CAPN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.00048689
2axon ensheathment in central nervous system (GO:0032291)7.00048689
3ribosomal small subunit biogenesis (GO:0042274)5.93461518
4viral transcription (GO:0019083)5.59256340
5translational termination (GO:0006415)5.29263812
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.15720180
7ATP synthesis coupled proton transport (GO:0015986)4.75026472
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75026472
9protein targeting to ER (GO:0045047)4.71005055
10cotranslational protein targeting to membrane (GO:0006613)4.67250904
11protein complex biogenesis (GO:0070271)4.65276768
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.58936617
13behavioral response to nicotine (GO:0035095)4.56468774
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54319894
15water-soluble vitamin biosynthetic process (GO:0042364)4.39027939
16protein localization to endoplasmic reticulum (GO:0070972)4.38965525
17limb bud formation (GO:0060174)4.31501488
18mitochondrial respiratory chain complex assembly (GO:0033108)4.30103437
19NADH dehydrogenase complex assembly (GO:0010257)4.29405036
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29405036
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.29405036
22endothelium development (GO:0003158)4.24456763
23short-term memory (GO:0007614)4.23629698
24viral life cycle (GO:0019058)4.15961201
25protein neddylation (GO:0045116)4.02961812
26cellular protein complex disassembly (GO:0043624)4.02212921
27keratinocyte development (GO:0003334)3.99483715
28fatty acid elongation (GO:0030497)3.95882769
29DNA deamination (GO:0045006)3.95223790
30long-chain fatty acid biosynthetic process (GO:0042759)3.94540742
31ribosomal large subunit biogenesis (GO:0042273)3.90591379
32platelet dense granule organization (GO:0060155)3.83025799
33lateral sprouting from an epithelium (GO:0060601)3.80643546
34sphingoid metabolic process (GO:0046519)3.78854974
35glucosamine-containing compound catabolic process (GO:1901072)3.76945633
36nephron tubule morphogenesis (GO:0072078)3.73961327
37nephron epithelium morphogenesis (GO:0072088)3.73961327
38translational elongation (GO:0006414)3.72540537
39keratinocyte proliferation (GO:0043616)3.68832167
40hair cycle (GO:0042633)3.67513338
41molting cycle (GO:0042303)3.67513338
42respiratory chain complex IV assembly (GO:0008535)3.59614835
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58155969
44cellular ketone body metabolic process (GO:0046950)3.52009634
45cytochrome complex assembly (GO:0017004)3.48301568
46negative regulation of execution phase of apoptosis (GO:1900118)3.47637261
47presynaptic membrane assembly (GO:0097105)3.44947169
48protein-cofactor linkage (GO:0018065)3.39434908
49myelination (GO:0042552)3.33948073
50chaperone-mediated protein transport (GO:0072321)3.31042574
51ensheathment of neurons (GO:0007272)3.30842768
52axon ensheathment (GO:0008366)3.30842768
53negative regulation of keratinocyte proliferation (GO:0010839)3.21134978
54maturation of SSU-rRNA (GO:0030490)3.21046927
55presynaptic membrane organization (GO:0097090)3.20117866
56detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15668538
57protein complex disassembly (GO:0043241)3.14861808
58photoreceptor cell differentiation (GO:0046530)3.13764475
59eye photoreceptor cell differentiation (GO:0001754)3.13764475
60protein targeting to membrane (GO:0006612)3.13067485
61mannosylation (GO:0097502)3.12772361
62high-density lipoprotein particle remodeling (GO:0034375)3.12385439
63ketone body metabolic process (GO:1902224)3.12284756
64desmosome organization (GO:0002934)3.10777487
65diol metabolic process (GO:0034311)3.10264196
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08789206
67response to pheromone (GO:0019236)3.04230553
68translational initiation (GO:0006413)3.03344738
69tryptophan catabolic process (GO:0006569)3.01558397
70indole-containing compound catabolic process (GO:0042436)3.01558397
71indolalkylamine catabolic process (GO:0046218)3.01558397
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98804648
73macromolecular complex disassembly (GO:0032984)2.93473503
74positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.93252007
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.92023112
76hydrogen ion transmembrane transport (GO:1902600)2.91616450
77aromatic amino acid family catabolic process (GO:0009074)2.89170721
78intracellular protein transmembrane import (GO:0044743)2.85949664
79mitotic nuclear envelope reassembly (GO:0007084)2.83446153
80nuclear envelope reassembly (GO:0031468)2.83446153
81import into cell (GO:0098657)2.83046118
82rRNA modification (GO:0000154)2.81328157
83proton transport (GO:0015992)2.81174649
84drug catabolic process (GO:0042737)2.78504747
85hydrogen transport (GO:0006818)2.76058783
86lymph vessel development (GO:0001945)2.75553333
87otic vesicle formation (GO:0030916)2.75332389
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75234585
89L-phenylalanine catabolic process (GO:0006559)2.75234585
90oligodendrocyte differentiation (GO:0048709)2.74531222
91indolalkylamine metabolic process (GO:0006586)2.73507666
92neuron remodeling (GO:0016322)2.73110972
93regulation of mitochondrial translation (GO:0070129)2.72968765
94ATP biosynthetic process (GO:0006754)2.72597179
95pattern specification involved in kidney development (GO:0061004)2.72342299
96renal tubule morphogenesis (GO:0061333)2.71889548
97heme transport (GO:0015886)2.70957972
98cardiac epithelial to mesenchymal transition (GO:0060317)2.69920494
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69413530
100negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.67050135
101reverse cholesterol transport (GO:0043691)2.66725632
102negative regulation of myoblast differentiation (GO:0045662)2.66297148
103rRNA methylation (GO:0031167)2.66136457
104preassembly of GPI anchor in ER membrane (GO:0016254)2.64811739
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63471203
106dopamine transport (GO:0015872)2.63074416
107mesonephros development (GO:0001823)2.62097390
108adaptation of signaling pathway (GO:0023058)2.61668902
109cerebral cortex radially oriented cell migration (GO:0021799)2.61569139
110regulation of triglyceride catabolic process (GO:0010896)2.61415542
111negative regulation of protein localization to cell surface (GO:2000009)2.60368541
112DNA ligation (GO:0006266)2.60244228
113GPI anchor biosynthetic process (GO:0006506)2.60229024
114developmental pigmentation (GO:0048066)2.60072038
115fucose catabolic process (GO:0019317)2.57614945
116L-fucose metabolic process (GO:0042354)2.57614945
117L-fucose catabolic process (GO:0042355)2.57614945
118purine nucleoside triphosphate biosynthetic process (GO:0009145)2.57061287
119regulation of somitogenesis (GO:0014807)2.56636359
120axoneme assembly (GO:0035082)2.54022132
121purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.53444980
122cranial nerve development (GO:0021545)2.53286664
123regulation of cell proliferation involved in kidney development (GO:1901722)2.51214508
124positive regulation of protein kinase C signaling (GO:0090037)2.51131360
125phosphatidylserine acyl-chain remodeling (GO:0036150)2.50330982
126positive regulation of cellular amine metabolic process (GO:0033240)2.49798315
127pseudouridine synthesis (GO:0001522)2.49106302
128cranial nerve morphogenesis (GO:0021602)2.47332278
129vitamin biosynthetic process (GO:0009110)2.47166997
130aldehyde catabolic process (GO:0046185)2.46384474
131cytidine metabolic process (GO:0046087)2.46369631
132cytidine catabolic process (GO:0006216)2.46369631
133cytidine deamination (GO:0009972)2.46369631
134tryptophan metabolic process (GO:0006568)2.45982143
135regulation of cilium movement (GO:0003352)2.45753145
136somite development (GO:0061053)2.45445547
137proteasome assembly (GO:0043248)2.44989018
138regulation of glucokinase activity (GO:0033131)2.44632861
139regulation of hexokinase activity (GO:1903299)2.44632861
140sphingosine metabolic process (GO:0006670)2.44248175
141regulation of keratinocyte proliferation (GO:0010837)2.44226091
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.43570382
143arginine metabolic process (GO:0006525)2.43057849
144serine family amino acid catabolic process (GO:0009071)2.42459639
145cellular biogenic amine catabolic process (GO:0042402)2.42263364
146amine catabolic process (GO:0009310)2.42263364
147S-adenosylmethionine metabolic process (GO:0046500)2.41650055
148kidney morphogenesis (GO:0060993)2.41195431
149regulation of protein kinase C signaling (GO:0090036)2.40877011
150epithelial cilium movement (GO:0003351)2.40823577
151regulation of cytokine production involved in inflammatory response (GO:1900015)2.40091323
152anterograde synaptic vesicle transport (GO:0048490)2.39904604
153iron coordination entity transport (GO:1901678)2.39784145
154peptidyl-histidine modification (GO:0018202)2.39677011
155negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.39423781
156regulation of timing of cell differentiation (GO:0048505)2.38786142
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37643751
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37643751
159calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.36926453
160keratinization (GO:0031424)2.36698897
161ribosomal small subunit assembly (GO:0000028)2.36166743
162transepithelial transport (GO:0070633)2.35944976
163enteric nervous system development (GO:0048484)2.35554903
164respiratory electron transport chain (GO:0022904)2.35311369
165exogenous drug catabolic process (GO:0042738)2.35236237
166GPI anchor metabolic process (GO:0006505)2.33723804
167neuron fate determination (GO:0048664)2.33014788
168neural crest cell development (GO:0014032)2.30997653
169transcription elongation from RNA polymerase III promoter (GO:0006385)2.30816587
170termination of RNA polymerase III transcription (GO:0006386)2.30816587
171mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.30196254
172amino acid import (GO:0043090)2.29889809
173regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.29785840
174positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.28834830
175GTP biosynthetic process (GO:0006183)2.28225489
176positive regulation of meiotic cell cycle (GO:0051446)2.26749681
177electron transport chain (GO:0022900)2.26470326
178regulation of development, heterochronic (GO:0040034)2.25586361
179radial glial cell differentiation (GO:0060019)2.25576123
180eyelid development in camera-type eye (GO:0061029)2.25269601
181organ growth (GO:0035265)2.25168133
182regulation of pigment cell differentiation (GO:0050932)2.25023508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.12003834
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.45588812
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.65156132
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.30515602
5ZNF274_21170338_ChIP-Seq_K562_Hela3.28308639
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.88765427
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79557116
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.76074691
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69038311
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.60630442
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.54461572
12VDR_22108803_ChIP-Seq_LS180_Human2.53682700
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52116351
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50236980
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49906153
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.45418378
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39810605
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.27309264
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21289271
20TAF15_26573619_Chip-Seq_HEK293_Human2.20681610
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.19694767
22GBX2_23144817_ChIP-Seq_PC3_Human2.18969585
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17780384
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16105200
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08858697
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08438242
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03643908
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02913645
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00981685
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00921562
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98781189
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91383575
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91383575
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91383575
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90383078
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90383078
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86468107
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84080428
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83294860
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.80089909
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74293904
42MYC_18940864_ChIP-ChIP_HL60_Human1.69078293
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68469111
44AR_21572438_ChIP-Seq_LNCaP_Human1.68238842
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66630602
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66580266
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64497745
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62587033
49BCAT_22108803_ChIP-Seq_LS180_Human1.61518265
50RNF2_27304074_Chip-Seq_NSC_Mouse1.61092973
51EZH2_22144423_ChIP-Seq_EOC_Human1.59016536
52* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58454317
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57109028
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.56761915
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56624437
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55951262
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54911300
58ELK1_19687146_ChIP-ChIP_HELA_Human1.54636066
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54017923
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.54017923
61* TP53_22573176_ChIP-Seq_HFKS_Human1.53628543
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52250252
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.52108622
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51657400
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.49582349
66ER_23166858_ChIP-Seq_MCF-7_Human1.48652056
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.48565233
68* NANOG_19829295_ChIP-Seq_ESCs_Human1.48505358
69* SOX2_19829295_ChIP-Seq_ESCs_Human1.48505358
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.48251058
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45874770
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.45859243
73TP53_18474530_ChIP-ChIP_U2OS_Human1.45055627
74VDR_23849224_ChIP-Seq_CD4+_Human1.44983803
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44838719
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44564362
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43853767
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.42716713
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.40246210
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39508337
81IGF1R_20145208_ChIP-Seq_DFB_Human1.39261393
82* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37106021
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36336476
84P300_19829295_ChIP-Seq_ESCs_Human1.35783097
85CBP_20019798_ChIP-Seq_JUKART_Human1.35535285
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35535285
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35139764
88FUS_26573619_Chip-Seq_HEK293_Human1.34155491
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32607227
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30645787
91AR_20517297_ChIP-Seq_VCAP_Human1.29004702
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.28184435
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27520158
94NCOR_22424771_ChIP-Seq_293T_Human1.27428829
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27056698
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26863349
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26620209
98* GATA3_21878914_ChIP-Seq_MCF-7_Human1.26077326
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24982093
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23376045
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23376045
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22346809
103TCF4_22108803_ChIP-Seq_LS180_Human1.21226452
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.20612436
105MYC_19829295_ChIP-Seq_ESCs_Human1.19886910
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.19708359
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19109199
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18662141
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.18660670
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17584761
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17484708
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17484708
113P300_18555785_Chip-Seq_ESCs_Mouse1.17082287
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17021295
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.16997963
116P53_22387025_ChIP-Seq_ESCs_Mouse1.16082984
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15232480
118FOXH1_21741376_ChIP-Seq_EPCs_Human1.15139831
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.14587560
120AR_25329375_ChIP-Seq_VCAP_Human1.14469539
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.13952798
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12886558
123CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12729891
124P53_21459846_ChIP-Seq_SAOS-2_Human1.12474916
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12136913
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11546050
127ERA_21632823_ChIP-Seq_H3396_Human1.11009481
128HTT_18923047_ChIP-ChIP_STHdh_Human1.10953829
129NANOG_20526341_ChIP-Seq_ESCs_Human1.10817478
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09528831
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09033100
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08427262
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.08271579
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07964209
135TAF2_19829295_ChIP-Seq_ESCs_Human1.07933002
136ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06198762
137RING1B_27294783_Chip-Seq_NPCs_Mouse1.05490918
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05448777
139HOXB7_26014856_ChIP-Seq_BT474_Human1.05286132
140CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04307289
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03855809
142NMYC_18555785_Chip-Seq_ESCs_Mouse1.03716711
143PHF8_20622853_ChIP-Seq_HELA_Human1.03497384
144CDX2_22108803_ChIP-Seq_LS180_Human1.01915195
145FOXP3_21729870_ChIP-Seq_TREG_Human1.00823690
146TP53_16413492_ChIP-PET_HCT116_Human1.00680984
147KLF4_18555785_Chip-Seq_ESCs_Mouse1.00646230
148STAT3_18555785_Chip-Seq_ESCs_Mouse1.00635565
149EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00502579
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00358492
151ETV1_20927104_ChIP-Seq_GIST48_Human1.00218082
152SOX2_18555785_Chip-Seq_ESCs_Mouse1.00138296
153REST_21632747_ChIP-Seq_MESCs_Mouse1.00117707
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99667814
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.99291064
156RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99152457
157OCT4_18555785_Chip-Seq_ESCs_Mouse0.98395695
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97733219
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97522465
160RBPJ_21746931_ChIP-Seq_IB4_Human0.97464102
161* SOX2_20726797_ChIP-Seq_SW620_Human0.96627837
162ZFX_18555785_Chip-Seq_ESCs_Mouse0.96543105
163FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96096649
164RUNX2_22187159_ChIP-Seq_PCA_Human0.95967610
165IRF1_19129219_ChIP-ChIP_H3396_Human0.95644210
166CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94172441
167FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93108859
168EWS_26573619_Chip-Seq_HEK293_Human0.92559558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.65428127
2MP0003136_yellow_coat_color4.37346871
3MP0004381_abnormal_hair_follicle3.90735761
4MP0003941_abnormal_skin_development3.53008173
5MP0005409_darkened_coat_color3.51259013
6MP0003195_calcinosis3.20144947
7MP0002796_impaired_skin_barrier2.89252563
8MP0003724_increased_susceptibility_to2.66176771
9MP0001188_hyperpigmentation2.64013506
10MP0001346_abnormal_lacrimal_gland2.56074430
11MP0008875_abnormal_xenobiotic_pharmacok2.53269514
12MP0003880_abnormal_central_pattern2.53093691
13MP0000566_synostosis2.47183863
14MP0002138_abnormal_hepatobiliary_system2.31194775
15MP0002098_abnormal_vibrissa_morphology2.26039810
16MP0002102_abnormal_ear_morphology2.25579789
17MP0004043_abnormal_pH_regulation2.13650453
18MP0000762_abnormal_tongue_morphology2.11303640
19MP0000920_abnormal_myelination2.06473170
20MP0002876_abnormal_thyroid_physiology2.03627934
21MP0002139_abnormal_hepatobiliary_system2.01807870
22MP0004885_abnormal_endolymph1.99868337
23MP0004742_abnormal_vestibular_system1.97287839
24MP0009250_abnormal_appendicular_skeleto1.94292706
25MP0002837_dystrophic_cardiac_calcinosis1.92242678
26MP0003787_abnormal_imprinting1.89918255
27MP0008877_abnormal_DNA_methylation1.89406309
28MP0000647_abnormal_sebaceous_gland1.89082793
29MP0000383_abnormal_hair_follicle1.85718242
30MP0002009_preneoplasia1.83812259
31MP0003938_abnormal_ear_development1.81757253
32MP0002277_abnormal_respiratory_mucosa1.76308286
33MP0003950_abnormal_plasma_membrane1.73934880
34MP0003878_abnormal_ear_physiology1.73671132
35MP0005377_hearing/vestibular/ear_phenot1.73671132
36MP0005085_abnormal_gallbladder_physiolo1.73193922
37MP0005171_absent_coat_pigmentation1.72932774
38MP0005501_abnormal_skin_physiology1.65495341
39MP0001764_abnormal_homeostasis1.64736772
40MP0004133_heterotaxia1.64511695
41MP0002928_abnormal_bile_duct1.63628380
42MP0005646_abnormal_pituitary_gland1.63112765
43MP0002736_abnormal_nociception_after1.61495159
44MP0008872_abnormal_physiological_respon1.59437821
45MP0005332_abnormal_amino_acid1.59274444
46MP0004019_abnormal_vitamin_homeostasis1.54990833
47MP0010678_abnormal_skin_adnexa1.54513263
48MP0005360_urolithiasis1.53462262
49MP0000579_abnormal_nail_morphology1.51669167
50MP0000467_abnormal_esophagus_morphology1.51229590
51MP0001542_abnormal_bone_strength1.50111819
52MP0005365_abnormal_bile_salt1.49823027
53MP0000049_abnormal_middle_ear1.47757824
54MP0003385_abnormal_body_wall1.37617635
55MP0003315_abnormal_perineum_morphology1.36889065
56MP0002177_abnormal_outer_ear1.36471315
57MP0010771_integument_phenotype1.34236285
58MP0002234_abnormal_pharynx_morphology1.33682317
59MP0001879_abnormal_lymphatic_vessel1.33329112
60MP0003937_abnormal_limbs/digits/tail_de1.31998983
61MP0002249_abnormal_larynx_morphology1.31984061
62MP0002638_abnormal_pupillary_reflex1.31196777
63MP0009745_abnormal_behavioral_response1.30323693
64MP0000377_abnormal_hair_follicle1.29331645
65MP0005451_abnormal_body_composition1.29075014
66MP0003453_abnormal_keratinocyte_physiol1.28649986
67MP0004147_increased_porphyrin_level1.27722780
68MP0010329_abnormal_lipoprotein_level1.26703041
69MP0001984_abnormal_olfaction1.24520155
70MP0001216_abnormal_epidermal_layer1.22836517
71MP0002060_abnormal_skin_morphology1.22038753
72MP0005253_abnormal_eye_physiology1.20015807
73MP0000613_abnormal_salivary_gland1.19645420
74MP0005389_reproductive_system_phenotype1.19264298
75MP0003828_pulmonary_edema1.18521276
76MP0003755_abnormal_palate_morphology1.17137859
77MP0002160_abnormal_reproductive_system1.15327577
78MP0001666_abnormal_nutrient_absorption1.13987800
79MP0003252_abnormal_bile_duct1.13571544
80MP0000372_irregular_coat_pigmentation1.13201760
81MP0003011_delayed_dark_adaptation1.13164326
82MP0005379_endocrine/exocrine_gland_phen1.12146128
83MP0003303_peritoneal_inflammation1.12028378
84MP0003283_abnormal_digestive_organ1.12006777
85MP0004272_abnormal_basement_membrane1.11714240
86MP0000778_abnormal_nervous_system1.10573043
87MP0000026_abnormal_inner_ear1.09262552
88MP0009046_muscle_twitch1.06771105
89MP0001340_abnormal_eyelid_morphology1.06713494
90MP0002132_abnormal_respiratory_system1.05908560
91MP0002909_abnormal_adrenal_gland1.05807562
92MP0001529_abnormal_vocalization1.05668727
93MP0005645_abnormal_hypothalamus_physiol1.05187030
94MP0001919_abnormal_reproductive_system1.05103343
95MP0001486_abnormal_startle_reflex1.03999757
96MP0001905_abnormal_dopamine_level1.03915237
97MP0003186_abnormal_redox_activity1.03537059
98MP0003718_maternal_effect1.03528176
99MP0001324_abnormal_eye_pigmentation1.03513585
100MP0002163_abnormal_gland_morphology1.03299052
101MP0005423_abnormal_somatic_nervous1.02502231
102MP0001986_abnormal_taste_sensitivity1.02499954
103MP0000427_abnormal_hair_cycle1.01394995
104MP0004142_abnormal_muscle_tone1.00153451
105MP0001293_anophthalmia1.00067082
106MP0006036_abnormal_mitochondrial_physio0.98767443
107MP0010386_abnormal_urinary_bladder0.97347021
108MP0004185_abnormal_adipocyte_glucose0.96690337
109MP0005195_abnormal_posterior_eye0.96233885
110MP0001485_abnormal_pinna_reflex0.95905189
111MP0005508_abnormal_skeleton_morphology0.95860238
112MP0002254_reproductive_system_inflammat0.95606047
113MP0005275_abnormal_skin_tensile0.95246475
114MP0009053_abnormal_anal_canal0.95205949
115MP0003806_abnormal_nucleotide_metabolis0.95118581
116MP0000462_abnormal_digestive_system0.94881619
117MP0002557_abnormal_social/conspecific_i0.93550745
118MP0000569_abnormal_digit_pigmentation0.93073916
119MP0006292_abnormal_olfactory_placode0.92696028
120MP0005623_abnormal_meninges_morphology0.92261920
121MP0002938_white_spotting0.91988541
122MP0004145_abnormal_muscle_electrophysio0.91640682
123MP0002735_abnormal_chemical_nociception0.90058727
124MP0005410_abnormal_fertilization0.89937169
125MP0003122_maternal_imprinting0.89895164
126MP0001756_abnormal_urination0.88911780
127MP0002653_abnormal_ependyma_morphology0.86481156
128MP0008789_abnormal_olfactory_epithelium0.86000883
129MP0003121_genomic_imprinting0.85636405
130MP0005075_abnormal_melanosome_morpholog0.84770426
131MP0001944_abnormal_pancreas_morphology0.84586467
132MP0002295_abnormal_pulmonary_circulatio0.84484995
133MP0000015_abnormal_ear_pigmentation0.84407558
134MP0005174_abnormal_tail_pigmentation0.84332386
135MP0005595_abnormal_vascular_smooth0.81765503
136MP0003638_abnormal_response/metabolism_0.81441987
137MP0005636_abnormal_mineral_homeostasis0.81427484
138MP0001968_abnormal_touch/_nociception0.81352705
139MP0001970_abnormal_pain_threshold0.81058166
140MP0008438_abnormal_cutaneous_collagen0.80916917
141MP0010030_abnormal_orbit_morphology0.80877011
142MP0008058_abnormal_DNA_repair0.80749320
143MP0009384_cardiac_valve_regurgitation0.77667129
144MP0005551_abnormal_eye_electrophysiolog0.77236784
145MP0002064_seizures0.77129915
146MP0006072_abnormal_retinal_apoptosis0.75261629
147MP0000631_abnormal_neuroendocrine_gland0.75238461
148MP0005367_renal/urinary_system_phenotyp0.75205063
149MP0000516_abnormal_urinary_system0.75205063
150MP0005084_abnormal_gallbladder_morpholo0.74192953
151MP0001243_abnormal_dermal_layer0.74096379
152MP0003890_abnormal_embryonic-extraembry0.74052578
153MP0006276_abnormal_autonomic_nervous0.72414489
154MP0001851_eye_inflammation0.70868965
155MP0004270_analgesia0.70859954
156MP0002272_abnormal_nervous_system0.69954342
157MP0000432_abnormal_head_morphology0.68775726
158MP0002282_abnormal_trachea_morphology0.67937010
159MP0002095_abnormal_skin_pigmentation0.65491342
160MP0002116_abnormal_craniofacial_bone0.65405188
161MP0005257_abnormal_intraocular_pressure0.64913235
162MP0002752_abnormal_somatic_nervous0.64748662
163MP0001963_abnormal_hearing_physiology0.63696496
164MP0000163_abnormal_cartilage_morphology0.63183108
165MP0002933_joint_inflammation0.62319413
166MP0002133_abnormal_respiratory_system0.62034673

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.91685497
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.55935575
3Concave nail (HP:0001598)4.22066325
4Pancreatic cysts (HP:0001737)3.85170419
5Abnormal hemoglobin (HP:0011902)3.77728953
6Congenital ichthyosiform erythroderma (HP:0007431)3.73700152
7Acute encephalopathy (HP:0006846)3.72062057
8Congenital sensorineural hearing impairment (HP:0008527)3.51982396
9Abnormal mitochondria in muscle tissue (HP:0008316)3.48993323
10Abnormality of secondary sexual hair (HP:0009888)3.46064574
11Abnormality of the axillary hair (HP:0100134)3.46064574
12Progressive macrocephaly (HP:0004481)3.44010523
13Pancreatic fibrosis (HP:0100732)3.42053478
14Abnormality of midbrain morphology (HP:0002418)3.40871139
15Molar tooth sign on MRI (HP:0002419)3.40871139
16Increased CSF lactate (HP:0002490)3.39539397
17Fragile nails (HP:0001808)3.30599297
18Reticulocytopenia (HP:0001896)3.27553854
19Premature rupture of membranes (HP:0001788)3.24073792
20Increased hepatocellular lipid droplets (HP:0006565)3.23295684
21Renal Fanconi syndrome (HP:0001994)3.20566644
22Macrocytic anemia (HP:0001972)3.20273611
23Aplasia involving bones of the extremities (HP:0009825)3.19689298
24Aplasia involving bones of the upper limbs (HP:0009823)3.19689298
25Aplasia of the phalanges of the hand (HP:0009802)3.19689298
26Congenital, generalized hypertrichosis (HP:0004540)3.18048086
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17042055
28True hermaphroditism (HP:0010459)3.16079851
29Hypotrichosis (HP:0001006)3.09133059
30Nephronophthisis (HP:0000090)3.09072247
31Chronic hepatic failure (HP:0100626)3.06777253
32Congenital stationary night blindness (HP:0007642)3.06753828
33Chin dimple (HP:0010751)3.02216465
34Woolly hair (HP:0002224)2.97583040
35Nonprogressive disorder (HP:0003680)2.94362098
36Hepatocellular necrosis (HP:0001404)2.94174373
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81729301
38Conical tooth (HP:0000698)2.80673193
39Hepatic necrosis (HP:0002605)2.74225317
40Upper limb muscle weakness (HP:0003484)2.72489604
41Aplasia cutis congenita (HP:0001057)2.69355401
42Abnormality of the renal medulla (HP:0100957)2.69178842
43Methylmalonic acidemia (HP:0002912)2.65206163
44Hypophosphatemic rickets (HP:0004912)2.63239803
45Methylmalonic aciduria (HP:0012120)2.61860873
46Cerebral edema (HP:0002181)2.60204218
47Sensory axonal neuropathy (HP:0003390)2.58271912
48Abnormality of the renal cortex (HP:0011035)2.57534204
49Abnormal pupillary function (HP:0007686)2.56616523
50Submucous cleft hard palate (HP:0000176)2.52168716
51Lipid accumulation in hepatocytes (HP:0006561)2.51603169
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50449997
53Obstructive sleep apnea (HP:0002870)2.48696576
54Glycosuria (HP:0003076)2.48639140
55Abnormality of urine glucose concentration (HP:0011016)2.48639140
56Adrenal hypoplasia (HP:0000835)2.48297626
57Nasolacrimal duct obstruction (HP:0000579)2.47280165
58Hyperglycinemia (HP:0002154)2.44655243
59Exertional dyspnea (HP:0002875)2.40687960
60Delayed CNS myelination (HP:0002188)2.40025911
61Pallor (HP:0000980)2.37234825
62Partial duplication of the phalanx of hand (HP:0009999)2.36951666
63Abnormality of cells of the erythroid lineage (HP:0012130)2.34676887
64Medial flaring of the eyebrow (HP:0010747)2.33418438
65Erythroderma (HP:0001019)2.30506918
66Rib fusion (HP:0000902)2.28376294
67Partial duplication of thumb phalanx (HP:0009944)2.28204550
68Symphalangism affecting the phalanges of the hand (HP:0009773)2.25884333
69Abnormal rod and cone electroretinograms (HP:0008323)2.25145265
70Coronal craniosynostosis (HP:0004440)2.23805855
71Lethargy (HP:0001254)2.23344684
72Cystic liver disease (HP:0006706)2.22172949
73Ridged nail (HP:0001807)2.21719667
74Tubular atrophy (HP:0000092)2.20750914
75Abnormality of placental membranes (HP:0011409)2.20740916
76Amniotic constriction ring (HP:0009775)2.20740916
77Sclerocornea (HP:0000647)2.19946048
78Xerostomia (HP:0000217)2.19267463
79Abnormal drinking behavior (HP:0030082)2.18916428
80Polydipsia (HP:0001959)2.18916428
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.17962685
82Absent/shortened dynein arms (HP:0200106)2.17962685
83Abnormality of renal resorption (HP:0011038)2.17902504
84Abnormal biliary tract physiology (HP:0012439)2.17554493
85Bile duct proliferation (HP:0001408)2.17554493
86Abolished electroretinogram (ERG) (HP:0000550)2.17549716
87Mitochondrial inheritance (HP:0001427)2.16433722
88Attenuation of retinal blood vessels (HP:0007843)2.14807266
89Pendular nystagmus (HP:0012043)2.14503324
90Septo-optic dysplasia (HP:0100842)2.13708065
91Type II lissencephaly (HP:0007260)2.12756264
92Peripheral hypomyelination (HP:0007182)2.11960302
93Abnormality of the middle phalanges of the toes (HP:0010183)2.11232664
94Cupped ear (HP:0000378)2.09157338
95Increased serum lactate (HP:0002151)2.08658801
96Renal cortical cysts (HP:0000803)2.07485301
97Abnormal number of erythroid precursors (HP:0012131)2.07195498
98Abnormality of dental color (HP:0011073)2.06576288
99Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04869318
100Alacrima (HP:0000522)2.04327041
101Down-sloping shoulders (HP:0200021)2.03945941
102Abnormality of the septum pellucidum (HP:0007375)2.03393399
103Synostosis involving the elbow (HP:0003938)2.03059501
104Humeroradial synostosis (HP:0003041)2.03059501
105Lactic acidosis (HP:0003128)2.02207461
106Absent septum pellucidum (HP:0001331)2.01066909
107White forelock (HP:0002211)1.99829046
108Abnormal ciliary motility (HP:0012262)1.99767742
109Polyuria (HP:0000103)1.99451957
110Prolonged partial thromboplastin time (HP:0003645)1.99215620
111Hyperglycinuria (HP:0003108)1.98485667
112Abnormality of the nasolacrimal system (HP:0000614)1.97692447
113Corneal dystrophy (HP:0001131)1.96852992
114Male pseudohermaphroditism (HP:0000037)1.96331261
115Hypothermia (HP:0002045)1.95978446
116Overfolded helix (HP:0000396)1.95962683
117Patchy hypopigmentation of hair (HP:0011365)1.95582331
118Hypoplastic pelvis (HP:0008839)1.95574141
119Abnormality of the pons (HP:0007361)1.94057710
120Abnormality of the 2nd finger (HP:0004100)1.94051597
121Aplasia/hypoplasia of the uterus (HP:0008684)1.92953472
122Anophthalmia (HP:0000528)1.92785301
123Dry hair (HP:0011359)1.91227057
124Sparse lateral eyebrow (HP:0005338)1.90871787
125Furrowed tongue (HP:0000221)1.90764133
126Abnormality of the lacrimal duct (HP:0011481)1.90738447
127Acute necrotizing encephalopathy (HP:0006965)1.90734320
128Large for gestational age (HP:0001520)1.89206135
129Breast hypoplasia (HP:0003187)1.88694156
130Myelomeningocele (HP:0002475)1.88466131
131Hypomagnesemia (HP:0002917)1.88138995
132Abnormality of vitamin B metabolism (HP:0004340)1.87982640
133Onycholysis (HP:0001806)1.87729104
134Anencephaly (HP:0002323)1.87081893
135Respiratory failure (HP:0002878)1.86568396
136Abnormality of incisor morphology (HP:0011063)1.86069448
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85134420
138Hypoplasia of the pons (HP:0012110)1.84154707
139Anhidrosis (HP:0000970)1.83951071
140Hypoplasia of the iris (HP:0007676)1.82813955
141Triphalangeal thumb (HP:0001199)1.82500883
142Type 2 muscle fiber atrophy (HP:0003554)1.82108685
143Duplication of thumb phalanx (HP:0009942)1.81286660
144Brittle hair (HP:0002299)1.81117996
145Hypobetalipoproteinemia (HP:0003563)1.79549395
146Absent thumb (HP:0009777)1.79351449
1473-Methylglutaconic aciduria (HP:0003535)1.79003290
148Seborrheic dermatitis (HP:0001051)1.78166169
149Abnormality of methionine metabolism (HP:0010901)1.77997044
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.76482398
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76482398
152Hyperlipoproteinemia (HP:0010980)1.76205238
153Split foot (HP:0001839)1.76144848
154Neurofibrillary tangles (HP:0002185)1.75979870
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74956627
156Hypoparathyroidism (HP:0000829)1.74510567
157Hypoalbuminemia (HP:0003073)1.74426214
158Abnormal albumin level (HP:0012116)1.74426214
159Bony spicule pigmentary retinopathy (HP:0007737)1.73291571
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.73251338
161Decreased lacrimation (HP:0000633)1.73200655
162Congenital hepatic fibrosis (HP:0002612)1.72962587
163Tracheomalacia (HP:0002779)1.72380743
164Natal tooth (HP:0000695)1.72347898
165Optic disc pallor (HP:0000543)1.72012310
166Abnormality of glycine metabolism (HP:0010895)1.71503781
167Abnormality of serine family amino acid metabolism (HP:0010894)1.71503781
168Abnormality of alanine metabolism (HP:0010916)1.70742283
169Hyperalaninemia (HP:0003348)1.70742283
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70742283
171Hyperphosphaturia (HP:0003109)1.70513981
172Increased intramyocellular lipid droplets (HP:0012240)1.69937420
173Abnormality of serum amino acid levels (HP:0003112)1.69569124
174Abnormal urine phosphate concentration (HP:0012599)1.69058028
175Decreased central vision (HP:0007663)1.67593465
176Ketosis (HP:0001946)1.66176076
177Abnormal urine output (HP:0012590)1.66085021
178Abnormality of the vitamin B12 metabolism (HP:0004341)1.65616143
179Tachypnea (HP:0002789)1.64177472
180Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62794467
181Nephrogenic diabetes insipidus (HP:0009806)1.62509625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.20956611
2CASK4.01439449
3FRK3.57415156
4STK393.46273256
5PBK3.22451727
6MST42.48692485
7MKNK22.44642130
8OXSR12.28829069
9WNK32.19342944
10BMPR1B2.11283853
11TXK2.08350494
12EPHB22.07447144
13PINK11.86271949
14FES1.85539208
15PKN11.84381381
16BCR1.75870487
17MAPKAPK51.75613029
18VRK21.70014160
19FER1.61238525
20NUAK11.55956844
21MKNK11.55443418
22BLK1.53471723
23INSRR1.52484822
24CDK191.49722780
25IRAK11.49343235
26TAOK31.49117377
27CLK11.46753494
28MAPK131.46137402
29BCKDK1.43462079
30IRAK41.40642787
31ACVR1B1.37954134
32BMPR21.37439153
33FGR1.36937676
34TRIM281.36309200
35IRAK21.35815221
36MAP4K21.31544438
37NME21.30483781
38DMPK1.29768808
39MAPKAPK31.27645921
40FGFR21.26991335
41MAPK151.25131541
42PDK21.22427013
43STK161.20476740
44WNK41.15901399
45MET1.15070082
46MAP2K21.13748549
47MAP3K121.13484574
48EPHB11.13355846
49PAK31.11715787
50PRKCG1.10347173
51TNIK1.08951842
52MAP2K61.08708440
53NEK61.08595035
54BUB11.07636683
55CDK31.07415887
56PIM21.04280594
57CAMK2B1.02074418
58PHKG20.95600473
59PHKG10.95600473
60TSSK60.94911354
61GRK10.93810861
62DYRK20.91850117
63VRK10.91376152
64WEE10.90002515
65CAMK2D0.89504624
66TAF10.89238713
67NME10.89035905
68DAPK20.88900309
69MAP3K40.88299405
70YES10.86899593
71PIK3CA0.86094256
72MUSK0.86004567
73GRK70.85688969
74IRAK30.85054347
75PNCK0.85032313
76TIE10.84282387
77CDK90.83954942
78NLK0.83803674
79PRPF4B0.81827406
80PRKCE0.80182929
81STK240.79403730
82RPS6KA50.78599537
83CSK0.76617402
84NTRK30.74792023
85UHMK10.74289377
86GRK50.74289223
87ADRBK20.73971739
88EPHA40.73665805
89CAMK2A0.73379940
90PLK30.71873197
91HIPK20.71025290
92PRKD20.68286142
93WNK10.68213718
94ADRBK10.68073211
95CDC70.64684243
96PLK40.64460383
97CAMK2G0.63647799
98LIMK10.63015583
99PLK20.63010547
100EIF2AK10.61859649
101PRKCI0.61155173
102ROCK20.60624632
103PIK3CG0.60568883
104DAPK30.60230670
105TESK20.58864749
106EIF2AK20.57829908
107CSNK1G30.57392644
108SRPK10.56726552
109RIPK40.55426432
110BRSK20.53910914
111CSNK1G20.53865038
112EPHA20.53544287
113CSNK1A1L0.53262603
114TGFBR10.52942340
115ABL20.52265077
116CSNK1G10.51906434
117PRKACA0.51448970
118AKT30.50801832
119STK38L0.50011869
120MST1R0.49801277
121PRKG10.48732459
122MARK20.48439503
123NEK90.47290438
124MAP3K140.46296323
125STK110.43793742
126EIF2AK30.43426602
127PRKD10.41182733
128PRKCQ0.41084287
129TRPM70.40220739
130CSNK1A10.39909844
131PTK2B0.39845601
132CSNK2A10.39772234
133DYRK1A0.39641461
134TEC0.39589129
135CDK140.38883114
136LCK0.38819194
137CDK80.37919100
138GRK60.37823585
139IKBKB0.37048758
140CSNK2A20.36582225
141ITK0.36203713
142PRKCA0.35807540
143ZAK0.35069353
144PLK10.33864449
145MAP2K70.32852322
146MAPK40.32557621
147STK30.32386810
148DYRK1B0.32029082
149CHUK0.31555167
150PRKACB0.28745645
151FGFR10.28395261
152CHEK20.28382886
153CSNK1E0.27667445
154PASK0.26748165

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.04145723
2Oxidative phosphorylation_Homo sapiens_hsa001903.09656671
3Protein export_Homo sapiens_hsa030603.05261667
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.74250052
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44314282
6Sphingolipid metabolism_Homo sapiens_hsa006002.43641444
7Steroid biosynthesis_Homo sapiens_hsa001002.31010678
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26338552
9Ether lipid metabolism_Homo sapiens_hsa005652.25315802
10Parkinsons disease_Homo sapiens_hsa050122.17887432
11Caffeine metabolism_Homo sapiens_hsa002322.04382531
12Fatty acid elongation_Homo sapiens_hsa000622.00345892
13Alzheimers disease_Homo sapiens_hsa050101.99304537
14Proteasome_Homo sapiens_hsa030501.94313560
15RNA polymerase_Homo sapiens_hsa030201.85210232
16Butanoate metabolism_Homo sapiens_hsa006501.80999772
17Linoleic acid metabolism_Homo sapiens_hsa005911.76777126
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64156751
19Phototransduction_Homo sapiens_hsa047441.62162381
20Arachidonic acid metabolism_Homo sapiens_hsa005901.60787963
21Axon guidance_Homo sapiens_hsa043601.59168454
22Huntingtons disease_Homo sapiens_hsa050161.58421604
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.57251141
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57081156
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51305407
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50089454
27Nitrogen metabolism_Homo sapiens_hsa009101.48188072
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43878617
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37264591
30Serotonergic synapse_Homo sapiens_hsa047261.32981391
31Fat digestion and absorption_Homo sapiens_hsa049751.32263228
32Peroxisome_Homo sapiens_hsa041461.31160502
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27051412
34Tryptophan metabolism_Homo sapiens_hsa003801.25040470
35Basal transcription factors_Homo sapiens_hsa030221.24222477
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24098583
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23787036
38Long-term depression_Homo sapiens_hsa047301.20342888
39Selenocompound metabolism_Homo sapiens_hsa004501.18725164
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13569850
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13414044
42Histidine metabolism_Homo sapiens_hsa003401.13125460
43Cardiac muscle contraction_Homo sapiens_hsa042601.12670240
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09823769
45Graft-versus-host disease_Homo sapiens_hsa053321.08465459
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07363322
47RNA degradation_Homo sapiens_hsa030181.03986421
48Sulfur metabolism_Homo sapiens_hsa009201.03804489
49Mineral absorption_Homo sapiens_hsa049781.03284358
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02487533
51One carbon pool by folate_Homo sapiens_hsa006701.02082285
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00975190
53Homologous recombination_Homo sapiens_hsa034400.99987121
54Propanoate metabolism_Homo sapiens_hsa006400.99369874
55Hedgehog signaling pathway_Homo sapiens_hsa043400.98659776
56Ras signaling pathway_Homo sapiens_hsa040140.98602347
57Tight junction_Homo sapiens_hsa045300.97486020
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97180469
59Malaria_Homo sapiens_hsa051440.96269061
60Fatty acid degradation_Homo sapiens_hsa000710.96000393
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92169778
62Rheumatoid arthritis_Homo sapiens_hsa053230.91690105
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90592570
64Basal cell carcinoma_Homo sapiens_hsa052170.88643125
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87574607
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87389111
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85446215
68Wnt signaling pathway_Homo sapiens_hsa043100.84795295
69Metabolic pathways_Homo sapiens_hsa011000.84732338
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.83866290
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.82719272
72Autoimmune thyroid disease_Homo sapiens_hsa053200.81386431
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81374859
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80999296
75Fanconi anemia pathway_Homo sapiens_hsa034600.80922557
76Pyrimidine metabolism_Homo sapiens_hsa002400.78530440
77Melanogenesis_Homo sapiens_hsa049160.77389136
78Retinol metabolism_Homo sapiens_hsa008300.76181303
79Complement and coagulation cascades_Homo sapiens_hsa046100.75707999
80Melanoma_Homo sapiens_hsa052180.72220512
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.71045187
82Sulfur relay system_Homo sapiens_hsa041220.70691964
83Renal cell carcinoma_Homo sapiens_hsa052110.70438808
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69978300
85Purine metabolism_Homo sapiens_hsa002300.69786639
86Regulation of autophagy_Homo sapiens_hsa041400.69708401
87Glutamatergic synapse_Homo sapiens_hsa047240.69692800
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.67825818
89Olfactory transduction_Homo sapiens_hsa047400.64627878
90Ovarian steroidogenesis_Homo sapiens_hsa049130.64008599
91TGF-beta signaling pathway_Homo sapiens_hsa043500.62998270
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62124736
93Hematopoietic cell lineage_Homo sapiens_hsa046400.62115644
94beta-Alanine metabolism_Homo sapiens_hsa004100.61900774
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.58124982
96ECM-receptor interaction_Homo sapiens_hsa045120.58113927
97Tyrosine metabolism_Homo sapiens_hsa003500.54351135
98Prostate cancer_Homo sapiens_hsa052150.54070031
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53569641
100ABC transporters_Homo sapiens_hsa020100.53343828
101Arginine biosynthesis_Homo sapiens_hsa002200.50790008
102Nicotine addiction_Homo sapiens_hsa050330.50443439
103ErbB signaling pathway_Homo sapiens_hsa040120.50434357
104Allograft rejection_Homo sapiens_hsa053300.50421274
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.49753323
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.49633569
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49140351
108Asthma_Homo sapiens_hsa053100.48766941
109Renin secretion_Homo sapiens_hsa049240.46791786
110Glycerolipid metabolism_Homo sapiens_hsa005610.46702299
111Collecting duct acid secretion_Homo sapiens_hsa049660.46593053
112Morphine addiction_Homo sapiens_hsa050320.46432108
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.45899558
114Hippo signaling pathway_Homo sapiens_hsa043900.44936457
115Taste transduction_Homo sapiens_hsa047420.44623250
116Glutathione metabolism_Homo sapiens_hsa004800.41400749
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40761716
118Bile secretion_Homo sapiens_hsa049760.40433508
119Primary immunodeficiency_Homo sapiens_hsa053400.40173944
120Fatty acid metabolism_Homo sapiens_hsa012120.39875945
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39792273
122Insulin secretion_Homo sapiens_hsa049110.39254316
123Salivary secretion_Homo sapiens_hsa049700.38962320
124Mismatch repair_Homo sapiens_hsa034300.38767352
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38593681
126GABAergic synapse_Homo sapiens_hsa047270.37967384
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37958264
128Choline metabolism in cancer_Homo sapiens_hsa052310.37640380
129Rap1 signaling pathway_Homo sapiens_hsa040150.37594718
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.37220877
131Chemical carcinogenesis_Homo sapiens_hsa052040.37204600
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36641422
133Nucleotide excision repair_Homo sapiens_hsa034200.36631764
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36435081
135Arginine and proline metabolism_Homo sapiens_hsa003300.35295802
136Pancreatic secretion_Homo sapiens_hsa049720.34890141
137Cholinergic synapse_Homo sapiens_hsa047250.34475757
138African trypanosomiasis_Homo sapiens_hsa051430.34293593
139Spliceosome_Homo sapiens_hsa030400.33488682
140Starch and sucrose metabolism_Homo sapiens_hsa005000.32744145
141Vibrio cholerae infection_Homo sapiens_hsa051100.32684312
142PPAR signaling pathway_Homo sapiens_hsa033200.32373565
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31641535
144Phagosome_Homo sapiens_hsa041450.31539872
145Salmonella infection_Homo sapiens_hsa051320.31360015
146Folate biosynthesis_Homo sapiens_hsa007900.30967140
147Vitamin digestion and absorption_Homo sapiens_hsa049770.30914112
148Pyruvate metabolism_Homo sapiens_hsa006200.29983944

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