CAPN14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transepithelial transport (GO:0070633)8.91753462
2establishment of skin barrier (GO:0061436)7.25460180
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.94435427
4regulation of water loss via skin (GO:0033561)6.20755977
5regulation of ruffle assembly (GO:1900027)6.15935773
6epidermis development (GO:0008544)6.00623716
7keratinocyte development (GO:0003334)5.50403925
8ectoderm development (GO:0007398)5.48697846
9apical protein localization (GO:0045176)5.46404808
10keratinocyte proliferation (GO:0043616)5.30918160
11hair follicle morphogenesis (GO:0031069)5.28879493
12establishment of tissue polarity (GO:0007164)5.22231611
13establishment of planar polarity (GO:0001736)5.22231611
14multicellular organismal water homeostasis (GO:0050891)5.10860390
15eyelid development in camera-type eye (GO:0061029)4.85468900
16citrulline biosynthetic process (GO:0019240)4.83684889
17hair cell differentiation (GO:0035315)4.81688284
18response to phenylpropanoid (GO:0080184)4.68592229
19asymmetric protein localization (GO:0008105)4.25755507
20planar cell polarity pathway involved in neural tube closure (GO:0090179)4.14212562
21water homeostasis (GO:0030104)4.09445353
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.88548809
23negative regulation of cell fate specification (GO:0009996)3.87608826
24sperm capacitation (GO:0048240)3.77463545
25positive regulation of epidermis development (GO:0045684)3.70298599
26O-glycan processing (GO:0016266)3.59139403
27positive regulation of epidermal cell differentiation (GO:0045606)3.58235453
28negative regulation of stress fiber assembly (GO:0051497)3.51304848
29epithelial cell differentiation (GO:0030855)3.50961210
30peptidyl-arginine modification (GO:0018195)3.49378384
31hemidesmosome assembly (GO:0031581)3.48708035
32ventricular cardiac muscle cell action potential (GO:0086005)3.48012906
33membrane raft organization (GO:0031579)3.47328344
34multicellular organism reproduction (GO:0032504)3.47236524
35fucose catabolic process (GO:0019317)3.40997451
36L-fucose metabolic process (GO:0042354)3.40997451
37L-fucose catabolic process (GO:0042355)3.40997451
38leukocyte aggregation (GO:0070486)3.36291441
39sphingomyelin metabolic process (GO:0006684)3.32877616
40regulation of Cdc42 GTPase activity (GO:0043088)3.30430662
41polarized epithelial cell differentiation (GO:0030859)3.29382271
42negative regulation of cell-substrate adhesion (GO:0010812)3.27998018
43detection of bacterium (GO:0016045)3.27470100
44negative regulation of keratinocyte proliferation (GO:0010839)3.25852711
45gap junction assembly (GO:0016264)3.20875848
46regulation of B cell receptor signaling pathway (GO:0050855)3.20587609
47localization within membrane (GO:0051668)3.18907008
48negative regulation of interleukin-8 production (GO:0032717)3.11124908
49protein-chromophore linkage (GO:0018298)3.10379923
50citrulline metabolic process (GO:0000052)3.04977341
51hair cycle (GO:0042633)3.03945771
52molting cycle (GO:0042303)3.03945771
53thyroid hormone generation (GO:0006590)2.98675773
54primary alcohol catabolic process (GO:0034310)2.96070836
55regulation of keratinocyte differentiation (GO:0045616)2.94612228
56detection of other organism (GO:0098543)2.91704926
57epithelium development (GO:0060429)2.91351833
58negative regulation of actin filament bundle assembly (GO:0032232)2.85661380
59negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82784110
60striated muscle atrophy (GO:0014891)2.82085649
61activation of Rac GTPase activity (GO:0032863)2.79937620
62histone H3-K36 demethylation (GO:0070544)2.75267928
63hypotonic response (GO:0006971)2.74211471
64superoxide anion generation (GO:0042554)2.71869225
65positive regulation of vesicle fusion (GO:0031340)2.71220957
66negative regulation of acute inflammatory response (GO:0002674)2.68930378
67fucosylation (GO:0036065)2.68596450
68molting cycle process (GO:0022404)2.67805652
69hair cycle process (GO:0022405)2.67805652
70thyroid hormone metabolic process (GO:0042403)2.66941630
71epithelial cell-cell adhesion (GO:0090136)2.66725875
72regulation of clathrin-mediated endocytosis (GO:2000369)2.64713750
73regulation of pH (GO:0006885)2.63439170
74cellular response to retinoic acid (GO:0071300)2.59158813
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.58303555
76intermediate filament organization (GO:0045109)2.57918412
77face development (GO:0060324)2.57080384
78embryonic camera-type eye development (GO:0031076)2.56597210
79regulation of keratinocyte proliferation (GO:0010837)2.56481780
80leukocyte migration involved in inflammatory response (GO:0002523)2.55816519
81sequestering of metal ion (GO:0051238)2.55496009
82regulation of epidermis development (GO:0045682)2.54345922
83skeletal muscle adaptation (GO:0043501)2.53874112
84leukotriene metabolic process (GO:0006691)2.52438337
85tachykinin receptor signaling pathway (GO:0007217)2.51727527
86negative regulation of bone mineralization (GO:0030502)2.50008725
87positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.46451252
88leukotriene biosynthetic process (GO:0019370)2.46144537
89defense response to fungus (GO:0050832)2.45799280
90membrane tubulation (GO:0097320)2.43213350
91cellular response to fluid shear stress (GO:0071498)2.42509814
92negative regulation of interferon-gamma production (GO:0032689)2.41888913
93wound healing (GO:0042060)2.41300290
94lipoxygenase pathway (GO:0019372)2.37029040
95pericardium development (GO:0060039)2.36375300
96peptide cross-linking (GO:0018149)17.5493554
97keratinization (GO:0031424)16.5778270
98keratinocyte differentiation (GO:0030216)13.1830748
99desmosome organization (GO:0002934)11.4842635
100epidermal cell differentiation (GO:0009913)10.6481041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.57595889
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.36695155
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.37642619
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.32438933
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.30875426
6VDR_22108803_ChIP-Seq_LS180_Human3.01419008
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96209240
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.88092955
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.75357191
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.52931940
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.52931940
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.24898196
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09086286
14KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.93785843
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.89479720
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82580524
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73452665
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69933753
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69726502
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67352068
21* TP63_22573176_ChIP-Seq_HFKS_Human1.66710848
22GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.66319040
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.65692794
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63807825
25SOX2_20726797_ChIP-Seq_SW620_Human1.59920383
26RXR_22108803_ChIP-Seq_LS180_Human1.55597672
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.55094943
28KLF5_25053715_ChIP-Seq_YYC3_Human1.54612458
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.52463047
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.50459747
31ERG_20517297_ChIP-Seq_VCAP_Human1.49032203
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46534709
33TP63_23658742_ChIP-Seq_EP156T_Human1.45851840
34RACK7_27058665_Chip-Seq_MCF-7_Human1.45109561
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.43680115
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43653639
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.41675712
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41020358
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.40757650
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38080683
41CTCF_27219007_Chip-Seq_Bcells_Human1.36858983
42GATA6_21074721_ChIP-Seq_CACO-2_Human1.35169143
43DROSHA_22980978_ChIP-Seq_HELA_Human1.32079378
44RBPJ_21746931_ChIP-Seq_IB4_Human1.30997519
45CEBPB_22108803_ChIP-Seq_LS180_Human1.30824005
46GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.30309871
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29949936
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25988402
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24709806
50* GATA3_24758297_ChIP-Seq_MCF-7_Human1.22780672
51CJUN_26792858_Chip-Seq_BT549_Human1.18425866
52AR_21572438_ChIP-Seq_LNCaP_Human1.17452230
53SMC4_20622854_ChIP-Seq_HELA_Human1.13302672
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12268032
55BCAT_22108803_ChIP-Seq_LS180_Human1.11775056
56SA1_27219007_Chip-Seq_Bcells_Human1.11020396
57* SMAD3_21741376_ChIP-Seq_HESCs_Human1.09963228
58BCOR_27268052_Chip-Seq_Bcells_Human1.09795047
59GATA4_25053715_ChIP-Seq_YYC3_Human1.09107484
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07117992
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06973015
62ETV1_20927104_ChIP-Seq_GIST48_Human1.04825971
63AHR_22903824_ChIP-Seq_MCF-7_Human1.04659398
64P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04109455
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03975773
66TP53_18474530_ChIP-ChIP_U2OS_Human1.01257005
67NFYB_21822215_ChIP-Seq_K562_Human1.00904075
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00003641
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99004549
70AR_25329375_ChIP-Seq_VCAP_Human0.98429946
71HNFA_21074721_ChIP-Seq_CACO-2_Human0.96710367
72ATF3_27146783_Chip-Seq_COLON_Human0.95266550
73CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94502406
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94496901
75EGR1_19032775_ChIP-ChIP_M12_Human0.93739892
76SA1_27219007_Chip-Seq_ERYTHROID_Human0.88214813
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88123035
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87614882
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87406920
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.86985374
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86822366
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86398710
83GATA6_25053715_ChIP-Seq_YYC3_Human0.85685033
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85216567
85TAF15_26573619_Chip-Seq_HEK293_Human0.85154742
86NANOG_20526341_ChIP-Seq_ESCs_Human0.84615772
87PHF8_20622853_ChIP-Seq_HELA_Human0.84458389
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84411456
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84028149
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84028149
91TBL1_22424771_ChIP-Seq_293T_Human0.83676110
92CTCF_20526341_ChIP-Seq_ESCs_Human0.83248693
93HTT_18923047_ChIP-ChIP_STHdh_Human0.83201998
94* SMAD4_21741376_ChIP-Seq_HESCs_Human0.80829466
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80268679
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79630882
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79630773
98E2F1_20622854_ChIP-Seq_HELA_Human0.79605145
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.78196450
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77575758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.71775305
2MP0004043_abnormal_pH_regulation7.23760455
3MP0002796_impaired_skin_barrier6.40053694
4MP0000467_abnormal_esophagus_morphology4.56038347
5MP0005501_abnormal_skin_physiology3.51059140
6MP0000762_abnormal_tongue_morphology3.42715267
7MP0000579_abnormal_nail_morphology3.41045827
8MP0010678_abnormal_skin_adnexa2.96733814
9MP0005275_abnormal_skin_tensile2.94561824
10MP0002095_abnormal_skin_pigmentation2.70745316
11MP0003453_abnormal_keratinocyte_physiol2.61368310
12MP0000371_diluted_coat_color2.41560552
13MP0001216_abnormal_epidermal_layer2.36597964
14MP0000465_gastrointestinal_hemorrhage2.28354794
15MP0004264_abnormal_extraembryonic_tissu2.16051079
16MP0002098_abnormal_vibrissa_morphology2.00829836
17MP0009053_abnormal_anal_canal1.99174894
18MP0005451_abnormal_body_composition1.93738362
19MP0000383_abnormal_hair_follicle1.82350010
20MP0004885_abnormal_endolymph1.76799535
21MP0002638_abnormal_pupillary_reflex1.74302435
22MP0003878_abnormal_ear_physiology1.72095624
23MP0005377_hearing/vestibular/ear_phenot1.72095624
24MP0010771_integument_phenotype1.69934505
25MP0001851_eye_inflammation1.62904434
26MP0004185_abnormal_adipocyte_glucose1.56085730
27MP0000470_abnormal_stomach_morphology1.53215533
28MP0003566_abnormal_cell_adhesion1.52803486
29MP0000377_abnormal_hair_follicle1.40543107
30MP0004084_abnormal_cardiac_muscle1.38264366
31MP0000427_abnormal_hair_cycle1.38237465
32MP0002234_abnormal_pharynx_morphology1.33167986
33MP0000566_synostosis1.24553214
34MP0003763_abnormal_thymus_physiology1.22973295
35MP0001243_abnormal_dermal_layer1.21066359
36MP0002060_abnormal_skin_morphology1.17520099
37MP0002837_dystrophic_cardiac_calcinosis1.15311926
38MP0002075_abnormal_coat/hair_pigmentati1.09504946
39MP0000367_abnormal_coat/_hair1.06740441
40MP0003183_abnormal_peptide_metabolism1.04526769
41MP0005666_abnormal_adipose_tissue1.03129417
42MP0010352_gastrointestinal_tract_polyps0.99738906
43MP0001765_abnormal_ion_homeostasis0.96645721
44MP0009931_abnormal_skin_appearance0.94060550
45MP0004036_abnormal_muscle_relaxation0.91976808
46MP0001873_stomach_inflammation0.91551148
47MP0004381_abnormal_hair_follicle0.90795498
48MP0003828_pulmonary_edema0.88319376
49MP0008789_abnormal_olfactory_epithelium0.87551558
50MP0003950_abnormal_plasma_membrane0.76472787
51MP0008875_abnormal_xenobiotic_pharmacok0.74708484
52MP0001485_abnormal_pinna_reflex0.74332295
53MP0010030_abnormal_orbit_morphology0.74326868
54MP0005023_abnormal_wound_healing0.74289430
55MP0001186_pigmentation_phenotype0.74074894
56MP0004947_skin_inflammation0.73558875
57MP0000678_abnormal_parathyroid_gland0.73458425
58MP0004215_abnormal_myocardial_fiber0.73050867
59MP0000049_abnormal_middle_ear0.69903441
60MP0002249_abnormal_larynx_morphology0.68130680
61MP0000685_abnormal_immune_system0.65616104
62MP0003638_abnormal_response/metabolism_0.61005345
63MP0000613_abnormal_salivary_gland0.60720959
64MP0003705_abnormal_hypodermis_morpholog0.60165998
65MP0002254_reproductive_system_inflammat0.59822971
66MP0005394_taste/olfaction_phenotype0.58394649
67MP0005499_abnormal_olfactory_system0.58394649
68MP0006138_congestive_heart_failure0.55467989
69MP0002009_preneoplasia0.54109202
70MP0003191_abnormal_cellular_cholesterol0.53332985
71MP0001784_abnormal_fluid_regulation0.52330868
72MP0005375_adipose_tissue_phenotype0.51180938
73MP0003806_abnormal_nucleotide_metabolis0.49868172
74MP0001191_abnormal_skin_condition0.49577850
75MP0005387_immune_system_phenotype0.47739120
76MP0001790_abnormal_immune_system0.47739120
77MP0005409_darkened_coat_color0.45558725
78MP0000372_irregular_coat_pigmentation0.45232496
79MP0004019_abnormal_vitamin_homeostasis0.42809174
80MP0008260_abnormal_autophagy0.42391391
81MP0008057_abnormal_DNA_replication0.40689101
82MP0001800_abnormal_humoral_immune0.40338255
83MP0001270_distended_abdomen0.39112127
84MP0002006_tumorigenesis0.38298148
85MP0002166_altered_tumor_susceptibility0.37831049
86MP0010386_abnormal_urinary_bladder0.37612997
87MP0001340_abnormal_eyelid_morphology0.36890267
88MP0003755_abnormal_palate_morphology0.36632401
89MP0008569_lethality_at_weaning0.35713459
90MP0005671_abnormal_response_to0.34306332
91MP0009780_abnormal_chondrocyte_physiolo0.34269460
92MP0002877_abnormal_melanocyte_morpholog0.33914619
93MP0002111_abnormal_tail_morphology0.32210957
94MP0008004_abnormal_stomach_pH0.31653015
95MP0005193_abnormal_anterior_eye0.30668348
96MP0001502_abnormal_circadian_rhythm0.30593716
97MP0005253_abnormal_eye_physiology0.29615277
98MP0002735_abnormal_chemical_nociception0.28969910
99MP0005330_cardiomyopathy0.28588184
100MP0010155_abnormal_intestine_physiology0.27477964

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.06890819
2Erythroderma (HP:0001019)6.77979004
3Lip pit (HP:0100267)6.48687835
4Palmoplantar hyperkeratosis (HP:0000972)6.35937168
5Palmar hyperkeratosis (HP:0010765)6.09745429
6Plantar hyperkeratosis (HP:0007556)5.54433638
7Congenital ichthyosiform erythroderma (HP:0007431)5.48045140
8Increased IgE level (HP:0003212)5.10462072
9Right ventricular cardiomyopathy (HP:0011663)5.09366190
10Hypotrichosis (HP:0001006)4.98959326
11Alopecia of scalp (HP:0002293)4.96038511
12Corneal erosion (HP:0200020)4.46747713
13Fragile nails (HP:0001808)4.39721108
14Abnormality of the salivary glands (HP:0010286)4.31894216
15Pustule (HP:0200039)4.09884063
16Erythema (HP:0010783)4.08571217
17Thick nail (HP:0001805)4.04475851
18Nail dystrophy (HP:0008404)3.91125299
19Abnormality of secondary sexual hair (HP:0009888)3.76754898
20Abnormality of the axillary hair (HP:0100134)3.76754898
21Sparse scalp hair (HP:0002209)3.75895986
22Onycholysis (HP:0001806)3.66572995
23Hyperactive renin-angiotensin system (HP:0000841)3.62469544
24Absent eyelashes (HP:0000561)3.51605665
25Ectropion (HP:0000656)3.37867639
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.27622304
27Popliteal pterygium (HP:0009756)3.23979935
28Woolly hair (HP:0002224)3.20953292
29Palmoplantar keratoderma (HP:0000982)3.03736924
30Hypohidrosis (HP:0000966)3.01237516
31Bilateral sensorineural hearing impairment (HP:0008619)2.93277328
32Autoamputation (HP:0001218)2.90729543
33Hyperkalemia (HP:0002153)2.90657926
34Absent hair (HP:0002298)2.84133040
35Hypoplastic labia majora (HP:0000059)2.80863376
36Villous atrophy (HP:0011473)2.72061094
37Abnormality of small intestinal villus morphology (HP:0011472)2.72061094
38Sparse eyelashes (HP:0000653)2.71172329
39Pili torti (HP:0003777)2.68311250
40Gangrene (HP:0100758)2.65514568
41Ridged nail (HP:0001807)2.61714693
42Brittle hair (HP:0002299)2.61128884
43Ventricular tachycardia (HP:0004756)2.53351082
44Dehydration (HP:0001944)2.53251308
45Abnormality of the labia majora (HP:0012881)2.52991882
46Furrowed tongue (HP:0000221)2.52885028
47Decreased circulating renin level (HP:0003351)2.51841901
48Oligodontia (HP:0000677)2.51109692
49Nasal polyposis (HP:0100582)2.47303925
50Urticaria (HP:0001025)2.46939425
51Chronic bronchitis (HP:0004469)2.44968067
52Milia (HP:0001056)2.44425825
53Acanthosis nigricans (HP:0000956)2.42718176
54Abnormal blistering of the skin (HP:0008066)2.39380762
55Distal lower limb muscle weakness (HP:0009053)2.35557644
56Abnormal hair laboratory examination (HP:0003328)2.35151831
57Blepharitis (HP:0000498)2.34205343
58Abnormality of the dental pulp (HP:0006479)2.24072386
59Multifactorial inheritance (HP:0001426)2.23495817
60Squamous cell carcinoma (HP:0002860)2.17406446
61Cystic hygroma (HP:0000476)2.08744385
62Amniotic constriction ring (HP:0009775)2.01680957
63Abnormality of placental membranes (HP:0011409)2.01680957
64B lymphocytopenia (HP:0010976)2.01077015
65Conical tooth (HP:0000698)2.00886370
66Malnutrition (HP:0004395)2.00070611
67Oral leukoplakia (HP:0002745)16.0592824
68Trismus (HP:0000211)1.99288335
69Abnormality of B cell number (HP:0010975)1.96905420
70Abnormality of the nasal mucosa (HP:0000433)1.96812299
71Pruritus (HP:0000989)1.95409763
72Parakeratosis (HP:0001036)1.91804442
73Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.91257529
74Renal salt wasting (HP:0000127)1.89830629
75Labial hypoplasia (HP:0000066)1.89647708
76Abnormality of chloride homeostasis (HP:0011422)1.88497496
77Skin pits (HP:0100276)1.87134351
78Curly hair (HP:0002212)1.81644399
79Hyperlipoproteinemia (HP:0010980)1.80314865
80Seborrheic dermatitis (HP:0001051)1.80048597
81Hyperaldosteronism (HP:0000859)1.79182096
82Verrucae (HP:0200043)1.79090354
83Papilloma (HP:0012740)1.79090354
84Elbow flexion contracture (HP:0002987)1.77829437
85Anhidrosis (HP:0000970)1.76833116
86Sudden death (HP:0001699)1.74451917
87Hyporeflexia of lower limbs (HP:0002600)1.72510982
88Split foot (HP:0001839)1.70783750
89Fine hair (HP:0002213)1.69659480
90Coarse hair (HP:0002208)1.69319662
91Hypergammaglobulinemia (HP:0010702)1.67661456
92Hypokalemic alkalosis (HP:0001949)1.66809533
93Lack of skin elasticity (HP:0100679)1.65404730
94Anonychia (HP:0001798)1.65346816
95Keratoconjunctivitis sicca (HP:0001097)1.65286621
96Hypoplastic female external genitalia (HP:0012815)1.65101788
97Dry skin (HP:0000958)1.62530128
98Sepsis (HP:0100806)1.61907056
99Skin ulcer (HP:0200042)1.60987501
100Skin rash (HP:0000988)1.60852286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.64534437
2EPHA24.48633120
3MAPKAPK34.15233753
4MAP3K33.77187799
5MAP3K23.00101155
6SIK12.99296131
7RIPK12.94734353
8ERBB32.86832032
9MAP3K62.80015303
10FER2.65849187
11EPHA32.55516129
12GRK62.46810500
13TRPM72.43599914
14MAP3K92.16763188
15MST1R2.09707664
16RPS6KB21.92336561
17MARK21.84648841
18FRK1.83536060
19TGFBR11.71993437
20NME11.54773526
21MAP3K71.44670323
22BLK1.43521040
23OBSCN1.18700635
24MET1.14851656
25BCR1.14756096
26ERN11.14555070
27SIK21.13699134
28JAK31.11360910
29PRKD21.07998871
30LRRK21.07464659
31FGFR30.99949875
32MAP2K60.99353469
33PRKD30.98257436
34CDK80.95440518
35CDC42BPA0.94651822
36ITK0.93801278
37MST40.90228098
38WNK10.88085984
39TBK10.86930284
40BTK0.85934001
41FGR0.84113599
42TEC0.80459604
43DMPK0.78041018
44LATS10.76230874
45IRAK10.75192081
46GRK10.74777129
47TAOK10.74332850
48IRAK20.74208196
49MUSK0.73945703
50MELK0.70794914
51STK240.69692978
52PIK3CG0.68238599
53MARK30.64346299
54PRKAA20.63898082
55MAP4K10.61023431
56DDR20.60338703
57PRKD10.58395553
58BMPR1B0.58248297
59MAP3K130.55074957
60MAPKAPK20.54952489
61IKBKB0.54947918
62RPS6KB10.52068052
63HCK0.51633546
64PTK60.51616055
65MAP3K110.49278637
66ZAP700.46439253
67MAP3K100.44136897
68NEK60.43378156
69TRIB30.42503452
70PRKCD0.42103419
71ADRBK10.42026509
72CSK0.41679963
73LMTK20.41634343
74IRAK30.41505929
75IGF1R0.38562092
76CDK90.38086456
77EGFR0.37817923
78PKN10.37682498
79MAP2K10.36830127
80IKBKE0.36137585
81MAP3K40.35725390
82PRKAA10.33152827
83MYLK0.32449049
84TXK0.32399821
85MAPK70.32136675
86WNK30.30803352
87ROCK10.30460625
88IRAK40.29751117
89PRKCH0.29337053
90PRKCQ0.28563194
91FYN0.27916267
92PBK0.27018512
93SRC0.26643128
94MAP4K20.24152387
95PRKG20.23388052
96CDK120.23114338
97STK30.22806221
98ABL10.22508537
99PRKCE0.22298805
100MAP2K20.22293714

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.52433902
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.55377786
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.25785174
4Primary immunodeficiency_Homo sapiens_hsa053402.23928258
5Phototransduction_Homo sapiens_hsa047442.11782193
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.07440068
7Sphingolipid metabolism_Homo sapiens_hsa006002.03891703
8Linoleic acid metabolism_Homo sapiens_hsa005911.99659506
9Ether lipid metabolism_Homo sapiens_hsa005651.81973033
10Arachidonic acid metabolism_Homo sapiens_hsa005901.76805685
11Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.73294563
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65384216
13Olfactory transduction_Homo sapiens_hsa047401.63362689
14Vascular smooth muscle contraction_Homo sapiens_hsa042701.62458653
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55064142
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.52975636
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50898982
18Renin secretion_Homo sapiens_hsa049241.49141369
19T cell receptor signaling pathway_Homo sapiens_hsa046601.48587054
20Amoebiasis_Homo sapiens_hsa051461.46929772
21GnRH signaling pathway_Homo sapiens_hsa049121.46640010
22Retinol metabolism_Homo sapiens_hsa008301.46232442
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43805096
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.42411988
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38485726
26Endocytosis_Homo sapiens_hsa041441.36736535
27Salivary secretion_Homo sapiens_hsa049701.32155358
28B cell receptor signaling pathway_Homo sapiens_hsa046621.31720990
29Circadian rhythm_Homo sapiens_hsa047101.28385556
30VEGF signaling pathway_Homo sapiens_hsa043701.26692527
31Histidine metabolism_Homo sapiens_hsa003401.26257695
32Pancreatic secretion_Homo sapiens_hsa049721.21418400
33Taste transduction_Homo sapiens_hsa047421.20820654
34Chemical carcinogenesis_Homo sapiens_hsa052041.19247560
35Acute myeloid leukemia_Homo sapiens_hsa052211.16772876
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16120121
37Pancreatic cancer_Homo sapiens_hsa052121.09411317
38p53 signaling pathway_Homo sapiens_hsa041151.08512516
39Phenylalanine metabolism_Homo sapiens_hsa003601.02690427
40Dorso-ventral axis formation_Homo sapiens_hsa043201.02588492
41Long-term potentiation_Homo sapiens_hsa047201.02000149
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01783433
43Calcium signaling pathway_Homo sapiens_hsa040201.00229144
44Ras signaling pathway_Homo sapiens_hsa040140.98727054
45Hematopoietic cell lineage_Homo sapiens_hsa046400.98126319
46Tyrosine metabolism_Homo sapiens_hsa003500.96283887
47Inositol phosphate metabolism_Homo sapiens_hsa005620.93623182
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89268764
49Notch signaling pathway_Homo sapiens_hsa043300.88845780
50Serotonergic synapse_Homo sapiens_hsa047260.88231032
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87261704
52Chronic myeloid leukemia_Homo sapiens_hsa052200.86461388
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86415106
54Choline metabolism in cancer_Homo sapiens_hsa052310.84864741
55Glioma_Homo sapiens_hsa052140.81500308
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80082828
57TNF signaling pathway_Homo sapiens_hsa046680.79114896
58Platelet activation_Homo sapiens_hsa046110.79081257
59Gastric acid secretion_Homo sapiens_hsa049710.77970343
60ErbB signaling pathway_Homo sapiens_hsa040120.77599042
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.76582875
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76109261
63Shigellosis_Homo sapiens_hsa051310.73350828
64Dilated cardiomyopathy_Homo sapiens_hsa054140.71950208
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.70817464
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70478006
67Adherens junction_Homo sapiens_hsa045200.68559964
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.68242228
69Melanogenesis_Homo sapiens_hsa049160.64943470
70Small cell lung cancer_Homo sapiens_hsa052220.64824085
71Ovarian steroidogenesis_Homo sapiens_hsa049130.64474956
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.63477334
73Oxytocin signaling pathway_Homo sapiens_hsa049210.63210175
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61458466
75Tight junction_Homo sapiens_hsa045300.60887582
76Non-small cell lung cancer_Homo sapiens_hsa052230.59303599
77Circadian entrainment_Homo sapiens_hsa047130.57881027
78Axon guidance_Homo sapiens_hsa043600.54500625
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53963774
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53848190
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.53802431
82Insulin signaling pathway_Homo sapiens_hsa049100.52684441
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50882677
84Renal cell carcinoma_Homo sapiens_hsa052110.50732419
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50160971
86Prolactin signaling pathway_Homo sapiens_hsa049170.49663476
87Glutamatergic synapse_Homo sapiens_hsa047240.49542935
88ABC transporters_Homo sapiens_hsa020100.49378383
89Tuberculosis_Homo sapiens_hsa051520.45527115
90Influenza A_Homo sapiens_hsa051640.44785937
91Glycerolipid metabolism_Homo sapiens_hsa005610.42053264
92Focal adhesion_Homo sapiens_hsa045100.41659770
93Insulin resistance_Homo sapiens_hsa049310.40874716
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.40777366
95Glutathione metabolism_Homo sapiens_hsa004800.40753329
96Hepatitis C_Homo sapiens_hsa051600.40450149
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38685285
98Chemokine signaling pathway_Homo sapiens_hsa040620.38426559
99Bladder cancer_Homo sapiens_hsa052190.38219076
100Salmonella infection_Homo sapiens_hsa051320.37356974

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