CAMKMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.48471388
2multicellular organism reproduction (GO:0032504)8.73821565
3cell wall macromolecule metabolic process (GO:0044036)8.59775686
4cell wall macromolecule catabolic process (GO:0016998)8.59775686
5sperm-egg recognition (GO:0035036)8.12325016
6cell-cell recognition (GO:0009988)7.30911308
7male meiosis (GO:0007140)7.04850108
8cilium or flagellum-dependent cell motility (GO:0001539)6.95757211
9reproduction (GO:0000003)6.54713049
10binding of sperm to zona pellucida (GO:0007339)6.46389534
11protein polyglutamylation (GO:0018095)6.26155915
12fusion of sperm to egg plasma membrane (GO:0007342)6.12001793
13microtubule severing (GO:0051013)5.95586136
14regulation of cilium movement (GO:0003352)5.92964920
15sperm capacitation (GO:0048240)5.67305474
16synaptonemal complex assembly (GO:0007130)5.26335593
17piRNA metabolic process (GO:0034587)4.94109950
18synaptonemal complex organization (GO:0070193)4.77898762
19single fertilization (GO:0007338)4.73657237
20sperm motility (GO:0030317)4.72913194
21plasma membrane fusion (GO:0045026)4.66043798
22proteasome assembly (GO:0043248)4.51304625
23positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.46267530
24DNA double-strand break processing (GO:0000729)4.34663802
25axonemal dynein complex assembly (GO:0070286)4.34574403
26deoxyribose phosphate biosynthetic process (GO:0046385)4.27791379
272-deoxyribonucleotide biosynthetic process (GO:0009265)4.27791379
28DNA deamination (GO:0045006)4.22979805
29protein K6-linked ubiquitination (GO:0085020)4.16112707
30maturation of 5.8S rRNA (GO:0000460)4.09940656
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.07883459
32cilium movement (GO:0003341)4.02393644
33chromatin remodeling at centromere (GO:0031055)3.99176138
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.99091003
35acrosome reaction (GO:0007340)3.93474303
36monoubiquitinated protein deubiquitination (GO:0035520)3.92657770
37pseudouridine synthesis (GO:0001522)3.91686006
38negative regulation of circadian rhythm (GO:0042754)3.91514379
39somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.90295040
40isotype switching (GO:0045190)3.90295040
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.90295040
42peptidyl-lysine dimethylation (GO:0018027)3.88695272
43regulation of helicase activity (GO:0051095)3.88588919
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.87569588
45termination of RNA polymerase III transcription (GO:0006386)3.87569588
46spermatid development (GO:0007286)3.87266935
47intraciliary transport (GO:0042073)3.83813756
48chaperone-mediated protein transport (GO:0072321)3.82425290
49respiratory chain complex IV assembly (GO:0008535)3.82239890
50chromosome organization involved in meiosis (GO:0070192)3.81430620
51meiotic nuclear division (GO:0007126)3.70773806
52peptidyl-histidine modification (GO:0018202)3.64758603
53establishment of integrated proviral latency (GO:0075713)3.63140772
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62611442
55mitochondrial respiratory chain complex assembly (GO:0033108)3.58321875
56protein complex biogenesis (GO:0070271)3.57853434
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.56331970
58NADH dehydrogenase complex assembly (GO:0010257)3.56331970
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56331970
60protein deneddylation (GO:0000338)3.56165110
61cytochrome complex assembly (GO:0017004)3.55668200
62epithelial cilium movement (GO:0003351)3.54317139
63regulation of inositol phosphate biosynthetic process (GO:0010919)3.52770583
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.51979718
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51979718
66fertilization (GO:0009566)3.50655909
67regulation of microtubule-based movement (GO:0060632)3.50059405
68deoxyribonucleotide biosynthetic process (GO:0009263)3.49226353
69regulation of mitotic spindle checkpoint (GO:1903504)3.44599185
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.44599185
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43369794
72somatic recombination of immunoglobulin gene segments (GO:0016447)3.43239940
73DNA damage response, detection of DNA damage (GO:0042769)3.43209632
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.42333413
75transcription from mitochondrial promoter (GO:0006390)3.41833080
76cell recognition (GO:0008037)3.39890982
77somatic diversification of immunoglobulins (GO:0016445)3.39294916
78regulation of mitochondrial translation (GO:0070129)3.39069803
79spermatid nucleus differentiation (GO:0007289)3.32521841
80mitochondrial RNA metabolic process (GO:0000959)3.32147085
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.30294912
82DNA catabolic process, exonucleolytic (GO:0000738)3.28210586
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28013089
84DNA methylation involved in gamete generation (GO:0043046)3.27615728
85mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.27536218
86cullin deneddylation (GO:0010388)3.26738661
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.24728731
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24728731
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24728731
90negative regulation of sister chromatid segregation (GO:0033046)3.24728731
91base-excision repair, AP site formation (GO:0006285)3.23276640
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20172137
93histone H3-K9 methylation (GO:0051567)3.18168576
94histone exchange (GO:0043486)3.15771830
95negative regulation of chromosome segregation (GO:0051985)3.15609265
96DNA replication-independent nucleosome organization (GO:0034724)3.15087054
97DNA replication-independent nucleosome assembly (GO:0006336)3.15087054
98protein kinase C signaling (GO:0070528)3.13848788
99protein neddylation (GO:0045116)3.13086999
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12981965
101kinetochore assembly (GO:0051382)3.11888149
102DNA strand elongation involved in DNA replication (GO:0006271)3.11083149
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07822970
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07822970
105rRNA modification (GO:0000154)3.07018805
106DNA ligation (GO:0006266)3.05494231
107telomere maintenance via semi-conservative replication (GO:0032201)3.05195266
108replication fork processing (GO:0031297)3.04576846
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04458915
110negative regulation of ligase activity (GO:0051352)3.04458915
111histone H3-K9 modification (GO:0061647)3.04144220
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03828427
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03263370
114regulation of sister chromatid segregation (GO:0033045)3.02923117
115regulation of mitotic sister chromatid separation (GO:0010965)3.02923117
116regulation of mitotic sister chromatid segregation (GO:0033047)3.02923117
117protein localization to cilium (GO:0061512)3.02337091
118DNA replication checkpoint (GO:0000076)3.02319796
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01981462
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01623684
121purine nucleobase biosynthetic process (GO:0009113)3.01119987
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99722160
123recombinational repair (GO:0000725)2.98997312
124energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98105213
125ATP synthesis coupled proton transport (GO:0015986)2.98105213
126regulation of spindle checkpoint (GO:0090231)2.97858090
127kinetochore organization (GO:0051383)2.97800075
128negative regulation of mitosis (GO:0045839)2.97322505
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97051289
130double-strand break repair via homologous recombination (GO:0000724)2.96028638
131ribosome assembly (GO:0042255)2.94333407
132peptidyl-lysine trimethylation (GO:0018023)2.94075192
133negative regulation of cell cycle G2/M phase transition (GO:1902750)2.93275568
134negative regulation of B cell mediated immunity (GO:0002713)2.93204713
135negative regulation of immunoglobulin mediated immune response (GO:0002890)2.93204713
136negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.92894164
137negative regulation of DNA recombination (GO:0045910)2.92722983
138DNA strand elongation (GO:0022616)2.92011148
139behavioral response to nicotine (GO:0035095)2.91406564
140mannosylation (GO:0097502)2.89920540
141negative regulation of nuclear division (GO:0051784)2.89892927
142protein-cofactor linkage (GO:0018065)2.89184382
143mitochondrial fission (GO:0000266)2.89115896
144somatic diversification of immune receptors (GO:0002200)2.89032445
145pantothenate metabolic process (GO:0015939)2.88981866
146tRNA processing (GO:0008033)2.88466796
147mitotic recombination (GO:0006312)2.88377477
148regulation of cellular amino acid metabolic process (GO:0006521)2.88340445
149regulation of centriole replication (GO:0046599)2.88226845
150positive regulation of mitochondrial fission (GO:0090141)2.87906052
151nucleobase biosynthetic process (GO:0046112)2.87827726
152somatic cell DNA recombination (GO:0016444)2.87212692
153somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.87212692
154DNA replication-dependent nucleosome organization (GO:0034723)2.86947860
155DNA replication-dependent nucleosome assembly (GO:0006335)2.86947860
156mitotic spindle assembly checkpoint (GO:0007094)2.85548625
157myoblast migration (GO:0051451)2.84952766
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84792598
159Golgi transport vesicle coating (GO:0048200)2.84611063
160COPI coating of Golgi vesicle (GO:0048205)2.84611063
161signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84077069
162signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84077069
163signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84077069
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83560070
165protein targeting to mitochondrion (GO:0006626)2.82268499
166mismatch repair (GO:0006298)2.81550865
167cellular process involved in reproduction in multicellular organism (GO:0022412)2.80896408
168reciprocal meiotic recombination (GO:0007131)2.80549327
169reciprocal DNA recombination (GO:0035825)2.80549327
170signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80543884
171intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80543884
172spliceosomal snRNP assembly (GO:0000387)2.79739206
173telomere maintenance via recombination (GO:0000722)2.79588767
174synapsis (GO:0007129)2.79033282
175calcium ion import (GO:0070509)2.78342270
176centriole replication (GO:0007099)2.77965757
177mitotic spindle checkpoint (GO:0071174)2.77213765
178mitotic metaphase plate congression (GO:0007080)2.76828498
179RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74846939
180viral mRNA export from host cell nucleus (GO:0046784)2.74748203
181ventricular system development (GO:0021591)2.74305721
182respiratory electron transport chain (GO:0022904)2.72634200
183CENP-A containing nucleosome assembly (GO:0034080)2.72120910
184metallo-sulfur cluster assembly (GO:0031163)2.72103940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.92509742
2E2F7_22180533_ChIP-Seq_HELA_Human3.54791552
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.38604945
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18988564
5ELK1_19687146_ChIP-ChIP_HELA_Human2.64459436
6ZNF274_21170338_ChIP-Seq_K562_Hela2.44630329
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35584281
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32184636
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28623552
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.20033110
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14485365
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12850719
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12824205
14RNF2_27304074_Chip-Seq_NSC_Mouse2.12218754
15KAP1_22055183_ChIP-Seq_ESCs_Mouse2.11301493
16EWS_26573619_Chip-Seq_HEK293_Human2.11150077
17IGF1R_20145208_ChIP-Seq_DFB_Human2.09594778
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.06816723
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02870494
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00102110
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98804650
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94376014
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.90527933
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.88937315
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84576194
26MYC_18940864_ChIP-ChIP_HL60_Human1.83650477
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.83338921
28FUS_26573619_Chip-Seq_HEK293_Human1.79812303
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76875469
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74699540
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74693785
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72269941
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70769452
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70525431
35VDR_23849224_ChIP-Seq_CD4+_Human1.68443851
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61428684
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.60250946
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60194086
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59477117
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56028328
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53396391
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53189544
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.51408316
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51202634
45DCP1A_22483619_ChIP-Seq_HELA_Human1.51180662
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50603712
47TAF15_26573619_Chip-Seq_HEK293_Human1.49851183
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49807743
49VDR_22108803_ChIP-Seq_LS180_Human1.49173083
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.47583797
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46994411
52P300_19829295_ChIP-Seq_ESCs_Human1.46512178
53TTF2_22483619_ChIP-Seq_HELA_Human1.45991235
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43627555
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43420570
56FOXP3_21729870_ChIP-Seq_TREG_Human1.42517473
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.41322150
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.40736183
59GABP_19822575_ChIP-Seq_HepG2_Human1.40083848
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39574695
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39106961
62CTCF_18555785_Chip-Seq_ESCs_Mouse1.38662302
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.37860648
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37694719
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37667589
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35503101
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.34192148
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29947826
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29448889
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29395581
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28758901
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28540041
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.28524835
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28454234
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.28266814
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27707561
77TP53_22573176_ChIP-Seq_HFKS_Human1.27176324
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.27122164
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27057646
80ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26879915
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26592204
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26032164
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25446016
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25384203
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25023646
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24896367
87IRF1_19129219_ChIP-ChIP_H3396_Human1.24699569
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24461841
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.24120327
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.23924528
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.23596672
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21276305
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21072610
94XRN2_22483619_ChIP-Seq_HELA_Human1.20963882
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.20800164
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19900788
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19862134
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19756900
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19197818
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19007759
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18397565
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18133435
103P300_18555785_Chip-Seq_ESCs_Mouse1.17769208
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17648709
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16676148
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15952004
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.15895336
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.15524334
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15472779
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.15348300
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.12972880
112P53_22387025_ChIP-Seq_ESCs_Mouse1.12718446
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.11977548
114GATA3_21867929_ChIP-Seq_CD8_Mouse1.08997041
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07537241
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.07399688
117SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06311733
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06136150
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.06121138
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.05875143
121GATA3_21867929_ChIP-Seq_TH1_Mouse1.05369797
122GBX2_23144817_ChIP-Seq_PC3_Human1.04353581
123ZFX_18555785_Chip-Seq_ESCs_Mouse1.03247402
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03079146
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02948506
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01716626
127SPI1_26923725_Chip-Seq_HPCs_Mouse0.99873123
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99841814
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99531630
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98897161
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98130017
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.97595573
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97569927
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96878041
135CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96157366
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95942445
137MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95898052
138KDM5A_27292631_Chip-Seq_BREAST_Human0.93773197
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93686790
140FOXA1_25329375_ChIP-Seq_VCAP_Human0.93686790
141ER_23166858_ChIP-Seq_MCF-7_Human0.92930001
142NANOG_19829295_ChIP-Seq_ESCs_Human0.90695263
143SOX2_19829295_ChIP-Seq_ESCs_Human0.90695263
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90274683
145CIITA_25753668_ChIP-Seq_RAJI_Human0.85637708
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84371373
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83739836
148CBP_20019798_ChIP-Seq_JUKART_Human0.83739836
149AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82469018
150TP63_19390658_ChIP-ChIP_HaCaT_Human0.81705734
151AR_20517297_ChIP-Seq_VCAP_Human0.80877126
152HOXB7_26014856_ChIP-Seq_BT474_Human0.80635031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.00621244
2MP0008877_abnormal_DNA_methylation4.89279928
3MP0002653_abnormal_ependyma_morphology4.79297444
4MP0008058_abnormal_DNA_repair4.29830912
5MP0001984_abnormal_olfaction3.55248357
6MP0010094_abnormal_chromosome_stability3.01706884
7MP0001929_abnormal_gametogenesis2.98667045
8MP0009046_muscle_twitch2.88183995
9MP0003698_abnormal_male_reproductive2.86075215
10MP0003136_yellow_coat_color2.73290958
11MP0008057_abnormal_DNA_replication2.68763624
12MP0003693_abnormal_embryo_hatching2.57464112
13MP0003787_abnormal_imprinting2.42888940
14MP0002210_abnormal_sex_determination2.37665991
15MP0005646_abnormal_pituitary_gland2.30034328
16MP0009697_abnormal_copulation2.27863400
17MP0008007_abnormal_cellular_replicative2.27019899
18MP0003121_genomic_imprinting2.18044964
19MP0003122_maternal_imprinting2.16382586
20MP0000653_abnormal_sex_gland2.12959263
21MP0005645_abnormal_hypothalamus_physiol2.09998914
22MP0001145_abnormal_male_reproductive2.09499183
23MP0002938_white_spotting2.00977479
24MP0003786_premature_aging1.96269027
25MP0003806_abnormal_nucleotide_metabolis1.93281531
26MP0004133_heterotaxia1.87643744
27MP0006035_abnormal_mitochondrial_morpho1.81090249
28MP0002161_abnormal_fertility/fecundity1.78690270
29MP0005083_abnormal_biliary_tract1.71454258
30MP0003646_muscle_fatigue1.67884688
31MP0003656_abnormal_erythrocyte_physiolo1.66004559
32MP0002877_abnormal_melanocyte_morpholog1.65134634
33MP0003567_abnormal_fetal_cardiomyocyte1.63989629
34MP0000678_abnormal_parathyroid_gland1.60738131
35MP0003077_abnormal_cell_cycle1.60372820
36MP0005084_abnormal_gallbladder_morpholo1.59247659
37MP0002396_abnormal_hematopoietic_system1.58829284
38MP0003186_abnormal_redox_activity1.57650615
39MP0003763_abnormal_thymus_physiology1.54589797
40MP0005551_abnormal_eye_electrophysiolog1.54447073
41MP0003111_abnormal_nucleus_morphology1.48432702
42MP0001119_abnormal_female_reproductive1.45440502
43MP0005174_abnormal_tail_pigmentation1.38771902
44MP0003183_abnormal_peptide_metabolism1.37080810
45MP0003195_calcinosis1.34817887
46MP0005253_abnormal_eye_physiology1.34278576
47MP0000569_abnormal_digit_pigmentation1.34074460
48MP0002837_dystrophic_cardiac_calcinosis1.29991211
49MP0004233_abnormal_muscle_weight1.29935098
50MP0003123_paternal_imprinting1.29587798
51MP0010386_abnormal_urinary_bladder1.28697063
52MP0005379_endocrine/exocrine_gland_phen1.28634217
53MP0003718_maternal_effect1.26675992
54MP0004957_abnormal_blastocyst_morpholog1.25919564
55MP0006292_abnormal_olfactory_placode1.25289186
56MP0002638_abnormal_pupillary_reflex1.24229416
57MP0008875_abnormal_xenobiotic_pharmacok1.23499341
58MP0001968_abnormal_touch/_nociception1.23170793
59MP0003699_abnormal_female_reproductive1.22625734
60MP0003941_abnormal_skin_development1.21766991
61MP0008995_early_reproductive_senescence1.19958181
62MP0003937_abnormal_limbs/digits/tail_de1.17966031
63MP0006036_abnormal_mitochondrial_physio1.15888374
64MP0005623_abnormal_meninges_morphology1.08837029
65MP0002736_abnormal_nociception_after1.08465091
66MP0002102_abnormal_ear_morphology1.05920827
67MP0003880_abnormal_central_pattern1.04730657
68MP0001986_abnormal_taste_sensitivity1.02766159
69MP0000647_abnormal_sebaceous_gland1.01940155
70MP0002282_abnormal_trachea_morphology0.99361863
71MP0008872_abnormal_physiological_respon0.98145458
72MP0005397_hematopoietic_system_phenotyp0.97689695
73MP0001545_abnormal_hematopoietic_system0.97689695
74MP0001529_abnormal_vocalization0.95307338
75MP0002163_abnormal_gland_morphology0.94938399
76MP0003890_abnormal_embryonic-extraembry0.94486548
77MP0005670_abnormal_white_adipose0.93932216
78MP0000631_abnormal_neuroendocrine_gland0.93187408
79MP0002254_reproductive_system_inflammat0.92149446
80MP0004142_abnormal_muscle_tone0.91744126
81MP0002928_abnormal_bile_duct0.90304362
82MP0003943_abnormal_hepatobiliary_system0.90102078
83MP0001764_abnormal_homeostasis0.89959299
84MP0001905_abnormal_dopamine_level0.88550343
85MP0002090_abnormal_vision0.87867507
86MP0005171_absent_coat_pigmentation0.87430304
87MP0000566_synostosis0.87361735
88MP0001324_abnormal_eye_pigmentation0.86440322
89MP0002160_abnormal_reproductive_system0.85785886
90MP0005367_renal/urinary_system_phenotyp0.85214709
91MP0000516_abnormal_urinary_system0.85214709
92MP0006072_abnormal_retinal_apoptosis0.85148506
93MP0000358_abnormal_cell_content/0.83987208
94MP0005389_reproductive_system_phenotype0.83032090
95MP0001697_abnormal_embryo_size0.81199375
96MP0000313_abnormal_cell_death0.80991156
97MP0002277_abnormal_respiratory_mucosa0.80832635
98MP0004043_abnormal_pH_regulation0.80099623
99MP0006276_abnormal_autonomic_nervous0.80031448
100MP0002095_abnormal_skin_pigmentation0.79443259
101MP0005310_abnormal_salivary_gland0.78421377
102MP0001730_embryonic_growth_arrest0.78219728
103MP0002876_abnormal_thyroid_physiology0.78047489
104MP0000427_abnormal_hair_cycle0.77128003
105MP0001485_abnormal_pinna_reflex0.76655693
106MP0006054_spinal_hemorrhage0.76352435
107MP0001944_abnormal_pancreas_morphology0.76292613
108MP0004215_abnormal_myocardial_fiber0.75800119
109MP0002233_abnormal_nose_morphology0.75285728
110MP0003283_abnormal_digestive_organ0.74715574
111MP0005395_other_phenotype0.74344747
112MP0002572_abnormal_emotion/affect_behav0.73987700
113MP0003879_abnormal_hair_cell0.73277253
114MP0005332_abnormal_amino_acid0.72493866
115MP0001346_abnormal_lacrimal_gland0.71563488
116MP0001188_hyperpigmentation0.71343643
117MP0002693_abnormal_pancreas_physiology0.71203606
118MP0002132_abnormal_respiratory_system0.70635569
119MP0001286_abnormal_eye_development0.69625937
120MP0004808_abnormal_hematopoietic_stem0.69170118
121MP0003221_abnormal_cardiomyocyte_apopto0.68450712
122MP0000015_abnormal_ear_pigmentation0.68342648
123MP0001293_anophthalmia0.66313928
124MP0000372_irregular_coat_pigmentation0.66179885
125MP0002909_abnormal_adrenal_gland0.64311838
126MP0002734_abnormal_mechanical_nocicepti0.63267702
127MP0004147_increased_porphyrin_level0.62968937
128MP0002272_abnormal_nervous_system0.62893119
129MP0005075_abnormal_melanosome_morpholog0.62221887
130MP0000685_abnormal_immune_system0.62055403
131MP0002735_abnormal_chemical_nociception0.61760977
132MP0008932_abnormal_embryonic_tissue0.61082742
133MP0002751_abnormal_autonomic_nervous0.60558930
134MP0004264_abnormal_extraembryonic_tissu0.60235886
135MP0003635_abnormal_synaptic_transmissio0.60212304
136MP0001919_abnormal_reproductive_system0.59761536
137MP0009745_abnormal_behavioral_response0.59356459
138MP0005499_abnormal_olfactory_system0.59035130
139MP0005394_taste/olfaction_phenotype0.59035130
140MP0002019_abnormal_tumor_incidence0.58712397
141MP0008789_abnormal_olfactory_epithelium0.58610325

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.53582426
2Tongue fasciculations (HP:0001308)5.94053478
3Pancreatic fibrosis (HP:0100732)5.42538106
4Abnormal respiratory motile cilium physiology (HP:0012261)5.26444802
5Muscle fibrillation (HP:0010546)5.12723714
6Rhinitis (HP:0012384)4.98563533
7Abnormal ciliary motility (HP:0012262)4.61919267
8Medial flaring of the eyebrow (HP:0010747)4.54226760
9Abnormality of midbrain morphology (HP:0002418)4.16180095
10Molar tooth sign on MRI (HP:0002419)4.16180095
11Chronic bronchitis (HP:0004469)4.06027073
12True hermaphroditism (HP:0010459)3.83283324
13Abnormal spermatogenesis (HP:0008669)3.53217821
14Nephronophthisis (HP:0000090)3.49444756
15Birth length less than 3rd percentile (HP:0003561)3.44237452
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.43998760
17Abnormality of alanine metabolism (HP:0010916)3.43998760
18Hyperalaninemia (HP:0003348)3.43998760
19Gait imbalance (HP:0002141)3.43813078
20Congenital primary aphakia (HP:0007707)3.43135847
21Acute necrotizing encephalopathy (HP:0006965)3.38888137
22Slow saccadic eye movements (HP:0000514)3.32530468
23Pancreatic cysts (HP:0001737)3.29117051
24Degeneration of anterior horn cells (HP:0002398)3.22706495
25Abnormality of the anterior horn cell (HP:0006802)3.22706495
26Bronchitis (HP:0012387)3.22472360
27Mitochondrial inheritance (HP:0001427)3.19354876
28Nephrogenic diabetes insipidus (HP:0009806)3.16610739
29Increased CSF lactate (HP:0002490)3.15112424
30Aplasia/Hypoplasia of the tongue (HP:0010295)3.13467697
31Acute encephalopathy (HP:0006846)3.13010919
32Median cleft lip (HP:0000161)3.03125639
33Abnormal mitochondria in muscle tissue (HP:0008316)3.00744063
34Increased hepatocellular lipid droplets (HP:0006565)2.98652599
35Nasal polyposis (HP:0100582)2.97047668
36Bronchiectasis (HP:0002110)2.94413942
37Male infertility (HP:0003251)2.94222628
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.93382943
39Absent/shortened dynein arms (HP:0200106)2.93382943
40Genital tract atresia (HP:0001827)2.91471181
41Optic nerve hypoplasia (HP:0000609)2.91037475
42Chronic hepatic failure (HP:0100626)2.90386396
43Abnormality of lateral ventricle (HP:0030047)2.88129891
44Hepatocellular necrosis (HP:0001404)2.86392711
45Abnormality of chromosome stability (HP:0003220)2.82105945
46Progressive macrocephaly (HP:0004481)2.81561607
47Lipid accumulation in hepatocytes (HP:0006561)2.76476587
48Meckel diverticulum (HP:0002245)2.71393103
49Polydipsia (HP:0001959)2.70595312
50Abnormal drinking behavior (HP:0030082)2.70595312
51Abnormality of the ileum (HP:0001549)2.70290380
52Recurrent bronchitis (HP:0002837)2.66769218
53Congenital hepatic fibrosis (HP:0002612)2.62826094
54Microglossia (HP:0000171)2.62714165
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.61198361
56Postaxial foot polydactyly (HP:0001830)2.59550139
57Occipital encephalocele (HP:0002085)2.58804805
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51870326
59Increased serum lactate (HP:0002151)2.51266745
60Poor coordination (HP:0002370)2.51100215
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47606616
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47606616
63Cystic liver disease (HP:0006706)2.47553292
64Hepatic necrosis (HP:0002605)2.45612148
65Vaginal atresia (HP:0000148)2.45374682
66Abnormality of saccadic eye movements (HP:0000570)2.44922106
67Azoospermia (HP:0000027)2.42163505
68Ependymoma (HP:0002888)2.41455851
69Colon cancer (HP:0003003)2.38908471
70Broad foot (HP:0001769)2.38758563
71Abnormality of the renal medulla (HP:0100957)2.35391570
72Type I transferrin isoform profile (HP:0003642)2.34750153
73Progressive inability to walk (HP:0002505)2.34237375
74Lactic acidosis (HP:0003128)2.33551023
75Cerebral edema (HP:0002181)2.31486772
76Abnormality of the preputium (HP:0100587)2.31116034
77Methylmalonic aciduria (HP:0012120)2.29696478
78Abnormality of the nasal mucosa (HP:0000433)2.28114483
79Limb ataxia (HP:0002070)2.26166279
80Rhabdomyosarcoma (HP:0002859)2.24942752
81Postaxial hand polydactyly (HP:0001162)2.22532582
82Intestinal atresia (HP:0011100)2.20756950
83Preaxial hand polydactyly (HP:0001177)2.20607240
84Methylmalonic acidemia (HP:0002912)2.20204172
85Impaired smooth pursuit (HP:0007772)2.19781474
86Abnormal respiratory motile cilium morphology (HP:0005938)2.18270368
87Abnormal respiratory epithelium morphology (HP:0012253)2.18270368
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.12946013
89Abnormality of serum amino acid levels (HP:0003112)2.11455886
90Nephroblastoma (Wilms tumor) (HP:0002667)2.11138509
91Hyperglycinuria (HP:0003108)2.10923911
92Papillary thyroid carcinoma (HP:0002895)2.09049339
93Small intestinal stenosis (HP:0012848)2.08442458
94Duodenal stenosis (HP:0100867)2.08442458
95Recurrent otitis media (HP:0000403)2.07277865
96Bile duct proliferation (HP:0001408)2.07031243
97Abnormal biliary tract physiology (HP:0012439)2.07031243
98Medulloblastoma (HP:0002885)2.05937292
99Aplastic anemia (HP:0001915)2.05589090
100Abnormal lung lobation (HP:0002101)2.04833616
101Infertility (HP:0000789)2.04301726
102Hyperglycinemia (HP:0002154)2.03477706
103Facial cleft (HP:0002006)2.03220327
1043-Methylglutaconic aciduria (HP:0003535)2.01854590
105Sloping forehead (HP:0000340)2.01772540
106Microvesicular hepatic steatosis (HP:0001414)2.01596283
107Metaphyseal dysplasia (HP:0100255)1.99853729
108Abnormality of the duodenum (HP:0002246)1.98697600
109Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98154782
110Hypothermia (HP:0002045)1.97537829
111Increased intramyocellular lipid droplets (HP:0012240)1.97085999
112Embryonal renal neoplasm (HP:0011794)1.95675263
113Renal Fanconi syndrome (HP:0001994)1.95364092
114Abnormality of the labia minora (HP:0012880)1.95187890
115Optic nerve coloboma (HP:0000588)1.93585473
116Oculomotor apraxia (HP:0000657)1.93272085
117Pendular nystagmus (HP:0012043)1.92988525
118Aplasia/Hypoplasia of the lens (HP:0008063)1.91929455
119Type 2 muscle fiber atrophy (HP:0003554)1.91619909
120Sclerocornea (HP:0000647)1.90846490
121Glioma (HP:0009733)1.90730880
122B lymphocytopenia (HP:0010976)1.89433328
123Spontaneous abortion (HP:0005268)1.89130509
124Abnormality of the renal cortex (HP:0011035)1.88390550
125Retinal dysplasia (HP:0007973)1.87208955
126Exertional dyspnea (HP:0002875)1.87136387
127Cerebral hypomyelination (HP:0006808)1.86313315
128Triphalangeal thumb (HP:0001199)1.85475997
129Abnormality of glycine metabolism (HP:0010895)1.84744248
130Abnormality of serine family amino acid metabolism (HP:0010894)1.84744248
131Abnormality of methionine metabolism (HP:0010901)1.84049738
132Renal cortical cysts (HP:0000803)1.83371875
133Volvulus (HP:0002580)1.82237791
134Bifid tongue (HP:0010297)1.81169541
135Abolished electroretinogram (ERG) (HP:0000550)1.80701965
136Hypoglycemic seizures (HP:0002173)1.80635576
137CNS demyelination (HP:0007305)1.80193782
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79781884
139Abnormality of the astrocytes (HP:0100707)1.79506395
140Astrocytoma (HP:0009592)1.79506395
141Tubular atrophy (HP:0000092)1.79069888
142Renal dysplasia (HP:0000110)1.78722816
143Agnosia (HP:0010524)1.78363793
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78003267
145Recurrent sinusitis (HP:0011108)1.77087981
146Breast hypoplasia (HP:0003187)1.76970609
147Congenital stationary night blindness (HP:0007642)1.76288471
148Optic disc pallor (HP:0000543)1.76275633
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76243068
150Patellar aplasia (HP:0006443)1.76065833
151Type II lissencephaly (HP:0007260)1.75508053
152Short tibia (HP:0005736)1.74681054
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73611628
154Lethargy (HP:0001254)1.73577785
155Aplasia/Hypoplasia of the patella (HP:0006498)1.73437045
156Tubulointerstitial fibrosis (HP:0005576)1.72945738
157Abnormality of B cell number (HP:0010975)1.72810951
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.72745371
159Gastrointestinal atresia (HP:0002589)1.72608692
160Ectopic kidney (HP:0000086)1.72200688
161Absent frontal sinuses (HP:0002688)1.71703864
162Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70948562
163Abnormality of the metopic suture (HP:0005556)1.69832636
164Short ribs (HP:0000773)1.69631627
165Chromsome breakage (HP:0040012)1.67778005
166Polyuria (HP:0000103)1.67333306
167Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66467105
168Abnormal protein N-linked glycosylation (HP:0012347)1.66467105
169Abnormal protein glycosylation (HP:0012346)1.66467105
170Abnormal glycosylation (HP:0012345)1.66467105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK24.27403446
2VRK23.56017740
3STK38L3.45863533
4ACVR1B3.25152446
5MAP2K73.01603211
6WEE13.01576490
7SIK32.77328249
8NUAK12.76094130
9STK162.70300927
10TRIM282.64904630
11MAP4K22.50269188
12MST42.48293952
13BUB12.32093297
14BRSK12.13377964
15BRAF2.06212143
16CCNB11.86113564
17EIF2AK31.84977718
18PRPF4B1.79964359
19MAPK151.77728635
20STK241.77089237
21MKNK21.74560741
22TTK1.73317354
23PDK41.70319646
24PDK31.70319646
25CASK1.70198371
26BMPR21.57971337
27CDC71.57768059
28PLK41.57260982
29TLK11.54834992
30PASK1.53046576
31CDK81.51128513
32PTK2B1.47785971
33SCYL21.42214730
34KSR11.41811156
35GRK11.41396651
36PLK11.37322969
37MKNK11.34372525
38EIF2AK11.32472847
39CHEK21.32325188
40WNK31.28872180
41WNK41.28249827
42TSSK61.27143954
43VRK11.25774611
44ATR1.20192547
45NME11.19070066
46MAPKAPK51.18281728
47MAPKAPK31.17503500
48PBK1.15743885
49ZAP701.12073532
50OXSR11.10426526
51PRKD31.09745547
52CAMKK21.06378833
53TAF11.03789149
54ERBB31.02207384
55PINK11.02040505
56ARAF1.01849368
57DYRK31.01646443
58ADRBK20.99653396
59CSNK1G10.97114763
60MAPK130.96453515
61MAP3K120.92425648
62PAK30.90855049
63CSNK1G30.90541828
64PLK30.90330761
65PNCK0.86615111
66MAP3K60.85167550
67BCR0.85112065
68CSNK1G20.83683304
69FLT30.80335005
70NEK10.78052775
71CDK190.77912382
72STK390.77808149
73CSNK1A1L0.77593280
74TAOK30.76773231
75MAP2K60.74651162
76EIF2AK20.73618377
77EEF2K0.72593000
78TNIK0.72450893
79ZAK0.71915282
80AURKA0.69236124
81PLK20.67716398
82MAP3K40.66060498
83PDK20.64536296
84LATS10.63574649
85TXK0.61311656
86RAF10.61256319
87INSRR0.60854735
88BTK0.60838700
89FRK0.60592121
90STK100.59761745
91BCKDK0.58503126
92MUSK0.58073352
93DYRK20.56761448
94NLK0.56475903
95NEK60.56376378
96KDR0.56249089
97JAK30.56147405
98RPS6KA50.55633356
99TRPM70.55571237
100NEK20.55358262
101BMPR1B0.54242762
102PRKCI0.51993713
103STK380.50840565
104PIK3CG0.48370979
105STK30.48329025
106CDK30.47181333
107LMTK20.46872397
108MOS0.46383528
109RPS6KB20.46164264
110PRKCE0.45830186
111ATM0.45591203
112CSNK2A10.44423030
113SYK0.44381037
114RPS6KA40.43951379
115ERBB40.42587829
116TAOK20.41538145
117CHEK10.41171859
118AURKB0.39126787
119KIT0.39007930
120TEC0.38995331
121MINK10.38815001
122DAPK10.38707238
123TESK10.38364173
124CSNK1D0.37856255
125CSNK2A20.36687112
126PRKCH0.36563997
127FGFR10.34167525
128TGFBR10.32918268
129CSNK1A10.32621072
130FES0.32311475
131CDK10.32139693
132PIM20.31524080
133STK40.31010856
134SRPK10.30732999
135MARK30.30347671
136CDK180.30312445
137ADRBK10.28909312
138PRKACB0.27751471
139PRKCG0.27508988

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.41684258
2DNA replication_Homo sapiens_hsa030303.30263929
3Protein export_Homo sapiens_hsa030603.06707615
4Oxidative phosphorylation_Homo sapiens_hsa001902.94929443
5Cell cycle_Homo sapiens_hsa041102.92756623
6Mismatch repair_Homo sapiens_hsa034302.88910600
7Homologous recombination_Homo sapiens_hsa034402.85836446
8Base excision repair_Homo sapiens_hsa034102.85359754
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84049410
10Pentose phosphate pathway_Homo sapiens_hsa000302.82909945
11Fanconi anemia pathway_Homo sapiens_hsa034602.47700793
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.38896724
13RNA degradation_Homo sapiens_hsa030182.35430720
14Renin-angiotensin system_Homo sapiens_hsa046142.28960428
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27552635
16Non-homologous end-joining_Homo sapiens_hsa034502.24945031
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.18685691
18Nucleotide excision repair_Homo sapiens_hsa034201.99907492
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.98521823
20RNA transport_Homo sapiens_hsa030131.96645531
21One carbon pool by folate_Homo sapiens_hsa006701.85303772
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79158637
23Purine metabolism_Homo sapiens_hsa002301.72953416
24Oocyte meiosis_Homo sapiens_hsa041141.71409167
25Pyrimidine metabolism_Homo sapiens_hsa002401.70904608
26Spliceosome_Homo sapiens_hsa030401.70628248
27Proteasome_Homo sapiens_hsa030501.68220478
28Ribosome_Homo sapiens_hsa030101.60909542
29Selenocompound metabolism_Homo sapiens_hsa004501.55757555
30Alzheimers disease_Homo sapiens_hsa050101.54519922
31RNA polymerase_Homo sapiens_hsa030201.53658323
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53577645
33Olfactory transduction_Homo sapiens_hsa047401.49558248
34Synaptic vesicle cycle_Homo sapiens_hsa047211.48734490
35Pyruvate metabolism_Homo sapiens_hsa006201.46211652
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46158867
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44389907
38Biosynthesis of amino acids_Homo sapiens_hsa012301.41861717
39N-Glycan biosynthesis_Homo sapiens_hsa005101.37367203
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35496872
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33627396
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29436633
43Phototransduction_Homo sapiens_hsa047441.27381649
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22755125
45Insulin secretion_Homo sapiens_hsa049111.21643587
46Vitamin B6 metabolism_Homo sapiens_hsa007501.21358014
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18957317
48Fatty acid elongation_Homo sapiens_hsa000621.16839984
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16741178
50Huntingtons disease_Homo sapiens_hsa050161.16342990
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15926707
52Vibrio cholerae infection_Homo sapiens_hsa051101.15354045
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14575831
54Steroid biosynthesis_Homo sapiens_hsa001001.11034730
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.10126748
56Amphetamine addiction_Homo sapiens_hsa050311.09996727
57mRNA surveillance pathway_Homo sapiens_hsa030151.07632927
58Sulfur relay system_Homo sapiens_hsa041221.01153991
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98738648
60Caffeine metabolism_Homo sapiens_hsa002320.98600197
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91833176
62Cocaine addiction_Homo sapiens_hsa050300.91353370
63Peroxisome_Homo sapiens_hsa041460.90776592
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88228593
65Butanoate metabolism_Homo sapiens_hsa006500.87565319
66Nitrogen metabolism_Homo sapiens_hsa009100.86824545
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86592758
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.86031014
69Carbon metabolism_Homo sapiens_hsa012000.85562037
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85031740
71Primary immunodeficiency_Homo sapiens_hsa053400.83843922
72Circadian rhythm_Homo sapiens_hsa047100.83756653
73Taste transduction_Homo sapiens_hsa047420.82247412
74Regulation of autophagy_Homo sapiens_hsa041400.74380443
75Nicotine addiction_Homo sapiens_hsa050330.74209678
76Cardiac muscle contraction_Homo sapiens_hsa042600.73421800
77Glucagon signaling pathway_Homo sapiens_hsa049220.71342577
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71225243
79Folate biosynthesis_Homo sapiens_hsa007900.70300689
80p53 signaling pathway_Homo sapiens_hsa041150.69413127
81Dopaminergic synapse_Homo sapiens_hsa047280.66783399
82Epstein-Barr virus infection_Homo sapiens_hsa051690.66772657
83Tryptophan metabolism_Homo sapiens_hsa003800.66604764
84Linoleic acid metabolism_Homo sapiens_hsa005910.65176494
85Morphine addiction_Homo sapiens_hsa050320.64792132
86Collecting duct acid secretion_Homo sapiens_hsa049660.64167377
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59222922
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58604041
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58570750
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53400544
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52539107
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52420361
93Circadian entrainment_Homo sapiens_hsa047130.51724452
94Alcoholism_Homo sapiens_hsa050340.51716140
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51668011
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51395252
97Chemical carcinogenesis_Homo sapiens_hsa052040.48927401
98Viral carcinogenesis_Homo sapiens_hsa052030.48671728
99Sulfur metabolism_Homo sapiens_hsa009200.48388035
100Serotonergic synapse_Homo sapiens_hsa047260.45874906
101Fat digestion and absorption_Homo sapiens_hsa049750.45720192
102Vitamin digestion and absorption_Homo sapiens_hsa049770.45137604
103Retinol metabolism_Homo sapiens_hsa008300.43802798
104Ether lipid metabolism_Homo sapiens_hsa005650.43290926
105Shigellosis_Homo sapiens_hsa051310.43177173
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42635998
107Type I diabetes mellitus_Homo sapiens_hsa049400.41565542
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.41023533
109Arginine and proline metabolism_Homo sapiens_hsa003300.40772518
110Fatty acid degradation_Homo sapiens_hsa000710.40772348
111Metabolic pathways_Homo sapiens_hsa011000.39782960
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39290345
113Ovarian steroidogenesis_Homo sapiens_hsa049130.39161570
114Antigen processing and presentation_Homo sapiens_hsa046120.37949452
115beta-Alanine metabolism_Homo sapiens_hsa004100.37431762
116Galactose metabolism_Homo sapiens_hsa000520.37268181
117HTLV-I infection_Homo sapiens_hsa051660.36892077
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.35563558
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.35268532
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.34460423
121Propanoate metabolism_Homo sapiens_hsa006400.33835906
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32830351
123Long-term potentiation_Homo sapiens_hsa047200.32623959
124Hematopoietic cell lineage_Homo sapiens_hsa046400.31843952
125Herpes simplex infection_Homo sapiens_hsa051680.31335318
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31025693
127Thyroid cancer_Homo sapiens_hsa052160.30126330
128Glycerolipid metabolism_Homo sapiens_hsa005610.29336099
129Arachidonic acid metabolism_Homo sapiens_hsa005900.28844021
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.28656902
131GABAergic synapse_Homo sapiens_hsa047270.28346017
132Fructose and mannose metabolism_Homo sapiens_hsa000510.28252988
133Glutamatergic synapse_Homo sapiens_hsa047240.24939195
134Fatty acid metabolism_Homo sapiens_hsa012120.24515784
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23281917
136Thyroid hormone synthesis_Homo sapiens_hsa049180.20767651
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20476451
138Legionellosis_Homo sapiens_hsa051340.20368811
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19501422
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19036366
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17866468
142Systemic lupus erythematosus_Homo sapiens_hsa053220.14760457
143Glutathione metabolism_Homo sapiens_hsa004800.13876969
144Endocytosis_Homo sapiens_hsa041440.13784906
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12435970
146Parkinsons disease_Homo sapiens_hsa050120.11497537

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