CAP1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.75977723
2negative regulation by host of viral transcription (GO:0043922)5.26472322
3Arp2/3 complex-mediated actin nucleation (GO:0034314)5.02873309
4positive thymic T cell selection (GO:0045059)4.99939369
5pyrimidine nucleoside catabolic process (GO:0046135)4.76836547
6positive T cell selection (GO:0043368)4.66862592
7actin nucleation (GO:0045010)4.65283873
8negative regulation of T cell apoptotic process (GO:0070233)4.50067314
9eosinophil chemotaxis (GO:0048245)4.46652118
10positive regulation of interleukin-8 secretion (GO:2000484)4.45297710
11regulation of lymphocyte chemotaxis (GO:1901623)4.39107040
12cellular response to interleukin-15 (GO:0071350)4.32243571
13negative regulation of calcium ion transport into cytosol (GO:0010523)4.17369502
14positive regulation of calcium-mediated signaling (GO:0050850)4.12233230
15positive regulation of natural killer cell mediated immunity (GO:0002717)4.08208077
16positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.05277543
17eosinophil migration (GO:0072677)4.01611233
18positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.99152768
19regulation of chronic inflammatory response (GO:0002676)3.98748597
20negative regulation of viral genome replication (GO:0045071)3.95839378
21T cell migration (GO:0072678)3.93755017
22negative T cell selection (GO:0043383)3.91824183
23activated T cell proliferation (GO:0050798)3.91308229
24regulation of activation of Janus kinase activity (GO:0010533)3.90831952
25sequestering of actin monomers (GO:0042989)3.89410994
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.77709881
27regulation of T cell chemotaxis (GO:0010819)3.76812146
28positive regulation of T cell chemotaxis (GO:0010820)3.76812146
29cytolysis (GO:0019835)3.75995823
30positive regulation of defense response to virus by host (GO:0002230)3.75911494
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.73300446
32platelet dense granule organization (GO:0060155)3.71303589
33regulation of leukocyte mediated cytotoxicity (GO:0001910)3.66523238
34response to interleukin-15 (GO:0070672)3.66346371
35positive regulation of lymphocyte migration (GO:2000403)3.65032539
36regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.63225227
37regulation of natural killer cell mediated immunity (GO:0002715)3.63225227
38macrophage chemotaxis (GO:0048246)3.62994225
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62705229
40lymphocyte chemotaxis (GO:0048247)3.55256975
41positive regulation of gamma-delta T cell activation (GO:0046645)3.51490337
42thymic T cell selection (GO:0045061)3.48044761
43positive regulation of cell killing (GO:0031343)3.42685256
44positive regulation of translational initiation (GO:0045948)3.40092060
45regulation of T cell mediated cytotoxicity (GO:0001914)3.40048579
46negative regulation of viral transcription (GO:0032897)3.38534125
47regulation of interleukin-8 secretion (GO:2000482)3.35543502
48regulation of regulatory T cell differentiation (GO:0045589)3.35376892
49negative regulation of lymphocyte apoptotic process (GO:0070229)3.34854874
50regulation of T cell receptor signaling pathway (GO:0050856)3.24526429
51regulation of B cell receptor signaling pathway (GO:0050855)3.21643256
52regulation of cell killing (GO:0031341)3.21061923
53positive regulation of prostaglandin secretion (GO:0032308)3.17891071
54negative thymic T cell selection (GO:0045060)3.17214321
55regulation of T cell tolerance induction (GO:0002664)3.13853310
56regulation of T cell apoptotic process (GO:0070232)3.10806368
57negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.08492873
58positive regulation of T cell apoptotic process (GO:0070234)3.08228873
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.05021961
60cellular defense response (GO:0006968)3.04116987
61T cell selection (GO:0045058)3.03160023
62regulation of gamma-delta T cell differentiation (GO:0045586)3.00946857
63pyrimidine ribonucleoside metabolic process (GO:0046131)3.00343771
64regulation of calcium-mediated signaling (GO:0050848)3.00070670
65pyrimidine-containing compound catabolic process (GO:0072529)2.94542303
66positive regulation of tolerance induction (GO:0002645)2.93962314
67modulation by host of symbiont transcription (GO:0052472)2.93656726
68modulation by host of viral transcription (GO:0043921)2.93656726
69regulation of isotype switching to IgG isotypes (GO:0048302)2.93453036
70lymphocyte migration (GO:0072676)2.92153703
71regulation of cellular amino acid metabolic process (GO:0006521)2.89157284
72regulation of viral genome replication (GO:0045069)2.88676867
73nucleoside diphosphate catabolic process (GO:0009134)2.87986074
74T cell receptor signaling pathway (GO:0050852)2.87713304
75response to interferon-beta (GO:0035456)2.87112011
76positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86867329
77proteasome assembly (GO:0043248)2.85969677
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84182552
79iron-sulfur cluster assembly (GO:0016226)2.82848677
80metallo-sulfur cluster assembly (GO:0031163)2.82848677
81natural killer cell activation (GO:0030101)2.81317430
82modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.80755900
83regulation of alpha-beta T cell proliferation (GO:0046640)2.77011514
84regulation of lymphocyte migration (GO:2000401)2.76169319
85establishment of protein localization to mitochondrial membrane (GO:0090151)2.75992976
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73411381
87behavioral response to nicotine (GO:0035095)2.69961065
88L-fucose catabolic process (GO:0042355)2.69312644
89fucose catabolic process (GO:0019317)2.69312644
90L-fucose metabolic process (GO:0042354)2.69312644
91negative regulation of viral process (GO:0048525)2.69223891
92negative regulation of T cell receptor signaling pathway (GO:0050860)2.68051126
93positive regulation of lamellipodium assembly (GO:0010592)2.65561115
94positive regulation of T cell migration (GO:2000406)2.64420037
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62686988
96cytidine deamination (GO:0009972)10.8918354
97cytidine metabolic process (GO:0046087)10.8918354
98cytidine catabolic process (GO:0006216)10.8918354
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.3809436
100DNA deamination (GO:0045006)10.0756548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.90347828
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.58478490
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26060266
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.03440367
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.85023609
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74661003
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71327933
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.54942170
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25657732
10VDR_22108803_ChIP-Seq_LS180_Human3.20409806
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.95206946
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77952526
13MYB_26560356_Chip-Seq_TH2_Human2.49183939
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.42007167
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28071438
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23401346
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22993274
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.22047489
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.11082823
20RUNX_20019798_ChIP-Seq_JUKART_Human2.05622410
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98131682
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81702378
23GATA3_27048872_Chip-Seq_THYMUS_Human1.78963555
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78295773
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76262008
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72630354
27GATA3_26560356_Chip-Seq_TH2_Human1.71745001
28VDR_23849224_ChIP-Seq_CD4+_Human1.70166423
29MYB_26560356_Chip-Seq_TH1_Human1.68519209
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.64794540
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50809850
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48847578
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.47007263
34UTX_26944678_Chip-Seq_JUKART_Human1.42096609
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.41202788
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41145984
37TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.39495060
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35257441
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33332646
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.31621665
41FOXP3_21729870_ChIP-Seq_TREG_Human1.30448273
42TP53_22573176_ChIP-Seq_HFKS_Human1.29181378
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28729964
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27329067
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24726763
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24380027
47MAF_26560356_Chip-Seq_TH1_Human1.24003616
48IGF1R_20145208_ChIP-Seq_DFB_Human1.22880810
49ELK1_19687146_ChIP-ChIP_HELA_Human1.21892396
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20629009
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19988969
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17729945
53MAF_26560356_Chip-Seq_TH2_Human1.14587559
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14521822
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14336305
56ZNF274_21170338_ChIP-Seq_K562_Hela1.14218982
57MYC_18940864_ChIP-ChIP_HL60_Human1.13811019
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13265933
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12521258
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11939979
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.11685940
62SPI1_23547873_ChIP-Seq_NB4_Human1.11605869
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09551565
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.09242653
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07498090
66TAF2_19829295_ChIP-Seq_ESCs_Human1.06780015
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.03612648
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03612648
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.03527411
70FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02624304
71BCL6_27268052_Chip-Seq_Bcells_Human1.02470055
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01408357
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00388839
74NANOG_20526341_ChIP-Seq_ESCs_Human1.00115272
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99905181
76NCOR_22424771_ChIP-Seq_293T_Human0.98451377
77AR_20517297_ChIP-Seq_VCAP_Human0.96389484
78SOX2_19829295_ChIP-Seq_ESCs_Human0.95941401
79NANOG_19829295_ChIP-Seq_ESCs_Human0.95941401
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95863602
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.94496236
82P300_27268052_Chip-Seq_Bcells_Human0.92909489
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92168871
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86749340
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86642788
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85799735
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85737046
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.85021069
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84098679
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83676353
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83421630
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82678380
93ERA_21632823_ChIP-Seq_H3396_Human0.79816645
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.78565157
95HOXB7_26014856_ChIP-Seq_BT474_Human0.78324244
96HTT_18923047_ChIP-ChIP_STHdh_Human0.78028357
97IRF1_19129219_ChIP-ChIP_H3396_Human0.76817152
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76280321
99ERG_20517297_ChIP-Seq_VCAP_Human0.76201318
100GATA3_26560356_Chip-Seq_TH1_Human0.75623865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.81284878
2MP0003763_abnormal_thymus_physiology3.56237244
3MP0002102_abnormal_ear_morphology3.01706919
4MP0009785_altered_susceptibility_to2.97310017
5MP0001835_abnormal_antigen_presentation2.96200598
6MP0009333_abnormal_splenocyte_physiolog2.93138183
7MP0002148_abnormal_hypersensitivity_rea2.86258932
8MP0005000_abnormal_immune_tolerance2.69044162
9MP0005377_hearing/vestibular/ear_phenot2.58123165
10MP0003878_abnormal_ear_physiology2.58123165
11MP0006072_abnormal_retinal_apoptosis2.56073806
12MP0002166_altered_tumor_susceptibility2.52193461
13MP0002723_abnormal_immune_serum2.42259512
14MP0001800_abnormal_humoral_immune2.35951467
15MP0002420_abnormal_adaptive_immunity2.33260352
16MP0003866_abnormal_defecation2.28343573
17MP0001819_abnormal_immune_cell2.28237332
18MP0000685_abnormal_immune_system2.26423356
19MP0005025_abnormal_response_to2.17898567
20MP0006082_CNS_inflammation2.14503507
21MP0003045_fibrosis2.10962384
22MP0005464_abnormal_platelet_physiology2.01367978
23MP0002452_abnormal_antigen_presenting1.99577663
24MP0001790_abnormal_immune_system1.98254111
25MP0005387_immune_system_phenotype1.98254111
26MP0002006_tumorigenesis1.97599993
27MP0001501_abnormal_sleep_pattern1.95875595
28MP0003786_premature_aging1.85193010
29MP0002398_abnormal_bone_marrow1.82353870
30MP0000716_abnormal_immune_system1.73924578
31MP0005645_abnormal_hypothalamus_physiol1.72387114
32MP0003436_decreased_susceptibility_to1.59333254
33MP0001485_abnormal_pinna_reflex1.59235138
34MP0000703_abnormal_thymus_morphology1.56502102
35MP0004145_abnormal_muscle_electrophysio1.56423383
36MP0002419_abnormal_innate_immunity1.51818714
37MP0002722_abnormal_immune_system1.51608740
38MP0010155_abnormal_intestine_physiology1.49931237
39MP0000689_abnormal_spleen_morphology1.44539201
40MP0003195_calcinosis1.43961818
41MP0002405_respiratory_system_inflammati1.35853575
42MP0002429_abnormal_blood_cell1.34834241
43MP0001845_abnormal_inflammatory_respons1.34056065
44MP0001968_abnormal_touch/_nociception1.32874754
45MP0002138_abnormal_hepatobiliary_system1.30282059
46MP0002909_abnormal_adrenal_gland1.28829803
47MP0001986_abnormal_taste_sensitivity1.26792903
48MP0001905_abnormal_dopamine_level1.26408807
49MP0002736_abnormal_nociception_after1.25349601
50MP0004885_abnormal_endolymph1.23610195
51MP0002933_joint_inflammation1.21942517
52MP0003448_altered_tumor_morphology1.20701462
53MP0004147_increased_porphyrin_level1.19168031
54MP0008469_abnormal_protein_level1.18498938
55MP0001502_abnormal_circadian_rhythm1.16486693
56MP0005075_abnormal_melanosome_morpholog1.15364114
57MP0005253_abnormal_eye_physiology1.13678010
58MP0001919_abnormal_reproductive_system1.13606841
59MP0009764_decreased_sensitivity_to1.12974934
60MP0005379_endocrine/exocrine_gland_phen1.12241152
61MP0000372_irregular_coat_pigmentation1.08372233
62MP0006276_abnormal_autonomic_nervous1.07490732
63MP0002876_abnormal_thyroid_physiology1.06444371
64MP0005551_abnormal_eye_electrophysiolog1.05839046
65MP0008872_abnormal_physiological_respon1.04539771
66MP0009763_increased_sensitivity_to1.03232629
67MP0004947_skin_inflammation1.02457699
68MP0003724_increased_susceptibility_to1.02404837
69MP0008877_abnormal_DNA_methylation1.00830218
70MP0003011_delayed_dark_adaptation1.00580335
71MP0001853_heart_inflammation0.95132427
72MP0001661_extended_life_span0.93989999
73MP0001533_abnormal_skeleton_physiology0.92543989
74MP0008875_abnormal_xenobiotic_pharmacok0.91363535
75MP0001348_abnormal_lacrimal_gland0.86412814
76MP0002877_abnormal_melanocyte_morpholog0.86094586
77MP0005165_increased_susceptibility_to0.85789648
78MP0002733_abnormal_thermal_nociception0.83587117
79MP0000858_altered_metastatic_potential0.81023636
80MP0005389_reproductive_system_phenotype0.78660388
81MP0001765_abnormal_ion_homeostasis0.77420431
82MP0001542_abnormal_bone_strength0.77221582
83MP0005360_urolithiasis0.76355206
84MP0009745_abnormal_behavioral_response0.74730100
85MP0005166_decreased_susceptibility_to0.74207409
86MP0010386_abnormal_urinary_bladder0.72893042
87MP0005410_abnormal_fertilization0.72815223
88MP0002095_abnormal_skin_pigmentation0.72233736
89MP0002163_abnormal_gland_morphology0.70827319
90MP0001873_stomach_inflammation0.67173513
91MP0008007_abnormal_cellular_replicative0.66084407
92MP0000465_gastrointestinal_hemorrhage0.63885788
93MP0001970_abnormal_pain_threshold0.63158585
94MP0002019_abnormal_tumor_incidence0.62207382
95MP0001486_abnormal_startle_reflex0.62204917
96MP0002693_abnormal_pancreas_physiology0.61864282
97MP0006036_abnormal_mitochondrial_physio0.60976198
98MP0003137_abnormal_impulse_conducting0.58210126
99MP0005084_abnormal_gallbladder_morpholo0.57064867
100MP0004142_abnormal_muscle_tone0.56663615

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.65069626
2Abnormality of T cell number (HP:0011839)5.39203920
3IgG deficiency (HP:0004315)4.80122698
4Aplastic anemia (HP:0001915)4.40426143
5Elevated erythrocyte sedimentation rate (HP:0003565)4.30537764
6Severe combined immunodeficiency (HP:0004430)4.25722606
7Abnormality of T cells (HP:0002843)3.92815237
8Hypoproteinemia (HP:0003075)3.85761957
9Increased IgM level (HP:0003496)3.59205425
10Autoimmune hemolytic anemia (HP:0001890)3.54392361
11Abnormality of eosinophils (HP:0001879)3.44324547
12Thyroiditis (HP:0100646)3.34533574
133-Methylglutaconic aciduria (HP:0003535)3.32264464
14Abnormality of B cell number (HP:0010975)3.29705766
15Combined immunodeficiency (HP:0005387)3.28557738
16Abolished electroretinogram (ERG) (HP:0000550)3.21729167
17Mitochondrial inheritance (HP:0001427)3.21408611
18Abnormality of the prostate (HP:0008775)3.18638974
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14816536
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14816536
21Prostate neoplasm (HP:0100787)3.08082785
22Chronic diarrhea (HP:0002028)3.05365535
23B lymphocytopenia (HP:0010976)3.04790645
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03464530
25Increased intramyocellular lipid droplets (HP:0012240)2.85394408
26Eosinophilia (HP:0001880)2.85317631
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.84704003
28Recurrent bronchitis (HP:0002837)2.84493540
29Decreased central vision (HP:0007663)2.83428589
30Acute necrotizing encephalopathy (HP:0006965)2.74637368
31Abnormal rod and cone electroretinograms (HP:0008323)2.74339748
32Congenital stationary night blindness (HP:0007642)2.70340358
33Hepatocellular necrosis (HP:0001404)2.68423660
34Renal Fanconi syndrome (HP:0001994)2.62445592
35Hypoplasia of the thymus (HP:0000778)2.60960989
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60949108
37Stomatitis (HP:0010280)2.60872313
38Cerebral hypomyelination (HP:0006808)2.59795680
39Pustule (HP:0200039)2.59331246
40Increased CSF lactate (HP:0002490)2.58530891
41Abnormal mitochondria in muscle tissue (HP:0008316)2.57003692
42Hepatic necrosis (HP:0002605)2.53500966
43Abnormality of T cell physiology (HP:0011840)2.49630020
44Increased hepatocellular lipid droplets (HP:0006565)2.48207656
45Type II lissencephaly (HP:0007260)2.46806433
46Lymphopenia (HP:0001888)2.46131018
47Leukocytosis (HP:0001974)2.45424143
48Renal cortical cysts (HP:0000803)2.44003155
49Panhypogammaglobulinemia (HP:0003139)2.42002352
50Myositis (HP:0100614)2.38489207
51Hemiplegia (HP:0002301)2.38474410
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.32755414
53Hypoalbuminemia (HP:0003073)2.32029277
54Abnormal albumin level (HP:0012116)2.32029277
55Attenuation of retinal blood vessels (HP:0007843)2.31187454
56Increased muscle lipid content (HP:0009058)2.28143945
57Cerebral edema (HP:0002181)2.24129417
58Oral leukoplakia (HP:0002745)2.16749872
59Vasculitis (HP:0002633)2.15695434
60Encephalitis (HP:0002383)2.15619530
61Increased serum lactate (HP:0002151)2.13905008
62Acute encephalopathy (HP:0006846)2.13803194
63Recurrent cutaneous fungal infections (HP:0011370)2.13579808
64Chronic mucocutaneous candidiasis (HP:0002728)2.13579808
65Granulocytopenia (HP:0001913)2.13076780
66Optic neuritis (HP:0100653)2.09974974
67Retrobulbar optic neuritis (HP:0100654)2.09974974
68Lymphoma (HP:0002665)2.09371319
69Progressive macrocephaly (HP:0004481)2.09217546
70Pulmonary infiltrates (HP:0002113)2.08810858
71Meningitis (HP:0001287)2.07802138
72Lipid accumulation in hepatocytes (HP:0006561)2.07206590
73Hypergammaglobulinemia (HP:0010702)2.06885173
74Recurrent fungal infections (HP:0002841)2.06744569
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05047247
76Optic disc pallor (HP:0000543)2.03741986
77Autoimmune thrombocytopenia (HP:0001973)2.00247732
78Pancreatic cysts (HP:0001737)1.99428772
79Pendular nystagmus (HP:0012043)1.95887117
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94530411
81Palpebral edema (HP:0100540)1.94215313
82Keratoconjunctivitis (HP:0001096)1.92746240
83Delusions (HP:0000746)1.90687386
84Pancytopenia (HP:0001876)1.89694651
85Carpal bone hypoplasia (HP:0001498)1.86856426
86Amyotrophic lateral sclerosis (HP:0007354)1.80363942
87Lactic acidosis (HP:0003128)1.77397388
88Abnormality of the renal cortex (HP:0011035)1.77326319
89IgM deficiency (HP:0002850)1.77193904
90Agammaglobulinemia (HP:0004432)1.76706070
91Recurrent viral infections (HP:0004429)1.76387373
92True hermaphroditism (HP:0010459)1.74862627
93Constricted visual fields (HP:0001133)1.74481445
94Keratoconjunctivitis sicca (HP:0001097)1.72939107
95Generalized aminoaciduria (HP:0002909)1.72852275
96Retinal dysplasia (HP:0007973)1.72226073
97Abnormality of midbrain morphology (HP:0002418)1.71945372
98Molar tooth sign on MRI (HP:0002419)1.71945372
99Gangrene (HP:0100758)1.71448466
100Orchitis (HP:0100796)1.70475868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.87543221
2KDR4.58478623
3TESK24.02233210
4TESK13.64941317
5STK163.23474950
6MAP3K123.07968048
7BCKDK3.02834736
8TAOK32.93811332
9ITK2.35245251
10BUB12.28756656
11ADRBK22.26247367
12MAP4K12.23673902
13MST42.22415800
14VRK22.21973814
15FES2.09010071
16GRK61.89116974
17ZAK1.86482045
18LIMK11.84358480
19TLK11.82367963
20TBK11.58628441
21EIF2AK31.53145264
22NUAK11.52966172
23WNK41.51087413
24SYK1.45503161
25VRK11.44211072
26DAPK11.35438559
27MYLK1.29556204
28MAPKAPK31.27618839
29TRIM281.22946399
30GRK11.22313520
31PRKCQ1.20250835
32CSK1.18409840
33ZAP701.14205364
34IKBKB1.08583275
35TIE11.03643480
36GRK71.03132848
37PINK11.02724103
38CSNK1G31.02605276
39PHKG11.00642170
40PHKG21.00642170
41IKBKE0.98155763
42TEC0.97190487
43MAP3K110.95973460
44LCK0.95668519
45JAK30.91220161
46CSF1R0.83138617
47LYN0.73972439
48CSNK1G20.70826474
49MAP4K20.70686039
50CLK10.69627094
51CSNK1G10.67150335
52BTK0.65448028
53CSNK1A1L0.63820370
54DYRK20.63439145
55MUSK0.63087070
56PLK20.63036636
57BLK0.60331671
58GRK50.56265275
59PIK3CG0.55681775
60MATK0.54552548
61RIPK40.52812931
62PIK3CA0.51968970
63EIF2AK20.51279885
64AURKA0.47657640
65DAPK30.45616371
66ILK0.44944149
67TAF10.44607075
68OXSR10.44309368
69ROCK10.44235834
70KIT0.43966843
71IGF1R0.43846990
72INSRR0.42664976
73TYRO30.42581106
74RPS6KA40.39293039
75MAPKAPK50.38670647
76MAP2K60.36632556
77STK390.36125384
78INSR0.35604982
79FYN0.34818703
80SCYL20.34704899
81RPS6KA50.34536482
82MAPKAPK20.34494886
83BMPR20.33981714
84ADRBK10.32072102
85JAK10.31103275
86PRKCA0.29935763
87PIM10.27168980
88PAK30.26384393
89NTRK10.25877200
90MAP2K70.25827161
91LMTK20.24997062
92BMPR1B0.24643912
93PRKACA0.24051772
94OBSCN0.23265183
95HCK0.22728632
96EPHA30.20861834
97CSNK2A10.20569212
98PRKCE0.20299192
99ALK0.20014469
100NEK90.19268055

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.12488990
2Proteasome_Homo sapiens_hsa030504.33898081
3Graft-versus-host disease_Homo sapiens_hsa053324.06981709
4Allograft rejection_Homo sapiens_hsa053303.44127992
5Autoimmune thyroid disease_Homo sapiens_hsa053203.39078218
6Antigen processing and presentation_Homo sapiens_hsa046123.02530100
7Type I diabetes mellitus_Homo sapiens_hsa049402.84501946
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63500291
9Oxidative phosphorylation_Homo sapiens_hsa001902.36627846
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35704279
11Hematopoietic cell lineage_Homo sapiens_hsa046402.23311611
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.21188857
13Parkinsons disease_Homo sapiens_hsa050122.18823059
14Rheumatoid arthritis_Homo sapiens_hsa053232.18303332
15T cell receptor signaling pathway_Homo sapiens_hsa046601.91490189
16Protein export_Homo sapiens_hsa030601.72101379
17Asthma_Homo sapiens_hsa053101.71856217
18Viral myocarditis_Homo sapiens_hsa054161.69455502
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.64167385
20Salmonella infection_Homo sapiens_hsa051321.54837942
21Alzheimers disease_Homo sapiens_hsa050101.50784169
22RNA polymerase_Homo sapiens_hsa030201.50729457
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48143648
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45227371
25Measles_Homo sapiens_hsa051621.42317734
26Linoleic acid metabolism_Homo sapiens_hsa005911.37752140
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36063775
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33847911
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28995756
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27819041
31Cardiac muscle contraction_Homo sapiens_hsa042601.25486271
32Huntingtons disease_Homo sapiens_hsa050161.18406510
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17227313
34Nitrogen metabolism_Homo sapiens_hsa009101.13072467
35Systemic lupus erythematosus_Homo sapiens_hsa053221.04301825
36Phototransduction_Homo sapiens_hsa047441.00620406
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95506643
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92754142
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90714596
40Shigellosis_Homo sapiens_hsa051310.89859421
41Peroxisome_Homo sapiens_hsa041460.86392620
42Sulfur metabolism_Homo sapiens_hsa009200.84355354
43Herpes simplex infection_Homo sapiens_hsa051680.80548594
44Epstein-Barr virus infection_Homo sapiens_hsa051690.76712726
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74246806
46Pyrimidine metabolism_Homo sapiens_hsa002400.73779303
47Tryptophan metabolism_Homo sapiens_hsa003800.73755745
48Malaria_Homo sapiens_hsa051440.63698729
49Caffeine metabolism_Homo sapiens_hsa002320.63629059
50Regulation of autophagy_Homo sapiens_hsa041400.61304367
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59714715
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59102129
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57778834
54Purine metabolism_Homo sapiens_hsa002300.57374582
55Ether lipid metabolism_Homo sapiens_hsa005650.57137390
56Legionellosis_Homo sapiens_hsa051340.56289569
57Chemokine signaling pathway_Homo sapiens_hsa040620.51493444
58Basal transcription factors_Homo sapiens_hsa030220.50815101
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49502297
60Apoptosis_Homo sapiens_hsa042100.48774327
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46466592
62Arachidonic acid metabolism_Homo sapiens_hsa005900.45380605
63TNF signaling pathway_Homo sapiens_hsa046680.45244996
64Propanoate metabolism_Homo sapiens_hsa006400.44497912
65Ribosome_Homo sapiens_hsa030100.42852525
66Chemical carcinogenesis_Homo sapiens_hsa052040.38233019
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37057292
68Selenocompound metabolism_Homo sapiens_hsa004500.37029087
69Platelet activation_Homo sapiens_hsa046110.36683198
70Viral carcinogenesis_Homo sapiens_hsa052030.35912714
71Spliceosome_Homo sapiens_hsa030400.35891126
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35053415
73RNA degradation_Homo sapiens_hsa030180.33505911
74Leishmaniasis_Homo sapiens_hsa051400.33387056
75Non-homologous end-joining_Homo sapiens_hsa034500.32989239
76Staphylococcus aureus infection_Homo sapiens_hsa051500.32595517
77Olfactory transduction_Homo sapiens_hsa047400.32559580
78Retinol metabolism_Homo sapiens_hsa008300.32470582
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32300277
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.32242413
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31092617
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29857256
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28443453
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27672214
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26663741
86Nucleotide excision repair_Homo sapiens_hsa034200.26632875
87Pertussis_Homo sapiens_hsa051330.25549932
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23185692
89Endocytosis_Homo sapiens_hsa041440.23022696
90Serotonergic synapse_Homo sapiens_hsa047260.22115564
91Alcoholism_Homo sapiens_hsa050340.22028975
92RNA transport_Homo sapiens_hsa030130.21956935
93Fatty acid elongation_Homo sapiens_hsa000620.21418451
94Fanconi anemia pathway_Homo sapiens_hsa034600.20896083
95Mismatch repair_Homo sapiens_hsa034300.19814006
96Collecting duct acid secretion_Homo sapiens_hsa049660.19741503
97Fat digestion and absorption_Homo sapiens_hsa049750.19323704
98Lysosome_Homo sapiens_hsa041420.19053719
99Homologous recombination_Homo sapiens_hsa034400.18401577
100HTLV-I infection_Homo sapiens_hsa051660.17921434

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