CAPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.35924390
2positive regulation by symbiont of host defense response (GO:0052509)5.51182791
3modulation by symbiont of host defense response (GO:0052031)5.51182791
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.51182791
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.51182791
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.51182791
7modulation by symbiont of host immune response (GO:0052553)5.51182791
8neutrophil activation involved in immune response (GO:0002283)5.13761161
9glycosphingolipid catabolic process (GO:0046479)5.08084753
10oligosaccharide catabolic process (GO:0009313)4.72323963
11amino sugar catabolic process (GO:0046348)4.60409435
12glycolipid catabolic process (GO:0019377)4.56417653
13cellular response to thyroid hormone stimulus (GO:0097067)4.53734942
14regulation of interferon-beta biosynthetic process (GO:0045357)4.48933651
15positive regulation of interferon-alpha production (GO:0032727)4.46382393
16immunoglobulin mediated immune response (GO:0016064)4.41652280
17response to peptidoglycan (GO:0032494)4.35285268
18regulation of interferon-alpha production (GO:0032647)4.25337786
19positive regulation of gamma-delta T cell activation (GO:0046645)4.24803502
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19986558
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19986558
22regulation of B cell receptor signaling pathway (GO:0050855)4.15472439
23ceramide catabolic process (GO:0046514)4.09037216
24antigen processing and presentation of endogenous antigen (GO:0019883)4.07576089
25respiratory burst (GO:0045730)4.05839499
26macrophage activation involved in immune response (GO:0002281)4.00352613
27response to thyroid hormone (GO:0097066)3.83166041
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.82050598
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69628122
30response to host immune response (GO:0052572)3.65436572
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.65436572
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64157192
33positive regulation of antigen processing and presentation (GO:0002579)3.62456725
34negative regulation of nitric oxide biosynthetic process (GO:0045019)3.56294633
35positive regulation of mast cell degranulation (GO:0043306)3.52839291
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.52839291
37myeloid cell activation involved in immune response (GO:0002275)3.52273612
38positive regulation of leukocyte degranulation (GO:0043302)3.51149071
39positive regulation of monocyte chemotaxis (GO:0090026)3.50807195
40granulocyte activation (GO:0036230)3.46374682
41type I interferon signaling pathway (GO:0060337)3.46340730
42cellular response to type I interferon (GO:0071357)3.46340730
43response to type I interferon (GO:0034340)3.45247972
44B cell mediated immunity (GO:0019724)3.44393742
45N-acetylneuraminate metabolic process (GO:0006054)3.43151082
46leukocyte aggregation (GO:0070486)3.38534927
47neutrophil activation (GO:0042119)3.38508741
48response to interferon-alpha (GO:0035455)3.34114114
49response to host (GO:0075136)3.30685040
50response to host defenses (GO:0052200)3.30685040
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30685040
52negative regulation of cell killing (GO:0031342)3.30601447
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30601447
54regulation of mast cell activation involved in immune response (GO:0033006)3.28976665
55regulation of leukocyte degranulation (GO:0043300)3.28570436
56positive regulation of interferon-beta production (GO:0032728)3.27925210
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27755404
58membrane lipid catabolic process (GO:0046466)3.27548340
59NIK/NF-kappaB signaling (GO:0038061)3.27312613
60response to muramyl dipeptide (GO:0032495)3.25583329
61positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.25259335
62response to interferon-beta (GO:0035456)3.22924070
63production of molecular mediator involved in inflammatory response (GO:0002532)3.22881186
64sphingolipid catabolic process (GO:0030149)3.22431301
65regulation of macrophage chemotaxis (GO:0010758)3.21415280
66interferon-gamma-mediated signaling pathway (GO:0060333)3.20963292
67T-helper 1 type immune response (GO:0042088)3.20803642
68regulation of cholesterol storage (GO:0010885)3.20643327
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20472883
70regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.17166058
71defense response to protozoan (GO:0042832)3.16272227
72regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16143363
73regulation of superoxide anion generation (GO:0032928)3.15536530
74natural killer cell mediated cytotoxicity (GO:0042267)3.15117886
75natural killer cell mediated immunity (GO:0002228)3.15117886
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15054993
77regulation of antigen processing and presentation (GO:0002577)3.12867496
78cellular response to zinc ion (GO:0071294)3.11873572
79positive regulation of chemokine biosynthetic process (GO:0045080)3.08776326
80detection of other organism (GO:0098543)3.07853287
81antigen processing and presentation via MHC class Ib (GO:0002475)3.07506018
82positive regulation of mast cell activation (GO:0033005)3.06455442
83regulation of interleukin-12 biosynthetic process (GO:0045075)3.04663216
84macrophage differentiation (GO:0030225)3.04263192
85myeloid dendritic cell differentiation (GO:0043011)3.01784580
86cellular response to interferon-beta (GO:0035458)3.01529548
87regulation of vitamin D biosynthetic process (GO:0060556)3.01097238
88T cell migration (GO:0072678)3.00138578
89myeloid dendritic cell activation (GO:0001773)2.98626342
90regulation of gamma-delta T cell activation (GO:0046643)2.98319581
91hydrogen peroxide biosynthetic process (GO:0050665)2.97308623
92regulation of podosome assembly (GO:0071801)2.94333306
93pinocytosis (GO:0006907)2.94221097
94regulation of B cell differentiation (GO:0045577)2.93507492
95response to protozoan (GO:0001562)2.93445697
96regulation of gamma-delta T cell differentiation (GO:0045586)2.92870605
97detection of external biotic stimulus (GO:0098581)2.90405555
98phagosome maturation (GO:0090382)2.88923487
99eosinophil chemotaxis (GO:0048245)2.87780156
100detection of bacterium (GO:0016045)2.87252092
101leukocyte cell-cell adhesion (GO:0007159)2.87003338
102positive regulation of B cell differentiation (GO:0045579)2.86647500
103protein localization to endosome (GO:0036010)2.86403123
104negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85199487
105regulation of mast cell activation (GO:0033003)2.85183752
106regulation of monocyte chemotaxis (GO:0090025)2.84319342
107regulation of mononuclear cell migration (GO:0071675)2.83860987
108B cell receptor signaling pathway (GO:0050853)2.83219440
109actin nucleation (GO:0045010)2.82048319
110superoxide anion generation (GO:0042554)2.81635512
111regulation of mast cell degranulation (GO:0043304)2.79567946
112regulation of interleukin-8 biosynthetic process (GO:0045414)2.78881963
113microglial cell activation (GO:0001774)2.78657842
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77996698
115regulation of T-helper 1 cell differentiation (GO:0045625)2.77655266
116negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.76794828
117apoptotic cell clearance (GO:0043277)2.76153087
118negative regulation of myeloid cell apoptotic process (GO:0033033)2.75050629
119sequestering of actin monomers (GO:0042989)2.74849140
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.74712670
121dendritic cell differentiation (GO:0097028)2.74313890
122positive regulation of cholesterol efflux (GO:0010875)2.74145988
123macrophage activation (GO:0042116)2.74049744
124mast cell activation (GO:0045576)2.73778205
125myeloid leukocyte activation (GO:0002274)2.73611572
126cellular extravasation (GO:0045123)2.73431748
127positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73063890
128positive regulation of cellular amide metabolic process (GO:0034250)2.72777672
129regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72076525
130cellular response to interferon-alpha (GO:0035457)2.71059499
131monocyte chemotaxis (GO:0002548)2.69285772
132negative regulation of cytokine production involved in immune response (GO:0002719)2.68995648
133positive regulation of natural killer cell differentiation (GO:0032825)2.68600537
134lymphocyte chemotaxis (GO:0048247)2.67415250
135regulation of hypersensitivity (GO:0002883)2.66854141
136negative regulation of interleukin-12 production (GO:0032695)2.66751974
137regulation of chemokine biosynthetic process (GO:0045073)2.66619083
138positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.66039712
139regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.66030698
140peptide catabolic process (GO:0043171)2.65736416
141leukocyte degranulation (GO:0043299)2.65314454
142positive regulation of macrophage differentiation (GO:0045651)2.63751160
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63450995
144negative regulation of viral genome replication (GO:0045071)2.63376960
145positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63179110
146mature B cell differentiation involved in immune response (GO:0002313)2.62350015
147detection of molecule of bacterial origin (GO:0032490)2.62151651
148positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.62091583
149cellular response to interferon-gamma (GO:0071346)2.60431118
150eosinophil migration (GO:0072677)2.58448425
151negative regulation of erythrocyte differentiation (GO:0045647)2.56814708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.88349772
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.81400628
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.14444751
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69164157
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.56913177
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41164341
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33612455
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26621998
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25920055
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22334958
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89782296
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89429861
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80849378
14* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.66713843
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.64783530
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.59397358
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46165218
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44426705
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40684091
20SPI1_23547873_ChIP-Seq_NB4_Human2.37005716
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31955981
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.31165350
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24678627
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18323206
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10684169
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09210229
27* RUNX1_22412390_ChIP-Seq_EML_Mouse1.95116279
28VDR_21846776_ChIP-Seq_THP-1_Human1.93707865
29* MYB_26560356_Chip-Seq_TH2_Human1.90604186
30VDR_24763502_ChIP-Seq_THP-1_Human1.90559766
31MAF_26560356_Chip-Seq_TH1_Human1.90541096
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85182730
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82710721
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72643632
35SCL_19346495_ChIP-Seq_HPC-7_Human1.71935365
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66057660
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63482931
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60318701
39MYB_26560356_Chip-Seq_TH1_Human1.59453296
40SPI1_23127762_ChIP-Seq_K562_Human1.55847883
41MYC_22102868_ChIP-Seq_BL_Human1.55760769
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54664759
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51193001
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50497201
45PU_27001747_Chip-Seq_BMDM_Mouse1.50343844
46* RUNX_20019798_ChIP-Seq_JUKART_Human1.48053788
47* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46556580
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.46467514
49* UTX_26944678_Chip-Seq_JUKART_Human1.46388596
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40110209
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39514858
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36303832
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34822947
54E2F7_22180533_ChIP-Seq_HELA_Human1.34201349
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32736983
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32320571
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31857147
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31409182
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28692718
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28041255
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27578965
62TFEB_21752829_ChIP-Seq_HELA_Human1.26980178
63TCF7_22412390_ChIP-Seq_EML_Mouse1.22500725
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21637771
65* BCL6_27268052_Chip-Seq_Bcells_Human1.21369275
66MAF_26560356_Chip-Seq_TH2_Human1.19448597
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.18201122
68* BCOR_27268052_Chip-Seq_Bcells_Human1.18084954
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16140877
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15096821
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13677914
72* GATA3_27048872_Chip-Seq_THYMUS_Human1.13566919
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12589225
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09994525
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09756649
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09521650
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.09014700
78RACK7_27058665_Chip-Seq_MCF-7_Human1.07960310
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07828640
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07505824
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07483197
82VDR_24787735_ChIP-Seq_THP-1_Human1.06942896
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.05899005
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05630072
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05622694
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05347721
87STAT1_20625510_ChIP-Seq_HELA_Human1.05267282
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05215710
89GATA3_26560356_Chip-Seq_TH2_Human1.03266671
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01904655
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96913978
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95958624
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95279683
94GATA1_22025678_ChIP-Seq_K562_Human0.94239905
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94169494
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94028404
97GATA1_19941826_ChIP-Seq_K562_Human0.93801199
98PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93222574
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93147648
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.92308334
101* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92108550
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91295202
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88998056
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88998056
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88613113
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88325987
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88077633
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87653161
109* LXR_22292898_ChIP-Seq_THP-1_Human0.86851718
110* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84910350
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84665179
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83977587
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81442798
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78469769
115* KDM2B_26808549_Chip-Seq_DND41_Human0.77732593
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77573884
117SPI1_20517297_ChIP-Seq_HL60_Human0.76366045
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75050123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.15355714
2MP0003436_decreased_susceptibility_to3.75293354
3MP0009785_altered_susceptibility_to3.43144731
4MP0003303_peritoneal_inflammation3.21443527
5MP0005000_abnormal_immune_tolerance3.05234441
6MP0006082_CNS_inflammation2.99945040
7MP0002148_abnormal_hypersensitivity_rea2.98853509
8MP0005058_abnormal_lysosome_morphology2.94383368
9* MP0002419_abnormal_innate_immunity2.90732869
10MP0000685_abnormal_immune_system2.89036083
11* MP0005025_abnormal_response_to2.77298759
12MP0001790_abnormal_immune_system2.72079717
13MP0005387_immune_system_phenotype2.72079717
14MP0005671_abnormal_response_to2.65092471
15* MP0002452_abnormal_antigen_presenting2.63272111
16MP0001800_abnormal_humoral_immune2.54835094
17MP0003724_increased_susceptibility_to2.50234156
18MP0002723_abnormal_immune_serum2.45681065
19* MP0001819_abnormal_immune_cell2.29920083
20* MP0002420_abnormal_adaptive_immunity2.28929320
21MP0004510_myositis2.28164781
22MP0003806_abnormal_nucleotide_metabolis2.18182766
23MP0005464_abnormal_platelet_physiology2.14446443
24MP0004947_skin_inflammation2.13211403
25MP0003172_abnormal_lysosome_physiology2.11956216
26MP0002405_respiratory_system_inflammati2.09399125
27MP0001533_abnormal_skeleton_physiology2.07800916
28MP0001853_heart_inflammation1.94565928
29MP0002139_abnormal_hepatobiliary_system1.92310842
30MP0001845_abnormal_inflammatory_respons1.83198142
31MP0010155_abnormal_intestine_physiology1.77182195
32MP0009333_abnormal_splenocyte_physiolog1.76299244
33MP0000343_altered_response_to1.75553040
34MP0002398_abnormal_bone_marrow1.74194027
35MP0000716_abnormal_immune_system1.73651694
36MP0003448_altered_tumor_morphology1.73427383
37MP0005451_abnormal_body_composition1.66339312
38MP0002933_joint_inflammation1.64777547
39MP0003300_gastrointestinal_ulcer1.57251115
40MP0000689_abnormal_spleen_morphology1.55947355
41MP0002006_tumorigenesis1.55377015
42MP0000858_altered_metastatic_potential1.55212877
43MP0002166_altered_tumor_susceptibility1.53735732
44MP0008469_abnormal_protein_level1.49532435
45MP0008438_abnormal_cutaneous_collagen1.47146050
46MP0002429_abnormal_blood_cell1.46159038
47MP0002722_abnormal_immune_system1.45710469
48MP0002998_abnormal_bone_remodeling1.42617677
49MP0005310_abnormal_salivary_gland1.42149756
50MP0001545_abnormal_hematopoietic_system1.41446054
51MP0005397_hematopoietic_system_phenotyp1.41446054
52MP0008260_abnormal_autophagy1.40806281
53MP0003329_amyloid_beta_deposits1.40027807
54MP0003191_abnormal_cellular_cholesterol1.39542008
55MP0003763_abnormal_thymus_physiology1.38729585
56MP0003566_abnormal_cell_adhesion1.38468286
57MP0009278_abnormal_bone_marrow1.36959745
58MP0009764_decreased_sensitivity_to1.33754797
59MP0009840_abnormal_foam_cell1.30761761
60MP0001851_eye_inflammation1.28853772
61MP0001873_stomach_inflammation1.24086253
62MP0010307_abnormal_tumor_latency1.22480858
63MP0000465_gastrointestinal_hemorrhage1.21947530
64MP0003075_altered_response_to1.20923577
65MP0005257_abnormal_intraocular_pressure1.20156982
66MP0005174_abnormal_tail_pigmentation1.15229059
67MP0004808_abnormal_hematopoietic_stem1.12367635
68MP0003705_abnormal_hypodermis_morpholog1.11047884
69MP0000604_amyloidosis1.10187737
70MP0005390_skeleton_phenotype1.09977244
71MP0005165_increased_susceptibility_to1.09805725
72MP0005023_abnormal_wound_healing1.09019746
73MP0005166_decreased_susceptibility_to1.08693169
74MP0000490_abnormal_crypts_of1.07298703
75MP0001958_emphysema1.07067479
76MP0002396_abnormal_hematopoietic_system1.02866213
77MP0000920_abnormal_myelination1.00093812
78MP0010352_gastrointestinal_tract_polyps0.96154709
79MP0005365_abnormal_bile_salt0.90742999
80MP0003828_pulmonary_edema0.90487545
81MP0003453_abnormal_keratinocyte_physiol0.89830522
82MP0003186_abnormal_redox_activity0.88759899
83MP0000703_abnormal_thymus_morphology0.87954698
84MP0003866_abnormal_defecation0.87040023
85MP0004883_abnormal_blood_vessel0.86817366
86MP0003795_abnormal_bone_structure0.86083864
87MP0001542_abnormal_bone_strength0.85667637
88MP0003279_aneurysm0.85037415
89MP0009763_increased_sensitivity_to0.82606795
90MP0005076_abnormal_cell_differentiation0.81526659
91MP0002254_reproductive_system_inflammat0.81416188
92MP0008004_abnormal_stomach_pH0.80411929
93MP0003656_abnormal_erythrocyte_physiolo0.78709635
94MP0005164_abnormal_response_to0.77212802
95MP0005167_abnormal_blood-brain_barrier0.76833251
96MP0003091_abnormal_cell_migration0.74706594
97MP0001849_ear_inflammation0.74054844
98MP0004782_abnormal_surfactant_physiolog0.73813739
99MP0000249_abnormal_blood_vessel0.73114232
100MP0002136_abnormal_kidney_physiology0.70401127
101MP0000371_diluted_coat_color0.68851624
102MP0002090_abnormal_vision0.68786080
103MP0006054_spinal_hemorrhage0.68365960
104MP0000015_abnormal_ear_pigmentation0.67578087
105MP0002019_abnormal_tumor_incidence0.67146866
106MP0005275_abnormal_skin_tensile0.65480580
107MP0001663_abnormal_digestive_system0.65372812
108MP0009765_abnormal_xenobiotic_induced0.64500166
109MP0005319_abnormal_enzyme/_coenzyme0.63621244
110MP0003634_abnormal_glial_cell0.62929051
111MP0000569_abnormal_digit_pigmentation0.62801971
112MP0003690_abnormal_glial_cell0.62323989
113MP0002877_abnormal_melanocyte_morpholog0.59754218
114MP0005584_abnormal_enzyme/coenzyme_acti0.59347072
115MP0008874_decreased_physiological_sensi0.58885155
116MP0000609_abnormal_liver_physiology0.57321344
117MP0003183_abnormal_peptide_metabolism0.57187289
118MP0002332_abnormal_exercise_endurance0.57127350
119MP0001216_abnormal_epidermal_layer0.57118963
120MP0002837_dystrophic_cardiac_calcinosis0.54334562
121MP0000767_abnormal_smooth_muscle0.52434852

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.64225444
2Eczematoid dermatitis (HP:0000976)6.21139722
3Recurrent bacterial skin infections (HP:0005406)5.61477986
4Recurrent gram-negative bacterial infections (HP:0005420)5.02601117
5Vacuolated lymphocytes (HP:0001922)4.97084993
6Abnormality of macrophages (HP:0004311)4.78377046
7Increased cerebral lipofuscin (HP:0011813)4.76319146
8Myositis (HP:0100614)4.33189077
9Elevated erythrocyte sedimentation rate (HP:0003565)4.30867745
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.12102213
11Mediastinal lymphadenopathy (HP:0100721)3.91026194
12Recurrent skin infections (HP:0001581)3.80686454
13Chronic obstructive pulmonary disease (HP:0006510)3.61957008
14Obstructive lung disease (HP:0006536)3.61957008
15Orchitis (HP:0100796)3.60225038
16Stomatitis (HP:0010280)3.59578272
17Gingivitis (HP:0000230)3.57785081
18Recurrent fungal infections (HP:0002841)3.54433519
19Mutism (HP:0002300)3.47798235
20Neurofibrillary tangles (HP:0002185)3.47036350
21Dysostosis multiplex (HP:0000943)3.44566530
22Systemic lupus erythematosus (HP:0002725)3.42252765
23Abnormality of liposaccharide metabolism (HP:0010968)3.28059494
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.28059494
25Abnormality of glycolipid metabolism (HP:0010969)3.28059494
26Interstitial pulmonary disease (HP:0006530)3.27348612
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.24596567
28Pustule (HP:0200039)3.22750971
29Disinhibition (HP:0000734)3.20379305
30Cellulitis (HP:0100658)3.18876916
31Axonal loss (HP:0003447)3.17024421
32Autoimmune thrombocytopenia (HP:0001973)3.11399187
33Retrobulbar optic neuritis (HP:0100654)3.05377568
34Optic neuritis (HP:0100653)3.05377568
35IgM deficiency (HP:0002850)2.98875223
36Vasculitis (HP:0002633)2.96105408
37Petechiae (HP:0000967)2.95602306
38Nuclear cataract (HP:0100018)2.93504453
39Chronic otitis media (HP:0000389)2.89483452
40Upper motor neuron abnormality (HP:0002127)2.88359656
41Urinary glycosaminoglycan excretion (HP:0003541)2.88019180
42Mucopolysacchariduria (HP:0008155)2.88019180
43Basal ganglia calcification (HP:0002135)2.82087302
44Amyloidosis (HP:0011034)2.80844420
45Recurrent viral infections (HP:0004429)2.77584541
46Loss of speech (HP:0002371)2.77158579
47Recurrent cutaneous fungal infections (HP:0011370)2.75962434
48Chronic mucocutaneous candidiasis (HP:0002728)2.75962434
49Apathy (HP:0000741)2.69003674
50Increased serum ferritin (HP:0003281)2.67855978
51Abnormality of polysaccharide metabolism (HP:0011012)2.66378975
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66378975
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66378975
54Progressive neurologic deterioration (HP:0002344)2.64560132
55Glomerulonephritis (HP:0000099)2.60957352
56Recurrent bronchitis (HP:0002837)2.60598189
57Vertebral compression fractures (HP:0002953)2.60566281
58Urticaria (HP:0001025)2.59873469
59Periodontitis (HP:0000704)2.58913825
60Meningitis (HP:0001287)2.54810593
61Neuronal loss in central nervous system (HP:0002529)2.53787740
62Agnosia (HP:0010524)2.52028488
63Recurrent pneumonia (HP:0006532)2.49673227
64Cerebral inclusion bodies (HP:0100314)2.47729759
65Osteomyelitis (HP:0002754)2.47509258
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.40847101
67Hematochezia (HP:0002573)2.39350635
68Osteolytic defects of the hand bones (HP:0009699)2.38904711
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.38904711
70Prolonged neonatal jaundice (HP:0006579)2.37108370
71Thrombocytosis (HP:0001894)2.35728503
72Nasal polyposis (HP:0100582)2.32539203
73Hepatosplenomegaly (HP:0001433)2.32214111
74Pulmonary infiltrates (HP:0002113)2.31435114
75Abnormality of the nasal mucosa (HP:0000433)2.31240350
76Myocardial infarction (HP:0001658)2.30698314
77Metaphyseal irregularity (HP:0003025)2.28707810
78Retinal atrophy (HP:0001105)2.28626672
79Recurrent lower respiratory tract infections (HP:0002783)2.26123074
80Arterial thrombosis (HP:0004420)2.25731131
81Leukocytosis (HP:0001974)2.24480737
82Inflammation of the large intestine (HP:0002037)2.23157583
83Gastrointestinal stroma tumor (HP:0100723)2.23041498
84Personality changes (HP:0000751)2.22074118
85Increased IgM level (HP:0003496)2.21740810
86Hypergammaglobulinemia (HP:0010702)2.20113749
87Thick nail (HP:0001805)2.19503356
88Prostate neoplasm (HP:0100787)2.17198356
89Emphysema (HP:0002097)2.17057658
90Abnormality of T cell physiology (HP:0011840)2.14374115
91Gastrointestinal inflammation (HP:0004386)2.10386521
92Skin ulcer (HP:0200042)2.09565927
93Inappropriate behavior (HP:0000719)2.09151291
94Dementia (HP:0000726)2.08261039
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07784951
96Spontaneous hematomas (HP:0007420)2.07137442
97Abnormality of iron homeostasis (HP:0011031)2.06967103
98Lymphopenia (HP:0001888)2.06800613
99Hemoptysis (HP:0002105)2.04983620
100Abnormality of T cells (HP:0002843)2.04397009
101Poor head control (HP:0002421)2.03743280
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.02178063
103Gingival bleeding (HP:0000225)2.01496453
104Abnormality of the periventricular white matter (HP:0002518)2.00655618
105Thoracic kyphosis (HP:0002942)2.00323909
106Bone pain (HP:0002653)1.98647658
107Premature loss of primary teeth (HP:0006323)1.95977312
108Abnormality of the lumbar spine (HP:0100712)1.95386099
109Increased IgE level (HP:0003212)1.93992490
110Diminished motivation (HP:0000745)1.93617656
111Colitis (HP:0002583)1.93406660
112Cardiomegaly (HP:0001640)1.93186567
113Asymmetric septal hypertrophy (HP:0001670)1.92718176
114Epistaxis (HP:0000421)1.91053953
115Complement deficiency (HP:0004431)1.89308678
116Beaking of vertebral bodies (HP:0004568)1.88690022
117Arthralgia (HP:0002829)1.88469371
118Albinism (HP:0001022)1.88468622
119Purpura (HP:0000979)1.87658065
120Supranuclear gaze palsy (HP:0000605)1.85975360
121Xanthomatosis (HP:0000991)1.85744858
122Peripheral demyelination (HP:0011096)1.85125718
123Prolonged bleeding time (HP:0003010)1.84932436
124J-shaped sella turcica (HP:0002680)1.84913615
125IgA deficiency (HP:0002720)1.84842458
126Malnutrition (HP:0004395)1.84639035
127T lymphocytopenia (HP:0005403)1.84249664
128Sepsis (HP:0100806)1.83504571
129Pathologic fracture (HP:0002756)1.81786060
130Restrictive lung disease (HP:0002091)1.81221963
131Polyneuropathy (HP:0001271)1.81133723
132Neoplasm of head and neck (HP:0012288)1.78858750
133Esophageal neoplasm (HP:0100751)1.78858750
134Abnormality of complement system (HP:0005339)1.77287633
135Multiple enchondromatosis (HP:0005701)1.74642131
136Global brain atrophy (HP:0002283)1.69944651
137Increased CSF protein (HP:0002922)1.66959799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.91405299
2TBK13.25726587
3BLK3.24088287
4NME23.03768518
5KIT2.87406455
6ERN12.82967775
7MAP3K142.77656240
8GRK72.59516446
9TYK22.59274506
10RIPK42.48243304
11IRAK42.41747599
12ZAP702.35229692
13PBK2.25569636
14IKBKE2.21697221
15JAK32.20233377
16TXK2.13082968
17IRAK32.06799236
18PIM22.02946511
19IKBKB1.96610937
20PRPF4B1.71116000
21TESK21.62938196
22TRIB31.62811372
23DDR21.62379300
24MAP2K31.61998720
25BTK1.60975891
26SYK1.58921050
27TGFBR21.56792657
28RPS6KA41.53259473
29TESK11.48845360
30JAK11.48366776
31STK101.48245493
32LRRK21.45324941
33KDR1.44694410
34HCK1.44523835
35CSF1R1.44035603
36CSK1.39211879
37NEK91.36621532
38MAP3K111.30747945
39SCYL21.27709542
40PKN21.27218801
41LCK1.26922861
42TEC1.26791297
43TTN1.19534272
44TAOK11.19285871
45LYN1.18790848
46MAP3K31.14091557
47TRPM71.13250420
48MAP3K121.10031037
49MAP3K131.08526501
50PDK21.03221964
51CHUK1.00470664
52CDC42BPA0.98055156
53MATK0.95503360
54ABL20.94634507
55FES0.91879507
56MST40.91625534
57PAK40.91440727
58PIM10.90522021
59EPHB10.90399277
60BMPR20.86491529
61FGFR40.79149660
62ITK0.77727709
63SIK30.76919872
64JAK20.76168696
65BCKDK0.76091063
66FGR0.75278135
67BMX0.75256084
68MOS0.72752182
69EIF2AK10.69258061
70TAOK30.63927480
71MARK30.63657961
72PRKCD0.63328063
73TGFBR10.62115423
74RPS6KA20.61963749
75ABL10.61232089
76PDPK10.60924021
77ADRBK20.60404832
78GRK60.59935199
79FGFR30.59283850
80MAP2K60.58739307
81MAPKAPK30.58095589
82PTK60.56756934
83STK40.55895855
84FLT30.55812925
85MAP3K60.53815334
86EGFR0.53116423
87ERBB30.51620427
88RPS6KL10.50718121
89RPS6KC10.50718121
90CAMKK20.50457803
91IRAK20.50445124
92MST1R0.50416586
93EPHA20.49271855
94ILK0.48507381
95MAP3K80.47638282
96RIPK10.47494762
97PRKG20.46622409
98DAPK30.45941457
99MAPKAPK20.45838152
100DAPK10.44848834
101LIMK10.43469383
102PDK10.42384877
103EPHB20.42039966
104EIF2AK30.40441085
105CLK10.39640589
106STK240.39136853
107EEF2K0.38657021
108CAMK1D0.37604110
109TNK20.37047726
110RPS6KA60.36563007
111EIF2AK20.36470338
112TAOK20.35959882
113MAP3K10.35016183
114MAPK40.34728755
115CDK60.34580858
116FYN0.34179768
117SIK10.34119399
118ARAF0.32674148
119MAP2K20.31781811
120PDGFRB0.31577765
121LMTK20.31315668
122MAP3K50.31014925
123ACVR1B0.30290330
124MAP3K100.29595501
125PAK10.29477909
126MAPK70.29139836
127PRKCQ0.28164166
128PIK3CG0.26576670
129IGF1R0.25341406
130EPHA30.25149991

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.27457063
2Lysosome_Homo sapiens_hsa041422.43072098
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.41835670
4Staphylococcus aureus infection_Homo sapiens_hsa051502.41781525
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39820985
6Osteoclast differentiation_Homo sapiens_hsa043802.37408562
7Legionellosis_Homo sapiens_hsa051342.24949913
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19430752
9Malaria_Homo sapiens_hsa051442.14076927
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.13243897
11Tuberculosis_Homo sapiens_hsa051522.09910794
12Other glycan degradation_Homo sapiens_hsa005112.09568515
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08729637
14Pertussis_Homo sapiens_hsa051332.08132941
15Measles_Homo sapiens_hsa051622.02930268
16Graft-versus-host disease_Homo sapiens_hsa053321.99267659
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.99141522
18Hematopoietic cell lineage_Homo sapiens_hsa046401.98757764
19Primary immunodeficiency_Homo sapiens_hsa053401.90058367
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89425232
21Allograft rejection_Homo sapiens_hsa053301.88948475
22Antigen processing and presentation_Homo sapiens_hsa046121.87404119
23Rheumatoid arthritis_Homo sapiens_hsa053231.85755676
24Asthma_Homo sapiens_hsa053101.84780922
25B cell receptor signaling pathway_Homo sapiens_hsa046621.84709055
26Phagosome_Homo sapiens_hsa041451.77943594
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71601256
28Shigellosis_Homo sapiens_hsa051311.68034264
29Salmonella infection_Homo sapiens_hsa051321.66639557
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66148179
31Toxoplasmosis_Homo sapiens_hsa051451.56474054
32Apoptosis_Homo sapiens_hsa042101.54766950
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49317329
34TNF signaling pathway_Homo sapiens_hsa046681.47933528
35Influenza A_Homo sapiens_hsa051641.46781399
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39265008
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.38015367
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37815625
39Herpes simplex infection_Homo sapiens_hsa051681.35162559
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29759770
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26878414
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.25539142
43Viral myocarditis_Homo sapiens_hsa054161.25159885
44Chemokine signaling pathway_Homo sapiens_hsa040621.18468743
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14853783
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14117721
47T cell receptor signaling pathway_Homo sapiens_hsa046601.11262106
48Hepatitis B_Homo sapiens_hsa051611.09556288
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00805011
50Autoimmune thyroid disease_Homo sapiens_hsa053200.91507866
51Bladder cancer_Homo sapiens_hsa052190.90606566
52Mineral absorption_Homo sapiens_hsa049780.90234112
53Prion diseases_Homo sapiens_hsa050200.88358442
54Acute myeloid leukemia_Homo sapiens_hsa052210.87364294
55Caffeine metabolism_Homo sapiens_hsa002320.86065896
56Hepatitis C_Homo sapiens_hsa051600.84854477
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84344366
58Amoebiasis_Homo sapiens_hsa051460.84232717
59Platelet activation_Homo sapiens_hsa046110.83972676
60Type I diabetes mellitus_Homo sapiens_hsa049400.82215836
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80116244
62Proteasome_Homo sapiens_hsa030500.79022589
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78036377
64Fructose and mannose metabolism_Homo sapiens_hsa000510.77512930
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76213231
66African trypanosomiasis_Homo sapiens_hsa051430.76192875
67Chronic myeloid leukemia_Homo sapiens_hsa052200.74525469
68Epstein-Barr virus infection_Homo sapiens_hsa051690.70949471
69Sulfur metabolism_Homo sapiens_hsa009200.69649251
70Pancreatic cancer_Homo sapiens_hsa052120.68418866
71Ribosome_Homo sapiens_hsa030100.67789853
72Viral carcinogenesis_Homo sapiens_hsa052030.67588131
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64974172
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.62727183
75p53 signaling pathway_Homo sapiens_hsa041150.59707023
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.57151475
77HIF-1 signaling pathway_Homo sapiens_hsa040660.55495090
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55353124
79Small cell lung cancer_Homo sapiens_hsa052220.55141010
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54551690
81VEGF signaling pathway_Homo sapiens_hsa043700.54526995
82Collecting duct acid secretion_Homo sapiens_hsa049660.54293691
83Prolactin signaling pathway_Homo sapiens_hsa049170.52760200
84Endocytosis_Homo sapiens_hsa041440.52103345
85HTLV-I infection_Homo sapiens_hsa051660.51881865
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51261888
87Proteoglycans in cancer_Homo sapiens_hsa052050.50885124
88Glutathione metabolism_Homo sapiens_hsa004800.49611061
89Sphingolipid metabolism_Homo sapiens_hsa006000.44179643
90PPAR signaling pathway_Homo sapiens_hsa033200.43795823
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42722580
92Complement and coagulation cascades_Homo sapiens_hsa046100.42450392
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.42145606
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.39531849
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38779123
96Focal adhesion_Homo sapiens_hsa045100.37450600
97Systemic lupus erythematosus_Homo sapiens_hsa053220.33096184
98Vibrio cholerae infection_Homo sapiens_hsa051100.32773395
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31677405
100Renin-angiotensin system_Homo sapiens_hsa046140.30804293
101Pentose phosphate pathway_Homo sapiens_hsa000300.30471809
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29774875
103DNA replication_Homo sapiens_hsa030300.29445606
104Galactose metabolism_Homo sapiens_hsa000520.28556445
105ECM-receptor interaction_Homo sapiens_hsa045120.26655192
106Synaptic vesicle cycle_Homo sapiens_hsa047210.26216729
107Base excision repair_Homo sapiens_hsa034100.25129428
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24460426
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22918243
110MicroRNAs in cancer_Homo sapiens_hsa052060.20690388
111Notch signaling pathway_Homo sapiens_hsa043300.13189791
112Fatty acid elongation_Homo sapiens_hsa000620.08914857
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.06881783
114GnRH signaling pathway_Homo sapiens_hsa049120.06448016

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