CAMKV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28731329
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.19642774
3synaptic vesicle maturation (GO:0016188)6.09785157
4locomotory exploration behavior (GO:0035641)6.09019654
5vocalization behavior (GO:0071625)5.60159949
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.55697166
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47746627
8regulation of glutamate receptor signaling pathway (GO:1900449)5.34034886
9synaptic vesicle exocytosis (GO:0016079)5.20918303
10regulation of synapse structural plasticity (GO:0051823)5.16024352
11regulation of long-term neuronal synaptic plasticity (GO:0048169)5.12867565
12regulation of neuronal synaptic plasticity (GO:0048168)5.05085507
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.01527742
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.96687267
15protein localization to synapse (GO:0035418)4.95310290
16glutamate secretion (GO:0014047)4.87587732
17exploration behavior (GO:0035640)4.82264044
18regulation of synaptic vesicle exocytosis (GO:2000300)4.78265280
19neurotransmitter-gated ion channel clustering (GO:0072578)4.50283414
20dendritic spine morphogenesis (GO:0060997)4.39135231
21synaptic transmission, glutamatergic (GO:0035249)4.39079672
22glutamate receptor signaling pathway (GO:0007215)4.38853503
23regulation of dendritic spine morphogenesis (GO:0061001)4.37902038
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37136215
25regulation of synaptic vesicle transport (GO:1902803)4.33337358
26long-term memory (GO:0007616)4.31978815
27layer formation in cerebral cortex (GO:0021819)4.31305767
28neurotransmitter secretion (GO:0007269)4.26146282
29neuron-neuron synaptic transmission (GO:0007270)4.21741196
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.18956160
31neuronal action potential propagation (GO:0019227)4.16882780
32neuron cell-cell adhesion (GO:0007158)4.12293523
33positive regulation of membrane potential (GO:0045838)4.12164815
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.10755021
35pyrimidine nucleobase catabolic process (GO:0006208)4.09788322
36presynaptic membrane organization (GO:0097090)4.02764332
37regulation of synaptic plasticity (GO:0048167)4.00309333
38L-amino acid import (GO:0043092)3.96353136
39positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.96114660
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.93409702
41G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.92359226
42regulation of postsynaptic membrane potential (GO:0060078)3.90698734
43prepulse inhibition (GO:0060134)3.89549253
44presynaptic membrane assembly (GO:0097105)3.89309484
45cell migration in hindbrain (GO:0021535)3.89008069
46positive regulation of synapse maturation (GO:0090129)3.88566076
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.87008095
48regulation of voltage-gated calcium channel activity (GO:1901385)3.83878944
49neuromuscular process controlling balance (GO:0050885)3.83735255
50establishment of mitochondrion localization (GO:0051654)3.81802225
51cerebellar granule cell differentiation (GO:0021707)3.79512698
52auditory behavior (GO:0031223)3.75908931
53positive regulation of neurotransmitter secretion (GO:0001956)3.73545847
54long-term synaptic potentiation (GO:0060291)3.70858382
55positive regulation of neurotransmitter transport (GO:0051590)3.69241328
56gamma-aminobutyric acid transport (GO:0015812)3.68504963
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.66170983
58cerebellar Purkinje cell differentiation (GO:0021702)3.64901292
59behavioral defense response (GO:0002209)3.64480633
60behavioral fear response (GO:0001662)3.64480633
61transmission of nerve impulse (GO:0019226)3.63170448
62regulation of female receptivity (GO:0045924)3.62199696
63cellular potassium ion homeostasis (GO:0030007)3.61629247
64proline transport (GO:0015824)3.58962335
65activation of protein kinase A activity (GO:0034199)3.58850424
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.58624378
67synaptic transmission, dopaminergic (GO:0001963)3.56729638
68regulation of dendritic spine development (GO:0060998)3.56396911
69amino acid import (GO:0043090)3.55102039
70neuromuscular synaptic transmission (GO:0007274)3.52255089
71response to auditory stimulus (GO:0010996)3.49725912
72dendritic spine organization (GO:0097061)3.49561375
73positive regulation of dendritic spine development (GO:0060999)3.48413621
74neuron recognition (GO:0008038)3.47437489
75nucleobase catabolic process (GO:0046113)3.46705346
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46629036
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44890069
78neurotransmitter transport (GO:0006836)3.37246030
79regulation of glutamate secretion (GO:0014048)3.37146694
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.37074428
81neuronal ion channel clustering (GO:0045161)3.36971723
82mitochondrion transport along microtubule (GO:0047497)3.36919681
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.36919681
84response to histamine (GO:0034776)3.35737103
85dopamine receptor signaling pathway (GO:0007212)3.35724495
86negative regulation of dendrite morphogenesis (GO:0050774)3.33890749
87learning (GO:0007612)3.32380730
88striatum development (GO:0021756)3.31185159
89fear response (GO:0042596)3.30397551
90regulation of neurotransmitter secretion (GO:0046928)3.30294680
91sodium ion export (GO:0071436)3.30094937
92regulation of vesicle fusion (GO:0031338)3.29747678
93synaptic vesicle endocytosis (GO:0048488)3.29474574
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28194026
95response to amphetamine (GO:0001975)3.27093698
96behavioral response to cocaine (GO:0048148)3.26594758
97neurofilament cytoskeleton organization (GO:0060052)3.24214886
98regulation of synapse maturation (GO:0090128)3.23942597
99membrane depolarization (GO:0051899)3.23242365
100membrane depolarization during action potential (GO:0086010)3.23120832
101regulation of neurotransmitter levels (GO:0001505)3.21815494
102female mating behavior (GO:0060180)3.21764656
103gamma-aminobutyric acid signaling pathway (GO:0007214)3.21369012
104vesicle transport along microtubule (GO:0047496)3.20747797
105positive regulation of synaptic transmission (GO:0050806)3.19411962
106cell communication by electrical coupling (GO:0010644)3.17988908
107innervation (GO:0060384)3.17978393
108mechanosensory behavior (GO:0007638)3.16491720
109axonal fasciculation (GO:0007413)3.15874321
110central nervous system myelination (GO:0022010)3.14724087
111axon ensheathment in central nervous system (GO:0032291)3.14724087
112regulation of neurotransmitter transport (GO:0051588)3.14545904
113membrane hyperpolarization (GO:0060081)3.09825078
114adult walking behavior (GO:0007628)3.09604613
115regulation of synaptic transmission (GO:0050804)3.09136935
116synaptic transmission (GO:0007268)3.07732310
117negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07666642
118postsynaptic membrane organization (GO:0001941)3.06984030
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06401957
120neuromuscular process (GO:0050905)3.05439814
121visual learning (GO:0008542)3.04807314
122negative regulation of amino acid transport (GO:0051956)3.04124267
123dendrite morphogenesis (GO:0048813)3.02274891
124long term synaptic depression (GO:0060292)3.02113588
125neuromuscular process controlling posture (GO:0050884)3.00952104
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00337011
127central nervous system projection neuron axonogenesis (GO:0021952)2.99367613
128acidic amino acid transport (GO:0015800)2.99194475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00626419
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.36099165
3GBX2_23144817_ChIP-Seq_PC3_Human3.33035781
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23499176
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17962826
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13715680
7REST_21632747_ChIP-Seq_MESCs_Mouse2.88790194
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81659143
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81659143
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77457795
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72073344
12DROSHA_22980978_ChIP-Seq_HELA_Human2.71060519
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63506704
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62404701
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.53749527
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52575726
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51478126
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.49704606
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.39007776
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37997430
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32594967
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31732175
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.26490982
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20215243
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.18718365
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07937348
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04158957
28AR_21572438_ChIP-Seq_LNCaP_Human1.89739908
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89603124
30* ERG_21242973_ChIP-ChIP_JURKAT_Human1.62956840
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59256198
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57742379
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51337294
34SMAD4_21799915_ChIP-Seq_A2780_Human1.50321208
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.50200237
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47228252
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41732257
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41723641
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.39070057
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38807920
41* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38245276
42TAF15_26573619_Chip-Seq_HEK293_Human1.35368456
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31845730
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29330789
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27912569
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.26811209
47ZNF274_21170338_ChIP-Seq_K562_Hela1.25444040
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24647731
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24151517
50KDM2B_26808549_Chip-Seq_K562_Human1.23391085
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22970235
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22522763
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22463169
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.22383736
55AR_19668381_ChIP-Seq_PC3_Human1.21222195
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20666600
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20218698
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20218698
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18998236
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.17820575
61P300_19829295_ChIP-Seq_ESCs_Human1.16894075
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16003972
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15922275
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15320089
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15149109
66AR_25329375_ChIP-Seq_VCAP_Human1.14915638
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14782489
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14145720
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14085102
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13873756
71STAT3_23295773_ChIP-Seq_U87_Human1.12974611
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10497670
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10481156
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05829394
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05444228
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.05004271
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04483898
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03372143
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03195553
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02126622
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01933012
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00883775
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.00487388
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00408658
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99872848
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99344711
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98915714
88TCF4_23295773_ChIP-Seq_U87_Human0.98381927
89CTCF_27219007_Chip-Seq_Bcells_Human0.97936211
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.96852518
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96380167
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94154054
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.94058929
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93839558
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.93687896
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93433948
97SOX9_26525672_Chip-Seq_HEART_Mouse0.92681231
98TP53_16413492_ChIP-PET_HCT116_Human0.92550295
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.91010267
100AHR_22903824_ChIP-Seq_MCF-7_Human0.90886622
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.90728532
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90220747
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.89588854
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.88046554
105RUNX2_22187159_ChIP-Seq_PCA_Human0.87532674
106RXR_22108803_ChIP-Seq_LS180_Human0.86976240
107RNF2_27304074_Chip-Seq_NSC_Mouse0.84781019
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.84508128
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.83967748
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83214614
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82698695
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82697341
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82211102
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82004062
115JUN_21703547_ChIP-Seq_K562_Human0.81318415
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81113964
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80919922
118POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.79301785
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76483106
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75496847
121IGF1R_20145208_ChIP-Seq_DFB_Human0.74398733
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74190644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.51169763
2MP0003880_abnormal_central_pattern5.02704418
3MP0002822_catalepsy4.84553171
4MP0003635_abnormal_synaptic_transmissio4.44652530
5MP0004270_analgesia3.80010237
6MP0009745_abnormal_behavioral_response3.70949026
7MP0002063_abnormal_learning/memory/cond3.69422656
8MP0002064_seizures3.21520708
9MP0002572_abnormal_emotion/affect_behav2.92705087
10MP0001968_abnormal_touch/_nociception2.85008420
11MP0009046_muscle_twitch2.76221373
12MP0001486_abnormal_startle_reflex2.64539408
13MP0005423_abnormal_somatic_nervous2.62690732
14MP0002272_abnormal_nervous_system2.54944581
15MP0002734_abnormal_mechanical_nocicepti2.42391390
16MP0001501_abnormal_sleep_pattern2.32923965
17MP0002736_abnormal_nociception_after2.17078984
18MP0001440_abnormal_grooming_behavior2.05315579
19MP0009780_abnormal_chondrocyte_physiolo2.02188581
20MP0002909_abnormal_adrenal_gland1.97186320
21MP0002735_abnormal_chemical_nociception1.97078177
22MP0003329_amyloid_beta_deposits1.93203392
23MP0002733_abnormal_thermal_nociception1.87523727
24MP0001970_abnormal_pain_threshold1.86164002
25MP0004811_abnormal_neuron_physiology1.82668182
26MP0003123_paternal_imprinting1.78319193
27MP0005386_behavior/neurological_phenoty1.76130891
28MP0004924_abnormal_behavior1.76130891
29MP0008569_lethality_at_weaning1.75082681
30MP0001529_abnormal_vocalization1.74705208
31MP0002557_abnormal_social/conspecific_i1.72436652
32MP0002067_abnormal_sensory_capabilities1.70248478
33MP0005646_abnormal_pituitary_gland1.68820595
34MP0004858_abnormal_nervous_system1.64145796
35MP0000778_abnormal_nervous_system1.63585307
36MP0002184_abnormal_innervation1.59193973
37MP0008877_abnormal_DNA_methylation1.59046420
38MP0003879_abnormal_hair_cell1.58922596
39MP0004885_abnormal_endolymph1.48435534
40MP0000955_abnormal_spinal_cord1.46368158
41MP0001984_abnormal_olfaction1.43788794
42MP0003121_genomic_imprinting1.41090143
43MP0002066_abnormal_motor_capabilities/c1.38949059
44MP0003633_abnormal_nervous_system1.35950539
45MP0003787_abnormal_imprinting1.35300700
46MP0002882_abnormal_neuron_morphology1.33754565
47MP0003075_altered_response_to1.31165727
48MP0001905_abnormal_dopamine_level1.24357974
49MP0002638_abnormal_pupillary_reflex1.23395857
50MP0002653_abnormal_ependyma_morphology1.14857785
51MP0006276_abnormal_autonomic_nervous1.12926144
52MP0001188_hyperpigmentation1.12301996
53MP0003631_nervous_system_phenotype1.12077760
54MP0001502_abnormal_circadian_rhythm1.10105389
55MP0008874_decreased_physiological_sensi1.07664561
56MP0008872_abnormal_physiological_respon1.07073152
57MP0002152_abnormal_brain_morphology1.05948142
58MP0001177_atelectasis1.03813254
59MP0005409_darkened_coat_color1.02187867
60MP0005645_abnormal_hypothalamus_physiol1.01341258
61MP0010234_abnormal_vibrissa_follicle0.99609643
62MP0006292_abnormal_olfactory_placode0.97307423
63MP0002069_abnormal_eating/drinking_beha0.96827745
64MP0003283_abnormal_digestive_organ0.95893460
65MP0008961_abnormal_basal_metabolism0.94528422
66MP0004142_abnormal_muscle_tone0.94281740
67MP0005167_abnormal_blood-brain_barrier0.92503692
68MP0000604_amyloidosis0.90656528
69MP0000751_myopathy0.89077003
70MP0005535_abnormal_body_temperature0.88891304
71MP0004085_abnormal_heartbeat0.87513362
72MP0002229_neurodegeneration0.85172451
73MP0003690_abnormal_glial_cell0.83804333
74MP0000013_abnormal_adipose_tissue0.83335804
75MP0002090_abnormal_vision0.82666621
76MP0001346_abnormal_lacrimal_gland0.82324943
77MP0000569_abnormal_digit_pigmentation0.81649358
78MP0005499_abnormal_olfactory_system0.77746631
79MP0005394_taste/olfaction_phenotype0.77746631
80MP0005551_abnormal_eye_electrophysiolog0.77450400
81MP0003890_abnormal_embryonic-extraembry0.76517349
82MP0004133_heterotaxia0.76350804
83MP0003634_abnormal_glial_cell0.75213776
84MP0003122_maternal_imprinting0.75121534
85MP0003119_abnormal_digestive_system0.73278746
86MP0000920_abnormal_myelination0.72365267
87MP0003938_abnormal_ear_development0.72174382
88MP0004510_myositis0.72092350
89MP0001299_abnormal_eye_distance/0.71941183
90MP0003632_abnormal_nervous_system0.71103307
91MP0002751_abnormal_autonomic_nervous0.69912564
92MP0002102_abnormal_ear_morphology0.66231984
93MP0001986_abnormal_taste_sensitivity0.66155623
94MP0000631_abnormal_neuroendocrine_gland0.65337576
95MP0010386_abnormal_urinary_bladder0.64550653
96MP0001963_abnormal_hearing_physiology0.64160340
97MP0000026_abnormal_inner_ear0.64139243
98MP0010770_preweaning_lethality0.63627046
99MP0002082_postnatal_lethality0.63627046
100MP0003137_abnormal_impulse_conducting0.62522008
101MP0010768_mortality/aging0.61779098
102MP0001664_abnormal_digestion0.61669837
103MP0004742_abnormal_vestibular_system0.61171233
104MP0002081_perinatal_lethality0.60502612
105MP0002752_abnormal_somatic_nervous0.59912377
106MP0001348_abnormal_lacrimal_gland0.59438448
107MP0002837_dystrophic_cardiac_calcinosis0.59014790
108MP0004145_abnormal_muscle_electrophysio0.58873678
109MP0004147_increased_porphyrin_level0.57606290
110MP0004484_altered_response_of0.57193517
111MP0008789_abnormal_olfactory_epithelium0.56866071
112MP0005187_abnormal_penis_morphology0.56061027
113MP0004215_abnormal_myocardial_fiber0.56028843
114MP0004233_abnormal_muscle_weight0.54914575
115MP0000566_synostosis0.54429726
116MP0005166_decreased_susceptibility_to0.53593301
117MP0005623_abnormal_meninges_morphology0.52451416
118MP0001485_abnormal_pinna_reflex0.52339862
119MP0002234_abnormal_pharynx_morphology0.51912962
120MP0003172_abnormal_lysosome_physiology0.51058655
121MP0003861_abnormal_nervous_system0.49463660
122MP0003956_abnormal_body_size0.48466631
123MP0002876_abnormal_thyroid_physiology0.48091820
124MP0001943_abnormal_respiration0.47902273
125MP0010769_abnormal_survival0.46753233

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.32951528
2Focal motor seizures (HP:0011153)8.06146906
3Focal seizures (HP:0007359)5.96701495
4Visual hallucinations (HP:0002367)5.36831034
5Epileptic encephalopathy (HP:0200134)4.65272598
6Atonic seizures (HP:0010819)4.05116539
7Febrile seizures (HP:0002373)4.03556784
8Absence seizures (HP:0002121)4.02876738
9Generalized tonic-clonic seizures (HP:0002069)3.85118550
10Action tremor (HP:0002345)3.82073148
11Poor eye contact (HP:0000817)3.80422450
12Dialeptic seizures (HP:0011146)3.74110688
13Impaired vibration sensation in the lower limbs (HP:0002166)3.73869442
14Progressive cerebellar ataxia (HP:0002073)3.72846452
15Ankle clonus (HP:0011448)3.66924877
16Broad-based gait (HP:0002136)3.66621967
17Supranuclear gaze palsy (HP:0000605)3.64121186
18Depression (HP:0000716)3.54305657
19Abnormal social behavior (HP:0012433)3.41172302
20Impaired social interactions (HP:0000735)3.41172302
21Anxiety (HP:0000739)3.41127469
22Urinary bladder sphincter dysfunction (HP:0002839)3.35259729
23Torticollis (HP:0000473)3.31505051
24Dysdiadochokinesis (HP:0002075)3.29436346
25Cerebral hypomyelination (HP:0006808)3.27567193
26Papilledema (HP:0001085)3.26856866
27Abnormality of the lower motor neuron (HP:0002366)3.25171818
28Mutism (HP:0002300)3.20814849
29Dysmetria (HP:0001310)3.20218751
30Gaze-evoked nystagmus (HP:0000640)3.19632549
31Annular pancreas (HP:0001734)3.16353505
32Postural instability (HP:0002172)3.11870612
33Hyperventilation (HP:0002883)3.07149968
34Focal dystonia (HP:0004373)3.06132085
35Amblyopia (HP:0000646)3.03189513
36Cerebral inclusion bodies (HP:0100314)3.02012454
37Urinary urgency (HP:0000012)2.94191166
38Neurofibrillary tangles (HP:0002185)2.93328986
39Abnormal eating behavior (HP:0100738)2.91874792
40Truncal ataxia (HP:0002078)2.89867615
41Stereotypic behavior (HP:0000733)2.88365517
42Craniofacial dystonia (HP:0012179)2.77092462
43Impaired smooth pursuit (HP:0007772)2.73226414
44Bradykinesia (HP:0002067)2.66829415
45Spastic gait (HP:0002064)2.64826768
46Excessive salivation (HP:0003781)2.63655585
47Drooling (HP:0002307)2.63655585
48Megalencephaly (HP:0001355)2.59393016
49Intention tremor (HP:0002080)2.59376555
50Resting tremor (HP:0002322)2.57829645
51Hemiparesis (HP:0001269)2.53633117
52Impaired vibratory sensation (HP:0002495)2.52788698
53Abnormality of binocular vision (HP:0011514)2.51093670
54Diplopia (HP:0000651)2.51093670
55Genetic anticipation (HP:0003743)2.50780715
56Scanning speech (HP:0002168)2.50533163
57Pointed chin (HP:0000307)2.50212652
58Ankyloglossia (HP:0010296)2.49191971
59Sleep apnea (HP:0010535)2.47898783
60Progressive inability to walk (HP:0002505)2.45103977
61Epileptiform EEG discharges (HP:0011182)2.44346328
62Abnormality of the labia minora (HP:0012880)2.38117382
63Akinesia (HP:0002304)2.37419739
64Dysmetric saccades (HP:0000641)2.35205970
65Ventricular fibrillation (HP:0001663)2.34024492
66Abnormality of ocular smooth pursuit (HP:0000617)2.33167377
67EEG with generalized epileptiform discharges (HP:0011198)2.32783567
68Lower limb amyotrophy (HP:0007210)2.32636309
69Tetraplegia (HP:0002445)2.27325716
70Termporal pattern (HP:0011008)2.27126710
71Insidious onset (HP:0003587)2.27126710
72Hepatoblastoma (HP:0002884)2.26686888
73Lower limb muscle weakness (HP:0007340)2.26318438
74Hemiplegia (HP:0002301)2.25670092
75Spastic tetraparesis (HP:0001285)2.25258058
76Status epilepticus (HP:0002133)2.24477616
77Obstructive sleep apnea (HP:0002870)2.22650911
78Hypsarrhythmia (HP:0002521)2.21950749
79Amyotrophic lateral sclerosis (HP:0007354)2.21491159
80Peripheral hypomyelination (HP:0007182)2.19925879
81Insomnia (HP:0100785)2.17452277
82Poor suck (HP:0002033)2.16483806
83Absent speech (HP:0001344)2.16211872
84Fetal akinesia sequence (HP:0001989)2.15365659
85CNS hypomyelination (HP:0003429)2.14927933
86Generalized myoclonic seizures (HP:0002123)2.13790916
87Spastic tetraplegia (HP:0002510)2.10790375
88Incomplete penetrance (HP:0003829)2.09955000
89Failure to thrive in infancy (HP:0001531)2.09790967
90Abnormality of the corticospinal tract (HP:0002492)2.09007888
91Abnormal EKG (HP:0003115)2.07761343
92Delusions (HP:0000746)2.07220573
93Morphological abnormality of the pyramidal tract (HP:0002062)2.06716874
94Clonus (HP:0002169)2.05006224
95Limb dystonia (HP:0002451)2.04216455
96Apathy (HP:0000741)2.03292840
97Inability to walk (HP:0002540)2.01614166
98Lower limb asymmetry (HP:0100559)2.00078720
99Neuronal loss in central nervous system (HP:0002529)1.99441502
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.98836044
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98836044
102Rapidly progressive (HP:0003678)1.94458151
103Bundle branch block (HP:0011710)1.93838554
104Inappropriate behavior (HP:0000719)1.93648829
105Gait ataxia (HP:0002066)1.89992170
106Gait imbalance (HP:0002141)1.85316937
107Rigidity (HP:0002063)1.84496077
108Abnormality of oral frenula (HP:0000190)1.83618429
109Specific learning disability (HP:0001328)1.81678749
110Split foot (HP:0001839)1.81437441
111Polyphagia (HP:0002591)1.81139174
112Hand muscle atrophy (HP:0009130)1.79075628
113Hypoplasia of the corpus callosum (HP:0002079)1.78812204
114Abnormality of the periventricular white matter (HP:0002518)1.77778176
115Cortical dysplasia (HP:0002539)1.77771255
116Diminished motivation (HP:0000745)1.77223487
117Prolonged QT interval (HP:0001657)1.75902018
118Anosmia (HP:0000458)1.72677860
119Abnormality of saccadic eye movements (HP:0000570)1.72592450
120Psychosis (HP:0000709)1.72298138
121Abnormality of salivation (HP:0100755)1.72167988
122Intellectual disability, profound (HP:0002187)1.69025576
123Choreoathetosis (HP:0001266)1.60875032
124Agitation (HP:0000713)1.58820167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.18274235
2NTRK34.52981197
3MAP3K94.08350187
4MARK12.80389446
5DAPK22.75340363
6KSR22.66397242
7MINK12.60654993
8RIPK42.50077182
9PRKD32.46752471
10MAP3K42.46692489
11PAK62.10455813
12CAMKK11.97596826
13MAP2K71.94984623
14NTRK21.89414816
15KSR11.89252236
16NTRK11.82135584
17ARAF1.81203415
18MAP3K131.80900885
19DAPK11.74016620
20CDK51.61331570
21FES1.57010188
22MAP2K41.52930655
23DYRK21.51282289
24SIK21.50866605
25MAP3K121.45622640
26PRPF4B1.41349359
27TNIK1.40453585
28MAP3K21.33371347
29STK381.27827352
30TYRO31.25308946
31PLK21.23960944
32RAF11.22015342
33TAOK11.20192583
34GRK51.15327685
35PRKCG1.13589587
36PTK2B1.04701082
37PNCK1.03433447
38MAPK131.00551304
39CAMK1D0.99481518
40BMPR20.97313153
41CAMK10.94869322
42BCR0.93359306
43CAMK2A0.92293145
44CDK180.90024201
45CDK150.89436469
46CASK0.88140315
47UHMK10.87843934
48CDK190.87205042
49CDK140.85650735
50CAMKK20.84959733
51PRKCH0.83976973
52STK110.83030174
53CAMK2B0.82978132
54LATS20.81603786
55PKN10.80679163
56PINK10.79383500
57WNK30.78702941
58CDK11A0.78348010
59PHKG10.77249218
60PHKG20.77249218
61MARK20.75377071
62SGK2230.73947931
63SGK4940.73947931
64RET0.73835498
65ALK0.72933325
66PDK10.72209908
67SGK10.71512574
68PDPK10.69521985
69MAP3K10.68517986
70CSNK1G30.61553284
71DYRK1A0.60805944
72PAK30.58994409
73NEK10.58413349
74NME10.56423484
75SGK20.56229935
76PRKCZ0.55716631
77LMTK20.55486905
78SGK30.54925581
79CSNK1E0.54110372
80MAP3K70.53394353
81CSNK1A1L0.53334904
82FGR0.52492398
83TNK20.51749796
84FGFR20.49221610
85TRIM280.49178651
86RPS6KA30.48757812
87FYN0.48704086
88MAP2K10.47891639
89CSNK1G20.47395747
90ERBB20.47257229
91DMPK0.46388004
92DAPK30.46039077
93BRSK10.45960798
94NEK60.45675481
95MAPK100.45199151
96DYRK1B0.44770551
97CSNK1G10.44551905
98LIMK10.42678548
99CCNB10.40745660
100PLK30.40309092
101PRKCE0.39767862
102MAPK120.39579045
103CAMK40.39549721
104MOS0.39158060
105CAMK2D0.38965837
106BRAF0.38904387
107CSNK1D0.38645914
108PRKD20.37342621
109SCYL20.37260031
110OXSR10.36460581
111RIPK10.36349708
112MAPK80.35243629
113CAMK2G0.34440411
114FER0.34375057
115GSK3B0.32821628
116PRKACA0.32392017
117CSNK1A10.32239013
118CDC42BPA0.32215591
119MAP3K60.31923589
120PRKG10.31331948
121PRKDC0.31189394
122PRKCB0.30430889
123CAMK1G0.27308749
124MAP3K110.26974110
125PRKCA0.26307781
126TSSK60.23697468

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.51630275
2Olfactory transduction_Homo sapiens_hsa047403.17408993
3Synaptic vesicle cycle_Homo sapiens_hsa047213.01000142
4Long-term potentiation_Homo sapiens_hsa047202.88575175
5Circadian entrainment_Homo sapiens_hsa047132.83369068
6GABAergic synapse_Homo sapiens_hsa047272.69491091
7Amphetamine addiction_Homo sapiens_hsa050312.67891418
8Glutamatergic synapse_Homo sapiens_hsa047242.64844914
9Morphine addiction_Homo sapiens_hsa050322.64630125
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63106448
11Dopaminergic synapse_Homo sapiens_hsa047282.28883923
12Salivary secretion_Homo sapiens_hsa049702.22469179
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17386002
14Cholinergic synapse_Homo sapiens_hsa047252.04799295
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94331666
16Gastric acid secretion_Homo sapiens_hsa049711.93604846
17Insulin secretion_Homo sapiens_hsa049111.91475168
18Cocaine addiction_Homo sapiens_hsa050301.88526092
19Renin secretion_Homo sapiens_hsa049241.82962976
20Oxytocin signaling pathway_Homo sapiens_hsa049211.79928294
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71109157
22Calcium signaling pathway_Homo sapiens_hsa040201.70750317
23Long-term depression_Homo sapiens_hsa047301.65571844
24Serotonergic synapse_Homo sapiens_hsa047261.60089543
25Taste transduction_Homo sapiens_hsa047421.57332788
26GnRH signaling pathway_Homo sapiens_hsa049121.55865002
27Gap junction_Homo sapiens_hsa045401.45886489
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38860827
29cAMP signaling pathway_Homo sapiens_hsa040241.34229083
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33610064
31Vitamin B6 metabolism_Homo sapiens_hsa007501.29644892
32Glioma_Homo sapiens_hsa052141.28032245
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26476463
34Nitrogen metabolism_Homo sapiens_hsa009101.22822266
35Estrogen signaling pathway_Homo sapiens_hsa049151.16965281
36Collecting duct acid secretion_Homo sapiens_hsa049661.14106749
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13478782
38Type II diabetes mellitus_Homo sapiens_hsa049301.10091581
39Melanogenesis_Homo sapiens_hsa049161.07881806
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07718437
41Axon guidance_Homo sapiens_hsa043601.06331098
42ErbB signaling pathway_Homo sapiens_hsa040121.02393136
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.98460945
44Oocyte meiosis_Homo sapiens_hsa041140.97480960
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96988141
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95052127
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94526157
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.92297112
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90606541
50Phototransduction_Homo sapiens_hsa047440.84729463
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84635204
52Pancreatic secretion_Homo sapiens_hsa049720.81148164
53Dorso-ventral axis formation_Homo sapiens_hsa043200.81021069
54Cardiac muscle contraction_Homo sapiens_hsa042600.80989820
55VEGF signaling pathway_Homo sapiens_hsa043700.79459885
56Alzheimers disease_Homo sapiens_hsa050100.78933822
57Choline metabolism in cancer_Homo sapiens_hsa052310.77900961
58Thyroid hormone synthesis_Homo sapiens_hsa049180.76082694
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74257710
60Parkinsons disease_Homo sapiens_hsa050120.72174559
61Oxidative phosphorylation_Homo sapiens_hsa001900.70406285
62Dilated cardiomyopathy_Homo sapiens_hsa054140.69935033
63Vibrio cholerae infection_Homo sapiens_hsa051100.69041519
64MAPK signaling pathway_Homo sapiens_hsa040100.68073538
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66092757
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.65736474
67Rap1 signaling pathway_Homo sapiens_hsa040150.64761373
68Non-small cell lung cancer_Homo sapiens_hsa052230.62951150
69Alcoholism_Homo sapiens_hsa050340.62501824
70Glucagon signaling pathway_Homo sapiens_hsa049220.59904074
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58424669
72Ras signaling pathway_Homo sapiens_hsa040140.57743736
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57725093
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.56056185
75mTOR signaling pathway_Homo sapiens_hsa041500.55865061
76Type I diabetes mellitus_Homo sapiens_hsa049400.54481495
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52502690
78Bile secretion_Homo sapiens_hsa049760.50399131
79Prion diseases_Homo sapiens_hsa050200.50329715
80Endocytosis_Homo sapiens_hsa041440.48594489
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48430249
82Hippo signaling pathway_Homo sapiens_hsa043900.47473894
83African trypanosomiasis_Homo sapiens_hsa051430.47311100
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46662035
85Endometrial cancer_Homo sapiens_hsa052130.44827409
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44372281
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42780109
88Inositol phosphate metabolism_Homo sapiens_hsa005620.42692478
89Chemokine signaling pathway_Homo sapiens_hsa040620.42526052
90Tight junction_Homo sapiens_hsa045300.39835848
91Huntingtons disease_Homo sapiens_hsa050160.39549033
92Renal cell carcinoma_Homo sapiens_hsa052110.38970808
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38498606
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37845727
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37829244
96Wnt signaling pathway_Homo sapiens_hsa043100.37759041
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37686622
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36760052
99Insulin signaling pathway_Homo sapiens_hsa049100.35782869
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35095718
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34295198
102Circadian rhythm_Homo sapiens_hsa047100.33422719
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32961688
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32838634
105Steroid biosynthesis_Homo sapiens_hsa001000.32232209
106Fatty acid biosynthesis_Homo sapiens_hsa000610.30613972
107Arginine and proline metabolism_Homo sapiens_hsa003300.29786606
108Ovarian steroidogenesis_Homo sapiens_hsa049130.29569857
109Hedgehog signaling pathway_Homo sapiens_hsa043400.29536763
110Platelet activation_Homo sapiens_hsa046110.27447914
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27348792
112Arginine biosynthesis_Homo sapiens_hsa002200.25025669
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24275347
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23857447
115mRNA surveillance pathway_Homo sapiens_hsa030150.23499821
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22963887
117Regulation of autophagy_Homo sapiens_hsa041400.20461510
118AMPK signaling pathway_Homo sapiens_hsa041520.19630605

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