CAPN10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.14565863
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.14565863
3L-phenylalanine metabolic process (GO:0006558)5.98313219
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.98313219
5positive regulation of gamma-delta T cell activation (GO:0046645)5.25075806
6negative regulation of cell killing (GO:0031342)5.11811634
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.11811634
8pyrimidine nucleobase catabolic process (GO:0006208)5.07003625
9positive regulation by symbiont of host defense response (GO:0052509)4.95718839
10modulation by symbiont of host defense response (GO:0052031)4.95718839
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95718839
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95718839
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.95718839
14modulation by symbiont of host immune response (GO:0052553)4.95718839
15negative regulation of erythrocyte differentiation (GO:0045647)4.79070802
16aromatic amino acid family catabolic process (GO:0009074)4.62001186
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48953092
18antigen processing and presentation of endogenous antigen (GO:0019883)4.46093528
19macrophage activation involved in immune response (GO:0002281)4.32448886
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.28847248
21serine family amino acid biosynthetic process (GO:0009070)4.28155003
22glyoxylate metabolic process (GO:0046487)4.27060148
23cellular ketone body metabolic process (GO:0046950)4.21441374
24regulation of gamma-delta T cell activation (GO:0046643)4.19544545
25alpha-linolenic acid metabolic process (GO:0036109)4.17496189
26sulfur amino acid catabolic process (GO:0000098)4.16575901
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16526416
28cysteine metabolic process (GO:0006534)4.13725542
29L-serine metabolic process (GO:0006563)4.12965204
30keratinization (GO:0031424)4.11929108
31protein retention in ER lumen (GO:0006621)4.11560200
32lysine metabolic process (GO:0006553)4.11278358
33lysine catabolic process (GO:0006554)4.11278358
34negative regulation of fibrinolysis (GO:0051918)4.08041661
35positive T cell selection (GO:0043368)4.07288808
36thymic T cell selection (GO:0045061)4.02821824
37regulation of gamma-delta T cell differentiation (GO:0045586)4.01240470
38nucleobase catabolic process (GO:0046113)3.98562896
39regulation of B cell receptor signaling pathway (GO:0050855)3.96611004
40serine family amino acid catabolic process (GO:0009071)3.95979988
41T cell selection (GO:0045058)3.95298708
42glycine metabolic process (GO:0006544)3.94791707
43plasma lipoprotein particle assembly (GO:0034377)3.94496016
44response to muramyl dipeptide (GO:0032495)3.91137949
45mannose metabolic process (GO:0006013)3.89985236
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86212401
47regulation of fibrinolysis (GO:0051917)3.85422842
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83835492
49kynurenine metabolic process (GO:0070189)3.83259159
50regulation of receptor recycling (GO:0001919)3.77594276
51serine family amino acid metabolic process (GO:0009069)3.77158508
52B cell receptor signaling pathway (GO:0050853)3.76401691
53response to peptidoglycan (GO:0032494)3.75658219
54high-density lipoprotein particle remodeling (GO:0034375)3.71689787
55negative thymic T cell selection (GO:0045060)3.70889130
56glutamate metabolic process (GO:0006536)3.70399325
57bile acid biosynthetic process (GO:0006699)3.68800635
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68418828
59phospholipid efflux (GO:0033700)3.66168836
60negative regulation of cAMP-mediated signaling (GO:0043951)3.65314245
61intestinal cholesterol absorption (GO:0030299)3.62942390
62ketone body metabolic process (GO:1902224)3.62037759
63cholesterol efflux (GO:0033344)3.60790032
64urea metabolic process (GO:0019627)3.58600383
65urea cycle (GO:0000050)3.58600383
66negative regulation of catenin import into nucleus (GO:0035414)3.57307393
67amino-acid betaine metabolic process (GO:0006577)3.56029823
68regulation of interferon-beta biosynthetic process (GO:0045357)3.54956180
69negative regulation of lipase activity (GO:0060192)3.54241577
70negative T cell selection (GO:0043383)3.53083010
71aromatic amino acid family metabolic process (GO:0009072)3.52379217
72cellular extravasation (GO:0045123)3.51205195
73leukocyte aggregation (GO:0070486)3.50341730
74very-low-density lipoprotein particle assembly (GO:0034379)3.49565183
75protein-lipid complex assembly (GO:0065005)3.49005290
76alpha-amino acid catabolic process (GO:1901606)3.48567420
77tryptophan catabolic process (GO:0006569)3.48223383
78indole-containing compound catabolic process (GO:0042436)3.48223383
79indolalkylamine catabolic process (GO:0046218)3.48223383
80tyrosine metabolic process (GO:0006570)3.46501131
81cellular modified amino acid catabolic process (GO:0042219)3.44515160
82negative regulation of cholesterol transport (GO:0032375)3.40291193
83negative regulation of sterol transport (GO:0032372)3.40291193
84positive regulation of histone deacetylation (GO:0031065)3.39812507
85tryptophan metabolic process (GO:0006568)3.37292239
86negative regulation of interleukin-12 production (GO:0032695)3.32468897
87nitrogen cycle metabolic process (GO:0071941)3.32342919
88positive regulation of B cell differentiation (GO:0045579)3.30757604
89NIK/NF-kappaB signaling (GO:0038061)3.30650229
90cellular amino acid catabolic process (GO:0009063)3.30055346
91regulation of protein activation cascade (GO:2000257)3.28642227
92regulation of mast cell degranulation (GO:0043304)3.28442792
93bile acid metabolic process (GO:0008206)3.26832033
94detection of bacterium (GO:0016045)3.24110015
95homocysteine metabolic process (GO:0050667)3.23568939
96aspartate family amino acid catabolic process (GO:0009068)3.22614532
97drug catabolic process (GO:0042737)3.21568838
98negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21279097
99regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21255657
100coenzyme catabolic process (GO:0009109)3.20397153
101detection of other organism (GO:0098543)3.19376677
102defense response to protozoan (GO:0042832)3.19319213
103negative regulation of phagocytosis (GO:0050765)3.18465943
104antigen processing and presentation via MHC class Ib (GO:0002475)3.16478784
105tolerance induction (GO:0002507)3.16208022
106reverse cholesterol transport (GO:0043691)3.16069255
107germinal center formation (GO:0002467)3.14556074
108regulation of leukocyte degranulation (GO:0043300)3.13336922
109regulation of B cell differentiation (GO:0045577)3.13314045
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10000099
111response to host immune response (GO:0052572)3.10000099
112fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.08909909
113G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08828217
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08271563
115heme transport (GO:0015886)3.07986061
116regulation of ARF GTPase activity (GO:0032312)3.06317129
117positive regulation of mast cell activation (GO:0033005)3.06185518
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04696630
119complement activation, alternative pathway (GO:0006957)3.00669239
120acetyl-CoA metabolic process (GO:0006084)3.00661575
121negative regulation of lymphocyte mediated immunity (GO:0002707)2.98830171
122protein-lipid complex remodeling (GO:0034368)2.98343205
123macromolecular complex remodeling (GO:0034367)2.98343205
124plasma lipoprotein particle remodeling (GO:0034369)2.98343205
125ethanol oxidation (GO:0006069)2.98311817
126regulation of complement activation (GO:0030449)2.98068884
127response to host (GO:0075136)2.96521058
128response to host defenses (GO:0052200)2.96521058
129response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96521058
130negative regulation of innate immune response (GO:0045824)2.95549900
131arginine metabolic process (GO:0006525)2.94054907
132regulation of mast cell activation involved in immune response (GO:0033006)2.92977347
133triglyceride homeostasis (GO:0070328)2.92120987
134acylglycerol homeostasis (GO:0055090)2.92120987
135regulation of cholesterol esterification (GO:0010872)2.91594572
136response to protozoan (GO:0001562)2.90501978
137positive regulation of CREB transcription factor activity (GO:0032793)2.89926883
138positive thymic T cell selection (GO:0045059)2.89668535
139T cell migration (GO:0072678)2.88802925
140peptidyl-glutamic acid carboxylation (GO:0017187)2.88425197
141protein carboxylation (GO:0018214)2.88425197
142myeloid cell activation involved in immune response (GO:0002275)2.88315794
143imidazole-containing compound metabolic process (GO:0052803)2.88267290
144negative regulation of leukocyte mediated immunity (GO:0002704)2.88253279
145neutrophil activation involved in immune response (GO:0002283)2.87688107
146positive regulation of Rap GTPase activity (GO:0032854)2.87486385
147regulation of cholesterol homeostasis (GO:2000188)2.86431538
148macrophage activation (GO:0042116)2.86213253
149response to interleukin-15 (GO:0070672)2.86010591
150positive regulation of mast cell degranulation (GO:0043306)2.85407579
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.85407579
152negative regulation of granulocyte differentiation (GO:0030853)2.84691577
153folic acid metabolic process (GO:0046655)2.83400481
154plasma lipoprotein particle organization (GO:0071827)2.82957844
155positive regulation of protein deacetylation (GO:0090312)2.81840761
156natural killer cell differentiation (GO:0001779)2.80638560
157phosphatidylglycerol biosynthetic process (GO:0006655)2.79263586
158plasma lipoprotein particle clearance (GO:0034381)2.79071556
159CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.78883718
160one-carbon metabolic process (GO:0006730)2.77307620
161modulation by virus of host process (GO:0019054)2.76326387
162positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76321543
163mucosal-associated lymphoid tissue development (GO:0048537)2.75938323
164Peyers patch development (GO:0048541)2.75938323
165regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.74943375
166microglial cell activation (GO:0001774)2.74187427
167regulation of synaptic vesicle exocytosis (GO:2000300)2.71356681
168carboxylic acid catabolic process (GO:0046395)2.70901170
169organic acid catabolic process (GO:0016054)2.70901170
1704-hydroxyproline metabolic process (GO:0019471)2.70554435
171regulation of ARF protein signal transduction (GO:0032012)2.70003912
172negative regulation of oligodendrocyte differentiation (GO:0048715)2.69533539
173regulation of regulated secretory pathway (GO:1903305)2.69204623
174tooth mineralization (GO:0034505)2.69168686
175immunoglobulin mediated immune response (GO:0016064)2.67732807
176B cell homeostasis (GO:0001782)2.67388837
177dicarboxylic acid biosynthetic process (GO:0043650)2.64573543
178regulation of triglyceride catabolic process (GO:0010896)2.63787215
179protein-lipid complex subunit organization (GO:0071825)2.63739885
180regulation of mast cell activation (GO:0033003)2.62132807
181N-acetylneuraminate metabolic process (GO:0006054)2.61345476
182antigen receptor-mediated signaling pathway (GO:0050851)2.59952610
183negative regulation of interleukin-6 production (GO:0032715)2.59834589
184positive regulation of antigen processing and presentation (GO:0002579)2.59588723
185activated T cell proliferation (GO:0050798)2.59285585
186chaperone-mediated protein complex assembly (GO:0051131)2.58981375
187negative regulation of T cell mediated immunity (GO:0002710)2.58304067
188ethanol metabolic process (GO:0006067)2.58028226
1893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58023058
190negative regulation of type 2 immune response (GO:0002829)2.56346703
191histone H3-K36 demethylation (GO:0070544)2.55725180
192respiratory burst (GO:0045730)2.55639472
193response to type I interferon (GO:0034340)2.54049607
194detection of external biotic stimulus (GO:0098581)2.53443364
195negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52830651
196modulation by symbiont of host cellular process (GO:0044068)2.52245087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.16080028
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.71193154
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.11429514
4VDR_21846776_ChIP-Seq_THP-1_Human3.77698056
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.44952362
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.21232482
7KDM2B_26808549_Chip-Seq_SUP-B15_Human3.07880946
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.97856293
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78571290
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.67597714
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.53793382
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.49716801
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49511596
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47748468
15* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.42046736
16TCF7_22412390_ChIP-Seq_EML_Mouse2.38167424
17VDR_24763502_ChIP-Seq_THP-1_Human2.33061774
18ZNF263_19887448_ChIP-Seq_K562_Human2.27013767
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.26431859
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.23588557
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16035955
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08409739
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06310846
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04336257
25MAF_26560356_Chip-Seq_TH1_Human2.03943166
26MAF_26560356_Chip-Seq_TH2_Human2.02025381
27UTX_26944678_Chip-Seq_JUKART_Human1.99892281
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97377993
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93495799
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89908761
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87356055
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.76319663
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.75972934
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.75280537
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74101286
36SCL_19346495_ChIP-Seq_HPC-7_Human1.73804266
37* SMC4_20622854_ChIP-Seq_HELA_Human1.69452571
38* LXR_22292898_ChIP-Seq_THP-1_Human1.69093800
39CLOCK_20551151_ChIP-Seq_293T_Human1.68849055
40* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68062687
41CTCF_27219007_Chip-Seq_Bcells_Human1.67616711
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.67253534
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66745021
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66358562
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65964744
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60023045
47* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57532720
48SPI1_23127762_ChIP-Seq_K562_Human1.56416443
49VDR_22108803_ChIP-Seq_LS180_Human1.55505025
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55266759
51* GATA1_19941827_ChIP-Seq_MEL_Mouse1.53062468
52DROSHA_22980978_ChIP-Seq_HELA_Human1.51264037
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50499503
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50496626
55* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48690607
56CTCF_20526341_ChIP-Seq_ESCs_Human1.48115597
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46118404
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45376808
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.42648856
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42373880
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42328172
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41288375
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40437131
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.39831618
65ERG_20517297_ChIP-Seq_VCAP_Human1.37590680
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36779812
67PHF8_20622854_ChIP-Seq_HELA_Human1.36411051
68XRN2_22483619_ChIP-Seq_HELA_Human1.36386911
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36244789
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34098086
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.32121909
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31927691
73RUNX_20019798_ChIP-Seq_JUKART_Human1.31449170
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30843846
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30823876
76* SPI1_23547873_ChIP-Seq_NB4_Human1.28318045
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28149092
78* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27923451
79CREB1_26743006_Chip-Seq_LNCaP_Human1.27472962
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.27079726
81* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26741608
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26036741
83E2F1_20622854_ChIP-Seq_HELA_Human1.25133685
84* ATF3_27146783_Chip-Seq_COLON_Human1.24981723
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23920114
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.23207336
87* MYC_22102868_ChIP-Seq_BL_Human1.21927103
88* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21702469
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21127372
90* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20857411
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20770617
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19950288
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.19602951
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19357477
95NCOR1_26117541_ChIP-Seq_K562_Human1.18974211
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18886963
97OCT4_19829295_ChIP-Seq_ESCs_Human1.18532444
98MYB_26560356_Chip-Seq_TH1_Human1.17035099
99* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16586481
100BCOR_27268052_Chip-Seq_Bcells_Human1.16258183
101TP53_22127205_ChIP-Seq_IMR90_Human1.15786276
102* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14737432
103TP63_22573176_ChIP-Seq_HFKS_Human1.14639735
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14064673
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.13914937
106RARB_24833708_ChIP-Seq_LIVER_Mouse1.12996473
107SA1_27219007_Chip-Seq_Bcells_Human1.12980211
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11362291
109KDM2B_26808549_Chip-Seq_K562_Human1.10518978
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.10422518
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10352450
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09949079
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09383354
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09032719
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08010708
116EZH2_22144423_ChIP-Seq_EOC_Human1.07680353
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07634390
118CIITA_25753668_ChIP-Seq_RAJI_Human1.06810300
119P68_20966046_ChIP-Seq_HELA_Human1.06500639
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06048791
121* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05748333
122RACK7_27058665_Chip-Seq_MCF-7_Human1.05676189
123REST_21632747_ChIP-Seq_MESCs_Mouse1.05345294
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05110250
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05029377
126* MYB_26560356_Chip-Seq_TH2_Human1.04917620
127* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04879639
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04408371
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04037191
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03944395
131BP1_19119308_ChIP-ChIP_Hs578T_Human1.03192491
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02583133
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02560981
134KDM2B_26808549_Chip-Seq_DND41_Human1.01874788
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01778330
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01231411
137CTCF_21964334_Chip-Seq_Bcells_Human1.01010969
138HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00827056
139PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00031744
140OCT4_20526341_ChIP-Seq_ESCs_Human1.00003280
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.99513143
142TET1_21490601_ChIP-Seq_MESCs_Mouse0.96173047
143* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94849535
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93815264
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93099075
146BCL6_27268052_Chip-Seq_Bcells_Human0.92815926
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92549495
148SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92429393
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92425922
150P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91759104
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.91558399
152OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91412395
153SOX2_21211035_ChIP-Seq_LN229_Human0.90223714
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89912795
155UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89206131
156* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88602691
157KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86002851
158ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84927655
159ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84669505
160SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83581820
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83483594
162* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83336893
163* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83029740
164* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82778167
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82702522
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82040544
167KLF4_19829295_ChIP-Seq_ESCs_Human0.81813660
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81186644
169SPI1_20517297_ChIP-Seq_HL60_Human0.80484224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.04470217
2MP0005360_urolithiasis5.21960952
3MP0005365_abnormal_bile_salt4.59601658
4MP0005085_abnormal_gallbladder_physiolo4.05678829
5MP0003436_decreased_susceptibility_to3.79801534
6MP0003172_abnormal_lysosome_physiology3.68726469
7MP0003011_delayed_dark_adaptation3.19931497
8MP0003806_abnormal_nucleotide_metabolis3.03687001
9MP0009278_abnormal_bone_marrow3.00997408
10MP0008875_abnormal_xenobiotic_pharmacok2.90574437
11MP0010329_abnormal_lipoprotein_level2.88096495
12MP0001800_abnormal_humoral_immune2.76805774
13MP0001835_abnormal_antigen_presentation2.74395065
14MP0005058_abnormal_lysosome_morphology2.72119814
15MP0000685_abnormal_immune_system2.71256347
16MP0003763_abnormal_thymus_physiology2.63585406
17MP0005387_immune_system_phenotype2.49719291
18MP0001790_abnormal_immune_system2.49719291
19MP0002419_abnormal_innate_immunity2.48119536
20MP0005000_abnormal_immune_tolerance2.47327115
21MP0005025_abnormal_response_to2.46488125
22MP0002163_abnormal_gland_morphology2.46201280
23MP0005671_abnormal_response_to2.43608122
24MP0003252_abnormal_bile_duct2.38916111
25MP0002723_abnormal_immune_serum2.38025834
26MP0002420_abnormal_adaptive_immunity2.34923693
27MP0005332_abnormal_amino_acid2.33562318
28MP0001819_abnormal_immune_cell2.32902502
29MP0009840_abnormal_foam_cell2.28428259
30MP0002452_abnormal_antigen_presenting2.23198449
31MP0009333_abnormal_splenocyte_physiolog2.17992163
32MP0001873_stomach_inflammation2.17617753
33MP0005083_abnormal_biliary_tract2.17057371
34MP0003329_amyloid_beta_deposits2.05546947
35MP0005379_endocrine/exocrine_gland_phen2.04923825
36MP0001849_ear_inflammation1.91881583
37MP0004859_abnormal_synaptic_plasticity1.91701222
38MP0002405_respiratory_system_inflammati1.90562250
39MP0005187_abnormal_penis_morphology1.88275135
40MP0002909_abnormal_adrenal_gland1.87063635
41MP0002254_reproductive_system_inflammat1.85749023
42MP0000716_abnormal_immune_system1.84164950
43MP0008260_abnormal_autophagy1.82942422
44MP0002398_abnormal_bone_marrow1.82427244
45MP0003183_abnormal_peptide_metabolism1.82022357
46MP0004270_analgesia1.80531172
47MP0003724_increased_susceptibility_to1.76651789
48MP0001666_abnormal_nutrient_absorption1.73045230
49MP0001348_abnormal_lacrimal_gland1.69377701
50MP0002148_abnormal_hypersensitivity_rea1.68687390
51MP0000609_abnormal_liver_physiology1.68573861
52MP0010155_abnormal_intestine_physiology1.67773747
53MP0009785_altered_susceptibility_to1.66735216
54MP0005310_abnormal_salivary_gland1.66663703
55MP0006082_CNS_inflammation1.65805887
56MP0000703_abnormal_thymus_morphology1.61931196
57MP0003693_abnormal_embryo_hatching1.60776969
58MP0004947_skin_inflammation1.60762162
59MP0003195_calcinosis1.59529960
60MP0005220_abnormal_exocrine_pancreas1.55488136
61MP0002138_abnormal_hepatobiliary_system1.55036598
62MP0004381_abnormal_hair_follicle1.53430320
63MP0002118_abnormal_lipid_homeostasis1.50659621
64MP0005464_abnormal_platelet_physiology1.48995345
65MP0002396_abnormal_hematopoietic_system1.48007387
66MP0000689_abnormal_spleen_morphology1.46159191
67MP0004019_abnormal_vitamin_homeostasis1.45966435
68MP0002429_abnormal_blood_cell1.45702034
69MP0001533_abnormal_skeleton_physiology1.44439802
70MP0002722_abnormal_immune_system1.42574366
71MP0001845_abnormal_inflammatory_respons1.39582847
72MP0001545_abnormal_hematopoietic_system1.34740557
73MP0005397_hematopoietic_system_phenotyp1.34740557
74MP0006276_abnormal_autonomic_nervous1.32136682
75MP0001663_abnormal_digestive_system1.29418108
76MP0008877_abnormal_DNA_methylation1.28076642
77MP0003283_abnormal_digestive_organ1.27195727
78MP0002933_joint_inflammation1.26797709
79MP0006035_abnormal_mitochondrial_morpho1.25330590
80MP0003866_abnormal_defecation1.22957890
81MP0001270_distended_abdomen1.22735710
82MP0002733_abnormal_thermal_nociception1.22168699
83MP0005451_abnormal_body_composition1.17493801
84MP0002998_abnormal_bone_remodeling1.17214810
85MP0003136_yellow_coat_color1.16635632
86MP0000678_abnormal_parathyroid_gland1.15912219
87MP0000858_altered_metastatic_potential1.14649612
88MP0004858_abnormal_nervous_system1.13544901
89MP0008469_abnormal_protein_level1.12605214
90MP0000604_amyloidosis1.11422716
91MP0006292_abnormal_olfactory_placode1.09002695
92MP0009672_abnormal_birth_weight1.06164049
93MP0002249_abnormal_larynx_morphology1.04561778
94MP0004130_abnormal_muscle_cell1.02891758
95MP0002064_seizures1.02181991
96MP0004811_abnormal_neuron_physiology1.01104533
97MP0005670_abnormal_white_adipose1.00749336
98MP0004885_abnormal_endolymph1.00489631
99MP0003119_abnormal_digestive_system0.99820577
100MP0000015_abnormal_ear_pigmentation0.99076349
101MP0002160_abnormal_reproductive_system0.98812910
102MP0004043_abnormal_pH_regulation0.98778499
103MP0002089_abnormal_postnatal_growth/wei0.98579815
104MP0006036_abnormal_mitochondrial_physio0.97868534
105MP0004510_myositis0.96234870
106MP0005584_abnormal_enzyme/coenzyme_acti0.96110030
107MP0003635_abnormal_synaptic_transmissio0.95836438
108MP0000470_abnormal_stomach_morphology0.95000644
109MP0008961_abnormal_basal_metabolism0.94596225
110MP0003705_abnormal_hypodermis_morpholog0.94453696
111MP0002734_abnormal_mechanical_nocicepti0.93114468
112MP0003303_peritoneal_inflammation0.92499442
113MP0009643_abnormal_urine_homeostasis0.92097752
114MP0001944_abnormal_pancreas_morphology0.91377078
115MP0002877_abnormal_melanocyte_morpholog0.90624078
116MP0001986_abnormal_taste_sensitivity0.90422876
117MP0004808_abnormal_hematopoietic_stem0.90285251
118MP0000537_abnormal_urethra_morphology0.90172960
119MP0002009_preneoplasia0.89673974
120MP0003868_abnormal_feces_composition0.89078486
121MP0006072_abnormal_retinal_apoptosis0.88526498
122MP0000955_abnormal_spinal_cord0.86960063
123MP0005410_abnormal_fertilization0.86952053
124MP0004185_abnormal_adipocyte_glucose0.86796520
125MP0005381_digestive/alimentary_phenotyp0.84820775
126MP0004883_abnormal_blood_vessel0.84532717
127MP0002078_abnormal_glucose_homeostasis0.84211642
128MP0005319_abnormal_enzyme/_coenzyme0.84087971
129MP0000490_abnormal_crypts_of0.83077830
130MP0002098_abnormal_vibrissa_morphology0.82970550
131MP0002184_abnormal_innervation0.81775872
132MP0005666_abnormal_adipose_tissue0.80948906
133MP0000358_abnormal_cell_content/0.80482795
134MP0003787_abnormal_imprinting0.79888893
135MP0002277_abnormal_respiratory_mucosa0.79708745
136MP0003828_pulmonary_edema0.77980316
137MP0003123_paternal_imprinting0.77928830
138MP0005636_abnormal_mineral_homeostasis0.77028250
139MP0000598_abnormal_liver_morphology0.75624417
140MP0002063_abnormal_learning/memory/cond0.75029483
141MP0005390_skeleton_phenotype0.74875179
142MP0001502_abnormal_circadian_rhythm0.74551168
143MP0009764_decreased_sensitivity_to0.74131615
144MP0004133_heterotaxia0.73603729
145MP0003861_abnormal_nervous_system0.73325928
146MP0002132_abnormal_respiratory_system0.72931856
147MP0002928_abnormal_bile_duct0.71841594
148MP0005075_abnormal_melanosome_morpholog0.70789457
149MP0001851_eye_inflammation0.70743174
150MP0008789_abnormal_olfactory_epithelium0.70539843
151MP0003453_abnormal_keratinocyte_physiol0.69856366
152MP0003315_abnormal_perineum_morphology0.69429544
153MP0005394_taste/olfaction_phenotype0.69175272
154MP0005499_abnormal_olfactory_system0.69175272
155MP0000538_abnormal_urinary_bladder0.68594694
156MP0009053_abnormal_anal_canal0.68530625
157MP0000778_abnormal_nervous_system0.67698403
158MP0002653_abnormal_ependyma_morphology0.66241570
159MP0003879_abnormal_hair_cell0.66089405
160MP0001730_embryonic_growth_arrest0.65740330
161MP0003690_abnormal_glial_cell0.65199806
162MP0003300_gastrointestinal_ulcer0.64899147
163MP0005375_adipose_tissue_phenotype0.64597057
164MP0009379_abnormal_foot_pigmentation0.64441429
165MP0001968_abnormal_touch/_nociception0.64411098
166MP0000371_diluted_coat_color0.63972364
167MP0002796_impaired_skin_barrier0.63520517
168MP0001970_abnormal_pain_threshold0.63324734
169MP0002152_abnormal_brain_morphology0.62399835
170MP0000750_abnormal_muscle_regeneration0.61980264
171MP0003698_abnormal_male_reproductive0.61761607
172MP0001853_heart_inflammation0.61706695
173MP0001765_abnormal_ion_homeostasis0.61081969
174MP0005409_darkened_coat_color0.60343047
175MP0003656_abnormal_erythrocyte_physiolo0.60160354
176MP0005076_abnormal_cell_differentiation0.57866058
177MP0005647_abnormal_sex_gland0.57743961
178MP0005448_abnormal_energy_balance0.57458106
179MP0003878_abnormal_ear_physiology0.57317320
180MP0005377_hearing/vestibular/ear_phenot0.57317320
181MP0008874_decreased_physiological_sensi0.57116373
182MP0002572_abnormal_emotion/affect_behav0.56609612
183MP0001727_abnormal_embryo_implantation0.56537443
184MP0002751_abnormal_autonomic_nervous0.56257749
185MP0003075_altered_response_to0.55656454
186MP0000681_abnormal_thyroid_gland0.55585102

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.57935323
2Autoimmune hemolytic anemia (HP:0001890)5.15549058
3Deep venous thrombosis (HP:0002625)4.88274214
4Intrahepatic cholestasis (HP:0001406)4.78454748
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.65668536
6Eczematoid dermatitis (HP:0000976)4.54029232
7Hypobetalipoproteinemia (HP:0003563)4.35720810
8Xanthomatosis (HP:0000991)4.19236523
9Abnormal pupillary function (HP:0007686)4.02352924
10Elevated erythrocyte sedimentation rate (HP:0003565)3.94872810
11Abnormality of the Achilles tendon (HP:0005109)3.70751775
12Ketosis (HP:0001946)3.70064936
13Recurrent bacterial skin infections (HP:0005406)3.67933307
14Recurrent fungal infections (HP:0002841)3.64812980
15Recurrent abscess formation (HP:0002722)3.62381388
16Chronic obstructive pulmonary disease (HP:0006510)3.57277764
17Obstructive lung disease (HP:0006536)3.57277764
18Abnormality of macrophages (HP:0004311)3.50373990
19Mediastinal lymphadenopathy (HP:0100721)3.49614205
20Increased cerebral lipofuscin (HP:0011813)3.47232458
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.45801851
22Microretrognathia (HP:0000308)3.44100621
23Myositis (HP:0100614)3.41994788
24Hyperglycinemia (HP:0002154)3.38760923
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.36665127
26Prolonged partial thromboplastin time (HP:0003645)3.36509590
27Achilles tendon contracture (HP:0001771)3.35546681
28Hypochromic anemia (HP:0001931)3.32241490
29Chronic mucocutaneous candidiasis (HP:0002728)3.31567769
30Recurrent cutaneous fungal infections (HP:0011370)3.31567769
31Cortical dysplasia (HP:0002539)3.30157774
32Large eyes (HP:0001090)3.22740722
33Colitis (HP:0002583)3.21648950
34Meningitis (HP:0001287)3.19734223
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.17861575
36Broad distal phalanx of finger (HP:0009836)3.16046797
37Abnormality of glycine metabolism (HP:0010895)3.14796702
38Abnormality of serine family amino acid metabolism (HP:0010894)3.14796702
39Panhypogammaglobulinemia (HP:0003139)3.09769826
40Hyperammonemia (HP:0001987)3.08557391
41Hyperglycinuria (HP:0003108)3.07106958
42Abnormality of the lower motor neuron (HP:0002366)3.04313671
43Abnormality of sulfur amino acid metabolism (HP:0004339)3.00290594
44Orchitis (HP:0100796)2.99851799
45Hyperlipoproteinemia (HP:0010980)2.99723603
46Hypolipoproteinemia (HP:0010981)2.94457492
47Gout (HP:0001997)2.92919196
48Ketoacidosis (HP:0001993)2.91862651
49Agammaglobulinemia (HP:0004432)2.90662503
50Stomatitis (HP:0010280)2.87992542
51Gastrointestinal inflammation (HP:0004386)2.86067159
52Obstructive sleep apnea (HP:0002870)2.84420508
53Cellulitis (HP:0100658)2.81334033
54Pustule (HP:0200039)2.79537133
55Recurrent skin infections (HP:0001581)2.78796660
56Areflexia of lower limbs (HP:0002522)2.78397378
57Abnormality of the common coagulation pathway (HP:0010990)2.76436091
58Optic neuritis (HP:0100653)2.73876020
59Retrobulbar optic neuritis (HP:0100654)2.73876020
60Dysostosis multiplex (HP:0000943)2.64611853
61Thoracic kyphosis (HP:0002942)2.64491462
62Fat malabsorption (HP:0002630)2.62846381
63Inflammation of the large intestine (HP:0002037)2.62307696
64Encephalitis (HP:0002383)2.61230474
65Recurrent gram-negative bacterial infections (HP:0005420)2.60629088
66Epidermoid cyst (HP:0200040)2.59641955
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55196135
68Myokymia (HP:0002411)2.50950689
69Atrioventricular block (HP:0001678)2.50903219
70Vasculitis (HP:0002633)2.50820806
71Recurrent viral infections (HP:0004429)2.49335354
72Abnormality of the fingertips (HP:0001211)2.48584677
73Abnormality of the thoracic spine (HP:0100711)2.47786169
74Hyperacusis (HP:0010780)2.45777411
75Increased IgE level (HP:0003212)2.45511352
76Gingivitis (HP:0000230)2.43926088
77Complement deficiency (HP:0004431)2.40119922
78Thin bony cortex (HP:0002753)2.39070588
79Congenital glaucoma (HP:0001087)2.37596193
80Hypoglycemic coma (HP:0001325)2.35895810
81Concave nail (HP:0001598)2.34630325
82Hypoalphalipoproteinemia (HP:0003233)2.33689893
83Hemoptysis (HP:0002105)2.32479836
84Deep palmar crease (HP:0006191)2.31335207
85Delayed CNS myelination (HP:0002188)2.31044580
86Chest pain (HP:0100749)2.29728595
87Gastrointestinal infarctions (HP:0005244)2.29323244
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28809027
89Pulmonary infiltrates (HP:0002113)2.28619469
90Abnormality of glycolipid metabolism (HP:0010969)2.28469386
91Abnormality of liposaccharide metabolism (HP:0010968)2.28469386
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.28469386
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28339895
94Cerebral edema (HP:0002181)2.25448919
95Lymphopenia (HP:0001888)2.21570628
96Annular pancreas (HP:0001734)2.21266738
97Prolonged bleeding time (HP:0003010)2.20133000
98Late onset (HP:0003584)2.19012568
99Abnormality of polysaccharide metabolism (HP:0011012)2.16038580
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16038580
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16038580
102Neonatal onset (HP:0003623)2.15943505
103Tetraplegia (HP:0002445)2.14654529
104Abnormality of methionine metabolism (HP:0010901)2.13745418
105Hand muscle atrophy (HP:0009130)2.12412927
106Spastic diplegia (HP:0001264)2.12302684
107Increased serum ferritin (HP:0003281)2.11974943
108Testicular neoplasm (HP:0010788)2.10103591
109Abnormality of serum amino acid levels (HP:0003112)2.09805709
110Global brain atrophy (HP:0002283)2.09340180
111Gastrointestinal stroma tumor (HP:0100723)2.09220997
112Spontaneous hematomas (HP:0007420)2.08610546
113Irritability (HP:0000737)2.07956008
114Status epilepticus (HP:0002133)2.07854817
115Broad face (HP:0000283)2.07706813
116Hyperbilirubinemia (HP:0002904)2.06274063
117Supranuclear gaze palsy (HP:0000605)2.03568508
118Abnormality of pyrimidine metabolism (HP:0004353)2.01959001
119Torticollis (HP:0000473)1.99998904
120Cerebral aneurysm (HP:0004944)1.99961871
121Spinal canal stenosis (HP:0003416)1.99376338
122Cheilitis (HP:0100825)1.98893214
123Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98363809
124Hypertensive crisis (HP:0100735)1.97281650
125Malnutrition (HP:0004395)1.97144779
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.97042658
127Focal dystonia (HP:0004373)1.96512009
128Conjugated hyperbilirubinemia (HP:0002908)1.96215384
129Morphological abnormality of the pyramidal tract (HP:0002062)1.96213312
130Craniofacial dystonia (HP:0012179)1.94178785
131Oligodontia (HP:0000677)1.93557546
132Amblyopia (HP:0000646)1.93414734
133Mucopolysacchariduria (HP:0008155)1.90700542
134Urinary glycosaminoglycan excretion (HP:0003541)1.90700542
135Lethargy (HP:0001254)1.90353059
136Loss of speech (HP:0002371)1.88076295
137Keratoconjunctivitis (HP:0001096)1.85764876
138Restrictive lung disease (HP:0002091)1.85653500
139Stridor (HP:0010307)1.85516581
140Hemorrhage of the eye (HP:0011885)1.85450457
141Keratoconjunctivitis sicca (HP:0001097)1.85149788
142Cerebral inclusion bodies (HP:0100314)1.84819724
143Pulmonary embolism (HP:0002204)1.84811064
144Hypoglycemic seizures (HP:0002173)1.84626553
145Distal upper limb amyotrophy (HP:0007149)1.84312342
146Upper limb amyotrophy (HP:0009129)1.84312342
147Delusions (HP:0000746)1.84266650
148Emphysema (HP:0002097)1.83333699
149Abnormality of nucleobase metabolism (HP:0010932)1.82829849
150Papilloma (HP:0012740)1.82717678
151Verrucae (HP:0200043)1.82717678
152Steatorrhea (HP:0002570)1.82032362
153J-shaped sella turcica (HP:0002680)1.81828586
154Episodic fever (HP:0001954)1.81721068
155Spontaneous abortion (HP:0005268)1.80227495
156Thrombocytosis (HP:0001894)1.80088700
157Back pain (HP:0003418)1.78939596
158Nasal polyposis (HP:0100582)1.78438650
159Hyperinsulinemic hypoglycemia (HP:0000825)1.78146743
160Neuronal loss in central nervous system (HP:0002529)1.78037450
161Alveolar cell carcinoma (HP:0006519)1.76669022
162Urticaria (HP:0001025)1.76461228
163Supernumerary nipples (HP:0002558)1.75900319
164Epistaxis (HP:0000421)1.75473549
165Abnormality of the nasal mucosa (HP:0000433)1.74569876
166Abnormality of purine metabolism (HP:0004352)1.73265273
167Pseudobulbar signs (HP:0002200)1.73234871
168Abnormality of the pleura (HP:0002103)1.73173943
169Abnormality of the endocardium (HP:0004306)1.73009945
170Acrocyanosis (HP:0001063)1.72593241
171Poor suck (HP:0002033)1.71600237
172Hypercholesterolemia (HP:0003124)1.71379028
173Pheochromocytoma (HP:0002666)1.70827531
174Pointed chin (HP:0000307)1.70689916
175Abnormality of T cells (HP:0002843)1.70332368
176Polygenic inheritance (HP:0010982)1.69187355
177Granulocytopenia (HP:0001913)1.68950402
178Abnormal tarsal ossification (HP:0008369)1.68859059
179Abnormality of the aortic arch (HP:0012303)1.68654233
180Abnormality of the intrinsic pathway (HP:0010989)1.68603392
181Easy fatigability (HP:0003388)1.68603040
182Delayed myelination (HP:0012448)1.67638628
183Visual hallucinations (HP:0002367)1.66829253
184Restlessness (HP:0000711)1.66665614
185Rectal prolapse (HP:0002035)1.66383851
186Death in childhood (HP:0003819)1.66217416
187Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.63099807
188Impaired pain sensation (HP:0007328)1.61252760
189Abnormality of pain sensation (HP:0010832)1.61252760
190Patent foramen ovale (HP:0001655)1.61117120
191Polycythemia (HP:0001901)1.60856656
192Neoplasm of the tracheobronchial system (HP:0100552)1.60824097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD45.00540464
2RIPK14.10025077
3EEF2K4.03922791
4MAP4K13.55076973
5DAPK23.00241176
6DYRK32.78335487
7BCKDK2.55758745
8PRPF4B2.54558081
9MARK12.41919289
10MAP3K132.37548011
11TNK22.33087239
12DYRK22.32568698
13MAPKAPK32.32465299
14MAP2K32.27791066
15MAP3K42.21187819
16BCR2.18301460
17RIPK42.18107383
18MAP3K102.16096064
19MAP3K92.14419143
20MAP3K22.11740270
21DYRK1B2.05319201
22IRAK41.87418908
23MARK21.74009327
24PRKD31.72598326
25BTK1.67380069
26IRAK31.63775923
27TYK21.63599846
28LATS21.61002107
29SMG11.60586524
30FER1.58389291
31BLK1.57652666
32MAP2K41.57180985
33CAMKK11.56998161
34MAP3K71.50923655
35PRKD21.46896322
36CDK41.44389358
37MAPK151.41875930
38AURKA1.39880202
39NEK21.39793801
40FES1.34936599
41CDK121.34907664
42CSK1.32485939
43MINK11.31325495
44ZAP701.30601925
45ICK1.28928442
46PAK31.28377946
47JAK31.27687715
48ITK1.27663601
49IKBKE1.26129524
50WNK31.24152184
51KSR21.22653883
52RPS6KB11.20686605
53BUB11.19615927
54CDC42BPA1.18009889
55UHMK11.18002342
56EPHA21.17765807
57TBK11.17268589
58FGFR41.15682947
59TESK11.14555182
60SYK1.13746491
61CAMK1D1.11589840
62MAP3K141.10086289
63RPS6KC11.09913337
64RPS6KL11.09913337
65SIK11.06773738
66TAOK11.04839873
67CSF1R1.03913910
68RPS6KA61.03707160
69IRAK21.02570678
70MAP2K61.01948163
71PDK11.00417497
72ARAF1.00213644
73PASK0.98913687
74TRIB30.98809670
75IKBKB0.97998437
76PAK60.97488636
77HCK0.95503259
78CAMK2G0.95401226
79PDPK10.94973620
80MAP3K110.94721085
81NTRK20.94287032
82LCK0.90307582
83CAMK2D0.90126688
84PRKCI0.89293298
85MAP3K10.86963754
86KIT0.86899819
87LRRK20.86009145
88RPS6KA20.84193877
89FGR0.82805834
90PDK30.82626617
91PDK40.82626617
92TYRO30.82371141
93BMX0.81197175
94TXK0.80983453
95MAPK120.80420750
96MAP3K30.80353627
97RPS6KB20.79772289
98LYN0.79396162
99BRAF0.79075432
100CAMKK20.78700724
101MAP2K70.77588996
102STK160.77086762
103PRKCZ0.74499400
104KSR10.74435895
105ERBB40.72642664
106SIK20.72427230
107CDK11A0.71575702
108CSNK1G20.70991051
109MAPK110.70906043
110MAP3K60.69318000
111NME20.69058079
112GSK3A0.68885334
113TESK20.67720243
114CSNK1G30.66685873
115MATK0.66518380
116ACVR1B0.66205286
117EPHA40.65553143
118MAPK130.65276648
119PNCK0.65015353
120PTK20.63829210
121CDK60.63025897
122ERN10.62756387
123CDK50.62347434
124FGFR30.61663935
125MAP2K20.61629991
126NTRK10.60568703
127MTOR0.59986965
128PRKCH0.59407523
129CDK190.59239700
130PHKG10.58539051
131PHKG20.58539051
132CHUK0.57202181
133DYRK1A0.56954871
134CAMK1G0.55929135
135TTN0.55392284
136CAMK10.55353171
137STK110.54473395
138AURKB0.54128022
139PRKCQ0.53944536
140WNK40.53923949
141CDK140.53793007
142TAOK20.53773326
143NEK10.53449076
144CDK150.52953296
145CAMK40.52363248
146ABL20.51852644
147MARK30.51717055
148EPHB10.51623444
149SGK30.51437427
150SCYL20.51254272
151FGFR20.50160699
152CDK180.48902180
153KDR0.45779945
154GRK60.45298092
155PRKAA10.44551867
156MAPK70.43681845
157LMTK20.42886724
158TEC0.41752162
159MAPKAPK50.41563966
160PIM10.41436249
161CSNK1G10.41142651
162FYN0.39629136
163IRAK10.39610463
164SGK2230.39117796
165SGK4940.39117796
166PKN20.37371322
167NTRK30.35416341
168LIMK10.34504386
169ALK0.34126612
170RPS6KA10.33124050
171HIPK20.31912897
172AKT20.31480473
173PTK60.30938041
174PRKCG0.30247185

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.45853889
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.29245288
3Sulfur metabolism_Homo sapiens_hsa009203.16350615
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86279188
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85523024
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69997230
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62976459
8Butanoate metabolism_Homo sapiens_hsa006502.57871205
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47451775
10B cell receptor signaling pathway_Homo sapiens_hsa046622.46268355
11Other glycan degradation_Homo sapiens_hsa005112.36300132
12Arginine biosynthesis_Homo sapiens_hsa002202.35737133
13Primary immunodeficiency_Homo sapiens_hsa053402.34205296
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31507921
15Vitamin B6 metabolism_Homo sapiens_hsa007502.28987891
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.20265609
17Osteoclast differentiation_Homo sapiens_hsa043802.17965237
18Notch signaling pathway_Homo sapiens_hsa043302.15402520
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14411938
20Tryptophan metabolism_Homo sapiens_hsa003802.12893307
21Fatty acid degradation_Homo sapiens_hsa000712.09572267
22Acute myeloid leukemia_Homo sapiens_hsa052212.07783376
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.05314586
24Leishmaniasis_Homo sapiens_hsa051401.88318217
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87549267
26VEGF signaling pathway_Homo sapiens_hsa043701.86093722
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.84271239
28T cell receptor signaling pathway_Homo sapiens_hsa046601.83516292
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77829212
30Folate biosynthesis_Homo sapiens_hsa007901.76163772
31Selenocompound metabolism_Homo sapiens_hsa004501.75897545
32Pyruvate metabolism_Homo sapiens_hsa006201.73821238
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73607061
34Propanoate metabolism_Homo sapiens_hsa006401.72161530
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69305327
36Graft-versus-host disease_Homo sapiens_hsa053321.64842291
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62022458
38Allograft rejection_Homo sapiens_hsa053301.61756550
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59343780
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57449867
41Sulfur relay system_Homo sapiens_hsa041221.56753535
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.53291611
43Complement and coagulation cascades_Homo sapiens_hsa046101.47963081
44beta-Alanine metabolism_Homo sapiens_hsa004101.47797313
45Bile secretion_Homo sapiens_hsa049761.46017199
46Biosynthesis of amino acids_Homo sapiens_hsa012301.44930165
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.43615900
48Autoimmune thyroid disease_Homo sapiens_hsa053201.43374470
49Fatty acid metabolism_Homo sapiens_hsa012121.42796840
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40908746
51Tuberculosis_Homo sapiens_hsa051521.40104637
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37875483
53Steroid biosynthesis_Homo sapiens_hsa001001.37607046
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.37516916
55PPAR signaling pathway_Homo sapiens_hsa033201.37087632
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.34697240
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.34290307
58Carbon metabolism_Homo sapiens_hsa012001.33267688
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32508189
60Chronic myeloid leukemia_Homo sapiens_hsa052201.32113346
61Retinol metabolism_Homo sapiens_hsa008301.31350885
62Histidine metabolism_Homo sapiens_hsa003401.29684439
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27933403
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27321151
65Peroxisome_Homo sapiens_hsa041461.25845577
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24073719
67NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23472848
68TNF signaling pathway_Homo sapiens_hsa046681.23388945
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.22558886
70Toxoplasmosis_Homo sapiens_hsa051451.20946430
71Chemokine signaling pathway_Homo sapiens_hsa040621.19827696
72Chemical carcinogenesis_Homo sapiens_hsa052041.19615459
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19556006
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18998920
75Fat digestion and absorption_Homo sapiens_hsa049751.18581836
76Phospholipase D signaling pathway_Homo sapiens_hsa040721.18126807
77Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17708108
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16607310
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14491156
80Phenylalanine metabolism_Homo sapiens_hsa003601.13727999
81Measles_Homo sapiens_hsa051621.13163038
82Influenza A_Homo sapiens_hsa051641.12806063
83Type I diabetes mellitus_Homo sapiens_hsa049401.08996742
84Lysosome_Homo sapiens_hsa041421.08722697
85Inositol phosphate metabolism_Homo sapiens_hsa005621.06148735
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06067374
87Choline metabolism in cancer_Homo sapiens_hsa052311.05872737
88Bladder cancer_Homo sapiens_hsa052191.05376671
89GnRH signaling pathway_Homo sapiens_hsa049121.05152443
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01190088
91Hepatitis C_Homo sapiens_hsa051600.98603941
92Hematopoietic cell lineage_Homo sapiens_hsa046400.98324595
93ErbB signaling pathway_Homo sapiens_hsa040120.97960776
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95688803
95Prolactin signaling pathway_Homo sapiens_hsa049170.95469307
96Herpes simplex infection_Homo sapiens_hsa051680.94591957
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.91384325
98Hepatitis B_Homo sapiens_hsa051610.90992712
99Asthma_Homo sapiens_hsa053100.90456386
100Pancreatic cancer_Homo sapiens_hsa052120.88822386
101Platelet activation_Homo sapiens_hsa046110.88799980
102Tyrosine metabolism_Homo sapiens_hsa003500.88011422
103Endometrial cancer_Homo sapiens_hsa052130.87732638
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87338456
105Antigen processing and presentation_Homo sapiens_hsa046120.87197738
106Arginine and proline metabolism_Homo sapiens_hsa003300.86738827
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85440631
108Malaria_Homo sapiens_hsa051440.84810339
109Viral myocarditis_Homo sapiens_hsa054160.83883789
110Fatty acid elongation_Homo sapiens_hsa000620.83882480
111One carbon pool by folate_Homo sapiens_hsa006700.82597205
112Apoptosis_Homo sapiens_hsa042100.82469206
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81429461
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79585301
115MAPK signaling pathway_Homo sapiens_hsa040100.79216865
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.78519719
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.77086925
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76575242
119Caffeine metabolism_Homo sapiens_hsa002320.76197490
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.75428088
121Type II diabetes mellitus_Homo sapiens_hsa049300.74491253
122Renal cell carcinoma_Homo sapiens_hsa052110.74226555
123Dorso-ventral axis formation_Homo sapiens_hsa043200.72543219
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72268008
125ABC transporters_Homo sapiens_hsa020100.70779929
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70631863
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69950049
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69489117
129FoxO signaling pathway_Homo sapiens_hsa040680.67107255
130HTLV-I infection_Homo sapiens_hsa051660.67056907
131Colorectal cancer_Homo sapiens_hsa052100.66422654
132Pentose phosphate pathway_Homo sapiens_hsa000300.65533620
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64250764
134Salmonella infection_Homo sapiens_hsa051320.60613235
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60495036
136Endocytosis_Homo sapiens_hsa041440.60197922
137African trypanosomiasis_Homo sapiens_hsa051430.59721321
138Glycerolipid metabolism_Homo sapiens_hsa005610.59227025
139Lysine degradation_Homo sapiens_hsa003100.58668981
140Glioma_Homo sapiens_hsa052140.57981178
141Glucagon signaling pathway_Homo sapiens_hsa049220.57955309
142Estrogen signaling pathway_Homo sapiens_hsa049150.55732707
143Rap1 signaling pathway_Homo sapiens_hsa040150.55394017
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54455381
145Viral carcinogenesis_Homo sapiens_hsa052030.53124407
146Olfactory transduction_Homo sapiens_hsa047400.52700149
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52054966
148Glutathione metabolism_Homo sapiens_hsa004800.51945938
149Alcoholism_Homo sapiens_hsa050340.51736190
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51584706
151Starch and sucrose metabolism_Homo sapiens_hsa005000.51176247
152Epstein-Barr virus infection_Homo sapiens_hsa051690.50303767
153Non-small cell lung cancer_Homo sapiens_hsa052230.50283320
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49531337
155Rheumatoid arthritis_Homo sapiens_hsa053230.49305838
156Phagosome_Homo sapiens_hsa041450.46534353
157Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46365663
158Pertussis_Homo sapiens_hsa051330.46246257
159Ras signaling pathway_Homo sapiens_hsa040140.44998385
160Insulin secretion_Homo sapiens_hsa049110.44115514
161Systemic lupus erythematosus_Homo sapiens_hsa053220.43382119
162Metabolic pathways_Homo sapiens_hsa011000.42851572
163Adipocytokine signaling pathway_Homo sapiens_hsa049200.40176105
164Insulin resistance_Homo sapiens_hsa049310.37815844
165AMPK signaling pathway_Homo sapiens_hsa041520.37763671
166Prion diseases_Homo sapiens_hsa050200.36184232
167Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34733381
168Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33925283
169GABAergic synapse_Homo sapiens_hsa047270.31624255
170Vitamin digestion and absorption_Homo sapiens_hsa049770.31478983
171Synaptic vesicle cycle_Homo sapiens_hsa047210.31311977
172Cocaine addiction_Homo sapiens_hsa050300.31075399
173Insulin signaling pathway_Homo sapiens_hsa049100.26983983
174Glycerophospholipid metabolism_Homo sapiens_hsa005640.26827402
175Parkinsons disease_Homo sapiens_hsa050120.21254508
176Glutamatergic synapse_Homo sapiens_hsa047240.20768729
177Gap junction_Homo sapiens_hsa045400.20657404
178Regulation of autophagy_Homo sapiens_hsa041400.18861802
179Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17326339
180Fatty acid biosynthesis_Homo sapiens_hsa000610.17145766
181mTOR signaling pathway_Homo sapiens_hsa041500.16938612
182Oocyte meiosis_Homo sapiens_hsa041140.16156438
183Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15318533
184Amphetamine addiction_Homo sapiens_hsa050310.13729211
185Staphylococcus aureus infection_Homo sapiens_hsa051500.13052603
186Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11533820
187Dopaminergic synapse_Homo sapiens_hsa047280.10378947

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