CAMTA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.09767072
2locomotory exploration behavior (GO:0035641)5.88832376
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80310749
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35206900
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07765191
6glutamate secretion (GO:0014047)4.97469001
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.95471766
8synaptic vesicle exocytosis (GO:0016079)4.90973571
9vocalization behavior (GO:0071625)4.90706820
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80628729
11regulation of glutamate receptor signaling pathway (GO:1900449)4.63280716
12regulation of synaptic vesicle exocytosis (GO:2000300)4.51018769
13sodium ion export (GO:0071436)4.49201177
14regulation of neuronal synaptic plasticity (GO:0048168)4.35448637
15regulation of synapse structural plasticity (GO:0051823)4.33862133
16exploration behavior (GO:0035640)4.23999009
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.22679410
18cellular potassium ion homeostasis (GO:0030007)4.19087028
19regulation of synaptic vesicle transport (GO:1902803)4.15412503
20neurotransmitter secretion (GO:0007269)4.07339878
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07011328
22neuronal action potential propagation (GO:0019227)4.04915501
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89844739
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81309061
25protein localization to synapse (GO:0035418)3.80811142
26long-term memory (GO:0007616)3.74803008
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70459219
28neurotransmitter-gated ion channel clustering (GO:0072578)3.69725798
29regulation of ARF protein signal transduction (GO:0032012)3.69588897
30synaptic transmission, glutamatergic (GO:0035249)3.66845409
31negative regulation of erythrocyte differentiation (GO:0045647)3.66773955
32dendritic spine morphogenesis (GO:0060997)3.63671821
33layer formation in cerebral cortex (GO:0021819)3.63406315
34proline transport (GO:0015824)3.62578004
35cell communication by electrical coupling (GO:0010644)3.58960064
36activation of protein kinase A activity (GO:0034199)3.57366466
37glutamate receptor signaling pathway (GO:0007215)3.57169463
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53092186
39cerebellar granule cell differentiation (GO:0021707)3.48628634
40positive regulation of membrane potential (GO:0045838)3.46595621
41gamma-aminobutyric acid transport (GO:0015812)3.43831975
42regulation of synaptic plasticity (GO:0048167)3.43588901
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39343343
44negative regulation of cell killing (GO:0031342)3.39343343
45neuromuscular process controlling balance (GO:0050885)3.36466209
46L-amino acid import (GO:0043092)3.33273758
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.31637070
48positive regulation of synapse maturation (GO:0090129)3.30817229
49synaptic vesicle endocytosis (GO:0048488)3.30007197
50regulation of postsynaptic membrane potential (GO:0060078)3.29753601
51neuron-neuron synaptic transmission (GO:0007270)3.22594870
52regulation of T-helper 2 cell differentiation (GO:0045628)3.22420055
53potassium ion import (GO:0010107)3.21857237
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20871428
55cerebellar Purkinje cell differentiation (GO:0021702)3.19840707
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18591209
57regulation of dendritic spine morphogenesis (GO:0061001)3.18026949
58neurotransmitter transport (GO:0006836)3.14832727
59glycine transport (GO:0015816)3.12699194
60neuromuscular process controlling posture (GO:0050884)3.12013505
61cellular sodium ion homeostasis (GO:0006883)3.09912443
62chemosensory behavior (GO:0007635)3.09455266
63positive regulation of Rap GTPase activity (GO:0032854)3.07601531
64long-term synaptic potentiation (GO:0060291)3.03519160
65regulation of neurotransmitter levels (GO:0001505)3.01039199
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00596571
67regulation of neurotransmitter secretion (GO:0046928)3.00590690
68membrane depolarization during action potential (GO:0086010)2.99674925
69mannose metabolic process (GO:0006013)2.99055822
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98357932
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97918165
72regulation of clathrin-mediated endocytosis (GO:2000369)2.95031685
73amino acid import (GO:0043090)2.94416030
74membrane depolarization (GO:0051899)2.88435106
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84867271
76neuron cell-cell adhesion (GO:0007158)2.82340297
77regulation of vesicle fusion (GO:0031338)2.81784618
78alanine transport (GO:0032328)2.81720277
79dendrite morphogenesis (GO:0048813)2.81463427
80dendritic spine organization (GO:0097061)2.81217761
81positive regulation of protein dephosphorylation (GO:0035307)2.80206383
82vesicle transport along microtubule (GO:0047496)2.78623264
83regulation of synaptic transmission, glutamatergic (GO:0051966)2.77798540
84signal complex assembly (GO:0007172)2.76191386
85innervation (GO:0060384)2.76155521
86response to auditory stimulus (GO:0010996)2.75519820
87regulation of synapse maturation (GO:0090128)2.74049069
88regulation of neurotransmitter transport (GO:0051588)2.73636308
89regulation of ARF GTPase activity (GO:0032312)2.73634537
90long term synaptic depression (GO:0060292)2.72572710
91potassium ion homeostasis (GO:0055075)2.71601254
92regulation of voltage-gated calcium channel activity (GO:1901385)2.70639677
93regulation of dendritic spine development (GO:0060998)2.70453152
94positive regulation of fibroblast migration (GO:0010763)2.70343483
95positive regulation of dendritic spine development (GO:0060999)2.69425679
96regulation of synaptic transmission (GO:0050804)2.69162477
97positive regulation of synaptic transmission (GO:0050806)2.67156254
98cell communication involved in cardiac conduction (GO:0086065)2.66493590
99auditory behavior (GO:0031223)2.65519972
100positive regulation of neurotransmitter secretion (GO:0001956)2.65345610
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.64130316
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63247550
103neuromuscular process (GO:0050905)2.62711478
104transmission of nerve impulse (GO:0019226)2.62433488
105membrane hyperpolarization (GO:0060081)2.62250677
106regulation of ion transmembrane transporter activity (GO:0032412)2.61745918
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61592045
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.60963512
109neuronal ion channel clustering (GO:0045161)2.60338688
110positive regulation of neurotransmitter transport (GO:0051590)2.59241058
111adenosine receptor signaling pathway (GO:0001973)2.58774897
112protein localization to endosome (GO:0036010)2.58333653
113prepulse inhibition (GO:0060134)2.56755480
114regulation of Rap GTPase activity (GO:0032317)2.55489700
115membrane repolarization (GO:0086009)2.54943317
116macrophage activation involved in immune response (GO:0002281)2.53560747
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.48496258
118regulation of early endosome to late endosome transport (GO:2000641)2.46608939
119regulation of regulated secretory pathway (GO:1903305)2.45800752
120antigen processing and presentation of endogenous antigen (GO:0019883)2.44342206
121stress fiber assembly (GO:0043149)2.44321368
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40582759
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.32887784
124positive regulation of gamma-delta T cell activation (GO:0046645)2.30592450
125regulation of leukocyte degranulation (GO:0043300)2.30144692
126germinal center formation (GO:0002467)2.27662756
127protein targeting to plasma membrane (GO:0072661)2.26340019
128response to muramyl dipeptide (GO:0032495)2.22380792
129regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21335427
130negative regulation of type 2 immune response (GO:0002829)2.20739317
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.19645449
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.19645449
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.19645449
134modulation by symbiont of host immune response (GO:0052553)2.19645449
135positive regulation by symbiont of host defense response (GO:0052509)2.19645449
136modulation by symbiont of host defense response (GO:0052031)2.19645449
137negative regulation of toll-like receptor signaling pathway (GO:0034122)2.18376335
138regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.18123101
139actin filament capping (GO:0051693)2.16759111
140positive regulation of receptor recycling (GO:0001921)2.13982387
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.13175710
142regulation of type 2 immune response (GO:0002828)2.11894614
143positive regulation of type 2 immune response (GO:0002830)2.08906832
144barbed-end actin filament capping (GO:0051016)2.05122886
145activation of JUN kinase activity (GO:0007257)2.05079431
146regulation of mast cell degranulation (GO:0043304)2.05050464
147regulation of protein dephosphorylation (GO:0035304)2.04040434
148positive regulation of cellular amide metabolic process (GO:0034250)2.03703597
149cellular response to epinephrine stimulus (GO:0071872)2.03703280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79523180
2DROSHA_22980978_ChIP-Seq_HELA_Human2.92303295
3* RARB_27405468_Chip-Seq_BRAIN_Mouse2.71501223
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65876955
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65266946
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54495974
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49523561
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45174272
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42568444
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42568444
11REST_21632747_ChIP-Seq_MESCs_Mouse2.41283951
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39631014
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37039815
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33705626
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28474405
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22028436
17VDR_21846776_ChIP-Seq_THP-1_Human2.20103128
18GBX2_23144817_ChIP-Seq_PC3_Human2.13936707
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12177464
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11750796
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10246206
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09628743
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07973014
24TCF7_22412390_ChIP-Seq_EML_Mouse2.07511506
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.05821733
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.02378365
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.94200233
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.91934599
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85310358
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.81128066
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80977161
32RACK7_27058665_Chip-Seq_MCF-7_Human1.79841596
33P68_20966046_ChIP-Seq_HELA_Human1.69894821
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.68997683
35MYC_22102868_ChIP-Seq_BL_Human1.65293566
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64517420
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.61486626
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60436340
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60157456
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60136183
41KDM2B_26808549_Chip-Seq_K562_Human1.60118568
42VDR_24763502_ChIP-Seq_THP-1_Human1.58611632
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57268369
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55684878
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55195484
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52827373
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46253042
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.45766786
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45525252
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44434638
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42522250
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41453689
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.41310052
54MAF_26560356_Chip-Seq_TH1_Human1.38240170
55CREB1_26743006_Chip-Seq_LNCaP_Human1.36419652
56AR_21572438_ChIP-Seq_LNCaP_Human1.35044327
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33930060
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33352693
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33159265
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.32305158
61MAF_26560356_Chip-Seq_TH2_Human1.31316567
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30273012
63BCOR_27268052_Chip-Seq_Bcells_Human1.29316089
64SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27972077
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26270801
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.26132098
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26047027
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.25889755
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.25750059
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25698988
71LXR_22292898_ChIP-Seq_THP-1_Human1.25370652
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25342167
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23661346
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23603664
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22036982
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21959396
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21683475
78UTX_26944678_Chip-Seq_JUKART_Human1.20423003
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20275362
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20236168
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19609131
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19369855
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18924395
84BCL6_27268052_Chip-Seq_Bcells_Human1.17943902
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17627900
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.17129938
87GATA1_19941826_ChIP-Seq_K562_Human1.15982139
88* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15205153
89SMAD4_21799915_ChIP-Seq_A2780_Human1.14648935
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14357898
91AR_19668381_ChIP-Seq_PC3_Human1.13300044
92* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12574391
93KDM2B_26808549_Chip-Seq_DND41_Human1.10906119
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09921528
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.09031354
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.08815361
97TP63_22573176_ChIP-Seq_HFKS_Human1.07983822
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07586545
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06876758
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06772079
101SA1_27219007_Chip-Seq_Bcells_Human1.06540385
102RXR_22108803_ChIP-Seq_LS180_Human1.04796647
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04632134
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04443341
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03626860
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.03424052
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.01910788
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01591439
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01286641
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01221855
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00709241
112IRF8_22096565_ChIP-ChIP_GC-B_Human1.00214527
113CTCF_27219007_Chip-Seq_Bcells_Human0.97864449
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95941510
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.95786930
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95561706
117AHR_22903824_ChIP-Seq_MCF-7_Human0.95186917
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95167354
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95054348
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94561340
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.94426793
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94397271
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94064883
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.94058109
125SMC4_20622854_ChIP-Seq_HELA_Human0.93421224
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.92731527
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92286196
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92165972
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.91389780
130AR_25329375_ChIP-Seq_VCAP_Human0.91204225
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.88890366
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88312329
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85585188
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85413895
135KLF4_19829295_ChIP-Seq_ESCs_Human0.85331756
136ZNF274_21170338_ChIP-Seq_K562_Hela0.85080136
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84734386
138STAT3_23295773_ChIP-Seq_U87_Human0.84517362
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84074342
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83631201
141SPI1_23127762_ChIP-Seq_K562_Human0.83405895
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82859741
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.82605147
144* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81535688
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81482146
146ESR1_20079471_ChIP-ChIP_T-47D_Human0.81338579
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80791474
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80193804
149TP53_16413492_ChIP-PET_HCT116_Human0.80184346
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80167765
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79849207
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.79587433
153YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78251320
154OCT4_19829295_ChIP-Seq_ESCs_Human0.75757544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.72032579
2MP0003635_abnormal_synaptic_transmissio4.13866785
3MP0003880_abnormal_central_pattern3.79035698
4MP0004270_analgesia3.55494365
5MP0002063_abnormal_learning/memory/cond3.21247277
6MP0009745_abnormal_behavioral_response3.20392457
7MP0002064_seizures3.13414963
8MP0009046_muscle_twitch2.86952836
9MP0002822_catalepsy2.66605938
10MP0003705_abnormal_hypodermis_morpholog2.56216707
11MP0002572_abnormal_emotion/affect_behav2.53682816
12MP0001968_abnormal_touch/_nociception2.50013585
13MP0003436_decreased_susceptibility_to2.39118848
14MP0001501_abnormal_sleep_pattern2.36455337
15MP0002272_abnormal_nervous_system2.36158475
16MP0001486_abnormal_startle_reflex2.27567015
17MP0005423_abnormal_somatic_nervous2.26416338
18MP0002734_abnormal_mechanical_nocicepti2.21296080
19MP0004858_abnormal_nervous_system2.19823343
20MP0008569_lethality_at_weaning2.19553387
21MP0009780_abnormal_chondrocyte_physiolo2.16801836
22MP0003329_amyloid_beta_deposits2.10251572
23MP0002909_abnormal_adrenal_gland2.06633972
24MP0001440_abnormal_grooming_behavior1.97579303
25MP0004510_myositis1.92736588
26MP0002735_abnormal_chemical_nociception1.91117184
27MP0005409_darkened_coat_color1.88540361
28MP0003075_altered_response_to1.85705472
29MP0008260_abnormal_autophagy1.85323585
30MP0002736_abnormal_nociception_after1.85017725
31MP0001348_abnormal_lacrimal_gland1.82365053
32MP0005451_abnormal_body_composition1.81338394
33MP0004811_abnormal_neuron_physiology1.72608457
34MP0001970_abnormal_pain_threshold1.70141550
35MP0003879_abnormal_hair_cell1.69926911
36MP0002733_abnormal_thermal_nociception1.65826650
37MP0002067_abnormal_sensory_capabilities1.64749616
38MP0003633_abnormal_nervous_system1.61123187
39MP0008961_abnormal_basal_metabolism1.56137351
40MP0003724_increased_susceptibility_to1.54309829
41MP0000751_myopathy1.54026159
42MP0003191_abnormal_cellular_cholesterol1.51573624
43MP0000569_abnormal_digit_pigmentation1.50174209
44MP0001958_emphysema1.49902567
45MP0004924_abnormal_behavior1.44948665
46MP0005386_behavior/neurological_phenoty1.44948665
47MP0002557_abnormal_social/conspecific_i1.40150550
48MP0004947_skin_inflammation1.40040899
49MP0004885_abnormal_endolymph1.39577866
50MP0003172_abnormal_lysosome_physiology1.38633299
51MP0000604_amyloidosis1.38116779
52MP0003300_gastrointestinal_ulcer1.37237934
53MP0009840_abnormal_foam_cell1.34646175
54MP0003279_aneurysm1.33410056
55MP0003690_abnormal_glial_cell1.33117499
56MP0005167_abnormal_blood-brain_barrier1.32305043
57MP0002184_abnormal_innervation1.30746618
58MP0002066_abnormal_motor_capabilities/c1.28305582
59MP0002419_abnormal_innate_immunity1.27665362
60MP0000955_abnormal_spinal_cord1.27497432
61MP0005000_abnormal_immune_tolerance1.25574895
62MP0003091_abnormal_cell_migration1.24088985
63MP0003631_nervous_system_phenotype1.24081836
64MP0009278_abnormal_bone_marrow1.24057839
65MP0004130_abnormal_muscle_cell1.23323123
66MP0002837_dystrophic_cardiac_calcinosis1.22377751
67MP0005025_abnormal_response_to1.19001330
68MP0001533_abnormal_skeleton_physiology1.18435571
69MP0005646_abnormal_pituitary_gland1.18116166
70MP0002882_abnormal_neuron_morphology1.17442374
71MP0001502_abnormal_circadian_rhythm1.16155388
72MP0008874_decreased_physiological_sensi1.15879915
73MP0005464_abnormal_platelet_physiology1.12269872
74MP0005535_abnormal_body_temperature1.12208088
75MP0000778_abnormal_nervous_system1.11660322
76MP0002998_abnormal_bone_remodeling1.11550438
77MP0003787_abnormal_imprinting1.11131498
78MP0005387_immune_system_phenotype1.10582310
79MP0001790_abnormal_immune_system1.10582310
80MP0001835_abnormal_antigen_presentation1.10464668
81MP0006082_CNS_inflammation1.09950769
82MP0001849_ear_inflammation1.08576026
83MP0000678_abnormal_parathyroid_gland1.07473329
84MP0000685_abnormal_immune_system1.06129708
85MP0004145_abnormal_muscle_electrophysio1.03752955
86MP0003646_muscle_fatigue1.02036493
87MP0001984_abnormal_olfaction1.01386429
88MP0008872_abnormal_physiological_respon1.00646237
89MP0002090_abnormal_vision1.00634739
90MP0004215_abnormal_myocardial_fiber0.98053698
91MP0001986_abnormal_taste_sensitivity0.96767333
92MP0001851_eye_inflammation0.95034266
93MP0004085_abnormal_heartbeat0.94754859
94MP0002069_abnormal_eating/drinking_beha0.94216031
95MP0003283_abnormal_digestive_organ0.93939844
96MP0002723_abnormal_immune_serum0.92504646
97MP0003566_abnormal_cell_adhesion0.92336697
98MP0003828_pulmonary_edema0.91806363
99MP0002229_neurodegeneration0.91466250
100MP0000920_abnormal_myelination0.91088011
101MP0003303_peritoneal_inflammation0.90829686
102MP0000013_abnormal_adipose_tissue0.89341574
103MP0001800_abnormal_humoral_immune0.88148217
104MP0005076_abnormal_cell_differentiation0.87135602
105MP0003045_fibrosis0.86630440
106MP0004381_abnormal_hair_follicle0.86517900
107MP0002420_abnormal_adaptive_immunity0.86422890
108MP0005670_abnormal_white_adipose0.86421524
109MP0005375_adipose_tissue_phenotype0.86137192
110MP0003763_abnormal_thymus_physiology0.85352075
111MP0001819_abnormal_immune_cell0.85010493
112MP0004142_abnormal_muscle_tone0.84780047
113MP0000759_abnormal_skeletal_muscle0.84203796
114MP0003634_abnormal_glial_cell0.84013287
115MP0002152_abnormal_brain_morphology0.82843581
116MP0000003_abnormal_adipose_tissue0.82786114
117MP0005645_abnormal_hypothalamus_physiol0.82629876
118MP0008004_abnormal_stomach_pH0.81973764
119MP0004043_abnormal_pH_regulation0.81355116
120MP0005058_abnormal_lysosome_morphology0.80150842
121MP0005666_abnormal_adipose_tissue0.78980206
122MP0003632_abnormal_nervous_system0.77332826
123MP0002452_abnormal_antigen_presenting0.77003427
124MP0003866_abnormal_defecation0.76830457
125MP0001177_atelectasis0.76584488
126MP0002933_joint_inflammation0.75860139
127MP0003137_abnormal_impulse_conducting0.75774876
128MP0003453_abnormal_keratinocyte_physiol0.74724734
129MP0005410_abnormal_fertilization0.74555281
130MP0003183_abnormal_peptide_metabolism0.74002898
131MP0005623_abnormal_meninges_morphology0.73738507
132* MP0005166_decreased_susceptibility_to0.73378896
133MP0005551_abnormal_eye_electrophysiolog0.70976346
134MP0000747_muscle_weakness0.69919786
135MP0010234_abnormal_vibrissa_follicle0.69116514
136MP0004233_abnormal_muscle_weight0.67693717
137MP0001905_abnormal_dopamine_level0.67661171
138MP0004036_abnormal_muscle_relaxation0.66506662
139MP0001765_abnormal_ion_homeostasis0.65008492
140MP0010386_abnormal_urinary_bladder0.64584331
141MP0005310_abnormal_salivary_gland0.62012968
142MP0005620_abnormal_muscle_contractility0.57484141
143MP0006276_abnormal_autonomic_nervous0.57304643
144MP0005448_abnormal_energy_balance0.57295676
145MP0004087_abnormal_muscle_fiber0.56025758
146MP0000749_muscle_degeneration0.55230968
147* MP0004484_altered_response_of0.53601613
148MP0002972_abnormal_cardiac_muscle0.50530664
149MP0005584_abnormal_enzyme/coenzyme_acti0.50261574
150MP0001963_abnormal_hearing_physiology0.48348177
151MP0002078_abnormal_glucose_homeostasis0.47473653

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.06088119
2Focal motor seizures (HP:0011153)6.44559656
3Focal seizures (HP:0007359)5.20364934
4Visual hallucinations (HP:0002367)5.13111351
5Action tremor (HP:0002345)4.41394452
6Progressive cerebellar ataxia (HP:0002073)4.12958856
7Epileptic encephalopathy (HP:0200134)3.94398617
8Supranuclear gaze palsy (HP:0000605)3.92548832
9Atonic seizures (HP:0010819)3.71946619
10Febrile seizures (HP:0002373)3.67600511
11Absence seizures (HP:0002121)3.57825079
12Postural instability (HP:0002172)3.49019438
13Generalized tonic-clonic seizures (HP:0002069)3.44376726
14Ventricular fibrillation (HP:0001663)3.40242854
15Depression (HP:0000716)3.35970568
16Abnormality of the lower motor neuron (HP:0002366)3.31725132
17Impaired vibration sensation in the lower limbs (HP:0002166)3.28784653
18Dysmetria (HP:0001310)3.26537737
19Dialeptic seizures (HP:0011146)3.25115288
20Bundle branch block (HP:0011710)3.21262416
21Hemiplegia (HP:0002301)3.20737970
22Dysdiadochokinesis (HP:0002075)3.19713210
23Poor eye contact (HP:0000817)3.17861668
24Abnormal social behavior (HP:0012433)3.13938333
25Impaired social interactions (HP:0000735)3.13938333
26Ankle clonus (HP:0011448)3.09954075
27Gaze-evoked nystagmus (HP:0000640)3.05936918
28Urinary bladder sphincter dysfunction (HP:0002839)3.00054801
29Dysmetric saccades (HP:0000641)2.97030654
30Genetic anticipation (HP:0003743)2.96912425
31Mutism (HP:0002300)2.94238310
32Papilledema (HP:0001085)2.87906759
33Anxiety (HP:0000739)2.85137156
34Broad-based gait (HP:0002136)2.78142974
35Abnormal eating behavior (HP:0100738)2.77831300
36Eczematoid dermatitis (HP:0000976)2.76210372
37Intention tremor (HP:0002080)2.75626836
38Impaired smooth pursuit (HP:0007772)2.75298792
39Truncal ataxia (HP:0002078)2.71400057
40Torticollis (HP:0000473)2.63478592
41Cerebral aneurysm (HP:0004944)2.61301095
42Annular pancreas (HP:0001734)2.59328688
43Urinary urgency (HP:0000012)2.57665270
44Neurofibrillary tangles (HP:0002185)2.52321230
45Focal dystonia (HP:0004373)2.52288332
46Abnormality of binocular vision (HP:0011514)2.49015557
47Diplopia (HP:0000651)2.49015557
48Bradykinesia (HP:0002067)2.45641767
49Cerebral inclusion bodies (HP:0100314)2.45400680
50Asymmetric septal hypertrophy (HP:0001670)2.40920502
51Stereotypic behavior (HP:0000733)2.40477566
52Abnormality of ocular smooth pursuit (HP:0000617)2.40389169
53Status epilepticus (HP:0002133)2.35835460
54Increased variability in muscle fiber diameter (HP:0003557)2.35521873
55Pointed chin (HP:0000307)2.31969117
56Spastic gait (HP:0002064)2.31322051
57Amblyopia (HP:0000646)2.28885618
58Impaired vibratory sensation (HP:0002495)2.27900673
59Abnormality of the periventricular white matter (HP:0002518)2.26849091
60Megalencephaly (HP:0001355)2.26319125
61Insomnia (HP:0100785)2.25591168
62Dysostosis multiplex (HP:0000943)2.24398964
63Distal lower limb amyotrophy (HP:0008944)2.23806217
64Slow saccadic eye movements (HP:0000514)2.23761977
65Hemiparesis (HP:0001269)2.23327534
66Scanning speech (HP:0002168)2.21082647
67Rapidly progressive (HP:0003678)2.20816252
68Abnormality of skeletal muscle fiber size (HP:0012084)2.18383998
69Sudden death (HP:0001699)2.18049348
70Hyperventilation (HP:0002883)2.17313919
71Broad face (HP:0000283)2.16856793
72Exercise-induced myalgia (HP:0003738)2.16332604
73Abnormal EKG (HP:0003115)2.14698786
74Peripheral hypomyelination (HP:0007182)2.13818992
75Craniofacial dystonia (HP:0012179)2.13455017
76Neuronal loss in central nervous system (HP:0002529)2.12833831
77Tetraplegia (HP:0002445)2.11999948
78Abnormality of macrophages (HP:0004311)2.11500889
79Progressive inability to walk (HP:0002505)2.11277491
80Abnormality of saccadic eye movements (HP:0000570)2.11253046
81Centrally nucleated skeletal muscle fibers (HP:0003687)2.11206717
82Hand muscle atrophy (HP:0009130)2.08908225
83Increased connective tissue (HP:0009025)2.06799115
84Urinary glycosaminoglycan excretion (HP:0003541)2.06211343
85Mucopolysacchariduria (HP:0008155)2.06211343
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06116831
87Abnormality of polysaccharide metabolism (HP:0011012)2.06116831
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06116831
89Akinesia (HP:0002304)2.05861456
90Syncope (HP:0001279)2.04857383
91Myopathic facies (HP:0002058)2.03899261
92Lower limb amyotrophy (HP:0007210)2.03565213
93Thin bony cortex (HP:0002753)2.03154484
94Prolonged QT interval (HP:0001657)2.02663200
95Obstructive sleep apnea (HP:0002870)2.02448662
96Distal lower limb muscle weakness (HP:0009053)2.02175266
97Protrusio acetabuli (HP:0003179)2.01626196
98Rigidity (HP:0002063)2.00556485
99Stridor (HP:0010307)1.98552539
100Drooling (HP:0002307)1.98170081
101Excessive salivation (HP:0003781)1.98170081
102Lower limb asymmetry (HP:0100559)1.98161589
103Axonal loss (HP:0003447)1.97101452
104Hyporeflexia of lower limbs (HP:0002600)1.96754296
105Myositis (HP:0100614)1.95660578
106Epileptiform EEG discharges (HP:0011182)1.94802558
107Lower limb muscle weakness (HP:0007340)1.94300690
108Achilles tendon contracture (HP:0001771)1.93711534
109Cellulitis (HP:0100658)1.92599638
110Global brain atrophy (HP:0002283)1.91117875
111Increased IgE level (HP:0003212)1.90722583
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89107186
113Heart block (HP:0012722)1.88208293
114EEG with generalized epileptiform discharges (HP:0011198)1.87974591
115Hypercortisolism (HP:0001578)1.86447150
116Amyloidosis (HP:0011034)1.86418777
117Hyperacusis (HP:0010780)1.85322168
118Type 1 muscle fiber predominance (HP:0003803)1.84849537
119Prolonged bleeding time (HP:0003010)1.84574480
120Spinal canal stenosis (HP:0003416)1.84231004
121Apathy (HP:0000741)1.83054872
122Hypsarrhythmia (HP:0002521)1.82475478
123Gingivitis (HP:0000230)1.81899285
124Psychosis (HP:0000709)1.81711156
125Abnormality of the Achilles tendon (HP:0005109)1.81386148
126Ventricular arrhythmia (HP:0004308)1.81143477
127Gait ataxia (HP:0002066)1.80602776
128Generalized myoclonic seizures (HP:0002123)1.80109977
129Onion bulb formation (HP:0003383)1.79492699
130Distal upper limb amyotrophy (HP:0007149)1.78826931
131Upper limb amyotrophy (HP:0009129)1.78826931
132Gastrointestinal infarctions (HP:0005244)1.77428655
133Orchitis (HP:0100796)1.77128065
134Incomplete penetrance (HP:0003829)1.76801128
135Recurrent abscess formation (HP:0002722)1.76559908
136Emphysema (HP:0002097)1.75989832
137Termporal pattern (HP:0011008)1.75925986
138Insidious onset (HP:0003587)1.75925986
139Ocular albinism (HP:0001107)1.75750371
140Agitation (HP:0000713)1.75431178
141Difficulty running (HP:0009046)1.74546919
142Muscle fiber splitting (HP:0003555)1.74230396
143Increased cerebral lipofuscin (HP:0011813)1.74227435
144Spastic tetraparesis (HP:0001285)1.73293539
145Diminished motivation (HP:0000745)1.72474932
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72125144
147Anosmia (HP:0000458)1.72055151
148Abnormal atrioventricular conduction (HP:0005150)1.71871715
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71408516
150Hemorrhage of the eye (HP:0011885)1.70159327
151Aneurysm (HP:0002617)1.70149157
152Spontaneous hematomas (HP:0007420)1.67994334
153Foot dorsiflexor weakness (HP:0009027)1.66450693
154Segmental peripheral demyelination/remyelination (HP:0003481)1.65275850
155Dementia (HP:0000726)1.64341843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.91038719
2MAP3K93.89643440
3EPHA43.84883179
4DAPK22.96931784
5PRKD32.81577512
6KSR22.54419187
7PAK62.47303733
8ERN12.44102644
9MINK12.35386575
10CAMKK12.34728545
11RIPK42.31026014
12MAP3K42.22102755
13MAP3K131.97444187
14STK381.78211139
15MAP4K11.67599258
16MAP2K31.63699200
17NTRK11.62868458
18MARK11.62409143
19NTRK21.59661486
20MAP2K41.58875337
21SIK11.54654416
22MAP3K111.54281608
23SIK21.54162354
24RIPK11.52526981
25CDK51.49365687
26DAPK11.46987488
27TAOK11.43115378
28MAP2K71.42557205
29KSR11.42128012
30PRPF4B1.40016201
31FES1.39309060
32MAP3K21.35962715
33LMTK21.30556742
34CAMK11.26810321
35EPHB11.24070185
36ZAP701.23162973
37PRKCH1.22773138
38CDK121.21209621
39TYRO31.19134128
40TESK11.18664628
41CAMK1G1.17688071
42TRIB31.17585028
43SMG11.17570102
44MAP3K71.17217099
45PTK2B1.13745911
46PHKG21.12020765
47PHKG11.12020765
48GRK51.10233317
49ARAF1.10131270
50CAMKK21.09107051
51PDK11.07745045
52DMPK1.02374392
53TYK21.01128549
54PRKCG1.00569151
55TTN0.99772826
56ALK0.99641281
57STK110.99151036
58RET0.97920959
59BLK0.96824835
60TAOK20.96727590
61PDPK10.95851573
62SGK30.95838520
63CDK190.92648797
64MAP3K120.92349320
65PINK10.90849569
66MAP3K30.90398647
67MAP3K10.89240614
68FGFR40.84143384
69SGK2230.82055363
70SGK4940.82055363
71GRK60.81447924
72CAMK40.80883396
73UHMK10.80539221
74CAMK2A0.77317409
75EEF2K0.77251807
76PLK20.76599075
77RAF10.75948246
78SIK30.75480261
79CDK150.74524060
80MARK20.74427373
81CSK0.73654769
82CDK180.73552932
83PAK30.73148706
84CDC42BPA0.72868803
85HIPK20.72165471
86SGK20.71225017
87SGK10.71083420
88TBK10.70122747
89CAMK1D0.67049552
90TNIK0.65662811
91CDK11A0.64510803
92MAPK70.64457528
93MAP2K60.64148751
94CDK140.63256661
95PRKG20.62858495
96HCK0.59680224
97JAK10.59556780
98CAMK2B0.59515350
99TNK20.58242508
100IRAK20.58032795
101IRAK30.57492404
102SYK0.56443706
103FYN0.56188061
104WNK10.54947024
105BRAF0.54241485
106DAPK30.54201913
107NEK60.53582277
108MOS0.53382801
109MAP3K140.53001063
110RPS6KA30.52597003
111MAPK110.50847309
112JAK30.50525985
113PRKCZ0.49681210
114MAPK120.49201929
115BMX0.48811455
116MAP3K60.47934685
117IRAK40.47004321
118DYRK1B0.46924793
119LATS20.46024788
120CAMK2D0.45531202
121PKN20.45303869
122MAPK130.44881648
123RPS6KC10.44824130
124FGR0.44810195
125MAP2K10.41902105
126MAPK100.41637868
127CAMK2G0.41458750
128JAK20.41285037
129NEK10.41015703
130DYRK1A0.40428618
131ICK0.40054609
132PDGFRA0.38849091
133RPS6KA20.37301211
134PNCK0.34793622
135PRKD20.34616331
136PRKD10.34093095
137DDR20.33892303
138FER0.32624101
139BMPR20.31819794

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.75791521
2Nicotine addiction_Homo sapiens_hsa050332.65096734
3Olfactory transduction_Homo sapiens_hsa047402.51038946
4Long-term potentiation_Homo sapiens_hsa047202.42174614
5Circadian entrainment_Homo sapiens_hsa047132.38459084
6Glutamatergic synapse_Homo sapiens_hsa047242.23793176
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17556485
8GABAergic synapse_Homo sapiens_hsa047272.15438592
9Nitrogen metabolism_Homo sapiens_hsa009102.13758682
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11737031
11Salivary secretion_Homo sapiens_hsa049702.09143406
12Amphetamine addiction_Homo sapiens_hsa050312.02160179
13Morphine addiction_Homo sapiens_hsa050321.99285224
14Insulin secretion_Homo sapiens_hsa049111.95691320
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93387757
16Gastric acid secretion_Homo sapiens_hsa049711.92592675
17Cholinergic synapse_Homo sapiens_hsa047251.73437795
18Dopaminergic synapse_Homo sapiens_hsa047281.68879920
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67816594
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64866987
21Oxytocin signaling pathway_Homo sapiens_hsa049211.58746334
22Type II diabetes mellitus_Homo sapiens_hsa049301.54435860
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45890680
24Calcium signaling pathway_Homo sapiens_hsa040201.44578880
25GnRH signaling pathway_Homo sapiens_hsa049121.42690501
26Renin secretion_Homo sapiens_hsa049241.41499343
27Long-term depression_Homo sapiens_hsa047301.32026293
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26442776
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25202917
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23759142
31Acute myeloid leukemia_Homo sapiens_hsa052211.22474449
32cAMP signaling pathway_Homo sapiens_hsa040241.21799781
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21270252
34Glioma_Homo sapiens_hsa052141.19917104
35Cocaine addiction_Homo sapiens_hsa050301.19299673
36Taste transduction_Homo sapiens_hsa047421.17474244
37Other glycan degradation_Homo sapiens_hsa005111.16653236
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13756896
39Estrogen signaling pathway_Homo sapiens_hsa049151.08130406
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07702374
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07122998
42Gap junction_Homo sapiens_hsa045401.06627672
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.05277931
44Serotonergic synapse_Homo sapiens_hsa047261.02474479
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01466668
46Pancreatic secretion_Homo sapiens_hsa049720.93144346
47ErbB signaling pathway_Homo sapiens_hsa040120.91920584
48Leishmaniasis_Homo sapiens_hsa051400.91520484
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91491227
50Dorso-ventral axis formation_Homo sapiens_hsa043200.90580340
51Dilated cardiomyopathy_Homo sapiens_hsa054140.90509483
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.90457034
53Bile secretion_Homo sapiens_hsa049760.89557946
54Chronic myeloid leukemia_Homo sapiens_hsa052200.88087554
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.87291106
56T cell receptor signaling pathway_Homo sapiens_hsa046600.87071523
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86149571
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84919084
59Collecting duct acid secretion_Homo sapiens_hsa049660.84667831
60VEGF signaling pathway_Homo sapiens_hsa043700.84063570
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83415024
62Melanogenesis_Homo sapiens_hsa049160.80699920
63Cardiac muscle contraction_Homo sapiens_hsa042600.80213131
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.78065468
65Thyroid hormone synthesis_Homo sapiens_hsa049180.77173782
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76815226
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.76619562
68Notch signaling pathway_Homo sapiens_hsa043300.76438767
69Choline metabolism in cancer_Homo sapiens_hsa052310.72360839
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71738531
71Amoebiasis_Homo sapiens_hsa051460.71573191
72Glucagon signaling pathway_Homo sapiens_hsa049220.70583116
73Arginine biosynthesis_Homo sapiens_hsa002200.70471195
74mTOR signaling pathway_Homo sapiens_hsa041500.69457693
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67721613
76TNF signaling pathway_Homo sapiens_hsa046680.67464788
77Toxoplasmosis_Homo sapiens_hsa051450.66717471
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66403664
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66198444
80Axon guidance_Homo sapiens_hsa043600.65542082
81MAPK signaling pathway_Homo sapiens_hsa040100.63865017
82Endocytosis_Homo sapiens_hsa041440.62327785
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61954342
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61907690
85Lysosome_Homo sapiens_hsa041420.60661523
86Pancreatic cancer_Homo sapiens_hsa052120.60062075
87Inositol phosphate metabolism_Homo sapiens_hsa005620.58890832
88Hepatitis C_Homo sapiens_hsa051600.58743606
89African trypanosomiasis_Homo sapiens_hsa051430.57517998
90Focal adhesion_Homo sapiens_hsa045100.57452201
91Non-small cell lung cancer_Homo sapiens_hsa052230.57437460
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56177893
93Chemokine signaling pathway_Homo sapiens_hsa040620.55993750
94HIF-1 signaling pathway_Homo sapiens_hsa040660.55219898
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.54815686
96Rap1 signaling pathway_Homo sapiens_hsa040150.54804084
97Insulin signaling pathway_Homo sapiens_hsa049100.54326573
98Pertussis_Homo sapiens_hsa051330.53825048
99AMPK signaling pathway_Homo sapiens_hsa041520.53276496
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53187163
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51969994
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50906607
103Prion diseases_Homo sapiens_hsa050200.48707697
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.47468240
105Vibrio cholerae infection_Homo sapiens_hsa051100.47345392
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46280392
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45191624
108Ras signaling pathway_Homo sapiens_hsa040140.43543971
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43159239
110Oocyte meiosis_Homo sapiens_hsa041140.42767464
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41318674
112Insulin resistance_Homo sapiens_hsa049310.40942867
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40776604
114Circadian rhythm_Homo sapiens_hsa047100.40771736
115Renal cell carcinoma_Homo sapiens_hsa052110.40365783
116Endometrial cancer_Homo sapiens_hsa052130.39891770
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39561971
118B cell receptor signaling pathway_Homo sapiens_hsa046620.39147524
119Type I diabetes mellitus_Homo sapiens_hsa049400.37427699
120Platelet activation_Homo sapiens_hsa046110.37098784
121Tuberculosis_Homo sapiens_hsa051520.34659373
122Osteoclast differentiation_Homo sapiens_hsa043800.34480667
123Phototransduction_Homo sapiens_hsa047440.34366446
124Prolactin signaling pathway_Homo sapiens_hsa049170.32213917

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