CANT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10873338
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10873338
3antigen processing and presentation of endogenous antigen (GO:0019883)4.47737893
4positive regulation of Cdc42 GTPase activity (GO:0043089)4.20009620
5Golgi transport vesicle coating (GO:0048200)3.75476171
6COPI coating of Golgi vesicle (GO:0048205)3.75476171
7positive regulation of histone deacetylation (GO:0031065)3.70140696
8intestinal absorption (GO:0050892)3.69755365
9desmosome organization (GO:0002934)3.67816728
10regulation of cholesterol homeostasis (GO:2000188)3.66137250
11low-density lipoprotein particle clearance (GO:0034383)3.60148012
12hemidesmosome assembly (GO:0031581)3.37631595
13activation of Rac GTPase activity (GO:0032863)3.33469887
14branching involved in mammary gland duct morphogenesis (GO:0060444)3.31205199
15pentose-phosphate shunt (GO:0006098)3.28192498
16regulation of cholesterol storage (GO:0010885)3.17779693
17valine metabolic process (GO:0006573)3.14732100
18apoptotic cell clearance (GO:0043277)3.09662872
19intestinal cholesterol absorption (GO:0030299)3.08991104
20mannose metabolic process (GO:0006013)3.04381309
21epithelial cell-cell adhesion (GO:0090136)3.03605019
22negative regulation of erythrocyte differentiation (GO:0045647)3.02184306
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.01697187
24sulfur amino acid catabolic process (GO:0000098)3.00043934
25regulation of fatty acid beta-oxidation (GO:0031998)2.99572709
26skin morphogenesis (GO:0043589)2.97852482
27NADPH regeneration (GO:0006740)2.97433648
28regulation of gamma-delta T cell differentiation (GO:0045586)2.96356612
29cell-substrate junction assembly (GO:0007044)2.94980088
30amyloid precursor protein catabolic process (GO:0042987)2.92972159
31protein localization to endosome (GO:0036010)2.92167820
32positive regulation of nuclease activity (GO:0032075)2.92124213
33barbed-end actin filament capping (GO:0051016)2.87706286
34antigen processing and presentation via MHC class Ib (GO:0002475)2.86483205
35proline biosynthetic process (GO:0006561)2.86330410
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85650883
37adherens junction assembly (GO:0034333)2.84935206
38tricarboxylic acid metabolic process (GO:0072350)2.82814213
39growth hormone receptor signaling pathway (GO:0060396)2.81647688
40endothelial cell chemotaxis (GO:0035767)2.80797345
41maternal placenta development (GO:0001893)2.79373089
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79214001
43positive regulation of gamma-delta T cell activation (GO:0046645)2.78249096
44cell-substrate adherens junction assembly (GO:0007045)2.75658028
45focal adhesion assembly (GO:0048041)2.75658028
46positive regulation of keratinocyte differentiation (GO:0045618)2.74857135
47semaphorin-plexin signaling pathway (GO:0071526)2.74091608
48alpha-linolenic acid metabolic process (GO:0036109)2.71847763
49response to laminar fluid shear stress (GO:0034616)2.71179604
50cytoskeletal anchoring at plasma membrane (GO:0007016)2.71103448
514-hydroxyproline metabolic process (GO:0019471)2.70664992
52protein retention in ER lumen (GO:0006621)2.70387164
53negative regulation of viral release from host cell (GO:1902187)2.70097756
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69986647
55regulation of early endosome to late endosome transport (GO:2000641)2.68501773
56negative regulation of fatty acid transport (GO:2000192)2.68279273
57regulation of T cell tolerance induction (GO:0002664)2.66382431
58embryonic process involved in female pregnancy (GO:0060136)2.66281741
59regulation of glucose import in response to insulin stimulus (GO:2001273)2.66048469
60maintenance of gastrointestinal epithelium (GO:0030277)2.65712440
61positive regulation of protein deacetylation (GO:0090312)2.65296486
62membrane protein ectodomain proteolysis (GO:0006509)2.65257201
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65015036
64epithelial structure maintenance (GO:0010669)2.64955329
65UDP-N-acetylglucosamine metabolic process (GO:0006047)2.64245150
66regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.62050803
67positive regulation of triglyceride metabolic process (GO:0090208)2.62026920
68GDP-mannose metabolic process (GO:0019673)2.61130262
69regulation of water loss via skin (GO:0033561)2.60725833
70positive regulation of fatty acid beta-oxidation (GO:0032000)2.59826298
71positive regulation of triglyceride biosynthetic process (GO:0010867)2.59156119
72positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59022239
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58639422
74response to peptidoglycan (GO:0032494)2.58565529
75positive regulation of pseudopodium assembly (GO:0031274)2.58516264
76regulation of nuclease activity (GO:0032069)2.58132435
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.56977935
78regulation of gamma-delta T cell activation (GO:0046643)2.55847483
79pinocytosis (GO:0006907)2.55148480
80regulation of viral release from host cell (GO:1902186)2.54768468
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54590793
82hypotonic response (GO:0006971)2.54579449
83receptor catabolic process (GO:0032801)2.52942554
84positive thymic T cell selection (GO:0045059)2.52478879
85apoptotic process involved in morphogenesis (GO:0060561)2.51962668
86hormone catabolic process (GO:0042447)2.51039601
87endoplasmic reticulum unfolded protein response (GO:0030968)2.50579446
88positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50510689
89JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.48510065
90iron ion import (GO:0097286)2.47569138
91peptidyl-tyrosine autophosphorylation (GO:0038083)2.46818761
92epithelial cell differentiation involved in prostate gland development (GO:0060742)2.46531085
93negative regulation of cholesterol transport (GO:0032375)2.45171181
94negative regulation of sterol transport (GO:0032372)2.45171181
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44642288
96modulation by symbiont of host immune response (GO:0052553)2.44308351
97positive regulation by symbiont of host defense response (GO:0052509)2.44308351
98modulation by symbiont of host defense response (GO:0052031)2.44308351
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44308351
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44308351
101positive regulation by organism of defense response of other organism involved in symbiotic interact2.44308351
102flavonoid metabolic process (GO:0009812)2.44256163
103regulation of vitamin metabolic process (GO:0030656)2.43478321
104glucose 6-phosphate metabolic process (GO:0051156)2.42271398
105positive regulation of receptor recycling (GO:0001921)2.41453602
106stress fiber assembly (GO:0043149)2.40391333
107protein autoprocessing (GO:0016540)2.40159661
108O-glycan processing (GO:0016266)2.40158678
109glycosphingolipid catabolic process (GO:0046479)2.40140448
110modulation by symbiont of host cellular process (GO:0044068)2.39591440
111COPII vesicle coating (GO:0048208)2.38150247
112L-serine transport (GO:0015825)2.37165855
113cellular response to unfolded protein (GO:0034620)2.37008130
114negative regulation of lipid transport (GO:0032369)2.36319605
115NIK/NF-kappaB signaling (GO:0038061)2.34993104
116mammary gland epithelial cell differentiation (GO:0060644)2.34418614
117white fat cell differentiation (GO:0050872)2.34024217
118cellular response to growth hormone stimulus (GO:0071378)2.33334980
119amyloid precursor protein metabolic process (GO:0042982)2.32729701
120negative regulation of cell size (GO:0045792)2.31628792
121regulation of integrin activation (GO:0033623)2.31290843
122lipoprotein transport (GO:0042953)2.31033235
123regulation of fatty acid oxidation (GO:0046320)2.30664002
124cell-cell junction maintenance (GO:0045217)2.30565777
125modulation by virus of host morphology or physiology (GO:0019048)2.30300536
126sodium ion export (GO:0071436)2.29783135
127regulation of defense response to virus by virus (GO:0050690)2.29751774
128serine transport (GO:0032329)2.28890956
129oxaloacetate metabolic process (GO:0006107)2.28359297
130positive regulation of epidermal cell differentiation (GO:0045606)2.28169552
131sulfation (GO:0051923)2.28082840
132protein-lipid complex assembly (GO:0065005)2.27814981
133vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.27574661
134dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27511952
135cellular response to virus (GO:0098586)2.27117462
136positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26742110
137angiotensin maturation (GO:0002003)2.26160226
138basement membrane organization (GO:0071711)2.25891883
139regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25883262
140trophectodermal cell differentiation (GO:0001829)2.25521399
141NADH metabolic process (GO:0006734)2.25422038
142positive regulation of tolerance induction (GO:0002645)2.25417759
143ER-nucleus signaling pathway (GO:0006984)2.25005597
144diacylglycerol metabolic process (GO:0046339)2.24843340
145response to food (GO:0032094)2.23225245
146actin filament bundle assembly (GO:0051017)2.23111901
147actin filament bundle organization (GO:0061572)2.23111901
148negative regulation of protein localization to plasma membrane (GO:1903077)2.22791553
149triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.22558334
150glucose catabolic process (GO:0006007)2.22410945
151positive regulation of p38MAPK cascade (GO:1900745)2.21692764
152sexual reproduction (GO:0019953)2.21682514
153regulation of extracellular matrix disassembly (GO:0010715)2.21449601
154positive regulation of fatty acid oxidation (GO:0046321)2.20831381
155lipopolysaccharide-mediated signaling pathway (GO:0031663)2.20794983
156fatty acid beta-oxidation (GO:0006635)2.20766923
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.20721437
158lysine metabolic process (GO:0006553)2.20217759
159lysine catabolic process (GO:0006554)2.20217759
160vesicle coating (GO:0006901)2.19214103
161adhesion of symbiont to host (GO:0044406)2.18768950
162positive regulation of fatty acid biosynthetic process (GO:0045723)2.18564830
163regulation of interleukin-12 biosynthetic process (GO:0045075)2.18454453
164regulation of triglyceride catabolic process (GO:0010896)2.18452660
165positive regulation of lipid storage (GO:0010884)2.18162842
166cellular response to topologically incorrect protein (GO:0035967)2.17721123
167negative regulation of innate immune response (GO:0045824)2.16898805
168defense response to fungus (GO:0050832)2.15893656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.41874594
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.17103962
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72030368
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.61442632
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60604295
6MYC_22102868_ChIP-Seq_BL_Human2.50536116
7VDR_21846776_ChIP-Seq_THP-1_Human2.41449505
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.38441120
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.36545798
10LXR_22292898_ChIP-Seq_THP-1_Human2.23113722
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.11958721
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.10741133
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06733193
14TCF7_22412390_ChIP-Seq_EML_Mouse2.03418321
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03131872
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01845936
17KDM2B_26808549_Chip-Seq_DND41_Human2.00338160
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97583787
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95861354
20CLOCK_20551151_ChIP-Seq_293T_Human1.89529240
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88236453
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86235626
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83765738
24RACK7_27058665_Chip-Seq_MCF-7_Human1.83343122
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76695838
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76309241
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76195734
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74851113
29MAF_26560356_Chip-Seq_TH1_Human1.72354541
30VDR_24763502_ChIP-Seq_THP-1_Human1.71556349
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71500249
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.66570368
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.64045006
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62507569
35UTX_26944678_Chip-Seq_JUKART_Human1.61861724
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60266214
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.58769350
38SCL_19346495_ChIP-Seq_HPC-7_Human1.58655867
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58557893
40GATA1_22025678_ChIP-Seq_K562_Human1.55554900
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.54795004
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53370442
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53219423
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51206765
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51095021
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48503577
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48090103
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46800975
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.44496215
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42999599
51SPI1_23127762_ChIP-Seq_K562_Human1.42625413
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42583447
53* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41435749
54ZNF263_19887448_ChIP-Seq_K562_Human1.40057656
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.38982343
56* ATF3_27146783_Chip-Seq_COLON_Human1.38454647
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37944804
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37510402
59GATA1_19941826_ChIP-Seq_K562_Human1.36178210
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35508484
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31435259
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30720247
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.30559251
64GATA6_25053715_ChIP-Seq_YYC3_Human1.30327981
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30156722
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29366146
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28571426
68* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28237629
69KDM2B_26808549_Chip-Seq_K562_Human1.27499784
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27332560
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25579268
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25082789
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23659622
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.21788187
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21575154
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.21282239
77* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20941097
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.20372746
79GATA2_19941826_ChIP-Seq_K562_Human1.19797900
80* CREB1_26743006_Chip-Seq_LNCaP_Human1.19724002
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19492106
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19147461
83NCOR1_26117541_ChIP-Seq_K562_Human1.18832142
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17880404
85* P68_20966046_ChIP-Seq_HELA_Human1.17735889
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17482236
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17467291
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16578796
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15157932
90AR_21909140_ChIP-Seq_LNCAP_Human1.15148501
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14626888
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.13719606
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13273608
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.13207296
95TP53_22127205_ChIP-Seq_IMR90_Human1.12305307
96* GATA4_25053715_ChIP-Seq_YYC3_Human1.11944372
97* SMC4_20622854_ChIP-Seq_HELA_Human1.11834882
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09742120
99MYB_26560356_Chip-Seq_TH2_Human1.09661156
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09087447
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08861837
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.08445500
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.08431945
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.07419312
105* BCOR_27268052_Chip-Seq_Bcells_Human1.07064272
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06803095
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06790507
108* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06742014
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06654444
110BCL6_27268052_Chip-Seq_Bcells_Human1.06541520
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06157524
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06157524
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06014762
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05907348
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05455021
116PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05446660
117MAF_26560356_Chip-Seq_TH2_Human1.05244535
118CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04486875
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03579267
120RUNX_20019798_ChIP-Seq_JUKART_Human1.02718003
121MYB_26560356_Chip-Seq_TH1_Human1.01258167
122* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00795581
123CHD1_26751641_Chip-Seq_LNCaP_Human1.00554202
124* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00276291
125STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00125973
126* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00072239
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98348098
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96115456
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.96073479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.50733648
2MP0003705_abnormal_hypodermis_morpholog3.40351580
3MP0003300_gastrointestinal_ulcer3.20451647
4MP0005451_abnormal_body_composition3.17685273
5MP0010234_abnormal_vibrissa_follicle2.88004533
6MP0009840_abnormal_foam_cell2.82919619
7MP0004858_abnormal_nervous_system2.63297229
8MP0003191_abnormal_cellular_cholesterol2.51421279
9MP0003252_abnormal_bile_duct2.34336079
10MP0005058_abnormal_lysosome_morphology2.30845928
11MP0002796_impaired_skin_barrier2.28376683
12MP0001873_stomach_inflammation2.22118497
13MP0008438_abnormal_cutaneous_collagen2.19922260
14MP0003303_peritoneal_inflammation2.09889010
15MP0001666_abnormal_nutrient_absorption2.05693856
16MP0002139_abnormal_hepatobiliary_system1.94413436
17MP0003866_abnormal_defecation1.92386418
18MP0010352_gastrointestinal_tract_polyps1.90381696
19MP0005409_darkened_coat_color1.88024542
20MP0010155_abnormal_intestine_physiology1.86499100
21MP0008260_abnormal_autophagy1.83461832
22MP0000685_abnormal_immune_system1.83453298
23MP0006054_spinal_hemorrhage1.83380405
24MP0005365_abnormal_bile_salt1.76939797
25MP0010329_abnormal_lipoprotein_level1.76579428
26MP0008961_abnormal_basal_metabolism1.74900685
27MP0002138_abnormal_hepatobiliary_system1.71263075
28MP0008875_abnormal_xenobiotic_pharmacok1.70022776
29MP0005167_abnormal_blood-brain_barrier1.66919508
30MP0005085_abnormal_gallbladder_physiolo1.64457345
31MP0003283_abnormal_digestive_organ1.58564735
32MP0004264_abnormal_extraembryonic_tissu1.57656687
33MP0000678_abnormal_parathyroid_gland1.54761057
34MP0001849_ear_inflammation1.54705139
35MP0005501_abnormal_skin_physiology1.53270583
36MP0001348_abnormal_lacrimal_gland1.53129806
37MP0003566_abnormal_cell_adhesion1.46276499
38MP0000609_abnormal_liver_physiology1.45652033
39MP0004185_abnormal_adipocyte_glucose1.45325092
40MP0005464_abnormal_platelet_physiology1.44535126
41MP0004233_abnormal_muscle_weight1.44137224
42MP0009643_abnormal_urine_homeostasis1.41343480
43MP0003436_decreased_susceptibility_to1.40248404
44MP0004130_abnormal_muscle_cell1.39887091
45MP0005023_abnormal_wound_healing1.38608818
46MP0009278_abnormal_bone_marrow1.38487922
47MP0002877_abnormal_melanocyte_morpholog1.37828864
48MP0004947_skin_inflammation1.36663412
49MP0005666_abnormal_adipose_tissue1.33148911
50MP0003724_increased_susceptibility_to1.32831747
51MP0003172_abnormal_lysosome_physiology1.31235963
52MP0002098_abnormal_vibrissa_morphology1.30577816
53MP0001663_abnormal_digestive_system1.30375909
54MP0005670_abnormal_white_adipose1.28950297
55MP0001790_abnormal_immune_system1.25486059
56MP0005387_immune_system_phenotype1.25486059
57MP0000465_gastrointestinal_hemorrhage1.25158924
58MP0005257_abnormal_intraocular_pressure1.24882562
59MP0000477_abnormal_intestine_morphology1.24545479
60MP0004782_abnormal_surfactant_physiolog1.24232173
61MP0001216_abnormal_epidermal_layer1.23725883
62MP0001958_emphysema1.20534267
63MP0000490_abnormal_crypts_of1.18449195
64MP0002118_abnormal_lipid_homeostasis1.17456913
65MP0003806_abnormal_nucleotide_metabolis1.16161051
66MP0002896_abnormal_bone_mineralization1.15654259
67MP0005083_abnormal_biliary_tract1.15251225
68MP0005076_abnormal_cell_differentiation1.15052439
69MP0005375_adipose_tissue_phenotype1.14549031
70MP0003075_altered_response_to1.13555782
71MP0005381_digestive/alimentary_phenotyp1.09286263
72MP0000627_abnormal_mammary_gland1.08271595
73MP0001835_abnormal_antigen_presentation1.07745564
74MP0000013_abnormal_adipose_tissue1.06958951
75MP0005025_abnormal_response_to1.06360621
76MP0000604_amyloidosis1.06140281
77MP0001881_abnormal_mammary_gland1.06133850
78MP0002909_abnormal_adrenal_gland1.03819070
79MP0003183_abnormal_peptide_metabolism1.03403696
80MP0002254_reproductive_system_inflammat1.02663467
81MP0001845_abnormal_inflammatory_respons1.02128516
82MP0002166_altered_tumor_susceptibility1.01748610
83MP0002006_tumorigenesis1.00251839
84MP0001800_abnormal_humoral_immune0.99733988
85MP0004510_myositis0.97743476
86MP0003045_fibrosis0.97044595
87MP0009333_abnormal_splenocyte_physiolog0.96958485
88MP0000462_abnormal_digestive_system0.96764128
89MP0002452_abnormal_antigen_presenting0.96145382
90MP0003091_abnormal_cell_migration0.94917406
91MP0001533_abnormal_skeleton_physiology0.94837835
92MP0001765_abnormal_ion_homeostasis0.94454581
93MP0005275_abnormal_skin_tensile0.94017738
94MP0000003_abnormal_adipose_tissue0.92584094
95MP0000537_abnormal_urethra_morphology0.92211066
96MP0003448_altered_tumor_morphology0.91187963
97MP0002060_abnormal_skin_morphology0.90461067
98MP0005310_abnormal_salivary_gland0.90378736
99MP0002089_abnormal_postnatal_growth/wei0.89776242
100MP0004043_abnormal_pH_regulation0.89664806
101MP0006082_CNS_inflammation0.89443325
102MP0003453_abnormal_keratinocyte_physiol0.89443289
103MP0002009_preneoplasia0.89443211
104MP0005166_decreased_susceptibility_to0.89413555
105MP0009931_abnormal_skin_appearance0.88665545
106MP0003329_amyloid_beta_deposits0.88361544
107MP0002136_abnormal_kidney_physiology0.88280287
108MP0000598_abnormal_liver_morphology0.88116107
109MP0008469_abnormal_protein_level0.87525156
110MP0002998_abnormal_bone_remodeling0.87417924
111MP0000767_abnormal_smooth_muscle0.87151347
112MP0001664_abnormal_digestion0.86573030
113MP0002405_respiratory_system_inflammati0.86315219
114MP0004272_abnormal_basement_membrane0.86135434
115MP0003868_abnormal_feces_composition0.85897292
116MP0005584_abnormal_enzyme/coenzyme_acti0.85771144
117MP0005332_abnormal_amino_acid0.85217064
118MP0002419_abnormal_innate_immunity0.85024973
119MP0000858_altered_metastatic_potential0.84894227
120MP0005000_abnormal_immune_tolerance0.84758237
121MP0001819_abnormal_immune_cell0.84274572
122MP0002420_abnormal_adaptive_immunity0.83555829
123MP0002723_abnormal_immune_serum0.82744552
124MP0000467_abnormal_esophagus_morphology0.81505983
125MP0003279_aneurysm0.81171646
126MP0000733_abnormal_muscle_development0.79162819
127MP0000377_abnormal_hair_follicle0.77326225
128MP0009785_altered_susceptibility_to0.76935185
129MP0005248_abnormal_Harderian_gland0.76343983
130MP0005621_abnormal_cell_physiology0.75474520
131MP0005623_abnormal_meninges_morphology0.74924513
132MP0002148_abnormal_hypersensitivity_rea0.73493523
133MP0002396_abnormal_hematopoietic_system0.72393926
134MP0003795_abnormal_bone_structure0.70706511
135MP0003763_abnormal_thymus_physiology0.69866268
136MP0005390_skeleton_phenotype0.69029997
137MP0009384_cardiac_valve_regurgitation0.68995273
138MP0000681_abnormal_thyroid_gland0.68330622
139MP0003828_pulmonary_edema0.67970039

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)3.60327586
2Cerebral aneurysm (HP:0004944)3.59488730
3Mucopolysacchariduria (HP:0008155)3.52058971
4Urinary glycosaminoglycan excretion (HP:0003541)3.52058971
5Abnormality of the nasal mucosa (HP:0000433)3.46560878
6Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22695944
7Abnormality of polysaccharide metabolism (HP:0011012)3.22695944
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22695944
9Nasal polyposis (HP:0100582)3.18850460
10Hyperacusis (HP:0010780)3.17423349
11Pustule (HP:0200039)3.14380351
12Broad face (HP:0000283)3.06488291
13Vertebral compression fractures (HP:0002953)2.89241612
14Aortic aneurysm (HP:0004942)2.88144021
15Vacuolated lymphocytes (HP:0001922)2.87395347
16Protrusio acetabuli (HP:0003179)2.69310940
17Ileus (HP:0002595)2.66746456
18Cervical subluxation (HP:0003308)2.65902638
19Short nail (HP:0001799)2.65219370
20Increased connective tissue (HP:0009025)2.65022162
21Gastrointestinal inflammation (HP:0004386)2.64066624
22Polycythemia (HP:0001901)2.61113145
23Autoimmune thrombocytopenia (HP:0001973)2.56939060
24Distal lower limb amyotrophy (HP:0008944)2.55384682
25Chronic otitis media (HP:0000389)2.54569520
26Sparse lateral eyebrow (HP:0005338)2.52538768
27* Flat acetabular roof (HP:0003180)2.52505593
28Inflammation of the large intestine (HP:0002037)2.50471373
29Right ventricular cardiomyopathy (HP:0011663)2.49914969
30Aneurysm (HP:0002617)2.47683808
31Achilles tendon contracture (HP:0001771)2.46230227
32Colitis (HP:0002583)2.42816053
33Hyperparathyroidism (HP:0000843)2.42025121
34Hemorrhage of the eye (HP:0011885)2.40378637
35Aortic dissection (HP:0002647)2.36932138
36Polygenic inheritance (HP:0010982)2.34511244
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.32769131
38Osteolytic defects of the hand bones (HP:0009699)2.32769131
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.30848333
40Peritonitis (HP:0002586)2.28301380
41Hand muscle atrophy (HP:0009130)2.27441048
42Distal lower limb muscle weakness (HP:0009053)2.27420683
43Deep venous thrombosis (HP:0002625)2.26984945
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26918883
45Upper limb amyotrophy (HP:0009129)2.25791190
46Distal upper limb amyotrophy (HP:0007149)2.25791190
47Xanthomatosis (HP:0000991)2.25406204
48Bone pain (HP:0002653)2.25392887
49Interstitial pulmonary disease (HP:0006530)2.24616360
50Increased cerebral lipofuscin (HP:0011813)2.22018036
51Asymmetric septal hypertrophy (HP:0001670)2.21875198
52Thin bony cortex (HP:0002753)2.17178528
53Malnutrition (HP:0004395)2.16109162
54Axonal loss (HP:0003447)2.14124476
55Systemic lupus erythematosus (HP:0002725)2.13908338
56Abdominal distention (HP:0003270)2.11845783
57Late onset (HP:0003584)2.11383560
58Dilatation of the ascending aorta (HP:0005111)2.09988558
59Abnormality of macrophages (HP:0004311)2.09111295
60Mitral valve prolapse (HP:0001634)2.08037842
61Ketoacidosis (HP:0001993)2.07818867
62Asymmetry of the thorax (HP:0001555)2.06871061
63Spinal cord compression (HP:0002176)2.06801259
64Segmental peripheral demyelination/remyelination (HP:0003481)2.05983324
65Gastrointestinal dysmotility (HP:0002579)2.04703419
66Loss of speech (HP:0002371)2.04161805
67Spontaneous hematomas (HP:0007420)2.03072439
68Shallow orbits (HP:0000586)2.02121024
69Hematochezia (HP:0002573)2.00942084
70Long palpebral fissure (HP:0000637)2.00875534
71* Blue sclerae (HP:0000592)2.00276115
72Hydroxyprolinuria (HP:0003080)1.99705004
73Abnormality of proline metabolism (HP:0010907)1.99705004
74Bladder diverticulum (HP:0000015)1.99677192
75Recurrent viral infections (HP:0004429)1.97560514
76Complement deficiency (HP:0004431)1.96427906
77Abnormality of glycolipid metabolism (HP:0010969)1.96296762
78Abnormality of liposaccharide metabolism (HP:0010968)1.96296762
79Abnormality of glycosphingolipid metabolism (HP:0004343)1.96296762
80Long toe (HP:0010511)1.95975125
81Arterial tortuosity (HP:0005116)1.94375796
82Abnormal vertebral ossification (HP:0100569)1.94011701
83Cardiomegaly (HP:0001640)1.93893236
84Abnormal platelet function (HP:0011869)1.93271032
85Impaired platelet aggregation (HP:0003540)1.93271032
86Hypoglycemic coma (HP:0001325)1.92376375
87Difficulty climbing stairs (HP:0003551)1.92362079
88Elfin facies (HP:0004428)1.92071567
89Eczematoid dermatitis (HP:0000976)1.91994558
90* Broad metatarsal (HP:0001783)1.90829778
91Fatigue (HP:0012378)1.89865451
92Pili torti (HP:0003777)1.88385875
93Premature rupture of membranes (HP:0001788)1.88144025
94Insomnia (HP:0100785)1.86368818
95Mildly elevated creatine phosphokinase (HP:0008180)1.85860313
96* Abnormality of the distal phalanx of the thumb (HP:0009617)1.85628663
97Ulnar bowing (HP:0003031)1.84009575
98Fragile skin (HP:0001030)1.83965616
99Atrophic scars (HP:0001075)1.83825674
100Ankle contracture (HP:0006466)1.83575410
101Abnormality of complement system (HP:0005339)1.83391426
102Abnormality of T cell physiology (HP:0011840)1.83125910
103Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82402266
104Recurrent fungal infections (HP:0002841)1.81997927
105Ketosis (HP:0001946)1.81620126
106Esophageal varix (HP:0002040)1.81301129
107Increased IgE level (HP:0003212)1.80354553
108Cupped ribs (HP:0000887)1.80124067
109Abnormality of the gastric mucosa (HP:0004295)1.79317869
110Vascular tortuosity (HP:0004948)1.78821436
111Wormian bones (HP:0002645)1.78416648
112Mesangial abnormality (HP:0001966)1.78288450
113Gingivitis (HP:0000230)1.77832039
114Cerebral inclusion bodies (HP:0100314)1.77550693
115* Severe short stature (HP:0003510)1.77343091
116Advanced eruption of teeth (HP:0006288)1.76745933
117Abnormal cartilage morphology (HP:0002763)1.74345598
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.73604374
119Abnormality of the thoracic spine (HP:0100711)1.73027454
120Bowed forearm bones (HP:0003956)1.72932662
121Bowing of the arm (HP:0006488)1.72932662
122Overriding aorta (HP:0002623)1.71927921
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71259267
124Disproportionate tall stature (HP:0001519)1.70682451
125Ankyloglossia (HP:0010296)1.70615417
126Cellulitis (HP:0100658)1.70581144
127Myocardial infarction (HP:0001658)1.70096582
128Insidious onset (HP:0003587)1.70086317
129Termporal pattern (HP:0011008)1.70086317
130Recurrent abscess formation (HP:0002722)1.68175841
131Elevated alkaline phosphatase (HP:0003155)1.67775748
132Radial bowing (HP:0002986)1.67392574
133Trismus (HP:0000211)1.67002813
134Syringomyelia (HP:0003396)1.66986296
135Spinal cord lesions (HP:0100561)1.66986296
136Hypercortisolism (HP:0001578)1.66212803
137Intrahepatic cholestasis (HP:0001406)1.65854230
138Petechiae (HP:0000967)1.65493798
139Persistence of primary teeth (HP:0006335)1.65429605
140J-shaped sella turcica (HP:0002680)1.65387242
141Abnormality of the Achilles tendon (HP:0005109)1.65243100
142Growth hormone excess (HP:0000845)1.64677391
143Ectopia lentis (HP:0001083)1.64473767
144Micronodular cirrhosis (HP:0001413)1.64431381
145Ovoid vertebral bodies (HP:0003300)1.63806823
146Biconcave vertebral bodies (HP:0004586)1.62858243
147Spinal rigidity (HP:0003306)1.61900827
148Amyloidosis (HP:0011034)1.60877268
149Mitral regurgitation (HP:0001653)1.60041363
150Obstructive sleep apnea (HP:0002870)1.57998760
151Multiple lipomas (HP:0001012)1.57739026
152Curly hair (HP:0002212)1.57284515
153Abnormality of alkaline phosphatase activity (HP:0004379)1.56995853
154Bulbar palsy (HP:0001283)1.56798299
155Abnormality of oral frenula (HP:0000190)1.56701854
156Germ cell neoplasia (HP:0100728)1.55600228
157Alopecia of scalp (HP:0002293)1.55350014
158Pathologic fracture (HP:0002756)1.54087079
159Metaphyseal cupping (HP:0003021)1.53338445
160Tibial bowing (HP:0002982)1.52758617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.49260511
2ERN14.06844253
3EEF2K3.00737924
4PKN22.99242157
5SMG12.98320483
6MAP3K102.96924887
7IRAK32.65827806
8MAP4K12.26127904
9PRPF4B2.25379527
10TGFBR22.18609686
11PTK62.17548074
12RIPK12.12804780
13LRRK22.00205394
14KSR21.78492643
15EPHB11.75845238
16GRK61.75096904
17FGFR41.70759489
18LMTK21.68642671
19TYK21.65521278
20SIK11.54274876
21MAP2K21.53881197
22TTN1.37326300
23SCYL21.33719488
24TAOK21.29055085
25PDGFRA1.26888913
26TBK11.24600283
27STK101.24370921
28MST1R1.23756754
29TAOK11.21773943
30CAMK1D1.20530146
31RIPK41.17230746
32PRKG21.16276780
33TESK11.13615222
34JAK11.13274151
35IRAK41.12771534
36ZAP701.11435111
37DYRK1B1.09828542
38ITK1.07754356
39MAP3K91.04306769
40CDC42BPA1.03554501
41PAK41.01944941
42ICK1.01721270
43BMX1.01112918
44PTK21.00586170
45MAP3K70.97738300
46FLT30.97592871
47KDR0.97095947
48MAP3K20.95788091
49TAOK30.94816173
50MARK20.93473613
51PAK20.92831477
52JAK30.92642602
53MAP3K80.90076986
54BCKDK0.87977861
55JAK20.87875432
56ARAF0.86911009
57PRKD30.86106819
58CAMK1G0.85993816
59CSK0.85766598
60BTK0.85258883
61MAP3K10.83015046
62HIPK20.82169822
63MAP3K130.82068646
64MAP3K140.79455185
65RET0.79114818
66DDR20.78732175
67RPS6KA20.78172341
68HCK0.77818562
69CAMKK10.75654899
70IRAK20.75288347
71PRKCH0.74336119
72MTOR0.73988887
73CDK120.73507624
74PDGFRB0.73435542
75MET0.73313601
76KIT0.73089642
77MAP2K10.72407395
78BLK0.72229950
79MAPKAPK30.71941097
80TNK20.70720611
81ALK0.70554215
82TGFBR10.70214348
83MAP3K110.69439460
84CSF1R0.68752933
85TESK20.68232155
86MATK0.67855167
87SIK30.67093931
88PRKD20.65698710
89PAK30.65211863
90CDK70.64591452
91NTRK10.64121659
92LATS20.63354837
93TYRO30.61945562
94FER0.61726206
95RPS6KB20.61679350
96STK380.60739771
97NME20.59132569
98RAF10.58839560
99PRKCI0.58177008
100RPS6KC10.57091253
101RPS6KL10.57091253
102MAPK110.55914252
103DMPK0.55253802
104RPS6KA40.54560797
105EPHB20.53901780
106MAP3K60.53458271
107PRKD10.53286916
108MAP2K30.53060603
109PDPK10.52649954
110MAPK150.49944802
111MAP3K30.49806729
112PAK60.49646518
113PRKAA20.48495734
114TIE10.48459812
115PASK0.47754035
116ILK0.46178837
117CDK60.45779612
118PDK10.45571147
119PIM20.44619360
120MST40.44409056
121MAPKAPK20.43899319
122SYK0.41689629
123EPHA20.39708249
124CDK40.38144307
125BRAF0.35908086
126CHUK0.35488119
127YES10.35465406
128RPS6KA60.34988160
129EIF2AK10.34136126
130FGR0.34129562
131IRAK10.33665773

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.31298782
2Nitrogen metabolism_Homo sapiens_hsa009102.24922904
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.03869154
4Fat digestion and absorption_Homo sapiens_hsa049752.01854865
5Sulfur metabolism_Homo sapiens_hsa009201.93019587
6Caffeine metabolism_Homo sapiens_hsa002321.77476652
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.66324994
8PPAR signaling pathway_Homo sapiens_hsa033201.61735081
9Bile secretion_Homo sapiens_hsa049761.61028499
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60695006
11Other glycan degradation_Homo sapiens_hsa005111.58731057
12Fatty acid degradation_Homo sapiens_hsa000711.52556710
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52541426
14Notch signaling pathway_Homo sapiens_hsa043301.50195347
15Hepatitis C_Homo sapiens_hsa051601.47313682
16Fatty acid biosynthesis_Homo sapiens_hsa000611.46413796
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46236166
18Lysosome_Homo sapiens_hsa041421.36139000
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30041935
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29542161
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29081859
22Chronic myeloid leukemia_Homo sapiens_hsa052201.28765623
23B cell receptor signaling pathway_Homo sapiens_hsa046621.23447729
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22848939
25TNF signaling pathway_Homo sapiens_hsa046681.22592476
26Renal cell carcinoma_Homo sapiens_hsa052111.21548261
27Bladder cancer_Homo sapiens_hsa052191.20830209
28Tryptophan metabolism_Homo sapiens_hsa003801.19759517
29Insulin resistance_Homo sapiens_hsa049311.18693590
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.15659033
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.13197137
32Prostate cancer_Homo sapiens_hsa052151.12442679
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12249751
34Starch and sucrose metabolism_Homo sapiens_hsa005001.11807327
35Influenza A_Homo sapiens_hsa051641.10693680
36Prion diseases_Homo sapiens_hsa050201.10070022
37Acute myeloid leukemia_Homo sapiens_hsa052211.09552032
38Salmonella infection_Homo sapiens_hsa051321.08631749
39Mineral absorption_Homo sapiens_hsa049781.08496670
40Staphylococcus aureus infection_Homo sapiens_hsa051501.08454311
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08225144
42Vibrio cholerae infection_Homo sapiens_hsa051101.08190420
43Hepatitis B_Homo sapiens_hsa051611.06896706
44Osteoclast differentiation_Homo sapiens_hsa043801.04107271
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.00170589
46Endocytosis_Homo sapiens_hsa041440.99841246
47ABC transporters_Homo sapiens_hsa020100.99318575
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98388161
49Folate biosynthesis_Homo sapiens_hsa007900.97138054
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96802102
51Galactose metabolism_Homo sapiens_hsa000520.96695166
52Histidine metabolism_Homo sapiens_hsa003400.96509399
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94759760
54Adherens junction_Homo sapiens_hsa045200.94703865
55Non-small cell lung cancer_Homo sapiens_hsa052230.92952861
56ErbB signaling pathway_Homo sapiens_hsa040120.92763195
57VEGF signaling pathway_Homo sapiens_hsa043700.92171103
58N-Glycan biosynthesis_Homo sapiens_hsa005100.91610742
59Renin-angiotensin system_Homo sapiens_hsa046140.90419233
60Toxoplasmosis_Homo sapiens_hsa051450.90381301
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90049779
62Protein digestion and absorption_Homo sapiens_hsa049740.88496307
63Glycerolipid metabolism_Homo sapiens_hsa005610.87606696
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86865867
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85654859
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84322831
67Pancreatic cancer_Homo sapiens_hsa052120.83493091
68Lysine degradation_Homo sapiens_hsa003100.83363885
69Thyroid cancer_Homo sapiens_hsa052160.81580711
70Fatty acid metabolism_Homo sapiens_hsa012120.81385883
71Leishmaniasis_Homo sapiens_hsa051400.80843640
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80820452
73Arginine biosynthesis_Homo sapiens_hsa002200.80737719
74mTOR signaling pathway_Homo sapiens_hsa041500.80620990
75Sphingolipid metabolism_Homo sapiens_hsa006000.80488622
76Shigellosis_Homo sapiens_hsa051310.77496935
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.76456685
78Thyroid hormone synthesis_Homo sapiens_hsa049180.75674222
79GnRH signaling pathway_Homo sapiens_hsa049120.75351910
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.75142376
81Pentose phosphate pathway_Homo sapiens_hsa000300.74598242
82Vitamin digestion and absorption_Homo sapiens_hsa049770.74472546
83Focal adhesion_Homo sapiens_hsa045100.74067365
84Amoebiasis_Homo sapiens_hsa051460.73634421
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.73414631
86Butanoate metabolism_Homo sapiens_hsa006500.72351481
87Measles_Homo sapiens_hsa051620.72206595
88Platelet activation_Homo sapiens_hsa046110.71776053
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.71761380
90Choline metabolism in cancer_Homo sapiens_hsa052310.71695705
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71671612
92Malaria_Homo sapiens_hsa051440.70622475
93Small cell lung cancer_Homo sapiens_hsa052220.69663157
94Proteoglycans in cancer_Homo sapiens_hsa052050.68684304
95Sulfur relay system_Homo sapiens_hsa041220.68529766
96Glioma_Homo sapiens_hsa052140.68270968
97Primary immunodeficiency_Homo sapiens_hsa053400.67740840
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.67711092
99Chemokine signaling pathway_Homo sapiens_hsa040620.67341134
100Apoptosis_Homo sapiens_hsa042100.66965111
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66525796
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65743759
103Pertussis_Homo sapiens_hsa051330.65738852
104Inositol phosphate metabolism_Homo sapiens_hsa005620.65567846
105Legionellosis_Homo sapiens_hsa051340.65062665
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64887133
107Fructose and mannose metabolism_Homo sapiens_hsa000510.64265701
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63817861
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63572658
110HIF-1 signaling pathway_Homo sapiens_hsa040660.63418549
111Complement and coagulation cascades_Homo sapiens_hsa046100.62540188
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62442021
113Insulin signaling pathway_Homo sapiens_hsa049100.62353339
114beta-Alanine metabolism_Homo sapiens_hsa004100.62103082
115Antigen processing and presentation_Homo sapiens_hsa046120.61952346
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61666206
117Carbon metabolism_Homo sapiens_hsa012000.61255988
118Viral carcinogenesis_Homo sapiens_hsa052030.61126934
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.60960854
120AMPK signaling pathway_Homo sapiens_hsa041520.60615094
121Endometrial cancer_Homo sapiens_hsa052130.60348893
122MicroRNAs in cancer_Homo sapiens_hsa052060.60281934
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59440677
124T cell receptor signaling pathway_Homo sapiens_hsa046600.58429370
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58377297
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58060925
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57934897
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57368027
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.56965635
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56642031
131Type II diabetes mellitus_Homo sapiens_hsa049300.56547958
132Propanoate metabolism_Homo sapiens_hsa006400.56157649
133Estrogen signaling pathway_Homo sapiens_hsa049150.55877357
134Colorectal cancer_Homo sapiens_hsa052100.55222868
135Viral myocarditis_Homo sapiens_hsa054160.54190363
136Prolactin signaling pathway_Homo sapiens_hsa049170.54085871
137HTLV-I infection_Homo sapiens_hsa051660.53979647
138Phagosome_Homo sapiens_hsa041450.53882591
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53561424
140ECM-receptor interaction_Homo sapiens_hsa045120.53422424
141Herpes simplex infection_Homo sapiens_hsa051680.53410731
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52915103
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52022437
144Selenocompound metabolism_Homo sapiens_hsa004500.51823506
145Tuberculosis_Homo sapiens_hsa051520.49535388
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49010105

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