CAND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.44608028
2nuclear pore complex assembly (GO:0051292)5.35676613
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.74236747
4regulation of translational termination (GO:0006449)4.67532766
5regulation of spindle organization (GO:0090224)4.62203699
6mitotic metaphase plate congression (GO:0007080)4.57740435
7protein localization to kinetochore (GO:0034501)4.51490802
8pre-miRNA processing (GO:0031054)4.44455179
9mitotic nuclear envelope disassembly (GO:0007077)4.41676155
10nuclear envelope disassembly (GO:0051081)4.30367834
11membrane disassembly (GO:0030397)4.30367834
12regulation of RNA export from nucleus (GO:0046831)4.23970437
13nucleobase biosynthetic process (GO:0046112)4.06137169
14purine nucleobase biosynthetic process (GO:0009113)4.02572278
15positive regulation of chromosome segregation (GO:0051984)3.97181554
16pore complex assembly (GO:0046931)3.96404103
17regulation of mitotic spindle organization (GO:0060236)3.95050503
18ribosome assembly (GO:0042255)3.90496439
19DNA replication-dependent nucleosome assembly (GO:0006335)3.86486184
20DNA replication-dependent nucleosome organization (GO:0034723)3.86486184
21protein localization to chromosome, centromeric region (GO:0071459)3.84853670
22negative regulation of histone methylation (GO:0031061)3.80667804
23histone H2A monoubiquitination (GO:0035518)3.79072324
24monoubiquitinated protein deubiquitination (GO:0035520)3.78834509
25mitotic sister chromatid cohesion (GO:0007064)3.75923724
26sister chromatid segregation (GO:0000819)3.72675883
27mitotic chromosome condensation (GO:0007076)3.72304927
28metaphase plate congression (GO:0051310)3.70820237
29mitotic sister chromatid segregation (GO:0000070)3.68840095
30DNA unwinding involved in DNA replication (GO:0006268)3.61242846
31nuclear envelope organization (GO:0006998)3.54796844
32regulation of sister chromatid cohesion (GO:0007063)3.53319601
33regulation of chromosome segregation (GO:0051983)3.52676998
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.48990592
35heterochromatin organization (GO:0070828)3.43759486
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42546264
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42546264
38positive regulation of mitotic sister chromatid separation (GO:1901970)3.42546264
39regulation of nucleobase-containing compound transport (GO:0032239)3.35177548
40regulation of histone H3-K9 methylation (GO:0051570)3.34679024
41formation of translation preinitiation complex (GO:0001731)3.28184821
42protein localization to chromosome (GO:0034502)3.26699565
43negative regulation of DNA repair (GO:0045738)3.23080630
44DNA replication checkpoint (GO:0000076)3.22196790
45spindle checkpoint (GO:0031577)3.21081980
46regulation of centrosome cycle (GO:0046605)3.19746312
47regulation of centriole replication (GO:0046599)3.18574150
48double-strand break repair via nonhomologous end joining (GO:0006303)3.17868370
49non-recombinational repair (GO:0000726)3.17868370
50spindle assembly involved in mitosis (GO:0090307)3.17198271
51mitotic spindle checkpoint (GO:0071174)3.13908746
52negative regulation of chromosome segregation (GO:0051985)3.13056069
53gene silencing by RNA (GO:0031047)3.11390713
54folic acid-containing compound biosynthetic process (GO:0009396)3.11006751
55peptidyl-arginine omega-N-methylation (GO:0035247)3.10732599
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10588151
57establishment of chromosome localization (GO:0051303)3.10326232
58ribosome biogenesis (GO:0042254)3.06612138
59synaptonemal complex assembly (GO:0007130)3.05811602
60microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.04937468
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04503215
62mitotic spindle assembly checkpoint (GO:0007094)3.04446098
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04312422
64negative regulation of sister chromatid segregation (GO:0033046)3.04312422
65negative regulation of mitotic sister chromatid separation (GO:2000816)3.04312422
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04312422
67spindle assembly checkpoint (GO:0071173)3.03039643
68chaperone-mediated protein complex assembly (GO:0051131)3.02925660
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02587619
70paraxial mesoderm development (GO:0048339)3.02485730
71DNA topological change (GO:0006265)3.02178164
72IMP biosynthetic process (GO:0006188)3.01913800
73DNA replication initiation (GO:0006270)3.01364694
74NLS-bearing protein import into nucleus (GO:0006607)3.01239512
75peptidyl-arginine methylation (GO:0018216)3.00692087
76peptidyl-arginine N-methylation (GO:0035246)3.00692087
77regulation of centrosome duplication (GO:0010824)3.00429721
78histone-serine phosphorylation (GO:0035404)3.00397397
79mitotic spindle organization (GO:0007052)2.97724325
80positive regulation of dendritic spine morphogenesis (GO:0061003)2.96999865
81regulation of sister chromatid segregation (GO:0033045)2.96556231
82regulation of mitotic sister chromatid separation (GO:0010965)2.96556231
83regulation of mitotic sister chromatid segregation (GO:0033047)2.96556231
84regulation of DNA endoreduplication (GO:0032875)2.96548791
85folic acid metabolic process (GO:0046655)2.94882082
86negative regulation of fibroblast apoptotic process (GO:2000270)2.94820205
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94143373
88DNA duplex unwinding (GO:0032508)2.93493327
89attachment of spindle microtubules to kinetochore (GO:0008608)2.92929791
90chromatin remodeling at centromere (GO:0031055)2.92858257
91DNA geometric change (GO:0032392)2.91546193
92peptidyl-lysine dimethylation (GO:0018027)2.90398975
93CENP-A containing nucleosome assembly (GO:0034080)2.89795765
94chromatin assembly (GO:0031497)2.89086193
95DNA strand elongation involved in DNA replication (GO:0006271)2.84996375
96chromatin assembly or disassembly (GO:0006333)2.83518421
97chromosome condensation (GO:0030261)2.83226897
98lung-associated mesenchyme development (GO:0060484)2.82486652
99DNA strand elongation (GO:0022616)2.81536770
100mitotic G1 DNA damage checkpoint (GO:0031571)2.81415583
101IMP metabolic process (GO:0046040)2.79181149
102regulation of gene silencing by miRNA (GO:0060964)2.78832460
103regulation of gene silencing by RNA (GO:0060966)2.78832460
104regulation of posttranscriptional gene silencing (GO:0060147)2.78832460
105histone exchange (GO:0043486)2.77701023
106histone H2A ubiquitination (GO:0033522)2.76842962
107ATP-dependent chromatin remodeling (GO:0043044)2.75406086
108spliceosomal tri-snRNP complex assembly (GO:0000244)2.75236795
109histone arginine methylation (GO:0034969)2.74263853
110sister chromatid cohesion (GO:0007062)2.73606738
111synaptonemal complex organization (GO:0070193)2.73345347
112mRNA transport (GO:0051028)2.73228076
113regulation of translational fidelity (GO:0006450)2.72530649
114meiotic chromosome segregation (GO:0045132)2.66391030
115microtubule anchoring (GO:0034453)2.66377156
116microtubule depolymerization (GO:0007019)2.62319074
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.62189707
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62189707
119DNA double-strand break processing (GO:0000729)2.61210606
120kinetochore organization (GO:0051383)2.60412022
121positive regulation of cell cycle checkpoint (GO:1901978)2.57471317
122mitotic cytokinesis (GO:0000281)2.53342147
123presynaptic membrane assembly (GO:0097105)2.48878617
124DNA conformation change (GO:0071103)2.47521537
125DNA replication-independent nucleosome assembly (GO:0006336)2.46644024
126DNA replication-independent nucleosome organization (GO:0034724)2.46644024
127DNA ligation (GO:0006266)2.45193934
128dorsal/ventral axis specification (GO:0009950)2.44505951
129positive regulation of cell cycle G2/M phase transition (GO:1902751)2.43706483
130positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.43706483
131protein complex localization (GO:0031503)2.41277630
132chromosome segregation (GO:0007059)2.41149949
133spindle organization (GO:0007051)2.39187279
134gastrulation with mouth forming second (GO:0001702)2.37937483
135embryonic foregut morphogenesis (GO:0048617)2.35214317
136histone H2A acetylation (GO:0043968)2.33531376
137ectodermal placode formation (GO:0060788)2.32605108
138mitotic recombination (GO:0006312)2.32419690
139establishment of integrated proviral latency (GO:0075713)2.32408786
140cellular protein complex localization (GO:0034629)2.28373254
141telomere maintenance via semi-conservative replication (GO:0032201)2.28235985
142DNA packaging (GO:0006323)2.27657545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.62714652
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.63713609
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.69351740
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60599823
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.60252745
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.20447005
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.15198213
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.10160703
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04586480
10AR_21909140_ChIP-Seq_LNCAP_Human2.98340426
11* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91449562
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41453017
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39062282
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22233486
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18072100
16MYCN_18555785_ChIP-Seq_MESCs_Mouse2.15859090
17FUS_26573619_Chip-Seq_HEK293_Human2.15240702
18* E2F1_21310950_ChIP-Seq_MCF-7_Human2.07081820
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98915279
20EWS_26573619_Chip-Seq_HEK293_Human1.97738662
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95894446
22* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95830934
23ZNF263_19887448_ChIP-Seq_K562_Human1.95171997
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94521290
25* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.92751775
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91016049
27XRN2_22483619_ChIP-Seq_HELA_Human1.90324022
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90320052
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88278557
30TAF15_26573619_Chip-Seq_HEK293_Human1.87624655
31* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.86270447
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81488908
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.81300392
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80940193
35MYC_22102868_ChIP-Seq_BL_Human1.77407664
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76703897
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76681110
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73631656
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73184053
40GBX2_23144817_ChIP-Seq_PC3_Human1.71587778
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.67637515
42KDM5A_27292631_Chip-Seq_BREAST_Human1.64084649
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62280659
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62186664
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.59767494
46ELK1_19687146_ChIP-ChIP_HELA_Human1.56743225
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56608217
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54857852
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54690215
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54120176
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54009426
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.53988396
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50432855
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50326694
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49876955
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47780837
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46516961
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46483475
59GABP_19822575_ChIP-Seq_HepG2_Human1.45063720
60IGF1R_20145208_ChIP-Seq_DFB_Human1.44798082
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44741510
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.43713205
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42937515
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42623964
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41899294
66CIITA_25753668_ChIP-Seq_RAJI_Human1.38465863
67* EST1_17652178_ChIP-ChIP_JURKAT_Human1.38329740
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38185827
69* TTF2_22483619_ChIP-Seq_HELA_Human1.36055131
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35519243
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34323813
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33018108
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32924363
74* VDR_23849224_ChIP-Seq_CD4+_Human1.30109407
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28967599
76SOX9_26525672_Chip-Seq_HEART_Mouse1.28964932
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25446978
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24817515
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24762440
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24175363
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24163742
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.22592249
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22512273
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21530486
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21143643
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20861942
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20534308
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20104048
89CHD1_26751641_Chip-Seq_LNCaP_Human1.19217831
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.17160350
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16291312
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16082390
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14603083
94DCP1A_22483619_ChIP-Seq_HELA_Human1.14164650
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14133543
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.14007846
97FOXP3_21729870_ChIP-Seq_TREG_Human1.13778344
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11683290
99P300_19829295_ChIP-Seq_ESCs_Human1.10557770
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09353935
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09191119
102* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08749422
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08188119
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07980138
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07712854
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07341271
107TFEB_21752829_ChIP-Seq_HELA_Human1.06064983
108ZNF274_21170338_ChIP-Seq_K562_Hela1.05855476
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05630727
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05194431
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05130541
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.04344216
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04030742
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04000422
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03729852
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02782209
117SMAD4_21799915_ChIP-Seq_A2780_Human1.01742933
118* ATF3_27146783_Chip-Seq_COLON_Human1.01374522
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99336032
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97747172
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97593763
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97413215
123* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97358327
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.96993935
125MYC_18940864_ChIP-ChIP_HL60_Human0.96646257
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95967663
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95452349
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95424422
129SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94650236
130SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93343369
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93149096
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.92954464
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92748622
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92748622
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92748622
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92432134
137* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90470879
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89742624
139STAT3_23295773_ChIP-Seq_U87_Human0.89418679
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.88959570
141* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88372412
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88187274
143* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88073325
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.88060185
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87972565
146* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86612253
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.84823311
148* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83711635
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83089672
150REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82207168
151ISL1_27105846_Chip-Seq_CPCs_Mouse0.81747778
152IRF1_19129219_ChIP-ChIP_H3396_Human0.80374024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.94472919
2MP0003111_abnormal_nucleus_morphology3.79215584
3MP0003123_paternal_imprinting3.65492618
4MP0004957_abnormal_blastocyst_morpholog3.51315797
5MP0010094_abnormal_chromosome_stability3.34981765
6MP0003077_abnormal_cell_cycle3.05997839
7MP0010352_gastrointestinal_tract_polyps2.85740497
8MP0008057_abnormal_DNA_replication2.78890767
9MP0001730_embryonic_growth_arrest2.64983213
10MP0003705_abnormal_hypodermis_morpholog2.61289883
11MP0008877_abnormal_DNA_methylation2.42490272
12MP0002009_preneoplasia2.41597110
13MP0010307_abnormal_tumor_latency2.39639828
14MP0000537_abnormal_urethra_morphology2.32320278
15MP0005076_abnormal_cell_differentiation2.31049861
16MP0000350_abnormal_cell_proliferation2.18213510
17MP0002084_abnormal_developmental_patter2.17609209
18MP0003121_genomic_imprinting2.14093055
19MP0005380_embryogenesis_phenotype2.07178002
20MP0001672_abnormal_embryogenesis/_devel2.07178002
21MP0008932_abnormal_embryonic_tissue1.95404573
22MP0001697_abnormal_embryo_size1.93602289
23MP0002085_abnormal_embryonic_tissue1.92856985
24MP0008058_abnormal_DNA_repair1.92595960
25MP0008007_abnormal_cellular_replicative1.92053450
26MP0009697_abnormal_copulation1.90823500
27MP0004197_abnormal_fetal_growth/weight/1.86506566
28MP0003984_embryonic_growth_retardation1.82768390
29MP0002088_abnormal_embryonic_growth/wei1.81511737
30MP0010234_abnormal_vibrissa_follicle1.79852074
31MP0002086_abnormal_extraembryonic_tissu1.76670843
32MP0003890_abnormal_embryonic-extraembry1.76037245
33MP0002080_prenatal_lethality1.69662750
34MP0003119_abnormal_digestive_system1.67849100
35MP0002653_abnormal_ependyma_morphology1.64722903
36MP0005623_abnormal_meninges_morphology1.62290219
37MP0009053_abnormal_anal_canal1.62150400
38MP0003283_abnormal_digestive_organ1.57014250
39MP0000778_abnormal_nervous_system1.56716783
40MP0003122_maternal_imprinting1.53114949
41MP0000566_synostosis1.52529274
42MP0010678_abnormal_skin_adnexa1.50641851
43MP0001849_ear_inflammation1.49835891
44MP0003937_abnormal_limbs/digits/tail_de1.47509497
45MP0009672_abnormal_birth_weight1.47376813
46MP0000428_abnormal_craniofacial_morphol1.47297460
47MP0009703_decreased_birth_body1.46040215
48MP0005187_abnormal_penis_morphology1.45275046
49MP0002210_abnormal_sex_determination1.37491791
50MP0000383_abnormal_hair_follicle1.35416466
51MP0003718_maternal_effect1.33496640
52MP0010030_abnormal_orbit_morphology1.31907357
53MP0002877_abnormal_melanocyte_morpholog1.31064473
54MP0001293_anophthalmia1.29032463
55MP0001177_atelectasis1.28148617
56MP0001929_abnormal_gametogenesis1.27741042
57MP0003115_abnormal_respiratory_system1.27659958
58MP0003567_abnormal_fetal_cardiomyocyte1.27418975
59MP0005248_abnormal_Harderian_gland1.26224211
60MP0001145_abnormal_male_reproductive1.24607070
61MP0003786_premature_aging1.24011552
62MP0000569_abnormal_digit_pigmentation1.23789098
63MP0004233_abnormal_muscle_weight1.23764405
64MP0004808_abnormal_hematopoietic_stem1.13612929
65MP0003935_abnormal_craniofacial_develop1.13577040
66MP0003861_abnormal_nervous_system1.12663467
67MP0002751_abnormal_autonomic_nervous1.12191385
68MP0001299_abnormal_eye_distance/1.10561009
69MP0000733_abnormal_muscle_development1.09836636
70MP0003221_abnormal_cardiomyocyte_apopto1.09612522
71MP0000653_abnormal_sex_gland1.08743360
72MP0005171_absent_coat_pigmentation1.06313657
73MP0001346_abnormal_lacrimal_gland1.05799291
74MP0000647_abnormal_sebaceous_gland1.05252982
75MP0002092_abnormal_eye_morphology1.04165883
76MP0000579_abnormal_nail_morphology1.03229319
77MP0002184_abnormal_innervation1.02487084
78MP0002111_abnormal_tail_morphology1.00740084
79MP0000427_abnormal_hair_cycle0.98448696
80MP0003755_abnormal_palate_morphology0.98253963
81MP0003698_abnormal_male_reproductive0.97721516
82MP0000534_abnormal_ureter_morphology0.97294898
83MP0002822_catalepsy0.94430259
84MP0003315_abnormal_perineum_morphology0.93614189
85MP0002098_abnormal_vibrissa_morphology0.93239192
86MP0000432_abnormal_head_morphology0.93195527
87MP0004270_analgesia0.92028100
88MP0000049_abnormal_middle_ear0.91038622
89MP0004185_abnormal_adipocyte_glucose0.86992639
90MP0003787_abnormal_imprinting0.86940584
91MP0000313_abnormal_cell_death0.85832855
92MP0002152_abnormal_brain_morphology0.83821282
93MP0002697_abnormal_eye_size0.83554603
94MP0000955_abnormal_spinal_cord0.83225928
95MP0003942_abnormal_urinary_system0.82889231
96MP0003943_abnormal_hepatobiliary_system0.82864608
97MP0002161_abnormal_fertility/fecundity0.82161389
98MP0002938_white_spotting0.81295812
99MP0005621_abnormal_cell_physiology0.81059921
100MP0002234_abnormal_pharynx_morphology0.80986319
101MP0001915_intracranial_hemorrhage0.80715601
102MP0003566_abnormal_cell_adhesion0.80578683
103MP0005384_cellular_phenotype0.80210128
104MP0005391_vision/eye_phenotype0.80166584
105MP0002160_abnormal_reproductive_system0.80151867
106MP0008770_decreased_survivor_rate0.79233677
107MP0001529_abnormal_vocalization0.78698301
108MP0000358_abnormal_cell_content/0.78541329
109MP0002177_abnormal_outer_ear0.77439650
110MP0005394_taste/olfaction_phenotype0.76121315
111MP0005499_abnormal_olfactory_system0.76121315
112MP0003880_abnormal_central_pattern0.73778767
113MP0003941_abnormal_skin_development0.72658287
114MP0000631_abnormal_neuroendocrine_gland0.72539911
115MP0002925_abnormal_cardiovascular_devel0.72327148
116MP0002114_abnormal_axial_skeleton0.71884878
117MP0003385_abnormal_body_wall0.70599804
118MP0001340_abnormal_eyelid_morphology0.70206201
119MP0004811_abnormal_neuron_physiology0.69907520
120MP0002116_abnormal_craniofacial_bone0.69720631
121MP0009278_abnormal_bone_marrow0.69668556
122MP0002233_abnormal_nose_morphology0.68960328
123MP0005367_renal/urinary_system_phenotyp0.68629982
124MP0000516_abnormal_urinary_system0.68629982
125MP0002081_perinatal_lethality0.68257417
126MP0005257_abnormal_intraocular_pressure0.66390286
127MP0005410_abnormal_fertilization0.66027421
128MP0001286_abnormal_eye_development0.65983329
129MP0002396_abnormal_hematopoietic_system0.64337921
130MP0002019_abnormal_tumor_incidence0.63263470
131MP0005023_abnormal_wound_healing0.61477941
132MP0002102_abnormal_ear_morphology0.61301661
133MP0003091_abnormal_cell_migration0.60396180

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64555974
2Chromsome breakage (HP:0040012)3.47845821
3Ependymoma (HP:0002888)3.33171720
4Abnormality of the labia minora (HP:0012880)3.20664442
5Ankle contracture (HP:0006466)3.09822300
6Pelvic girdle muscle weakness (HP:0003749)3.08959463
7Amyotrophic lateral sclerosis (HP:0007354)2.96429472
8Shoulder girdle muscle weakness (HP:0003547)2.96224248
9Abnormality of the astrocytes (HP:0100707)2.95443408
10Astrocytoma (HP:0009592)2.95443408
11Impulsivity (HP:0100710)2.92250929
12Cortical dysplasia (HP:0002539)2.89495004
13Nephroblastoma (Wilms tumor) (HP:0002667)2.78521560
14Birth length less than 3rd percentile (HP:0003561)2.75000938
15Colon cancer (HP:0003003)2.73835892
16Abnormality of the lower motor neuron (HP:0002366)2.72011313
17Facial hemangioma (HP:0000329)2.69718296
18Abnormality of the musculature of the pelvis (HP:0001469)2.68715116
19Abnormality of the hip-girdle musculature (HP:0001445)2.68715116
20Embryonal renal neoplasm (HP:0011794)2.65146638
21Selective tooth agenesis (HP:0001592)2.61658214
22Degeneration of anterior horn cells (HP:0002398)2.59326899
23Abnormality of the anterior horn cell (HP:0006802)2.59326899
24Atrophy/Degeneration involving motor neurons (HP:0007373)2.56992347
25Glioma (HP:0009733)2.49987043
26Abnormality of chromosome stability (HP:0003220)2.47945661
27Breast hypoplasia (HP:0003187)2.45490956
28Short 4th metacarpal (HP:0010044)2.44021100
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44021100
30Termporal pattern (HP:0011008)2.40815593
31Insidious onset (HP:0003587)2.40815593
32Large earlobe (HP:0009748)2.37437218
33Shallow orbits (HP:0000586)2.36261310
34Deviation of the thumb (HP:0009603)2.33622445
35Abnormal lung lobation (HP:0002101)2.30818851
36Proximal placement of thumb (HP:0009623)2.30764044
37Thyroid carcinoma (HP:0002890)2.25929144
38Medulloblastoma (HP:0002885)2.25589080
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.25271083
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.23459940
41Overlapping toe (HP:0001845)2.22461631
42Genu recurvatum (HP:0002816)2.21338467
43Abnormality of the distal phalanges of the toes (HP:0010182)2.19364088
44Increased nuchal translucency (HP:0010880)2.19130852
45Meckel diverticulum (HP:0002245)2.18975382
46Patellar aplasia (HP:0006443)2.18881096
47Leiomyosarcoma (HP:0100243)2.16730908
48Uterine leiomyosarcoma (HP:0002891)2.16730908
49Premature rupture of membranes (HP:0001788)2.15819985
50Hepatoblastoma (HP:0002884)2.15139000
51Protrusio acetabuli (HP:0003179)2.14290402
52Intestinal atresia (HP:0011100)2.14023211
53Transitional cell carcinoma of the bladder (HP:0006740)2.13729221
54Aplasia/Hypoplasia of the patella (HP:0006498)2.12915507
55Bladder neoplasm (HP:0009725)2.10196758
56Bladder carcinoma (HP:0002862)2.10196758
57Heterotopia (HP:0002282)2.10020749
58Abnormality of the carotid arteries (HP:0005344)2.09417233
59Glossoptosis (HP:0000162)2.08078366
60Rhabdomyosarcoma (HP:0002859)2.07776328
61Missing ribs (HP:0000921)2.06157741
62Deep philtrum (HP:0002002)2.05613057
63Abnormality of the ileum (HP:0001549)2.05146788
64Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.02287327
65Carpal bone hypoplasia (HP:0001498)2.01736626
66Biliary tract neoplasm (HP:0100574)2.01557774
67Drooling (HP:0002307)2.00455246
68Prominent nose (HP:0000448)2.00272781
69Oligodactyly (HP:0012165)2.00149266
70Enlarged penis (HP:0000040)1.98908362
71Spinal muscular atrophy (HP:0007269)1.96423408
72High anterior hairline (HP:0009890)1.93730413
73Abnormality of chromosome segregation (HP:0002916)1.90622508
74Volvulus (HP:0002580)1.90474347
75Duodenal stenosis (HP:0100867)1.90218851
76Small intestinal stenosis (HP:0012848)1.90218851
77Difficulty climbing stairs (HP:0003551)1.88701388
78Atresia of the external auditory canal (HP:0000413)1.87782325
79Shawl scrotum (HP:0000049)1.85553747
80Sandal gap (HP:0001852)1.84976608
81Renal duplication (HP:0000075)1.84706150
82Asymmetry of the thorax (HP:0001555)1.83884975
83Cutaneous finger syndactyly (HP:0010554)1.83364794
84Short humerus (HP:0005792)1.82512746
85Neoplasm of the oral cavity (HP:0100649)1.82061875
86Subacute progressive viral hepatitis (HP:0006572)1.81485618
87Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81435653
88Short 1st metacarpal (HP:0010034)1.81435653
89Facial cleft (HP:0002006)1.81120403
90Bowel diverticulosis (HP:0005222)1.80964816
91Aplasia/hypoplasia of the humerus (HP:0006507)1.80048990
92Microglossia (HP:0000171)1.79789155
93Broad thumb (HP:0011304)1.79498771
94Hyperacusis (HP:0010780)1.79156040
95Neoplasm of striated muscle (HP:0009728)1.79068710
96Abnormality of the preputium (HP:0100587)1.78885935
97Cerebral aneurysm (HP:0004944)1.77890677
98Abnormality of the duodenum (HP:0002246)1.77583248
99Urinary urgency (HP:0000012)1.77523143
100Abnormality of the 4th metacarpal (HP:0010012)1.75951766
101Impaired vibration sensation in the lower limbs (HP:0002166)1.75877767
102Sparse lateral eyebrow (HP:0005338)1.75082166
103Papillary thyroid carcinoma (HP:0002895)1.74990661
104Malignant gastrointestinal tract tumors (HP:0006749)1.74941476
105Gastrointestinal carcinoma (HP:0002672)1.74941476
106Obsessive-compulsive behavior (HP:0000722)1.74872568
107Embryonal neoplasm (HP:0002898)1.73706160
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73199870
109Excessive salivation (HP:0003781)1.71177341
110Hypopigmentation of the fundus (HP:0007894)1.69935223
111Broad phalanges of the hand (HP:0009768)1.69905448
112Cutaneous syndactyly (HP:0012725)1.69902508
113Neoplasm of the adrenal cortex (HP:0100641)1.68796740
114Oligodactyly (hands) (HP:0001180)1.67748232
115Absent radius (HP:0003974)1.67651518
116Basal cell carcinoma (HP:0002671)1.66876893
117Neoplasm of the pancreas (HP:0002894)1.66104534
118Relative macrocephaly (HP:0004482)1.65339545
119Wrist flexion contracture (HP:0001239)1.64420028
120Abnormality of the calcaneus (HP:0008364)1.64319077
121Cafe-au-lait spot (HP:0000957)1.63883153
122Sloping forehead (HP:0000340)1.63871792
123Absent eyebrow (HP:0002223)1.63753325
124Male infertility (HP:0003251)1.63538310
125Broad alveolar ridges (HP:0000187)1.63534227
126Abnormality of the motor neurons (HP:0002450)1.63427327
127Abnormal neuron morphology (HP:0012757)1.63427327
128High pitched voice (HP:0001620)1.63173504
129Hand muscle atrophy (HP:0009130)1.62176422
130Vertebral arch anomaly (HP:0008438)1.62136552
131Broad palm (HP:0001169)1.62126230
132Renovascular hypertension (HP:0100817)1.61907779
133Abnormality of the proximal phalanges of the hand (HP:0009834)1.61325264
134Ectopic kidney (HP:0000086)1.59558632
135Arteriovenous malformation (HP:0100026)1.59065390
136Breast carcinoma (HP:0003002)1.58117301
137Hypoplastic toenails (HP:0001800)1.56330050
138Pointed chin (HP:0000307)1.56085459
139Abnormality of the 1st metacarpal (HP:0010009)1.55947631
140Abnormality of the antihelix (HP:0009738)1.55138400
141Broad phalanx (HP:0006009)1.55118723
142Short nail (HP:0001799)1.54951556
143Short phalanx of the thumb (HP:0009660)1.54227139
144Aplasia involving forearm bones (HP:0009822)1.54216616
145Absent forearm bone (HP:0003953)1.54216616
146Broad finger (HP:0001500)1.54005761
147Omphalocele (HP:0001539)1.53944501
148Partial agenesis of the corpus callosum (HP:0001338)1.53424524
149Gastrointestinal atresia (HP:0002589)1.52985860
150Broad long bones (HP:0005622)1.52926232
151Bifid tongue (HP:0010297)1.52471675
152Rough bone trabeculation (HP:0100670)1.52268458
153Intestinal polyposis (HP:0200008)1.52218272
154Cerebral hypomyelination (HP:0006808)1.52179840
155Neoplasm of the thyroid gland (HP:0100031)1.52163116
156Megalocornea (HP:0000485)1.51527282
157Uterine neoplasm (HP:0010784)1.51416864
158Limb-girdle muscle weakness (HP:0003325)1.51366973
159Micropenis (HP:0000054)1.50638445
160Midline defect of the nose (HP:0004122)1.49171315
161Spastic diplegia (HP:0001264)1.48649578
162Neoplasm of the colon (HP:0100273)1.48622843
163Tubulointerstitial nephritis (HP:0001970)1.48197368
164Skull defect (HP:0001362)1.48051465
165Intestinal polyp (HP:0005266)1.47593382
166Truncal obesity (HP:0001956)1.47390758
167Curly hair (HP:0002212)1.45347664
168Gastroesophageal reflux (HP:0002020)1.44938352
169Malignant neoplasm of the central nervous system (HP:0100836)1.44086315
170Esophageal atresia (HP:0002032)1.44019823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.63961517
2CDC73.43551854
3NEK23.11100440
4BUB12.95385252
5LATS22.88140406
6BCR2.61853413
7CDK122.55413551
8LATS12.54700858
9TSSK62.48501382
10NEK12.48420415
11CASK2.36798593
12TAF12.34200918
13PNCK2.21631055
14TTK2.16080423
15EEF2K2.12138789
16PDK41.89281310
17PDK31.89281310
18ALK1.82068099
19PLK31.80224520
20SCYL21.76886223
21PASK1.73582899
22TRIM281.73438044
23STK31.66282761
24ERBB31.65947392
25PLK11.65636466
26EPHA21.56417982
27BRSK21.55415551
28ACVR1B1.48645562
29CAMK1G1.47550871
30KSR11.46281716
31PKN21.43194467
32PRKD31.41420401
33BMPR1B1.41101869
34STK38L1.39483173
35TRIB31.37752284
36MAP3K91.37570575
37DYRK31.35726060
38PBK1.35631603
39AKT31.34204291
40CHEK21.34062680
41CHEK11.26568357
42BRSK11.25343737
43WNK31.21962829
44MAP2K71.21206302
45SRPK11.21146215
46MTOR1.19175317
47EIF2AK11.18124102
48AURKB1.16500503
49ATR1.13024244
50MAP3K81.12851110
51CDK41.12509656
52PDGFRA1.11881661
53ZAK1.11605863
54CAMK1D1.10913048
55MKNK11.09877713
56PLK41.09020095
57MAP3K101.07833693
58KSR21.05695031
59CDK71.05036006
60TYRO31.04336221
61RPS6KB21.04332426
62PLK21.01658561
63PAK60.98235163
64CSNK1A1L0.97910359
65DDR20.97240454
66MKNK20.97170427
67PDK20.96369235
68CDK20.94022661
69STK380.93562564
70FGFR20.90936978
71MELK0.88959709
72AURKA0.85627706
73PAK40.84587210
74CDK60.84129278
75ICK0.83643635
76ATM0.82090297
77MAPK130.80370404
78VRK10.77649461
79RPS6KA40.74766064
80MET0.74576212
81CCNB10.74235767
82PAK20.73975975
83CSNK1E0.73969052
84CDK10.72975183
85FGFR10.69425397
86BRD40.67435000
87SMG10.66711181
88CDK30.66680043
89EIF2AK20.64233413
90UHMK10.63169246
91CDK180.62177432
92YES10.59034048
93NEK90.57672125
94RPS6KB10.57285387
95TGFBR10.54178247
96MAP4K20.54078203
97TESK10.52440591
98NTRK20.52288151
99PRKCI0.51598579
100TESK20.51203103
101RAF10.50630598
102PAK10.50549262
103CAMKK10.49624177
104MAP3K40.48882694
105NUAK10.46956770
106CDK80.46952518
107EPHA40.46288037
108CSNK1D0.46239520
109CDK11A0.46103828
110NEK60.45714801
111MAPK100.45099652
112MAPKAPK50.44583019
113PRKDC0.44270728
114CSNK1G20.44039785
115ERBB40.42969101
116NTRK10.41905512
117EIF2AK30.41857875
118MINK10.41096988
119FER0.40765832
120BRAF0.40160814
121MAP3K20.39492164
122SIK30.39120496
123PDGFRB0.37791916
124MARK10.37136260
125RET0.36605870
126CSNK1G30.36486421
127STK100.36464839
128MAPK140.36360309
129CDK140.36252591
130PTK20.36154162
131GSK3B0.35864425
132CSNK2A20.35749208
133PTK60.34295724
134STK110.34222352
135CSNK1G10.33242717
136CDK150.32870089
137MARK30.32318098

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030133.61974342
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55226405
3Cell cycle_Homo sapiens_hsa041102.97216514
4Vitamin B6 metabolism_Homo sapiens_hsa007502.91289861
5DNA replication_Homo sapiens_hsa030302.57804228
6Spliceosome_Homo sapiens_hsa030402.47680056
7Mismatch repair_Homo sapiens_hsa034302.42529653
8Oocyte meiosis_Homo sapiens_hsa041142.30125902
9mRNA surveillance pathway_Homo sapiens_hsa030152.24283678
10RNA polymerase_Homo sapiens_hsa030202.10612696
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.08866602
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05954111
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.96279651
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87643302
15One carbon pool by folate_Homo sapiens_hsa006701.83457009
16Steroid biosynthesis_Homo sapiens_hsa001001.78162316
17Nucleotide excision repair_Homo sapiens_hsa034201.75858172
18mTOR signaling pathway_Homo sapiens_hsa041501.71846199
19p53 signaling pathway_Homo sapiens_hsa041151.65719889
20Base excision repair_Homo sapiens_hsa034101.54946369
21Hippo signaling pathway_Homo sapiens_hsa043901.44472068
22Basal transcription factors_Homo sapiens_hsa030221.43551772
23Homologous recombination_Homo sapiens_hsa034401.34376570
24RNA degradation_Homo sapiens_hsa030181.31794930
25MicroRNAs in cancer_Homo sapiens_hsa052061.29457715
26Lysine degradation_Homo sapiens_hsa003101.27551267
27Fanconi anemia pathway_Homo sapiens_hsa034601.25584058
28Viral carcinogenesis_Homo sapiens_hsa052031.22917948
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20073744
30Propanoate metabolism_Homo sapiens_hsa006401.17820903
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17023649
32Colorectal cancer_Homo sapiens_hsa052101.11394239
33Endometrial cancer_Homo sapiens_hsa052131.09410603
34Nicotine addiction_Homo sapiens_hsa050331.09139947
35Hedgehog signaling pathway_Homo sapiens_hsa043401.08591225
36Pyrimidine metabolism_Homo sapiens_hsa002401.08439598
37Epstein-Barr virus infection_Homo sapiens_hsa051691.04676310
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04454621
39Axon guidance_Homo sapiens_hsa043601.03522678
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.02056743
41Proteasome_Homo sapiens_hsa030501.00300945
42Chronic myeloid leukemia_Homo sapiens_hsa052200.97603965
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96158857
44Adherens junction_Homo sapiens_hsa045200.95897496
45Systemic lupus erythematosus_Homo sapiens_hsa053220.95371518
46Glioma_Homo sapiens_hsa052140.94912134
47Basal cell carcinoma_Homo sapiens_hsa052170.94859579
48Alcoholism_Homo sapiens_hsa050340.93010810
49Fatty acid biosynthesis_Homo sapiens_hsa000610.92984114
50TGF-beta signaling pathway_Homo sapiens_hsa043500.92287126
51Estrogen signaling pathway_Homo sapiens_hsa049150.92193404
52Thyroid cancer_Homo sapiens_hsa052160.91688662
53Dorso-ventral axis formation_Homo sapiens_hsa043200.91242238
54Protein export_Homo sapiens_hsa030600.90743642
55Selenocompound metabolism_Homo sapiens_hsa004500.90063787
56HTLV-I infection_Homo sapiens_hsa051660.89722396
57Small cell lung cancer_Homo sapiens_hsa052220.88666518
58Biosynthesis of amino acids_Homo sapiens_hsa012300.88376480
59Non-small cell lung cancer_Homo sapiens_hsa052230.84293407
60Renal cell carcinoma_Homo sapiens_hsa052110.82797600
61Proteoglycans in cancer_Homo sapiens_hsa052050.80984615
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80833955
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80770600
64Tight junction_Homo sapiens_hsa045300.80445318
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79630012
66Pentose phosphate pathway_Homo sapiens_hsa000300.79466447
67Pyruvate metabolism_Homo sapiens_hsa006200.79461233
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.79181639
69Wnt signaling pathway_Homo sapiens_hsa043100.77416644
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76459697
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75313405
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73996027
73Prostate cancer_Homo sapiens_hsa052150.73793237
74Purine metabolism_Homo sapiens_hsa002300.73238247
75Bladder cancer_Homo sapiens_hsa052190.70835028
76Long-term potentiation_Homo sapiens_hsa047200.66478845
77AMPK signaling pathway_Homo sapiens_hsa041520.65079296
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64810696
79Glutamatergic synapse_Homo sapiens_hsa047240.62433800
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.62223231
81Non-homologous end-joining_Homo sapiens_hsa034500.61832441
82FoxO signaling pathway_Homo sapiens_hsa040680.60438270
83Glucagon signaling pathway_Homo sapiens_hsa049220.60046467
84Long-term depression_Homo sapiens_hsa047300.59438286
85Taste transduction_Homo sapiens_hsa047420.58509071
86ErbB signaling pathway_Homo sapiens_hsa040120.57397417
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57374142
88Thyroid hormone synthesis_Homo sapiens_hsa049180.57019284
89Antigen processing and presentation_Homo sapiens_hsa046120.56493551
90Focal adhesion_Homo sapiens_hsa045100.56133976
91Fatty acid metabolism_Homo sapiens_hsa012120.55513773
92Regulation of autophagy_Homo sapiens_hsa041400.55180069
93Amphetamine addiction_Homo sapiens_hsa050310.54516488
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54473222
95HIF-1 signaling pathway_Homo sapiens_hsa040660.53902818
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52340054
97Gap junction_Homo sapiens_hsa045400.51542360
98VEGF signaling pathway_Homo sapiens_hsa043700.51450153
99Melanoma_Homo sapiens_hsa052180.51007994
100Insulin signaling pathway_Homo sapiens_hsa049100.50688317
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50369753
102Pathways in cancer_Homo sapiens_hsa052000.50049664
103Inositol phosphate metabolism_Homo sapiens_hsa005620.49591479
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47586332
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47303201
106N-Glycan biosynthesis_Homo sapiens_hsa005100.46945443
107Pancreatic cancer_Homo sapiens_hsa052120.46872172
108Type II diabetes mellitus_Homo sapiens_hsa049300.45873233
109Synaptic vesicle cycle_Homo sapiens_hsa047210.45069307
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45024419
111Melanogenesis_Homo sapiens_hsa049160.43622910
112GABAergic synapse_Homo sapiens_hsa047270.43099264
113Cocaine addiction_Homo sapiens_hsa050300.41590184
114Choline metabolism in cancer_Homo sapiens_hsa052310.40642729
115Prolactin signaling pathway_Homo sapiens_hsa049170.39121235
116Nitrogen metabolism_Homo sapiens_hsa009100.38584775
117Hepatitis B_Homo sapiens_hsa051610.38532816
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38467326
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.37840965
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37798498
121Endocytosis_Homo sapiens_hsa041440.37672924
122Circadian rhythm_Homo sapiens_hsa047100.34492030
123Dopaminergic synapse_Homo sapiens_hsa047280.33421120
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32552431
125ECM-receptor interaction_Homo sapiens_hsa045120.31983337
126Notch signaling pathway_Homo sapiens_hsa043300.31165915

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