CAPN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)5.64838772
2ethanol oxidation (GO:0006069)5.19159966
3cellular glucuronidation (GO:0052695)5.02229659
4angiotensin maturation (GO:0002003)4.83943484
5uronic acid metabolic process (GO:0006063)4.80363294
6glucuronate metabolic process (GO:0019585)4.80363294
7exogenous drug catabolic process (GO:0042738)4.80196430
8regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.76942716
9intestinal absorption (GO:0050892)4.68469496
10drug catabolic process (GO:0042737)4.63220635
11central nervous system myelination (GO:0022010)4.44836973
12axon ensheathment in central nervous system (GO:0032291)4.44836973
13regulation of guanylate cyclase activity (GO:0031282)4.42275089
14ethanol metabolic process (GO:0006067)4.41444070
15drug metabolic process (GO:0017144)4.41270329
16renal system process involved in regulation of blood volume (GO:0001977)4.32612755
17urea metabolic process (GO:0019627)4.30962081
18fat-soluble vitamin biosynthetic process (GO:0042362)4.27136664
19peptidyl-tyrosine autophosphorylation (GO:0038083)4.21585491
20synaptic vesicle maturation (GO:0016188)4.16012627
21urea cycle (GO:0000050)4.10164927
22cytoskeletal anchoring at plasma membrane (GO:0007016)4.09626740
23bile acid and bile salt transport (GO:0015721)4.05237581
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03729781
25detection of temperature stimulus involved in sensory perception (GO:0050961)3.90188006
26detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.90188006
27nitrogen cycle metabolic process (GO:0071941)3.86998221
28axon ensheathment (GO:0008366)3.86107934
29ensheathment of neurons (GO:0007272)3.86107934
30neuron cell-cell adhesion (GO:0007158)3.79658406
31nerve growth factor signaling pathway (GO:0038180)3.78511270
32myelination (GO:0042552)3.77152179
33NADH metabolic process (GO:0006734)3.76976812
34flavonoid metabolic process (GO:0009812)3.74901393
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.74572139
36positive regulation of pseudopodium assembly (GO:0031274)3.73266610
37locomotory exploration behavior (GO:0035641)3.70394372
38hormone catabolic process (GO:0042447)3.69913810
39maintenance of gastrointestinal epithelium (GO:0030277)3.67265231
40detection of temperature stimulus (GO:0016048)3.63334756
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58710464
42primary alcohol catabolic process (GO:0034310)3.50393277
43negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.49733986
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.46117611
45renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.41148861
46regulation of systemic arterial blood pressure by hormone (GO:0001990)3.41036755
47regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.41036755
48endocrine process (GO:0050886)3.41036755
49negative regulation of microtubule polymerization (GO:0031115)3.40171326
50cell migration in hindbrain (GO:0021535)3.35722228
51long-chain fatty acid biosynthetic process (GO:0042759)3.35330807
52omega-hydroxylase P450 pathway (GO:0097267)3.35098010
53regulation of synaptic vesicle exocytosis (GO:2000300)3.34208871
54receptor guanylyl cyclase signaling pathway (GO:0007168)3.32240628
55glutamate secretion (GO:0014047)3.29717290
56bile acid metabolic process (GO:0008206)3.28068907
57regulation of pseudopodium assembly (GO:0031272)3.27786287
58synaptic vesicle exocytosis (GO:0016079)3.26167424
59L-serine transport (GO:0015825)3.24530772
60regulation of bile acid biosynthetic process (GO:0070857)3.24087893
61actin filament depolymerization (GO:0030042)3.21994948
62calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.20009937
63arginine metabolic process (GO:0006525)3.19033393
64transmission of nerve impulse (GO:0019226)3.18633463
65regulation of cholesterol homeostasis (GO:2000188)3.14831442
66glomerular filtration (GO:0003094)3.13812437
67negative regulation of axonogenesis (GO:0050771)3.13719426
68negative regulation of neurotransmitter secretion (GO:0046929)3.13632179
69positive regulation of respiratory burst (GO:0060267)3.13502557
70renal filtration (GO:0097205)3.13273919
71sodium ion homeostasis (GO:0055078)3.13233612
72vitamin transmembrane transport (GO:0035461)3.12541096
73positive regulation of guanylate cyclase activity (GO:0031284)3.12390885
74regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12215174
75oligosaccharide biosynthetic process (GO:0009312)3.10150948
76O-glycan processing (GO:0016266)3.09488734
77response to nerve growth factor (GO:1990089)3.08372502
78cellular response to nerve growth factor stimulus (GO:1990090)3.08372502
79negative regulation of neurotransmitter transport (GO:0051589)3.08359258
80diacylglycerol metabolic process (GO:0046339)3.07366515
81regulation of systemic arterial blood pressure (GO:0003073)3.05921991
82lipoprotein transport (GO:0042953)3.04226278
83neuronal action potential propagation (GO:0019227)3.03208072
84alkaloid metabolic process (GO:0009820)3.02235637
85regulation of collateral sprouting (GO:0048670)2.99692333
86phenylpropanoid metabolic process (GO:0009698)2.98895011
87neuronal ion channel clustering (GO:0045161)2.98205088
88cGMP-mediated signaling (GO:0019934)2.97415100
89fructose metabolic process (GO:0006000)2.90923590
90layer formation in cerebral cortex (GO:0021819)2.90495391
91glutamine family amino acid biosynthetic process (GO:0009084)2.90436059
92complement activation, classical pathway (GO:0006958)2.87794632
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87328189
94cell-cell junction maintenance (GO:0045217)2.86556398
95epithelial structure maintenance (GO:0010669)2.85156531
96very-low-density lipoprotein particle assembly (GO:0034379)2.84637127
97vocalization behavior (GO:0071625)2.83927392
98positive regulation of lipid catabolic process (GO:0050996)2.81914352
99dendrite morphogenesis (GO:0048813)2.80597065
100proline transport (GO:0015824)2.79841589
101adhesion of symbiont to host (GO:0044406)2.79306533
102fatty acid elongation (GO:0030497)2.78406683
103virion attachment to host cell (GO:0019062)2.77664896
104adhesion of symbiont to host cell (GO:0044650)2.77664896
105exploration behavior (GO:0035640)2.76402061
106apical protein localization (GO:0045176)2.76188990
107midgut development (GO:0007494)2.75143176
108establishment of mitochondrion localization (GO:0051654)2.75032742
109peptidyl-cysteine modification (GO:0018198)2.74605503
110vesicle transport along microtubule (GO:0047496)2.74526541
111regulation of cGMP biosynthetic process (GO:0030826)2.74446848
112serine transport (GO:0032329)2.74214708
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.71044108
114negative regulation of axon extension (GO:0030517)2.70348523
115drug transmembrane transport (GO:0006855)2.70250649
116neuron recognition (GO:0008038)2.70009491
117organelle transport along microtubule (GO:0072384)2.69874648
118neurofilament cytoskeleton organization (GO:0060052)2.69083314
119L-amino acid import (GO:0043092)2.68597616
120mating behavior (GO:0007617)2.68447815
121regulation of triglyceride catabolic process (GO:0010896)2.66848209
122barbed-end actin filament capping (GO:0051016)2.66507926
123regulation of cholesterol metabolic process (GO:0090181)2.65532332
124cellular response to epinephrine stimulus (GO:0071872)2.64765268
125asymmetric protein localization (GO:0008105)2.62725572
126dendritic spine morphogenesis (GO:0060997)2.62465770
127primary alcohol metabolic process (GO:0034308)2.61602935
128phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.60973289
129protein retention in ER lumen (GO:0006621)2.60969890
130actin filament capping (GO:0051693)2.58911113
131arginine catabolic process (GO:0006527)2.58586423
132regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.58470391
133phospholipid efflux (GO:0033700)2.58400508
134protein palmitoylation (GO:0018345)2.57725832
135drug transport (GO:0015893)2.57531315
136glucocorticoid biosynthetic process (GO:0006704)2.57522453
137sodium ion export (GO:0071436)2.57434955
138regulation of synaptic vesicle transport (GO:1902803)2.57271455
139regulation of cholesterol esterification (GO:0010872)2.55270373
140digestive system process (GO:0022600)2.54566348
141regulation of protein activation cascade (GO:2000257)2.54154778
142receptor recycling (GO:0001881)2.54094475
143cellular response to pH (GO:0071467)2.53433893
144regulation of neuronal synaptic plasticity (GO:0048168)2.53236417
145clathrin coat assembly (GO:0048268)2.51946421
146neurotransmitter catabolic process (GO:0042135)2.51380962
147enteric nervous system development (GO:0048484)2.49716923
148peripheral nervous system axon ensheathment (GO:0032292)2.48899089
149myelination in peripheral nervous system (GO:0022011)2.48899089
150phosphate ion transmembrane transport (GO:0035435)2.48819524
151protein localization to synapse (GO:0035418)2.48782463
152regulation of axonogenesis (GO:0050770)2.47801763
153eye photoreceptor cell differentiation (GO:0001754)2.47191411
154photoreceptor cell differentiation (GO:0046530)2.47191411
155membrane assembly (GO:0071709)2.46561560
156substantia nigra development (GO:0021762)2.46320794
157neuronal action potential (GO:0019228)2.46068824
158sulfate transmembrane transport (GO:1902358)2.45273116
159negative regulation of actin filament depolymerization (GO:0030835)2.45131697
160complement activation (GO:0006956)2.45067277
161citrulline metabolic process (GO:0000052)2.44918892
162presynaptic membrane assembly (GO:0097105)2.44240630
163regulation of complement activation (GO:0030449)2.43478126
164negative regulation of blood coagulation (GO:0030195)2.43228544
165negative regulation of hemostasis (GO:1900047)2.43228544
166excretion (GO:0007588)2.41726989
167regulation of extracellular matrix disassembly (GO:0010715)2.41031161
168regulation of synapse structural plasticity (GO:0051823)2.40732474
169negative regulation of sterol transport (GO:0032372)2.40666166
170negative regulation of cholesterol transport (GO:0032375)2.40666166
171response to methylmercury (GO:0051597)2.40098384
172glyoxylate metabolic process (GO:0046487)2.39644903
173ionotropic glutamate receptor signaling pathway (GO:0035235)2.39149337
174positive regulation of lipoprotein lipase activity (GO:0051006)2.38805172
175positive regulation of triglyceride lipase activity (GO:0061365)2.38805172
176desmosome organization (GO:0002934)2.38612589
177axon cargo transport (GO:0008088)2.38026060
178semaphorin-plexin signaling pathway (GO:0071526)2.38022817
179cellular response to catecholamine stimulus (GO:0071870)2.37990949
180cellular response to monoamine stimulus (GO:0071868)2.37990949
181regulation of long-term neuronal synaptic plasticity (GO:0048169)2.37858084
182protein targeting to plasma membrane (GO:0072661)2.37752658
183regulation of neuron projection regeneration (GO:0070570)2.37303169
184regulation of axon regeneration (GO:0048679)2.37303169
185membrane hyperpolarization (GO:0060081)2.36928540
186leukocyte migration involved in inflammatory response (GO:0002523)2.34680292
187regulation of actin filament depolymerization (GO:0030834)2.34060954
188potassium ion homeostasis (GO:0055075)2.34004695
189negative regulation of neuron projection development (GO:0010977)2.33699279
190cholesterol biosynthetic process (GO:0006695)2.32237685
191positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.32211881
192negative regulation of cell projection organization (GO:0031345)2.31688272
193neuromuscular process controlling balance (GO:0050885)2.31536193
194neuron remodeling (GO:0016322)2.31437671
195neurotransmitter secretion (GO:0007269)2.31334324
196synaptic transmission, glutamatergic (GO:0035249)2.30905464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.65582304
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.65152792
3EZH2_22144423_ChIP-Seq_EOC_Human2.62074821
4DROSHA_22980978_ChIP-Seq_HELA_Human2.61590298
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.53623002
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48595874
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47912752
8* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38028345
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.29200700
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24867133
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23653403
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.20718251
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20078972
14* ESR2_21235772_ChIP-Seq_MCF-7_Human2.16130285
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15104997
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15104997
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11803539
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.07694878
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.07690211
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07586527
21GBX2_23144817_ChIP-Seq_PC3_Human2.04961935
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.03791144
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01963015
24ZNF263_19887448_ChIP-Seq_K562_Human1.99764388
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95939108
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95534526
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95013454
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94274860
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.93164477
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91939673
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83713139
32REST_21632747_ChIP-Seq_MESCs_Mouse1.79318917
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.76480691
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.71108188
35KDM2B_26808549_Chip-Seq_K562_Human1.70750116
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.68176611
37GATA4_25053715_ChIP-Seq_YYC3_Human1.67736581
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66430914
39AR_21572438_ChIP-Seq_LNCaP_Human1.66310799
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64785755
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63956417
42CLOCK_20551151_ChIP-Seq_293T_Human1.62890974
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59908114
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.58827242
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.57834196
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54348945
47* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54021136
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53673613
49* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52457286
50* REST_18959480_ChIP-ChIP_MESCs_Mouse1.50960935
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48274255
52GATA6_25053715_ChIP-Seq_YYC3_Human1.48128617
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.47889696
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45043256
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43241684
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41842429
57GATA1_19941826_ChIP-Seq_K562_Human1.41411670
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40208081
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.39897344
60* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39734197
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39301131
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36797033
63AHR_22903824_ChIP-Seq_MCF-7_Human1.34995415
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34518834
65* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33149005
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32915037
67SOX2_20726797_ChIP-Seq_SW620_Human1.30745017
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27835837
69* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27726356
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23670459
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.23585563
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22987930
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22386732
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22339698
75* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22154209
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22115879
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21703176
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20959655
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20840102
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19071417
81* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18384099
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.18352788
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.18122704
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18054566
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17673333
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16627569
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16167792
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15057900
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14779156
90* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13777401
91* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12609996
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.12325949
93SMC4_20622854_ChIP-Seq_HELA_Human1.12052793
94* LXR_22292898_ChIP-Seq_THP-1_Human1.11695362
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11215492
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11160589
97ZNF274_21170338_ChIP-Seq_K562_Hela1.11086782
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.09979383
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09461875
100CTCF_27219007_Chip-Seq_Bcells_Human1.09058597
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08343121
102* KLF5_25053715_ChIP-Seq_YYC3_Human1.07677442
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07081722
104KDM2B_26808549_Chip-Seq_DND41_Human1.07017449
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06725302
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06582544
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.05558921
108* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05068239
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04726623
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04563409
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.04271552
112TP63_22573176_ChIP-Seq_HFKS_Human1.02764074
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02755479
114P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02254517
115RACK7_27058665_Chip-Seq_MCF-7_Human1.02119428
116CREB1_26743006_Chip-Seq_LNCaP_Human1.01818494
117* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01793839
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01106881
119CDX2_20551321_ChIP-Seq_CACO-2_Human1.00242499
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.00127943
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99819826
122* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98559754
123* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98522913
124* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98405774
125* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97587068
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.97219594
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.97026006
128GATA2_19941826_ChIP-Seq_K562_Human0.96264413
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96057027
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.94864193
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94366307
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93552794
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.93546885
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93532490
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93415262
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92620611
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91777309
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91657088
139SA1_27219007_Chip-Seq_Bcells_Human0.90938805
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90756553
141TAF15_26573619_Chip-Seq_HEK293_Human0.90705442
142CTCF_20526341_ChIP-Seq_ESCs_Human0.90694553
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90411731
144* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89431038
145* ESR1_21235772_ChIP-Seq_MCF-7_Human0.89381234
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88505736
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88429025
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88394522
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.88305901
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88198309
151TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87759906
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87278070
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86966935
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86649160
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.86440222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.77513707
2MP0002139_abnormal_hepatobiliary_system5.73566121
3MP0004859_abnormal_synaptic_plasticity4.45675371
4MP0004270_analgesia4.31718807
5MP0005085_abnormal_gallbladder_physiolo3.97721168
6MP0004858_abnormal_nervous_system3.67408781
7MP0005365_abnormal_bile_salt3.62617189
8MP0001666_abnormal_nutrient_absorption3.29435329
9MP0002735_abnormal_chemical_nociception3.17999766
10MP0001968_abnormal_touch/_nociception3.08300630
11MP0003880_abnormal_central_pattern3.04550174
12MP0002733_abnormal_thermal_nociception2.90277792
13MP0002734_abnormal_mechanical_nocicepti2.89253793
14MP0000920_abnormal_myelination2.87151635
15MP0003329_amyloid_beta_deposits2.77480015
16MP0003635_abnormal_synaptic_transmissio2.75383597
17MP0009840_abnormal_foam_cell2.69903715
18MP0009379_abnormal_foot_pigmentation2.68739829
19MP0004885_abnormal_endolymph2.61032175
20MP0002736_abnormal_nociception_after2.55083881
21MP0008875_abnormal_xenobiotic_pharmacok2.50170223
22MP0001970_abnormal_pain_threshold2.49360358
23MP0002064_seizures2.33790625
24MP0010234_abnormal_vibrissa_follicle2.30797660
25MP0009745_abnormal_behavioral_response2.23520822
26MP0002272_abnormal_nervous_system2.22782549
27MP0004019_abnormal_vitamin_homeostasis2.17893452
28MP0002822_catalepsy2.04611268
29MP0000778_abnormal_nervous_system2.04491645
30MP0004264_abnormal_extraembryonic_tissu2.03432887
31MP0003868_abnormal_feces_composition2.03088157
32MP0000566_synostosis1.97560714
33MP0002063_abnormal_learning/memory/cond1.96560096
34MP0005409_darkened_coat_color1.91038349
35MP0003183_abnormal_peptide_metabolism1.90342972
36MP0003705_abnormal_hypodermis_morpholog1.89849548
37MP0003634_abnormal_glial_cell1.89629750
38MP0008438_abnormal_cutaneous_collagen1.89337754
39MP0005423_abnormal_somatic_nervous1.74478647
40MP0001440_abnormal_grooming_behavior1.72797538
41MP0009780_abnormal_chondrocyte_physiolo1.72672044
42MP0000955_abnormal_spinal_cord1.72381181
43MP0002572_abnormal_emotion/affect_behav1.71272113
44MP0010386_abnormal_urinary_bladder1.70577951
45MP0005257_abnormal_intraocular_pressure1.69555483
46MP0004147_increased_porphyrin_level1.68867261
47MP0010352_gastrointestinal_tract_polyps1.68507081
48MP0002249_abnormal_larynx_morphology1.68363289
49MP0003879_abnormal_hair_cell1.63923269
50MP0003632_abnormal_nervous_system1.62410186
51MP0004811_abnormal_neuron_physiology1.62164717
52MP0002876_abnormal_thyroid_physiology1.60762383
53MP0001905_abnormal_dopamine_level1.60273901
54MP0005670_abnormal_white_adipose1.57762742
55MP0009046_muscle_twitch1.55609075
56MP0002184_abnormal_innervation1.55140430
57MP0003252_abnormal_bile_duct1.54657806
58MP0006276_abnormal_autonomic_nervous1.53994991
59MP0002138_abnormal_hepatobiliary_system1.51282411
60MP0004742_abnormal_vestibular_system1.50746979
61MP0003690_abnormal_glial_cell1.49241547
62MP0010329_abnormal_lipoprotein_level1.48129980
63MP0001664_abnormal_digestion1.46891730
64MP0001486_abnormal_startle_reflex1.46639980
65MP0008569_lethality_at_weaning1.45020040
66MP0002067_abnormal_sensory_capabilities1.44787475
67MP0002882_abnormal_neuron_morphology1.44458001
68MP0010155_abnormal_intestine_physiology1.44191002
69MP0000477_abnormal_intestine_morphology1.43171403
70MP0000462_abnormal_digestive_system1.42902751
71MP0002909_abnormal_adrenal_gland1.42135708
72MP0000604_amyloidosis1.38277402
73MP0000678_abnormal_parathyroid_gland1.35107178
74MP0005332_abnormal_amino_acid1.33587299
75MP0003631_nervous_system_phenotype1.31382946
76MP0003866_abnormal_defecation1.30378835
77MP0000537_abnormal_urethra_morphology1.29806916
78MP0003656_abnormal_erythrocyte_physiolo1.28971532
79MP0010678_abnormal_skin_adnexa1.28473828
80MP0010368_abnormal_lymphatic_system1.28312062
81MP0002229_neurodegeneration1.27835477
82MP0001501_abnormal_sleep_pattern1.27776073
83MP0003633_abnormal_nervous_system1.27320655
84MP0001485_abnormal_pinna_reflex1.27174930
85MP0001986_abnormal_taste_sensitivity1.25889745
86MP0002751_abnormal_autonomic_nervous1.22508377
87MP0003172_abnormal_lysosome_physiology1.20366011
88MP0001663_abnormal_digestive_system1.19797316
89MP0009643_abnormal_urine_homeostasis1.18858042
90MP0005310_abnormal_salivary_gland1.17730389
91MP0004782_abnormal_surfactant_physiolog1.17382627
92MP0002066_abnormal_motor_capabilities/c1.15855016
93MP0001529_abnormal_vocalization1.15362012
94MP0002896_abnormal_bone_mineralization1.14584655
95MP0001348_abnormal_lacrimal_gland1.13165835
96MP0005166_decreased_susceptibility_to1.10476636
97MP0004924_abnormal_behavior1.09654470
98MP0005386_behavior/neurological_phenoty1.09654470
99MP0005623_abnormal_meninges_morphology1.09458847
100MP0001756_abnormal_urination1.08036910
101MP0002557_abnormal_social/conspecific_i1.05206749
102MP0000747_muscle_weakness0.99187817
103MP0005636_abnormal_mineral_homeostasis0.98931483
104MP0000538_abnormal_urinary_bladder0.98634334
105MP0009384_cardiac_valve_regurgitation0.98632599
106MP0000534_abnormal_ureter_morphology0.98002914
107MP0001958_emphysema0.97971438
108MP0000490_abnormal_crypts_of0.97674181
109MP0005503_abnormal_tendon_morphology0.97248333
110MP0003045_fibrosis0.96991741
111MP0001188_hyperpigmentation0.96207651
112MP0005058_abnormal_lysosome_morphology0.93916322
113MP0002098_abnormal_vibrissa_morphology0.93809047
114MP0002118_abnormal_lipid_homeostasis0.92016129
115MP0003075_altered_response_to0.90961990
116MP0005171_absent_coat_pigmentation0.89561940
117MP0002152_abnormal_brain_morphology0.88025872
118MP0000465_gastrointestinal_hemorrhage0.86613756
119MP0010030_abnormal_orbit_morphology0.86365057
120MP0003300_gastrointestinal_ulcer0.83634459
121MP0002136_abnormal_kidney_physiology0.82946453
122MP0002752_abnormal_somatic_nervous0.82781485
123MP0005023_abnormal_wound_healing0.79566802
124MP0008004_abnormal_stomach_pH0.79091927
125MP0005645_abnormal_hypothalamus_physiol0.78749027
126MP0008874_decreased_physiological_sensi0.77590201
127MP0001299_abnormal_eye_distance/0.77162004
128MP0001849_ear_inflammation0.76934182
129MP0003191_abnormal_cellular_cholesterol0.76124879
130MP0004142_abnormal_muscle_tone0.75893613
131MP0008872_abnormal_physiological_respon0.74975814
132MP0001963_abnormal_hearing_physiology0.74437208
133MP0002877_abnormal_melanocyte_morpholog0.72818134
134MP0001765_abnormal_ion_homeostasis0.71356656
135MP0002653_abnormal_ependyma_morphology0.71308621
136MP0005275_abnormal_skin_tensile0.70268014
137MP0004134_abnormal_chest_morphology0.69754001
138MP0003279_aneurysm0.69559548
139MP0001270_distended_abdomen0.69558124
140MP0004272_abnormal_basement_membrane0.69250151
141MP0010771_integument_phenotype0.69013575
142MP0002089_abnormal_postnatal_growth/wei0.68943905
143MP0000383_abnormal_hair_follicle0.68524160
144MP0005501_abnormal_skin_physiology0.66793031
145MP0003119_abnormal_digestive_system0.66785305
146MP0001764_abnormal_homeostasis0.66782259
147MP0000230_abnormal_systemic_arterial0.66367042
148MP0002796_impaired_skin_barrier0.65662217
149MP0000609_abnormal_liver_physiology0.65179595
150MP0000467_abnormal_esophagus_morphology0.64398923
151MP0005167_abnormal_blood-brain_barrier0.62155195
152MP0003122_maternal_imprinting0.61990564
153MP0003091_abnormal_cell_migration0.61455399
154MP0002090_abnormal_vision0.60024831
155MP0000762_abnormal_tongue_morphology0.59950740
156MP0002069_abnormal_eating/drinking_beha0.59517674
157MP0002971_abnormal_brown_adipose0.59243922
158MP0003283_abnormal_digestive_organ0.58370262
159MP0005319_abnormal_enzyme/_coenzyme0.58183949
160MP0000049_abnormal_middle_ear0.57571114
161MP0005367_renal/urinary_system_phenotyp0.57388307
162MP0000516_abnormal_urinary_system0.57388307
163MP0005595_abnormal_vascular_smooth0.57360813
164MP0005381_digestive/alimentary_phenotyp0.57202402
165MP0005584_abnormal_enzyme/coenzyme_acti0.57032984
166MP0004043_abnormal_pH_regulation0.56895648
167MP0005165_increased_susceptibility_to0.56626417
168MP0001502_abnormal_circadian_rhythm0.56041305
169MP0002932_abnormal_joint_morphology0.55879418
170MP0005508_abnormal_skeleton_morphology0.54801362
171MP0000751_myopathy0.52792602

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)6.27879254
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.82369647
3Hyperactive renin-angiotensin system (HP:0000841)5.40647745
4Myokymia (HP:0002411)4.88949600
5Termporal pattern (HP:0011008)4.78089530
6Insidious onset (HP:0003587)4.78089530
7Abnormality of the corticospinal tract (HP:0002492)4.43598243
8Supranuclear gaze palsy (HP:0000605)4.37966840
9Degeneration of the lateral corticospinal tracts (HP:0002314)4.25665628
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.25665628
11Hydroxyprolinuria (HP:0003080)4.19128268
12Abnormality of proline metabolism (HP:0010907)4.19128268
13Systemic lupus erythematosus (HP:0002725)4.07157206
14Action tremor (HP:0002345)4.07049680
15Neurofibrillary tangles (HP:0002185)4.00501479
16Complement deficiency (HP:0004431)3.93478840
17Decreased circulating renin level (HP:0003351)3.89290995
18Akinesia (HP:0002304)3.84992659
19Malnutrition (HP:0004395)3.80576699
20Visual hallucinations (HP:0002367)3.78534424
21Abnormality of complement system (HP:0005339)3.73465726
22Flat acetabular roof (HP:0003180)3.66229946
23Conjugated hyperbilirubinemia (HP:0002908)3.53762038
24Cerebral inclusion bodies (HP:0100314)3.53433133
25Abnormality of renin-angiotensin system (HP:0000847)3.53205410
26Peripheral hypomyelination (HP:0007182)3.47783678
27Ileus (HP:0002595)3.44897311
28Sensory axonal neuropathy (HP:0003390)3.35328026
29Ulnar claw (HP:0001178)3.32221299
30Metabolic alkalosis (HP:0200114)3.31878000
31Ankle clonus (HP:0011448)3.27223379
32Spastic gait (HP:0002064)3.21238120
33Fat malabsorption (HP:0002630)3.19537817
34Alkalosis (HP:0001948)3.17592960
35Protrusio acetabuli (HP:0003179)3.11219432
36Intrahepatic cholestasis (HP:0001406)3.09893537
37Onion bulb formation (HP:0003383)3.03789258
38Neonatal short-limb short stature (HP:0008921)3.03576522
39Hypobetalipoproteinemia (HP:0003563)3.02464304
40Broad metatarsal (HP:0001783)2.99120563
41Xanthomatosis (HP:0000991)2.96244764
42Distal upper limb amyotrophy (HP:0007149)2.95291042
43Upper limb amyotrophy (HP:0009129)2.95291042
44Focal motor seizures (HP:0011153)2.91957969
45Hyperparathyroidism (HP:0000843)2.89358032
46Intention tremor (HP:0002080)2.89222385
47Abdominal distention (HP:0003270)2.84339095
48Focal seizures (HP:0007359)2.83463128
49Atonic seizures (HP:0010819)2.77511431
50Thin bony cortex (HP:0002753)2.69491720
51Hyperaldosteronism (HP:0000859)2.66173387
52Premature rupture of membranes (HP:0001788)2.64884510
53Hypothermia (HP:0002045)2.62973886
54Glomerulonephritis (HP:0000099)2.62810905
55Segmental peripheral demyelination/remyelination (HP:0003481)2.61311031
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60517721
57Chronic bronchitis (HP:0004469)2.59059328
58Retinal dysplasia (HP:0007973)2.58002055
59Abnormality of vitamin metabolism (HP:0100508)2.57699920
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56259510
61Abnormality of chloride homeostasis (HP:0011422)2.56178729
62Mildly elevated creatine phosphokinase (HP:0008180)2.55775836
63Deep venous thrombosis (HP:0002625)2.51420453
64Pheochromocytoma (HP:0002666)2.50642375
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48822854
66Dysmetria (HP:0001310)2.48492557
67Hammertoe (HP:0001765)2.46060461
68Abnormality of the nasal mucosa (HP:0000433)2.44947649
69Focal segmental glomerulosclerosis (HP:0000097)2.42252826
70Megalencephaly (HP:0001355)2.41719929
71Widely patent fontanelles and sutures (HP:0004492)2.40107289
72Hand muscle atrophy (HP:0009130)2.38539362
73Abnormality of carpal bone ossification (HP:0006257)2.35480056
74Mutism (HP:0002300)2.33700266
75Papilledema (HP:0001085)2.30815063
76Wide cranial sutures (HP:0010537)2.30740786
77Nephritis (HP:0000123)2.30173428
78Abnormality of the vitamin B12 metabolism (HP:0004341)2.29786526
79Vascular tortuosity (HP:0004948)2.28910793
80Increased cerebral lipofuscin (HP:0011813)2.28735759
81Shallow orbits (HP:0000586)2.28155247
82Urinary bladder sphincter dysfunction (HP:0002839)2.27803220
83Abnormality of glycine metabolism (HP:0010895)2.21907774
84Abnormality of serine family amino acid metabolism (HP:0010894)2.21907774
85Depression (HP:0000716)2.21561271
86Failure to thrive in infancy (HP:0001531)2.21157679
87Hyperglycinuria (HP:0003108)2.20112218
88Abnormality of the distal phalanx of the thumb (HP:0009617)2.18242554
89Congenital sensorineural hearing impairment (HP:0008527)2.17694560
90Neuroendocrine neoplasm (HP:0100634)2.17564407
91Lower limb muscle weakness (HP:0007340)2.14035408
92Autoamputation (HP:0001218)2.13883417
93Hypomagnesemia (HP:0002917)2.13874266
94Rapidly progressive (HP:0003678)2.13536300
95Postural tremor (HP:0002174)2.12496259
96Type II lissencephaly (HP:0007260)2.11575031
97Nephrolithiasis (HP:0000787)2.11512353
98Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.11494630
99Distal sensory impairment (HP:0002936)2.11436140
100Abnormality of magnesium homeostasis (HP:0004921)2.11007025
101Nasal polyposis (HP:0100582)2.09390735
102Arterial tortuosity (HP:0005116)2.09040684
103Amblyopia (HP:0000646)2.08704333
104Hypoplasia of the brainstem (HP:0002365)2.08387564
105Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08387564
106Apathy (HP:0000741)2.08076098
107Increased neuronal autofluorescent lipopigment (HP:0002074)2.07985099
108Cervical subluxation (HP:0003308)2.06790667
109Insomnia (HP:0100785)2.05047665
110Epileptic encephalopathy (HP:0200134)2.02673416
111Abnormality of vitamin B metabolism (HP:0004340)2.02321719
112Aortic aneurysm (HP:0004942)2.00286489
113Hypolipoproteinemia (HP:0010981)1.99331673
114Abnormal ossification of hand bones (HP:0005921)1.99330827
115Progressive inability to walk (HP:0002505)1.99285315
116Progressive cerebellar ataxia (HP:0002073)1.99073755
117Cerebral hemorrhage (HP:0001342)1.98678275
118Morphological abnormality of the inner ear (HP:0011390)1.97943200
119Parakeratosis (HP:0001036)1.97656630
120Abnormality of calcium-phosphate metabolism (HP:0100530)1.96272543
121Cardiovascular calcification (HP:0011915)1.96122045
122Vascular calcification (HP:0004934)1.95231376
123Exotropia (HP:0000577)1.94212482
124Spinal cord compression (HP:0002176)1.93678397
125Hypoventilation (HP:0002791)1.93547165
126Hyperammonemia (HP:0001987)1.93346545
127Esophageal atresia (HP:0002032)1.93128674
128Abnormal respiratory motile cilium physiology (HP:0012261)1.92904386
129Foot dorsiflexor weakness (HP:0009027)1.92169546
130Steppage gait (HP:0003376)1.92135499
131Slow saccadic eye movements (HP:0000514)1.91429189
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91346409
133Hyperuricemia (HP:0002149)1.91221229
134Increased purine levels (HP:0004368)1.91221229
135Abnormal tarsal ossification (HP:0008369)1.90682238
136Premature skin wrinkling (HP:0100678)1.89910308
137Renal tubular acidosis (HP:0001947)1.89697540
138Abnormal autonomic nervous system physiology (HP:0012332)1.89428998
139Rhinitis (HP:0012384)1.89416091
140Hypotension (HP:0002615)1.89345026
141Hypokalemia (HP:0002900)1.87872662
142Urinary urgency (HP:0000012)1.87792282
143Abnormal respiratory epithelium morphology (HP:0012253)1.87613673
144Abnormal respiratory motile cilium morphology (HP:0005938)1.87613673
145Diminished motivation (HP:0000745)1.87272971
146Macroorchidism (HP:0000053)1.87161874
147Abnormal eating behavior (HP:0100738)1.86411646
148Buphthalmos (HP:0000557)1.86394673
149Bronchomalacia (HP:0002780)1.86036675
150Confusion (HP:0001289)1.85857373
151Abnormality of pyrimidine metabolism (HP:0004353)1.85791391
152Glomerulosclerosis (HP:0000096)1.85569840
153Diminished movement (HP:0002374)1.85439624
154Cerebral hypomyelination (HP:0006808)1.85039595
155Clonus (HP:0002169)1.84091450
156Steatorrhea (HP:0002570)1.83384350
157Obstructive sleep apnea (HP:0002870)1.82848477
158Alacrima (HP:0000522)1.82719920
159Flattened epiphyses (HP:0003071)1.82672301
160Barrel-shaped chest (HP:0001552)1.82312600
161Scanning speech (HP:0002168)1.81653953
162Decreased motor nerve conduction velocity (HP:0003431)1.81033756
163Abnormality of the distal phalanges of the toes (HP:0010182)1.80931942
164Loss of speech (HP:0002371)1.80685558
165Gout (HP:0001997)1.80177179
166Partial duplication of thumb phalanx (HP:0009944)1.80119596
167Abnormal hand bone ossification (HP:0010660)1.79771032
168Visceral angiomatosis (HP:0100761)1.79074477
169Aortic dissection (HP:0002647)1.78869447
170Protuberant abdomen (HP:0001538)1.77522774
171Truncal ataxia (HP:0002078)1.77108864
172Abnormal ciliary motility (HP:0012262)1.76280213
173Milia (HP:0001056)1.75813777
174Ankle contracture (HP:0006466)1.75045502
175Turricephaly (HP:0000262)1.74937391
176Open mouth (HP:0000194)1.74923271
177Postural instability (HP:0002172)1.74655254
178Bladder diverticulum (HP:0000015)1.74585192
179Abnormality of nucleobase metabolism (HP:0010932)1.73432342
180Neuronal loss in central nervous system (HP:0002529)1.73120132
181Neoplasm of the peripheral nervous system (HP:0100007)1.72566513
182Stereotypic behavior (HP:0000733)1.72464716
183Dysautonomia (HP:0002459)1.72350873
184Right ventricular cardiomyopathy (HP:0011663)1.72337923
185Stridor (HP:0010307)1.72307912
186Abnormal auditory evoked potentials (HP:0006958)1.71668818
187Aneurysm (HP:0002617)1.70909918
188Abnormality of potassium homeostasis (HP:0011042)1.70632522
189Deep palmar crease (HP:0006191)1.70426355
190Aplasia involving bones of the upper limbs (HP:0009823)1.70320444
191Aplasia of the phalanges of the hand (HP:0009802)1.70320444
192Aplasia involving bones of the extremities (HP:0009825)1.70320444
193Polyphagia (HP:0002591)1.69726256
194Hypercortisolism (HP:0001578)1.69662190
195Delayed CNS myelination (HP:0002188)1.69578715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.20003402
2NTRK13.95826507
3STK393.77353398
4MAP3K93.46448999
5MAP3K23.30151198
6ERN13.15453626
7EPHB23.00205104
8KSR22.89036668
9TNIK2.59595503
10ACVR1B2.55728138
11OXSR12.43441496
12ICK2.43064674
13EPHB12.41560720
14MET2.24649968
15PRKG22.21498376
16MST42.07003061
17TRIB31.96121734
18CDK191.95049548
19TESK11.92828891
20NTRK31.89733732
21PDGFRA1.87973077
22MINK11.85164410
23DDR21.79209420
24MARK11.79046440
25EPHA21.77993971
26UHMK11.77670076
27MATK1.77099365
28EPHA31.74164574
29FGFR41.70786395
30MST1R1.64401016
31MYLK1.57055780
32EEF2K1.56443270
33PAK61.54288919
34ARAF1.52683668
35RET1.49985959
36PTK61.44993096
37WNK41.43969893
38LIMK11.43912225
39MAP3K101.32378811
40TYRO31.27671944
41PAK41.23397120
42PTK21.22791387
43GRK51.21629463
44CASK1.20916549
45WNK11.19565176
46CDK51.19470335
47LMTK21.19051349
48ROCK21.18464352
49BCR1.18360943
50MAPKAPK51.17334987
51MAPK151.14910411
52CSNK1G31.07777413
53EPHA41.07724652
54FER1.07142141
55MAP3K41.07043899
56SMG11.07004536
57CSNK1G21.06986779
58SIK11.06828632
59FES1.04544950
60MAP2K20.98873588
61FGR0.96502626
62CDC42BPA0.93085320
63DAPK20.91156130
64CDK140.91035251
65PNCK0.90632403
66RIPK40.90172531
67MAP3K10.89852858
68MAP3K130.88733708
69MAP2K10.88368498
70MAPK130.87960379
71TESK20.86238782
72CSNK1A1L0.85798271
73RPS6KA20.83671520
74CAMKK10.81958897
75MAP3K30.81666189
76CAMK2B0.78967983
77PINK10.76606458
78PAK30.76394595
79ABL20.76046936
80PRKD20.75677595
81CAMKK20.75589965
82ERBB40.73521665
83CDK150.72785992
84CAMK2D0.72324982
85FYN0.70854424
86CDK180.70143187
87DYRK1B0.70112170
88PDGFRB0.69685403
89STK380.66974971
90PKN20.65857275
91PKN10.65317326
92RPS6KB20.63237842
93CDK11A0.62898466
94FGFR20.62725264
95SCYL20.60851350
96ROCK10.60619933
97MAPKAPK30.60572825
98MAP3K120.60402321
99HIPK20.60109327
100PDPK10.59434971
101MARK20.58695963
102SGK2230.58538797
103SGK4940.58538797
104PRKCE0.57530451
105BMX0.55798129
106CSNK1G10.55567233
107STK240.55433690
108IRAK20.54729709
109PRKD30.54264287
110PIK3CA0.53922693
111PDK10.52407985
112PRPF4B0.51903310
113NME10.51282506
114TAOK10.50495258
115PRKCI0.50207607
116PRKCZ0.49912970
117NTRK20.49870430
118MAPK110.49744673
119SRC0.48450969
120STK110.48118722
121LATS20.47131098
122CAMK2A0.45801889
123ALK0.45153574
124LATS10.44419304
125RAF10.44407689
126LRRK20.43149782
127PRKACG0.41188469
128ERBB20.41045100
129CAMK10.39917218
130DYRK20.39802147
131PHKG20.37874428
132PHKG10.37874428
133PRKAA20.37637080
134CAMK2G0.37605615
135NEK60.37532558
136PRKCH0.36512065
137KSR10.33504732
138FGFR30.32998392
139PAK20.31743253
140CAMK1G0.31605667
141PRKCA0.30945905
142MTOR0.30012383
143MAP2K70.29577437
144MAP3K60.29340860
145AKT30.27513305
146MAP3K70.24080258
147CSNK1A10.23304554

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.15109650
2Caffeine metabolism_Homo sapiens_hsa002322.99820837
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79817595
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.66906090
5Arginine biosynthesis_Homo sapiens_hsa002202.62935228
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.59690676
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57475979
8Retinol metabolism_Homo sapiens_hsa008302.55433643
9Histidine metabolism_Homo sapiens_hsa003402.49831317
10Chemical carcinogenesis_Homo sapiens_hsa052042.48864379
11Fat digestion and absorption_Homo sapiens_hsa049752.48397093
12Synaptic vesicle cycle_Homo sapiens_hsa047212.38161745
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29960864
14Bile secretion_Homo sapiens_hsa049762.13499321
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13014628
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03549662
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.95873890
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.94310429
19Salivary secretion_Homo sapiens_hsa049701.86470205
20Starch and sucrose metabolism_Homo sapiens_hsa005001.85822622
21Fatty acid degradation_Homo sapiens_hsa000711.82879274
22Renin-angiotensin system_Homo sapiens_hsa046141.82554499
23Phenylalanine metabolism_Homo sapiens_hsa003601.80368025
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73865798
25Axon guidance_Homo sapiens_hsa043601.73671151
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70002653
27Collecting duct acid secretion_Homo sapiens_hsa049661.67165342
28PPAR signaling pathway_Homo sapiens_hsa033201.67061028
29Glutamatergic synapse_Homo sapiens_hsa047241.63838432
30Cholinergic synapse_Homo sapiens_hsa047251.63346261
31Long-term potentiation_Homo sapiens_hsa047201.62522594
32Vitamin digestion and absorption_Homo sapiens_hsa049771.62491068
33Dorso-ventral axis formation_Homo sapiens_hsa043201.61672446
34Protein digestion and absorption_Homo sapiens_hsa049741.60936816
35Dopaminergic synapse_Homo sapiens_hsa047281.59819241
36Fructose and mannose metabolism_Homo sapiens_hsa000511.58950007
37Gastric acid secretion_Homo sapiens_hsa049711.58791548
38Vibrio cholerae infection_Homo sapiens_hsa051101.57654792
39Circadian entrainment_Homo sapiens_hsa047131.56232729
40Long-term depression_Homo sapiens_hsa047301.54477542
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51476160
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49480362
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.47102402
44Arginine and proline metabolism_Homo sapiens_hsa003301.46640661
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.46526439
46Serotonergic synapse_Homo sapiens_hsa047261.46255386
47Tyrosine metabolism_Homo sapiens_hsa003501.44544332
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42637563
49Steroid biosynthesis_Homo sapiens_hsa001001.41144674
50Linoleic acid metabolism_Homo sapiens_hsa005911.37824884
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36071808
52Complement and coagulation cascades_Homo sapiens_hsa046101.34896063
53GABAergic synapse_Homo sapiens_hsa047271.32775739
54Olfactory transduction_Homo sapiens_hsa047401.31830461
55Insulin secretion_Homo sapiens_hsa049111.31091856
56Ether lipid metabolism_Homo sapiens_hsa005651.30137009
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26509283
58Gap junction_Homo sapiens_hsa045401.26114274
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.25866053
60GnRH signaling pathway_Homo sapiens_hsa049121.24018871
61Amphetamine addiction_Homo sapiens_hsa050311.23700950
62ErbB signaling pathway_Homo sapiens_hsa040121.22351211
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21385773
64Glioma_Homo sapiens_hsa052141.20394036
65Estrogen signaling pathway_Homo sapiens_hsa049151.20338436
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19985017
67Endocytosis_Homo sapiens_hsa041441.18439188
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17301079
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15929555
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13448207
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13283624
72Pancreatic secretion_Homo sapiens_hsa049721.12831605
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12687588
74Sphingolipid signaling pathway_Homo sapiens_hsa040711.12454885
75Galactose metabolism_Homo sapiens_hsa000521.12001710
76Renin secretion_Homo sapiens_hsa049241.10071519
77Morphine addiction_Homo sapiens_hsa050321.10030894
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09916730
79Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08869298
80Tryptophan metabolism_Homo sapiens_hsa003801.08809809
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06173728
82Cocaine addiction_Homo sapiens_hsa050301.05527167
83Oxytocin signaling pathway_Homo sapiens_hsa049211.05066021
84Renal cell carcinoma_Homo sapiens_hsa052111.03861153
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03451056
86Choline metabolism in cancer_Homo sapiens_hsa052311.03440138
87Arachidonic acid metabolism_Homo sapiens_hsa005901.03178549
88Vascular smooth muscle contraction_Homo sapiens_hsa042701.03045395
89Taste transduction_Homo sapiens_hsa047421.02485365
90Tight junction_Homo sapiens_hsa045301.00782815
91Nicotine addiction_Homo sapiens_hsa050331.00630205
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98678107
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98181033
94Thyroid hormone synthesis_Homo sapiens_hsa049180.96166583
95Sphingolipid metabolism_Homo sapiens_hsa006000.94825908
96VEGF signaling pathway_Homo sapiens_hsa043700.94822988
97Thyroid cancer_Homo sapiens_hsa052160.94515402
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94445220
99Sulfur relay system_Homo sapiens_hsa041220.93959688
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93061720
101Butanoate metabolism_Homo sapiens_hsa006500.89780728
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87680794
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.85779031
104Type II diabetes mellitus_Homo sapiens_hsa049300.85752606
105Glutathione metabolism_Homo sapiens_hsa004800.85568010
106Mineral absorption_Homo sapiens_hsa049780.84490138
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83323795
108Melanogenesis_Homo sapiens_hsa049160.82887507
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82778717
110Glycerolipid metabolism_Homo sapiens_hsa005610.82042177
111Nitrogen metabolism_Homo sapiens_hsa009100.80847616
112Lysosome_Homo sapiens_hsa041420.80474585
113beta-Alanine metabolism_Homo sapiens_hsa004100.79606503
114Endometrial cancer_Homo sapiens_hsa052130.79398606
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79204696
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77792010
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77231288
118Platelet activation_Homo sapiens_hsa046110.76637881
119Ras signaling pathway_Homo sapiens_hsa040140.74276131
120ECM-receptor interaction_Homo sapiens_hsa045120.74135091
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73914274
122Peroxisome_Homo sapiens_hsa041460.73874718
123cAMP signaling pathway_Homo sapiens_hsa040240.73370072
124Biosynthesis of amino acids_Homo sapiens_hsa012300.72256951
125Calcium signaling pathway_Homo sapiens_hsa040200.71589224
126Fatty acid metabolism_Homo sapiens_hsa012120.71158736
127Non-small cell lung cancer_Homo sapiens_hsa052230.71077968
128Alcoholism_Homo sapiens_hsa050340.70182685
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.69856589
130Bladder cancer_Homo sapiens_hsa052190.69697870
131Salmonella infection_Homo sapiens_hsa051320.68970989
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68426586
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66837592
134Focal adhesion_Homo sapiens_hsa045100.66480281
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63660216
136mTOR signaling pathway_Homo sapiens_hsa041500.62599990
137Chronic myeloid leukemia_Homo sapiens_hsa052200.61499147
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60093195
139Prion diseases_Homo sapiens_hsa050200.60059281
140Sulfur metabolism_Homo sapiens_hsa009200.59289624
141Rap1 signaling pathway_Homo sapiens_hsa040150.59087402
142Other glycan degradation_Homo sapiens_hsa005110.58635574
143Pancreatic cancer_Homo sapiens_hsa052120.57438855
144N-Glycan biosynthesis_Homo sapiens_hsa005100.57293031
145Carbon metabolism_Homo sapiens_hsa012000.56708118
146Pyruvate metabolism_Homo sapiens_hsa006200.56102081
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55727793
148Amoebiasis_Homo sapiens_hsa051460.55697738
149Shigellosis_Homo sapiens_hsa051310.54670754
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53977086
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53715430
152Colorectal cancer_Homo sapiens_hsa052100.53670257
153Proteoglycans in cancer_Homo sapiens_hsa052050.53660579
154Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53163683
155Inositol phosphate metabolism_Homo sapiens_hsa005620.51069557
156Oocyte meiosis_Homo sapiens_hsa041140.50200314
157MAPK signaling pathway_Homo sapiens_hsa040100.50036706
158Phagosome_Homo sapiens_hsa041450.49627726
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49133500
160ABC transporters_Homo sapiens_hsa020100.42335414
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29912091
162Propanoate metabolism_Homo sapiens_hsa006400.29421745
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.27717578
164AMPK signaling pathway_Homo sapiens_hsa041520.25250257
165Metabolic pathways_Homo sapiens_hsa011000.25075670
166Adherens junction_Homo sapiens_hsa045200.24012790
167Insulin resistance_Homo sapiens_hsa049310.23704387
168Pentose phosphate pathway_Homo sapiens_hsa000300.23159983
169Glucagon signaling pathway_Homo sapiens_hsa049220.22468260
170Fatty acid biosynthesis_Homo sapiens_hsa000610.21471754
171Vitamin B6 metabolism_Homo sapiens_hsa007500.21250183
172Leukocyte transendothelial migration_Homo sapiens_hsa046700.20086978
173Cysteine and methionine metabolism_Homo sapiens_hsa002700.18015214

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