CAMKK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.60405451
2synaptic vesicle maturation (GO:0016188)6.31427766
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.03114373
4locomotory exploration behavior (GO:0035641)5.89746301
5synaptic vesicle exocytosis (GO:0016079)5.71677620
6glutamate secretion (GO:0014047)5.51376169
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41849174
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39560688
9vocalization behavior (GO:0071625)5.31407258
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.23993026
11regulation of glutamate receptor signaling pathway (GO:1900449)5.17707900
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.15196184
13regulation of synaptic vesicle exocytosis (GO:2000300)5.03127626
14protein localization to synapse (GO:0035418)4.98075257
15regulation of neuronal synaptic plasticity (GO:0048168)4.95012152
16regulation of synapse structural plasticity (GO:0051823)4.77631148
17cerebellar granule cell differentiation (GO:0021707)4.69985985
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.67515791
19glutamate receptor signaling pathway (GO:0007215)4.60326392
20exploration behavior (GO:0035640)4.58947076
21regulation of synaptic vesicle transport (GO:1902803)4.56473205
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.51976469
23synaptic transmission, glutamatergic (GO:0035249)4.51617398
24neuronal action potential propagation (GO:0019227)4.51458570
25neurotransmitter secretion (GO:0007269)4.43832442
26cellular potassium ion homeostasis (GO:0030007)4.38490576
27long-term memory (GO:0007616)4.35124224
28neurotransmitter-gated ion channel clustering (GO:0072578)4.28411993
29amino acid import (GO:0043090)4.24474172
30negative regulation of dendrite morphogenesis (GO:0050774)4.24048719
31positive regulation of synapse maturation (GO:0090129)4.20287101
32neuron-neuron synaptic transmission (GO:0007270)4.19554180
33sodium ion export (GO:0071436)4.18003142
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13465264
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.12043752
36regulation of synaptic plasticity (GO:0048167)4.04106222
37positive regulation of membrane potential (GO:0045838)4.02738612
38potassium ion homeostasis (GO:0055075)3.99433073
39regulation of dendritic spine morphogenesis (GO:0061001)3.93543386
40potassium ion import (GO:0010107)3.93416817
41layer formation in cerebral cortex (GO:0021819)3.92923994
42regulation of postsynaptic membrane potential (GO:0060078)3.88365434
43regulation of voltage-gated calcium channel activity (GO:1901385)3.84002319
44dendritic spine morphogenesis (GO:0060997)3.83060894
45neuron cell-cell adhesion (GO:0007158)3.82234006
46proline transport (GO:0015824)3.79405072
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.77179393
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.76919496
49long-term synaptic potentiation (GO:0060291)3.72438586
50synaptic vesicle endocytosis (GO:0048488)3.65805107
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.63747310
52neurotransmitter transport (GO:0006836)3.63674407
53activation of protein kinase A activity (GO:0034199)3.62015114
54vesicle docking involved in exocytosis (GO:0006904)3.61970499
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.61565645
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.60657154
57cell communication by electrical coupling (GO:0010644)3.60236357
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.56522438
59neuromuscular process controlling balance (GO:0050885)3.54821181
60gamma-aminobutyric acid transport (GO:0015812)3.54097539
61transmission of nerve impulse (GO:0019226)3.54064999
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.53768322
63regulation of vesicle fusion (GO:0031338)3.53589864
64behavioral fear response (GO:0001662)3.49218951
65behavioral defense response (GO:0002209)3.49218951
66regulation of exocytosis (GO:0017157)3.48031098
67regulation of neurotransmitter secretion (GO:0046928)3.46976417
68positive regulation of dendritic spine development (GO:0060999)3.45696994
69neuromuscular process controlling posture (GO:0050884)3.42940183
70neuron recognition (GO:0008038)3.35437263
71cerebellar Purkinje cell differentiation (GO:0021702)3.32581166
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32089012
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31990923
74regulation of neurotransmitter levels (GO:0001505)3.31927741
75detection of calcium ion (GO:0005513)3.31339709
76positive regulation of neurotransmitter secretion (GO:0001956)3.31110537
77membrane depolarization (GO:0051899)3.28958213
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27722081
79regulation of dendritic spine development (GO:0060998)3.26105742
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24949373
81innervation (GO:0060384)3.23312703
82positive regulation of neurotransmitter transport (GO:0051590)3.23296568
83membrane depolarization during action potential (GO:0086010)3.23164734
84dendritic spine organization (GO:0097061)3.23010415
85regulation of neurotransmitter transport (GO:0051588)3.21948680
86fear response (GO:0042596)3.21546225
87regulation of synaptic transmission (GO:0050804)3.20789865
88cell differentiation in hindbrain (GO:0021533)3.20716500
89long term synaptic depression (GO:0060292)3.20393656
90regulation of synapse maturation (GO:0090128)3.20346420
91vesicle docking (GO:0048278)3.19874432
92cellular sodium ion homeostasis (GO:0006883)3.19664773
93axon ensheathment in central nervous system (GO:0032291)3.18519344
94central nervous system myelination (GO:0022010)3.18519344
95learning (GO:0007612)3.17759824
96regulation of ARF protein signal transduction (GO:0032012)3.17410647
97postsynaptic membrane organization (GO:0001941)3.15976459
98L-amino acid import (GO:0043092)3.15870501
99glycine transport (GO:0015816)3.15842644
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15152060
101positive regulation of fibroblast migration (GO:0010763)3.14596352
102positive regulation of synaptic transmission (GO:0050806)3.13656580
103response to histamine (GO:0034776)3.10185270
104signal release (GO:0023061)3.09662590
105axonal fasciculation (GO:0007413)3.09640330
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09442439
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07998728
108* synaptic transmission (GO:0007268)3.07973202
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07492258
110cytoskeletal anchoring at plasma membrane (GO:0007016)3.07464313
111prepulse inhibition (GO:0060134)3.06711485
112establishment of synaptic vesicle localization (GO:0097480)3.06533540
113synaptic vesicle transport (GO:0048489)3.06533540
114membrane hyperpolarization (GO:0060081)3.05680614
115dendrite morphogenesis (GO:0048813)3.04038506
116acidic amino acid transport (GO:0015800)3.03015598
117neuronal ion channel clustering (GO:0045161)3.00899146
118response to auditory stimulus (GO:0010996)3.00364468
119positive regulation of exocytosis (GO:0045921)2.98526125
120auditory behavior (GO:0031223)2.97642694
121establishment of nucleus localization (GO:0040023)2.97427891
122phosphorelay signal transduction system (GO:0000160)2.93958755
123neuromuscular process (GO:0050905)2.92879190
124neurotransmitter uptake (GO:0001504)2.91043034
125cell migration in hindbrain (GO:0021535)2.90382103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.44602126
2GBX2_23144817_ChIP-Seq_PC3_Human3.24939516
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21026329
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20361522
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19967023
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.97890310
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.87598910
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86121211
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86121211
10REST_21632747_ChIP-Seq_MESCs_Mouse2.84402706
11DROSHA_22980978_ChIP-Seq_HELA_Human2.74677980
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70922884
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.69758549
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66142734
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65689017
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62669508
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.53481788
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46899161
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45277002
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.42638540
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.39052777
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.34827180
23* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27771170
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23562488
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18125970
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15282821
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01651895
28LXR_22292898_ChIP-Seq_THP-1_Human1.87414282
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69167671
30AR_21572438_ChIP-Seq_LNCaP_Human1.68266533
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.60865271
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58200081
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51217235
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48935788
35SMAD4_21799915_ChIP-Seq_A2780_Human1.47973881
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.46084881
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45238227
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44576647
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39721483
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37929493
41* KDM2B_26808549_Chip-Seq_DND41_Human1.36403028
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34526816
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.34234358
44* SMC4_20622854_ChIP-Seq_HELA_Human1.32622777
45KDM2B_26808549_Chip-Seq_K562_Human1.26265270
46P68_20966046_ChIP-Seq_HELA_Human1.24486747
47AR_19668381_ChIP-Seq_PC3_Human1.24317886
48TAF15_26573619_Chip-Seq_HEK293_Human1.24056902
49OCT4_19829295_ChIP-Seq_ESCs_Human1.23578377
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23058423
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22421859
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22209564
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22096390
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.21366984
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21308114
56ZNF274_21170338_ChIP-Seq_K562_Hela1.21104398
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20300075
58AR_25329375_ChIP-Seq_VCAP_Human1.19568609
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18753350
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.18117470
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17714736
62* CREB1_26743006_Chip-Seq_LNCaP_Human1.16974568
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16228001
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.15984275
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14931312
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14360008
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13626606
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12101182
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11529865
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.11422613
71P300_19829295_ChIP-Seq_ESCs_Human1.11213278
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.10965031
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.09753816
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08946208
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08888192
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05983859
77* STAT3_23295773_ChIP-Seq_U87_Human1.05714317
78KLF4_19829295_ChIP-Seq_ESCs_Human1.05688670
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05446767
80CTCF_27219007_Chip-Seq_Bcells_Human1.05086669
81DPY_21335234_ChIP-Seq_ESCs_Mouse1.04689445
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03993403
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03404470
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02159862
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00839552
86TCF7_22412390_ChIP-Seq_EML_Mouse1.00479966
87BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98188531
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.97563999
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97311898
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97234835
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96919912
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95438515
93SMAD4_21741376_ChIP-Seq_ESCs_Human0.95422096
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.94816578
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94641158
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94444913
97* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94139835
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93874024
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92937674
100RNF2_27304074_Chip-Seq_NSC_Mouse0.92089549
101TET1_21490601_ChIP-Seq_MESCs_Mouse0.91406177
102* TCF4_23295773_ChIP-Seq_U87_Human0.91369932
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91010475
104* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88752653
105IGF1R_20145208_ChIP-Seq_DFB_Human0.88709450
106* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88501026
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.88091824
108ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88080745
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.87903680
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87718595
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87397161
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87007726
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.86327649
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.84874935
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84785082
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.84509336
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84062435
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.83973456
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.83926895
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83380053
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.83066364
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82171652
123* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81894328
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80494201
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79690595
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79380681
127TP53_16413492_ChIP-PET_HCT116_Human0.79345392
128AHR_22903824_ChIP-Seq_MCF-7_Human0.77629705
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77575346
130SA1_27219007_Chip-Seq_Bcells_Human0.77213002
131RUNX2_22187159_ChIP-Seq_PCA_Human0.77211116
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77156654
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77021093
134MYC_19915707_ChIP-ChIP_AK7_Human0.74691396
135* TP53_23651856_ChIP-Seq_MEFs_Mouse0.74237820
136* RACK7_27058665_Chip-Seq_MCF-7_Human0.73404620
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72882427
138* MITF_21258399_ChIP-Seq_MELANOMA_Human0.72330758
139FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72192745
140EGR1_19032775_ChIP-ChIP_M12_Human0.72020980
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71824040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.74985027
2MP0003880_abnormal_central_pattern5.17310755
3MP0003635_abnormal_synaptic_transmissio4.48133738
4MP0009745_abnormal_behavioral_response3.62116955
5* MP0002063_abnormal_learning/memory/cond3.53593632
6MP0004270_analgesia3.46222419
7MP0002064_seizures3.31575715
8MP0009046_muscle_twitch2.97581699
9MP0001968_abnormal_touch/_nociception2.95898319
10MP0002822_catalepsy2.95795594
11MP0002572_abnormal_emotion/affect_behav2.85039976
12MP0002272_abnormal_nervous_system2.71350448
13MP0001486_abnormal_startle_reflex2.60127605
14MP0001501_abnormal_sleep_pattern2.51839775
15MP0005423_abnormal_somatic_nervous2.50248807
16MP0002736_abnormal_nociception_after2.42547664
17MP0002734_abnormal_mechanical_nocicepti2.33911410
18MP0002735_abnormal_chemical_nociception2.32271366
19MP0001440_abnormal_grooming_behavior2.14168853
20MP0008569_lethality_at_weaning2.07474051
21MP0002067_abnormal_sensory_capabilities1.90648035
22MP0001970_abnormal_pain_threshold1.88359714
23MP0002733_abnormal_thermal_nociception1.85597024
24MP0004858_abnormal_nervous_system1.85312138
25MP0003123_paternal_imprinting1.81053682
26MP0004811_abnormal_neuron_physiology1.80154318
27MP0003329_amyloid_beta_deposits1.77194644
28MP0002909_abnormal_adrenal_gland1.73969501
29MP0002184_abnormal_innervation1.71230997
30MP0002557_abnormal_social/conspecific_i1.66800108
31MP0003879_abnormal_hair_cell1.65737308
32MP0009780_abnormal_chondrocyte_physiolo1.60714819
33MP0000955_abnormal_spinal_cord1.59356217
34MP0005646_abnormal_pituitary_gland1.58087076
35MP0004924_abnormal_behavior1.51706451
36MP0005386_behavior/neurological_phenoty1.51706451
37MP0000778_abnormal_nervous_system1.50724552
38MP0001502_abnormal_circadian_rhythm1.47945601
39MP0002882_abnormal_neuron_morphology1.43112647
40MP0003787_abnormal_imprinting1.42267146
41MP0004885_abnormal_endolymph1.39212208
42MP0002066_abnormal_motor_capabilities/c1.38873998
43MP0001348_abnormal_lacrimal_gland1.35447724
44MP0003633_abnormal_nervous_system1.33744832
45MP0006276_abnormal_autonomic_nervous1.33276969
46MP0003075_altered_response_to1.31609193
47MP0004142_abnormal_muscle_tone1.30931987
48MP0001984_abnormal_olfaction1.30498628
49MP0005551_abnormal_eye_electrophysiolog1.22608367
50MP0005645_abnormal_hypothalamus_physiol1.10396019
51MP0001986_abnormal_taste_sensitivity1.10161338
52MP0000751_myopathy1.09119573
53MP0003631_nervous_system_phenotype1.08750760
54MP0002152_abnormal_brain_morphology1.03946990
55MP0001905_abnormal_dopamine_level1.03382849
56MP0001177_atelectasis1.03089560
57MP0002090_abnormal_vision1.02351254
58MP0003122_maternal_imprinting1.01347121
59MP0008872_abnormal_physiological_respon0.99286391
60MP0002229_neurodegeneration0.97541979
61MP0008874_decreased_physiological_sensi0.96565368
62MP0002069_abnormal_eating/drinking_beha0.94257255
63MP0010234_abnormal_vibrissa_follicle0.92522539
64MP0001188_hyperpigmentation0.91912192
65MP0010386_abnormal_urinary_bladder0.91006457
66MP0003283_abnormal_digestive_organ0.90643511
67MP0001529_abnormal_vocalization0.90473369
68MP0003121_genomic_imprinting0.88758379
69MP0008961_abnormal_basal_metabolism0.87461220
70MP0004510_myositis0.85917146
71MP0004085_abnormal_heartbeat0.85739605
72MP0002234_abnormal_pharynx_morphology0.84324429
73MP0005535_abnormal_body_temperature0.81078045
74MP0003690_abnormal_glial_cell0.80491288
75MP0005167_abnormal_blood-brain_barrier0.79931349
76MP0000013_abnormal_adipose_tissue0.77350068
77MP0001963_abnormal_hearing_physiology0.75635523
78MP0003045_fibrosis0.75573865
79MP0004130_abnormal_muscle_cell0.75504280
80MP0004145_abnormal_muscle_electrophysio0.74605325
81MP0003634_abnormal_glial_cell0.74588193
82MP0006292_abnormal_olfactory_placode0.73953744
83MP0002752_abnormal_somatic_nervous0.73891160
84MP0001664_abnormal_digestion0.73343076
85MP0000604_amyloidosis0.71830482
86MP0004233_abnormal_muscle_weight0.70561635
87MP0004147_increased_porphyrin_level0.68976186
88MP0004215_abnormal_myocardial_fiber0.68909899
89MP0003632_abnormal_nervous_system0.68136614
90MP0008877_abnormal_DNA_methylation0.67113802
91MP0004742_abnormal_vestibular_system0.65585003
92MP0003137_abnormal_impulse_conducting0.65537663
93MP0000920_abnormal_myelination0.64932412
94MP0006072_abnormal_retinal_apoptosis0.64641429
95MP0000631_abnormal_neuroendocrine_gland0.64264874
96MP0005394_taste/olfaction_phenotype0.63878901
97MP0005499_abnormal_olfactory_system0.63878901
98MP0005409_darkened_coat_color0.63337062
99MP0001346_abnormal_lacrimal_gland0.61886815
100MP0004484_altered_response_of0.61063124
101MP0005623_abnormal_meninges_morphology0.60732259
102MP0008260_abnormal_autophagy0.60641955
103MP0001485_abnormal_pinna_reflex0.59966453
104MP0001765_abnormal_ion_homeostasis0.58783167
105MP0000569_abnormal_digit_pigmentation0.55845725
106MP0005166_decreased_susceptibility_to0.55654939
107MP0010769_abnormal_survival0.52821007
108MP0002638_abnormal_pupillary_reflex0.52063932
109MP0003172_abnormal_lysosome_physiology0.51209688
110MP0001943_abnormal_respiration0.51136414
111MP0000747_muscle_weakness0.50646304
112MP0003956_abnormal_body_size0.49874253
113MP0003303_peritoneal_inflammation0.46750955
114MP0000681_abnormal_thyroid_gland0.45959382
115MP0003183_abnormal_peptide_metabolism0.45172211
116MP0010768_mortality/aging0.44716247
117MP0002083_premature_death0.44307875
118MP0000639_abnormal_adrenal_gland0.44191943

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.10085225
2Myokymia (HP:0002411)7.84215539
3Focal seizures (HP:0007359)5.98922401
4Visual hallucinations (HP:0002367)5.69013602
5Epileptic encephalopathy (HP:0200134)4.97910625
6Febrile seizures (HP:0002373)4.86155326
7Atonic seizures (HP:0010819)4.84507124
8Absence seizures (HP:0002121)4.53557388
9Progressive cerebellar ataxia (HP:0002073)4.45165839
10Dialeptic seizures (HP:0011146)4.16423651
11Action tremor (HP:0002345)4.07514989
12Generalized tonic-clonic seizures (HP:0002069)4.04648855
13Abnormality of the lower motor neuron (HP:0002366)3.88108797
14Supranuclear gaze palsy (HP:0000605)3.86746799
15Obstructive sleep apnea (HP:0002870)3.83709178
16Depression (HP:0000716)3.57121085
17Impaired vibration sensation in the lower limbs (HP:0002166)3.47542787
18Ankle clonus (HP:0011448)3.45705823
19Dysdiadochokinesis (HP:0002075)3.43088537
20Gaze-evoked nystagmus (HP:0000640)3.31420588
21Poor eye contact (HP:0000817)3.30893156
22Dysmetria (HP:0001310)3.28957389
23Tetraplegia (HP:0002445)3.26346957
24Postural instability (HP:0002172)3.26149751
25Broad-based gait (HP:0002136)3.17963450
26Ventricular fibrillation (HP:0001663)3.16090587
27Cerebral hypomyelination (HP:0006808)3.13013049
28Impaired smooth pursuit (HP:0007772)3.10757765
29Anxiety (HP:0000739)3.10698139
30Truncal ataxia (HP:0002078)3.07843928
31Akinesia (HP:0002304)2.99556789
32Urinary bladder sphincter dysfunction (HP:0002839)2.97337992
33Mutism (HP:0002300)2.97216345
34Abnormal social behavior (HP:0012433)2.96904363
35Impaired social interactions (HP:0000735)2.96904363
36Abnormal eating behavior (HP:0100738)2.93399088
37Amblyopia (HP:0000646)2.89321269
38Annular pancreas (HP:0001734)2.82861405
39Papilledema (HP:0001085)2.81418461
40Scanning speech (HP:0002168)2.79109160
41Hemiplegia (HP:0002301)2.74770759
42Torticollis (HP:0000473)2.74094508
43Apathy (HP:0000741)2.72548197
44Hemiparesis (HP:0001269)2.69415337
45Genetic anticipation (HP:0003743)2.69380487
46Urinary urgency (HP:0000012)2.65320788
47Stereotypic behavior (HP:0000733)2.63923944
48Bradykinesia (HP:0002067)2.63754043
49Sleep apnea (HP:0010535)2.62688422
50Abnormality of ocular smooth pursuit (HP:0000617)2.62470357
51Limb dystonia (HP:0002451)2.61002474
52Status epilepticus (HP:0002133)2.59440466
53Polyphagia (HP:0002591)2.54796068
54Hyperventilation (HP:0002883)2.54603550
55Pointed chin (HP:0000307)2.54257201
56Focal dystonia (HP:0004373)2.52786677
57Diminished motivation (HP:0000745)2.49299964
58Intention tremor (HP:0002080)2.48930975
59Spastic gait (HP:0002064)2.44938553
60Dysmetric saccades (HP:0000641)2.42883640
61Drooling (HP:0002307)2.34862050
62Excessive salivation (HP:0003781)2.34862050
63Epileptiform EEG discharges (HP:0011182)2.31175051
64Insomnia (HP:0100785)2.30555624
65Spastic tetraparesis (HP:0001285)2.30356142
66Impaired vibratory sensation (HP:0002495)2.30004498
67Abnormality of binocular vision (HP:0011514)2.26699783
68Diplopia (HP:0000651)2.26699783
69Generalized myoclonic seizures (HP:0002123)2.20846404
70Peripheral hypomyelination (HP:0007182)2.20523761
71Craniofacial dystonia (HP:0012179)2.17660725
72Ankyloglossia (HP:0010296)2.17314468
73Fetal akinesia sequence (HP:0001989)2.16822320
74Iris hypopigmentation (HP:0007730)2.16591639
75Cerebral inclusion bodies (HP:0100314)2.15690396
76Choreoathetosis (HP:0001266)2.15676465
77Progressive inability to walk (HP:0002505)2.14426800
78Incomplete penetrance (HP:0003829)2.12029957
79Megalencephaly (HP:0001355)2.11936670
80EEG with generalized epileptiform discharges (HP:0011198)2.11361107
81Slow saccadic eye movements (HP:0000514)2.09214312
82Neurofibrillary tangles (HP:0002185)2.07514413
83Abnormality of the corticospinal tract (HP:0002492)2.04732782
84Ocular albinism (HP:0001107)2.04293063
85Memory impairment (HP:0002354)2.04021977
86Abnormal EKG (HP:0003115)2.02816077
87Lower limb muscle weakness (HP:0007340)2.02249310
88Rapidly progressive (HP:0003678)2.01394381
89Global brain atrophy (HP:0002283)2.00433387
90Retinal dysplasia (HP:0007973)2.00249256
91Bundle branch block (HP:0011710)1.99149927
92Absent speech (HP:0001344)1.98801257
93CNS hypomyelination (HP:0003429)1.98616229
94Delusions (HP:0000746)1.97731344
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97259235
96Spinal canal stenosis (HP:0003416)1.96552196
97Abnormality of saccadic eye movements (HP:0000570)1.96154755
98Increased circulating renin level (HP:0000848)1.95117363
99Hypsarrhythmia (HP:0002521)1.93443693
100Rigidity (HP:0002063)1.91951233
101Dementia (HP:0000726)1.90031088
102Gait ataxia (HP:0002066)1.87703814
103Central scotoma (HP:0000603)1.86982702
104Abnormality of the periventricular white matter (HP:0002518)1.86149567
105Clonus (HP:0002169)1.85284938
106Resting tremor (HP:0002322)1.84279623
107Limb ataxia (HP:0002070)1.83923009
108Failure to thrive in infancy (HP:0001531)1.83138936
109Lower limb amyotrophy (HP:0007210)1.82139753
110Anosmia (HP:0000458)1.80673971
111Lower limb asymmetry (HP:0100559)1.78807296
112Hypoventilation (HP:0002791)1.78635996
113Congenital stationary night blindness (HP:0007642)1.78456142
114Inability to walk (HP:0002540)1.77208203
115Type II lissencephaly (HP:0007260)1.76674886
116Deep palmar crease (HP:0006191)1.75148059
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74392339
118Neuronal loss in central nervous system (HP:0002529)1.74226924
119Psychosis (HP:0000709)1.73078330
120Protruding tongue (HP:0010808)1.70315168
121Insidious onset (HP:0003587)1.70309186
122Termporal pattern (HP:0011008)1.70309186
123Neoplasm of the heart (HP:0100544)1.70294372
124Thickened helices (HP:0000391)1.66012269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.50532373
2NTRK34.96912056
3MAP3K94.08902922
4MINK12.72144052
5KSR22.56199178
6DAPK22.52850317
7MAP3K42.50739368
8PRKD32.29934333
9PAK62.25028903
10MAP3K132.06426455
11CAMKK12.00490281
12MAP2K71.99372842
13RIPK41.98977420
14MARK11.96700608
15NTRK21.94936010
16PRPF4B1.94366296
17ARAF1.92900425
18TNIK1.87629563
19KSR11.70498186
20DAPK11.67794769
21FES1.58500769
22MAP3K121.58252120
23STK381.55808538
24MAP2K41.55745895
25CDK51.54929234
26NTRK11.48568925
27CDK191.44715889
28CASK1.43231046
29GRK51.26859009
30MAP3K21.21734012
31SIK21.19138963
32PLK21.18571435
33PRKCG1.15927152
34PINK11.09218539
35RAF11.08517350
36MAP3K111.07509245
37MAPK131.07226381
38MAP3K71.04590387
39TAOK11.04358226
40PTK2B1.03030059
41CAMKK21.01235453
42MARK20.99256907
43TYRO30.98889763
44UHMK10.96870221
45LMTK20.95449483
46* CAMK10.94619088
47CAMK2A0.94003866
48PRKCH0.91788100
49TNK20.91324458
50CAMK2B0.86084004
51CDK180.83736389
52CDK150.83115239
53MAP3K10.80939163
54PDK10.80401235
55NME10.79909650
56MAP2K60.79694655
57STK110.77658566
58CDK140.77368195
59RET0.77190235
60ALK0.74218138
61SGK2230.73973110
62SGK4940.73973110
63CDK11A0.73682283
64PHKG10.72581570
65PHKG20.72581570
66WNK10.69607600
67CAMK1D0.68013904
68PDPK10.66908774
69DYRK1A0.66679363
70TAOK20.65807626
71TRIB30.65134725
72RIPK10.64674345
73IRAK20.61968663
74PNCK0.61853860
75SGK10.60325994
76PRKG20.56866480
77FER0.56750173
78BMPR20.56098103
79SGK30.53714053
80MOS0.53008237
81SGK20.52839688
82BRSK10.52616937
83PRKD20.52140755
84CAMK40.51849581
85NEK10.50940082
86LATS20.50503852
87PAK30.50401788
88JAK20.49592447
89DMPK0.48644032
90RPS6KA30.47368822
91CAMK2D0.47357371
92BRAF0.46830191
93CAMK2G0.45195619
94MAP2K10.44630404
95MAPK100.43342717
96MUSK0.42189409
97NEK60.42137763
98FYN0.41807492
99CDC42BPA0.40931663
100PKN10.40156570
101EEF2K0.38106559
102DAPK30.37983369
103PRKCZ0.37625325
104CSNK1G20.37324871
105OXSR10.34606204
106PRKCE0.34314081
107RPS6KA20.33781139
108FGFR20.31295596
109HIPK20.31095539
110MAPK120.30961370
111MAPK80.30676186
112FGR0.30216993
113ROCK20.29528661
114CAMK1G0.29407379
115PRKCA0.29039904
116PRKAA10.25885502
117ERBB20.25872691

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73222395
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29883263
3Olfactory transduction_Homo sapiens_hsa047402.92960908
4Circadian entrainment_Homo sapiens_hsa047132.86134541
5Long-term potentiation_Homo sapiens_hsa047202.75947179
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68138285
7GABAergic synapse_Homo sapiens_hsa047272.66583696
8Glutamatergic synapse_Homo sapiens_hsa047242.66386118
9Amphetamine addiction_Homo sapiens_hsa050312.54652611
10Morphine addiction_Homo sapiens_hsa050322.52673109
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29544238
12Salivary secretion_Homo sapiens_hsa049702.28969809
13Dopaminergic synapse_Homo sapiens_hsa047282.10704577
14Insulin secretion_Homo sapiens_hsa049112.04417295
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98402393
16Cholinergic synapse_Homo sapiens_hsa047251.95185066
17Gastric acid secretion_Homo sapiens_hsa049711.95162878
18* Oxytocin signaling pathway_Homo sapiens_hsa049211.76038813
19Calcium signaling pathway_Homo sapiens_hsa040201.73930149
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70615830
21Renin secretion_Homo sapiens_hsa049241.64840923
22Long-term depression_Homo sapiens_hsa047301.64491314
23Taste transduction_Homo sapiens_hsa047421.62009586
24GnRH signaling pathway_Homo sapiens_hsa049121.58093688
25Cocaine addiction_Homo sapiens_hsa050301.55700238
26Vitamin B6 metabolism_Homo sapiens_hsa007501.55014051
27Serotonergic synapse_Homo sapiens_hsa047261.52448841
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47497694
29cAMP signaling pathway_Homo sapiens_hsa040241.37836994
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36857046
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34799824
32Gap junction_Homo sapiens_hsa045401.30548343
33Collecting duct acid secretion_Homo sapiens_hsa049661.26597249
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24973398
35Nitrogen metabolism_Homo sapiens_hsa009101.22378167
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20024948
37Glioma_Homo sapiens_hsa052141.16152396
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15566963
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09851367
40Type II diabetes mellitus_Homo sapiens_hsa049301.07281570
41Estrogen signaling pathway_Homo sapiens_hsa049151.06442254
42Melanogenesis_Homo sapiens_hsa049161.03936588
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01709736
44Axon guidance_Homo sapiens_hsa043601.01290101
45ErbB signaling pathway_Homo sapiens_hsa040120.99774822
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.98820544
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.96857224
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96708218
49Pancreatic secretion_Homo sapiens_hsa049720.94200857
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92002985
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89518721
52Phototransduction_Homo sapiens_hsa047440.86867412
53Oocyte meiosis_Homo sapiens_hsa041140.85953246
54Vibrio cholerae infection_Homo sapiens_hsa051100.82724854
55Cardiac muscle contraction_Homo sapiens_hsa042600.80424107
56Choline metabolism in cancer_Homo sapiens_hsa052310.80069928
57Thyroid hormone synthesis_Homo sapiens_hsa049180.77544541
58VEGF signaling pathway_Homo sapiens_hsa043700.76653081
59Dilated cardiomyopathy_Homo sapiens_hsa054140.73053935
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72125534
61Dorso-ventral axis formation_Homo sapiens_hsa043200.70719098
62MAPK signaling pathway_Homo sapiens_hsa040100.69928668
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.67782375
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66260749
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63942421
66Rap1 signaling pathway_Homo sapiens_hsa040150.63025227
67Inositol phosphate metabolism_Homo sapiens_hsa005620.62594450
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60088562
69Circadian rhythm_Homo sapiens_hsa047100.60013620
70Glucagon signaling pathway_Homo sapiens_hsa049220.59997288
71Ras signaling pathway_Homo sapiens_hsa040140.56480397
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55287637
73Endocytosis_Homo sapiens_hsa041440.53128238
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.51444845
75mTOR signaling pathway_Homo sapiens_hsa041500.49244447
76Non-small cell lung cancer_Homo sapiens_hsa052230.48899058
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44905047
78Type I diabetes mellitus_Homo sapiens_hsa049400.44749826
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44516538
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43746517
81Bile secretion_Homo sapiens_hsa049760.43741492
82Wnt signaling pathway_Homo sapiens_hsa043100.43681030
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42049681
84Osteoclast differentiation_Homo sapiens_hsa043800.41250314
85Chemokine signaling pathway_Homo sapiens_hsa040620.39903031
86* Alcoholism_Homo sapiens_hsa050340.39234150
87Regulation of autophagy_Homo sapiens_hsa041400.39067487
88Prion diseases_Homo sapiens_hsa050200.38207393
89African trypanosomiasis_Homo sapiens_hsa051430.36993087
90Tuberculosis_Homo sapiens_hsa051520.36000161
91Endometrial cancer_Homo sapiens_hsa052130.35189620
92Fatty acid biosynthesis_Homo sapiens_hsa000610.34267138
93Ovarian steroidogenesis_Homo sapiens_hsa049130.34037799
94* AMPK signaling pathway_Homo sapiens_hsa041520.33868701
95B cell receptor signaling pathway_Homo sapiens_hsa046620.33775578
96HIF-1 signaling pathway_Homo sapiens_hsa040660.33729605
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33691049
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33081362
99Mineral absorption_Homo sapiens_hsa049780.33031278
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32506314
101Platelet activation_Homo sapiens_hsa046110.32363698
102Insulin signaling pathway_Homo sapiens_hsa049100.32275042
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.32073828
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31737680
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30614000
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28625039
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28498543
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27940341
109* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27718905
110Prolactin signaling pathway_Homo sapiens_hsa049170.26585233
111Lysosome_Homo sapiens_hsa041420.25685449
112Renal cell carcinoma_Homo sapiens_hsa052110.24412833
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.24156359
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22922647

Most similar genes based on co-expression Upload to Enrichr

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