CAP2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cAMP catabolic process (GO:0006198)5.82678488
2cyclic nucleotide catabolic process (GO:0009214)5.17781570
3CENP-A containing nucleosome assembly (GO:0034080)5.05169674
4mitotic sister chromatid cohesion (GO:0007064)4.98866587
5enteric nervous system development (GO:0048484)4.82128658
6monoubiquitinated protein deubiquitination (GO:0035520)4.73247690
7mitotic G2/M transition checkpoint (GO:0044818)4.72956054
8chromatin remodeling at centromere (GO:0031055)4.71875465
9mitotic G2 DNA damage checkpoint (GO:0007095)4.62954019
10histone mRNA catabolic process (GO:0071044)4.61566125
11pre-miRNA processing (GO:0031054)4.41455568
12negative regulation of DNA repair (GO:0045738)4.25841393
13histone exchange (GO:0043486)4.24997766
14regulation of DNA endoreduplication (GO:0032875)4.22006936
15establishment of protein localization to Golgi (GO:0072600)4.15204258
16DNA replication-independent nucleosome assembly (GO:0006336)4.04500532
17DNA replication-independent nucleosome organization (GO:0034724)4.04500532
18negative regulation of DNA-dependent DNA replication (GO:2000104)4.01932368
19attachment of spindle microtubules to kinetochore (GO:0008608)4.01794334
20kinetochore organization (GO:0051383)3.96617905
21protein targeting to Golgi (GO:0000042)3.93317312
22nuclear pore complex assembly (GO:0051292)3.78125442
23negative regulation of neurotransmitter transport (GO:0051589)3.75836403
24microtubule anchoring (GO:0034453)3.72946522
25retrograde transport, vesicle recycling within Golgi (GO:0000301)3.70188431
26histone mRNA metabolic process (GO:0008334)3.63512077
27positive regulation of developmental pigmentation (GO:0048087)3.61874863
28protein K48-linked deubiquitination (GO:0071108)3.58519696
29interkinetic nuclear migration (GO:0022027)3.55533425
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.48832226
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38414973
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.38414973
33regulation of translation, ncRNA-mediated (GO:0045974)3.38414973
34microtubule depolymerization (GO:0007019)3.34624589
35positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.34237055
36regulation of pigment cell differentiation (GO:0050932)3.27930704
37kinetochore assembly (GO:0051382)3.27168745
38regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.26568906
39positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.26568906
40positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.25457416
41negative regulation of fibroblast apoptotic process (GO:2000270)3.20789592
42meiotic chromosome segregation (GO:0045132)3.17514601
43cGMP metabolic process (GO:0046068)3.14473695
44histone-serine phosphorylation (GO:0035404)3.04542800
45genitalia morphogenesis (GO:0035112)3.04224123
46negative regulation of digestive system process (GO:0060457)3.02761427
47oocyte maturation (GO:0001556)3.02621828
48centrosome localization (GO:0051642)2.97337050
49histone H3-K36 demethylation (GO:0070544)2.95234210
50mitotic DNA integrity checkpoint (GO:0044774)2.94867308
51protein localization to kinetochore (GO:0034501)2.94186966
52regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.93910721
53positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.93910721
54regulation of protein polyubiquitination (GO:1902914)2.93752548
55N-terminal protein amino acid acetylation (GO:0006474)2.92431814
56regulation of fibroblast apoptotic process (GO:2000269)2.91802670
57detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.87227236
58fat-soluble vitamin catabolic process (GO:0042363)2.84719095
59vitamin catabolic process (GO:0009111)2.84719095
60sister chromatid cohesion (GO:0007062)2.79912808
61cAMP metabolic process (GO:0046058)2.78845659
62resolution of meiotic recombination intermediates (GO:0000712)2.77416423
63regulation of mRNA 3-end processing (GO:0031440)2.73057488
64histone H2A ubiquitination (GO:0033522)2.72602216
65protein K11-linked deubiquitination (GO:0035871)2.72430934
66NLS-bearing protein import into nucleus (GO:0006607)2.72062019
67pore complex assembly (GO:0046931)2.69991412
68protein localization to chromosome, centromeric region (GO:0071459)2.68061880
69microglial cell activation (GO:0001774)2.67974385
70V(D)J recombination (GO:0033151)2.67678013
71response to X-ray (GO:0010165)2.67050076
72regulation of chromatin silencing (GO:0031935)2.67028107
73histone H3-K9 demethylation (GO:0033169)2.66962311
74cell proliferation in forebrain (GO:0021846)2.66703611
75DNA topological change (GO:0006265)2.66487809
76regulation of penile erection (GO:0060405)2.65665759
77negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.65505509
78negative regulation of neurotransmitter secretion (GO:0046929)2.63525658
79sister chromatid segregation (GO:0000819)2.62970138
80negative regulation of smooth muscle cell differentiation (GO:0051151)2.62146723
81response to hydroperoxide (GO:0033194)2.62013209
82ether lipid metabolic process (GO:0046485)2.61970383
83positive regulation of mRNA 3-end processing (GO:0031442)2.58023116
84primitive streak formation (GO:0090009)2.57321003
85positive regulation of mRNA catabolic process (GO:0061014)2.56276625
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54667245
87regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54667245
88nuclear pore organization (GO:0006999)2.54652691
89positive regulation of mRNA processing (GO:0050685)2.53281153
90negative regulation of cell cycle G2/M phase transition (GO:1902750)2.53247464
91replicative senescence (GO:0090399)2.52925331
92protein localization to microtubule cytoskeleton (GO:0072698)2.51642971
93neuronal stem cell maintenance (GO:0097150)2.50094009
94mitotic DNA damage checkpoint (GO:0044773)2.49469834
95regulation of establishment of cell polarity (GO:2000114)2.49190504
96oogenesis (GO:0048477)2.49184963
97positive regulation of gamma-delta T cell activation (GO:0046645)2.48739634
98mitotic chromosome condensation (GO:0007076)2.48005722
99radial glial cell differentiation (GO:0060019)2.47139310
100lipid translocation (GO:0034204)2.43234279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.12900165
2GATA1_22025678_ChIP-Seq_K562_Human4.91201543
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.41909218
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14383597
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.97345205
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85788334
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.64605111
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62713573
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40228472
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36286428
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27111734
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.21721373
13E2F7_22180533_ChIP-Seq_HELA_Human2.16453387
14GBX2_23144817_ChIP-Seq_PC3_Human2.11432888
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05423065
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.95553654
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93640611
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90042209
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87922597
20EWS_26573619_Chip-Seq_HEK293_Human1.77202851
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76254348
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76254348
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76254348
24TAF15_26573619_Chip-Seq_HEK293_Human1.75180242
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74180020
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68062110
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68062110
28P300_19829295_ChIP-Seq_ESCs_Human1.66471753
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57241820
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.56292589
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55364026
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55350011
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.54102963
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54078693
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49598745
36GF1_26923725_Chip-Seq_HPCs_Mouse1.49002137
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46339017
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44278768
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42860468
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42090861
41IGF1R_20145208_ChIP-Seq_DFB_Human1.37558521
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35046636
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34254859
44FUS_26573619_Chip-Seq_HEK293_Human1.32546079
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32505983
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32316868
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30175842
48EZH2_22144423_ChIP-Seq_EOC_Human1.28910760
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27593282
50SMAD4_21799915_ChIP-Seq_A2780_Human1.27350401
51STAT3_23295773_ChIP-Seq_U87_Human1.26697603
52AR_21572438_ChIP-Seq_LNCaP_Human1.26261585
53SCL_19346495_ChIP-Seq_HPC-7_Human1.24496896
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.24190821
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23436217
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.22008465
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19902686
58KDM2B_26808549_Chip-Seq_REH_Human1.18270283
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.17045940
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16478867
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15821751
62AR_21909140_ChIP-Seq_LNCAP_Human1.15722810
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15683370
64RUNX_20019798_ChIP-Seq_JUKART_Human1.14478036
65VDR_24787735_ChIP-Seq_THP-1_Human1.14185350
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14110682
67TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13962782
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10936492
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09459378
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.08731851
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08257336
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05262871
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04346609
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03721869
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03138281
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.01427481
77GF1B_26923725_Chip-Seq_HPCs_Mouse1.00349135
78ELK1_19687146_ChIP-ChIP_HELA_Human1.00126272
79IRF8_27001747_Chip-Seq_BMDM_Mouse0.99755539
80NANOG_18555785_Chip-Seq_ESCs_Mouse0.99321161
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.98825601
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98567176
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98494391
84TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98014454
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97824762
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97106934
87CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96985318
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96945878
89TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96483628
90TCF4_23295773_ChIP-Seq_U87_Human0.95932374
91BRD4_25478319_ChIP-Seq_HGPS_Human0.95767292
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95257537
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95139975
94CBP_20019798_ChIP-Seq_JUKART_Human0.92680447
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92680447
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92162463
97AR_25329375_ChIP-Seq_VCAP_Human0.91064374
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90791507
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90072446
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88056625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.58670467
2MP0003136_yellow_coat_color5.57871979
3MP0008057_abnormal_DNA_replication4.14423513
4MP0003183_abnormal_peptide_metabolism3.52227030
5MP0003828_pulmonary_edema3.25706750
6MP0005174_abnormal_tail_pigmentation3.20251248
7MP0006292_abnormal_olfactory_placode2.48853391
8MP0002254_reproductive_system_inflammat2.40003909
9MP0003941_abnormal_skin_development2.39597663
10MP0004381_abnormal_hair_follicle2.38110423
11MP0006054_spinal_hemorrhage2.22749805
12MP0003890_abnormal_embryonic-extraembry2.18060920
13MP0004883_abnormal_blood_vessel2.07849732
14MP0002163_abnormal_gland_morphology2.04669770
15MP0002751_abnormal_autonomic_nervous2.00525211
16MP0009379_abnormal_foot_pigmentation1.96533522
17MP0001188_hyperpigmentation1.95936536
18MP0003011_delayed_dark_adaptation1.88704861
19MP0005075_abnormal_melanosome_morpholog1.88004776
20MP0000015_abnormal_ear_pigmentation1.87592917
21MP0010094_abnormal_chromosome_stability1.86401621
22MP0002160_abnormal_reproductive_system1.84713436
23MP0003077_abnormal_cell_cycle1.78575933
24MP0000371_diluted_coat_color1.65386130
25MP0002095_abnormal_skin_pigmentation1.61625404
26MP0002090_abnormal_vision1.59347183
27MP0008007_abnormal_cellular_replicative1.58567622
28MP0005248_abnormal_Harderian_gland1.57415625
29MP0000383_abnormal_hair_follicle1.49452301
30MP0008877_abnormal_DNA_methylation1.48580150
31MP0003195_calcinosis1.47115216
32MP0001666_abnormal_nutrient_absorption1.42273504
33MP0005076_abnormal_cell_differentiation1.32821222
34MP0009697_abnormal_copulation1.31831933
35MP0005389_reproductive_system_phenotype1.20993365
36MP0001286_abnormal_eye_development1.20949803
37MP0002396_abnormal_hematopoietic_system1.18450746
38MP0003950_abnormal_plasma_membrane1.16505039
39MP0003111_abnormal_nucleus_morphology1.15900511
40MP0010352_gastrointestinal_tract_polyps1.13164681
41MP0010678_abnormal_skin_adnexa1.10335785
42MP0002295_abnormal_pulmonary_circulatio1.09084667
43MP0001853_heart_inflammation1.09012813
44MP0008058_abnormal_DNA_repair1.07319025
45MP0004185_abnormal_adipocyte_glucose1.06147362
46MP0003763_abnormal_thymus_physiology1.06036829
47MP0003632_abnormal_nervous_system1.05703619
48MP0003656_abnormal_erythrocyte_physiolo1.03277060
49MP0003868_abnormal_feces_composition0.97600011
50MP0002928_abnormal_bile_duct0.96246373
51MP0005220_abnormal_exocrine_pancreas0.94509135
52MP0000647_abnormal_sebaceous_gland0.90952264
53MP0005164_abnormal_response_to0.90169444
54MP0008260_abnormal_autophagy0.89359315
55MP0002075_abnormal_coat/hair_pigmentati0.88767858
56MP0005379_endocrine/exocrine_gland_phen0.86853501
57MP0001119_abnormal_female_reproductive0.86509704
58MP0003937_abnormal_limbs/digits/tail_de0.85325779
59MP0002127_abnormal_cardiovascular_syste0.85084761
60MP0002277_abnormal_respiratory_mucosa0.80248512
61MP0001293_anophthalmia0.80248511
62MP0001800_abnormal_humoral_immune0.74248432
63MP0004484_altered_response_of0.73581335
64MP0002398_abnormal_bone_marrow0.73508301
65MP0005377_hearing/vestibular/ear_phenot0.73238845
66MP0003878_abnormal_ear_physiology0.73238845
67MP0003984_embryonic_growth_retardation0.73044214
68MP0002088_abnormal_embryonic_growth/wei0.72942188
69MP0001186_pigmentation_phenotype0.72892896
70MP0000703_abnormal_thymus_morphology0.71499870
71MP0001529_abnormal_vocalization0.70762646
72MP0003303_peritoneal_inflammation0.70618589
73MP0008932_abnormal_embryonic_tissue0.70406303
74MP0005464_abnormal_platelet_physiology0.69803528
75MP0003724_increased_susceptibility_to0.68366167
76MP0002133_abnormal_respiratory_system0.66960441
77MP0005388_respiratory_system_phenotype0.66960441
78MP0001672_abnormal_embryogenesis/_devel0.66772180
79MP0005380_embryogenesis_phenotype0.66772180
80MP0001929_abnormal_gametogenesis0.66562284
81MP0000428_abnormal_craniofacial_morphol0.66515815
82MP0009703_decreased_birth_body0.66380563
83MP0001915_intracranial_hemorrhage0.64946180
84MP0003221_abnormal_cardiomyocyte_apopto0.64664018
85MP0000432_abnormal_head_morphology0.64253557
86MP0010030_abnormal_orbit_morphology0.64041489
87MP0002332_abnormal_exercise_endurance0.63662628
88MP0002006_tumorigenesis0.63280929
89MP0010307_abnormal_tumor_latency0.63145980
90MP0001851_eye_inflammation0.62727155
91MP0003935_abnormal_craniofacial_develop0.62501859
92MP0003252_abnormal_bile_duct0.61776174
93MP0002210_abnormal_sex_determination0.61438380
94MP0005409_darkened_coat_color0.61063738
95MP0002009_preneoplasia0.61043900
96MP0009115_abnormal_fat_cell0.60965839
97MP0002697_abnormal_eye_size0.59991976
98MP0002177_abnormal_outer_ear0.59629632
99MP0004808_abnormal_hematopoietic_stem0.59546605
100MP0002109_abnormal_limb_morphology0.58800789

Predicted human phenotypes

RankGene SetZ-score
1Truncal obesity (HP:0001956)4.74826976
2Agitation (HP:0000713)4.61992906
3Striae distensae (HP:0001065)4.02592279
4Volvulus (HP:0002580)4.00057989
5Carpal bone hypoplasia (HP:0001498)3.84795801
6Long clavicles (HP:0000890)3.77144253
7Genetic anticipation (HP:0003743)3.72170822
8Bilateral microphthalmos (HP:0007633)3.36392571
9Thoracolumbar scoliosis (HP:0002944)3.22379189
10Vertebral arch anomaly (HP:0008438)3.18595373
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.13618146
12Hypoplastic iliac wings (HP:0002866)3.06462360
13Diastasis recti (HP:0001540)2.99542512
14T lymphocytopenia (HP:0005403)2.94345203
15Abnormality of the labia majora (HP:0012881)2.94180784
16Lack of skin elasticity (HP:0100679)2.91141722
17Restlessness (HP:0000711)2.82649202
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62171750
1911 pairs of ribs (HP:0000878)2.54592786
20Short middle phalanx of the 5th finger (HP:0004220)2.48456539
21Abnormality of the parietal bone (HP:0002696)2.45101941
22Broad ribs (HP:0000885)2.40497322
23Abnormal number of incisors (HP:0011064)2.38130133
24Thyroid-stimulating hormone excess (HP:0002925)2.37031811
25Submucous cleft hard palate (HP:0000176)2.36577489
26Abnormal auditory evoked potentials (HP:0006958)2.36278539
27Abnormality of T cell number (HP:0011839)2.33471478
28Abnormality of the axillary hair (HP:0100134)2.31888296
29Abnormality of secondary sexual hair (HP:0009888)2.31888296
30Abnormality of chromosome stability (HP:0003220)2.31436469
31Hypoplastic labia majora (HP:0000059)2.31400193
32Chronic mucocutaneous candidiasis (HP:0002728)2.29409898
33Recurrent cutaneous fungal infections (HP:0011370)2.29409898
34Uterine leiomyosarcoma (HP:0002891)2.28441505
35Leiomyosarcoma (HP:0100243)2.28441505
36Albinism (HP:0001022)2.28330384
37Transitional cell carcinoma of the bladder (HP:0006740)2.26015891
38Hypercortisolism (HP:0001578)2.25536029
39Neoplasm of the tracheobronchial system (HP:0100552)2.21381492
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20873637
41Long eyelashes (HP:0000527)2.20637396
42Missing ribs (HP:0000921)2.19242154
43Colon cancer (HP:0003003)2.18416492
44Abnormality of the columella (HP:0009929)2.15731925
45Chromsome breakage (HP:0040012)2.13590136
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.13201025
47Facial diplegia (HP:0001349)2.11266300
48Progressive cerebellar ataxia (HP:0002073)2.09825386
49Hypoplastic nipples (HP:0002557)2.09767435
50Small hand (HP:0200055)2.09589033
51Thin bony cortex (HP:0002753)2.06900786
52Thickened calvaria (HP:0002684)2.06653112
53Abnormality of the wing of the ilium (HP:0011867)2.06520314
54Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.05417423
55Syringomyelia (HP:0003396)2.04613889
56Spinal cord lesions (HP:0100561)2.04613889
57Bladder neoplasm (HP:0009725)2.03428432
58Bladder carcinoma (HP:0002862)2.03428432
59Rhabdomyosarcoma (HP:0002859)2.02197513
60Nephroblastoma (Wilms tumor) (HP:0002667)1.99771064
61Clubbing of toes (HP:0100760)1.95933954
62Increased number of teeth (HP:0011069)1.95837230
63Abnormality of incisor morphology (HP:0011063)1.93332287
64Ectopic kidney (HP:0000086)1.93014412
65Tubulointerstitial nephritis (HP:0001970)1.92856620
66Acute myeloid leukemia (HP:0004808)1.92025794
67Acute lymphatic leukemia (HP:0006721)1.89983657
68Large earlobe (HP:0009748)1.89051331
69Embryonal renal neoplasm (HP:0011794)1.84429562
70Abnormality of the fingertips (HP:0001211)1.82336956
71Hypoplastic ilia (HP:0000946)1.80422894
72Dislocated radial head (HP:0003083)1.78848321
73Bifid tongue (HP:0010297)1.78685204
74Oligodactyly (hands) (HP:0001180)1.77481129
75Barrel-shaped chest (HP:0001552)1.77384049
76Papillary thyroid carcinoma (HP:0002895)1.77144765
77Short middle phalanx of finger (HP:0005819)1.76810286
78Myocardial infarction (HP:0001658)1.76475924
79Ankyloglossia (HP:0010296)1.76208374
80Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.75518080
81Abnormality of the epiphyses of the hand (HP:0005924)1.74800280
82Abnormality of the incisor (HP:0000676)1.73589571
83Hypoplastic pelvis (HP:0008839)1.73137184
84Hypochromic microcytic anemia (HP:0004840)1.71816682
85Malignant gastrointestinal tract tumors (HP:0006749)1.71280541
86Gastrointestinal carcinoma (HP:0002672)1.71280541
87Delayed epiphyseal ossification (HP:0002663)1.71214365
88Popliteal pterygium (HP:0009756)1.70168465
89Round face (HP:0000311)1.69748422
90Mesomelia (HP:0003027)1.69683159
91Type I diabetes mellitus (HP:0100651)1.69059438
92Aortic aneurysm (HP:0004942)1.67982778
93Neoplasm of striated muscle (HP:0009728)1.67587512
94Narrow palate (HP:0000189)1.65841080
95Concave nail (HP:0001598)1.64733957
96Rib fusion (HP:0000902)1.64617104
97Ectropion (HP:0000656)1.64390487
98Sandal gap (HP:0001852)1.64386189
99Hepatoblastoma (HP:0002884)1.61937552
100Congenital, generalized hypertrichosis (HP:0004540)1.61206468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.60402168
2FRK3.19605561
3WEE13.14313346
4AKT32.84755795
5IRAK12.73672448
6CDC72.68846562
7ACVR1B2.52501437
8IRAK22.32807863
9CDK122.23582129
10EIF2AK32.19967062
11MAP3K62.05089290
12MKNK22.02000732
13NEK11.95805291
14TGFBR21.89761485
15EIF2AK21.75979212
16MAP2K31.61092919
17MKNK11.61044554
18MAP2K41.60964054
19EPHA41.59438906
20BRSK21.51891296
21CAMK1G1.50491590
22NLK1.48681489
23PIK3CG1.42257260
24TXK1.42125302
25VRK21.38779406
26GRK71.37932046
27NEK91.36374472
28SGK21.33625731
29TEC1.32558225
30NEK21.32305149
31BRD41.32116056
32TAF11.29594799
33IRAK41.27648745
34GRK51.23969452
35NUAK11.19526701
36MELK1.17957112
37MAP3K21.17317877
38BLK1.14581151
39ERBB21.14549271
40TAOK31.12064829
41CAMK1D1.11026140
42STK161.10171327
43CDK81.05427160
44CDK191.04402623
45WNK11.02235082
46PLK31.01515481
47ZAK0.95078410
48TTK0.93491513
49MST1R0.92619408
50DYRK1A0.84637327
51STK100.84128922
52IKBKE0.82693959
53PLK20.81125533
54MARK30.77869046
55MAP4K10.75003582
56PLK40.72750279
57CHEK20.71699584
58FGR0.71587388
59YES10.71137511
60MATK0.70691569
61SGK10.70535839
62SGK4940.68486871
63SGK2230.68486871
64KIT0.68367454
65FGFR30.67399321
66CAMK40.66796910
67SGK30.65318867
68BRAF0.64293685
69PLK10.63184561
70MAP4K20.60652040
71BUB10.59563215
72CDK60.59397470
73MOS0.58768659
74OXSR10.56837225
75TYK20.55216459
76TRIM280.54148973
77CDK40.53500798
78CHEK10.53441719
79SYK0.52308876
80VRK10.50965218
81MAP3K40.49880508
82NTRK20.48956620
83DYRK30.48515230
84MAP3K140.47753235
85OBSCN0.46978273
86BTK0.46747191
87AURKB0.45057584
88CSK0.42781811
89JAK10.41002005
90MAP3K120.39505107
91GRK60.38876229
92PKN20.37200875
93STK40.36971731
94MAP2K60.36152027
95TLK10.34647363
96JAK20.34031652
97PIM10.33963824
98CDK30.32977452
99MAP3K100.32924356
100MAP3K70.32432781

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.57248474
2Mismatch repair_Homo sapiens_hsa034302.50969162
3DNA replication_Homo sapiens_hsa030302.23279017
4p53 signaling pathway_Homo sapiens_hsa041152.10757250
5Homologous recombination_Homo sapiens_hsa034402.05044550
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.88041295
7Fanconi anemia pathway_Homo sapiens_hsa034601.87948121
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69283631
9Prostate cancer_Homo sapiens_hsa052151.66255086
10FoxO signaling pathway_Homo sapiens_hsa040681.59000919
11Systemic lupus erythematosus_Homo sapiens_hsa053221.58570885
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57065610
13Pancreatic cancer_Homo sapiens_hsa052121.53433234
14MicroRNAs in cancer_Homo sapiens_hsa052061.46205814
15Oocyte meiosis_Homo sapiens_hsa041141.44050804
16Ribosome_Homo sapiens_hsa030101.42492466
17Hedgehog signaling pathway_Homo sapiens_hsa043401.36986578
18Base excision repair_Homo sapiens_hsa034101.36608472
19Non-small cell lung cancer_Homo sapiens_hsa052231.35908450
20RNA degradation_Homo sapiens_hsa030181.34292882
21RNA polymerase_Homo sapiens_hsa030201.34008048
22Nucleotide excision repair_Homo sapiens_hsa034201.30277181
23Non-homologous end-joining_Homo sapiens_hsa034501.27289939
24Wnt signaling pathway_Homo sapiens_hsa043101.25116970
25Chronic myeloid leukemia_Homo sapiens_hsa052201.25102857
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24715205
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.24288786
28Acute myeloid leukemia_Homo sapiens_hsa052211.24184764
29Colorectal cancer_Homo sapiens_hsa052101.22724812
30Adherens junction_Homo sapiens_hsa045201.20624766
31Dorso-ventral axis formation_Homo sapiens_hsa043201.16875001
32B cell receptor signaling pathway_Homo sapiens_hsa046621.16010150
33T cell receptor signaling pathway_Homo sapiens_hsa046601.15559879
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14650934
35Small cell lung cancer_Homo sapiens_hsa052221.13615143
36Osteoclast differentiation_Homo sapiens_hsa043801.10418476
37Morphine addiction_Homo sapiens_hsa050321.10314314
38Notch signaling pathway_Homo sapiens_hsa043301.09021507
39TGF-beta signaling pathway_Homo sapiens_hsa043501.08058140
40Viral carcinogenesis_Homo sapiens_hsa052031.04397346
41Basal cell carcinoma_Homo sapiens_hsa052171.03849072
42Thyroid cancer_Homo sapiens_hsa052161.02117441
43ABC transporters_Homo sapiens_hsa020100.99223779
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97538671
45Measles_Homo sapiens_hsa051620.97296594
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.97219703
47Taste transduction_Homo sapiens_hsa047420.96808363
48Renal cell carcinoma_Homo sapiens_hsa052110.95933624
49mRNA surveillance pathway_Homo sapiens_hsa030150.95515085
50Hepatitis B_Homo sapiens_hsa051610.94459009
51Alcoholism_Homo sapiens_hsa050340.94354476
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93272502
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.92198914
54Platelet activation_Homo sapiens_hsa046110.91855184
55HTLV-I infection_Homo sapiens_hsa051660.91047394
56Purine metabolism_Homo sapiens_hsa002300.90855259
57Lysine degradation_Homo sapiens_hsa003100.88944618
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88573433
59Vitamin digestion and absorption_Homo sapiens_hsa049770.87729231
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87151021
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86415904
62Glioma_Homo sapiens_hsa052140.86388247
63Endometrial cancer_Homo sapiens_hsa052130.85535378
64Regulation of autophagy_Homo sapiens_hsa041400.82366203
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79722517
66Prolactin signaling pathway_Homo sapiens_hsa049170.79084828
67Protein export_Homo sapiens_hsa030600.78348557
68Hepatitis C_Homo sapiens_hsa051600.77287403
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77108597
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76346981
71Leishmaniasis_Homo sapiens_hsa051400.76165810
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75907993
73RNA transport_Homo sapiens_hsa030130.75184353
74Epstein-Barr virus infection_Homo sapiens_hsa051690.75026917
75Tuberculosis_Homo sapiens_hsa051520.71487510
76Circadian rhythm_Homo sapiens_hsa047100.70789545
77TNF signaling pathway_Homo sapiens_hsa046680.70717722
78Pathways in cancer_Homo sapiens_hsa052000.69513857
79Inositol phosphate metabolism_Homo sapiens_hsa005620.68496569
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67576419
81Primary immunodeficiency_Homo sapiens_hsa053400.64857415
82Chemokine signaling pathway_Homo sapiens_hsa040620.63975770
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62189135
84Fat digestion and absorption_Homo sapiens_hsa049750.62054777
85Malaria_Homo sapiens_hsa051440.61114584
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60804876
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58321397
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.57960942
89Staphylococcus aureus infection_Homo sapiens_hsa051500.57356356
90Influenza A_Homo sapiens_hsa051640.56112966
91ErbB signaling pathway_Homo sapiens_hsa040120.53892664
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51945472
93Ether lipid metabolism_Homo sapiens_hsa005650.50843330
94Hematopoietic cell lineage_Homo sapiens_hsa046400.50765877
95Spliceosome_Homo sapiens_hsa030400.50050752
96Long-term potentiation_Homo sapiens_hsa047200.48572007
97Melanoma_Homo sapiens_hsa052180.48450075
98Type II diabetes mellitus_Homo sapiens_hsa049300.48367497
99MAPK signaling pathway_Homo sapiens_hsa040100.47999364
100Pyrimidine metabolism_Homo sapiens_hsa002400.47228739

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