787462
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12640809
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.11755045
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.11673121
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11207227
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10993782
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.09687454
74TP53_16413492_ChIP-PET_HCT116_Human1.09425991
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09282474
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08129959
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08044980
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07268245
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05324353
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05221199
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.04264523
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03913400
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03806157
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03348957
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.03193408
86RNF2_27304074_Chip-Seq_NSC_Mouse1.03012466
87RUNX2_22187159_ChIP-Seq_PCA_Human1.03011051
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02618530
89KDM2B_26808549_Chip-Seq_DND41_Human1.02421670
90* KDM2B_26808549_Chip-Seq_REH_Human1.02052609
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01791068
92IGF1R_20145208_ChIP-Seq_DFB_Human1.01678897
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01416346
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01394727
95* GATA3_27048872_Chip-Seq_THYMUS_Human1.01297365
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00394868
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99098880
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.97692171
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97531805
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96933315
101KDM2B_26808549_Chip-Seq_K562_Human0.96596453
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96591618
103KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95136598
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.94241974
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92621204
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92354149
107SCL_19346495_ChIP-Seq_HPC-7_Human0.92320700
108RXR_22108803_ChIP-Seq_LS180_Human0.92020307
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91037407
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.90862249
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90761763
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90761763
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90280370
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89876885
115* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89762789
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89120926
117AHR_22903824_ChIP-Seq_MCF-7_Human0.87245792
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86883905
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.86688638
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85116035
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.84139620
122P53_22387025_ChIP-Seq_ESCs_Mouse0.83966637
123BCAT_22108803_ChIP-Seq_LS180_Human0.83800495
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82804520
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82553609
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.82447850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.41489149
2MP0003880_abnormal_central_pattern4.79776245
3* MP0003635_abnormal_synaptic_transmissio4.43734184
4MP0009046_muscle_twitch3.96387905
5* MP0009745_abnormal_behavioral_response3.67773729
6MP0004270_analgesia3.61855071
7MP0002822_catalepsy3.54256474
8* MP0002063_abnormal_learning/memory/cond3.41331411
9MP0002064_seizures3.33658959
10MP0001968_abnormal_touch/_nociception3.21395841
11* MP0002572_abnormal_emotion/affect_behav2.93409282
12MP0002272_abnormal_nervous_system2.92596759
13MP0008569_lethality_at_weaning2.78330450
14MP0002734_abnormal_mechanical_nocicepti2.73611341
15MP0005423_abnormal_somatic_nervous2.68275288
16MP0003763_abnormal_thymus_physiology2.64169172
17MP0001486_abnormal_startle_reflex2.64003929
18MP0002735_abnormal_chemical_nociception2.36907217
19MP0001501_abnormal_sleep_pattern2.33240066
20* MP0002067_abnormal_sensory_capabilities2.31495837
21MP0002736_abnormal_nociception_after2.30997381
22MP0001440_abnormal_grooming_behavior2.18485071
23MP0003879_abnormal_hair_cell2.04721986
24MP0002184_abnormal_innervation2.02858227
25MP0002733_abnormal_thermal_nociception1.99288767
26MP0001188_hyperpigmentation1.89932912
27MP0002557_abnormal_social/conspecific_i1.89637229
28* MP0001970_abnormal_pain_threshold1.89015230
29* MP0004924_abnormal_behavior1.79282572
30* MP0005386_behavior/neurological_phenoty1.79282572
31MP0008877_abnormal_DNA_methylation1.75885032
32MP0005671_abnormal_response_to1.71103072
33MP0004811_abnormal_neuron_physiology1.69563910
34MP0005409_darkened_coat_color1.67732606
35MP0004145_abnormal_muscle_electrophysio1.65084870
36MP0001984_abnormal_olfaction1.63289917
37MP0002909_abnormal_adrenal_gland1.62923992
38MP0009780_abnormal_chondrocyte_physiolo1.62615985
39MP0003329_amyloid_beta_deposits1.55419076
40MP0000778_abnormal_nervous_system1.54476144
41MP0002009_preneoplasia1.50226590
42MP0003633_abnormal_nervous_system1.47219750
43MP0000955_abnormal_spinal_cord1.46610439
44MP0005646_abnormal_pituitary_gland1.46342548
45* MP0002066_abnormal_motor_capabilities/c1.45685546
46MP0001502_abnormal_circadian_rhythm1.42132197
47MP0004142_abnormal_muscle_tone1.38899914
48* MP0002882_abnormal_neuron_morphology1.28407748
49MP0004885_abnormal_endolymph1.25856140
50MP0008872_abnormal_physiological_respon1.25597278
51MP0000703_abnormal_thymus_morphology1.23798814
52MP0003631_nervous_system_phenotype1.21949976
53MP0000569_abnormal_digit_pigmentation1.19528624
54MP0003787_abnormal_imprinting1.19486169
55MP0001529_abnormal_vocalization1.19439388
56MP0004742_abnormal_vestibular_system1.19404169
57MP0004858_abnormal_nervous_system1.18073939
58MP0001800_abnormal_humoral_immune1.17664298
59MP0003866_abnormal_defecation1.17171159
60MP0004130_abnormal_muscle_cell1.14701973
61MP0003122_maternal_imprinting1.10710933
62MP0008874_decreased_physiological_sensi1.09725991
63MP0006276_abnormal_autonomic_nervous1.09616429
64MP0001905_abnormal_dopamine_level1.06854096
65MP0008057_abnormal_DNA_replication1.06760988
66* MP0002152_abnormal_brain_morphology1.04140121
67MP0004381_abnormal_hair_follicle1.04014307
68MP0000015_abnormal_ear_pigmentation1.02457599
69MP0005645_abnormal_hypothalamus_physiol0.97378460
70MP0003121_genomic_imprinting0.94016732
71MP0002229_neurodegeneration0.90446500
72MP0005000_abnormal_immune_tolerance0.89453245
73MP0002398_abnormal_bone_marrow0.89302512
74MP0001986_abnormal_taste_sensitivity0.88823498
75MP0003632_abnormal_nervous_system0.88747092
76MP0002420_abnormal_adaptive_immunity0.85838851
77MP0002069_abnormal_eating/drinking_beha0.85800922
78MP0000920_abnormal_myelination0.83272818
79MP0002876_abnormal_thyroid_physiology0.82861595
80MP0001819_abnormal_immune_cell0.82694198
81MP0001177_atelectasis0.82419028
82MP0005310_abnormal_salivary_gland0.81231780
83MP0005551_abnormal_eye_electrophysiolog0.79825729
84MP0001963_abnormal_hearing_physiology0.79821243
85MP0002723_abnormal_immune_serum0.79384416
86MP0003123_paternal_imprinting0.75891571
87MP0003646_muscle_fatigue0.75639932
88MP0003724_increased_susceptibility_to0.74867647
89MP0000013_abnormal_adipose_tissue0.74772970
90MP0005535_abnormal_body_temperature0.74357885
91MP0000751_myopathy0.73199849
92MP0000631_abnormal_neuroendocrine_gland0.72834315
93MP0003075_altered_response_to0.72431699
94* MP0000716_abnormal_immune_system0.72359018
95MP0004510_myositis0.71859604
96MP0004484_altered_response_of0.71323926
97MP0004085_abnormal_heartbeat0.68431587
98MP0003045_fibrosis0.67566092
99MP0001851_eye_inflammation0.67494196
100MP0004147_increased_porphyrin_level0.67052044
101MP0005394_taste/olfaction_phenotype0.66943689
102MP0005499_abnormal_olfactory_system0.66943689
103MP0002928_abnormal_bile_duct0.64730641
104MP0002163_abnormal_gland_morphology0.64699408
105MP0005174_abnormal_tail_pigmentation0.63657689
106MP0003303_peritoneal_inflammation0.63377800
107MP0000604_amyloidosis0.62992195
108MP0004215_abnormal_myocardial_fiber0.62712616
109MP0002752_abnormal_somatic_nervous0.62493599
110MP0003436_decreased_susceptibility_to0.62441537
111MP0010386_abnormal_urinary_bladder0.61496038
112MP0002638_abnormal_pupillary_reflex0.61455936
113MP0001835_abnormal_antigen_presentation0.61042687
114MP0000685_abnormal_immune_system0.59699310
115MP0002722_abnormal_immune_system0.59362277
116MP0001485_abnormal_pinna_reflex0.57077605
117MP0003690_abnormal_glial_cell0.56861332
118MP0003634_abnormal_glial_cell0.56860377
119MP0010769_abnormal_survival0.56761584
120MP0008961_abnormal_basal_metabolism0.55560432
121MP0010768_mortality/aging0.54112949
122MP0004043_abnormal_pH_regulation0.53386666
123MP0001943_abnormal_respiration0.52685812
124MP0002082_postnatal_lethality0.52475735
125MP0010770_preweaning_lethality0.52475735
126* MP0003956_abnormal_body_size0.51991301
127MP0003137_abnormal_impulse_conducting0.50646369
128MP0001664_abnormal_digestion0.48383249
129MP0005187_abnormal_penis_morphology0.46862841
130MP0002095_abnormal_skin_pigmentation0.44328722
131MP0001348_abnormal_lacrimal_gland0.43758640

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.80950133
2Myokymia (HP:0002411)6.70967980
3Focal seizures (HP:0007359)6.25105665
4Visual hallucinations (HP:0002367)5.66649591
5Progressive cerebellar ataxia (HP:0002073)5.57887119
6Gaze-evoked nystagmus (HP:0000640)5.52722157
7Epileptic encephalopathy (HP:0200134)5.48176420
8Action tremor (HP:0002345)5.30811792
9Atonic seizures (HP:0010819)5.22142067
10Febrile seizures (HP:0002373)5.20171125
11Broad-based gait (HP:0002136)4.97803578
12Absence seizures (HP:0002121)4.49585610
13Dysmetric saccades (HP:0000641)4.33251235
14Poor eye contact (HP:0000817)4.26591639
15Scanning speech (HP:0002168)4.24232309
16Impaired smooth pursuit (HP:0007772)4.11510750
17Dialeptic seizures (HP:0011146)4.07935477
18Hyperventilation (HP:0002883)4.05510139
19Dysdiadochokinesis (HP:0002075)4.00223682
20Annular pancreas (HP:0001734)3.92651609
21Truncal ataxia (HP:0002078)3.78230046
22Generalized tonic-clonic seizures (HP:0002069)3.76759686
23T lymphocytopenia (HP:0005403)3.76627327
24Impaired social interactions (HP:0000735)3.64964458
25Abnormal social behavior (HP:0012433)3.64964458
26Abnormality of ocular smooth pursuit (HP:0000617)3.59463589
27Dysmetria (HP:0001310)3.43625580
28Genetic anticipation (HP:0003743)3.41862019
29Abnormality of T cell number (HP:0011839)3.39057414
30Stereotypic behavior (HP:0000733)3.26584589
31Depression (HP:0000716)3.25823293
32Abnormal eating behavior (HP:0100738)3.17189464
33Hemiplegia (HP:0002301)3.08962058
34Anxiety (HP:0000739)3.05207514
35Severe combined immunodeficiency (HP:0004430)3.02106369
36Impaired vibration sensation in the lower limbs (HP:0002166)2.97999057
37Abnormality of binocular vision (HP:0011514)2.95665959
38Diplopia (HP:0000651)2.95665959
39Hemiparesis (HP:0001269)2.92295106
40Intention tremor (HP:0002080)2.88446319
41Urinary bladder sphincter dysfunction (HP:0002839)2.81692348
42Slow saccadic eye movements (HP:0000514)2.80104735
43Status epilepticus (HP:0002133)2.77256660
44Mutism (HP:0002300)2.74536170
45Ankle clonus (HP:0011448)2.73375719
46Drooling (HP:0002307)2.71162531
47Excessive salivation (HP:0003781)2.71162531
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69664151
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.69664151
50Papilledema (HP:0001085)2.68519248
51Amblyopia (HP:0000646)2.63928537
52Peripheral hypomyelination (HP:0007182)2.59710633
53Fetal akinesia sequence (HP:0001989)2.56369826
54Limb ataxia (HP:0002070)2.53576261
55Spinal canal stenosis (HP:0003416)2.53220753
56Supranuclear gaze palsy (HP:0000605)2.52483137
57Obstructive sleep apnea (HP:0002870)2.51256415
58Horizontal nystagmus (HP:0000666)2.50914114
59Lower limb asymmetry (HP:0100559)2.50026714
60Postural instability (HP:0002172)2.48851580
61Abnormality of saccadic eye movements (HP:0000570)2.48347785
62Epileptiform EEG discharges (HP:0011182)2.45330723
63Protruding tongue (HP:0010808)2.45003505
64Abnormality of the lower motor neuron (HP:0002366)2.44272235
65Torticollis (HP:0000473)2.44165201
66Absent speech (HP:0001344)2.39562483
67Focal dystonia (HP:0004373)2.38407083
68Inability to walk (HP:0002540)2.35064385
69Gait ataxia (HP:0002066)2.34411739
70Amyotrophic lateral sclerosis (HP:0007354)2.34197884
71Progressive inability to walk (HP:0002505)2.33953299
72Impaired vibratory sensation (HP:0002495)2.32897263
73Neurofibrillary tangles (HP:0002185)2.31739290
74Spastic gait (HP:0002064)2.30048950
75Stomatitis (HP:0010280)2.28812532
76Pointed chin (HP:0000307)2.28418077
77Bradykinesia (HP:0002067)2.26892851
78EEG with generalized epileptiform discharges (HP:0011198)2.25956061
79Panhypogammaglobulinemia (HP:0003139)2.24847891
80Cerebral hypomyelination (HP:0006808)2.24175359
81Urinary urgency (HP:0000012)2.23163037
82Lower limb muscle weakness (HP:0007340)2.20232116
83Combined immunodeficiency (HP:0005387)2.20105146
84Inappropriate behavior (HP:0000719)2.17009188
85Thyroiditis (HP:0100646)2.13911591
86Cerebral inclusion bodies (HP:0100314)2.13666666
87Hypsarrhythmia (HP:0002521)2.09966481
88Abnormality of eosinophils (HP:0001879)2.08479176
89Abnormality of the corticospinal tract (HP:0002492)2.08108396
90Iris hypopigmentation (HP:0007730)2.08016531
91Blue irides (HP:0000635)2.06233617
92Craniofacial dystonia (HP:0012179)2.05478881
93Agitation (HP:0000713)2.04806352
94Generalized hypopigmentation of hair (HP:0011358)2.02955785
95Hypoplasia of the thymus (HP:0000778)2.02840405
96Incomplete penetrance (HP:0003829)2.02706401
97Stomach cancer (HP:0012126)2.01827428
98Postural tremor (HP:0002174)2.01016778
99Ocular albinism (HP:0001107)1.97172665
100Abnormality of T cells (HP:0002843)1.94636371
101Limb dystonia (HP:0002451)1.94490411
102Ventricular fibrillation (HP:0001663)1.92952453
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92002336
104Morphological abnormality of the pyramidal tract (HP:0002062)1.90882149
105IgG deficiency (HP:0004315)1.90841101
106Eczematoid dermatitis (HP:0000976)1.90283469
107Tetraplegia (HP:0002445)1.90219030
108Resting tremor (HP:0002322)1.89996666
109Generalized myoclonic seizures (HP:0002123)1.89596684
110Cortical visual impairment (HP:0100704)1.83972400
111Psychosis (HP:0000709)1.81526637
112Nonprogressive disorder (HP:0003680)1.80851990
113Megalencephaly (HP:0001355)1.80756191
114Sleep apnea (HP:0010535)1.79970959
115Memory impairment (HP:0002354)1.78474656
116Fair hair (HP:0002286)1.77169351
117Akinesia (HP:0002304)1.76798263
118Delusions (HP:0000746)1.76378126
119Dyskinesia (HP:0100660)1.76357638
120Abnormality of salivation (HP:0100755)1.74527046
121Recurrent fungal infections (HP:0002841)1.71144237
122Menstrual irregularities (HP:0000858)1.69447662
123Deeply set eye (HP:0000490)1.68796074
124Progressive microcephaly (HP:0000253)1.68753485
125Clonus (HP:0002169)1.67031079
126Polyphagia (HP:0002591)1.64022450
127Neuronal loss in central nervous system (HP:0002529)1.63855272
128Intellectual disability, severe (HP:0010864)1.60863850
129Termporal pattern (HP:0011008)1.60173848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.48400038
2NTRK34.18579216
3CASK3.32919646
4MAP3K93.11304274
5TNIK3.08782746
6DAPK23.04342899
7MAP2K73.01861137
8MAP3K42.90062094
9MARK12.82209805
10RIPK42.81317770
11CDK192.72392573
12MINK12.56155854
13NTRK22.11584987
14PRPF4B2.09463730
15MAP3K122.08651884
16DAPK12.01831540
17PAK61.86391920
18MAP2K41.85617631
19MAP4K11.76811047
20FES1.62732830
21MAP3K101.55144258
22KSR11.48398253
23CDK51.48392498
24KSR21.46974734
25PLK21.46040426
26SIK21.45458973
27MAPK131.36690167
28STK381.35889512
29ITK1.35311977
30CCNB11.27449123
31NTRK11.27035390
32PRKCG1.25875225
33JAK11.22503924
34GRK51.19087877
35SGK21.18840201
36NLK1.15680698
37BMPR21.15077051
38* CAMKK11.10347255
39PAK31.10294348
40BRD41.06570888
41RIPK11.05130685
42STK111.02581575
43SGK2231.00170221
44SGK4941.00170221
45PRKD31.00023097
46OXSR10.99498780
47IKBKE0.96538452
48MAP3K130.95017923
49SGK30.93812342
50CDK180.93656168
51TAOK10.93406924
52ARAF0.90203621
53UHMK10.89762973
54CDK150.89675292
55SIK30.89577935
56GRK60.88789995
57CAMK2B0.88444199
58PRKCH0.87466615
59TYRO30.85702518
60LCK0.84902526
61PRKCQ0.83169012
62CDK140.82195127
63* CAMK2A0.81991525
64RAF10.81054993
65MAP3K20.80467246
66CDK11A0.80360707
67PNCK0.79029437
68PDK10.77421038
69FGFR30.77208694
70WNK10.75358953
71SGK10.74955561
72BTK0.74770777
73FGFR20.74245437
74DYRK1A0.73648632
75MARK20.72983917
76JAK20.72135382
77HCK0.70714735
78PASK0.70566289
79* CAMK10.70250277
80RET0.69856896
81PINK10.67894511
82TNK20.67313001
83MUSK0.67114736
84EPHA30.66109406
85MAPK120.61901009
86* CAMK40.61887528
87CSNK1G20.61619795
88PDPK10.60824335
89PTK2B0.58085899
90MAP3K10.57308505
91FYN0.57081772
92TAOK30.56975922
93PHKG20.56893118
94PHKG10.56893118
95TXK0.54405238
96HIPK20.53652709
97ZAP700.53638951
98MAPK70.53025889
99DYRK1B0.50681729
100ALK0.49754773
101NEK60.48625022
102EIF2AK30.48624539
103CAMK2G0.47630560
104SCYL20.47437221
105RPS6KA30.47054411
106YES10.45660698
107IRAK20.44753786
108TEC0.44272635
109AKT30.43893953
110PKN10.42586737
111DAPK30.41586510
112FRK0.41317436
113CAMK2D0.40413272
114TYK20.40184007
115MAP3K60.39034185
116LYN0.39025450
117PRKCE0.38885609
118CDK30.38251272
119PRKG10.36440636
120PRKCZ0.34732417
121MAPK100.34039516
122SYK0.33959847
123PRKCB0.32483600
124MAP3K70.32263322
125PRKACA0.30274360
126PRKCA0.29727612
127CDC42BPA0.27662788
128CSNK1A10.24968544
129TAOK20.24355910
130MAPK80.23534512

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17745419
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11931297
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94490754
4Glutamatergic synapse_Homo sapiens_hsa047242.94093628
5* Long-term potentiation_Homo sapiens_hsa047202.92289576
6Circadian entrainment_Homo sapiens_hsa047132.90770505
7Morphine addiction_Homo sapiens_hsa050322.81377293
8Olfactory transduction_Homo sapiens_hsa047402.74633793
9GABAergic synapse_Homo sapiens_hsa047272.70557598
10* Amphetamine addiction_Homo sapiens_hsa050312.46480051
11Salivary secretion_Homo sapiens_hsa049702.35258156
12Dopaminergic synapse_Homo sapiens_hsa047282.24198735
13Long-term depression_Homo sapiens_hsa047302.16253678
14Taste transduction_Homo sapiens_hsa047422.03330018
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95378107
16Gastric acid secretion_Homo sapiens_hsa049711.92600539
17Insulin secretion_Homo sapiens_hsa049111.90477807
18* Cholinergic synapse_Homo sapiens_hsa047251.89834047
19* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89320156
20Renin secretion_Homo sapiens_hsa049241.80438743
21Primary immunodeficiency_Homo sapiens_hsa053401.75285372
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.66887771
23* Calcium signaling pathway_Homo sapiens_hsa040201.64716864
24Serotonergic synapse_Homo sapiens_hsa047261.63957812
25Cocaine addiction_Homo sapiens_hsa050301.63048279
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58568976
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45203222
28GnRH signaling pathway_Homo sapiens_hsa049121.43885073
29Gap junction_Homo sapiens_hsa045401.42345572
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40634724
31* cAMP signaling pathway_Homo sapiens_hsa040241.31260979
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25717075
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21175727
34B cell receptor signaling pathway_Homo sapiens_hsa046621.18684646
35Type II diabetes mellitus_Homo sapiens_hsa049301.17849106
36Collecting duct acid secretion_Homo sapiens_hsa049661.16625661
37Estrogen signaling pathway_Homo sapiens_hsa049151.12112217
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10980810
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10585388
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10468322
41Pancreatic secretion_Homo sapiens_hsa049721.01044075
42Melanogenesis_Homo sapiens_hsa049160.97077946
43Glioma_Homo sapiens_hsa052140.96520231
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96318717
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95813722
46ErbB signaling pathway_Homo sapiens_hsa040120.93804629
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.91681416
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91669480
49Thyroid hormone synthesis_Homo sapiens_hsa049180.88219887
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84729854
51Axon guidance_Homo sapiens_hsa043600.84688000
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.84588530
53Oocyte meiosis_Homo sapiens_hsa041140.84575605
54Circadian rhythm_Homo sapiens_hsa047100.82703263
55Phototransduction_Homo sapiens_hsa047440.80475062
56Renal cell carcinoma_Homo sapiens_hsa052110.77626162
57Acute myeloid leukemia_Homo sapiens_hsa052210.76179823
58Measles_Homo sapiens_hsa051620.74388577
59Cardiac muscle contraction_Homo sapiens_hsa042600.73943481
60FoxO signaling pathway_Homo sapiens_hsa040680.73696998
61* Osteoclast differentiation_Homo sapiens_hsa043800.73546667
62MAPK signaling pathway_Homo sapiens_hsa040100.73501128
63Choline metabolism in cancer_Homo sapiens_hsa052310.69619770
64Inositol phosphate metabolism_Homo sapiens_hsa005620.67623107
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65845356
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64538373
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64179899
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62469395
69VEGF signaling pathway_Homo sapiens_hsa043700.59654332
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58358113
71* Neurotrophin signaling pathway_Homo sapiens_hsa047220.58206205
72Vibrio cholerae infection_Homo sapiens_hsa051100.57816804
73Dorso-ventral axis formation_Homo sapiens_hsa043200.56031650
74Chemokine signaling pathway_Homo sapiens_hsa040620.55911374
75T cell receptor signaling pathway_Homo sapiens_hsa046600.55696903
76Hepatitis B_Homo sapiens_hsa051610.55643610
77Dilated cardiomyopathy_Homo sapiens_hsa054140.55429585
78Regulation of autophagy_Homo sapiens_hsa041400.54793675
79Pancreatic cancer_Homo sapiens_hsa052120.54456806
80Type I diabetes mellitus_Homo sapiens_hsa049400.53498832
81Rap1 signaling pathway_Homo sapiens_hsa040150.53419111
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.52527996
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51618847
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.51358410
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51331006
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50672473
87Chronic myeloid leukemia_Homo sapiens_hsa052200.50571358
88African trypanosomiasis_Homo sapiens_hsa051430.49745583
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49032050
90Non-small cell lung cancer_Homo sapiens_hsa052230.48841208
91Ras signaling pathway_Homo sapiens_hsa040140.48323850
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47127926
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.46692091
94Endometrial cancer_Homo sapiens_hsa052130.46553700
95* Alcoholism_Homo sapiens_hsa050340.45088900
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44756324
97Glucagon signaling pathway_Homo sapiens_hsa049220.42910498
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42446077
99mTOR signaling pathway_Homo sapiens_hsa041500.42062023
100Wnt signaling pathway_Homo sapiens_hsa043100.40219328
101Platelet activation_Homo sapiens_hsa046110.39925385
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39823608
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38476324
104Autoimmune thyroid disease_Homo sapiens_hsa053200.37722540
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36073190
106Endocytosis_Homo sapiens_hsa041440.33926919
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32777075
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32429546
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32098152
110Colorectal cancer_Homo sapiens_hsa052100.31931456
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30160860
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29123887
113* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28044620
114Bile secretion_Homo sapiens_hsa049760.27280511
115Ovarian steroidogenesis_Homo sapiens_hsa049130.24342695
116Insulin signaling pathway_Homo sapiens_hsa049100.24220596
117Prolactin signaling pathway_Homo sapiens_hsa049170.21705319

Most similar genes based on co-expression Upload to Enrichr

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