CANX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.94424305
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.61952823
3COPI coating of Golgi vesicle (GO:0048205)5.22305654
4Golgi transport vesicle coating (GO:0048200)5.22305654
5nuclear pore complex assembly (GO:0051292)5.01506171
6ER overload response (GO:0006983)4.87337726
7nuclear pore organization (GO:0006999)4.79252380
8protein retention in ER lumen (GO:0006621)4.67397066
9IMP biosynthetic process (GO:0006188)4.57353913
10DNA unwinding involved in DNA replication (GO:0006268)4.20200482
11cellular response to ATP (GO:0071318)4.13840412
12pore complex assembly (GO:0046931)4.10681379
13cell adhesion mediated by integrin (GO:0033627)4.07351463
14embryonic process involved in female pregnancy (GO:0060136)4.05948880
15cullin deneddylation (GO:0010388)4.01860681
16negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.91404817
17regulation of translational fidelity (GO:0006450)3.90414195
18mitotic chromosome condensation (GO:0007076)3.82742904
19RNA-dependent DNA replication (GO:0006278)3.78037276
20replication fork processing (GO:0031297)3.76159228
21IMP metabolic process (GO:0046040)3.69420020
22regulation of RNA export from nucleus (GO:0046831)3.61209233
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52187216
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.50975190
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50975190
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50975190
27protein deneddylation (GO:0000338)3.45588232
28glucocorticoid receptor signaling pathway (GO:0042921)3.45055390
29COPII vesicle coating (GO:0048208)3.43208165
30sequestering of metal ion (GO:0051238)3.39279307
31hemidesmosome assembly (GO:0031581)3.37859794
32regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.34308978
33regulation of mitotic spindle organization (GO:0060236)3.34186221
34viral mRNA export from host cell nucleus (GO:0046784)3.32522609
35regulation of nucleobase-containing compound transport (GO:0032239)3.31919717
36paraxial mesoderm development (GO:0048339)3.29906391
37regulation of mitotic spindle checkpoint (GO:1903504)3.27013470
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27013470
39DNA strand renaturation (GO:0000733)3.24544592
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22674490
41maturation of 5.8S rRNA (GO:0000460)3.22122229
42kinetochore organization (GO:0051383)3.20804578
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.20633915
44skin morphogenesis (GO:0043589)3.19864315
45heart process (GO:0003015)3.16937167
46heart contraction (GO:0060047)3.16937167
47poly(A)+ mRNA export from nucleus (GO:0016973)3.14266485
48regulation of DNA endoreduplication (GO:0032875)3.12517103
49meiotic chromosome segregation (GO:0045132)3.12479888
50nucleobase biosynthetic process (GO:0046112)3.09175494
51DNA double-strand break processing (GO:0000729)3.08427890
52DNA ligation (GO:0006266)3.01557245
53purine nucleobase biosynthetic process (GO:0009113)3.01502054
54cellular protein complex localization (GO:0034629)3.01405646
55CENP-A containing nucleosome assembly (GO:0034080)2.98657083
56protein export from nucleus (GO:0006611)2.97736785
57regulation of glucokinase activity (GO:0033131)2.95966925
58regulation of hexokinase activity (GO:1903299)2.95966925
59regulation of DNA-templated transcription, initiation (GO:2000142)2.95007465
60peptidyl-proline hydroxylation (GO:0019511)2.92358574
61protein maturation by protein folding (GO:0022417)2.92350390
62chromatin remodeling at centromere (GO:0031055)2.91419097
63protein localization to endosome (GO:0036010)2.89855673
64activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.88973702
65desmosome organization (GO:0002934)2.88326216
66protein hydroxylation (GO:0018126)2.87467672
67negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.87369324
68ribosome assembly (GO:0042255)2.87298740
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87086491
70regulation of glucose import in response to insulin stimulus (GO:2001273)2.85549538
71metanephric mesenchyme development (GO:0072075)2.83418903
72positive regulation of nuclease activity (GO:0032075)2.83146636
73protein localization to chromosome, centromeric region (GO:0071459)2.83119239
74establishment of chromosome localization (GO:0051303)2.82902360
75regulation of sister chromatid cohesion (GO:0007063)2.82548674
76mitotic cytokinesis (GO:0000281)2.81459798
77negative regulation of phagocytosis (GO:0050765)2.80906996
78ER-nucleus signaling pathway (GO:0006984)2.78952006
79DNA topological change (GO:0006265)2.78817652
80dosage compensation (GO:0007549)2.78442081
81negative regulation of dendrite morphogenesis (GO:0050774)2.76826966
82iron ion import (GO:0097286)2.76123076
83DNA duplex unwinding (GO:0032508)2.75947120
84endoplasmic reticulum unfolded protein response (GO:0030968)2.75746218
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.74790159
86ganglion development (GO:0061548)2.74669834
87epithelial cell-cell adhesion (GO:0090136)2.74642954
88regulation of centrosome duplication (GO:0010824)2.74331039
89cellular response to hepatocyte growth factor stimulus (GO:0035729)2.74261435
90response to hepatocyte growth factor (GO:0035728)2.74261435
91protein complex localization (GO:0031503)2.73926900
92mitotic sister chromatid segregation (GO:0000070)2.73907397
93histone H2B ubiquitination (GO:0033523)2.73511823
94protein K6-linked ubiquitination (GO:0085020)2.73243540
95negative regulation of mast cell activation (GO:0033004)2.73221967
96negative regulation of DNA repair (GO:0045738)2.72037840
97positive regulation of cell cycle checkpoint (GO:1901978)2.71704847
98cytoskeleton-dependent cytokinesis (GO:0061640)2.71360691
99protein localization to microtubule (GO:0035372)2.70680840
100protein refolding (GO:0042026)2.70337344
101gap junction assembly (GO:0016264)2.70188352
102corticosteroid receptor signaling pathway (GO:0031958)2.69088231
103production of molecular mediator involved in inflammatory response (GO:0002532)2.67596170
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66287857
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.66287857
106* chaperone-mediated protein folding (GO:0061077)2.65726581
107myoblast differentiation (GO:0045445)2.65504321
108negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.63916367
109NLS-bearing protein import into nucleus (GO:0006607)2.62176680
110kidney mesenchyme development (GO:0072074)2.61907252
111negative regulation of glycogen biosynthetic process (GO:0045719)2.61554086
112cell-substrate junction assembly (GO:0007044)2.61501930
113retina vasculature morphogenesis in camera-type eye (GO:0061299)2.61226826
114mitotic nuclear envelope disassembly (GO:0007077)2.60820212
115morphogenesis of an epithelial sheet (GO:0002011)2.60612880
116hippo signaling (GO:0035329)2.59671707
117DNA geometric change (GO:0032392)2.59338298
118midgut development (GO:0007494)2.58772055
119proline biosynthetic process (GO:0006561)2.58273027
120myoblast migration (GO:0051451)2.57115193
121regulation of nuclease activity (GO:0032069)2.56239229
122cellular response to unfolded protein (GO:0034620)2.55550428
123notochord development (GO:0030903)2.55489320
124telomere maintenance via recombination (GO:0000722)2.55366747
125regulation of centriole replication (GO:0046599)2.53698877
126regulation of centrosome cycle (GO:0046605)2.50464552
127regulation of protein polyubiquitination (GO:1902914)2.49959310
128adherens junction assembly (GO:0034333)2.49501922
129cytoplasmic mRNA processing body assembly (GO:0033962)2.49109638
130nuclear envelope disassembly (GO:0051081)2.48500066
131membrane disassembly (GO:0030397)2.48500066
132mitotic recombination (GO:0006312)2.48232019
133nucleotide transmembrane transport (GO:1901679)2.47877662
134regulation of spindle organization (GO:0090224)2.47746699
135histone-serine phosphorylation (GO:0035404)2.46935668
136inositol phosphate catabolic process (GO:0071545)2.46721345
137membrane protein ectodomain proteolysis (GO:0006509)2.46559161
138mitotic sister chromatid cohesion (GO:0007064)2.45277808
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45190155
140telomere maintenance via semi-conservative replication (GO:0032201)2.44669978
141vesicle coating (GO:0006901)2.44211425
142chondrocyte development (GO:0002063)2.44112751
143snRNA processing (GO:0016180)2.42756475
144telomere maintenance via telomerase (GO:0007004)2.41583455
145activation of Rac GTPase activity (GO:0032863)2.41001988
146mRNA export from nucleus (GO:0006406)2.40404182
147nucleotide-excision repair, DNA gap filling (GO:0006297)2.39618025
148negative regulation of striated muscle cell apoptotic process (GO:0010664)2.39271307
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.38991956
150positive regulation of mitochondrial fission (GO:0090141)2.38453288
151mitotic metaphase plate congression (GO:0007080)2.38311123
152basement membrane organization (GO:0071711)2.37819658
153chromosome condensation (GO:0030261)2.37756182
154positive regulation of chromosome segregation (GO:0051984)2.37387558
155* protein N-linked glycosylation via asparagine (GO:0018279)2.36561138
156RNA stabilization (GO:0043489)2.35828976
157mRNA stabilization (GO:0048255)2.35828976
158transcription initiation from RNA polymerase I promoter (GO:0006361)2.35648211
159regulation of double-strand break repair via homologous recombination (GO:0010569)2.35623396
160negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.34865229
161mRNA cleavage (GO:0006379)2.34860333
162establishment of integrated proviral latency (GO:0075713)2.34817063
163* peptidyl-asparagine modification (GO:0018196)2.34721354
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34510394
165cell-substrate adherens junction assembly (GO:0007045)2.33730823
166focal adhesion assembly (GO:0048041)2.33730823
167protein localization to kinetochore (GO:0034501)2.33093548
168glomerular visceral epithelial cell development (GO:0072015)2.32742015
169sister chromatid segregation (GO:0000819)2.32339007
170bundle of His cell to Purkinje myocyte communication (GO:0086069)2.30734361
171response to epidermal growth factor (GO:0070849)2.30307958
172establishment of apical/basal cell polarity (GO:0035089)2.29979706
173cellular copper ion homeostasis (GO:0006878)2.29390772
174regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.28451792
175response to endoplasmic reticulum stress (GO:0034976)2.28047049
176non-recombinational repair (GO:0000726)2.27995090
177double-strand break repair via nonhomologous end joining (GO:0006303)2.27995090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.61266340
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.36270080
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.03552211
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.02841797
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53758377
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37124005
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.19538813
8CLOCK_20551151_ChIP-Seq_293T_Human3.13816378
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05476431
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.05239860
11ELK1_19687146_ChIP-ChIP_HELA_Human3.00011307
12ZNF263_19887448_ChIP-Seq_K562_Human2.83934696
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67895992
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44148931
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43793154
16* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.10225977
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.09073634
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06406438
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03970973
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.03704829
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.03527544
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03447532
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.98424443
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96414549
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95647038
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.95064242
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92568219
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91018738
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91005008
30EWS_26573619_Chip-Seq_HEK293_Human1.89495585
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88655703
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.87661214
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86080935
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81923742
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78541889
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.77886344
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.74380457
38AR_21909140_ChIP-Seq_LNCAP_Human1.72262183
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71186805
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70408183
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65656687
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65487374
43FUS_26573619_Chip-Seq_HEK293_Human1.64517266
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61845446
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60110584
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60090604
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58737161
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58716286
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58437221
50* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54775984
51CHD1_26751641_Chip-Seq_LNCaP_Human1.51823520
52* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49840016
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49445595
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49337014
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.47580902
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47245423
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46554094
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45735065
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42628273
60VDR_23849224_ChIP-Seq_CD4+_Human1.40273307
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.39185872
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39058142
63TFEB_21752829_ChIP-Seq_HELA_Human1.37879786
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37508983
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36790680
66* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34838060
67* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34829176
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33634151
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.33610575
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33357596
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31434000
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31361815
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30288052
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29534644
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28602689
76* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27616738
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25783203
78DCP1A_22483619_ChIP-Seq_HELA_Human1.25101387
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25055953
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24895684
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24818642
82* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24394278
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22239859
84GATA4_21415370_ChIP-Seq_HL-1_Mouse1.22009510
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19948589
86IGF1R_20145208_ChIP-Seq_DFB_Human1.19749936
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19443671
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19142952
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.18823414
90ATF3_27146783_Chip-Seq_COLON_Human1.18584158
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17738279
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17256182
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.16099466
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15323223
95BRD4_25478319_ChIP-Seq_HGPS_Human1.14866833
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14477772
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.14077621
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13889022
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.13593377
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13314464
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11630974
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11630974
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07437202
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07300969
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06837627
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05938466
107* NANOG_21062744_ChIP-ChIP_HESCs_Human1.05732092
108* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05237739
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03922191
110* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03716095
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.02575821
112* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01763650
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99737328
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99274558
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.99189643
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98837641
117ESR1_21235772_ChIP-Seq_MCF-7_Human0.98805584
118GATA6_25053715_ChIP-Seq_YYC3_Human0.98439808
119FOXP3_21729870_ChIP-Seq_TREG_Human0.97891878
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.97668631
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97374844
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96887836
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95691705
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95618251
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95509675
126PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94849049
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.94772239
128CJUN_26792858_Chip-Seq_BT549_Human0.94512801
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94268157
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94104218
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93482117
132P300_19829295_ChIP-Seq_ESCs_Human0.92701699
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92630504
134HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91849306
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.91586075
136P53_22387025_ChIP-Seq_ESCs_Mouse0.91544872
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91535950
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90794498
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90772882
140* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89640713
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89546433
142SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89090384
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88928174
144GATA1_22025678_ChIP-Seq_K562_Human0.88734441
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88717996
146* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88528351
147GBX2_23144817_ChIP-Seq_PC3_Human0.88314592
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87941829
149RACK7_27058665_Chip-Seq_MCF-7_Human0.87730250
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87554281
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87504834
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87504834
153TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87484835
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.87435902
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86289672
156* JUN_21703547_ChIP-Seq_K562_Human0.86243718
157P300_18555785_Chip-Seq_ESCs_Mouse0.86159076
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.85777531
159IRF8_22096565_ChIP-ChIP_GC-B_Human0.85293461
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.84733489
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84372003
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83421046
163* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83368303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.11241427
2MP0008057_abnormal_DNA_replication3.67345454
3MP0010234_abnormal_vibrissa_follicle3.65998445
4MP0005171_absent_coat_pigmentation3.58446965
5MP0006054_spinal_hemorrhage3.04122549
6MP0008438_abnormal_cutaneous_collagen2.63513904
7MP0005367_renal/urinary_system_phenotyp2.56137009
8MP0000516_abnormal_urinary_system2.56137009
9MP0003123_paternal_imprinting2.44156683
10MP0005257_abnormal_intraocular_pressure2.37845625
11MP0004782_abnormal_surfactant_physiolog2.30254315
12MP0009697_abnormal_copulation2.26933123
13MP0002009_preneoplasia2.22034765
14MP0010094_abnormal_chromosome_stability2.17913386
15MP0003121_genomic_imprinting2.15942568
16MP0003122_maternal_imprinting2.07454479
17MP0005408_hypopigmentation2.03241700
18MP0010352_gastrointestinal_tract_polyps1.99746571
19MP0008007_abnormal_cellular_replicative1.98404075
20MP0005503_abnormal_tendon_morphology1.97536851
21MP0004233_abnormal_muscle_weight1.97482127
22MP0003693_abnormal_embryo_hatching1.81697091
23MP0010386_abnormal_urinary_bladder1.78492797
24MP0004957_abnormal_blastocyst_morpholog1.77288211
25MP0001177_atelectasis1.74108606
26MP0003091_abnormal_cell_migration1.72045406
27MP0004272_abnormal_basement_membrane1.69886830
28MP0003890_abnormal_embryonic-extraembry1.69270280
29MP0009053_abnormal_anal_canal1.69177652
30MP0001986_abnormal_taste_sensitivity1.63120483
31MP0004185_abnormal_adipocyte_glucose1.62306250
32MP0000372_irregular_coat_pigmentation1.61091346
33MP0010678_abnormal_skin_adnexa1.57550795
34MP0002876_abnormal_thyroid_physiology1.54481898
35MP0005409_darkened_coat_color1.53597634
36MP0003941_abnormal_skin_development1.51730242
37MP0000566_synostosis1.51361329
38MP0000579_abnormal_nail_morphology1.47892217
39MP0009780_abnormal_chondrocyte_physiolo1.47675147
40MP0003943_abnormal_hepatobiliary_system1.47578740
41MP0003786_premature_aging1.44690866
42MP0002697_abnormal_eye_size1.40974656
43MP0008058_abnormal_DNA_repair1.40800210
44MP0003950_abnormal_plasma_membrane1.39641909
45MP0010307_abnormal_tumor_latency1.38557969
46MP0003077_abnormal_cell_cycle1.38014309
47MP0008932_abnormal_embryonic_tissue1.35683821
48MP0002163_abnormal_gland_morphology1.31997890
49MP0004197_abnormal_fetal_growth/weight/1.31649420
50MP0000428_abnormal_craniofacial_morphol1.30992967
51MP0008877_abnormal_DNA_methylation1.28998164
52MP0000762_abnormal_tongue_morphology1.28100737
53MP0003787_abnormal_imprinting1.27135092
54MP0001849_ear_inflammation1.25187093
55MP0002796_impaired_skin_barrier1.24206554
56MP0003566_abnormal_cell_adhesion1.24087288
57MP0000015_abnormal_ear_pigmentation1.24021451
58MP0004264_abnormal_extraembryonic_tissu1.21223196
59MP0002080_prenatal_lethality1.20831776
60MP0003453_abnormal_keratinocyte_physiol1.18819854
61MP0005451_abnormal_body_composition1.17673758
62MP0004134_abnormal_chest_morphology1.17614078
63MP0009672_abnormal_birth_weight1.17574921
64MP0005379_endocrine/exocrine_gland_phen1.17457959
65MP0003567_abnormal_fetal_cardiomyocyte1.17109932
66MP0002092_abnormal_eye_morphology1.17065525
67MP0003705_abnormal_hypodermis_morpholog1.16590870
68MP0002085_abnormal_embryonic_tissue1.14166935
69MP0002160_abnormal_reproductive_system1.13993336
70MP0003279_aneurysm1.12200694
71MP0000537_abnormal_urethra_morphology1.12061096
72MP0003111_abnormal_nucleus_morphology1.10375693
73MP0005621_abnormal_cell_physiology1.10368665
74MP0001299_abnormal_eye_distance/1.09976229
75MP0005645_abnormal_hypothalamus_physiol1.09508687
76MP0009384_cardiac_valve_regurgitation1.08278347
77MP0001661_extended_life_span1.07106757
78MP0005508_abnormal_skeleton_morphology1.06938676
79MP0010368_abnormal_lymphatic_system1.06789650
80MP0005501_abnormal_skin_physiology1.05766460
81MP0003172_abnormal_lysosome_physiology1.05672422
82MP0001186_pigmentation_phenotype1.04413539
83MP0000627_abnormal_mammary_gland1.01837938
84MP0000350_abnormal_cell_proliferation1.00984255
85MP0004858_abnormal_nervous_system1.00631865
86MP0005248_abnormal_Harderian_gland0.99328259
87MP0000681_abnormal_thyroid_gland0.98852791
88MP0000733_abnormal_muscle_development0.98754612
89MP0000383_abnormal_hair_follicle0.98093234
90MP0000462_abnormal_digestive_system0.97860425
91MP0003385_abnormal_body_wall0.97065450
92MP0005623_abnormal_meninges_morphology0.96748924
93MP0005389_reproductive_system_phenotype0.96668946
94MP0002751_abnormal_autonomic_nervous0.96562445
95MP0005023_abnormal_wound_healing0.96459552
96MP0003221_abnormal_cardiomyocyte_apopto0.96276807
97MP0002086_abnormal_extraembryonic_tissu0.96243332
98MP0005197_abnormal_uvea_morphology0.95505438
99MP0003984_embryonic_growth_retardation0.94956086
100MP0000534_abnormal_ureter_morphology0.94951473
101MP0001672_abnormal_embryogenesis/_devel0.94916198
102MP0005380_embryogenesis_phenotype0.94916198
103MP0003937_abnormal_limbs/digits/tail_de0.94649443
104MP0001697_abnormal_embryo_size0.94227022
105MP0000377_abnormal_hair_follicle0.93494017
106MP0003935_abnormal_craniofacial_develop0.92138019
107MP0002088_abnormal_embryonic_growth/wei0.91370866
108MP0005076_abnormal_cell_differentiation0.91160709
109MP0000432_abnormal_head_morphology0.90389245
110MP0003755_abnormal_palate_morphology0.90382987
111MP0005384_cellular_phenotype0.89401987
112MP0001216_abnormal_epidermal_layer0.89377468
113MP0002060_abnormal_skin_morphology0.89318390
114MP0002098_abnormal_vibrissa_morphology0.89149788
115MP0001730_embryonic_growth_arrest0.88657627
116MP0001542_abnormal_bone_strength0.88320037
117MP0005275_abnormal_skin_tensile0.87248300
118MP0003868_abnormal_feces_composition0.87236593
119MP0010030_abnormal_orbit_morphology0.86990001
120MP0003315_abnormal_perineum_morphology0.86883917
121MP0005187_abnormal_penis_morphology0.86277972
122MP0002396_abnormal_hematopoietic_system0.86217524
123MP0002133_abnormal_respiratory_system0.86009928
124MP0005388_respiratory_system_phenotype0.86009928
125MP0001879_abnormal_lymphatic_vessel0.85819271
126MP0002295_abnormal_pulmonary_circulatio0.85159261
127MP0003942_abnormal_urinary_system0.84419639
128MP0002166_altered_tumor_susceptibility0.84070120
129MP0002928_abnormal_bile_duct0.81623110
130MP0000467_abnormal_esophagus_morphology0.80537897
131MP0000003_abnormal_adipose_tissue0.80278730
132MP0004808_abnormal_hematopoietic_stem0.79424558
133MP0002938_white_spotting0.79371174
134MP0000747_muscle_weakness0.79022944
135MP0003115_abnormal_respiratory_system0.78451328
136MP0002084_abnormal_developmental_patter0.78382523
137MP0003329_amyloid_beta_deposits0.78280081
138MP0010630_abnormal_cardiac_muscle0.77606436
139MP0001348_abnormal_lacrimal_gland0.75669059
140MP0005220_abnormal_exocrine_pancreas0.73936944
141MP0002115_abnormal_skeleton_extremities0.73599174
142MP0002109_abnormal_limb_morphology0.73253405
143MP0002177_abnormal_outer_ear0.72078133
144MP0003119_abnormal_digestive_system0.71698475
145MP0002896_abnormal_bone_mineralization0.71464547
146MP0001915_intracranial_hemorrhage0.70826609
147MP0003283_abnormal_digestive_organ0.69818965
148MP0002282_abnormal_trachea_morphology0.69349128
149MP0001119_abnormal_female_reproductive0.69239756
150MP0009703_decreased_birth_body0.69095383

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)3.93964840
2Abnormality of the anterior horn cell (HP:0006802)3.72510533
3Degeneration of anterior horn cells (HP:0002398)3.72510533
4Spinal cord lesions (HP:0100561)3.30169978
5Syringomyelia (HP:0003396)3.30169978
6Papillary thyroid carcinoma (HP:0002895)3.28380819
7Termporal pattern (HP:0011008)3.27351415
8Insidious onset (HP:0003587)3.27351415
9Thyroid carcinoma (HP:0002890)3.24065655
10Cutaneous melanoma (HP:0012056)3.17357949
11Hyperacusis (HP:0010780)3.05341314
12Tongue fasciculations (HP:0001308)3.00244678
13Protrusio acetabuli (HP:0003179)2.98621031
14Ankyloglossia (HP:0010296)2.97651000
1511 pairs of ribs (HP:0000878)2.94859404
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.88191458
17Osteolytic defects of the hand bones (HP:0009699)2.88191458
18Arterial tortuosity (HP:0005116)2.86584410
19Pancreatic islet-cell hyperplasia (HP:0004510)2.77799737
20Deep philtrum (HP:0002002)2.71222348
21Abnormality of oral frenula (HP:0000190)2.70537516
22Hypothermia (HP:0002045)2.70188028
23Abnormality of incisor morphology (HP:0011063)2.67476171
24Subacute progressive viral hepatitis (HP:0006572)2.63486737
25Vascular tortuosity (HP:0004948)2.58389188
26Mesomelia (HP:0003027)2.57161266
27Muscle fibrillation (HP:0010546)2.55745921
28Insomnia (HP:0100785)2.55471345
29Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54626621
30Flat acetabular roof (HP:0003180)2.51483623
31Missing ribs (HP:0000921)2.47410913
32Atrophic scars (HP:0001075)2.46748875
33Cervical subluxation (HP:0003308)2.46380528
34Spinal muscular atrophy (HP:0007269)2.45713572
35Increased nuchal translucency (HP:0010880)2.42152704
36Ulnar bowing (HP:0003031)2.40368336
37Type I transferrin isoform profile (HP:0003642)2.39401287
38Abnormal foot bone ossification (HP:0010675)2.38329450
39Cortical dysplasia (HP:0002539)2.36121326
40Osteomalacia (HP:0002749)2.34192062
41Neoplasm of the adrenal gland (HP:0100631)2.33102236
42Vertebral arch anomaly (HP:0008438)2.31878359
43Neoplasm of the adrenal cortex (HP:0100641)2.31258330
44Abnormality of the nasal septum (HP:0000419)2.28490805
45Chromsome breakage (HP:0040012)2.28462075
46Abnormal pancreas size (HP:0012094)2.27215134
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.26668973
48Vertebral hypoplasia (HP:0008417)2.26668973
49Volvulus (HP:0002580)2.26627154
50Cystic hygroma (HP:0000476)2.25315035
51Rectal fistula (HP:0100590)2.21383639
52Rectovaginal fistula (HP:0000143)2.21383639
53Alveolar cell carcinoma (HP:0006519)2.19762318
54Vertebral compression fractures (HP:0002953)2.17665280
55Back pain (HP:0003418)2.16488555
56Overlapping toe (HP:0001845)2.15998748
57Short humerus (HP:0005792)2.15534855
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.14846708
59Abnormal hair whorl (HP:0010721)2.14787139
60Relative macrocephaly (HP:0004482)2.13351324
61Abnormality of the frontal sinuses (HP:0002687)2.12751478
62Selective tooth agenesis (HP:0001592)2.10422863
63Bladder diverticulum (HP:0000015)2.10001636
64Long clavicles (HP:0000890)2.09486087
65Embryonal renal neoplasm (HP:0011794)2.09454730
66Prominent metopic ridge (HP:0005487)2.08996628
67Abnormality of dentin (HP:0010299)2.08544211
68Nephroblastoma (Wilms tumor) (HP:0002667)2.07087764
69Overriding aorta (HP:0002623)2.06952757
70Stillbirth (HP:0003826)2.05795111
71Bilateral sensorineural hearing impairment (HP:0008619)2.05510606
72Neoplasm of the thyroid gland (HP:0100031)2.04966608
73Abnormality of the distal phalanges of the toes (HP:0010182)2.02603146
74Meningioma (HP:0002858)2.01856138
75Spastic diplegia (HP:0001264)2.00859841
76Mild short stature (HP:0003502)2.00060039
77Renal duplication (HP:0000075)2.00008475
78Intestinal fistula (HP:0100819)1.98064782
79Progressive sensorineural hearing impairment (HP:0000408)1.97133578
80Shallow orbits (HP:0000586)1.95438732
81Neoplasm of the tracheobronchial system (HP:0100552)1.94884077
82Microglossia (HP:0000171)1.94555969
83Aplasia/hypoplasia of the humerus (HP:0006507)1.94073601
84Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92961669
85Advanced eruption of teeth (HP:0006288)1.92540417
86Wormian bones (HP:0002645)1.92323096
87Tetraparesis (HP:0002273)1.92081745
88Right ventricular cardiomyopathy (HP:0011663)1.91963070
89Birth length less than 3rd percentile (HP:0003561)1.90851481
90Heterotopia (HP:0002282)1.90785832
91Hammertoe (HP:0001765)1.90525668
92Abnormality of the ischium (HP:0003174)1.90190012
93Proximal placement of thumb (HP:0009623)1.89857868
94Elfin facies (HP:0004428)1.89850937
95Broad face (HP:0000283)1.89319562
96Breech presentation (HP:0001623)1.88879173
97Ankle contracture (HP:0006466)1.88774444
98Carpal synostosis (HP:0009702)1.87003278
99Absent frontal sinuses (HP:0002688)1.85779883
100Abnormality of the metopic suture (HP:0005556)1.85548253
101Short middle phalanx of the 5th finger (HP:0004220)1.84886576
102Natal tooth (HP:0000695)1.84869509
103Disproportionate short-trunk short stature (HP:0003521)1.84683333
104Ectopic kidney (HP:0000086)1.84514773
105Renovascular hypertension (HP:0100817)1.82696356
106Heterochromia iridis (HP:0001100)1.82290581
107Arnold-Chiari malformation (HP:0002308)1.81580002
108Abnormal protein glycosylation (HP:0012346)1.80550571
109Abnormal glycosylation (HP:0012345)1.80550571
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80550571
111Abnormal protein N-linked glycosylation (HP:0012347)1.80550571
112Abnormality of the labia minora (HP:0012880)1.80498118
113Cubitus valgus (HP:0002967)1.80169901
114Intestinal atresia (HP:0011100)1.78452884
115Patellar dislocation (HP:0002999)1.78340358
116Deviation of the thumb (HP:0009603)1.78252524
117Short nail (HP:0001799)1.78113421
118Cerebral inclusion bodies (HP:0100314)1.77718972
119Absent eyebrow (HP:0002223)1.77497608
120Abnormal biliary tract morphology (HP:0012440)1.74998547
121Fragile skin (HP:0001030)1.74459587
122Abnormality of chromosome stability (HP:0003220)1.74060618
123Epiphyseal dysplasia (HP:0002656)1.73857039
124Abnormality of carpal bone ossification (HP:0006257)1.73167454
125True hermaphroditism (HP:0010459)1.72693897
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72099692
127Patent foramen ovale (HP:0001655)1.72053203
128Achilles tendon contracture (HP:0001771)1.71109760
129Mitral valve prolapse (HP:0001634)1.70986794
130Aplasia/Hypoplasia of the fovea (HP:0008060)1.70514347
131Hypoplasia of the fovea (HP:0007750)1.70514347
132Neonatal short-limb short stature (HP:0008921)1.69919872
133Dysmetric saccades (HP:0000641)1.69769330
134Ovarian neoplasm (HP:0100615)1.69660005
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69303226
136Metaphyseal dysplasia (HP:0100255)1.69113186
137Abnormality of the intrinsic pathway (HP:0010989)1.68926704
138Aortic dissection (HP:0002647)1.68606623
139Aplasia involving bones of the extremities (HP:0009825)1.68595654
140Aplasia involving bones of the upper limbs (HP:0009823)1.68595654
141Aplasia of the phalanges of the hand (HP:0009802)1.68595654
142Abnormality of the pancreatic islet cells (HP:0006476)1.68427178
143Abnormality of endocrine pancreas physiology (HP:0012093)1.68427178
144Abnormal ossification of hand bones (HP:0005921)1.67920461
145Abnormal lung lobation (HP:0002101)1.67509996
146Increased number of teeth (HP:0011069)1.66336639
147Mitral stenosis (HP:0001718)1.65920411
148Abnormality of the acetabulum (HP:0003170)1.65580679
149Rhizomelia (HP:0008905)1.64137676
150Leiomyosarcoma (HP:0100243)1.63422525
151Uterine leiomyosarcoma (HP:0002891)1.63422525
152Abnormality of the calcaneus (HP:0008364)1.62906714
153Impaired pain sensation (HP:0007328)1.62186472
154Abnormality of pain sensation (HP:0010832)1.62186472
155Increased mean platelet volume (HP:0011877)1.62105783
156Midface retrusion (HP:0011800)1.61927004
157Adrenal hypoplasia (HP:0000835)1.61290804
158Autoamputation (HP:0001218)1.60797340
159Abnormal delivery (HP:0001787)1.60557876
160Premature rupture of membranes (HP:0001788)1.60291138
161Elbow flexion contracture (HP:0002987)1.60108482
162Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59949853
163Abnormality of the incisor (HP:0000676)1.58381205
164Pancreatic fibrosis (HP:0100732)1.58366329
165Synostosis involving bones of the hand (HP:0004278)1.58159312
166Hepatoblastoma (HP:0002884)1.57928481
167Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57915342
168Vaginal fistula (HP:0004320)1.57320536
169Abnormality of the Achilles tendon (HP:0005109)1.57278398
170Hypoplasia of the odontoid process (HP:0003311)1.57151838
171Spinal cord compression (HP:0002176)1.57145938
172Hypoplastic toenails (HP:0001800)1.56432614
173Cerebral aneurysm (HP:0004944)1.56051944
174Hypopigmentation of the fundus (HP:0007894)1.55749658
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55039177
176Curly hair (HP:0002212)1.53822381
177Abnormality of the gastric mucosa (HP:0004295)1.52786873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.22411111
2ERBB33.86946009
3ZAK3.57996757
4CDK123.32829903
5AKT32.94329923
6MST1R2.87321276
7LATS22.75455843
8MAP3K142.74503163
9EEF2K2.69201965
10BCR2.48773930
11ICK2.38492350
12TRIB32.31275344
13PLK22.30537733
14TRPM72.22487316
15PLK32.13214026
16BRSK22.12546923
17MKNK12.06271782
18EIF2AK32.03009608
19SIK32.00270425
20SRPK11.96576610
21PASK1.94969954
22BMPR21.94599348
23STK38L1.92328239
24EIF2AK11.88515639
25NTRK11.88140702
26CDK81.87960197
27TSSK61.82117329
28PKN21.75692653
29CDC71.68590819
30SMG11.68042009
31PRPF4B1.61935021
32STK241.60168782
33MKNK21.55863441
34YES11.54692093
35SCYL21.53862543
36MST41.50421306
37CAMK1G1.50014126
38PLK41.48437790
39CAMK1D1.48340996
40TTN1.46786465
41NEK61.45723613
42PAK41.44156036
43NEK91.42410292
44NUAK11.42279915
45BRD41.37246382
46RIPK11.32673477
47NEK11.31736401
48PTK21.29192563
49SGK21.22517228
50CASK1.22293381
51DDR21.21327363
52PNCK1.17833656
53MTOR1.16497481
54BMPR1B1.15468431
55LATS11.15204544
56ERBB41.12312902
57RPS6KB11.10072054
58SIK11.05981235
59PAK21.03997166
60RPS6KB21.03290436
61STK31.02386163
62FGFR40.96993623
63KSR10.95890342
64MAP3K20.92264279
65ATR0.91067324
66VRK10.90777138
67KSR20.90235287
68MAP3K100.89690002
69RPS6KC10.88509307
70RPS6KL10.88509307
71RPS6KA60.87981927
72PDGFRB0.84091900
73MAP3K90.80677344
74BRSK10.79699035
75PIM10.79540872
76PIM20.78334345
77MOS0.78269254
78PLK10.77274953
79LIMK10.76815755
80RPS6KA40.76017233
81NEK20.75040691
82FGFR10.72969067
83CLK10.72566374
84INSRR0.72404928
85CHUK0.72382227
86MAP3K80.71550230
87IRAK40.70180524
88* ATM0.68643709
89EIF2AK20.68345295
90WEE10.67884365
91PIK3CA0.65743481
92ALK0.65528416
93CDC42BPA0.64917817
94CHEK20.64015207
95ARAF0.62216976
96MELK0.60240851
97LMTK20.59988790
98BUB10.59830933
99OBSCN0.59469248
100PRKCE0.59455733
101SGK30.58066991
102RPS6KA20.57884463
103RET0.57154822
104TESK10.56986015
105JAK30.56183253
106TAF10.56083859
107MAP3K30.55080033
108ACVR1B0.52388260
109EPHA20.50826695
110FLT30.50143534
111MYLK0.50053562
112SGK2230.49931820
113SGK4940.49931820
114ROCK20.49436404
115TGFBR10.48934292
116EPHB20.48731363
117AKT20.48190176
118RAF10.47247331
119PTK60.47235607
120TTK0.46943968
121MAPK100.46692884
122CHEK10.46565998
123* CSNK2A10.46044002
124MET0.45811191
125PDGFRA0.45499520
126PINK10.45471945
127MAP3K60.45298153
128PBK0.45071584
129FER0.44122144
130AURKB0.43143309
131TEC0.42956507
132CSNK1E0.41593439
133CDK180.40994761
134CDK70.39823002
135BRAF0.39658738
136CDK60.39262076
137CDK150.38368585
138MARK30.37804560
139STK100.34510847
140FGFR30.33779754
141TAOK20.33495084
142* CDK10.32884656
143CDK20.32319404
144STK40.30216716
145EPHA30.29524772
146* MAPK140.29030043
147MAPKAPK20.28456881
148IRAK30.28450302
149* CSNK2A20.28164907

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.24496042
2Mismatch repair_Homo sapiens_hsa034303.03982828
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62247363
4* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.47930391
5DNA replication_Homo sapiens_hsa030302.47395685
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19270326
7Proteasome_Homo sapiens_hsa030502.17502952
8Nucleotide excision repair_Homo sapiens_hsa034202.16604448
9Cell cycle_Homo sapiens_hsa041102.14837414
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.04786126
11RNA transport_Homo sapiens_hsa030132.01454576
12Homologous recombination_Homo sapiens_hsa034401.98182296
13Non-homologous end-joining_Homo sapiens_hsa034501.96266557
14N-Glycan biosynthesis_Homo sapiens_hsa005101.94312079
15Sulfur metabolism_Homo sapiens_hsa009201.90408077
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.87777930
17Base excision repair_Homo sapiens_hsa034101.82526680
18RNA degradation_Homo sapiens_hsa030181.80073468
19One carbon pool by folate_Homo sapiens_hsa006701.76457381
20Legionellosis_Homo sapiens_hsa051341.72437242
21Biosynthesis of amino acids_Homo sapiens_hsa012301.66835125
22Chronic myeloid leukemia_Homo sapiens_hsa052201.65840869
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64365359
24Vibrio cholerae infection_Homo sapiens_hsa051101.64019362
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62254583
26Type I diabetes mellitus_Homo sapiens_hsa049401.61823043
27mRNA surveillance pathway_Homo sapiens_hsa030151.60576157
28Fatty acid biosynthesis_Homo sapiens_hsa000611.51431416
29RNA polymerase_Homo sapiens_hsa030201.50018510
30Basal transcription factors_Homo sapiens_hsa030221.48961162
31Fanconi anemia pathway_Homo sapiens_hsa034601.44138417
32Pancreatic cancer_Homo sapiens_hsa052121.39922893
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31940224
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30136721
35TGF-beta signaling pathway_Homo sapiens_hsa043501.27204445
36Renal cell carcinoma_Homo sapiens_hsa052111.25928702
37Adherens junction_Homo sapiens_hsa045201.25570369
38p53 signaling pathway_Homo sapiens_hsa041151.23091266
39Spliceosome_Homo sapiens_hsa030401.22820525
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20660875
41Vitamin B6 metabolism_Homo sapiens_hsa007501.20303186
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20118310
43Prion diseases_Homo sapiens_hsa050201.18987898
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18826491
45Thyroid cancer_Homo sapiens_hsa052161.16796888
46Pentose phosphate pathway_Homo sapiens_hsa000301.16741607
47Carbon metabolism_Homo sapiens_hsa012001.16720080
48* Phagosome_Homo sapiens_hsa041451.16136824
49Lysine degradation_Homo sapiens_hsa003101.13659702
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13216153
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08715761
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08278145
53Non-small cell lung cancer_Homo sapiens_hsa052231.06472550
54Prostate cancer_Homo sapiens_hsa052151.05787823
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03649841
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03134184
57Hippo signaling pathway_Homo sapiens_hsa043901.01057117
58Glioma_Homo sapiens_hsa052141.00033152
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99784124
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99347772
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98183557
62ErbB signaling pathway_Homo sapiens_hsa040120.96624790
63* Thyroid hormone synthesis_Homo sapiens_hsa049180.93925438
64Melanoma_Homo sapiens_hsa052180.93719512
65Arachidonic acid metabolism_Homo sapiens_hsa005900.92533908
66MicroRNAs in cancer_Homo sapiens_hsa052060.92146865
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91142083
68Steroid biosynthesis_Homo sapiens_hsa001000.90467035
69Viral carcinogenesis_Homo sapiens_hsa052030.89185796
70Colorectal cancer_Homo sapiens_hsa052100.89158455
71Pyruvate metabolism_Homo sapiens_hsa006200.87519232
72Pyrimidine metabolism_Homo sapiens_hsa002400.87201751
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86975051
74Other glycan degradation_Homo sapiens_hsa005110.83448523
75ECM-receptor interaction_Homo sapiens_hsa045120.81460947
76Epstein-Barr virus infection_Homo sapiens_hsa051690.81173748
77Fatty acid metabolism_Homo sapiens_hsa012120.80600923
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80293394
79Fructose and mannose metabolism_Homo sapiens_hsa000510.80012069
80Arginine biosynthesis_Homo sapiens_hsa002200.79411527
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78607841
82Galactose metabolism_Homo sapiens_hsa000520.77858488
83Focal adhesion_Homo sapiens_hsa045100.77837321
84Insulin signaling pathway_Homo sapiens_hsa049100.75877619
85Endometrial cancer_Homo sapiens_hsa052130.75407992
86Estrogen signaling pathway_Homo sapiens_hsa049150.75077027
87Amoebiasis_Homo sapiens_hsa051460.74639373
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73929587
89Inositol phosphate metabolism_Homo sapiens_hsa005620.73749217
90mTOR signaling pathway_Homo sapiens_hsa041500.73573494
91Tight junction_Homo sapiens_hsa045300.73194853
92AMPK signaling pathway_Homo sapiens_hsa041520.73136373
93Selenocompound metabolism_Homo sapiens_hsa004500.71459029
94Rheumatoid arthritis_Homo sapiens_hsa053230.71319641
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69608472
96* Antigen processing and presentation_Homo sapiens_hsa046120.68966012
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66209942
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65874618
99Autoimmune thyroid disease_Homo sapiens_hsa053200.64267166
100Purine metabolism_Homo sapiens_hsa002300.63080358
101HIF-1 signaling pathway_Homo sapiens_hsa040660.61270347
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60778795
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57966012
104Proteoglycans in cancer_Homo sapiens_hsa052050.57439917
105Allograft rejection_Homo sapiens_hsa053300.57415657
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57137403
107Lysosome_Homo sapiens_hsa041420.56266184
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55432522
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.54735413
110Small cell lung cancer_Homo sapiens_hsa052220.54254581
111Protein digestion and absorption_Homo sapiens_hsa049740.54195741
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53822217
113Axon guidance_Homo sapiens_hsa043600.53709807
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.52690948
115Gap junction_Homo sapiens_hsa045400.52317528
116Basal cell carcinoma_Homo sapiens_hsa052170.52029174
117Oocyte meiosis_Homo sapiens_hsa041140.52022011
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51686986
119Measles_Homo sapiens_hsa051620.50952351
120Melanogenesis_Homo sapiens_hsa049160.50241728
121Hepatitis B_Homo sapiens_hsa051610.49292686
122Notch signaling pathway_Homo sapiens_hsa043300.49212485
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48427359
124Wnt signaling pathway_Homo sapiens_hsa043100.48412688
125Sphingolipid metabolism_Homo sapiens_hsa006000.46225991
126Systemic lupus erythematosus_Homo sapiens_hsa053220.45493260
127Renin-angiotensin system_Homo sapiens_hsa046140.44887105
128Herpes simplex infection_Homo sapiens_hsa051680.42135280
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41462412
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41306428
131Shigellosis_Homo sapiens_hsa051310.39656606
132Graft-versus-host disease_Homo sapiens_hsa053320.39378574
133Collecting duct acid secretion_Homo sapiens_hsa049660.38998094
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.38637116
135Alcoholism_Homo sapiens_hsa050340.35481575
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33795479
137* HTLV-I infection_Homo sapiens_hsa051660.32793099
138Viral myocarditis_Homo sapiens_hsa054160.32506141
139Influenza A_Homo sapiens_hsa051640.32418795
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32290126
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31986236
142Leishmaniasis_Homo sapiens_hsa051400.30875270
143NF-kappa B signaling pathway_Homo sapiens_hsa040640.30780883
144Glutathione metabolism_Homo sapiens_hsa004800.30460558
145Pathways in cancer_Homo sapiens_hsa052000.28995919
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28977762
147Apoptosis_Homo sapiens_hsa042100.27473763
148Salmonella infection_Homo sapiens_hsa051320.27093519
149FoxO signaling pathway_Homo sapiens_hsa040680.27029500
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27011534
151Bladder cancer_Homo sapiens_hsa052190.25871069
152Prolactin signaling pathway_Homo sapiens_hsa049170.25543944

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