CAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.77481788
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77481788
3regulation of B cell receptor signaling pathway (GO:0050855)4.40769214
4positive regulation of gamma-delta T cell activation (GO:0046645)4.24634438
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24011833
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24011833
7positive regulation by symbiont of host defense response (GO:0052509)4.17943163
8modulation by symbiont of host defense response (GO:0052031)4.17943163
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17943163
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17943163
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.17943163
12modulation by symbiont of host immune response (GO:0052553)4.17943163
13Arp2/3 complex-mediated actin nucleation (GO:0034314)4.17399550
14antigen processing and presentation of endogenous antigen (GO:0019883)4.05733153
15leukocyte aggregation (GO:0070486)3.91895844
16detection of other organism (GO:0098543)3.73916810
17membrane raft organization (GO:0031579)3.72402935
18regulation of interferon-beta biosynthetic process (GO:0045357)3.71108088
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62900032
20negative regulation of phagocytosis (GO:0050765)3.54408777
21protein localization to endosome (GO:0036010)3.53110957
22detection of bacterium (GO:0016045)3.50554255
23cellular extravasation (GO:0045123)3.50368282
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46250485
25detection of molecule of bacterial origin (GO:0032490)3.44454312
26positive regulation of lamellipodium assembly (GO:0010592)3.40651481
27regulation of gamma-delta T cell differentiation (GO:0045586)3.37521791
28detection of external biotic stimulus (GO:0098581)3.37221497
29antigen processing and presentation via MHC class Ib (GO:0002475)3.34438932
30positive thymic T cell selection (GO:0045059)3.32482247
31macrophage activation involved in immune response (GO:0002281)3.32217578
32regulation of mast cell degranulation (GO:0043304)3.32114127
33negative thymic T cell selection (GO:0045060)3.26703391
34neutrophil activation involved in immune response (GO:0002283)3.25333087
35B cell receptor signaling pathway (GO:0050853)3.25110432
36positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17160189
37cortical actin cytoskeleton organization (GO:0030866)3.13971484
38negative T cell selection (GO:0043383)3.13940384
39actin nucleation (GO:0045010)3.13276190
40regulation of gamma-delta T cell activation (GO:0046643)3.10609999
41tolerance induction (GO:0002507)3.06185449
42hepatocyte apoptotic process (GO:0097284)3.06180688
43germ cell migration (GO:0008354)3.05432377
44regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03844305
45negative regulation of erythrocyte differentiation (GO:0045647)3.02944823
46thymic T cell selection (GO:0045061)3.02671880
47neutrophil mediated immunity (GO:0002446)2.99741521
48regulation of mast cell activation involved in immune response (GO:0033006)2.99726390
49leukocyte cell-cell adhesion (GO:0007159)2.98808513
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96167721
51response to host immune response (GO:0052572)2.96167721
52detection of biotic stimulus (GO:0009595)2.95370568
53B cell mediated immunity (GO:0019724)2.95090517
54positive regulation of lamellipodium organization (GO:1902745)2.93252374
55neutrophil activation (GO:0042119)2.92543210
56response to peptidoglycan (GO:0032494)2.92449223
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92050138
58response to host defenses (GO:0052200)2.91524299
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91524299
60response to host (GO:0075136)2.91524299
61immunoglobulin mediated immune response (GO:0016064)2.89963849
62mannose metabolic process (GO:0006013)2.87537737
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87060164
64response to laminar fluid shear stress (GO:0034616)2.85373365
65JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84916349
66cell adhesion mediated by integrin (GO:0033627)2.81699790
67granulocyte activation (GO:0036230)2.80851806
68response to fungus (GO:0009620)2.80738575
69positive regulation of histone deacetylation (GO:0031065)2.79267340
70apoptotic cell clearance (GO:0043277)2.78602181
71positive regulation of interferon-alpha production (GO:0032727)2.78425121
72stress fiber assembly (GO:0043149)2.77587431
73Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.77169201
74respiratory burst (GO:0045730)2.76979295
75leukocyte degranulation (GO:0043299)2.76774293
76hypotonic response (GO:0006971)2.74875413
77Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.73909663
78immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.73909663
79Fc-gamma receptor signaling pathway (GO:0038094)2.73909663
80dendritic cell migration (GO:0036336)2.72757057
81type I interferon signaling pathway (GO:0060337)2.72252646
82cellular response to type I interferon (GO:0071357)2.72252646
83regulation of interferon-alpha production (GO:0032647)2.72211409
84regulation of interleukin-12 biosynthetic process (GO:0045075)2.72067561
85negative regulation of lymphocyte mediated immunity (GO:0002707)2.70603909
86regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.70192726
87negative regulation of interleukin-17 production (GO:0032700)2.69986403
88cortical cytoskeleton organization (GO:0030865)2.69714317
89T cell migration (GO:0072678)2.69322524
90negative regulation of interleukin-12 production (GO:0032695)2.68675071
91T cell selection (GO:0045058)2.68419295
92regulation of mast cell activation (GO:0033003)2.67823221
93negative regulation of leukocyte mediated immunity (GO:0002704)2.67808334
94response to type I interferon (GO:0034340)2.67751348
95barbed-end actin filament capping (GO:0051016)2.66044066
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.65723760
97positive regulation of mast cell degranulation (GO:0043306)2.65723760
98regulation of B cell differentiation (GO:0045577)2.65520080
99myeloid cell activation involved in immune response (GO:0002275)2.65261514
100germinal center formation (GO:0002467)2.64503527
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63218406
102leukocyte migration involved in inflammatory response (GO:0002523)2.62561448
103negative regulation of T cell mediated immunity (GO:0002710)2.62553287
104positive regulation of leukocyte degranulation (GO:0043302)2.61851005
105NIK/NF-kappaB signaling (GO:0038061)2.61753679
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60956839
107regulation of T cell tolerance induction (GO:0002664)2.60899326
108receptor catabolic process (GO:0032801)2.60885262
109dendritic cell chemotaxis (GO:0002407)2.59741947
110regulation of early endosome to late endosome transport (GO:2000641)2.59227774
111endodermal cell differentiation (GO:0035987)2.59193885
112regulation of protein heterodimerization activity (GO:0043497)2.56139825
113positive T cell selection (GO:0043368)2.55797435
114platelet aggregation (GO:0070527)2.55660402
115regulation of leukocyte degranulation (GO:0043300)2.55588124
116positive regulation of B cell differentiation (GO:0045579)2.55015019
117substrate-dependent cell migration (GO:0006929)2.53979245
118T cell costimulation (GO:0031295)2.52630281
119positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.52531521
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.51909282
121response to muramyl dipeptide (GO:0032495)2.50718305
122positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.50643917
123positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50280578
124integrin-mediated signaling pathway (GO:0007229)2.50006864
125pinocytosis (GO:0006907)2.49267985
126myeloid leukocyte mediated immunity (GO:0002444)2.49210496
127regulation of tolerance induction (GO:0002643)2.48893720
128natural killer cell differentiation (GO:0001779)2.46432057
129defense response to fungus (GO:0050832)2.46360450
130lymphocyte costimulation (GO:0031294)2.46027659
131response to interleukin-15 (GO:0070672)2.44915337
132negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.44497886
133macrophage differentiation (GO:0030225)2.41839808
134interferon-gamma-mediated signaling pathway (GO:0060333)2.39671024
135positive regulation of macrophage differentiation (GO:0045651)2.38437330
136positive regulation of mast cell activation (GO:0033005)2.36912956
137immune response-activating cell surface receptor signaling pathway (GO:0002429)2.36749213
138positive regulation of tolerance induction (GO:0002645)2.36634128
139regulation of macrophage cytokine production (GO:0010935)2.35566208
140establishment of endothelial barrier (GO:0061028)2.35564554
141negative regulation of granulocyte differentiation (GO:0030853)2.35308999
142neutrophil chemotaxis (GO:0030593)2.35073500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.15868984
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.05772048
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64637685
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.57686334
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.42673360
6MYC_22102868_ChIP-Seq_BL_Human3.27354924
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.95143354
8* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91070927
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89402318
10VDR_21846776_ChIP-Seq_THP-1_Human2.83661381
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76499480
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.75284699
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70329961
14TCF7_22412390_ChIP-Seq_EML_Mouse2.38123583
15* MAF_26560356_Chip-Seq_TH1_Human2.37659679
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.36907213
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.35347220
18* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34394096
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28376167
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26104007
21* KDM2B_26808549_Chip-Seq_DND41_Human2.25250836
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.19590570
23* UTX_26944678_Chip-Seq_JUKART_Human2.16839944
24VDR_24763502_ChIP-Seq_THP-1_Human2.14045085
25* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13869286
26* MYB_26560356_Chip-Seq_TH2_Human2.13553175
27SPI1_23127762_ChIP-Seq_K562_Human2.11874459
28* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08080135
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04517290
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98807922
31RUNX_20019798_ChIP-Seq_JUKART_Human1.96426872
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.91087970
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.87699138
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87645381
35E2F7_22180533_ChIP-Seq_HELA_Human1.85335410
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84427037
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83456547
38* MYB_26560356_Chip-Seq_TH1_Human1.80163280
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.79746459
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78472073
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74521792
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74209884
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74131858
44* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73610122
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72763397
46SPI1_23547873_ChIP-Seq_NB4_Human1.70149171
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.61797213
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60359139
49LXR_22292898_ChIP-Seq_THP-1_Human1.60047396
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59966574
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58054316
52* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56120151
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55488239
54* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54631070
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53980024
56* KDM2B_26808549_Chip-Seq_JURKAT_Human1.52653850
57SCL_19346495_ChIP-Seq_HPC-7_Human1.45523010
58PU_27001747_Chip-Seq_BMDM_Mouse1.45011368
59CLOCK_20551151_ChIP-Seq_293T_Human1.44908643
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42917540
61* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39776647
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38916933
63* MAF_26560356_Chip-Seq_TH2_Human1.37925368
64* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35484721
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35143037
66GATA3_27048872_Chip-Seq_THYMUS_Human1.34607469
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.32838987
68TFEB_21752829_ChIP-Seq_HELA_Human1.31098294
69* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30788356
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28912463
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26876304
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25468378
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24708843
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24109726
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23743757
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.21589042
77* NCOR1_26117541_ChIP-Seq_K562_Human1.21523303
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19492579
79ATF3_27146783_Chip-Seq_COLON_Human1.19460929
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16561185
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16489280
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.12781181
83KDM2B_26808549_Chip-Seq_K562_Human1.11252049
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09928723
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09868850
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09086164
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07253603
88* VDR_24787735_ChIP-Seq_THP-1_Human1.06817113
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06750963
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05601962
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05080058
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02895707
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02847685
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02444931
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02338678
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02293577
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02048827
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01073478
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00994387
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00323102
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99595754
102TP53_22127205_ChIP-Seq_IMR90_Human0.99386682
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98026302
104* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98022638
105* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98022638
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.97722567
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97243874
108GATA3_26560356_Chip-Seq_TH2_Human0.97066881
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96411810
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95413769
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95269624
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93918059
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92493803
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.90977936
115* GATA2_19941826_ChIP-Seq_K562_Human0.90976361
116* GATA1_19941826_ChIP-Seq_K562_Human0.90390212
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.90275352
118PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87996235
119EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87657443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.87563880
2MP0003300_gastrointestinal_ulcer3.57834388
3MP0003436_decreased_susceptibility_to3.23253594
4MP0003705_abnormal_hypodermis_morpholog2.59144523
5MP0001835_abnormal_antigen_presentation2.53052630
6MP0003566_abnormal_cell_adhesion2.47726408
7MP0005058_abnormal_lysosome_morphology2.45456825
8MP0010352_gastrointestinal_tract_polyps2.41074824
9MP0009278_abnormal_bone_marrow2.31689219
10MP0005000_abnormal_immune_tolerance2.29080604
11MP0002419_abnormal_innate_immunity2.20155730
12MP0000685_abnormal_immune_system2.16870044
13MP0001800_abnormal_humoral_immune2.13976462
14MP0005076_abnormal_cell_differentiation2.12644308
15MP0002452_abnormal_antigen_presenting2.08829839
16MP0005464_abnormal_platelet_physiology2.05165498
17MP0001790_abnormal_immune_system2.05071141
18MP0005387_immune_system_phenotype2.05071141
19MP0010234_abnormal_vibrissa_follicle2.03164977
20MP0002166_altered_tumor_susceptibility2.02673550
21MP0005451_abnormal_body_composition1.98011424
22MP0006082_CNS_inflammation1.95852453
23MP0008438_abnormal_cutaneous_collagen1.94273956
24MP0002420_abnormal_adaptive_immunity1.93923401
25MP0001819_abnormal_immune_cell1.93031771
26MP0005671_abnormal_response_to1.92343067
27MP0004510_myositis1.92123576
28MP0001533_abnormal_skeleton_physiology1.88327965
29MP0003172_abnormal_lysosome_physiology1.87292439
30MP0004947_skin_inflammation1.86495310
31MP0005025_abnormal_response_to1.86193464
32MP0002723_abnormal_immune_serum1.85787460
33MP0003448_altered_tumor_morphology1.82366932
34MP0005023_abnormal_wound_healing1.79377502
35MP0003091_abnormal_cell_migration1.77787727
36MP0000858_altered_metastatic_potential1.77099432
37MP0009785_altered_susceptibility_to1.76658094
38MP0010307_abnormal_tumor_latency1.69142692
39MP0002405_respiratory_system_inflammati1.67970761
40MP0002398_abnormal_bone_marrow1.66741817
41MP0004808_abnormal_hematopoietic_stem1.61739303
42MP0009333_abnormal_splenocyte_physiolog1.61301103
43MP0002006_tumorigenesis1.58226916
44MP0010155_abnormal_intestine_physiology1.57542969
45MP0000465_gastrointestinal_hemorrhage1.55151378
46MP0005397_hematopoietic_system_phenotyp1.54119893
47MP0001545_abnormal_hematopoietic_system1.54119893
48MP0000716_abnormal_immune_system1.52915521
49MP0002148_abnormal_hypersensitivity_rea1.49358920
50MP0003763_abnormal_thymus_physiology1.47156448
51MP0001845_abnormal_inflammatory_respons1.43353020
52MP0003075_altered_response_to1.42606298
53MP0002933_joint_inflammation1.41717230
54MP0000689_abnormal_spleen_morphology1.41565395
55MP0002722_abnormal_immune_system1.39618971
56MP0000569_abnormal_digit_pigmentation1.38739939
57MP0001542_abnormal_bone_strength1.33809725
58MP0001958_emphysema1.33553277
59MP0003279_aneurysm1.33104454
60MP0001853_heart_inflammation1.31438087
61MP0008004_abnormal_stomach_pH1.30753443
62MP0000343_altered_response_to1.30419958
63MP0002877_abnormal_melanocyte_morpholog1.26442173
64MP0002429_abnormal_blood_cell1.25865385
65MP0003453_abnormal_keratinocyte_physiol1.24496404
66MP0001873_stomach_inflammation1.23425734
67MP0006054_spinal_hemorrhage1.20310122
68MP0000604_amyloidosis1.19551472
69MP0000015_abnormal_ear_pigmentation1.17989817
70MP0002998_abnormal_bone_remodeling1.16763489
71MP0003045_fibrosis1.16449354
72MP0003724_increased_susceptibility_to1.15184007
73MP0002396_abnormal_hematopoietic_system1.15143280
74MP0003183_abnormal_peptide_metabolism1.14756571
75MP0000703_abnormal_thymus_morphology1.13604757
76MP0005310_abnormal_salivary_gland1.12827228
77MP0005166_decreased_susceptibility_to1.12463588
78MP0003866_abnormal_defecation1.11554179
79MP0000490_abnormal_crypts_of1.09005517
80MP0001851_eye_inflammation1.08350850
81MP0003191_abnormal_cellular_cholesterol1.06747401
82MP0005164_abnormal_response_to1.05263221
83MP0009764_decreased_sensitivity_to1.03944647
84MP0009840_abnormal_foam_cell1.00263386
85MP0005167_abnormal_blood-brain_barrier0.99639995
86MP0000733_abnormal_muscle_development0.99465122
87MP0001849_ear_inflammation0.98823693
88MP0005275_abnormal_skin_tensile0.95420866
89MP0002132_abnormal_respiratory_system0.94501241
90MP0005390_skeleton_phenotype0.93927527
91MP0004381_abnormal_hair_follicle0.93888551
92MP0004185_abnormal_adipocyte_glucose0.91636750
93MP0003806_abnormal_nucleotide_metabolis0.91004886
94MP0003656_abnormal_erythrocyte_physiolo0.90389194
95MP0008469_abnormal_protein_level0.89021418
96MP0009763_increased_sensitivity_to0.84681795
97MP0003828_pulmonary_edema0.81767527
98MP0008961_abnormal_basal_metabolism0.81147539
99MP0005623_abnormal_meninges_morphology0.81025300
100MP0005257_abnormal_intraocular_pressure0.80902527
101MP0000249_abnormal_blood_vessel0.76610767
102MP0003795_abnormal_bone_structure0.74995956
103MP0002019_abnormal_tumor_incidence0.73264693
104MP0001915_intracranial_hemorrhage0.72106926
105MP0005165_increased_susceptibility_to0.70825470
106MP0005174_abnormal_tail_pigmentation0.70176647
107MP0001216_abnormal_epidermal_layer0.67932047
108MP0005621_abnormal_cell_physiology0.67709410
109MP0002060_abnormal_skin_morphology0.65908765
110MP0000767_abnormal_smooth_muscle0.65717155
111MP0001663_abnormal_digestive_system0.64878264
112MP0004883_abnormal_blood_vessel0.64785540
113MP0000477_abnormal_intestine_morphology0.63315543
114MP0008260_abnormal_autophagy0.61361528

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.40956021
2Recurrent abscess formation (HP:0002722)4.05434152
3Increased cerebral lipofuscin (HP:0011813)3.57161910
4Recurrent bacterial skin infections (HP:0005406)3.30785151
5Cerebral aneurysm (HP:0004944)3.29971732
6Cellulitis (HP:0100658)3.20368339
7Petechiae (HP:0000967)2.97071750
8Increased density of long bones (HP:0006392)2.96457363
9Abnormality of macrophages (HP:0004311)2.92548783
10Recurrent fungal infections (HP:0002841)2.91264547
11Recurrent gram-negative bacterial infections (HP:0005420)2.88966052
12Dysostosis multiplex (HP:0000943)2.84599755
13Mediastinal lymphadenopathy (HP:0100721)2.77051516
14Hematochezia (HP:0002573)2.76794292
15Increased neuronal autofluorescent lipopigment (HP:0002074)2.75587216
16Obstructive lung disease (HP:0006536)2.72790809
17Chronic obstructive pulmonary disease (HP:0006510)2.72790809
18Retrobulbar optic neuritis (HP:0100654)2.71572664
19Optic neuritis (HP:0100653)2.71572664
20Abnormal platelet volume (HP:0011876)2.68253766
21Epistaxis (HP:0000421)2.66329699
22Prolonged bleeding time (HP:0003010)2.65145992
23Gingival bleeding (HP:0000225)2.63093542
24Dilatation of the ascending aorta (HP:0005111)2.62318479
25Myositis (HP:0100614)2.60345010
26Protrusio acetabuli (HP:0003179)2.59834663
27Vacuolated lymphocytes (HP:0001922)2.58065511
28Urticaria (HP:0001025)2.57469280
29Recurrent viral infections (HP:0004429)2.54824129
30Gastrointestinal infarctions (HP:0005244)2.54791772
31Interstitial pulmonary disease (HP:0006530)2.54079217
32Hepatosplenomegaly (HP:0001433)2.53935581
33Aortic aneurysm (HP:0004942)2.51516510
34Verrucae (HP:0200043)2.51455247
35Papilloma (HP:0012740)2.51455247
36Osteolytic defects of the hand bones (HP:0009699)2.51435721
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.51435721
38Stomatitis (HP:0010280)2.46881307
39Increased mean platelet volume (HP:0011877)2.46375303
40Premature rupture of membranes (HP:0001788)2.45615113
41Peritonitis (HP:0002586)2.44025905
42Myocardial infarction (HP:0001658)2.43907903
43Amyloidosis (HP:0011034)2.43810002
44Ankle contracture (HP:0006466)2.42865490
45Urinary glycosaminoglycan excretion (HP:0003541)2.39196600
46Mucopolysacchariduria (HP:0008155)2.39196600
47Aortic dissection (HP:0002647)2.38904343
48Elevated erythrocyte sedimentation rate (HP:0003565)2.36737541
49Disinhibition (HP:0000734)2.35941106
50Mitral valve prolapse (HP:0001634)2.34627652
51Chronic otitis media (HP:0000389)2.32995270
52Leukocytosis (HP:0001974)2.31109120
53Spontaneous hematomas (HP:0007420)2.29440758
54Meningitis (HP:0001287)2.26284869
55Purpura (HP:0000979)2.25661119
56Encephalitis (HP:0002383)2.25462886
57Cervical subluxation (HP:0003308)2.24434100
58Gingivitis (HP:0000230)2.23724195
59Recurrent skin infections (HP:0001581)2.23562894
60Short nail (HP:0001799)2.22738803
61Autoimmune thrombocytopenia (HP:0001973)2.21301121
62Increased IgE level (HP:0003212)2.18792332
63Pulmonary infiltrates (HP:0002113)2.18641601
64Amaurosis fugax (HP:0100576)2.17585499
65Pustule (HP:0200039)2.17415921
66Granulocytopenia (HP:0001913)2.17204032
67Shallow orbits (HP:0000586)2.14868514
68Abnormality of liposaccharide metabolism (HP:0010968)2.14149871
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.14149871
70Abnormality of glycolipid metabolism (HP:0010969)2.14149871
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13975664
72Abnormality of polysaccharide metabolism (HP:0011012)2.13975664
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13975664
74Genu recurvatum (HP:0002816)2.13248546
75Keratoconjunctivitis sicca (HP:0001097)2.12349373
76Abnormality of T cells (HP:0002843)2.11954293
77Abnormality of the distal phalanges of the toes (HP:0010182)2.10899485
78Papilledema (HP:0001085)2.09930426
79Inflammation of the large intestine (HP:0002037)2.09296335
80Hemoptysis (HP:0002105)2.09293003
81Gastrointestinal inflammation (HP:0004386)2.07823390
82Striae distensae (HP:0001065)2.06723632
83Persistence of primary teeth (HP:0006335)2.06569469
84Nasal polyposis (HP:0100582)2.05525834
85Thick nail (HP:0001805)2.05050379
86Arterial thrombosis (HP:0004420)2.04863761
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03470300
88Osteomyelitis (HP:0002754)2.03186371
89Upper motor neuron abnormality (HP:0002127)2.03128124
90Orchitis (HP:0100796)2.02659774
91Skin ulcer (HP:0200042)2.01651488
92Entropion (HP:0000621)2.01055651
93Reduced subcutaneous adipose tissue (HP:0003758)2.00025614
94Recurrent cutaneous fungal infections (HP:0011370)1.99951291
95Chronic mucocutaneous candidiasis (HP:0002728)1.99951291
96Hypergammaglobulinemia (HP:0010702)1.99802009
97Premature loss of primary teeth (HP:0006323)1.99748365
98Diminished motivation (HP:0000745)1.99520363
99Periodontitis (HP:0000704)1.99314120
100Vertebral compression fractures (HP:0002953)1.98986883
101Ulnar bowing (HP:0003031)1.97479810
102Systemic lupus erythematosus (HP:0002725)1.97186948
103Loss of speech (HP:0002371)1.96655202
104Increased IgM level (HP:0003496)1.96392886
105Abnormality of the nasal mucosa (HP:0000433)1.95976932
106Thrombocytosis (HP:0001894)1.95657071
107Colitis (HP:0002583)1.94216941
108Apathy (HP:0000741)1.93970643
109Abnormal platelet function (HP:0011869)1.92904004
110Impaired platelet aggregation (HP:0003540)1.92904004
111Fatigue (HP:0012378)1.91201137
112Glomerulopathy (HP:0100820)1.90316766
113Abnormality of oral frenula (HP:0000190)1.89195872
114Polycythemia (HP:0001901)1.88787006
115Chest pain (HP:0100749)1.88445999
116Upper limb amyotrophy (HP:0009129)1.88333839
117Distal upper limb amyotrophy (HP:0007149)1.88333839
118Hyperacusis (HP:0010780)1.86995325
119Abnormality of T cell physiology (HP:0011840)1.86165536
120Recurrent bronchitis (HP:0002837)1.86151782
121Spondylolisthesis (HP:0003302)1.85785394
122Keratoconjunctivitis (HP:0001096)1.85698891
123Abnormality of the peritoneum (HP:0002585)1.85674403
124Thoracic kyphosis (HP:0002942)1.85511577
125Absent frontal sinuses (HP:0002688)1.84747999
126Axonal loss (HP:0003447)1.84656166
127Subacute progressive viral hepatitis (HP:0006572)1.84599562
128IgM deficiency (HP:0002850)1.83186948
129T lymphocytopenia (HP:0005403)1.82831287
130Autoimmune hemolytic anemia (HP:0001890)1.82280201
131Eosinophilia (HP:0001880)1.81692270
132Lymphopenia (HP:0001888)1.79865038
133Increased CSF protein (HP:0002922)1.78314329
134Arterial tortuosity (HP:0005116)1.77838487
135Vasculitis (HP:0002633)1.77686392
136Glucose intolerance (HP:0000833)1.77522858
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.76937568
138Abnormality of T cell number (HP:0011839)1.76292843
139Arthralgia (HP:0002829)1.75551746
140Abnormality of cells of the lymphoid lineage (HP:0012140)1.75495614
141Acrocyanosis (HP:0001063)1.75092528
142Frequent falls (HP:0002359)1.74830857
143Atrophic scars (HP:0001075)1.74298598
144Bicuspid aortic valve (HP:0001647)1.74135653
145Rough bone trabeculation (HP:0100670)1.74008322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.85582615
2MAP4K13.09620418
3PKN22.95014358
4STK102.43758871
5EEF2K2.42870711
6ERN12.37177416
7GRK62.35513658
8PRPF4B2.29553729
9TESK22.28054308
10LRRK22.19937079
11TTN2.12028259
12MAP3K102.10771376
13FES1.99438271
14EPHB11.87806278
15TESK11.79793661
16EIF2AK31.77496016
17RIPK41.77134364
18SIK31.63880913
19TYK21.59890455
20CSK1.55665080
21JAK11.55109229
22KIT1.53748975
23TGFBR21.53453920
24RIPK11.52800054
25HCK1.52703071
26PTK61.52515685
27ITK1.50586956
28BLK1.50058106
29TRPM71.49434997
30KSR21.46096282
31ALK1.44304993
32SCYL21.44246600
33ZAP701.43680477
34IRAK31.32732017
35TBK11.31404335
36PAK41.30889269
37JAK31.29467447
38CDK121.26204719
39BTK1.25853877
40BMX1.20452483
41CSF1R1.20381369
42TAOK11.18855157
43FGFR31.18134355
44NME21.15600570
45PIK3CG1.11001112
46MAP2K31.10633707
47YES11.10284165
48FGFR41.08592294
49CLK11.07338613
50SYK1.06462601
51CAMKK11.05918877
52BMPR21.01977751
53TXK0.99192865
54FGR0.98926981
55SMG10.98054983
56CDK60.96256232
57JAK20.95610646
58TAOK20.92827244
59PRKCH0.91451703
60SIK20.90559637
61PDGFRA0.89264174
62LCK0.88854883
63IRAK40.88299611
64TAOK30.88031115
65MAP3K90.86566397
66RPS6KA40.85918065
67MAP3K80.84713019
68PIM10.84670576
69TEC0.84176594
70DMPK0.83732738
71NLK0.75971351
72PTK20.75651043
73MAP3K20.74207811
74MAP3K120.72288762
75STK240.71539879
76RET0.71363464
77CAMK1D0.71149410
78MAP3K60.69784190
79IKBKE0.69341692
80MYLK0.67701751
81MAP3K50.64009387
82MAP3K130.61470251
83MARK30.60799159
84MAP3K10.59982528
85MAP3K110.59604783
86PAK20.58844985
87MAPK70.58616220
88LYN0.57851745
89LIMK10.57591767
90PRKG20.56389047
91SGK30.56284836
92MAPKAPK20.56263057
93CAMKK20.56234061
94TNK20.55832676
95PDGFRB0.55584471
96MAP3K30.55361665
97MAPK120.54374124
98CDK40.53311826
99NEK20.53066912
100FYN0.52398864
101EGFR0.51049201
102CDC42BPA0.50679025
103PDK10.50567308
104NEK90.48933731
105CAMK1G0.48269882
106MAP3K140.46285648
107DYRK1B0.46280081
108PTK2B0.43383765
109IKBKB0.43320513
110KSR10.43125613
111ILK0.43039199
112PRKD20.43028813
113RPS6KA20.42696296
114ARAF0.42291529
115FRK0.41751782
116DDR20.40392957
117MOS0.39716917
118PRKCQ0.39437975
119MATK0.39409831
120MARK20.39166046
121SRC0.38259709
122PAK10.38238754
123ABL10.38208285
124GRK70.38013858
125KDR0.37144913
126PDPK10.36160181
127RAF10.35873167

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.38116824
2Osteoclast differentiation_Homo sapiens_hsa043802.15018061
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12631845
4B cell receptor signaling pathway_Homo sapiens_hsa046622.09176719
5Leukocyte transendothelial migration_Homo sapiens_hsa046701.90710905
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90650530
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78071432
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74519013
9Shigellosis_Homo sapiens_hsa051311.67089138
10Chronic myeloid leukemia_Homo sapiens_hsa052201.65955842
11Autoimmune thyroid disease_Homo sapiens_hsa053201.64538634
12Tuberculosis_Homo sapiens_hsa051521.58075793
13Antigen processing and presentation_Homo sapiens_hsa046121.58047551
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55291219
15Toxoplasmosis_Homo sapiens_hsa051451.54689006
16Primary immunodeficiency_Homo sapiens_hsa053401.46771560
17Staphylococcus aureus infection_Homo sapiens_hsa051501.46633203
18T cell receptor signaling pathway_Homo sapiens_hsa046601.45281238
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.44926622
20Lysosome_Homo sapiens_hsa041421.44513180
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43529502
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43509861
23Salmonella infection_Homo sapiens_hsa051321.40930872
24Pancreatic cancer_Homo sapiens_hsa052121.38727117
25Pertussis_Homo sapiens_hsa051331.37286317
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36918265
27VEGF signaling pathway_Homo sapiens_hsa043701.33839790
28Measles_Homo sapiens_hsa051621.32998623
29Chemokine signaling pathway_Homo sapiens_hsa040621.31192352
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31177619
31Acute myeloid leukemia_Homo sapiens_hsa052211.31175904
32Platelet activation_Homo sapiens_hsa046111.31168326
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.30933299
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30070154
35Viral myocarditis_Homo sapiens_hsa054161.25005542
36Hepatitis B_Homo sapiens_hsa051611.24844157
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24641318
38Rheumatoid arthritis_Homo sapiens_hsa053231.23943858
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.22760061
40Apoptosis_Homo sapiens_hsa042101.22310162
41Proteoglycans in cancer_Homo sapiens_hsa052051.22285576
42Non-small cell lung cancer_Homo sapiens_hsa052231.22044041
43Amoebiasis_Homo sapiens_hsa051461.18289715
44Glioma_Homo sapiens_hsa052141.16269348
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15413191
46Focal adhesion_Homo sapiens_hsa045101.14351405
47Other glycan degradation_Homo sapiens_hsa005111.12715824
48Type I diabetes mellitus_Homo sapiens_hsa049401.12137860
49TNF signaling pathway_Homo sapiens_hsa046681.09578361
50Endocytosis_Homo sapiens_hsa041441.08828382
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08443280
52Small cell lung cancer_Homo sapiens_hsa052221.08063841
53Colorectal cancer_Homo sapiens_hsa052101.06489542
54Hematopoietic cell lineage_Homo sapiens_hsa046401.04660881
55Malaria_Homo sapiens_hsa051441.03939091
56mTOR signaling pathway_Homo sapiens_hsa041501.03281612
57Adherens junction_Homo sapiens_hsa045201.02083760
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.01232736
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.96140620
60Endometrial cancer_Homo sapiens_hsa052130.95938080
61Legionellosis_Homo sapiens_hsa051340.94943815
62Influenza A_Homo sapiens_hsa051640.93636335
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92562368
64Renal cell carcinoma_Homo sapiens_hsa052110.91926919
65Bladder cancer_Homo sapiens_hsa052190.89711938
66MicroRNAs in cancer_Homo sapiens_hsa052060.88550147
67Phagosome_Homo sapiens_hsa041450.85170597
68HIF-1 signaling pathway_Homo sapiens_hsa040660.84506781
69Viral carcinogenesis_Homo sapiens_hsa052030.80307979
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.79497721
71Prolactin signaling pathway_Homo sapiens_hsa049170.79058319
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78979978
73Epstein-Barr virus infection_Homo sapiens_hsa051690.76157228
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76024344
75Estrogen signaling pathway_Homo sapiens_hsa049150.75023484
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74693499
77Rap1 signaling pathway_Homo sapiens_hsa040150.73581907
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73478360
79African trypanosomiasis_Homo sapiens_hsa051430.73463429
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.73129804
81HTLV-I infection_Homo sapiens_hsa051660.72502626
82Pentose phosphate pathway_Homo sapiens_hsa000300.72327243
83Prostate cancer_Homo sapiens_hsa052150.71876365
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.70951157
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70606012
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69056401
87Hepatitis C_Homo sapiens_hsa051600.68105248
88Thyroid cancer_Homo sapiens_hsa052160.66968955
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66878746
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65519633
91Herpes simplex infection_Homo sapiens_hsa051680.63960408
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62888773
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62246869
94Dorso-ventral axis formation_Homo sapiens_hsa043200.61992536
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60737544
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60540638
97Insulin resistance_Homo sapiens_hsa049310.60025478
98Vibrio cholerae infection_Homo sapiens_hsa051100.59627954
99Graft-versus-host disease_Homo sapiens_hsa053320.59210600
100Galactose metabolism_Homo sapiens_hsa000520.59007915
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58154422
102ECM-receptor interaction_Homo sapiens_hsa045120.57553759
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57144916
104FoxO signaling pathway_Homo sapiens_hsa040680.56871531
105Allograft rejection_Homo sapiens_hsa053300.54935481
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52946344
107MAPK signaling pathway_Homo sapiens_hsa040100.52599395
108Pathways in cancer_Homo sapiens_hsa052000.51478233
109Type II diabetes mellitus_Homo sapiens_hsa049300.50808334
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50765476
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50528093
112Renin-angiotensin system_Homo sapiens_hsa046140.49612137
113Asthma_Homo sapiens_hsa053100.48904007
114Notch signaling pathway_Homo sapiens_hsa043300.48649782
115ErbB signaling pathway_Homo sapiens_hsa040120.47510993
116GnRH signaling pathway_Homo sapiens_hsa049120.47149272
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45349577
118Fatty acid elongation_Homo sapiens_hsa000620.39629293
119Inositol phosphate metabolism_Homo sapiens_hsa005620.35341867

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »