CAPN13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.95933492
2intestinal absorption (GO:0050892)8.42102299
3cilium movement (GO:0003341)8.29610152
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39309784
5intestinal cholesterol absorption (GO:0030299)6.86804432
6imidazole-containing compound metabolic process (GO:0052803)6.84585748
7maintenance of gastrointestinal epithelium (GO:0030277)6.73090330
8epithelial cilium movement (GO:0003351)6.60988822
9motile cilium assembly (GO:0044458)6.47271183
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.17277189
11angiotensin maturation (GO:0002003)6.09354392
12peptide catabolic process (GO:0043171)5.77731984
13hydrogen peroxide catabolic process (GO:0042744)5.55625367
14thyroid hormone metabolic process (GO:0042403)5.51050897
15UDP-N-acetylglucosamine metabolic process (GO:0006047)5.47988116
16axoneme assembly (GO:0035082)5.43188510
17digestive system process (GO:0022600)5.08679046
18epithelial structure maintenance (GO:0010669)5.05628490
19O-glycan processing (GO:0016266)4.95961926
20positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.92336164
21primary alcohol catabolic process (GO:0034310)4.67758420
22positive regulation of Cdc42 GTPase activity (GO:0043089)4.65444572
23leukotriene biosynthetic process (GO:0019370)4.64333595
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.58670420
253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.58670420
26regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.57137154
27vitamin A metabolic process (GO:0006776)4.52525529
28thyroid hormone generation (GO:0006590)4.52006363
29adhesion of symbiont to host cell (GO:0044650)4.47184926
30virion attachment to host cell (GO:0019062)4.47184926
31epoxygenase P450 pathway (GO:0019373)4.44100861
32hydrogen peroxide metabolic process (GO:0042743)4.44011867
33phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.43046538
34intestinal epithelial cell development (GO:0060576)4.32552315
35digestion (GO:0007586)4.29646586
36actin filament depolymerization (GO:0030042)4.25214723
37regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.14745448
38sulfate transmembrane transport (GO:1902358)4.12822977
39leukotriene metabolic process (GO:0006691)4.11202938
40antibacterial humoral response (GO:0019731)4.09509185
41multicellular organismal water homeostasis (GO:0050891)4.07658269
42positive regulation of glycoprotein biosynthetic process (GO:0010560)4.02069106
43antimicrobial humoral response (GO:0019730)4.00304040
44sulfation (GO:0051923)3.99814397
45left/right axis specification (GO:0070986)3.97074380
46positive regulation of respiratory burst (GO:0060267)3.95222797
47diterpenoid biosynthetic process (GO:0016102)3.91077002
48bile acid and bile salt transport (GO:0015721)3.88620108
49pyrimidine-containing compound transmembrane transport (GO:0072531)3.78924891
50sphingomyelin metabolic process (GO:0006684)3.78129298
51response to nitric oxide (GO:0071731)3.76211648
52regulation of guanylate cyclase activity (GO:0031282)3.74545806
53vitamin transmembrane transport (GO:0035461)3.69057691
54phospholipid scrambling (GO:0017121)3.67639743
55drug catabolic process (GO:0042737)3.66764556
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66418432
57negative regulation of hormone metabolic process (GO:0032351)3.65953523
58water homeostasis (GO:0030104)3.64352881
59flavonoid metabolic process (GO:0009812)3.64154595
60positive regulation of glycoprotein metabolic process (GO:1903020)3.61145158
61hormone catabolic process (GO:0042447)3.59849193
62adhesion of symbiont to host (GO:0044406)3.59734397
63regulation of interleukin-8 biosynthetic process (GO:0045414)3.58745462
64regulation of cilium movement (GO:0003352)3.58132835
65fructose metabolic process (GO:0006000)3.57370862
66regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.57324302
67endocrine process (GO:0050886)3.57324302
68regulation of systemic arterial blood pressure by hormone (GO:0001990)3.57324302
69fat-soluble vitamin biosynthetic process (GO:0042362)3.54652202
70drug metabolic process (GO:0017144)3.53968682
71regulation of lipoprotein particle clearance (GO:0010984)3.45613174
72L-fucose catabolic process (GO:0042355)3.45207999
73fucose catabolic process (GO:0019317)3.45207999
74L-fucose metabolic process (GO:0042354)3.45207999
75hemidesmosome assembly (GO:0031581)3.42768153
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.41817539
77negative regulation of hormone biosynthetic process (GO:0032353)3.40112320
78ventricular system development (GO:0021591)3.39411383
79transcytosis (GO:0045056)3.39075027
80cellular glucuronidation (GO:0052695)3.37566328
81ethanol oxidation (GO:0006069)3.33846424
82lipoprotein transport (GO:0042953)3.32264413
83one-carbon compound transport (GO:0019755)3.29365232
84glucuronate metabolic process (GO:0019585)3.28490229
85uronic acid metabolic process (GO:0006063)3.28490229
86sodium ion homeostasis (GO:0055078)3.26340495
87diacylglycerol metabolic process (GO:0046339)3.26185579
88regulation of bile acid biosynthetic process (GO:0070857)3.25066349
89ventricular cardiac muscle cell action potential (GO:0086005)3.23717037
90sulfate transport (GO:0008272)3.20810661
91peptide hormone processing (GO:0016486)3.19282009
92sperm capacitation (GO:0048240)3.18308581
93negative regulation of sterol transport (GO:0032372)3.17744430
94negative regulation of cholesterol transport (GO:0032375)3.17744430
95protein O-linked glycosylation (GO:0006493)3.17302663
96negative regulation of interleukin-10 production (GO:0032693)3.16244838
97excretion (GO:0007588)3.16038027
98response to hepatocyte growth factor (GO:0035728)3.15399247
99cellular response to hepatocyte growth factor stimulus (GO:0035729)3.15399247
100hepatocyte apoptotic process (GO:0097284)3.15149969
101desmosome organization (GO:0002934)3.14357856
102left/right pattern formation (GO:0060972)3.13598074
103positive regulation of receptor biosynthetic process (GO:0010870)3.12617179
104exogenous drug catabolic process (GO:0042738)3.12430466
105regulation of protein glycosylation (GO:0060049)3.11167458
106sulfur compound transport (GO:0072348)3.09994211
107nucleotide-sugar biosynthetic process (GO:0009226)3.09389764
108regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.08473682
109retinal cone cell development (GO:0046549)3.07984371
110regulation of systemic arterial blood pressure (GO:0003073)3.07371635
111L-ascorbic acid metabolic process (GO:0019852)3.06704801
112regulation of T-helper 1 cell differentiation (GO:0045625)3.05082332
113homocysteine metabolic process (GO:0050667)3.04390358
114modified amino acid transport (GO:0072337)3.03938395
115defense response to fungus (GO:0050832)3.03600216
116columnar/cuboidal epithelial cell development (GO:0002066)3.01993438
117regulation of proton transport (GO:0010155)3.01745501
118superoxide anion generation (GO:0042554)2.98549173
119protein autoprocessing (GO:0016540)2.98196885
120positive regulation of antigen processing and presentation (GO:0002579)2.95451668
121transepithelial transport (GO:0070633)2.94501838
122retinoic acid metabolic process (GO:0042573)2.94437311
123microtubule bundle formation (GO:0001578)2.92371263
124intraciliary transport (GO:0042073)2.91752033
125macroautophagy (GO:0016236)2.91677928
126glycine transport (GO:0015816)2.91127277
127dendritic cell differentiation (GO:0097028)2.90853798
128myeloid dendritic cell differentiation (GO:0043011)2.89951860
129killing of cells of other organism (GO:0031640)2.89818633
130disruption of cells of other organism (GO:0044364)2.89818633
131phenylpropanoid metabolic process (GO:0009698)2.89034960
132bicarbonate transport (GO:0015701)2.87320685
133lung vasculature development (GO:0060426)2.85969159
134cilium organization (GO:0044782)2.84003016
135regulation of cholesterol homeostasis (GO:2000188)2.83919335
136neurotransmitter biosynthetic process (GO:0042136)2.83811266
137calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.81734921
138regulation of acrosome reaction (GO:0060046)2.81547671
139glandular epithelial cell differentiation (GO:0002067)2.81252080
140regulation of type B pancreatic cell apoptotic process (GO:2000674)2.81232093
141nucleoside diphosphate biosynthetic process (GO:0009133)2.80385300
142regulation of interleukin-5 production (GO:0032674)2.78968799
143auditory receptor cell differentiation (GO:0042491)2.78223267
144fucose metabolic process (GO:0006004)2.78198892
145glycerol metabolic process (GO:0006071)2.78170573
146tight junction assembly (GO:0070830)2.75840437
147GDP-mannose metabolic process (GO:0019673)2.75595342
148ethanol metabolic process (GO:0006067)2.75046537
149eosinophil migration (GO:0072677)2.74931638
150nucleotide-sugar metabolic process (GO:0009225)2.74118864
151endocrine pancreas development (GO:0031018)2.74090068
152dendritic cell chemotaxis (GO:0002407)2.74014606
153primary alcohol metabolic process (GO:0034308)2.74003090
154positive regulation of guanylate cyclase activity (GO:0031284)2.73631359
155membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.72376674
156oligosaccharide biosynthetic process (GO:0009312)2.71861115
157lung lobe morphogenesis (GO:0060463)2.71087241
158intermediate filament organization (GO:0045109)2.70628511
159multicellular organism reproduction (GO:0032504)2.69817595
160innate immune response in mucosa (GO:0002227)2.68520197
161vitamin transport (GO:0051180)2.68411972
162retinol metabolic process (GO:0042572)2.67862691
163cilium assembly (GO:0042384)2.67507526
164regulation of interleukin-13 production (GO:0032656)2.67039189
165glutathione derivative biosynthetic process (GO:1901687)2.66877641
166NADH metabolic process (GO:0006734)2.66795700
167biotin metabolic process (GO:0006768)2.65646917
168keratinocyte proliferation (GO:0043616)2.65340357
169glutathione derivative metabolic process (GO:1901685)2.65246635
170positive regulation of glycolytic process (GO:0045821)2.64449606
171oocyte development (GO:0048599)2.63621101
172glutathione biosynthetic process (GO:0006750)2.62417829
173COPII vesicle coating (GO:0048208)2.59819509
174phenol-containing compound catabolic process (GO:0019336)2.55939653
175ear development (GO:0043583)2.55183343
176cilium or flagellum-dependent cell motility (GO:0001539)10.4853580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.72968380
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.09016219
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.76863600
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20376484
5GATA4_25053715_ChIP-Seq_YYC3_Human2.76090244
6SOX2_20726797_ChIP-Seq_SW620_Human2.74901913
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.48206605
8GATA6_25053715_ChIP-Seq_YYC3_Human2.43074730
9VDR_22108803_ChIP-Seq_LS180_Human2.39198586
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38803319
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.34587374
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.33203219
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25848918
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.16002652
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07567200
16* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06189434
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.03275438
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98008597
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96673035
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93477165
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90557074
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90079455
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83754555
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83696858
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82220944
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80893327
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.79534139
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78308036
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77818558
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76633884
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73273276
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.71708060
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.66147015
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.59502816
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56222479
36KLF5_25053715_ChIP-Seq_YYC3_Human1.56034913
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55747644
38RACK7_27058665_Chip-Seq_MCF-7_Human1.54626141
39* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52601850
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52219987
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50967588
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.49295473
43TP63_23658742_ChIP-Seq_EP156T_Human1.46946764
44* FOXO3_23340844_ChIP-Seq_DLD1_Human1.44948875
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40908869
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.39752331
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37199108
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36782902
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36634998
50BCAT_22108803_ChIP-Seq_LS180_Human1.35817428
51EGR1_19032775_ChIP-ChIP_M12_Human1.34560524
52SMAD3_21741376_ChIP-Seq_HESCs_Human1.28114982
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25713711
54FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.25512139
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23427243
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23362692
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20005883
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19649101
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19573868
60TCF4_22108803_ChIP-Seq_LS180_Human1.18505567
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.16695094
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.15766728
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12977053
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11022211
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09491482
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08558131
67* ETV1_20927104_ChIP-Seq_GIST48_Human1.07783073
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07710752
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06716985
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06716985
71KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06683080
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06335449
73TP53_18474530_ChIP-ChIP_U2OS_Human1.05549093
74* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05034103
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04431757
76GATA2_19941826_ChIP-Seq_K562_Human1.04030972
77GATA1_22025678_ChIP-Seq_K562_Human1.03621240
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.03381295
79AR_25329375_ChIP-Seq_VCAP_Human1.03242657
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02654245
81* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01872365
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00697908
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.00524091
84ER_23166858_ChIP-Seq_MCF-7_Human1.00503623
85STAT3_23295773_ChIP-Seq_U87_Human1.00396985
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99383698
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.98914077
88RXR_22108803_ChIP-Seq_LS180_Human0.98727769
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98298270
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97975990
91TBL1_22424771_ChIP-Seq_293T_Human0.97931867
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97820803
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97570758
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97208749
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.97208749
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97148308
97CBP_21632823_ChIP-Seq_H3396_Human0.96833424
98PHF8_20622853_ChIP-Seq_HELA_Human0.96739523
99* RBPJ_21746931_ChIP-Seq_IB4_Human0.96689823
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96613739
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96348026
102* AR_20517297_ChIP-Seq_VCAP_Human0.95387199
103TCF4_23295773_ChIP-Seq_U87_Human0.94857653
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94802308
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.94614488
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94511089
107* HNF4A_19822575_ChIP-Seq_HepG2_Human0.93565128
108* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93472913
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.92635117
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91704103
111NFYB_21822215_ChIP-Seq_K562_Human0.91694867
112* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91543366
113LXR_22292898_ChIP-Seq_THP-1_Human0.91296936
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91108786
115SMRT_27268052_Chip-Seq_Bcells_Human0.90956946
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90346298
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90312644
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90162209
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89930287
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89721232
121CLOCK_20551151_ChIP-Seq_293T_Human0.89510860
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89487396
123* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89374660
124* CBP_20019798_ChIP-Seq_JUKART_Human0.89374660
125AHR_22903824_ChIP-Seq_MCF-7_Human0.88810993
126CJUN_26792858_Chip-Seq_BT549_Human0.88522469
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88281525
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88200092
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88022203
130ATF3_27146783_Chip-Seq_COLON_Human0.87368279
131* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86582711
132* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86264726
133CDX2_22108803_ChIP-Seq_LS180_Human0.86150144
134CREB1_26743006_Chip-Seq_LNCaP_Human0.86004104
135* GATA3_24758297_ChIP-Seq_MCF-7_Human0.85956237
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85131711
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83341972
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83320765
139AR_21909140_ChIP-Seq_LNCAP_Human0.81997610
140SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80357367
141CTCF_27219007_Chip-Seq_Bcells_Human0.79967236
142* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79747484
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78027165
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76578091
145* STAT1_17558387_ChIP-Seq_HELA_Human0.75985294
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75304041
147TP63_22573176_ChIP-Seq_HFKS_Human0.74010638
148NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73761555
149TP53_16413492_ChIP-PET_HCT116_Human0.73679740
150DROSHA_22980978_ChIP-Seq_HELA_Human0.72900948
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72193618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.22522395
2MP0005360_urolithiasis6.22301946
3MP0002876_abnormal_thyroid_physiology4.63837997
4MP0001666_abnormal_nutrient_absorption4.30476192
5MP0010234_abnormal_vibrissa_follicle4.04694229
6MP0001873_stomach_inflammation3.94806272
7MP0004264_abnormal_extraembryonic_tissu3.47145751
8MP0001664_abnormal_digestion3.14056116
9MP0003718_maternal_effect3.03340514
10MP0000462_abnormal_digestive_system3.01947599
11MP0000566_synostosis2.99380105
12MP0003866_abnormal_defecation2.93784402
13MP0005085_abnormal_gallbladder_physiolo2.68186362
14MP0001663_abnormal_digestive_system2.60914071
15MP0005381_digestive/alimentary_phenotyp2.43655443
16MP0010155_abnormal_intestine_physiology2.34748091
17MP0002877_abnormal_melanocyte_morpholog2.32084931
18MP0003195_calcinosis2.29076582
19MP0000678_abnormal_parathyroid_gland2.28292428
20MP0005645_abnormal_hypothalamus_physiol2.25745302
21MP0003806_abnormal_nucleotide_metabolis2.23449369
22MP0000470_abnormal_stomach_morphology2.17303530
23MP0003183_abnormal_peptide_metabolism2.11830519
24MP0000538_abnormal_urinary_bladder2.06376851
25MP0005395_other_phenotype1.89038430
26MP0000537_abnormal_urethra_morphology1.88634542
27MP0002254_reproductive_system_inflammat1.87127156
28MP0005310_abnormal_salivary_gland1.75198878
29MP0000477_abnormal_intestine_morphology1.71908846
30MP0002139_abnormal_hepatobiliary_system1.71038840
31MP0006054_spinal_hemorrhage1.70828469
32MP0000490_abnormal_crypts_of1.70536252
33MP0010386_abnormal_urinary_bladder1.67180176
34MP0004782_abnormal_surfactant_physiolog1.67010236
35MP0002653_abnormal_ependyma_morphology1.62130106
36MP0008875_abnormal_xenobiotic_pharmacok1.55992880
37MP0003868_abnormal_feces_composition1.55306250
38MP0010329_abnormal_lipoprotein_level1.53535744
39MP0004147_increased_porphyrin_level1.53529641
40MP0003252_abnormal_bile_duct1.52938593
41MP0004510_myositis1.52421810
42MP0002132_abnormal_respiratory_system1.48398192
43MP0009379_abnormal_foot_pigmentation1.46949273
44MP0010352_gastrointestinal_tract_polyps1.45850689
45MP0003300_gastrointestinal_ulcer1.40122830
46MP0003879_abnormal_hair_cell1.39666359
47MP0000383_abnormal_hair_follicle1.39068594
48MP0003705_abnormal_hypodermis_morpholog1.37899766
49MP0005409_darkened_coat_color1.37815830
50MP0005367_renal/urinary_system_phenotyp1.36335318
51MP0000516_abnormal_urinary_system1.36335318
52MP0009840_abnormal_foam_cell1.33736073
53MP0005365_abnormal_bile_salt1.29786988
54MP0000685_abnormal_immune_system1.27102945
55MP0002822_catalepsy1.20910991
56MP0001188_hyperpigmentation1.20160526
57MP0003283_abnormal_digestive_organ1.19237863
58MP0004019_abnormal_vitamin_homeostasis1.18281046
59MP0009643_abnormal_urine_homeostasis1.16722119
60MP0003453_abnormal_keratinocyte_physiol1.15885325
61MP0002735_abnormal_chemical_nociception1.15190419
62MP0004133_heterotaxia1.14958337
63MP0000427_abnormal_hair_cycle1.13946406
64MP0000003_abnormal_adipose_tissue1.12572312
65MP0004043_abnormal_pH_regulation1.12450896
66MP0008789_abnormal_olfactory_epithelium1.11415205
67MP0002168_other_aberrant_phenotype1.10091538
68MP0000681_abnormal_thyroid_gland1.09827559
69MP0001944_abnormal_pancreas_morphology1.09730899
70MP0001764_abnormal_homeostasis1.07291704
71MP0000467_abnormal_esophagus_morphology1.06814560
72MP0001984_abnormal_olfaction1.05417813
73MP0010678_abnormal_skin_adnexa1.05151399
74MP0001765_abnormal_ion_homeostasis1.02495723
75MP0002160_abnormal_reproductive_system1.02464086
76MP0002796_impaired_skin_barrier0.99124697
77MP0005448_abnormal_energy_balance0.96331494
78MP0003953_abnormal_hormone_level0.93081384
79MP0008872_abnormal_physiological_respon0.92625339
80MP0002078_abnormal_glucose_homeostasis0.91247029
81MP0002909_abnormal_adrenal_gland0.90268312
82MP0004947_skin_inflammation0.90245504
83MP0002693_abnormal_pancreas_physiology0.90209637
84MP0009764_decreased_sensitivity_to0.87436656
85MP0005084_abnormal_gallbladder_morpholo0.86301134
86MP0002138_abnormal_hepatobiliary_system0.86098966
87MP0001849_ear_inflammation0.86021740
88MP0004270_analgesia0.85751110
89MP0003638_abnormal_response/metabolism_0.85675466
90MP0002098_abnormal_vibrissa_morphology0.84041734
91MP0005636_abnormal_mineral_homeostasis0.81969978
92MP0009115_abnormal_fat_cell0.80316549
93MP0001502_abnormal_circadian_rhythm0.79587232
94MP0008877_abnormal_DNA_methylation0.78918513
95MP0002277_abnormal_respiratory_mucosa0.77518697
96MP0003941_abnormal_skin_development0.75937278
97MP0005646_abnormal_pituitary_gland0.74921562
98MP0005166_decreased_susceptibility_to0.74388364
99MP0001501_abnormal_sleep_pattern0.74224952
100MP0002638_abnormal_pupillary_reflex0.72681988
101MP0005670_abnormal_white_adipose0.72581713
102MP0005165_increased_susceptibility_to0.69573335
103MP0005499_abnormal_olfactory_system0.67677950
104MP0005394_taste/olfaction_phenotype0.67677950
105MP0005451_abnormal_body_composition0.67611761
106MP0005083_abnormal_biliary_tract0.67275150
107MP0005408_hypopigmentation0.67164128
108MP0000627_abnormal_mammary_gland0.66902951
109MP0002118_abnormal_lipid_homeostasis0.66582251
110MP0002971_abnormal_brown_adipose0.65687772
111MP0001216_abnormal_epidermal_layer0.64746420
112MP0005501_abnormal_skin_physiology0.64491649
113MP0002136_abnormal_kidney_physiology0.64490478
114MP0009642_abnormal_blood_homeostasis0.64242098
115MP0001835_abnormal_antigen_presentation0.63949701
116MP0001881_abnormal_mammary_gland0.63515705
117MP0009780_abnormal_chondrocyte_physiolo0.62993490
118MP0000613_abnormal_salivary_gland0.62043039
119MP0000230_abnormal_systemic_arterial0.61939370
120MP0001845_abnormal_inflammatory_respons0.60727567
121MP0005389_reproductive_system_phenotype0.60445832
122MP0003890_abnormal_embryonic-extraembry0.59422944
123MP0005025_abnormal_response_to0.58699339
124MP0002060_abnormal_skin_morphology0.58432209
125MP0005220_abnormal_exocrine_pancreas0.57983342
126MP0005671_abnormal_response_to0.57791254
127MP0003950_abnormal_plasma_membrane0.57590094
128MP0005551_abnormal_eye_electrophysiolog0.57263059
129MP0005464_abnormal_platelet_physiology0.56791882
130MP0003191_abnormal_cellular_cholesterol0.56450616
131MP0002896_abnormal_bone_mineralization0.56240923
132MP0009697_abnormal_copulation0.56062966
133MP0001929_abnormal_gametogenesis0.55861027
134MP0000609_abnormal_liver_physiology0.54118231
135MP0005377_hearing/vestibular/ear_phenot0.53302013
136MP0003878_abnormal_ear_physiology0.53302013
137MP0005332_abnormal_amino_acid0.52605003
138MP0003936_abnormal_reproductive_system0.52243558
139MP0005319_abnormal_enzyme/_coenzyme0.51661655
140MP0003938_abnormal_ear_development0.51053028
141MP0000534_abnormal_ureter_morphology0.51012152
142MP0001756_abnormal_urination0.50091951
143MP0003959_abnormal_lean_body0.50044979
144MP0000377_abnormal_hair_follicle0.46746986
145MP0001485_abnormal_pinna_reflex0.45031554
146MP0004484_altered_response_of0.44653405
147MP0003045_fibrosis0.42916004

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.67994936
2Abnormal ciliary motility (HP:0012262)7.76173414
3Abnormal respiratory motile cilium physiology (HP:0012261)7.71056192
4Absent/shortened dynein arms (HP:0200106)7.66187346
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.66187346
6Abnormal respiratory motile cilium morphology (HP:0005938)7.43450382
7Abnormal respiratory epithelium morphology (HP:0012253)7.43450382
8Rhinitis (HP:0012384)7.20684772
9Right ventricular cardiomyopathy (HP:0011663)7.18204784
10Chronic bronchitis (HP:0004469)6.22559537
11Ileus (HP:0002595)6.01521411
12Bronchiectasis (HP:0002110)5.36313505
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.98358917
14Goiter (HP:0000853)4.88155165
15Nasal polyposis (HP:0100582)4.43516028
16Hyperglycinuria (HP:0003108)4.43371296
17Hyperactive renin-angiotensin system (HP:0000841)4.29929471
18Decreased circulating renin level (HP:0003351)4.08448549
19Malnutrition (HP:0004395)3.99816181
20Pustule (HP:0200039)3.87163027
21Hypoglycemic seizures (HP:0002173)3.83414458
22Hydroxyprolinuria (HP:0003080)3.78919585
23Abnormality of proline metabolism (HP:0010907)3.78919585
24Abnormality of the nasal mucosa (HP:0000433)3.77937833
25Bronchitis (HP:0012387)3.70188433
26Hypoglycemic coma (HP:0001325)3.67918168
27Confusion (HP:0001289)3.64040653
28Increased IgE level (HP:0003212)3.61865299
29Abnormality of the gastric mucosa (HP:0004295)3.52459071
30Abdominal distention (HP:0003270)3.52154342
31Infertility (HP:0000789)3.45147253
32Conjugated hyperbilirubinemia (HP:0002908)3.44228107
33Reticulocytosis (HP:0001923)3.41062254
34Chronic sinusitis (HP:0011109)3.32053354
35Onycholysis (HP:0001806)3.27831227
36Congenital sensorineural hearing impairment (HP:0008527)3.27187241
37Ventricular fibrillation (HP:0001663)3.26812123
38Fragile nails (HP:0001808)3.24956065
39Plantar hyperkeratosis (HP:0007556)3.18808471
40Hyperinsulinemic hypoglycemia (HP:0000825)3.18018029
41Male infertility (HP:0003251)3.17925602
42Woolly hair (HP:0002224)3.16597949
43Poikilocytosis (HP:0004447)3.15555595
44Milia (HP:0001056)3.14641892
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.14092204
46Chronic diarrhea (HP:0002028)3.13547593
47Ketoacidosis (HP:0001993)3.12546808
48Recurrent sinusitis (HP:0011108)3.11226750
49Symptomatic seizures (HP:0011145)3.06674624
50Abnormality of chloride homeostasis (HP:0011422)3.01593327
51Autoimmune thrombocytopenia (HP:0001973)2.98030565
52Palpitations (HP:0001962)2.94022848
53Flat acetabular roof (HP:0003180)2.93194255
54Fat malabsorption (HP:0002630)2.86302959
55Fragile skin (HP:0001030)2.85948830
56Abnormality of glycine metabolism (HP:0010895)2.83532357
57Abnormality of serine family amino acid metabolism (HP:0010894)2.83532357
58Abnormal pancreas size (HP:0012094)2.74211383
59Gastrointestinal dysmotility (HP:0002579)2.73969881
60Abnormality of small intestinal villus morphology (HP:0011472)2.70621755
61Villous atrophy (HP:0011473)2.70621755
62Cupped ribs (HP:0000887)2.69106474
63Amelogenesis imperfecta (HP:0000705)2.68275676
64Atrophic scars (HP:0001075)2.66343013
65Abnormal tarsal ossification (HP:0008369)2.65969888
66Hypoplasia of the uterus (HP:0000013)2.65196269
67Dehydration (HP:0001944)2.61313107
68Syncope (HP:0001279)2.60752398
69Metabolic alkalosis (HP:0200114)2.59644896
70Intrahepatic cholestasis (HP:0001406)2.59120940
71Lip pit (HP:0100267)2.58953465
72Hyperparathyroidism (HP:0000843)2.58705543
73Hyperaldosteronism (HP:0000859)2.57964556
74Recurrent otitis media (HP:0000403)2.57384904
75Rectal prolapse (HP:0002035)2.54830342
76Abnormality of the vitamin B12 metabolism (HP:0004341)2.54055497
77Seborrheic dermatitis (HP:0001051)2.53217938
78Ankyloglossia (HP:0010296)2.52988430
79Acanthocytosis (HP:0001927)2.50818745
80Autoimmune hemolytic anemia (HP:0001890)2.48798691
81Poikiloderma (HP:0001029)2.48088092
82Prolonged neonatal jaundice (HP:0006579)2.43028784
83Insulin-resistant diabetes mellitus (HP:0000831)2.42111789
84Micronodular cirrhosis (HP:0001413)2.39608649
85Periodontitis (HP:0000704)2.39413145
86Tubulointerstitial nephritis (HP:0001970)2.38459237
87Hypobetalipoproteinemia (HP:0003563)2.36997230
88Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.35909054
89Abnormality of vitamin B metabolism (HP:0004340)2.33842726
90Mildly elevated creatine phosphokinase (HP:0008180)2.32423884
91Cheilitis (HP:0100825)2.32348456
92Cone-rod dystrophy (HP:0000548)2.30431003
93Annular pancreas (HP:0001734)2.30102805
94Hyperammonemia (HP:0001987)2.29495237
95Steatorrhea (HP:0002570)2.25233617
96Premature loss of primary teeth (HP:0006323)2.24229677
97Symphalangism affecting the phalanges of the hand (HP:0009773)2.22028242
98Limb-girdle muscle atrophy (HP:0003797)2.19684401
99Abnormality of the 1st metacarpal (HP:0010009)2.17134294
100Hyperkalemia (HP:0002153)2.16757822
101Chronic hepatic failure (HP:0100626)2.15059446
102Ventricular tachycardia (HP:0004756)2.15050132
103Glycosuria (HP:0003076)2.14272862
104Abnormality of urine glucose concentration (HP:0011016)2.14272862
105Palmoplantar hyperkeratosis (HP:0000972)2.13566218
106Ureteral stenosis (HP:0000071)2.12561681
107Ventricular arrhythmia (HP:0004308)2.12481708
108Renal salt wasting (HP:0000127)2.08342743
109Hypoplasia of dental enamel (HP:0006297)2.07625155
110Abnormality of reticulocytes (HP:0004312)2.07104046
111Hyperphosphatemia (HP:0002905)2.06996985
112Abnormal glucose tolerance (HP:0001952)2.05568690
113Chronic otitis media (HP:0000389)2.05468081
114Pigmentary retinal degeneration (HP:0001146)2.05401564
115Petechiae (HP:0000967)2.04637377
116Inflammation of the large intestine (HP:0002037)2.03762109
117Curly hair (HP:0002212)2.03681901
118Pili torti (HP:0003777)2.03460651
119Abnormality of renin-angiotensin system (HP:0000847)2.02735038
120Aortic aneurysm (HP:0004942)2.02500206
121Pancreatic fibrosis (HP:0100732)2.01846733
122Osteomalacia (HP:0002749)2.00194864
123Gout (HP:0001997)1.98588320
124Increased purine levels (HP:0004368)1.98451275
125Hyperuricemia (HP:0002149)1.98451275
126Proximal tubulopathy (HP:0000114)1.98388627
127Myopathic facies (HP:0002058)1.97715973
128Abnormality of vitamin metabolism (HP:0100508)1.97360820
129Gingivitis (HP:0000230)1.96724285
130Recurrent bronchitis (HP:0002837)1.96683300
131Palmar hyperkeratosis (HP:0010765)1.96543886
132Occipital encephalocele (HP:0002085)1.95901221
133Facial diplegia (HP:0001349)1.92089599
134Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91570580
135Hyperglycemia (HP:0003074)1.91507151
136Ureteral obstruction (HP:0006000)1.91149206
137Widely patent fontanelles and sutures (HP:0004492)1.90922488
138Abnormality of the aortic arch (HP:0012303)1.90781085
139Adrenal overactivity (HP:0002717)1.87883779
140Abnormality of the distal phalanx of the thumb (HP:0009617)1.87820493
141Abnormal foot bone ossification (HP:0010675)1.86500236
142Gastrointestinal inflammation (HP:0004386)1.85761568
143Mesangial abnormality (HP:0001966)1.85387056
144Ridged nail (HP:0001807)1.83926948
145Abnormality of transition element cation homeostasis (HP:0011030)1.82894625
146Increased mean platelet volume (HP:0011877)1.82646383
147Gastrointestinal stroma tumor (HP:0100723)1.82315694
148Hypotension (HP:0002615)1.81779916
149Exocrine pancreatic insufficiency (HP:0001738)1.81720558
150Severe combined immunodeficiency (HP:0004430)1.81548650
151Vascular calcification (HP:0004934)1.80414331
152Alkalosis (HP:0001948)1.80215390
153Nephronophthisis (HP:0000090)1.74740643
154True hermaphroditism (HP:0010459)1.73949266
155Abnormality of the pancreatic islet cells (HP:0006476)1.71560445
156Abnormality of endocrine pancreas physiology (HP:0012093)1.71560445
157Abnormality of midbrain morphology (HP:0002418)1.71252534
158Molar tooth sign on MRI (HP:0002419)1.71252534
159Atelectasis (HP:0100750)1.70987785
160Tubular atrophy (HP:0000092)1.69119487
161Cystic liver disease (HP:0006706)1.69118268
162Abnormality of macular pigmentation (HP:0008002)1.68749702
163Abnormality of magnesium homeostasis (HP:0004921)1.68079081
164Hyponatremia (HP:0002902)1.67543678
165Hypokalemia (HP:0002900)1.66688252
166Abnormal biliary tract morphology (HP:0012440)1.66208194
167Median cleft lip (HP:0000161)1.64958332
168Increased circulating renin level (HP:0000848)1.62865878
169Subcapsular cataract (HP:0000523)1.62401503
170Pancreatic cysts (HP:0001737)1.61969666
171Posterior subcapsular cataract (HP:0007787)1.61650635
172Abnormality of calcium-phosphate metabolism (HP:0100530)1.61290692
173Lower limb hyperreflexia (HP:0002395)1.61254166
174Megaloblastic anemia (HP:0001889)1.60922794
175Abnormality of the renal medulla (HP:0100957)1.59792430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.72477345
2MST1R5.19667239
3LMTK24.83498052
4MAPK154.78203973
5FRK4.03102785
6ACVR1B3.99429973
7ERBB43.10623412
8EPHA23.00875021
9NME12.90015295
10MAP2K22.81745235
11STK242.67003462
12PRKG22.56386260
13PTK62.54901411
14MYLK2.49072900
15NEK62.39856581
16BRSK22.18425092
17RIPK12.17862489
18TESK12.06946147
19MAP3K22.03920255
20NUAK11.86576740
21GRK61.76144510
22EPHB21.74643239
23ERN11.71978671
24MET1.63027418
25AKT31.58842734
26STK391.57271962
27BMPR1B1.53927109
28PASK1.50609663
29EPHB11.50198787
30MAPKAPK31.42699024
31IRAK31.36580424
32INSRR1.30149140
33MAP2K61.23603085
34PTK21.22928739
35PIK3CA1.20725479
36STK101.18788426
37MAP3K121.18183871
38MAP3K141.18008404
39FER1.15248714
40ERBB21.11784101
41NLK1.11626433
42STK38L1.10440149
43FGFR31.09179088
44MAP3K101.08227181
45MAP2K11.03346555
46MAP3K111.02927165
47RIPK40.97660694
48PRKAA20.95608335
49PIK3CG0.94962488
50KSR20.93839457
51PRKCI0.93380590
52CDC42BPA0.91599574
53IRAK10.89375452
54OXSR10.86714750
55DDR20.86135009
56LIMK10.85429688
57LATS10.83471212
58MAP3K80.82098576
59BCR0.77544503
60CDK120.76450884
61LRRK20.75538289
62STK380.75341503
63PAK40.74973225
64BMX0.73822905
65TRPM70.73305008
66MAP3K30.73223396
67NTRK30.72412409
68PNCK0.70443067
69DMPK0.67893458
70STK30.67142921
71MELK0.65846077
72MATK0.63438377
73TBK10.60000733
74PKN20.57936258
75DYRK1B0.57382824
76HIPK20.56785581
77SGK20.56290578
78RPS6KB20.55245878
79MAP3K40.54087189
80MAP3K10.53739117
81ITK0.53640203
82CASK0.53573886
83CHUK0.53291616
84TNIK0.50869395
85YES10.49741570
86MAP4K10.49270711
87TYK20.48547770
88FGFR40.48152730
89CDK90.46633032
90CAMKK10.45692857
91PBK0.45681392
92SRC0.44559297
93MAPK110.43795665
94MAP3K130.43490862
95WNK40.43334785
96PRKCE0.42529923
97ROCK10.41553150
98MAP3K70.41135473
99CAMK2D0.40515218
100PIM20.40216754
101ROCK20.39990638
102EEF2K0.39911330
103FGFR20.38939865
104CAMK2G0.38853932
105PAK30.38691307
106IKBKE0.38568733
107TTN0.38519763
108TAOK10.37871533
109EGFR0.37584506
110CDK80.37099064
111PDK20.36720976
112MUSK0.36631336
113GRK10.35769916
114TTK0.35578678
115PRKCZ0.35357864
116TAOK30.35110649
117PDPK10.34932450
118PAK10.34863079
119CAMK2B0.34642003
120PRKCA0.34397096
121ERBB30.33833475
122MAP3K90.32883540
123STK160.32834067
124PRKAA10.32245927
125EIF2AK30.31858927
126PRKCD0.30937908
127PRKCQ0.30818701
128SGK30.30505452
129SGK2230.30373651
130SGK4940.30373651
131FYN0.30288371
132SCYL20.30276712
133IGF1R0.29977687
134PRKACA0.29742893
135AURKB0.29168955
136BMPR20.29030899
137MAP3K60.28348929
138JAK20.28117150
139PAK20.27443382
140CSK0.27154752
141CAMK2A0.26489812
142CSNK1A10.25402787
143EPHA30.25356448
144JAK10.23887559
145PRKACG0.23120509
146MAPKAPK20.23014330
147DAPK20.22313394
148PDK10.21354171

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.54480599
2Sulfur metabolism_Homo sapiens_hsa009203.91765812
3Mineral absorption_Homo sapiens_hsa049783.74399584
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.55253877
5Histidine metabolism_Homo sapiens_hsa003403.28363062
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.23740268
7Vitamin digestion and absorption_Homo sapiens_hsa049772.96141365
8Renin-angiotensin system_Homo sapiens_hsa046142.77562250
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.32480365
10Bile secretion_Homo sapiens_hsa049762.16709207
11Protein digestion and absorption_Homo sapiens_hsa049741.83546450
12Glutathione metabolism_Homo sapiens_hsa004801.82328730
13Thyroid hormone synthesis_Homo sapiens_hsa049181.78589034
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78298630
15Caffeine metabolism_Homo sapiens_hsa002321.70969369
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70339675
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.68067259
18Fructose and mannose metabolism_Homo sapiens_hsa000511.66479225
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.64615884
20Galactose metabolism_Homo sapiens_hsa000521.62763493
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58322501
22Gastric acid secretion_Homo sapiens_hsa049711.56574717
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52572840
24Glycerolipid metabolism_Homo sapiens_hsa005611.50673736
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49832293
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.49773121
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47566405
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45770236
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42492815
30Linoleic acid metabolism_Homo sapiens_hsa005911.35506719
31Tryptophan metabolism_Homo sapiens_hsa003801.30795354
32Insulin secretion_Homo sapiens_hsa049111.26504407
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26440484
34Fatty acid degradation_Homo sapiens_hsa000711.21622912
35Starch and sucrose metabolism_Homo sapiens_hsa005001.21260183
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19604511
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.17093079
38Ether lipid metabolism_Homo sapiens_hsa005651.17048457
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15948022
40Pancreatic secretion_Homo sapiens_hsa049721.13065259
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10676252
42Chemical carcinogenesis_Homo sapiens_hsa052041.09391074
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06238712
44Ovarian steroidogenesis_Homo sapiens_hsa049131.02822496
45Circadian rhythm_Homo sapiens_hsa047101.02590950
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.00302586
47Nitrogen metabolism_Homo sapiens_hsa009100.96827498
48PPAR signaling pathway_Homo sapiens_hsa033200.96305569
49Asthma_Homo sapiens_hsa053100.93739544
50Tight junction_Homo sapiens_hsa045300.92162571
51Arachidonic acid metabolism_Homo sapiens_hsa005900.90598484
52Pyruvate metabolism_Homo sapiens_hsa006200.86578090
53Peroxisome_Homo sapiens_hsa041460.84720177
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83824518
55Sphingolipid metabolism_Homo sapiens_hsa006000.83185632
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81840987
57Arginine and proline metabolism_Homo sapiens_hsa003300.77958709
58Arginine biosynthesis_Homo sapiens_hsa002200.77052693
59beta-Alanine metabolism_Homo sapiens_hsa004100.75721406
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75068343
61Folate biosynthesis_Homo sapiens_hsa007900.74978962
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74207863
63Type II diabetes mellitus_Homo sapiens_hsa049300.70361130
64Type I diabetes mellitus_Homo sapiens_hsa049400.70064800
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.67895614
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65569914
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.64753946
68Insulin resistance_Homo sapiens_hsa049310.62503882
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61754233
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60071550
71ABC transporters_Homo sapiens_hsa020100.59832952
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58695404
73Pentose phosphate pathway_Homo sapiens_hsa000300.55565683
74Carbon metabolism_Homo sapiens_hsa012000.55545814
75Salivary secretion_Homo sapiens_hsa049700.55377977
76Salmonella infection_Homo sapiens_hsa051320.55256963
77Phenylalanine metabolism_Homo sapiens_hsa003600.53165984
78Collecting duct acid secretion_Homo sapiens_hsa049660.51735284
79Regulation of autophagy_Homo sapiens_hsa041400.50444554
80Bladder cancer_Homo sapiens_hsa052190.45565531
81Fatty acid biosynthesis_Homo sapiens_hsa000610.44845541
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.44798263
83Retinol metabolism_Homo sapiens_hsa008300.44723183
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44146068
85Primary immunodeficiency_Homo sapiens_hsa053400.42489282
86Amphetamine addiction_Homo sapiens_hsa050310.41864954
87Vibrio cholerae infection_Homo sapiens_hsa051100.41801165
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41426480
89Serotonergic synapse_Homo sapiens_hsa047260.41401724
90Protein export_Homo sapiens_hsa030600.38796148
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37975962
92Adherens junction_Homo sapiens_hsa045200.37875302
93Hepatitis C_Homo sapiens_hsa051600.36988045
94Fatty acid elongation_Homo sapiens_hsa000620.36854382
95Cocaine addiction_Homo sapiens_hsa050300.36441214
96Thyroid cancer_Homo sapiens_hsa052160.33883025
97African trypanosomiasis_Homo sapiens_hsa051430.32317991
98VEGF signaling pathway_Homo sapiens_hsa043700.31365393
99Butanoate metabolism_Homo sapiens_hsa006500.31273347
100Toxoplasmosis_Homo sapiens_hsa051450.31171315
101GnRH signaling pathway_Homo sapiens_hsa049120.29069380
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.27144653
103Metabolic pathways_Homo sapiens_hsa011000.27135907
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26345596
105Dorso-ventral axis formation_Homo sapiens_hsa043200.26076838
106Huntingtons disease_Homo sapiens_hsa050160.26046565
107Taste transduction_Homo sapiens_hsa047420.25644117
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24293837
109Propanoate metabolism_Homo sapiens_hsa006400.24018463
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23734398
111TGF-beta signaling pathway_Homo sapiens_hsa043500.22388047
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.21683619
113Leishmaniasis_Homo sapiens_hsa051400.21328786
114Glucagon signaling pathway_Homo sapiens_hsa049220.20171409
115Fatty acid metabolism_Homo sapiens_hsa012120.19845767
116Oxidative phosphorylation_Homo sapiens_hsa001900.18611228
117AMPK signaling pathway_Homo sapiens_hsa041520.17511274
118Inositol phosphate metabolism_Homo sapiens_hsa005620.17102684
119Amoebiasis_Homo sapiens_hsa051460.17047699
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16949279
121Pertussis_Homo sapiens_hsa051330.16320058
122Renin secretion_Homo sapiens_hsa049240.15735958
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15607992
124Choline metabolism in cancer_Homo sapiens_hsa052310.15332213
125Tyrosine metabolism_Homo sapiens_hsa003500.14944627
126Other glycan degradation_Homo sapiens_hsa005110.14614256
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13474606
128Hematopoietic cell lineage_Homo sapiens_hsa046400.10455009
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10291672
130Legionellosis_Homo sapiens_hsa051340.09783379
131Influenza A_Homo sapiens_hsa051640.08844306

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »