CAPN11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.95071826
2sperm-egg recognition (GO:0035036)9.86901644
3acrosome reaction (GO:0007340)9.67665924
4multicellular organism reproduction (GO:0032504)9.55413918
5acrosome assembly (GO:0001675)9.49702891
6motile cilium assembly (GO:0044458)9.15497408
7binding of sperm to zona pellucida (GO:0007339)9.07104057
8epithelial cilium movement (GO:0003351)8.95188991
9cell-cell recognition (GO:0009988)8.87798643
10plasma membrane fusion (GO:0045026)8.69512940
11spermatid development (GO:0007286)8.68212830
12regulation of cilium movement (GO:0003352)8.62558422
13cell wall macromolecule catabolic process (GO:0016998)8.48270590
14cell wall macromolecule metabolic process (GO:0044036)8.48270590
15male meiosis (GO:0007140)8.27706839
16protein neddylation (GO:0045116)8.09934349
17synaptonemal complex organization (GO:0070193)8.00547173
18reproduction (GO:0000003)7.83187728
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.80258089
20synaptonemal complex assembly (GO:0007130)7.78088948
21cilium movement (GO:0003341)7.73009770
22thrombin receptor signaling pathway (GO:0070493)6.69505343
23male meiosis I (GO:0007141)6.54645193
24single fertilization (GO:0007338)6.48103872
25neutrophil activation involved in immune response (GO:0002283)6.28068946
26sperm capacitation (GO:0048240)6.11793155
27microtubule depolymerization (GO:0007019)6.00175622
28DNA methylation involved in gamete generation (GO:0043046)5.92652112
29negative regulation of inclusion body assembly (GO:0090084)5.81346098
30meiosis I (GO:0007127)5.67095062
31fertilization (GO:0009566)5.64786356
32spermatogenesis (GO:0007283)5.56970996
33male gamete generation (GO:0048232)5.54952098
34regulation of platelet activation (GO:0010543)5.44539162
35adenosine receptor signaling pathway (GO:0001973)5.41053559
36chromosome organization involved in meiosis (GO:0070192)5.40832313
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.37441988
38meiotic nuclear division (GO:0007126)5.34402241
39negative regulation of thymocyte apoptotic process (GO:0070244)5.27966206
40gamete generation (GO:0007276)5.11900676
41regulation of microtubule-based movement (GO:0060632)5.00246116
42germ cell development (GO:0007281)4.98320888
43blood coagulation, intrinsic pathway (GO:0007597)4.97181917
44positive regulation of endothelial cell differentiation (GO:0045603)4.95820917
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.91470975
46seminiferous tubule development (GO:0072520)4.89386718
47regulation of inclusion body assembly (GO:0090083)4.84642310
48monoubiquitinated protein deubiquitination (GO:0035520)4.76667845
49meiotic cell cycle (GO:0051321)4.72980925
50ventricular system development (GO:0021591)4.70689069
51organic cation transport (GO:0015695)4.69503627
52regulation of integrin-mediated signaling pathway (GO:2001044)4.66685198
53negative regulation of norepinephrine secretion (GO:0010700)4.65134083
54regulation of platelet aggregation (GO:0090330)4.57863130
55lipoxygenase pathway (GO:0019372)4.55249222
56polyamine biosynthetic process (GO:0006596)4.53995604
57negative regulation of platelet activation (GO:0010544)4.53560526
58platelet aggregation (GO:0070527)4.49733380
59calcium ion-dependent exocytosis (GO:0017156)4.39629639
60angiogenesis involved in wound healing (GO:0060055)4.39426858
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.36344537
62leukocyte migration involved in inflammatory response (GO:0002523)4.24372860
63negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.23355714
64negative regulation of heart rate (GO:0010459)4.17100233
65G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.11113155
66purinergic nucleotide receptor signaling pathway (GO:0035590)4.08253506
67cell recognition (GO:0008037)4.06626918
68microtubule severing (GO:0051013)4.02651008
69low-density lipoprotein particle remodeling (GO:0034374)3.99060827
70left/right pattern formation (GO:0060972)3.98383893
71multicellular organismal reproductive process (GO:0048609)3.97581626
72response to pheromone (GO:0019236)3.97345012
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.95883900
74endothelium development (GO:0003158)3.95775474
75genitalia morphogenesis (GO:0035112)3.90369627
76gene silencing by RNA (GO:0031047)3.89758681
77negative regulation of T cell apoptotic process (GO:0070233)3.87188209
78regulation of Golgi to plasma membrane protein transport (GO:0042996)3.86313198
79neutrophil activation (GO:0042119)3.83124058
80meiotic cell cycle process (GO:1903046)3.80677377
81negative regulation of homotypic cell-cell adhesion (GO:0034111)3.80580273
82protein localization to cilium (GO:0061512)3.79808015
83regulation of integrin activation (GO:0033623)3.71104870
84spermatid nucleus differentiation (GO:0007289)3.67631066
85regulation of endothelial cell differentiation (GO:0045601)3.64865049
86purinergic receptor signaling pathway (GO:0035587)3.59125795
87chromosome condensation (GO:0030261)3.55260225
88positive regulation of mast cell activation (GO:0033005)3.52887701
89pyrimidine nucleotide catabolic process (GO:0006244)3.51628960
90platelet degranulation (GO:0002576)3.48018961
91chaperone-mediated protein complex assembly (GO:0051131)3.47429936
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47323431
93DNA packaging (GO:0006323)3.46133778
94leukocyte degranulation (GO:0043299)3.43412219
95regulation of meiosis I (GO:0060631)3.42883894
96regulation of cholesterol efflux (GO:0010874)3.38284318
97regulation of norepinephrine secretion (GO:0014061)3.36577137
98G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.36349220
99nucleus organization (GO:0006997)3.31599494
100glycerol ether metabolic process (GO:0006662)3.31406658
101regulation of spindle checkpoint (GO:0090231)3.30677603
102Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29367397
103pyrimidine nucleoside catabolic process (GO:0046135)3.28637737
104granulocyte activation (GO:0036230)3.27531583
105extracellular fibril organization (GO:0043206)3.25893989
106ether lipid metabolic process (GO:0046485)3.24341320
107positive regulation of receptor recycling (GO:0001921)3.23007907
108protein polyglutamylation (GO:0018095)3.22974059
109positive regulation of cAMP-mediated signaling (GO:0043950)3.22801128
110microtubule polymerization or depolymerization (GO:0031109)3.22306488
111multicellular organismal development (GO:0007275)3.19437233
112regulation of MHC class II biosynthetic process (GO:0045346)3.18420140
113regulation of female receptivity (GO:0045924)3.15551540
114platelet activation (GO:0030168)3.15548876
115autophagic vacuole fusion (GO:0000046)3.14758657
116regulation of macrophage derived foam cell differentiation (GO:0010743)3.14625072
117cellular biogenic amine biosynthetic process (GO:0042401)3.14325479
118negative regulation of neural precursor cell proliferation (GO:2000178)3.13239649
119regulation of lipoprotein metabolic process (GO:0050746)3.12878815
120negative regulation of appetite (GO:0032099)3.11632625
121negative regulation of response to food (GO:0032096)3.11632625
122carnitine transmembrane transport (GO:1902603)3.11173999
123amino-acid betaine transport (GO:0015838)3.10008929
124carnitine transport (GO:0015879)3.10008929
125positive regulation of systemic arterial blood pressure (GO:0003084)3.08522294
126fibril organization (GO:0097435)3.08327107
127nuclear pore complex assembly (GO:0051292)3.05064101
128mast cell activation involved in immune response (GO:0002279)3.04259801
129mast cell degranulation (GO:0043303)3.04259801
130positive regulation of B cell differentiation (GO:0045579)3.04199657
131negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.03798192
132synapsis (GO:0007129)3.03386430
133female mating behavior (GO:0060180)3.02861477
134positive regulation of protein homodimerization activity (GO:0090073)3.02231285
135regulation of centriole replication (GO:0046599)3.01977335
136ether metabolic process (GO:0018904)3.01693215
137microtubule-based movement (GO:0007018)3.01419276
138axoneme assembly (GO:0035082)3.01413068
139peptide catabolic process (GO:0043171)3.00444211
140positive regulation of macrophage differentiation (GO:0045651)2.98893445
141cellular biogenic amine catabolic process (GO:0042402)2.98137947
142amine catabolic process (GO:0009310)2.98137947
143amine biosynthetic process (GO:0009309)2.96873683
144homotypic cell-cell adhesion (GO:0034109)2.96229944
145megakaryocyte development (GO:0035855)2.96125891
146protein localization to chromosome, centromeric region (GO:0071459)2.95693839
147gene silencing (GO:0016458)2.94445749
148platelet formation (GO:0030220)2.94008909
149intraciliary transport (GO:0042073)2.93285001
150mitotic sister chromatid cohesion (GO:0007064)2.92902328
151polyol catabolic process (GO:0046174)2.89122355
152positive regulation of Rho protein signal transduction (GO:0035025)2.88408522
153regulation of inositol phosphate biosynthetic process (GO:0010919)2.88057569
154mitochondrial calcium ion transport (GO:0006851)2.87104441
155negative regulation of stress fiber assembly (GO:0051497)2.86574303
156deoxyribonucleotide catabolic process (GO:0009264)2.85800213
157histone exchange (GO:0043486)2.81867321
158platelet dense granule organization (GO:0060155)2.79572993
159regulation of receptor recycling (GO:0001919)2.79193188
160polyamine metabolic process (GO:0006595)2.78969200
161negative regulation of T-helper cell differentiation (GO:0045623)2.78634606
162negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78634606
163cyclooxygenase pathway (GO:0019371)2.78426044
164alditol metabolic process (GO:0019400)2.76079956
165regulation of histone H3-K9 methylation (GO:0051570)2.75894689
166regulation of mast cell degranulation (GO:0043304)2.75767042
167deoxyribose phosphate catabolic process (GO:0046386)2.74587929
168fatty acid elongation (GO:0030497)2.74343244
169regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74143095
170regulation of homotypic cell-cell adhesion (GO:0034110)2.72979084
171monoamine transport (GO:0015844)2.72899764
172deoxyribose phosphate biosynthetic process (GO:0046385)2.72573634
1732-deoxyribonucleotide biosynthetic process (GO:0009265)2.72573634
174regulation of mast cell activation (GO:0033003)2.72533035
175cilium organization (GO:0044782)2.70651525
176sister chromatid cohesion (GO:0007062)2.61859938
177DNA methylation (GO:0006306)2.60036252
178DNA alkylation (GO:0006305)2.60036252
179regulation of response to osmotic stress (GO:0047484)2.57561702
180protein refolding (GO:0042026)2.57440034
181cilium assembly (GO:0042384)2.56966427
182nucleoside diphosphate phosphorylation (GO:0006165)2.56668400
183negative regulation of organelle assembly (GO:1902116)2.54922997
184DNA replication-dependent nucleosome assembly (GO:0006335)2.52154632
185DNA replication-dependent nucleosome organization (GO:0034723)2.52154632
186nuclear pore organization (GO:0006999)2.51380454
187single strand break repair (GO:0000012)2.50634454
188regulation of chromatin binding (GO:0035561)2.50193160
189translesion synthesis (GO:0019985)2.48146704
190centriole assembly (GO:0098534)2.46954452
191cilium or flagellum-dependent cell motility (GO:0001539)14.0305741
192fusion of sperm to egg plasma membrane (GO:0007342)11.5724267
193sperm motility (GO:0030317)11.1857116
194axonemal dynein complex assembly (GO:0070286)10.1352782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.60954712
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.28634075
3EZH2_22144423_ChIP-Seq_EOC_Human4.07354491
4SCL_19346495_ChIP-Seq_HPC-7_Human3.76724867
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.21139280
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16481704
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15317835
8GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.00730494
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97967382
10GATA1_19941826_ChIP-Seq_K562_Human2.84809111
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.54002649
12GATA2_19941826_ChIP-Seq_K562_Human2.39817638
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.29778347
14SPI1_23127762_ChIP-Seq_K562_Human2.29614030
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.24763252
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17052809
17GATA1_22383799_ChIP-Seq_G1ME_Mouse2.16787833
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13694677
19GATA1_19941827_ChIP-Seq_MEL_Mouse2.09754519
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.04357869
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.01352821
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7846153
23HTT_18923047_ChIP-ChIP_STHdh_Human1.98023990
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.97203201
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.96053088
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95777162
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.89728146
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84879327
29SPI1_20517297_ChIP-Seq_HL60_Human1.79645195
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79081954
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74059079
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71778508
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69473254
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68917950
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68493526
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65668840
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63480730
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59826911
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57723421
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55153574
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53852941
42ZNF274_21170338_ChIP-Seq_K562_Hela1.49410567
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48720185
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48591139
45* STAT1_17558387_ChIP-Seq_HELA_Human1.47123515
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46881677
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.46664604
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46389356
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.46057015
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43889749
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41023266
52GATA1_22025678_ChIP-Seq_K562_Human1.40513045
53SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40047735
54* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39646666
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.39510648
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38675122
57FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38145208
58MYB_26560356_Chip-Seq_TH2_Human1.37070675
59UTX_26944678_Chip-Seq_JUKART_Human1.36261465
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.34533499
61P300_27268052_Chip-Seq_Bcells_Human1.32882571
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32418213
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31776227
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.30456941
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27704172
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.27447662
67SALL4_22934838_ChIP-ChIP_CD34+_Human1.26999127
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26641323
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26540310
70SPI1_23547873_ChIP-Seq_NB4_Human1.26450908
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26124847
72* STAT1_20625510_ChIP-Seq_HELA_Human1.25865259
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24743068
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.24576828
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24143346
76GATA1_19941827_ChIP-Seq_MEL86_Mouse1.23210802
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22994484
78* GATA3_21878914_ChIP-Seq_MCF-7_Human1.22442812
79KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21005478
80VDR_22108803_ChIP-Seq_LS180_Human1.20973562
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20805697
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19413898
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.18886219
84CEBPB_22108803_ChIP-Seq_LS180_Human1.17654829
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17575074
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.17026874
87P53_21459846_ChIP-Seq_SAOS-2_Human1.16822967
88* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16386499
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15375688
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14746123
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13947923
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.12791201
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12098414
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11960032
95PHF8_20622854_ChIP-Seq_HELA_Human1.11780686
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.11744612
97SPI1_26923725_Chip-Seq_HPCs_Mouse1.11562994
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11338980
99IRF1_19129219_ChIP-ChIP_H3396_Human1.10915545
100FLI1_21867929_ChIP-Seq_CD8_Mouse1.10902238
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10530765
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09323814
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.09161065
104REST_21632747_ChIP-Seq_MESCs_Mouse1.09025775
105RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08633913
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07353551
107NCOR1_26117541_ChIP-Seq_K562_Human1.06579818
108RUNX_20019798_ChIP-Seq_JUKART_Human1.06558654
109IGF1R_20145208_ChIP-Seq_DFB_Human1.06194175
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06136288
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.06098322
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05330421
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04824703
114NANOG_19829295_ChIP-Seq_ESCs_Human1.03672558
115SOX2_19829295_ChIP-Seq_ESCs_Human1.03672558
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03082241
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02661021
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02240018
119FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02167125
120BCOR_27268052_Chip-Seq_Bcells_Human1.00192809
121CBP_20019798_ChIP-Seq_JUKART_Human1.00127039
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00127039
123GATA3_27048872_Chip-Seq_THYMUS_Human1.00075454
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99964352
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99719306
126* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99690802
127MYB_26560356_Chip-Seq_TH1_Human0.98620437
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96195312
129RBPJ_21746931_ChIP-Seq_IB4_Human0.96043520
130GF1_26923725_Chip-Seq_HPCs_Mouse0.96003170
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95998510
132ERG_20517297_ChIP-Seq_VCAP_Human0.95194927
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95102378
134* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95075875
135E2F1_20622854_ChIP-Seq_HELA_Human0.94610168
136* CTCF_26484167_Chip-Seq_Bcells_Mouse0.94595287
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94498503
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.94380248
139* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94311879
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94009779
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93136686
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92162188
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92091163
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.91309088
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90778590
146* SOX2_21211035_ChIP-Seq_LN229_Human0.90762115
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89224937
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88970664
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88646934
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.88646934
151OCT4_20526341_ChIP-Seq_ESCs_Human0.88605131
152BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88306006
153RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87608041
154TAF2_19829295_ChIP-Seq_ESCs_Human0.87383769
155GATA3_26560356_Chip-Seq_TH2_Human0.87338755
156CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87134518
157NANOG_20526341_ChIP-Seq_ESCs_Human0.86798786
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.86222210
159LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85909545
160GATA6_21074721_ChIP-Seq_CACO-2_Human0.85716842
161MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85209361
162POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84372633
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84372633
164CTCF_20526341_ChIP-Seq_ESCs_Human0.83524347
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.83476039
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83272012
167PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83112188
168EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83017043
169RARB_24833708_ChIP-Seq_LIVER_Mouse0.81400329
170GATA3_26560356_Chip-Seq_TH1_Human0.80225528
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79880184
172ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79849330
173GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79821891
174NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78260017
175BCL6_27268052_Chip-Seq_Bcells_Human0.77242517
176OCT4_21477851_ChIP-Seq_ESCs_Mouse0.77073712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.74300977
2MP0003698_abnormal_male_reproductive5.57478904
3MP0001929_abnormal_gametogenesis5.23846825
4MP0008877_abnormal_DNA_methylation4.94847519
5MP0008004_abnormal_stomach_pH4.02313890
6MP0002210_abnormal_sex_determination3.71287586
7MP0002653_abnormal_ependyma_morphology3.58482957
8MP0003724_increased_susceptibility_to3.39169361
9MP0001145_abnormal_male_reproductive3.12588882
10MP0002161_abnormal_fertility/fecundity3.10405123
11MP0005083_abnormal_biliary_tract2.92025751
12MP0000653_abnormal_sex_gland2.73522582
13MP0000465_gastrointestinal_hemorrhage2.66887672
14MP0008057_abnormal_DNA_replication2.28649279
15MP0000343_altered_response_to2.27097852
16MP0005167_abnormal_blood-brain_barrier2.25358572
17MP0008058_abnormal_DNA_repair2.10539159
18MP0001835_abnormal_antigen_presentation2.05252538
19MP0002736_abnormal_nociception_after2.03790113
20MP0000230_abnormal_systemic_arterial2.01040233
21MP0005410_abnormal_fertilization13.6172304
22MP0002160_abnormal_reproductive_system1.96126552
23MP0005084_abnormal_gallbladder_morpholo1.95712975
24MP0001879_abnormal_lymphatic_vessel1.95391137
25MP0003111_abnormal_nucleus_morphology1.94893093
26MP0004084_abnormal_cardiac_muscle1.91147862
27MP0005671_abnormal_response_to1.88287895
28MP0010094_abnormal_chromosome_stability1.86928147
29MP0003828_pulmonary_edema1.79032687
30MP0003638_abnormal_response/metabolism_1.76442006
31MP0005058_abnormal_lysosome_morphology1.70887731
32MP0008775_abnormal_heart_ventricle1.70358123
33MP0003693_abnormal_embryo_hatching1.69753423
34MP0002148_abnormal_hypersensitivity_rea1.68461292
35MP0005670_abnormal_white_adipose1.63761082
36MP0005000_abnormal_immune_tolerance1.59934782
37MP0009697_abnormal_copulation1.59398463
38MP0008872_abnormal_physiological_respon1.57657386
39MP0003566_abnormal_cell_adhesion1.57017753
40MP0001545_abnormal_hematopoietic_system1.53892304
41MP0005397_hematopoietic_system_phenotyp1.53892304
42MP0005646_abnormal_pituitary_gland1.51061712
43MP0001968_abnormal_touch/_nociception1.46176793
44MP0003303_peritoneal_inflammation1.42440152
45MP0004036_abnormal_muscle_relaxation1.42183380
46MP0003646_muscle_fatigue1.38081022
47MP0010155_abnormal_intestine_physiology1.36839112
48MP0008007_abnormal_cellular_replicative1.36029457
49MP0000249_abnormal_blood_vessel1.33548396
50MP0003077_abnormal_cell_cycle1.28286361
51MP0004510_myositis1.27649139
52MP0003878_abnormal_ear_physiology1.27367317
53MP0005377_hearing/vestibular/ear_phenot1.27367317
54MP0005666_abnormal_adipose_tissue1.23479937
55MP0003075_altered_response_to1.23165470
56MP0002723_abnormal_immune_serum1.21064400
57MP0010368_abnormal_lymphatic_system1.20379110
58MP0002452_abnormal_antigen_presenting1.17752647
59MP0005623_abnormal_meninges_morphology1.16161757
60MP0002420_abnormal_adaptive_immunity1.15937301
61MP0009763_increased_sensitivity_to1.14661180
62MP0001819_abnormal_immune_cell1.14344664
63MP0009046_muscle_twitch1.13630835
64MP0001533_abnormal_skeleton_physiology1.12678701
65MP0008995_early_reproductive_senescence1.12346150
66MP0001800_abnormal_humoral_immune1.11232798
67MP0008874_decreased_physiological_sensi1.11184140
68MP0002102_abnormal_ear_morphology1.07402579
69MP0004808_abnormal_hematopoietic_stem1.05967246
70MP0009765_abnormal_xenobiotic_induced1.05045763
71MP0005165_increased_susceptibility_to1.04399994
72MP0005389_reproductive_system_phenotype1.02826656
73MP0005025_abnormal_response_to1.02255329
74MP0005647_abnormal_sex_gland1.02155817
75MP0004947_skin_inflammation0.99721657
76MP0002733_abnormal_thermal_nociception0.99600009
77MP0001663_abnormal_digestive_system0.99166681
78MP0004130_abnormal_muscle_cell0.97517452
79MP0009764_decreased_sensitivity_to0.95910177
80MP0002419_abnormal_innate_immunity0.95801436
81MP0006276_abnormal_autonomic_nervous0.95800755
82MP0009278_abnormal_bone_marrow0.95623268
83MP0001851_eye_inflammation0.95599279
84MP0003786_premature_aging0.95463212
85MP0005409_darkened_coat_color0.92837425
86MP0004147_increased_porphyrin_level0.92047547
87MP0004215_abnormal_myocardial_fiber0.91725965
88MP0003183_abnormal_peptide_metabolism0.91047493
89MP0003436_decreased_susceptibility_to0.89629507
90MP0010329_abnormal_lipoprotein_level0.89449523
91MP0001730_embryonic_growth_arrest0.85965227
92MP0001845_abnormal_inflammatory_respons0.85268945
93MP0000358_abnormal_cell_content/0.84991190
94MP0004957_abnormal_blastocyst_morpholog0.84979728
95MP0000858_altered_metastatic_potential0.83529705
96MP0004233_abnormal_muscle_weight0.83332237
97MP0002139_abnormal_hepatobiliary_system0.81118259
98MP0003172_abnormal_lysosome_physiology0.80213427
99MP0009642_abnormal_blood_homeostasis0.80015138
100MP0003866_abnormal_defecation0.79967448
101MP0005535_abnormal_body_temperature0.79343826
102MP0005387_immune_system_phenotype0.77041681
103MP0001790_abnormal_immune_system0.77041681
104MP0010307_abnormal_tumor_latency0.76804309
105MP0003806_abnormal_nucleotide_metabolis0.76541275
106MP0003699_abnormal_female_reproductive0.75092211
107MP0003718_maternal_effect0.74924416
108MP0001544_abnormal_cardiovascular_syste0.74640873
109MP0005385_cardiovascular_system_phenoty0.74640873
110MP0001905_abnormal_dopamine_level0.74533532
111MP0005365_abnormal_bile_salt0.73871775
112MP0002132_abnormal_respiratory_system0.73779297
113MP0003879_abnormal_hair_cell0.73386869
114MP0003136_yellow_coat_color0.71736994
115MP0001986_abnormal_taste_sensitivity0.70965999
116MP0005423_abnormal_somatic_nervous0.69364751
117MP0005166_decreased_susceptibility_to0.68612764
118MP0006138_congestive_heart_failure0.67964318
119MP0000313_abnormal_cell_death0.67347106
120MP0001764_abnormal_homeostasis0.66761197
121MP0000015_abnormal_ear_pigmentation0.66205702
122MP0008260_abnormal_autophagy0.63595414
123MP0003656_abnormal_erythrocyte_physiolo0.63428931
124MP0001119_abnormal_female_reproductive0.63282959
125MP0003011_delayed_dark_adaptation0.61484138
126MP0002282_abnormal_trachea_morphology0.59532239
127MP0001672_abnormal_embryogenesis/_devel0.57571657
128MP0005380_embryogenesis_phenotype0.57571657
129MP0002928_abnormal_bile_duct0.56655771
130MP0001984_abnormal_olfaction0.56652538
131MP0001293_anophthalmia0.55614753
132MP0000703_abnormal_thymus_morphology0.53664092
133MP0003115_abnormal_respiratory_system0.52855578
134MP0001765_abnormal_ion_homeostasis0.52688463
135MP0000569_abnormal_digit_pigmentation0.50890242
136MP0004019_abnormal_vitamin_homeostasis0.50299556
137MP0002398_abnormal_bone_marrow0.49984029
138MP0001697_abnormal_embryo_size0.49704720
139MP0002405_respiratory_system_inflammati0.49544578
140MP0000350_abnormal_cell_proliferation0.47383950
141MP0002080_prenatal_lethality0.45541576
142MP0000685_abnormal_immune_system0.44621359
143MP0004264_abnormal_extraembryonic_tissu0.43287895
144MP0005636_abnormal_mineral_homeostasis0.42760999
145MP0002084_abnormal_developmental_patter0.42563866
146MP0003984_embryonic_growth_retardation0.42448787
147MP0000689_abnormal_spleen_morphology0.41439128
148MP0003329_amyloid_beta_deposits0.39878841
149MP0002088_abnormal_embryonic_growth/wei0.39367915
150MP0002396_abnormal_hematopoietic_system0.38526493
151MP0002019_abnormal_tumor_incidence0.37124419
152MP0005391_vision/eye_phenotype0.35750326
153MP0009333_abnormal_splenocyte_physiolog0.35445932
154MP0005174_abnormal_tail_pigmentation0.35203166
155MP0005360_urolithiasis0.34961766
156MP0002269_muscular_atrophy0.33621606
157MP0002092_abnormal_eye_morphology0.33166877
158MP0002722_abnormal_immune_system0.33091980
159MP0003787_abnormal_imprinting0.32605575
160MP0003763_abnormal_thymus_physiology0.32561176
161MP0006036_abnormal_mitochondrial_physio0.32143890
162MP0001348_abnormal_lacrimal_gland0.32140695
163MP0002971_abnormal_brown_adipose0.32065574
164MP0002085_abnormal_embryonic_tissue0.32061667
165MP0002169_no_abnormal_phenotype0.32034229
166MP0001440_abnormal_grooming_behavior0.31865394
167MP0002086_abnormal_extraembryonic_tissu0.31690280
168MP0005451_abnormal_body_composition0.31664879
169MP0002873_normal_phenotype0.31499702
170MP0008961_abnormal_basal_metabolism0.31468876
171MP0009840_abnormal_foam_cell0.30721405
172MP0000716_abnormal_immune_system0.30092142
173MP0009115_abnormal_fat_cell0.30088563
174MP0002429_abnormal_blood_cell0.29905919

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)8.85553141
2Abnormal respiratory motile cilium physiology (HP:0012261)8.76046681
3Petechiae (HP:0000967)8.58522805
4Abnormal respiratory epithelium morphology (HP:0012253)8.54003394
5Abnormal respiratory motile cilium morphology (HP:0005938)8.54003394
6Increased mean platelet volume (HP:0011877)8.26201609
7Abnormal platelet volume (HP:0011876)7.79075260
8Rhinitis (HP:0012384)7.61038518
9Purpura (HP:0000979)7.54533387
10Epistaxis (HP:0000421)7.03919934
11Abnormal ciliary motility (HP:0012262)6.97359687
12Nasal polyposis (HP:0100582)6.76477047
13Infertility (HP:0000789)6.51740179
14Chronic bronchitis (HP:0004469)6.41905436
15Hyperlipoproteinemia (HP:0010980)5.87843572
16Abnormality of the nasal mucosa (HP:0000433)5.64858735
17Gingival bleeding (HP:0000225)5.24069238
18Impaired platelet aggregation (HP:0003540)4.89278376
19Abnormal platelet function (HP:0011869)4.89278376
20Bronchiectasis (HP:0002110)4.70175698
21Bronchitis (HP:0012387)4.46997860
22Spontaneous hematomas (HP:0007420)4.45191980
23Dyschromatopsia (HP:0007641)4.38388869
24Nephronophthisis (HP:0000090)4.21621260
25Impulsivity (HP:0100710)3.74239445
26Abnormality of the lower motor neuron (HP:0002366)3.72018292
27Hepatosplenomegaly (HP:0001433)3.67437445
28Male infertility (HP:0003251)3.65039757
29Abnormal pupillary function (HP:0007686)3.58432477
30Acanthocytosis (HP:0001927)3.54617916
31Paralysis (HP:0003470)3.52530501
32Recurrent otitis media (HP:0000403)3.52479500
33Poikilocytosis (HP:0004447)3.44094638
34Abnormality of the heme biosynthetic pathway (HP:0010472)3.40893978
35Recurrent sinusitis (HP:0011108)3.32428867
36Abnormal spermatogenesis (HP:0008669)3.29410405
37Abnormality of the renal medulla (HP:0100957)3.27154278
38Amyotrophic lateral sclerosis (HP:0007354)3.26408478
39Recurrent bronchitis (HP:0002837)3.17059476
40Abnormality of lateral ventricle (HP:0030047)3.16807146
41Abnormality of the vasculature of the conjunctiva (HP:0008054)3.04031094
42Stomatitis (HP:0010280)2.97863912
433-Methylglutaconic aciduria (HP:0003535)2.96137643
44Bruising susceptibility (HP:0000978)2.95933726
45Generalized aminoaciduria (HP:0002909)2.94337900
46Increased IgM level (HP:0003496)2.73372057
47Gonadotropin excess (HP:0000837)2.67363932
48Abnormality of the prostate (HP:0008775)2.63229207
49Abnormality of macrophages (HP:0004311)2.56644937
50Azoospermia (HP:0000027)2.54843715
51Elevated erythrocyte sedimentation rate (HP:0003565)2.45957319
52Joint hemorrhage (HP:0005261)2.45201709
53Joint swelling (HP:0001386)2.41597421
54Degeneration of anterior horn cells (HP:0002398)2.40694268
55Abnormality of the anterior horn cell (HP:0006802)2.40694268
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39327034
57Spontaneous abortion (HP:0005268)2.39291517
58Medial flaring of the eyebrow (HP:0010747)2.38417148
59Upper motor neuron abnormality (HP:0002127)2.37844096
60Decreased central vision (HP:0007663)2.37570355
61Tubulointerstitial nephritis (HP:0001970)2.36208245
62Molar tooth sign on MRI (HP:0002419)2.34729359
63Abnormality of midbrain morphology (HP:0002418)2.34729359
64Abnormality of the common coagulation pathway (HP:0010990)2.33329550
65Nausea (HP:0002018)2.31517290
66Spastic tetraparesis (HP:0001285)2.30685395
67Upper limb muscle weakness (HP:0003484)2.23103464
68Supernumerary spleens (HP:0009799)2.20576118
69Increased density of long bones (HP:0006392)2.15608325
70Tubular atrophy (HP:0000092)2.14978275
71Thrombocytosis (HP:0001894)2.14320820
72Encephalitis (HP:0002383)2.13101889
73Abnormality of iron homeostasis (HP:0011031)2.11884984
74Renal Fanconi syndrome (HP:0001994)2.10285700
75Xanthomatosis (HP:0000991)2.10183641
76Hypertriglyceridemia (HP:0002155)2.09778693
77Chronic obstructive pulmonary disease (HP:0006510)2.07576046
78Obstructive lung disease (HP:0006536)2.07576046
79Postaxial foot polydactyly (HP:0001830)2.05840013
80Abnormal biliary tract physiology (HP:0012439)2.05775572
81Bile duct proliferation (HP:0001408)2.05775572
82Panhypogammaglobulinemia (HP:0003139)2.04895094
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04893432
84Hypophosphatemic rickets (HP:0004912)2.03056171
85Abnormal auditory evoked potentials (HP:0006958)2.02601711
86Impaired proprioception (HP:0010831)2.02439897
87Abnormality of transition element cation homeostasis (HP:0011030)2.01091930
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6133738
89Dynein arm defect of respiratory motile cilia (HP:0012255)11.9791362
90Absent/shortened dynein arms (HP:0200106)11.9791362
91Prolonged bleeding time (HP:0003010)10.5662083
92Hyperthyroidism (HP:0000836)1.99074451
93Heterotopia (HP:0002282)1.98988117
94Tubulointerstitial abnormality (HP:0001969)1.97198629
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96399495
96Type 2 muscle fiber atrophy (HP:0003554)1.95085301
97Tinnitus (HP:0000360)1.94185632
98Severe visual impairment (HP:0001141)1.93917376
99Muscle fiber atrophy (HP:0100295)1.93640614
100Increased serum ferritin (HP:0003281)1.91930582
101Dysautonomia (HP:0002459)1.89418801
102Congenital hepatic fibrosis (HP:0002612)1.87431755
103Inflammation of the large intestine (HP:0002037)1.84135788
104Myocardial infarction (HP:0001658)1.82987183
105Fibular hypoplasia (HP:0003038)1.81263601
106Cerebral palsy (HP:0100021)1.80749123
107Autoimmune hemolytic anemia (HP:0001890)1.80584914
108Tongue fasciculations (HP:0001308)1.80329040
109Abnormality of the renal cortex (HP:0011035)1.79434259
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79070533
111Absent epiphyses (HP:0010577)1.79070533
112Basal ganglia calcification (HP:0002135)1.78815837
113IgM deficiency (HP:0002850)1.77946964
114IgA deficiency (HP:0002720)1.75675658
115Portal hypertension (HP:0001409)1.72855637
116Polycythemia (HP:0001901)1.72458052
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.71081075
118Pancreatic fibrosis (HP:0100732)1.70812059
119IgG deficiency (HP:0004315)1.70748197
120Resting tremor (HP:0002322)1.70027600
121Renal dysplasia (HP:0000110)1.67754203
122Increased IgE level (HP:0003212)1.67232586
123Exertional dyspnea (HP:0002875)1.65702203
124Short ribs (HP:0000773)1.64540339
125Abnormality of permanent molar morphology (HP:0011071)1.64539288
126Abnormality of the dental root (HP:0006486)1.64539288
127Taurodontia (HP:0000679)1.64539288
128Abnormality of ocular smooth pursuit (HP:0000617)1.64220598
129Muscle fibrillation (HP:0010546)1.63619610
130Abolished electroretinogram (ERG) (HP:0000550)1.62331585
131Gastrointestinal inflammation (HP:0004386)1.61420102
132Amaurosis fugax (HP:0100576)1.61347519
133Abnormality of male internal genitalia (HP:0000022)1.60214085
134Facial cleft (HP:0002006)1.59964447
135Absent frontal sinuses (HP:0002688)1.59882841
136Oligodactyly (hands) (HP:0001180)1.59372856
137Thyroid-stimulating hormone excess (HP:0002925)1.58362239
138Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57710013
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.56745739
140Chronic sinusitis (HP:0011109)1.56528255
141Abnormality of the hepatic vasculature (HP:0006707)1.55207829
142Aplastic anemia (HP:0001915)1.54471989
143Polyphagia (HP:0002591)1.54461499
144Hypergammaglobulinemia (HP:0010702)1.54274953
145Chest pain (HP:0100749)1.54126860
146Arterial thrombosis (HP:0004420)1.53636668
147Abnormality of the dental pulp (HP:0006479)1.52877302
148Prostate neoplasm (HP:0100787)1.52368440
14911 pairs of ribs (HP:0000878)1.49647110
150Oculomotor apraxia (HP:0000657)1.49534923
151Vertigo (HP:0002321)1.49416009
152Broad distal phalanx of finger (HP:0009836)1.49051268
153Tubulointerstitial fibrosis (HP:0005576)1.48140904
154Ventricular fibrillation (HP:0001663)1.47904116
155Abnormality of molar (HP:0011077)1.47673689
156Abnormality of molar morphology (HP:0011070)1.47673689
157Stage 5 chronic kidney disease (HP:0003774)1.47431742
158Median cleft lip (HP:0000161)1.47107319
159Conjunctival telangiectasia (HP:0000524)1.45204176
160Cystic liver disease (HP:0006706)1.44890748
161Cholecystitis (HP:0001082)1.43357784
162Abnormal gallbladder physiology (HP:0012438)1.43357784
163Gait imbalance (HP:0002141)1.41853438
164Postaxial hand polydactyly (HP:0001162)1.41515718
165Congenital primary aphakia (HP:0007707)1.41080623
166Tetraplegia (HP:0002445)1.40077985
167Personality changes (HP:0000751)1.39179609
168Short thorax (HP:0010306)1.35228662
169Sloping forehead (HP:0000340)1.35015955
170Abnormal drinking behavior (HP:0030082)1.34292503
171Polydipsia (HP:0001959)1.34292503
172Easy fatigability (HP:0003388)1.34225295
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.33848296
174Bundle branch block (HP:0011710)1.31552467
175Selective tooth agenesis (HP:0001592)1.30795428
176Short femoral neck (HP:0100864)1.30211087
177Nephrogenic diabetes insipidus (HP:0009806)1.29547820
178Abnormality of renal excretion (HP:0011036)1.26922125
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.26803851
180Nephropathy (HP:0000112)1.26549644
181Poor coordination (HP:0002370)1.25957464
182Abnormality of the ileum (HP:0001549)1.24420583
183Microglossia (HP:0000171)1.23374172
184Aplasia/Hypoplasia of the fibula (HP:0006492)1.22661434
185Ectopic kidney (HP:0000086)1.21537256
186True hermaphroditism (HP:0010459)1.20690883
187Hypoplasia of the radius (HP:0002984)1.20630515
188Pancreatic cysts (HP:0001737)1.20114430
189J-shaped sella turcica (HP:0002680)1.20108341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.27324446
2PDK48.27324446
3PDK25.07952930
4MST44.54101217
5TESK14.08854048
6ICK3.61410277
7BMX3.55161499
8PRKD33.46119719
9NEK23.19716839
10MYLK2.81102032
11TAOK32.34937029
12FES2.32840919
13NUAK12.28083191
14KDR2.25673981
15CSF1R2.19114885
16PNCK2.16283757
17PIK3CG2.09895266
18VRK22.01824651
19SYK2.00660239
20PTK2B1.91506004
21WNK41.78202185
22MAPKAPK31.71458181
23ITK1.68070019
24WEE11.67280942
25ILK1.64918434
26STK381.63675870
27GRK51.56306463
28DYRK31.55113026
29PIM21.47154390
30STK391.43302269
31CCNB11.42459440
32BMPR21.41333317
33ARAF1.40800604
34STK241.35830437
35BLK1.35181855
36HCK1.32125854
37TIE11.30464338
38TNK21.30127561
39DAPK21.29431989
40FGR1.27198040
41DYRK1B1.25682449
42STK31.23832119
43MUSK1.22191084
44TTK1.21078944
45IKBKB1.20848642
46DAPK11.16739722
47BRSK21.12746015
48MAP3K111.12682951
49ADRBK21.11254534
50DAPK31.11168522
51GRK61.08193854
52TLK11.07931816
53MAPK151.05244733
54LYN1.02680699
55ZAK1.01002789
56CDC70.96786730
57PLK20.95288408
58NTRK20.94101630
59TXK0.93703337
60CHEK20.93612088
61FER0.92383144
62PDK10.87440147
63MATK0.85272687
64TYRO30.83340706
65WNK10.83217778
66TAOK20.82882509
67PLK10.81769770
68BMPR1B0.81715875
69ATR0.79028676
70BCKDK0.78713786
71CHEK10.77975666
72BUB10.77571436
73GRK10.76740187
74PASK0.76400446
75PLK40.74034595
76PRKCQ0.73355958
77FLT30.72888331
78CDK120.70660304
79KIT0.69006341
80TNIK0.66693402
81EEF2K0.66513597
82PINK10.65586820
83DDR20.63898270
84TRPM70.63224580
85ACVR1B0.62383804
86BRSK10.61795017
87MAP3K50.61225487
88CSK0.60420934
89INSRR0.60073908
90CDK70.57892616
91ADRBK10.57556551
92PKN10.55915790
93MAP3K60.54412183
94RIPK40.53950339
95CDK30.53821650
96PRKAA10.53296963
97SCYL20.52899728
98EIF2AK10.52431484
99ATM0.52223955
100MAP2K60.51190107
101JAK30.49053511
102MAP2K30.45774069
103LCK0.41573756
104DYRK20.40210360
105TESK20.39497871
106CAMK1G0.39282173
107MAP4K10.38549600
108PAK10.38051049
109MTOR0.37416093
110SRPK10.37194877
111PRKG10.35136073
112MAPK120.34272012
113MAP3K100.34111425
114TAOK10.33418933
115IGF1R0.31361633
116MAPKAPK50.31340756
117ROCK10.30955977
118PRKD10.30955415
119RET0.30646515
120IRAK10.30222129
121PRKACG0.30192863
122MARK30.28910550
123MAPK130.28639172
124STK38L0.28490862
125CDK20.28403480
126CAMKK10.26795288
127MAPK110.26751949
128PLK30.26318373
129STK160.25452730
130RPS6KA50.25216422
131CDK40.24887911
132PRKCB0.24599476
133STK100.24587170
134PDPK10.24574902
135MAPK40.23911983
136ERBB20.23655359
137MARK10.23534268
138LATS20.22751841
139SIK20.21904384
140LMTK20.21863767
141PRKCG0.21413388
142PRKCA0.20667393
143PIM10.18946816
144CDK10.18240115
145AURKB0.17721369
146BRAF0.15170463
147BTK0.15147461
148TGFBR10.14779174
149PAK20.14339158
150AURKA0.13389169
151GSK3B0.12612093
152TYK20.12525829
153WNK30.11626774
154ZAP700.11497416
155YES10.11208827
156MAP3K90.11200068
157CDK90.09752073
158MAPK80.09314388
159TBK10.09307630
160RPS6KB10.09280749
161MARK20.09024668
162CSNK2A10.08907576
163CDK11A0.08812589
164NEK60.08656165
165CAMK10.08525800
166VRK10.07011384
167STK110.06843560
168TEC0.06731066
169CSNK2A20.06473889
170RPS6KA40.04936087

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.54865330
2Platelet activation_Homo sapiens_hsa046115.18947724
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.70511963
4Basal transcription factors_Homo sapiens_hsa030223.42999575
5SNARE interactions in vesicular transport_Homo sapiens_hsa041303.41669430
6Fatty acid biosynthesis_Homo sapiens_hsa000613.01894708
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.98229523
8Hematopoietic cell lineage_Homo sapiens_hsa046402.91696549
9Pyruvate metabolism_Homo sapiens_hsa006202.80793964
10Fanconi anemia pathway_Homo sapiens_hsa034602.78647556
11Pentose phosphate pathway_Homo sapiens_hsa000302.69107890
12Dorso-ventral axis formation_Homo sapiens_hsa043202.50260913
13RNA transport_Homo sapiens_hsa030132.48357087
14Arachidonic acid metabolism_Homo sapiens_hsa005902.42734787
15Selenocompound metabolism_Homo sapiens_hsa004502.19316340
16Oocyte meiosis_Homo sapiens_hsa041142.15270616
17Glucagon signaling pathway_Homo sapiens_hsa049222.14645729
18Propanoate metabolism_Homo sapiens_hsa006402.01356234
19ECM-receptor interaction_Homo sapiens_hsa045121.98111220
20Olfactory transduction_Homo sapiens_hsa047401.90767377
21mRNA surveillance pathway_Homo sapiens_hsa030151.90316129
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84662685
23Glycerolipid metabolism_Homo sapiens_hsa005611.76826279
24Linoleic acid metabolism_Homo sapiens_hsa005911.71788905
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.70680846
26Asthma_Homo sapiens_hsa053101.69941483
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66671834
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65347109
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.63567864
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62940351
31Fructose and mannose metabolism_Homo sapiens_hsa000511.59018568
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.57866147
33Nitrogen metabolism_Homo sapiens_hsa009101.57575622
34Pyrimidine metabolism_Homo sapiens_hsa002401.57304225
35Sulfur metabolism_Homo sapiens_hsa009201.56036252
36Fatty acid elongation_Homo sapiens_hsa000621.51933759
37Antigen processing and presentation_Homo sapiens_hsa046121.48075257
38Purine metabolism_Homo sapiens_hsa002301.47798495
39Homologous recombination_Homo sapiens_hsa034401.46317213
40RNA polymerase_Homo sapiens_hsa030201.44646590
41Allograft rejection_Homo sapiens_hsa053301.40101495
42Autoimmune thyroid disease_Homo sapiens_hsa053201.39929217
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37169619
44Cell cycle_Homo sapiens_hsa041101.33770584
45Graft-versus-host disease_Homo sapiens_hsa053321.32069690
46Collecting duct acid secretion_Homo sapiens_hsa049661.29527604
47Gap junction_Homo sapiens_hsa045401.26186951
48PPAR signaling pathway_Homo sapiens_hsa033201.25754419
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25679085
50Chemokine signaling pathway_Homo sapiens_hsa040621.24806118
51Huntingtons disease_Homo sapiens_hsa050161.22549798
52Alcoholism_Homo sapiens_hsa050341.19271337
53Spliceosome_Homo sapiens_hsa030401.18502947
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.16865753
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12086072
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11937226
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11302847
58Serotonergic synapse_Homo sapiens_hsa047261.09746460
59ABC transporters_Homo sapiens_hsa020101.09533690
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05314777
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02397264
62DNA replication_Homo sapiens_hsa030301.01962363
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98847455
64Biosynthesis of amino acids_Homo sapiens_hsa012300.98273322
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95093765
66Amphetamine addiction_Homo sapiens_hsa050310.95079272
67Shigellosis_Homo sapiens_hsa051310.94898393
68Carbon metabolism_Homo sapiens_hsa012000.94510826
69Fat digestion and absorption_Homo sapiens_hsa049750.93272113
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91746019
71RNA degradation_Homo sapiens_hsa030180.91309512
72p53 signaling pathway_Homo sapiens_hsa041150.89954659
73Staphylococcus aureus infection_Homo sapiens_hsa051500.88161094
74Phagosome_Homo sapiens_hsa041450.84930102
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84755738
76Epstein-Barr virus infection_Homo sapiens_hsa051690.84572122
77Phototransduction_Homo sapiens_hsa047440.83348147
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82911008
79One carbon pool by folate_Homo sapiens_hsa006700.80813973
80Malaria_Homo sapiens_hsa051440.80245688
81Type I diabetes mellitus_Homo sapiens_hsa049400.80226841
82Nucleotide excision repair_Homo sapiens_hsa034200.79306591
83Pancreatic secretion_Homo sapiens_hsa049720.78921925
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78591887
85Rheumatoid arthritis_Homo sapiens_hsa053230.77876660
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76893475
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76169198
88B cell receptor signaling pathway_Homo sapiens_hsa046620.75685241
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73046739
90Fatty acid metabolism_Homo sapiens_hsa012120.72100618
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70828069
92Chemical carcinogenesis_Homo sapiens_hsa052040.70576345
93Viral myocarditis_Homo sapiens_hsa054160.69790128
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67515470
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.67085806
96Base excision repair_Homo sapiens_hsa034100.65947728
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65471889
98Fatty acid degradation_Homo sapiens_hsa000710.63542631
99Vitamin digestion and absorption_Homo sapiens_hsa049770.63274026
100Starch and sucrose metabolism_Homo sapiens_hsa005000.60839917
101Mineral absorption_Homo sapiens_hsa049780.60618964
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60552975
103Parkinsons disease_Homo sapiens_hsa050120.59612246
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.59536220
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58819080
106Proteasome_Homo sapiens_hsa030500.54264085
107Calcium signaling pathway_Homo sapiens_hsa040200.51867960
108Long-term potentiation_Homo sapiens_hsa047200.51036132
109Systemic lupus erythematosus_Homo sapiens_hsa053220.50825794
110Apoptosis_Homo sapiens_hsa042100.50772382
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.50712200
112Peroxisome_Homo sapiens_hsa041460.49347992
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.47827058
114Glutathione metabolism_Homo sapiens_hsa004800.46518740
115Viral carcinogenesis_Homo sapiens_hsa052030.45624526
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45301022
117Estrogen signaling pathway_Homo sapiens_hsa049150.44572458
118Galactose metabolism_Homo sapiens_hsa000520.43071242
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42078458
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41875214
121Herpes simplex infection_Homo sapiens_hsa051680.39934347
122Measles_Homo sapiens_hsa051620.39852319
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39826472
124Morphine addiction_Homo sapiens_hsa050320.39290941
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39164402
126Circadian entrainment_Homo sapiens_hsa047130.38605017
127Sulfur relay system_Homo sapiens_hsa041220.38587552
128Influenza A_Homo sapiens_hsa051640.38537312
129Renin secretion_Homo sapiens_hsa049240.38121206
130Hedgehog signaling pathway_Homo sapiens_hsa043400.38039987
131Cardiac muscle contraction_Homo sapiens_hsa042600.36107600
132Primary immunodeficiency_Homo sapiens_hsa053400.35229655
133Endocytosis_Homo sapiens_hsa041440.34001647
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33941421
135Mismatch repair_Homo sapiens_hsa034300.33507681
136AMPK signaling pathway_Homo sapiens_hsa041520.33477385
137Ether lipid metabolism_Homo sapiens_hsa005650.33204260
138Regulation of autophagy_Homo sapiens_hsa041400.32817898
139T cell receptor signaling pathway_Homo sapiens_hsa046600.31816698
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31589965
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31225343
142Metabolic pathways_Homo sapiens_hsa011000.30679430
143Rap1 signaling pathway_Homo sapiens_hsa040150.30583680
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30537955
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30354582
146Focal adhesion_Homo sapiens_hsa045100.30338927
147Legionellosis_Homo sapiens_hsa051340.30134405
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30036096
149Bile secretion_Homo sapiens_hsa049760.28999575
150Retinol metabolism_Homo sapiens_hsa008300.28593624
151Taste transduction_Homo sapiens_hsa047420.27885121
152Circadian rhythm_Homo sapiens_hsa047100.27212479
153Primary bile acid biosynthesis_Homo sapiens_hsa001200.27190786
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27071199
155Renin-angiotensin system_Homo sapiens_hsa046140.26981301
156Inositol phosphate metabolism_Homo sapiens_hsa005620.26898277
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26513780
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25926877
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25701237
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.22661029
161VEGF signaling pathway_Homo sapiens_hsa043700.20998517
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20899136
163Intestinal immune network for IgA production_Homo sapiens_hsa046720.20484841
164Cyanoamino acid metabolism_Homo sapiens_hsa004600.18668346

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