CAPN15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)5.08976708
2cytoskeletal anchoring at plasma membrane (GO:0007016)4.26272357
3locomotory exploration behavior (GO:0035641)3.97708990
4regulation of ARF protein signal transduction (GO:0032012)3.97673339
5synaptic vesicle maturation (GO:0016188)3.74783273
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.73367726
7regulation of NFAT protein import into nucleus (GO:0051532)3.69607573
8apoptotic process involved in morphogenesis (GO:0060561)3.69579984
9positive regulation of histone deacetylation (GO:0031065)3.63982930
10activation of Rac GTPase activity (GO:0032863)3.56740358
11regulation of cholesterol homeostasis (GO:2000188)3.54672281
12pre-miRNA processing (GO:0031054)3.51847432
13cellular potassium ion homeostasis (GO:0030007)3.48180441
14positive regulation of Cdc42 GTPase activity (GO:0043089)3.42939067
15regulation of clathrin-mediated endocytosis (GO:2000369)3.29605337
16regulation of ARF GTPase activity (GO:0032312)3.29603373
173-UTR-mediated mRNA stabilization (GO:0070935)3.27383009
18positive regulation of synapse maturation (GO:0090129)3.24007454
19negative regulation of cell size (GO:0045792)3.20995645
20antigen processing and presentation of endogenous antigen (GO:0019883)3.19310784
21NIK/NF-kappaB signaling (GO:0038061)3.16344940
22cerebellar Purkinje cell differentiation (GO:0021702)3.06978609
23layer formation in cerebral cortex (GO:0021819)3.06415189
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03000520
25negative regulation of viral release from host cell (GO:1902187)3.01308717
26epithelial cell differentiation involved in prostate gland development (GO:0060742)3.01115262
27response to peptidoglycan (GO:0032494)3.00129749
28establishment of nucleus localization (GO:0040023)2.97551891
29regulation of histone H3-K27 methylation (GO:0061085)2.97266655
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.95734360
31regulation of gamma-delta T cell differentiation (GO:0045586)2.94297841
32regulation of translational termination (GO:0006449)2.93397665
33regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93268970
34response to laminar fluid shear stress (GO:0034616)2.90829812
35peptidyl-lysine dimethylation (GO:0018027)2.88378129
36regulation of extracellular matrix disassembly (GO:0010715)2.85772436
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84957210
38regulation of glucose import in response to insulin stimulus (GO:2001273)2.84032504
39negative regulation of erythrocyte differentiation (GO:0045647)2.82843469
40response to pheromone (GO:0019236)2.82373783
41mannose metabolic process (GO:0006013)2.82036292
42positive regulation by symbiont of host defense response (GO:0052509)2.81894371
43modulation by symbiont of host defense response (GO:0052031)2.81894371
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81894371
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81894371
46positive regulation by organism of defense response of other organism involved in symbiotic interact2.81894371
47modulation by symbiont of host immune response (GO:0052553)2.81894371
48negative regulation of fatty acid transport (GO:2000192)2.81789336
49T cell selection (GO:0045058)2.81715904
50negative regulation of myotube differentiation (GO:0010832)2.79874331
51regulation of early endosome to late endosome transport (GO:2000641)2.79376499
52embryonic process involved in female pregnancy (GO:0060136)2.78040681
53protein localization to endosome (GO:0036010)2.78031614
54neuromuscular process controlling balance (GO:0050885)2.77973289
55intracellular estrogen receptor signaling pathway (GO:0030520)2.77886337
56response to muramyl dipeptide (GO:0032495)2.77701797
57activation of MAPKKK activity (GO:0000185)2.77501444
58regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76153717
59regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74984452
60modulation by symbiont of host cellular process (GO:0044068)2.72578002
61L-alpha-amino acid transmembrane transport (GO:1902475)2.72169902
62modulation by virus of host process (GO:0019054)2.70559719
63regulation of necroptotic process (GO:0060544)2.65663489
64glucocorticoid receptor signaling pathway (GO:0042921)2.64816579
65adherens junction assembly (GO:0034333)2.64293195
66proline biosynthetic process (GO:0006561)2.63177464
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63118054
68apoptotic cell clearance (GO:0043277)2.62866337
69regulation of integrin activation (GO:0033623)2.62362106
70activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62263365
71semaphorin-plexin signaling pathway (GO:0071526)2.62028611
72pinocytosis (GO:0006907)2.61235845
73regulation of gamma-delta T cell activation (GO:0046643)2.59705090
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.58871756
75cell communication by electrical coupling (GO:0010644)2.56887990
76negative regulation of nucleotide catabolic process (GO:0030812)2.56692468
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.55668926
78cell-substrate junction assembly (GO:0007044)2.54840880
79cerebellar Purkinje cell layer development (GO:0021680)2.54794078
80cytoplasmic mRNA processing body assembly (GO:0033962)2.53703543
81activation of JUN kinase activity (GO:0007257)2.53347496
82macrophage activation involved in immune response (GO:0002281)2.53321940
83RNA stabilization (GO:0043489)2.53026304
84mRNA stabilization (GO:0048255)2.53026304
85detection of bacterium (GO:0016045)2.52657192
86megakaryocyte development (GO:0035855)2.51939817
87positive regulation of gamma-delta T cell activation (GO:0046645)2.51533631
88regulation of translational fidelity (GO:0006450)2.50366330
89regulation of necrotic cell death (GO:0010939)2.50100317
90positive regulation of fibroblast migration (GO:0010763)2.50092889
91cellular sodium ion homeostasis (GO:0006883)2.49961482
92leukocyte aggregation (GO:0070486)2.49180480
93positive regulation of nuclease activity (GO:0032075)2.48999707
94positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48373129
95positive thymic T cell selection (GO:0045059)2.48149296
96gamma-aminobutyric acid transport (GO:0015812)2.47749419
97glucose 6-phosphate metabolic process (GO:0051156)2.47335795
98dicarboxylic acid biosynthetic process (GO:0043650)2.46808525
99natural killer cell differentiation (GO:0001779)2.45546363
100antigen processing and presentation via MHC class Ib (GO:0002475)2.44814857
101maternal placenta development (GO:0001893)2.44643425
102mitotic G1/S transition checkpoint (GO:0044819)2.44332365
103COPI coating of Golgi vesicle (GO:0048205)2.43299889
104Golgi transport vesicle coating (GO:0048200)2.43299889
105cell-substrate adherens junction assembly (GO:0007045)2.42499780
106focal adhesion assembly (GO:0048041)2.42499780
107regulation of synapse structural plasticity (GO:0051823)2.42497305
108germinal center formation (GO:0002467)2.41839047
109potassium ion import (GO:0010107)2.41819843
110macroautophagy (GO:0016236)2.41769063
111atrioventricular valve morphogenesis (GO:0003181)2.40691310
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40008351
113signal complex assembly (GO:0007172)2.39847641
114thymic T cell selection (GO:0045061)2.39691947
115pentose-phosphate shunt (GO:0006098)2.39490530
116stress fiber assembly (GO:0043149)2.39459923
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.38738416
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38429755
119positive regulation of protein deacetylation (GO:0090312)2.37707328
120detection of other organism (GO:0098543)2.37241612
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.37110629
122negative thymic T cell selection (GO:0045060)2.36241192
123establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35621581
124positive regulation of blood vessel endothelial cell migration (GO:0043536)2.35167019
125mitotic G1 DNA damage checkpoint (GO:0031571)2.34816891
126desmosome organization (GO:0002934)2.34207300
127cellular response to epidermal growth factor stimulus (GO:0071364)2.33995608
128regulation of fatty acid beta-oxidation (GO:0031998)2.33934738
129cellular response to virus (GO:0098586)2.33433564
130negative regulation of GTP catabolic process (GO:0033125)2.33431060
131negative regulation of GTPase activity (GO:0034260)2.33431060
132regulation of chromatin binding (GO:0035561)2.32897051
133positive regulation of gene expression, epigenetic (GO:0045815)2.32569393
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32542894
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.31746564
136stress granule assembly (GO:0034063)2.31325638
137receptor catabolic process (GO:0032801)2.30761929
138glycine transport (GO:0015816)2.30138502
139apoptotic process involved in development (GO:1902742)2.29138574
140negative regulation of necroptotic process (GO:0060546)2.28271081
141neurotransmitter secretion (GO:0007269)2.28263781
142positive T cell selection (GO:0043368)2.28126573
143histone H3-K36 demethylation (GO:0070544)2.28120428
144negative regulation of granulocyte differentiation (GO:0030853)2.27872090
145positive regulation of receptor recycling (GO:0001921)2.27216575
146regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25657819
147potassium ion homeostasis (GO:0055075)2.25624356
148trophectodermal cell differentiation (GO:0001829)2.24172999
149negative regulation of lipid transport (GO:0032369)2.23144000
150positive regulation of Rap GTPase activity (GO:0032854)2.22696769
151cell differentiation in hindbrain (GO:0021533)2.22265729
152regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21189272
153negative regulation of histone methylation (GO:0031061)2.20694198
154cerebellar granule cell differentiation (GO:0021707)2.20084314
155prepulse inhibition (GO:0060134)2.18159167
156glutamate secretion (GO:0014047)2.17541322
157regulation of nuclease activity (GO:0032069)2.17512542
158activation of protein kinase A activity (GO:0034199)2.15691224
159negative regulation of purine nucleotide catabolic process (GO:0033122)2.15546457
160chromatin silencing (GO:0006342)2.15149831
161membrane tubulation (GO:0097320)2.14675078
162negative regulation of protein oligomerization (GO:0032460)2.13660510
163alanine transport (GO:0032328)2.12705972
164positive regulation of triglyceride biosynthetic process (GO:0010867)2.11998853
165negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.11439596
166negative regulation of cell killing (GO:0031342)2.11439596
167regulation of polysaccharide biosynthetic process (GO:0032885)2.10956020
168antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.10550501
169antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.10550501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.44734594
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.32483097
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18517927
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.83600152
5KDM2B_26808549_Chip-Seq_DND41_Human2.80002315
6LXR_22292898_ChIP-Seq_THP-1_Human2.60835302
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.54254219
8TCF7_22412390_ChIP-Seq_EML_Mouse2.47241963
9KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43917411
10VDR_21846776_ChIP-Seq_THP-1_Human2.29063642
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27729684
12KDM2B_26808549_Chip-Seq_K562_Human2.24641419
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17892205
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15693440
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.14271015
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13400147
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.07222711
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04216496
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03956628
20KDM2B_26808549_Chip-Seq_JURKAT_Human1.99933647
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94748448
22RACK7_27058665_Chip-Seq_MCF-7_Human1.87486291
23EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86077645
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75862114
25GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75112045
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74817976
27E2F7_22180533_ChIP-Seq_HELA_Human1.70262364
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69750781
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66681611
30ZNF263_19887448_ChIP-Seq_K562_Human1.64698143
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.63962376
32P68_20966046_ChIP-Seq_HELA_Human1.63794911
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62161820
34DROSHA_22980978_ChIP-Seq_HELA_Human1.61589629
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61111695
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59289643
37UTX_26944678_Chip-Seq_JUKART_Human1.59234965
38CREB1_26743006_Chip-Seq_LNCaP_Human1.58221200
39MAF_26560356_Chip-Seq_TH1_Human1.57813236
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56128853
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55126224
42GATA1_19941826_ChIP-Seq_K562_Human1.54951912
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54752794
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53965871
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53186414
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.52872484
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51470620
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.47769245
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.46925957
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.44207442
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43962247
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42204630
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41760608
54SMC4_20622854_ChIP-Seq_HELA_Human1.41710715
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41481272
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39773888
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39115767
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38392070
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36852112
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35388890
61TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35199748
62NCOR1_26117541_ChIP-Seq_K562_Human1.34459065
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33862916
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32852674
65SCL_19346495_ChIP-Seq_HPC-7_Human1.32412277
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.31581845
67VDR_24763502_ChIP-Seq_THP-1_Human1.31499349
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31266107
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30828738
70SPI1_23127762_ChIP-Seq_K562_Human1.30633072
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.29578378
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.27444343
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26082160
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25580263
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24730547
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.24517921
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24412321
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.22628085
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21114040
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21102408
81ATF3_27146783_Chip-Seq_COLON_Human1.20928937
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.20413287
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19807076
84BCOR_27268052_Chip-Seq_Bcells_Human1.19611616
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19019420
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16256863
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15460370
88TP53_22127205_ChIP-Seq_IMR90_Human1.14629586
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14346559
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14224383
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12740052
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12422993
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10634065
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08602773
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07774918
96TP63_22573176_ChIP-Seq_HFKS_Human1.07419172
97MAF_26560356_Chip-Seq_TH2_Human1.07078656
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06787729
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.06690553
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06267419
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05834843
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05755316
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05479493
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05288865
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.05017377
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04742408
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03832331
108BCL6_27268052_Chip-Seq_Bcells_Human1.02933774
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02280845
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01786965
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01514693
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01356871
113PHF8_20622854_ChIP-Seq_HELA_Human0.99286182
114CTCF_27219007_Chip-Seq_Bcells_Human0.99161487
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99146401
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98637478
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98545777
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.98147374
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97638615
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.97474624
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96638776
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.96403722
123MYB_26560356_Chip-Seq_TH1_Human0.96287950
124ETS1_21867929_ChIP-Seq_TH2_Mouse0.96024383
125CLOCK_20551151_ChIP-Seq_293T_Human0.95820194
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.93932868
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.93869921
128GATA2_19941826_ChIP-Seq_K562_Human0.92569110
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91846807
130E2F1_20622854_ChIP-Seq_HELA_Human0.91286980
131FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91022042
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90586123
133FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89773007
134GATA1_22025678_ChIP-Seq_K562_Human0.88909490
135CIITA_25753668_ChIP-Seq_RAJI_Human0.88454078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.56820475
2MP0003705_abnormal_hypodermis_morpholog4.29887946
3MP0008961_abnormal_basal_metabolism3.47192576
4MP0010234_abnormal_vibrissa_follicle3.00138367
5MP0005451_abnormal_body_composition2.95452683
6MP0005076_abnormal_cell_differentiation2.81735375
7MP0003436_decreased_susceptibility_to2.65615162
8MP0003303_peritoneal_inflammation2.52571896
9MP0010352_gastrointestinal_tract_polyps2.43942791
10MP0003300_gastrointestinal_ulcer2.22463003
11MP0009840_abnormal_foam_cell2.16721037
12MP0009278_abnormal_bone_marrow2.15911042
13MP0003329_amyloid_beta_deposits2.13419506
14MP0009333_abnormal_splenocyte_physiolog2.11539427
15MP0000678_abnormal_parathyroid_gland2.08961845
16MP0008260_abnormal_autophagy2.07633171
17MP0003172_abnormal_lysosome_physiology2.04842529
18MP0003283_abnormal_digestive_organ1.85569154
19MP0004858_abnormal_nervous_system1.81939692
20MP0002877_abnormal_melanocyte_morpholog1.81177791
21MP0000569_abnormal_digit_pigmentation1.80935012
22MP0008569_lethality_at_weaning1.77560084
23MP0002909_abnormal_adrenal_gland1.73292738
24MP0000604_amyloidosis1.67407456
25MP0003635_abnormal_synaptic_transmissio1.67124321
26MP0000858_altered_metastatic_potential1.65739444
27MP0005083_abnormal_biliary_tract1.64525451
28MP0002089_abnormal_postnatal_growth/wei1.64039685
29MP0005409_darkened_coat_color1.63698672
30MP0002249_abnormal_larynx_morphology1.60306189
31MP0005360_urolithiasis1.58689074
32MP0010155_abnormal_intestine_physiology1.57577704
33MP0001835_abnormal_antigen_presentation1.53368516
34MP0000490_abnormal_crypts_of1.50805240
35MP0001849_ear_inflammation1.49509126
36MP0004947_skin_inflammation1.47049287
37MP0005025_abnormal_response_to1.45891345
38MP0004510_myositis1.41979702
39MP0005397_hematopoietic_system_phenotyp1.40540124
40MP0001545_abnormal_hematopoietic_system1.40540124
41MP0005000_abnormal_immune_tolerance1.39821585
42MP0008770_decreased_survivor_rate1.34511265
43MP0003656_abnormal_erythrocyte_physiolo1.34019314
44MP0005387_immune_system_phenotype1.33466691
45MP0001790_abnormal_immune_system1.33466691
46MP0001800_abnormal_humoral_immune1.33290611
47MP0002796_impaired_skin_barrier1.32391237
48MP0000685_abnormal_immune_system1.31386149
49MP0002419_abnormal_innate_immunity1.30359468
50MP0003252_abnormal_bile_duct1.29924607
51MP0001348_abnormal_lacrimal_gland1.26718112
52MP0003566_abnormal_cell_adhesion1.26134283
53MP0002420_abnormal_adaptive_immunity1.25891842
54MP0001819_abnormal_immune_cell1.25883692
55MP0009046_muscle_twitch1.24702753
56MP0004381_abnormal_hair_follicle1.21886337
57MP0005670_abnormal_white_adipose1.21165292
58MP0000003_abnormal_adipose_tissue1.20268413
59MP0002723_abnormal_immune_serum1.20033663
60MP0003191_abnormal_cellular_cholesterol1.19858428
61MP0003866_abnormal_defecation1.19672479
62MP0002452_abnormal_antigen_presenting1.17045839
63MP0002998_abnormal_bone_remodeling1.16152892
64MP0002396_abnormal_hematopoietic_system1.14724275
65MP0002139_abnormal_hepatobiliary_system1.11917051
66MP0005671_abnormal_response_to1.11599739
67MP0000716_abnormal_immune_system1.11070479
68MP0004233_abnormal_muscle_weight1.11046870
69MP0003045_fibrosis1.10298627
70MP0004197_abnormal_fetal_growth/weight/1.09829574
71MP0004264_abnormal_extraembryonic_tissu1.09592712
72MP0000537_abnormal_urethra_morphology1.09107812
73MP0004185_abnormal_adipocyte_glucose1.08857990
74MP0003279_aneurysm1.07633965
75MP0005375_adipose_tissue_phenotype1.07462267
76MP0001533_abnormal_skeleton_physiology1.06914894
77MP0010329_abnormal_lipoprotein_level1.06818046
78MP0002429_abnormal_blood_cell1.05530965
79MP0002405_respiratory_system_inflammati1.05240493
80MP0004811_abnormal_neuron_physiology1.03696441
81MP0009672_abnormal_birth_weight1.01670460
82MP0003075_altered_response_to1.01439801
83MP0004808_abnormal_hematopoietic_stem0.99838213
84MP0005310_abnormal_salivary_gland0.97321423
85MP0005365_abnormal_bile_salt0.96966160
86MP0002063_abnormal_learning/memory/cond0.96651636
87MP0003115_abnormal_respiratory_system0.96334963
88MP0010307_abnormal_tumor_latency0.95989716
89MP0000371_diluted_coat_color0.95114808
90MP0000477_abnormal_intestine_morphology0.95106092
91MP0003453_abnormal_keratinocyte_physiol0.95090417
92MP0000609_abnormal_liver_physiology0.93901069
93MP0002234_abnormal_pharynx_morphology0.93479436
94MP0002064_seizures0.93187045
95MP0009931_abnormal_skin_appearance0.93037818
96MP0002086_abnormal_extraembryonic_tissu0.92708597
97MP0009780_abnormal_chondrocyte_physiolo0.92688146
98MP0000747_muscle_weakness0.91538599
99MP0003091_abnormal_cell_migration0.90969822
100MP0005501_abnormal_skin_physiology0.90867054
101MP0001730_embryonic_growth_arrest0.90447755
102MP0004885_abnormal_endolymph0.89745913
103MP0001216_abnormal_epidermal_layer0.89501747
104MP0006082_CNS_inflammation0.89231691
105MP0005621_abnormal_cell_physiology0.88727858
106MP0001666_abnormal_nutrient_absorption0.88552085
107MP0002653_abnormal_ependyma_morphology0.87612662
108MP0002060_abnormal_skin_morphology0.87408882
109MP0001845_abnormal_inflammatory_respons0.86853677
110MP0002166_altered_tumor_susceptibility0.85703102
111MP0002933_joint_inflammation0.85052606
112MP0003111_abnormal_nucleus_morphology0.84826535
113MP0000703_abnormal_thymus_morphology0.84530756
114MP0000689_abnormal_spleen_morphology0.82242340
115MP0005058_abnormal_lysosome_morphology0.81629764
116MP0003183_abnormal_peptide_metabolism0.81084086
117MP0005666_abnormal_adipose_tissue0.80938430
118MP0008874_decreased_physiological_sensi0.80881807
119MP0000733_abnormal_muscle_development0.80772527
120MP0002084_abnormal_developmental_patter0.80738437
121MP0005464_abnormal_platelet_physiology0.80023591
122MP0003119_abnormal_digestive_system0.79040863
123MP0002254_reproductive_system_inflammat0.78952227
124MP0000767_abnormal_smooth_muscle0.78778305
125MP0001663_abnormal_digestive_system0.78673529
126MP0000467_abnormal_esophagus_morphology0.78276775
127MP0002088_abnormal_embryonic_growth/wei0.78044960
128MP0009785_altered_susceptibility_to0.77577267
129MP0003448_altered_tumor_morphology0.77366299
130MP0001873_stomach_inflammation0.77154100
131MP0010630_abnormal_cardiac_muscle0.77008846
132MP0002148_abnormal_hypersensitivity_rea0.76528136
133MP0002925_abnormal_cardiovascular_devel0.76384271
134MP0003984_embryonic_growth_retardation0.75797524
135MP0005023_abnormal_wound_healing0.75636797
136MP0002398_abnormal_bone_marrow0.74740183
137MP0002970_abnormal_white_adipose0.73544224
138MP0001672_abnormal_embryogenesis/_devel0.73289197
139MP0005380_embryogenesis_phenotype0.73289197
140MP0002269_muscular_atrophy0.73053502
141MP0000955_abnormal_spinal_cord0.72780535
142MP0005187_abnormal_penis_morphology0.72637199
143MP0000681_abnormal_thyroid_gland0.72329430
144MP0003633_abnormal_nervous_system0.72201519
145MP0000534_abnormal_ureter_morphology0.70403068
146MP0008872_abnormal_physiological_respon0.70114849
147MP0002722_abnormal_immune_system0.69553011
148MP0003763_abnormal_thymus_physiology0.68528209
149MP0000350_abnormal_cell_proliferation0.68413293
150MP0009745_abnormal_behavioral_response0.67751358
151MP0009703_decreased_birth_body0.67104251
152MP0002080_prenatal_lethality0.66830627
153MP0000579_abnormal_nail_morphology0.66036671

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.87316545
2Abnormality of the lower motor neuron (HP:0002366)3.59276022
3Insomnia (HP:0100785)3.40166514
4Broad face (HP:0000283)3.37998429
5Cerebral aneurysm (HP:0004944)3.27696044
6Eczematoid dermatitis (HP:0000976)3.23809583
7Dysmetric saccades (HP:0000641)3.17735447
8Obstructive sleep apnea (HP:0002870)3.00302485
9Hemiplegia (HP:0002301)2.97059626
10Upper limb amyotrophy (HP:0009129)2.94667371
11Distal upper limb amyotrophy (HP:0007149)2.94667371
12Neoplasm of the heart (HP:0100544)2.86191894
13Distal lower limb amyotrophy (HP:0008944)2.85795820
14Hand muscle atrophy (HP:0009130)2.85011408
15Thin bony cortex (HP:0002753)2.79927867
16Elfin facies (HP:0004428)2.72461823
17Visual hallucinations (HP:0002367)2.72052924
18Macroorchidism (HP:0000053)2.64915627
19Renovascular hypertension (HP:0100817)2.61535685
20Pointed chin (HP:0000307)2.61318770
21Hemorrhage of the eye (HP:0011885)2.61094342
22Reticulocytosis (HP:0001923)2.59031767
23Colitis (HP:0002583)2.58046159
24Annular pancreas (HP:0001734)2.53314218
25Stridor (HP:0010307)2.50617999
26Cellulitis (HP:0100658)2.49411165
27Shallow orbits (HP:0000586)2.41784615
28Abnormality of the fingertips (HP:0001211)2.39577174
29Heterotopia (HP:0002282)2.38437002
30Turricephaly (HP:0000262)2.34751692
31Flat acetabular roof (HP:0003180)2.33947365
32Overriding aorta (HP:0002623)2.30149031
33Increased connective tissue (HP:0009025)2.28680657
34Gastrointestinal inflammation (HP:0004386)2.27483849
35Recurrent bacterial skin infections (HP:0005406)2.24227401
36Impaired smooth pursuit (HP:0007772)2.22300676
37Renal duplication (HP:0000075)2.21985715
38J-shaped sella turcica (HP:0002680)2.21714255
39Malnutrition (HP:0004395)2.18037697
40Recurrent abscess formation (HP:0002722)2.17655729
41Aneurysm (HP:0002617)2.13424301
42Achilles tendon contracture (HP:0001771)2.13238864
43Increased cerebral lipofuscin (HP:0011813)2.12734295
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.12411700
45Ependymoma (HP:0002888)2.09642279
46Abnormality of macrophages (HP:0004311)2.08968688
47Long toe (HP:0010511)2.08104744
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.07607258
49Pustule (HP:0200039)2.07372472
50Abnormality of the Achilles tendon (HP:0005109)2.07049091
51Action tremor (HP:0002345)2.06708592
52Easy fatigability (HP:0003388)2.05560027
53Ureteral stenosis (HP:0000071)2.01712858
54Ulnar bowing (HP:0003031)2.01190573
55Poikilocytosis (HP:0004447)2.01108156
56Gingivitis (HP:0000230)2.01085282
57Genetic anticipation (HP:0003743)2.00339812
58Supranuclear gaze palsy (HP:0000605)2.00102913
59Abnormality of ocular smooth pursuit (HP:0000617)1.99693718
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.99359601
61Tetraplegia (HP:0002445)1.96742472
62Inflammation of the large intestine (HP:0002037)1.95980475
63Recurrent viral infections (HP:0004429)1.95901828
64Dysostosis multiplex (HP:0000943)1.95794566
65Abnormal social behavior (HP:0012433)1.95631317
66Impaired social interactions (HP:0000735)1.95631317
67Emphysema (HP:0002097)1.93821826
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92758301
69Short 4th metacarpal (HP:0010044)1.92758301
70Chronic obstructive pulmonary disease (HP:0006510)1.92234401
71Obstructive lung disease (HP:0006536)1.92234401
72Hypertriglyceridemia (HP:0002155)1.91855656
73Narrow palate (HP:0000189)1.91643074
74Fragile skin (HP:0001030)1.90387257
75Gastrointestinal dysmotility (HP:0002579)1.89776459
76Pseudobulbar signs (HP:0002200)1.88401998
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88190327
78Thoracic kyphosis (HP:0002942)1.87840761
79Increased IgE level (HP:0003212)1.87231529
80Mitral valve prolapse (HP:0001634)1.87117178
81Flat cornea (HP:0007720)1.87087491
82Focal seizures (HP:0007359)1.86481160
83Polycythemia (HP:0001901)1.84508234
84Aortic aneurysm (HP:0004942)1.84028652
85Seborrheic dermatitis (HP:0001051)1.83769775
86Amyotrophic lateral sclerosis (HP:0007354)1.83415963
87Ankyloglossia (HP:0010296)1.83291543
88Protrusio acetabuli (HP:0003179)1.83232176
89Status epilepticus (HP:0002133)1.82760725
90Bowel diverticulosis (HP:0005222)1.81486645
91Abnormality of the astrocytes (HP:0100707)1.81056075
92Astrocytoma (HP:0009592)1.81056075
93Ureteral obstruction (HP:0006000)1.79832713
94Broad palm (HP:0001169)1.79670370
95Trigonocephaly (HP:0000243)1.79481109
96Vertebral compression fractures (HP:0002953)1.79180235
97Urethral obstruction (HP:0000796)1.78927735
98Segmental peripheral demyelination/remyelination (HP:0003481)1.78281603
99Abnormality of the distal phalanges of the toes (HP:0010182)1.78229822
100Hypertensive crisis (HP:0100735)1.77786715
101Gastrointestinal infarctions (HP:0005244)1.77076460
102Increased serum ferritin (HP:0003281)1.76350855
103Sparse lateral eyebrow (HP:0005338)1.76177144
104Selective tooth agenesis (HP:0001592)1.75473276
105Autoimmune thrombocytopenia (HP:0001973)1.74990459
106Cervical subluxation (HP:0003308)1.74596823
107Asymmetry of the thorax (HP:0001555)1.74587388
108Mitral regurgitation (HP:0001653)1.74071165
109Abdominal distention (HP:0003270)1.73798107
110Distal lower limb muscle weakness (HP:0009053)1.73765563
111Dislocated radial head (HP:0003083)1.73658006
112Lymphangioma (HP:0100764)1.73462753
113Intention tremor (HP:0002080)1.73423995
114Vertebral arch anomaly (HP:0008438)1.72533310
115Myopathic facies (HP:0002058)1.72165190
116Rectal prolapse (HP:0002035)1.72029077
117Slow saccadic eye movements (HP:0000514)1.71791955
118Increased density of long bones (HP:0006392)1.70656360
119Postural instability (HP:0002172)1.70476066
120Disproportionate tall stature (HP:0001519)1.68938133
121Meningitis (HP:0001287)1.67762583
122Long palpebral fissure (HP:0000637)1.66149908
123Recurrent fungal infections (HP:0002841)1.66113260
124Increased nuchal translucency (HP:0010880)1.65508011
125Trismus (HP:0000211)1.65066964
126Broad distal phalanx of finger (HP:0009836)1.64832731
127Urinary urgency (HP:0000012)1.64458080
128Dilatation of the ascending aorta (HP:0005111)1.64324073
129Abnormality of the radial head (HP:0003995)1.64151952
130Abnormality of oral frenula (HP:0000190)1.64093901
131Germ cell neoplasia (HP:0100728)1.63990098
132Mildly elevated creatine phosphokinase (HP:0008180)1.63338407
133Metaphyseal cupping (HP:0003021)1.63312320
134Premature skin wrinkling (HP:0100678)1.63122524
135Bladder diverticulum (HP:0000015)1.62691417
136Obsessive-compulsive behavior (HP:0000722)1.62359345
137Absent frontal sinuses (HP:0002688)1.61958821
138Axonal loss (HP:0003447)1.61405777
139Anal stenosis (HP:0002025)1.61059105
140Bone pain (HP:0002653)1.60911006
141Mucopolysacchariduria (HP:0008155)1.60113679
142Urinary glycosaminoglycan excretion (HP:0003541)1.60113679
143Radial bowing (HP:0002986)1.59334673
144Premature rupture of membranes (HP:0001788)1.59299977
145Sacral dimple (HP:0000960)1.59211177
146Blue sclerae (HP:0000592)1.59157211
147Skin tags (HP:0010609)1.58782809
148Spinal cord lesions (HP:0100561)1.58770833
149Syringomyelia (HP:0003396)1.58770833
150Bowing of the arm (HP:0006488)1.58491661
151Bowed forearm bones (HP:0003956)1.58491661
152Truncus arteriosus (HP:0001660)1.58411518
153Viral hepatitis (HP:0006562)1.56338098
154Gastrointestinal stroma tumor (HP:0100723)1.56160427
155Short phalanx of the thumb (HP:0009660)1.55854485
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.55661600
157Milia (HP:0001056)1.55545049
158Diplopia (HP:0000651)1.55530001
159Abnormality of binocular vision (HP:0011514)1.55530001
160Dysdiadochokinesis (HP:0002075)1.53575723
161Depression (HP:0000716)1.52996498
162Ventricular fibrillation (HP:0001663)1.52383774
163Progressive cerebellar ataxia (HP:0002073)1.51753888
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51184443
165Deep venous thrombosis (HP:0002625)1.51108695
166Long eyelashes (HP:0000527)1.50352870
167Fibroma (HP:0010614)1.50033224
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.49916559
169Ankle clonus (HP:0011448)1.49219874
170Broad metatarsal (HP:0001783)1.49074612
171Abnormality of the 4th metacarpal (HP:0010012)1.48794358
172Arnold-Chiari malformation (HP:0002308)1.48768865
173Lower limb amyotrophy (HP:0007210)1.48711675
174Myokymia (HP:0002411)1.48685140
175Abnormality of the thoracic spine (HP:0100711)1.48089417
176Hallux valgus (HP:0001822)1.47858055
177Polygenic inheritance (HP:0010982)1.47640683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.71760782
2PRPF4B3.53458004
3TRIB33.49260190
4EEF2K3.44568992
5MAP3K103.37196492
6IRAK33.10617150
7ERN12.97000489
8CDK122.73402864
9PKN22.65803046
10TAOK12.55789185
11RIPK12.48397343
12MAP4K12.36710174
13ICK2.08805341
14MST1R1.94958210
15MAP3K91.91825546
16SIK11.89835286
17EPHA21.84538331
18SIK21.83233123
19PTK61.82344858
20NME21.72835840
21ALK1.72510416
22TYRO31.64474626
23PRKD31.63288604
24MAP3K71.60054240
25PDGFRA1.55556009
26CAMKK11.53760926
27PAK61.48212841
28IRAK41.44829335
29CAMK1G1.44829186
30BMX1.39039478
31DAPK21.37139548
32MTOR1.25575407
33GRK61.22882160
34MARK21.21085658
35STK381.20976923
36MAP3K31.20822977
37KSR21.19964949
38TTN1.18129755
39STK101.16768408
40PRKCH1.09169022
41CAMK1D1.02995561
42MAP3K141.02836231
43CDC42BPA1.01779276
44NTRK21.01666794
45IRAK21.01609990
46LRRK21.00750654
47PTK21.00488956
48FGFR41.00305275
49MAP3K130.92582819
50TBK10.91349241
51LATS20.91320150
52EPHB10.87520533
53NEK20.87247526
54RPS6KC10.86900350
55RPS6KL10.86900350
56RET0.84623443
57DDR20.83653811
58PRKD20.83460065
59FGFR10.80743799
60BTK0.76875888
61SCYL20.76628545
62BRD40.74975672
63STK110.74210765
64PAK20.73627122
65NTRK30.73319644
66BLK0.73257510
67LMTK20.72119266
68MAP3K110.70652936
69TNK20.70214520
70KDR0.69028372
71NTRK10.68646962
72SIK30.67257584
73RPS6KA60.66682997
74MAP2K20.66261998
75PDGFRB0.66036850
76RPS6KB20.64742511
77FGFR20.63814280
78CDK60.63133106
79PRKG20.61853310
80JAK10.61770819
81MAP3K80.61227514
82RPS6KA20.60925801
83CAMK40.60640703
84CDK40.60356612
85JAK20.60087771
86HIPK20.59966049
87FGFR30.59907160
88SGK30.59375218
89DYRK1B0.59057264
90PAK40.58954935
91AKT30.57260301
92DMPK0.56955973
93PDK10.56904688
94MAP3K10.56876806
95MINK10.56284267
96TYK20.55849453
97TESK20.55550694
98DAPK10.54539173
99CDK70.54169849
100MAPK120.54012663
101MAP2K30.52723978
102MAP3K60.52677848
103MAPK110.52376735
104TAOK30.51466060
105MAP3K20.50847452
106HCK0.50576514
107ZAP700.47053989
108MET0.46973571
109JAK30.46830541
110TAOK20.45478282
111RPS6KA10.45276193
112ILK0.45004265
113TESK10.44543896
114MAP2K60.43719100
115PRKD10.43656561
116PRKCI0.43652255
117CHUK0.43470776
118RIPK40.42767833
119CDK50.42544111
120CAMK10.42541365
121PDPK10.41701381
122FYN0.41697072
123ITK0.41358795
124IRAK10.40722689
125KSR10.40600927
126ERBB20.39998726
127MELK0.39929254
128MAPKAPK20.39905214
129CSF1R0.39492997
130UHMK10.38828256
131IKBKE0.38175542
132IKBKB0.37910116
133RPS6KA30.37844487
134CSK0.36376069
135MAPK80.36121713
136FES0.35753769
137NEK10.35612520
138CDK90.35441795

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.85034816
2Other glycan degradation_Homo sapiens_hsa005112.73169313
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73684175
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71853075
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71157105
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61598680
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59212598
8Type II diabetes mellitus_Homo sapiens_hsa049301.58978589
9mTOR signaling pathway_Homo sapiens_hsa041501.58148336
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54167161
11Lysine degradation_Homo sapiens_hsa003101.50343756
12Fructose and mannose metabolism_Homo sapiens_hsa000511.46915968
13Chronic myeloid leukemia_Homo sapiens_hsa052201.46218481
14Leishmaniasis_Homo sapiens_hsa051401.42783499
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37497783
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.36096652
17Long-term potentiation_Homo sapiens_hsa047201.32376635
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31642045
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30259967
20Sulfur relay system_Homo sapiens_hsa041221.29003721
21Bile secretion_Homo sapiens_hsa049761.27565711
22TNF signaling pathway_Homo sapiens_hsa046681.26328375
23Gastric acid secretion_Homo sapiens_hsa049711.25894132
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24441568
25Non-small cell lung cancer_Homo sapiens_hsa052231.22641561
26Toxoplasmosis_Homo sapiens_hsa051451.20231209
27Hepatitis C_Homo sapiens_hsa051601.20225510
28Acute myeloid leukemia_Homo sapiens_hsa052211.17818213
29B cell receptor signaling pathway_Homo sapiens_hsa046621.15971868
30Hepatitis B_Homo sapiens_hsa051611.15663596
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15480784
32Pentose phosphate pathway_Homo sapiens_hsa000301.14763043
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.13594085
34Salivary secretion_Homo sapiens_hsa049701.13508976
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.13471059
36Influenza A_Homo sapiens_hsa051641.12914711
37Glioma_Homo sapiens_hsa052141.12314788
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11672717
39Notch signaling pathway_Homo sapiens_hsa043301.11449208
40Estrogen signaling pathway_Homo sapiens_hsa049151.10127980
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10022412
42Arginine biosynthesis_Homo sapiens_hsa002201.06608206
43Apoptosis_Homo sapiens_hsa042101.04708980
44Thyroid cancer_Homo sapiens_hsa052161.04216533
45Dorso-ventral axis formation_Homo sapiens_hsa043201.03997176
46Synaptic vesicle cycle_Homo sapiens_hsa047211.03994658
47Insulin resistance_Homo sapiens_hsa049311.03882820
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03286756
49VEGF signaling pathway_Homo sapiens_hsa043701.03194342
50Glutamatergic synapse_Homo sapiens_hsa047241.03061208
51Circadian entrainment_Homo sapiens_hsa047130.99490471
52Herpes simplex infection_Homo sapiens_hsa051680.99064261
53Galactose metabolism_Homo sapiens_hsa000520.98865753
54Measles_Homo sapiens_hsa051620.98314382
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97623924
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96818468
57HTLV-I infection_Homo sapiens_hsa051660.96310613
58Tuberculosis_Homo sapiens_hsa051520.94239172
59Prion diseases_Homo sapiens_hsa050200.93272694
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91413670
61GnRH signaling pathway_Homo sapiens_hsa049120.91354207
62Oxytocin signaling pathway_Homo sapiens_hsa049210.91167150
63Viral carcinogenesis_Homo sapiens_hsa052030.90844231
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.90595256
65Prolactin signaling pathway_Homo sapiens_hsa049170.90416657
66Insulin secretion_Homo sapiens_hsa049110.89084449
67Proteoglycans in cancer_Homo sapiens_hsa052050.89068158
68GABAergic synapse_Homo sapiens_hsa047270.87473436
69Endometrial cancer_Homo sapiens_hsa052130.87293743
70Olfactory transduction_Homo sapiens_hsa047400.87215062
71Inositol phosphate metabolism_Homo sapiens_hsa005620.86709508
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.86541790
73Primary immunodeficiency_Homo sapiens_hsa053400.86181417
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85960459
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85022007
76Prostate cancer_Homo sapiens_hsa052150.84672733
77Graft-versus-host disease_Homo sapiens_hsa053320.83507471
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83492473
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.81199863
80Pancreatic cancer_Homo sapiens_hsa052120.78637993
81Endocytosis_Homo sapiens_hsa041440.78278210
82ErbB signaling pathway_Homo sapiens_hsa040120.78256443
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.77985849
84T cell receptor signaling pathway_Homo sapiens_hsa046600.76121894
85Viral myocarditis_Homo sapiens_hsa054160.75926114
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74778474
87Long-term depression_Homo sapiens_hsa047300.74739425
88AMPK signaling pathway_Homo sapiens_hsa041520.74521636
89Cholinergic synapse_Homo sapiens_hsa047250.74321074
90Platelet activation_Homo sapiens_hsa046110.74237061
91Gap junction_Homo sapiens_hsa045400.73547561
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72608808
93Insulin signaling pathway_Homo sapiens_hsa049100.72466274
94HIF-1 signaling pathway_Homo sapiens_hsa040660.71978056
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.71552479
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71439336
97Allograft rejection_Homo sapiens_hsa053300.71237327
98Morphine addiction_Homo sapiens_hsa050320.71206776
99Shigellosis_Homo sapiens_hsa051310.71015661
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69968381
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69843039
102ABC transporters_Homo sapiens_hsa020100.68552991
103cAMP signaling pathway_Homo sapiens_hsa040240.68139092
104Epstein-Barr virus infection_Homo sapiens_hsa051690.67232424
105Renal cell carcinoma_Homo sapiens_hsa052110.67230293
106Osteoclast differentiation_Homo sapiens_hsa043800.67033035
107MAPK signaling pathway_Homo sapiens_hsa040100.66200382
108Thyroid hormone synthesis_Homo sapiens_hsa049180.65521795
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64646421
110Glucagon signaling pathway_Homo sapiens_hsa049220.64581067
111Dopaminergic synapse_Homo sapiens_hsa047280.64331928
112Choline metabolism in cancer_Homo sapiens_hsa052310.64006819
113Renin secretion_Homo sapiens_hsa049240.63931027
114Bladder cancer_Homo sapiens_hsa052190.63680972
115Colorectal cancer_Homo sapiens_hsa052100.63359755
116Amphetamine addiction_Homo sapiens_hsa050310.62881299
117Salmonella infection_Homo sapiens_hsa051320.62181295
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61825980
119Cocaine addiction_Homo sapiens_hsa050300.61780942
120Autoimmune thyroid disease_Homo sapiens_hsa053200.61758664
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61499917
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60952129
123Chemokine signaling pathway_Homo sapiens_hsa040620.60708992
124Lysosome_Homo sapiens_hsa041420.60450962
125Rap1 signaling pathway_Homo sapiens_hsa040150.59918549
126Nicotine addiction_Homo sapiens_hsa050330.59380942
127Adherens junction_Homo sapiens_hsa045200.58860255
128Malaria_Homo sapiens_hsa051440.58525538
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.57493452
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57348387
131Biosynthesis of amino acids_Homo sapiens_hsa012300.57332758
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57071087
133Antigen processing and presentation_Homo sapiens_hsa046120.56517740
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.56502165
135Staphylococcus aureus infection_Homo sapiens_hsa051500.56481069
136Pertussis_Homo sapiens_hsa051330.56128551
137MicroRNAs in cancer_Homo sapiens_hsa052060.55939862
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55936282
139Small cell lung cancer_Homo sapiens_hsa052220.54772157
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.54270340
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.53671845
142Focal adhesion_Homo sapiens_hsa045100.53418644
143Amoebiasis_Homo sapiens_hsa051460.52308744
144Hippo signaling pathway_Homo sapiens_hsa043900.52304479
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50643924
146Pancreatic secretion_Homo sapiens_hsa049720.50124413
147FoxO signaling pathway_Homo sapiens_hsa040680.49730662

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