CAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)5.38903110
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.00531986
3actin filament-based movement (GO:0030048)4.88711081
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.83391868
5synaptic vesicle maturation (GO:0016188)4.80483773
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74823191
7locomotory exploration behavior (GO:0035641)4.69113909
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.65420237
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58616851
10synaptic vesicle exocytosis (GO:0016079)4.53620643
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.52921158
12vocalization behavior (GO:0071625)4.50165091
13neuronal action potential propagation (GO:0019227)4.47308863
14glutamate secretion (GO:0014047)4.46827625
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.39303425
16regulation of glutamate receptor signaling pathway (GO:1900449)4.32252474
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.24933294
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15682847
19regulation of synapse structural plasticity (GO:0051823)4.08831663
20regulation of synaptic vesicle exocytosis (GO:2000300)4.07351139
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.07041827
22response to muscle activity (GO:0014850)4.03051293
23skeletal muscle fiber development (GO:0048741)3.99058509
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.96441322
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.93197748
26response to inactivity (GO:0014854)3.90797339
27cell communication by electrical coupling (GO:0010644)3.90182146
28negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.89289984
29actomyosin structure organization (GO:0031032)3.88919637
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.86978581
31muscle contraction (GO:0006936)3.83469801
32protein localization to synapse (GO:0035418)3.81313681
33regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.80735380
34regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.79203622
35regulation of synaptic vesicle transport (GO:1902803)3.78398809
36neurotransmitter-gated ion channel clustering (GO:0072578)3.73669028
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.73615889
38cardiac myofibril assembly (GO:0055003)3.73469213
39creatine metabolic process (GO:0006600)3.73011144
40sarcoplasmic reticulum calcium ion transport (GO:0070296)3.70556845
41regulation of neuronal synaptic plasticity (GO:0048168)3.70425742
42myotube cell development (GO:0014904)3.69101338
43regulation of cell communication by electrical coupling (GO:0010649)3.67118349
44regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.66037067
45muscle filament sliding (GO:0030049)3.63222459
46actin-myosin filament sliding (GO:0033275)3.63222459
47muscle cell cellular homeostasis (GO:0046716)3.59955504
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59878051
49synaptic transmission, glutamatergic (GO:0035249)3.59723260
50regulation of membrane repolarization (GO:0060306)3.56764656
51cardiac muscle contraction (GO:0060048)3.56455196
52glutamate receptor signaling pathway (GO:0007215)3.56097710
53negative regulation of potassium ion transmembrane transport (GO:1901380)3.52338522
54muscle fiber development (GO:0048747)3.50096896
55neurotransmitter secretion (GO:0007269)3.49868923
56exploration behavior (GO:0035640)3.48078671
57plasma membrane repair (GO:0001778)3.45795120
58neuron-neuron synaptic transmission (GO:0007270)3.45469750
59sarcomere organization (GO:0045214)3.44630206
60myofibril assembly (GO:0030239)3.44350588
61regulation of dendritic spine morphogenesis (GO:0061001)3.43203479
62cardiac muscle cell development (GO:0055013)3.42601167
63muscle system process (GO:0003012)3.42424985
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.40799083
65cellular potassium ion homeostasis (GO:0030007)3.37426198
66regulation of calcium ion transmembrane transporter activity (GO:1901019)3.36365200
67regulation of calcium ion transmembrane transport (GO:1903169)3.36365200
68detection of calcium ion (GO:0005513)3.35900951
69regulation of striated muscle contraction (GO:0006942)3.35763972
70long-term memory (GO:0007616)3.34976671
71neuromuscular synaptic transmission (GO:0007274)3.34577387
72membrane depolarization during action potential (GO:0086010)3.33832544
73activation of protein kinase A activity (GO:0034199)3.32318362
74sodium ion export (GO:0071436)3.31203175
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31102275
76regulation of sarcomere organization (GO:0060297)3.29679693
77negative regulation of protein localization to cell surface (GO:2000009)3.27182611
78cell communication involved in cardiac conduction (GO:0086065)3.26479093
79negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.25651903
80negative regulation of calcium ion transmembrane transport (GO:1903170)3.25651903
81striated muscle contraction (GO:0006941)3.23674773
82regulation of postsynaptic membrane potential (GO:0060078)3.19686387
83regulation of synaptic plasticity (GO:0048167)3.16659074
84cardiac cell development (GO:0055006)3.16342315
85regulation of the force of heart contraction (GO:0002026)3.16033444
86neuron cell-cell adhesion (GO:0007158)3.14380548
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.12124165
88regulation of voltage-gated calcium channel activity (GO:1901385)3.10806024
89dendritic spine morphogenesis (GO:0060997)3.10570500
90postsynaptic membrane organization (GO:0001941)3.10409852
91positive regulation of synapse maturation (GO:0090129)3.09349674
92positive regulation of membrane potential (GO:0045838)3.08630458
93adult heart development (GO:0007512)3.04901600
94long-term synaptic potentiation (GO:0060291)3.03121243
95striated muscle cell development (GO:0055002)3.02880067
96muscle tissue morphogenesis (GO:0060415)3.01796783
97positive regulation of potassium ion transmembrane transport (GO:1901381)3.01551029
98cardiac muscle tissue morphogenesis (GO:0055008)3.01017437
99muscle hypertrophy (GO:0014896)2.99813182
100potassium ion import (GO:0010107)2.99747697
101layer formation in cerebral cortex (GO:0021819)2.99189589
102myotube differentiation (GO:0014902)2.99023944
103regulation of ion transmembrane transporter activity (GO:0032412)2.98718359
104regulation of actin filament-based movement (GO:1903115)2.95777133
105regulation of skeletal muscle contraction (GO:0014819)2.94792514
106negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94746944
107skeletal muscle tissue development (GO:0007519)2.94555671
108striated muscle adaptation (GO:0014888)2.94151979
109NADH metabolic process (GO:0006734)2.93365775
110cardiac conduction (GO:0061337)2.93064262
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93035922
112positive regulation of neurotransmitter secretion (GO:0001956)2.92811875
113membrane depolarization (GO:0051899)2.92726559
114regulation of acyl-CoA biosynthetic process (GO:0050812)2.92099816
115cardiac muscle hypertrophy in response to stress (GO:0014898)2.91796874
116muscle hypertrophy in response to stress (GO:0003299)2.91796874
117cardiac muscle adaptation (GO:0014887)2.91796874
118regulation of cation channel activity (GO:2001257)2.90917509
119regulation of dendritic spine development (GO:0060998)2.90657841
120actin-mediated cell contraction (GO:0070252)2.90459651
121regulation of transmembrane transporter activity (GO:0022898)2.90390759
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89857878
123cardiac muscle hypertrophy (GO:0003300)2.89150615
124gamma-aminobutyric acid transport (GO:0015812)2.88842667
125gamma-aminobutyric acid signaling pathway (GO:0007214)2.86174198
126regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.85084624
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.84706510
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84035328
129tricarboxylic acid cycle (GO:0006099)2.83610702
130negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.83427585
131regulation of cardiac muscle cell contraction (GO:0086004)2.83050416
132striated muscle hypertrophy (GO:0014897)2.81889499
133heart contraction (GO:0060047)2.81370954
134heart process (GO:0003015)2.81370954
135myoblast fusion (GO:0007520)2.81339227
136positive regulation of neurotransmitter transport (GO:0051590)2.81165909
137regulation of neurotransmitter secretion (GO:0046928)2.80947658
138neuromuscular process controlling balance (GO:0050885)2.79933552
139striatum development (GO:0021756)2.79257328
140regulation of relaxation of muscle (GO:1901077)2.78666774
141relaxation of muscle (GO:0090075)2.77558501
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75914309
143regulation of sodium ion transmembrane transport (GO:1902305)2.74035725
144glycogen catabolic process (GO:0005980)2.73161838
145relaxation of cardiac muscle (GO:0055119)2.66667204
146regulation of sodium ion transmembrane transporter activity (GO:2000649)2.62813018
147muscle structure development (GO:0061061)2.62392124
148muscle organ development (GO:0007517)2.62277650
149muscle cell fate commitment (GO:0042693)2.61524927
150skeletal muscle adaptation (GO:0043501)2.59772535
151regulation of potassium ion transmembrane transporter activity (GO:1901016)2.57983597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19668749
2GBX2_23144817_ChIP-Seq_PC3_Human3.21380376
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04464131
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00646820
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86797809
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.78986336
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69606627
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69606627
9DROSHA_22980978_ChIP-Seq_HELA_Human2.55491283
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50124613
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48715325
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47050996
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45669819
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.40033065
15REST_21632747_ChIP-Seq_MESCs_Mouse2.38101825
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34866431
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34785706
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.17271543
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.16060781
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10562094
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.07969858
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.05271571
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.04046054
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96560509
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95834916
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73989943
27AR_21572438_ChIP-Seq_LNCaP_Human1.66951857
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63638508
29SMAD4_21799915_ChIP-Seq_A2780_Human1.61158539
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60898665
31* EP300_21415370_ChIP-Seq_HL-1_Mouse1.58849982
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57984135
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52891480
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50468698
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50101962
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49790171
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49010330
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48023373
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47276958
40* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46878729
41ZNF274_21170338_ChIP-Seq_K562_Hela1.45636930
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42090405
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42000747
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.39937970
45TAF15_26573619_Chip-Seq_HEK293_Human1.39647146
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36349667
47* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36336416
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35268681
49IGF1R_20145208_ChIP-Seq_DFB_Human1.33228816
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32082182
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.31935708
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30399004
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.29043530
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.29043530
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28630821
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28520002
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.26473593
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25618498
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.24798938
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23151122
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22452970
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.22244282
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20218311
64* AR_19668381_ChIP-Seq_PC3_Human1.19677912
65AR_25329375_ChIP-Seq_VCAP_Human1.16857678
66SOX9_26525672_Chip-Seq_HEART_Mouse1.16377510
67* P300_19829295_ChIP-Seq_ESCs_Human1.15710303
68RNF2_27304074_Chip-Seq_NSC_Mouse1.15095748
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14557438
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13940642
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12571606
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.12289679
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11598178
74* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11233243
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11179194
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11126595
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10660367
78STAT3_23295773_ChIP-Seq_U87_Human1.09393473
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08853295
80* ISL1_27105846_Chip-Seq_CPCs_Mouse1.08133402
81* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08067502
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07108441
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.06979153
84* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05710798
85* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05710798
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05253941
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03675981
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.03545337
89TCF4_23295773_ChIP-Seq_U87_Human1.03008445
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.02330327
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01552674
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00812809
93TP53_16413492_ChIP-PET_HCT116_Human1.00335776
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00286304
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00270977
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99709402
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98911897
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98047737
99* ESR1_20079471_ChIP-ChIP_T-47D_Human0.97395503
100AHR_22903824_ChIP-Seq_MCF-7_Human0.97126192
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95987695
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94854695
103* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94622050
104* FUS_26573619_Chip-Seq_HEK293_Human0.94420102
105KDM2B_26808549_Chip-Seq_K562_Human0.94214880
106BCAT_22108803_ChIP-Seq_LS180_Human0.93973755
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93739520
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93690269
109TP53_18474530_ChIP-ChIP_U2OS_Human0.93550241
110RXR_22108803_ChIP-Seq_LS180_Human0.93155704
111CTCF_27219007_Chip-Seq_Bcells_Human0.93111989
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92348145
113* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91934620
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.91718099
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91106750
116* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89986548
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89769749
118* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89538821
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88380501
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88008633
121VDR_22108803_ChIP-Seq_LS180_Human0.87672276
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.87498106
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86112226
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.84470814
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83742395
126* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82767273
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80864854
128RUNX2_22187159_ChIP-Seq_PCA_Human0.80695660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86524341
2MP0003880_abnormal_central_pattern4.00589930
3MP0000751_myopathy3.50539210
4MP0003635_abnormal_synaptic_transmissio3.47651779
5MP0002837_dystrophic_cardiac_calcinosis3.45799268
6MP0004270_analgesia3.22964904
7MP0003646_muscle_fatigue3.10870867
8MP0004145_abnormal_muscle_electrophysio2.91956470
9MP0009745_abnormal_behavioral_response2.88024688
10MP0002822_catalepsy2.76696333
11MP0002063_abnormal_learning/memory/cond2.76254021
12MP0000749_muscle_degeneration2.74588929
13MP0004215_abnormal_myocardial_fiber2.66548715
14MP0002064_seizures2.60511092
15MP0004036_abnormal_muscle_relaxation2.53861720
16MP0009046_muscle_twitch2.53810010
17MP0004084_abnormal_cardiac_muscle2.52925347
18MP0001968_abnormal_touch/_nociception2.25981752
19MP0002572_abnormal_emotion/affect_behav2.22585823
20MP0002272_abnormal_nervous_system2.12732707
21MP0001486_abnormal_startle_reflex2.01514677
22MP0005620_abnormal_muscle_contractility1.91688541
23MP0002734_abnormal_mechanical_nocicepti1.90146452
24MP0005330_cardiomyopathy1.80369209
25MP0002736_abnormal_nociception_after1.78039664
26MP0004484_altered_response_of1.77061467
27MP0004087_abnormal_muscle_fiber1.75600774
28MP0009780_abnormal_chondrocyte_physiolo1.74562354
29MP0003137_abnormal_impulse_conducting1.73602253
30MP0001501_abnormal_sleep_pattern1.70789766
31MP0008569_lethality_at_weaning1.69984109
32MP0001440_abnormal_grooming_behavior1.69871286
33MP0004233_abnormal_muscle_weight1.69511220
34MP0002106_abnormal_muscle_physiology1.68439213
35MP0002972_abnormal_cardiac_muscle1.66898178
36MP0000747_muscle_weakness1.64551370
37MP0004085_abnormal_heartbeat1.62249398
38MP0004130_abnormal_muscle_cell1.59917212
39MP0005423_abnormal_somatic_nervous1.59023755
40MP0002067_abnormal_sensory_capabilities1.54685675
41MP0002909_abnormal_adrenal_gland1.53392521
42MP0002269_muscular_atrophy1.49381426
43MP0005369_muscle_phenotype1.43093386
44MP0005386_behavior/neurological_phenoty1.42820398
45MP0004924_abnormal_behavior1.42820398
46MP0000759_abnormal_skeletal_muscle1.42395286
47MP0002735_abnormal_chemical_nociception1.41869247
48MP0000733_abnormal_muscle_development1.39441728
49MP0004510_myositis1.38084131
50MP0005646_abnormal_pituitary_gland1.36064867
51MP0003950_abnormal_plasma_membrane1.35954427
52MP0003329_amyloid_beta_deposits1.35154365
53MP0001299_abnormal_eye_distance/1.34007243
54MP0001970_abnormal_pain_threshold1.30626880
55MP0003879_abnormal_hair_cell1.28770017
56MP0004811_abnormal_neuron_physiology1.27887862
57MP0008775_abnormal_heart_ventricle1.23596664
58MP0004858_abnormal_nervous_system1.21756447
59MP0006138_congestive_heart_failure1.20773084
60MP0002557_abnormal_social/conspecific_i1.20483393
61MP0002733_abnormal_thermal_nociception1.20298881
62MP0010030_abnormal_orbit_morphology1.19645466
63MP0000750_abnormal_muscle_regeneration1.17636513
64MP0002066_abnormal_motor_capabilities/c1.14330973
65MP0002184_abnormal_innervation1.13459123
66MP0003633_abnormal_nervous_system1.10992606
67MP0000013_abnormal_adipose_tissue1.09409987
68MP0001529_abnormal_vocalization1.09138444
69MP0005385_cardiovascular_system_phenoty1.09091517
70MP0001544_abnormal_cardiovascular_syste1.09091517
71MP0001984_abnormal_olfaction1.09026819
72MP0000778_abnormal_nervous_system1.03094163
73MP0003122_maternal_imprinting1.00827882
74MP0000955_abnormal_spinal_cord1.00438485
75MP0002882_abnormal_neuron_morphology0.98903507
76MP0001346_abnormal_lacrimal_gland0.96185830
77MP0003787_abnormal_imprinting0.95640364
78MP0010630_abnormal_cardiac_muscle0.95252577
79MP0004147_increased_porphyrin_level0.94949108
80MP0005187_abnormal_penis_morphology0.88739131
81MP0001502_abnormal_circadian_rhythm0.88737357
82MP0002332_abnormal_exercise_endurance0.88287867
83MP0003631_nervous_system_phenotype0.85710776
84MP0008874_decreased_physiological_sensi0.85602566
85MP0004142_abnormal_muscle_tone0.85295541
86MP0002638_abnormal_pupillary_reflex0.84403515
87MP0001905_abnormal_dopamine_level0.82194241
88MP0005623_abnormal_meninges_morphology0.81776244
89MP0002234_abnormal_pharynx_morphology0.81338156
90MP0004885_abnormal_endolymph0.80286789
91MP0005451_abnormal_body_composition0.79134817
92MP0002102_abnormal_ear_morphology0.77754577
93MP0005171_absent_coat_pigmentation0.77535645
94MP0002127_abnormal_cardiovascular_syste0.77226659
95MP0003075_altered_response_to0.76963699
96MP0008961_abnormal_basal_metabolism0.76482352
97MP0005535_abnormal_body_temperature0.75427139
98MP0006276_abnormal_autonomic_nervous0.74752633
99MP0002152_abnormal_brain_morphology0.74282776
100MP0000534_abnormal_ureter_morphology0.72905330
101MP0002108_abnormal_muscle_morphology0.71767274
102MP0006036_abnormal_mitochondrial_physio0.70786204
103MP0004043_abnormal_pH_regulation0.69885935
104MP0003136_yellow_coat_color0.68785600
105MP0008872_abnormal_physiological_respon0.67024254
106MP0003385_abnormal_body_wall0.66771603
107MP0002069_abnormal_eating/drinking_beha0.66665003
108MP0005248_abnormal_Harderian_gland0.62810350
109MP0001177_atelectasis0.62441518
110MP0006035_abnormal_mitochondrial_morpho0.62140696
111MP0000762_abnormal_tongue_morphology0.61894627
112MP0002971_abnormal_brown_adipose0.61881512
113MP0003123_paternal_imprinting0.61021196
114MP0002229_neurodegeneration0.60734071
115MP0005266_abnormal_metabolism0.60646429
116MP0009250_abnormal_appendicular_skeleto0.60324351
117MP0005167_abnormal_blood-brain_barrier0.60107775
118MP0000372_irregular_coat_pigmentation0.58442661
119MP0000230_abnormal_systemic_arterial0.57518875
120MP0003221_abnormal_cardiomyocyte_apopto0.56969934
121MP0000266_abnormal_heart_morphology0.55998384
122MP0001485_abnormal_pinna_reflex0.55793479
123MP0002090_abnormal_vision0.53417822
124MP0002752_abnormal_somatic_nervous0.52824241

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.53887919
2Exercise-induced myalgia (HP:0003738)5.55085403
3Myokymia (HP:0002411)5.20139645
4Sudden death (HP:0001699)5.07096985
5Exercise-induced muscle cramps (HP:0003710)4.76112514
6Calf muscle hypertrophy (HP:0008981)4.72342474
7Muscle hypertrophy of the lower extremities (HP:0008968)4.71925339
8Focal seizures (HP:0007359)4.35066850
9Abnormality of the calf musculature (HP:0001430)4.00358300
10Visual hallucinations (HP:0002367)3.83985843
11Epileptic encephalopathy (HP:0200134)3.83385956
12Ulnar deviation of the wrist (HP:0003049)3.76203376
13Atonic seizures (HP:0010819)3.62960620
14Calcaneovalgus deformity (HP:0001848)3.62357993
15Atrial fibrillation (HP:0005110)3.51542933
16Bundle branch block (HP:0011710)3.43949360
17Primary atrial arrhythmia (HP:0001692)3.40207041
18Muscle fiber inclusion bodies (HP:0100299)3.38594472
19Febrile seizures (HP:0002373)3.35823390
20EMG: myopathic abnormalities (HP:0003458)3.31436654
21Ventricular fibrillation (HP:0001663)3.27260682
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.27110207
23Supraventricular tachycardia (HP:0004755)3.23898428
24Deformed tarsal bones (HP:0008119)3.22919003
25Absence seizures (HP:0002121)3.21144082
26Syncope (HP:0001279)3.20409017
27Muscle fiber splitting (HP:0003555)3.15352424
28Supraventricular arrhythmia (HP:0005115)3.15264301
29Hyporeflexia of lower limbs (HP:0002600)3.13255246
30Type 1 muscle fiber predominance (HP:0003803)3.12668047
31Generalized tonic-clonic seizures (HP:0002069)3.11103561
32Prolonged QT interval (HP:0001657)3.10847455
33Myoglobinuria (HP:0002913)3.08634917
34Abnormality of the left ventricular outflow tract (HP:0011103)3.08026964
35Subaortic stenosis (HP:0001682)3.08026964
36Absent phalangeal crease (HP:0006109)3.05961116
37Distal lower limb muscle weakness (HP:0009053)3.04674034
38Myotonia (HP:0002486)3.03939708
39Broad-based gait (HP:0002136)3.03221884
40Progressive cerebellar ataxia (HP:0002073)2.96657600
41Difficulty running (HP:0009046)2.96000661
42Dialeptic seizures (HP:0011146)2.92740412
43Dysmetric saccades (HP:0000641)2.92428076
44Impaired vibration sensation in the lower limbs (HP:0002166)2.89301356
45Poor eye contact (HP:0000817)2.87727387
46Areflexia of lower limbs (HP:0002522)2.84826852
47Nemaline bodies (HP:0003798)2.84661218
48Hyperventilation (HP:0002883)2.81398978
49Frequent falls (HP:0002359)2.80091658
50Abnormal EKG (HP:0003115)2.79195589
51Malignant hyperthermia (HP:0002047)2.77566427
52Ventricular arrhythmia (HP:0004308)2.77154955
53Dysdiadochokinesis (HP:0002075)2.68842594
54Ventricular tachycardia (HP:0004756)2.68356487
55Gowers sign (HP:0003391)2.63536315
56Action tremor (HP:0002345)2.63518604
57Abnormal social behavior (HP:0012433)2.58138786
58Impaired social interactions (HP:0000735)2.58138786
59Gaze-evoked nystagmus (HP:0000640)2.57868400
60Heart block (HP:0012722)2.57800400
61Popliteal pterygium (HP:0009756)2.57324107
62Depression (HP:0000716)2.54873171
63Anxiety (HP:0000739)2.52065116
64Pheochromocytoma (HP:0002666)2.49149862
65Abnormal finger flexion creases (HP:0006143)2.47533528
66Fetal akinesia sequence (HP:0001989)2.41639649
67Increased variability in muscle fiber diameter (HP:0003557)2.41414435
68Weak cry (HP:0001612)2.41123616
69Abnormal atrioventricular conduction (HP:0005150)2.36546304
70Urinary bladder sphincter dysfunction (HP:0002839)2.35623443
71Amblyopia (HP:0000646)2.35458831
72Dysmetria (HP:0001310)2.34813981
73Round ear (HP:0100830)2.34261045
74Fatigable weakness (HP:0003473)2.31133006
75Abnormality of the neuromuscular junction (HP:0003398)2.31133006
76Ankle clonus (HP:0011448)2.28911203
77Asymmetric septal hypertrophy (HP:0001670)2.28243029
78Distal arthrogryposis (HP:0005684)2.26952472
79Generalized muscle weakness (HP:0003324)2.26574202
80Left ventricular hypertrophy (HP:0001712)2.25094426
81Lower limb amyotrophy (HP:0007210)2.24944522
82Abnormality of skeletal muscle fiber size (HP:0012084)2.23953220
83Postural instability (HP:0002172)2.22692877
84Limb-girdle muscle atrophy (HP:0003797)2.21007042
85Scapular winging (HP:0003691)2.20194673
86Atrioventricular block (HP:0001678)2.19490488
87Type 2 muscle fiber atrophy (HP:0003554)2.19340140
88Urinary urgency (HP:0000012)2.19124654
89Lipoatrophy (HP:0100578)2.17444852
90Muscle stiffness (HP:0003552)2.17316832
91Difficulty climbing stairs (HP:0003551)2.15353471
92Neuroendocrine neoplasm (HP:0100634)2.15151855
93Hip contracture (HP:0003273)2.13681429
94Truncal ataxia (HP:0002078)2.07086203
95Neck muscle weakness (HP:0000467)2.03433110
96Abnormality of the calcaneus (HP:0008364)2.02209909
97Abnormality of the foot musculature (HP:0001436)2.01122491
98Distal lower limb amyotrophy (HP:0008944)1.99347122
99Myopathic facies (HP:0002058)1.99293940
100Right ventricular cardiomyopathy (HP:0011663)1.98452497
101Impaired vibratory sensation (HP:0002495)1.98161444
102Centrally nucleated skeletal muscle fibers (HP:0003687)1.98133750
103Proximal amyotrophy (HP:0007126)1.94904836
104Genetic anticipation (HP:0003743)1.94790693
105Resting tremor (HP:0002322)1.93990280
106Palpitations (HP:0001962)1.93921820
107Increased connective tissue (HP:0009025)1.93191323
108Respiratory insufficiency due to muscle weakness (HP:0002747)1.92432658
109Abnormality of the lower motor neuron (HP:0002366)1.92166119
110Slender build (HP:0001533)1.91274724
111EMG: neuropathic changes (HP:0003445)1.89151464
112Muscle fiber atrophy (HP:0100295)1.89041000
113Bulbar palsy (HP:0001283)1.88538302
114Spinal rigidity (HP:0003306)1.87964077
115Abnormality of the shoulder girdle musculature (HP:0001435)1.86685178
116Dilated cardiomyopathy (HP:0001644)1.86310292
117Scanning speech (HP:0002168)1.82687258
118Shoulder girdle muscle weakness (HP:0003547)1.82148093
119Foot dorsiflexor weakness (HP:0009027)1.82037077
120Rapidly progressive (HP:0003678)1.81959177
121Rhabdomyolysis (HP:0003201)1.80259500
122Impaired smooth pursuit (HP:0007772)1.78905076
123Incomplete penetrance (HP:0003829)1.78737846
124Abnormal eating behavior (HP:0100738)1.77693421
125Mildly elevated creatine phosphokinase (HP:0008180)1.76353899
126Amniotic constriction ring (HP:0009775)1.76289634
127Abnormality of placental membranes (HP:0011409)1.76289634
128Central scotoma (HP:0000603)1.75637847
129Rimmed vacuoles (HP:0003805)1.75348097
130Akinesia (HP:0002304)1.75292560
131Bradykinesia (HP:0002067)1.74175890
132Progressive inability to walk (HP:0002505)1.74060899
133Abnormality of the hip-girdle musculature (HP:0001445)1.73951080
134Abnormality of the musculature of the pelvis (HP:0001469)1.73951080
135Limb-girdle muscle weakness (HP:0003325)1.72613355
136Muscular dystrophy (HP:0003560)1.71367353
137Limited hip movement (HP:0008800)1.69806904
138Waddling gait (HP:0002515)1.67671315
139Nonprogressive disorder (HP:0003680)1.67594391
140Steppage gait (HP:0003376)1.66027932
141Delayed gross motor development (HP:0002194)1.63515565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.82446274
2NTRK33.85880402
3OBSCN2.86474896
4MAP3K92.85704911
5MAP3K42.66778658
6DAPK22.45730874
7PHKG12.25645692
8PHKG22.25645692
9PRKD32.24219782
10LIMK12.20978291
11MAP2K72.08664353
12MINK12.01901536
13MAP2K41.96157132
14KSR21.94911083
15PAK61.94245385
16PDK31.76412253
17PDK41.76412253
18RIPK41.71813103
19TTN1.71759167
20KSR11.60818767
21DMPK1.60741041
22CAMKK11.60150685
23NEK11.58159682
24LMTK21.56021454
25DAPK11.55086925
26PINK11.53737083
27CASK1.51976461
28MAP3K121.51570995
29PIK3CG1.45622911
30STK381.39349625
31NTRK21.37214770
32PLK21.32378156
33CDK191.31216006
34NME11.29934833
35PRPF4B1.29757704
36CDK51.25772394
37PTK2B1.23586249
38MUSK1.22301891
39MARK11.20136818
40NTRK11.19786097
41ARAF1.14844495
42MYLK1.12711357
43CAMK2A1.08364043
44MAP3K71.06353931
45CAMK11.06182267
46PRKCG1.00398664
47TNIK0.99904649
48MAP3K130.97011940
49ERBB30.96370206
50GRK50.93417839
51TAOK10.93095941
52PDK20.93037324
53MOS0.88012383
54FES0.83649523
55SGK20.83591918
56PAK30.82421072
57CAMKK20.82414936
58PDK10.82267987
59RAF10.81133593
60SGK4940.79624745
61SGK2230.79624745
62CAMK2B0.79236093
63DAPK30.79144502
64CAMK2D0.77415617
65PIK3CA0.76934991
66SGK10.76233576
67MAPK120.75978351
68TYRO30.75959833
69WNK30.74937183
70SGK30.74800486
71PDPK10.74343581
72BMPR20.74296738
73TRIB30.73372696
74PRKCH0.72824413
75UHMK10.71887605
76CDK180.71642977
77STK110.71515454
78PNCK0.71011585
79PKN10.70728461
80MAPK130.69771299
81CDK150.68313949
82CCNB10.68129897
83CDC42BPA0.67844932
84TESK10.66977664
85MAPKAPK30.65239831
86MAP3K20.64723113
87CDK140.64385756
88SIK20.63531067
89NEK90.62842489
90TRIM280.62774144
91RET0.60813137
92STK38L0.60338422
93PKN20.59919608
94PRKG10.59332957
95CAMK2G0.59277911
96CAMK40.58921499
97CDK11A0.56971579
98OXSR10.55929260
99MAP3K10.55654799
100PRKAA10.54777812
101LATS20.52685124
102RIPK10.52595886
103DYRK1B0.50981114
104RPS6KA30.49430069
105STK240.49069840
106ROCK10.48376855
107AKT20.48339150
108BCR0.47113076
109DYRK1A0.46457233
110PRKCE0.45605035
111MAPK100.44345119
112MAP2K10.44337687
113ROCK20.43412616
114FER0.43073456
115EPHB20.42207212
116WNK10.41537924
117MAP3K50.39789588
118CSNK1G20.37531774
119PRKACA0.35406904
120BRSK10.35031263
121BRAF0.34280291
122MARK20.33843329
123PRKAA20.32756709
124STK390.31736060
125MAPK40.31289457
126PRKACB0.30825682
127WEE10.29922734
128PBK0.28854806
129TRPM70.26638232

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01343484
2Synaptic vesicle cycle_Homo sapiens_hsa047212.63396439
3Circadian entrainment_Homo sapiens_hsa047132.58654202
4Olfactory transduction_Homo sapiens_hsa047402.58644307
5Long-term potentiation_Homo sapiens_hsa047202.54458454
6Cardiac muscle contraction_Homo sapiens_hsa042602.44783310
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35120806
8Amphetamine addiction_Homo sapiens_hsa050312.30432489
9GABAergic synapse_Homo sapiens_hsa047272.25589646
10Glutamatergic synapse_Homo sapiens_hsa047242.21625715
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18939738
12Morphine addiction_Homo sapiens_hsa050322.18675533
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.15555128
14Dilated cardiomyopathy_Homo sapiens_hsa054142.03304327
15Salivary secretion_Homo sapiens_hsa049702.00251592
16Oxytocin signaling pathway_Homo sapiens_hsa049211.92731725
17Insulin secretion_Homo sapiens_hsa049111.92009471
18Gastric acid secretion_Homo sapiens_hsa049711.90130679
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88832329
20Dopaminergic synapse_Homo sapiens_hsa047281.88279580
21Calcium signaling pathway_Homo sapiens_hsa040201.87266517
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74002614
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73999955
24Renin secretion_Homo sapiens_hsa049241.73030595
25Cholinergic synapse_Homo sapiens_hsa047251.65462368
26Arginine and proline metabolism_Homo sapiens_hsa003301.45525557
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44175686
28Taste transduction_Homo sapiens_hsa047421.43592541
29Long-term depression_Homo sapiens_hsa047301.41704103
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39467390
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.38527440
32GnRH signaling pathway_Homo sapiens_hsa049121.36610049
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35167148
34cAMP signaling pathway_Homo sapiens_hsa040241.28881554
35Serotonergic synapse_Homo sapiens_hsa047261.27403566
36Cocaine addiction_Homo sapiens_hsa050301.26730178
37Collecting duct acid secretion_Homo sapiens_hsa049661.21967521
38Gap junction_Homo sapiens_hsa045401.17159202
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16745487
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.15261184
41Alzheimers disease_Homo sapiens_hsa050101.11473499
42Type II diabetes mellitus_Homo sapiens_hsa049301.11165083
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09220333
44Oxidative phosphorylation_Homo sapiens_hsa001901.07977291
45Glucagon signaling pathway_Homo sapiens_hsa049221.07208722
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06487359
47Parkinsons disease_Homo sapiens_hsa050121.06157892
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05771763
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05706200
50Biosynthesis of amino acids_Homo sapiens_hsa012301.00129583
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98747245
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95937246
53Glioma_Homo sapiens_hsa052140.94003339
54Estrogen signaling pathway_Homo sapiens_hsa049150.92039796
55Melanogenesis_Homo sapiens_hsa049160.91969891
56Nitrogen metabolism_Homo sapiens_hsa009100.87793509
57Fatty acid degradation_Homo sapiens_hsa000710.85398542
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79531459
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79390644
60Circadian rhythm_Homo sapiens_hsa047100.79099541
61ErbB signaling pathway_Homo sapiens_hsa040120.77373183
62Pancreatic secretion_Homo sapiens_hsa049720.76849576
63Fatty acid metabolism_Homo sapiens_hsa012120.76246880
64Oocyte meiosis_Homo sapiens_hsa041140.73947621
65Dorso-ventral axis formation_Homo sapiens_hsa043200.73366005
66Hippo signaling pathway_Homo sapiens_hsa043900.72472859
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71671239
68Axon guidance_Homo sapiens_hsa043600.70584993
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70161532
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69879705
71Phenylalanine metabolism_Homo sapiens_hsa003600.69242789
72Insulin signaling pathway_Homo sapiens_hsa049100.69171093
73beta-Alanine metabolism_Homo sapiens_hsa004100.68762142
74Butanoate metabolism_Homo sapiens_hsa006500.67546904
75Vibrio cholerae infection_Homo sapiens_hsa051100.66296948
76MAPK signaling pathway_Homo sapiens_hsa040100.64919090
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.63916163
78VEGF signaling pathway_Homo sapiens_hsa043700.63062270
79Huntingtons disease_Homo sapiens_hsa050160.62866374
80Pentose phosphate pathway_Homo sapiens_hsa000300.62492986
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62377395
82Focal adhesion_Homo sapiens_hsa045100.61970947
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61592279
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61234645
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61106644
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60977013
87Fatty acid elongation_Homo sapiens_hsa000620.59749197
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58587808
89Thyroid hormone synthesis_Homo sapiens_hsa049180.58322684
90Carbon metabolism_Homo sapiens_hsa012000.56615838
91Fructose and mannose metabolism_Homo sapiens_hsa000510.55048236
92Adherens junction_Homo sapiens_hsa045200.52880912
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52553473
94Hedgehog signaling pathway_Homo sapiens_hsa043400.51370674
95Choline metabolism in cancer_Homo sapiens_hsa052310.50973400
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50528599
97mTOR signaling pathway_Homo sapiens_hsa041500.50133356
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48386192
99Rap1 signaling pathway_Homo sapiens_hsa040150.47027828
100Basal cell carcinoma_Homo sapiens_hsa052170.46003963
101Tight junction_Homo sapiens_hsa045300.45392738
102Histidine metabolism_Homo sapiens_hsa003400.45088827
103HIF-1 signaling pathway_Homo sapiens_hsa040660.44169042
104PPAR signaling pathway_Homo sapiens_hsa033200.43770537
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.43641116
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43470145
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43343391
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43148739
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41916042
110Vitamin B6 metabolism_Homo sapiens_hsa007500.41859450
111Ras signaling pathway_Homo sapiens_hsa040140.41253181
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40992194
113Propanoate metabolism_Homo sapiens_hsa006400.40730901
114Pyruvate metabolism_Homo sapiens_hsa006200.39655037
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.39545769
116Phototransduction_Homo sapiens_hsa047440.39189238
117ECM-receptor interaction_Homo sapiens_hsa045120.39131501
118Inositol phosphate metabolism_Homo sapiens_hsa005620.37642054
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.37300406
120Bile secretion_Homo sapiens_hsa049760.36464988
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35039878
122Insulin resistance_Homo sapiens_hsa049310.34523695
123Renal cell carcinoma_Homo sapiens_hsa052110.31315849
124Wnt signaling pathway_Homo sapiens_hsa043100.30979757
125AMPK signaling pathway_Homo sapiens_hsa041520.30779838
126Arginine biosynthesis_Homo sapiens_hsa002200.29853287
127Non-small cell lung cancer_Homo sapiens_hsa052230.29587369
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.28886500

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