CAPN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.67664030
2COPI coating of Golgi vesicle (GO:0048205)5.57069737
3Golgi transport vesicle coating (GO:0048200)5.57069737
4nuclear pore organization (GO:0006999)4.78708111
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.70834624
6Golgi to endosome transport (GO:0006895)4.50436476
7pore complex assembly (GO:0046931)4.23948650
8pyrimidine dimer repair (GO:0006290)4.18929204
9dosage compensation (GO:0007549)4.17767053
10COPII vesicle coating (GO:0048208)4.08046118
11cytoplasmic mRNA processing body assembly (GO:0033962)3.92726304
12intestinal cholesterol absorption (GO:0030299)3.84623476
13neural tube formation (GO:0001841)3.81542859
14mitotic sister chromatid cohesion (GO:0007064)3.80979455
15retrograde transport, vesicle recycling within Golgi (GO:0000301)3.80328617
16interkinetic nuclear migration (GO:0022027)3.75560345
17positive regulation of histone deacetylation (GO:0031065)3.73696567
18macroautophagy (GO:0016236)3.68703532
19vesicle coating (GO:0006901)3.66958098
20iron ion import (GO:0097286)3.62713420
21oocyte development (GO:0048599)3.58929254
22ether lipid metabolic process (GO:0046485)3.58795025
23protein targeting to Golgi (GO:0000042)3.58485191
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57922494
25peptidyl-lysine dimethylation (GO:0018027)3.55973228
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.51168228
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.49621811
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.45609433
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.40797514
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37455751
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37455751
32positive regulation of nuclease activity (GO:0032075)3.37014419
33lysine catabolic process (GO:0006554)3.36469755
34lysine metabolic process (GO:0006553)3.36469755
35establishment of protein localization to Golgi (GO:0072600)3.33262414
36glucocorticoid receptor signaling pathway (GO:0042921)3.32153527
37protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.29704350
38vesicle transport along microtubule (GO:0047496)3.28114706
39tricarboxylic acid metabolic process (GO:0072350)3.27918763
40histone H3-K9 methylation (GO:0051567)3.27265413
41definitive hemopoiesis (GO:0060216)3.23259934
42regulation of centriole replication (GO:0046599)3.23237444
43nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.22860496
44corticosteroid receptor signaling pathway (GO:0031958)3.18485736
45mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.17272843
46positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.17272843
47valine metabolic process (GO:0006573)3.17233461
48peptidyl-lysine methylation (GO:0018022)3.16147643
49histone H3-K4 trimethylation (GO:0080182)3.16104542
50peptidyl-lysine trimethylation (GO:0018023)3.12369499
51protein targeting to vacuole (GO:0006623)3.10426191
52protein targeting to lysosome (GO:0006622)3.10426191
53establishment of protein localization to vacuole (GO:0072666)3.10426191
54growth hormone receptor signaling pathway (GO:0060396)3.07184621
55endoplasmic reticulum unfolded protein response (GO:0030968)3.06060206
56positive regulation of glycolytic process (GO:0045821)3.05995396
57negative regulation of cell killing (GO:0031342)3.05362005
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05362005
59regulation of establishment of cell polarity (GO:2000114)3.04592419
60early endosome to late endosome transport (GO:0045022)3.04083988
61cellular response to ethanol (GO:0071361)3.02698878
62regulation of nuclease activity (GO:0032069)3.01958823
63histone mRNA catabolic process (GO:0071044)3.01624285
64negative regulation of cell size (GO:0045792)2.99649462
65ER-nucleus signaling pathway (GO:0006984)2.98734595
66positive regulation of hormone biosynthetic process (GO:0046886)2.97678411
67acrosome assembly (GO:0001675)2.97146475
68antigen processing and presentation of endogenous antigen (GO:0019883)2.96389133
69endoplasmic reticulum organization (GO:0007029)2.96086638
70cellular response to prostaglandin stimulus (GO:0071379)2.94803954
71protein retention in ER lumen (GO:0006621)2.89640264
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89593337
73germ cell migration (GO:0008354)2.89497004
74nucleus localization (GO:0051647)2.89019483
75cellular response to unfolded protein (GO:0034620)2.87820769
76ribonucleoprotein complex disassembly (GO:0032988)2.86468928
77histone lysine demethylation (GO:0070076)2.86220103
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.86219070
79histone H3-K9 demethylation (GO:0033169)2.85771869
802-oxoglutarate metabolic process (GO:0006103)2.85257609
81histone H3-K9 modification (GO:0061647)2.82495962
82phospholipid dephosphorylation (GO:0046839)2.77478763
83histone demethylation (GO:0016577)2.75135741
84microtubule anchoring (GO:0034453)2.73998620
85N-glycan processing (GO:0006491)2.73808150
86UDP-N-acetylglucosamine metabolic process (GO:0006047)2.72294773
87ER to Golgi vesicle-mediated transport (GO:0006888)2.70798960
88embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69970527
89cellular response to topologically incorrect protein (GO:0035967)2.69686539
90positive regulation of mitotic sister chromatid separation (GO:1901970)2.69281265
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69281265
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69281265
93cellular response to growth hormone stimulus (GO:0071378)2.68931700
94regulation of transforming growth factor beta2 production (GO:0032909)2.68159090
95phosphatidylinositol dephosphorylation (GO:0046856)2.67746193
96positive regulation of cell cycle checkpoint (GO:1901978)2.67708013
97succinate metabolic process (GO:0006105)2.67114602
98histone lysine methylation (GO:0034968)2.66306324
99regulation of centrosome duplication (GO:0010824)2.65405268
100positive regulation of protein deacetylation (GO:0090312)2.63365857
101intra-Golgi vesicle-mediated transport (GO:0006891)2.62859817
102regulation of gamma-delta T cell differentiation (GO:0045586)2.62412318
103hepatocyte apoptotic process (GO:0097284)2.61674286
104cellular ketone body metabolic process (GO:0046950)2.61544611
105alpha-linolenic acid metabolic process (GO:0036109)2.60651965
106regulation of glycolytic process (GO:0006110)2.60343125
107positive regulation of gamma-delta T cell activation (GO:0046645)2.59512541
108Golgi to plasma membrane transport (GO:0006893)2.59301217
109intraciliary transport (GO:0042073)2.58700386
110exocrine pancreas development (GO:0031017)2.58273937
111regulation of histone H3-K27 methylation (GO:0061085)2.58100439
112androgen receptor signaling pathway (GO:0030521)2.57345780
113pyrimidine nucleobase catabolic process (GO:0006208)2.55400505
114dorsal/ventral axis specification (GO:0009950)2.54488362
115positive regulation of DNA-templated transcription, initiation (GO:2000144)2.54207002
116gene silencing by RNA (GO:0031047)2.51470001
117snRNA transcription (GO:0009301)2.50494727
118protein K11-linked deubiquitination (GO:0035871)2.49425976
119microtubule nucleation (GO:0007020)2.49091872
120regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48931481
121protein demethylation (GO:0006482)2.48444896
122protein dealkylation (GO:0008214)2.48444896
123monoubiquitinated protein deubiquitination (GO:0035520)2.48180756
124phosphatidylinositol phosphorylation (GO:0046854)2.48098186
125response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.47431197
126maternal placenta development (GO:0001893)2.47349219
127ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.47019422
128mRNA modification (GO:0016556)2.46908164
129glycoprotein catabolic process (GO:0006516)2.46535759
130negative regulation of fatty acid transport (GO:2000192)2.46370491
131sequestering of metal ion (GO:0051238)2.45343112
132negative regulation of neurotransmitter secretion (GO:0046929)2.43358405
133Golgi organization (GO:0007030)2.43116480
134Golgi to plasma membrane protein transport (GO:0043001)2.42877702
135regulation of fatty acid beta-oxidation (GO:0031998)2.42649806
136beta-amyloid metabolic process (GO:0050435)2.41958870
137stress granule assembly (GO:0034063)2.41897103
138regulation of endothelial cell chemotaxis (GO:2001026)2.41682469
139response to prostaglandin E (GO:0034695)2.41247520
140regulation of cAMP-dependent protein kinase activity (GO:2000479)2.41234861
141regulation of carbohydrate catabolic process (GO:0043470)2.40544973
142regulation of cellular carbohydrate catabolic process (GO:0043471)2.40544973
143negative regulation of histone methylation (GO:0031061)2.39938563
144negative regulation of complement activation (GO:0045916)2.39684583
145positive regulation of glycogen biosynthetic process (GO:0045725)2.39356226
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38534611
147dicarboxylic acid biosynthetic process (GO:0043650)2.38407097
148positive regulation of hormone metabolic process (GO:0032352)2.37351161
149establishment of nucleus localization (GO:0040023)2.36156570
150regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.36023993
151endocrine pancreas development (GO:0031018)2.35614391
152response to endoplasmic reticulum stress (GO:0034976)2.35511662
153negative regulation of TOR signaling (GO:0032007)2.35487598
154regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.34616861
155cellular response to antibiotic (GO:0071236)2.33884172
156regulation of establishment or maintenance of cell polarity (GO:0032878)2.32921566
157cilium or flagellum-dependent cell motility (GO:0001539)2.32515770
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.32348600
159regulation of histone deacetylation (GO:0031063)2.31868443
160prostate gland growth (GO:0060736)2.31747554
161necroptotic process (GO:0070266)2.30544174
162nucleobase catabolic process (GO:0046113)2.28969011
163phospholipid homeostasis (GO:0055091)2.28671907
164negative regulation of heart growth (GO:0061117)2.27235908
165negative regulation of cardiac muscle tissue growth (GO:0055022)2.27235908
166L-alpha-amino acid transmembrane transport (GO:1902475)2.26969943
167fibroblast migration (GO:0010761)2.21638535
168regulation of RNA export from nucleus (GO:0046831)2.21368835
169regulation of growth hormone secretion (GO:0060123)2.20933600
170cellular response to vitamin D (GO:0071305)2.19824462
171positive regulation of nitric-oxide synthase activity (GO:0051000)2.19661385
172regulation of protein deacetylation (GO:0090311)2.18384729
173positive regulation of B cell differentiation (GO:0045579)2.14928201
174positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.14383540
1754-hydroxyproline metabolic process (GO:0019471)2.14302554
176positive regulation of fatty acid beta-oxidation (GO:0032000)2.14237010
177ketone body metabolic process (GO:1902224)2.12717283
178protein localization to Golgi apparatus (GO:0034067)2.11921502
179glial cell proliferation (GO:0014009)2.09577809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.26461066
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.13958472
3GATA1_22025678_ChIP-Seq_K562_Human4.04338870
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.61365236
5POU3F2_20337985_ChIP-ChIP_501MEL_Human3.26201600
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07346962
7CLOCK_20551151_ChIP-Seq_293T_Human3.04430681
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90601203
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90071062
10IGF1R_20145208_ChIP-Seq_DFB_Human2.72608077
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.68546965
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65901255
13MYC_22102868_ChIP-Seq_BL_Human2.56275142
14FUS_26573619_Chip-Seq_HEK293_Human2.35112329
15TAF15_26573619_Chip-Seq_HEK293_Human2.23448512
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.22042061
17GBX2_23144817_ChIP-Seq_PC3_Human2.13388794
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05587926
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02701568
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99389118
21RUNX_20019798_ChIP-Seq_JUKART_Human1.94061665
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94052025
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90383100
24* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86617267
25ER_23166858_ChIP-Seq_MCF-7_Human1.85480683
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.84677644
27EWS_26573619_Chip-Seq_HEK293_Human1.83742811
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.80241359
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78355829
30TCF7_22412390_ChIP-Seq_EML_Mouse1.77594621
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76784805
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76759965
33FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.75508420
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75448465
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74195597
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73976947
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70155485
38SMAD4_21799915_ChIP-Seq_A2780_Human1.65682295
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64548859
40* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.64281664
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62315202
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62089082
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57703856
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57267419
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55252535
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55070144
47STAT3_23295773_ChIP-Seq_U87_Human1.54993959
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52915774
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52821546
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.51477646
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.50728403
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50541194
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49990371
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47120938
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46946243
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.46653092
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45270073
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45053843
59CBP_20019798_ChIP-Seq_JUKART_Human1.45053843
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.43858463
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42152329
62* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41912459
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39509365
64VDR_22108803_ChIP-Seq_LS180_Human1.39118129
65KDM2B_26808549_Chip-Seq_DND41_Human1.38309462
66* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36368604
67* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36368604
68BRD4_25478319_ChIP-Seq_HGPS_Human1.36117000
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35787860
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.35746108
71P300_19829295_ChIP-Seq_ESCs_Human1.34929179
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34755426
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34729665
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.34246043
75GATA3_27048872_Chip-Seq_THYMUS_Human1.32992767
76SCL_19346495_ChIP-Seq_HPC-7_Human1.32951658
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32945980
78ELK1_19687146_ChIP-ChIP_HELA_Human1.32796033
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32693817
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32605451
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32275443
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.31629992
83TCF4_23295773_ChIP-Seq_U87_Human1.31461110
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31331874
85MYB_26560356_Chip-Seq_TH2_Human1.31319468
86* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31161515
87TFEB_21752829_ChIP-Seq_HELA_Human1.30694210
88CHD1_26751641_Chip-Seq_LNCaP_Human1.30673208
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30606823
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29367651
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28824479
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.28194606
93UTX_26944678_Chip-Seq_JUKART_Human1.27587422
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27198328
95ZNF263_19887448_ChIP-Seq_K562_Human1.26517944
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26248951
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.24973735
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23990078
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23461136
100MYB_26560356_Chip-Seq_TH1_Human1.22922158
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22750871
102AHR_22903824_ChIP-Seq_MCF-7_Human1.22479237
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22479218
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21881211
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21029976
106MAF_26560356_Chip-Seq_TH1_Human1.19034526
107IRF8_27001747_Chip-Seq_BMDM_Mouse1.17749553
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17615823
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17025437
110TP53_16413492_ChIP-PET_HCT116_Human1.15566158
111P53_22387025_ChIP-Seq_ESCs_Mouse1.15148941
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14978963
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.14379425
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14188305
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14158053
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13953461
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13905569
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13643268
119SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13230176
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12848406
121PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11500714
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.11275133
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10872502
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.10832087
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.10581262
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.09999161
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09920993
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09014800
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.08939424
130WT1_19549856_ChIP-ChIP_CCG9911_Human1.08725334
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08574594
132ZNF274_21170338_ChIP-Seq_K562_Hela1.08465540
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08393380
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.08279803
135PU_27001747_Chip-Seq_BMDM_Mouse1.07599002
136* CDX2_22108803_ChIP-Seq_LS180_Human1.06889316
137GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06844210
138GATA6_25053715_ChIP-Seq_YYC3_Human1.06354294
139AR_25329375_ChIP-Seq_VCAP_Human1.05769934
140OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05116887
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05092456
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04181792
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04072489
144VDR_21846776_ChIP-Seq_THP-1_Human1.02737392
145KDM2B_26808549_Chip-Seq_JURKAT_Human1.02506394
146OCT4_18555785_Chip-Seq_ESCs_Mouse1.02430659
147SALL4_22934838_ChIP-ChIP_CD34+_Human1.01987699
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01614540
149CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00989417
150CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00972754
151* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00911207
152NMYC_18555785_Chip-Seq_ESCs_Mouse1.00292591
153TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00173574
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.99950917
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99541980
156CIITA_25753668_ChIP-Seq_RAJI_Human0.99526273
157TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98760614
158PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97596626
159BCAT_22108803_ChIP-Seq_LS180_Human0.97575269
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97226573
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95619566
162VDR_24763502_ChIP-Seq_THP-1_Human0.94987404
163FOXA1_25552417_ChIP-Seq_VCAP_Human0.94629762
164* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93800000
165SPI1_23127762_ChIP-Seq_K562_Human0.93489349
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92686017
167CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92493314
168KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92223585
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92032616
170NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91065946
171* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90494283
172GATA1_19941826_ChIP-Seq_K562_Human0.90236618
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89986799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.69895232
2MP0000569_abnormal_digit_pigmentation3.48896742
3MP0002877_abnormal_melanocyte_morpholog3.31408874
4MP0010234_abnormal_vibrissa_follicle3.28814198
5MP0003252_abnormal_bile_duct3.11185591
6MP0005248_abnormal_Harderian_gland3.07016230
7MP0003300_gastrointestinal_ulcer2.99671565
8MP0006054_spinal_hemorrhage2.89895714
9MP0002138_abnormal_hepatobiliary_system2.57278472
10MP0002166_altered_tumor_susceptibility2.55390741
11MP0002928_abnormal_bile_duct2.53945539
12MP0005365_abnormal_bile_salt2.44105337
13MP0010678_abnormal_skin_adnexa2.43632283
14MP0010352_gastrointestinal_tract_polyps2.36331207
15MP0000383_abnormal_hair_follicle2.32195448
16MP0002139_abnormal_hepatobiliary_system2.31119697
17MP0002909_abnormal_adrenal_gland2.06206649
18MP0003950_abnormal_plasma_membrane2.04779719
19MP0003787_abnormal_imprinting1.97654295
20MP0008877_abnormal_DNA_methylation1.95907232
21MP0005220_abnormal_exocrine_pancreas1.93296324
22MP0005076_abnormal_cell_differentiation1.92251141
23MP0003705_abnormal_hypodermis_morpholog1.89762160
24MP0001661_extended_life_span1.86731348
25MP0009780_abnormal_chondrocyte_physiolo1.85308717
26MP0004130_abnormal_muscle_cell1.85041582
27MP0003123_paternal_imprinting1.78586820
28MP0005360_urolithiasis1.77566817
29MP0004147_increased_porphyrin_level1.77031916
30MP0008995_early_reproductive_senescence1.73591998
31MP0000013_abnormal_adipose_tissue1.71038465
32MP0003183_abnormal_peptide_metabolism1.70822551
33MP0001944_abnormal_pancreas_morphology1.67857023
34MP0002006_tumorigenesis1.63341445
35MP0003121_genomic_imprinting1.59902835
36MP0005187_abnormal_penis_morphology1.58949531
37MP0002009_preneoplasia1.54691934
38MP0004264_abnormal_extraembryonic_tissu1.49587487
39MP0003868_abnormal_feces_composition1.48834076
40MP0005085_abnormal_gallbladder_physiolo1.48496360
41MP0005408_hypopigmentation1.47949564
42MP0000003_abnormal_adipose_tissue1.42445318
43MP0004808_abnormal_hematopoietic_stem1.39492570
44MP0002693_abnormal_pancreas_physiology1.35042116
45MP0002971_abnormal_brown_adipose1.33006894
46MP0009115_abnormal_fat_cell1.32090977
47MP0001984_abnormal_olfaction1.31569874
48MP0010307_abnormal_tumor_latency1.29049244
49MP0003303_peritoneal_inflammation1.28824036
50MP0002078_abnormal_glucose_homeostasis1.27885409
51MP0002269_muscular_atrophy1.27774499
52MP0003567_abnormal_fetal_cardiomyocyte1.26765312
53MP0002638_abnormal_pupillary_reflex1.23444879
54MP0003122_maternal_imprinting1.21947664
55MP0005645_abnormal_hypothalamus_physiol1.20538704
56MP0000609_abnormal_liver_physiology1.20419908
57MP0004145_abnormal_muscle_electrophysio1.14360731
58MP0003943_abnormal_hepatobiliary_system1.12734656
59MP0004043_abnormal_pH_regulation1.11841097
60MP0003890_abnormal_embryonic-extraembry1.11561644
61MP0009697_abnormal_copulation1.09520937
62MP0003566_abnormal_cell_adhesion1.07432868
63MP0008058_abnormal_DNA_repair1.05930610
64MP0002896_abnormal_bone_mineralization1.05918461
65MP0001873_stomach_inflammation1.03864835
66MP0005409_darkened_coat_color1.03572106
67MP0004484_altered_response_of1.03389568
68MP0010329_abnormal_lipoprotein_level1.03352304
69MP0001849_ear_inflammation1.02079220
70MP0005375_adipose_tissue_phenotype1.01939055
71MP0008961_abnormal_basal_metabolism1.00966681
72MP0004185_abnormal_adipocyte_glucose1.00905484
73MP0004134_abnormal_chest_morphology0.98883096
74MP0003221_abnormal_cardiomyocyte_apopto0.98305923
75MP0002234_abnormal_pharynx_morphology0.97467227
76MP0009672_abnormal_birth_weight0.95863817
77MP0001666_abnormal_nutrient_absorption0.95757423
78MP0004782_abnormal_surfactant_physiolog0.95640429
79MP0002088_abnormal_embryonic_growth/wei0.95182302
80MP0010630_abnormal_cardiac_muscle0.93771241
81MP0003984_embryonic_growth_retardation0.93553341
82MP0004947_skin_inflammation0.92646233
83MP0002837_dystrophic_cardiac_calcinosis0.92493490
84MP0003195_calcinosis0.90951562
85MP0001348_abnormal_lacrimal_gland0.90854231
86MP0001879_abnormal_lymphatic_vessel0.90507187
87MP0001270_distended_abdomen0.89777364
88MP0003763_abnormal_thymus_physiology0.89075906
89MP0005666_abnormal_adipose_tissue0.87421893
90MP0000537_abnormal_urethra_morphology0.86264954
91MP0000516_abnormal_urinary_system0.85846905
92MP0005367_renal/urinary_system_phenotyp0.85846905
93MP0000427_abnormal_hair_cycle0.84085821
94MP0001299_abnormal_eye_distance/0.83642342
95MP0008007_abnormal_cellular_replicative0.83057569
96MP0000733_abnormal_muscle_development0.80903905
97MP0005380_embryogenesis_phenotype0.80629809
98MP0001672_abnormal_embryogenesis/_devel0.80629809
99MP0000598_abnormal_liver_morphology0.80245373
100MP0005084_abnormal_gallbladder_morpholo0.79226765
101MP0008875_abnormal_xenobiotic_pharmacok0.78869608
102MP0003436_decreased_susceptibility_to0.78845946
103MP0003656_abnormal_erythrocyte_physiolo0.78626934
104MP0000685_abnormal_immune_system0.77838145
105MP0003091_abnormal_cell_migration0.77272251
106MP0009703_decreased_birth_body0.76419553
107MP0001727_abnormal_embryo_implantation0.76361256
108MP0009643_abnormal_urine_homeostasis0.76330923
109MP0004084_abnormal_cardiac_muscle0.76122869
110MP0005621_abnormal_cell_physiology0.75843690
111MP0004087_abnormal_muscle_fiber0.75690145
112MP0001697_abnormal_embryo_size0.74875244
113MP0002396_abnormal_hematopoietic_system0.73957552
114MP0003786_premature_aging0.73378249
115MP0000371_diluted_coat_color0.73358106
116MP0002106_abnormal_muscle_physiology0.72889496
117MP0001929_abnormal_gametogenesis0.72786308
118MP0002398_abnormal_bone_marrow0.72591557
119MP0002084_abnormal_developmental_patter0.72339264
120MP0001800_abnormal_humoral_immune0.71467763
121MP0000627_abnormal_mammary_gland0.71450029
122MP0005384_cellular_phenotype0.71436621
123MP0005319_abnormal_enzyme/_coenzyme0.70834349
124MP0002098_abnormal_vibrissa_morphology0.70674943
125MP0000465_gastrointestinal_hemorrhage0.70172285
126MP0001835_abnormal_antigen_presentation0.70153864
127MP0005334_abnormal_fat_pad0.69462343
128MP0004197_abnormal_fetal_growth/weight/0.69223403
129MP0000266_abnormal_heart_morphology0.69146649
130MP0001915_intracranial_hemorrhage0.69067869
131MP0005397_hematopoietic_system_phenotyp0.68431543
132MP0001545_abnormal_hematopoietic_system0.68431543
133MP0000703_abnormal_thymus_morphology0.67791334
134MP0002332_abnormal_exercise_endurance0.67759986
135MP0001191_abnormal_skin_condition0.67116278
136MP0003718_maternal_effect0.65910664
137MP0002102_abnormal_ear_morphology0.65551682
138MP0005451_abnormal_body_composition0.65448657
139MP0003385_abnormal_body_wall0.65067275
140MP0002970_abnormal_white_adipose0.63587086
141MP0000653_abnormal_sex_gland0.62572785
142MP0004233_abnormal_muscle_weight0.62412979
143MP0001186_pigmentation_phenotype0.62286562
144MP0005083_abnormal_biliary_tract0.62005472
145MP0003172_abnormal_lysosome_physiology0.61833980
146MP0005253_abnormal_eye_physiology0.61221130
147MP0005386_behavior/neurological_phenoty0.60283055
148MP0004924_abnormal_behavior0.60283055
149MP0010368_abnormal_lymphatic_system0.59707445
150MP0002118_abnormal_lipid_homeostasis0.59607697
151MP0002086_abnormal_extraembryonic_tissu0.59102076
152MP0001845_abnormal_inflammatory_respons0.59013001
153MP0002925_abnormal_cardiovascular_devel0.58937201

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)4.16035780
2Thyroid carcinoma (HP:0002890)4.07499225
3Ketoacidosis (HP:0001993)3.66749482
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.52419734
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.52419734
6Hepatoblastoma (HP:0002884)3.46068995
7Deep philtrum (HP:0002002)3.43953329
8Subacute progressive viral hepatitis (HP:0006572)3.42656262
9Hypoglycemic coma (HP:0001325)3.40783870
10Curly hair (HP:0002212)3.39241621
11Termporal pattern (HP:0011008)3.24937561
12Insidious onset (HP:0003587)3.24937561
13Hypoglycemic seizures (HP:0002173)3.22989493
14Pheochromocytoma (HP:0002666)3.20665933
15Cystic hygroma (HP:0000476)3.10599226
16Exercise-induced myalgia (HP:0003738)3.02984154
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.00710962
18Hyperglycemia (HP:0003074)2.86243228
19Enlarged penis (HP:0000040)2.82877062
20Abnormality of the corticospinal tract (HP:0002492)2.81233931
21Neuroendocrine neoplasm (HP:0100634)2.68204319
22Proximal tubulopathy (HP:0000114)2.66837488
23Lymphangioma (HP:0100764)2.62223737
24Poor coordination (HP:0002370)2.61172424
25Congenital primary aphakia (HP:0007707)2.60221467
26Ketosis (HP:0001946)2.58166966
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.55506070
28Short tibia (HP:0005736)2.53783938
29Overlapping toe (HP:0001845)2.53397302
30Abnormality of the fingertips (HP:0001211)2.50444314
31Gait imbalance (HP:0002141)2.48909578
32Hyperinsulinemic hypoglycemia (HP:0000825)2.47519344
33Abnormality of the left ventricular outflow tract (HP:0011103)2.44771496
34Subaortic stenosis (HP:0001682)2.44771496
35Long toe (HP:0010511)2.44124912
36Aortic aneurysm (HP:0004942)2.42335628
37Hip dysplasia (HP:0001385)2.40350695
38Exostoses (HP:0100777)2.39868630
39Cerebral aneurysm (HP:0004944)2.39862507
40Hyperkalemia (HP:0002153)2.37772575
41Tubulointerstitial nephritis (HP:0001970)2.35676446
42Symptomatic seizures (HP:0011145)2.35501206
43Hematochezia (HP:0002573)2.35185554
44Cortical dysplasia (HP:0002539)2.34521130
45Widely spaced teeth (HP:0000687)2.34370381
46Breast carcinoma (HP:0003002)2.34179923
47Nephrogenic diabetes insipidus (HP:0009806)2.30920089
48Abnormality of endocrine pancreas physiology (HP:0012093)2.30748718
49Abnormality of the pancreatic islet cells (HP:0006476)2.30748718
50Fair hair (HP:0002286)2.28880438
51Myoglobinuria (HP:0002913)2.28313748
52Medial flaring of the eyebrow (HP:0010747)2.27839848
53Insulin-resistant diabetes mellitus (HP:0000831)2.25136152
54Disinhibition (HP:0000734)2.24759991
55Agitation (HP:0000713)2.21642880
56Cutaneous melanoma (HP:0012056)2.21557897
57Striae distensae (HP:0001065)2.18035910
58Genital tract atresia (HP:0001827)2.16918029
59Renal cortical cysts (HP:0000803)2.15543435
60Neoplasm of the adrenal cortex (HP:0100641)2.15135785
61Acute myeloid leukemia (HP:0004808)2.11775883
62Drooling (HP:0002307)2.11149665
63Excessive salivation (HP:0003781)2.11149665
64Unilateral renal agenesis (HP:0000122)2.10320106
65Papilledema (HP:0001085)2.09051637
66Abnormal biliary tract morphology (HP:0012440)2.06305410
67Volvulus (HP:0002580)2.04902748
68Fatigue (HP:0012378)2.04839391
69Capillary hemangiomas (HP:0005306)2.04789817
70Pancreatic islet-cell hyperplasia (HP:0004510)2.04258201
71Hepatocellular carcinoma (HP:0001402)2.02901027
72Inappropriate behavior (HP:0000719)2.02526248
73Large earlobe (HP:0009748)2.02045966
74Medulloblastoma (HP:0002885)2.01488806
75Heterotopia (HP:0002282)2.01213882
76Neoplasm of the thyroid gland (HP:0100031)2.01171729
77Abnormality of the intrinsic pathway (HP:0010989)2.00745526
78Abnormality of the hip-girdle musculature (HP:0001445)2.00574966
79Abnormality of the musculature of the pelvis (HP:0001469)2.00574966
80Hyperventilation (HP:0002883)2.00444394
81Blue irides (HP:0000635)2.00427008
82Chronic hepatic failure (HP:0100626)1.99097663
83Aneurysm (HP:0002617)1.98605961
84Sandal gap (HP:0001852)1.98100294
85Viral hepatitis (HP:0006562)1.97244020
86Bladder neoplasm (HP:0009725)1.96695167
87Bladder carcinoma (HP:0002862)1.96695167
88Cubitus valgus (HP:0002967)1.96021312
89Abnormality of the common coagulation pathway (HP:0010990)1.95176453
90Papillary thyroid carcinoma (HP:0002895)1.93628757
91Deep venous thrombosis (HP:0002625)1.93319978
92Epidermoid cyst (HP:0200040)1.92885322
93Median cleft lip (HP:0000161)1.92500773
94Hypoplasia of the thymus (HP:0000778)1.91013974
95Neoplasm of the small intestine (HP:0100833)1.90793221
96Entropion (HP:0000621)1.90653833
97Open mouth (HP:0000194)1.90284319
98Severe short stature (HP:0003510)1.90103743
99Submucous cleft hard palate (HP:0000176)1.88502648
100Neoplasm of the adrenal gland (HP:0100631)1.87174679
101Hypoplastic ischia (HP:0003175)1.86056515
102Vaginal atresia (HP:0000148)1.85931847
103Abnormality of the periventricular white matter (HP:0002518)1.85763366
104Neoplasm of the heart (HP:0100544)1.84205431
105Thin bony cortex (HP:0002753)1.84190972
106Narrow palate (HP:0000189)1.83847640
107Generalized hypopigmentation of hair (HP:0011358)1.83812945
108Abnormality of the ischium (HP:0003174)1.83099152
109Thoracolumbar scoliosis (HP:0002944)1.82578940
110Abnormality of the renal cortex (HP:0011035)1.80857301
111Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.79971410
112Broad palm (HP:0001169)1.79493341
113Micronodular cirrhosis (HP:0001413)1.78267455
114Asymmetry of the thorax (HP:0001555)1.78107304
115Thrombocytosis (HP:0001894)1.77658154
116Pulmonic stenosis (HP:0001642)1.77228183
117Central scotoma (HP:0000603)1.76137433
118Gonadotropin excess (HP:0000837)1.75896786
119Abnormal pancreas size (HP:0012094)1.75538421
120Hamartoma (HP:0010566)1.75372527
121Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74606159
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74098162
123Biliary tract neoplasm (HP:0100574)1.73850834
124Frequent falls (HP:0002359)1.72135612
125Hyperacusis (HP:0010780)1.71514467
126Osteomalacia (HP:0002749)1.70988962
127Colitis (HP:0002583)1.70929293
128Long clavicles (HP:0000890)1.70565719
129Spinal cord lesions (HP:0100561)1.69526934
130Syringomyelia (HP:0003396)1.69526934
131Obsessive-compulsive behavior (HP:0000722)1.68959093
132Hypobetalipoproteinemia (HP:0003563)1.68308036
133Rectal prolapse (HP:0002035)1.67767629
134Chorioretinal atrophy (HP:0000533)1.67684592
135Broad alveolar ridges (HP:0000187)1.67506951
136Cutis marmorata (HP:0000965)1.67442278
137Urinary urgency (HP:0000012)1.66460880
138Flat acetabular roof (HP:0003180)1.65770594
139Thick eyebrow (HP:0000574)1.65651103
140Abnormality of the gastric mucosa (HP:0004295)1.65375038
141Intrahepatic cholestasis (HP:0001406)1.64677510
142Hypoplastic labia majora (HP:0000059)1.64447245
143Pelvic girdle muscle weakness (HP:0003749)1.63779927
144Urinary glycosaminoglycan excretion (HP:0003541)1.63524935
145Mucopolysacchariduria (HP:0008155)1.63524935
146Neoplasm of the oral cavity (HP:0100649)1.62985933
147Hypopigmentation of the fundus (HP:0007894)1.62759334
148Aplasia/Hypoplasia of the lens (HP:0008063)1.62360590
149Absent frontal sinuses (HP:0002688)1.62002548
150Truncal obesity (HP:0001956)1.61921075
151Prominent nasal bridge (HP:0000426)1.61806084
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61739834
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61739834
154Abnormality of polysaccharide metabolism (HP:0011012)1.61739834
155Freckling (HP:0001480)1.60891467
156Verrucae (HP:0200043)1.60426489
157Papilloma (HP:0012740)1.60426489
158Skin nodule (HP:0200036)1.60160786
159Thickened nuchal skin fold (HP:0000474)1.60157675
160Transitional cell carcinoma of the bladder (HP:0006740)1.60021150
161Rimmed vacuoles (HP:0003805)1.59222456
162Mitral stenosis (HP:0001718)1.59085012
163Dysmetric saccades (HP:0000641)1.59018915
164Abnormality of aromatic amino acid family metabolism (HP:0004338)1.58761603
165Degeneration of anterior horn cells (HP:0002398)1.57954315
166Abnormality of the anterior horn cell (HP:0006802)1.57954315
167Hemangiomatosis (HP:0007461)1.57664332
168Short 4th metacarpal (HP:0010044)1.57424380
169Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.57424380
170Absent eyebrow (HP:0002223)1.57116817
171Periodontitis (HP:0000704)1.56922762
172Coarse hair (HP:0002208)1.56727628
173Gaze-evoked nystagmus (HP:0000640)1.56641790
174Uterine leiomyosarcoma (HP:0002891)1.55842460
175Leiomyosarcoma (HP:0100243)1.55842460
176Elfin facies (HP:0004428)1.55457524
177Recurrent viral infections (HP:0004429)1.54330816
178Conjugated hyperbilirubinemia (HP:0002908)1.54023329
179Hamartoma of the eye (HP:0010568)1.53667091
180Bowel diverticulosis (HP:0005222)1.53380820
181Menstrual irregularities (HP:0000858)1.52925800
182Conjunctival hamartoma (HP:0100780)1.52423566
183Myocardial infarction (HP:0001658)1.51816001
184Mitral valve prolapse (HP:0001634)1.51592358
185Abnormality of oral frenula (HP:0000190)1.51419916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.58883250
2PKN23.43921385
3FRK3.04730729
4MAP3K102.96120131
5EIF2AK32.77324751
6TRIB32.74072132
7ERN12.57752617
8BCR2.43505785
9BRSK22.36316312
10INSRR2.36030884
11WNK32.17600020
12SIK12.09284396
13ACVR1B2.05004350
14TAOK32.01771886
15LATS12.01760457
16EEF2K1.88419638
17SCYL21.85147025
18PTK61.76531490
19CDK121.69190444
20TTN1.66218742
21STK38L1.63286296
22EIF2AK11.59729455
23FLT31.58986936
24ERBB31.56436120
25FGFR31.55910085
26JAK11.54565677
27FGFR21.53853607
28JAK31.53217537
29TYK21.52917931
30CAMK1D1.49386114
31OBSCN1.48360349
32MST41.47436799
33NEK61.45357999
34SRPK11.42989708
35TGFBR11.40470657
36HIPK21.36601590
37TGFBR21.31216737
38SIK21.30638350
39CAMK1G1.29634446
40RIPK11.29493908
41MAP3K21.29017807
42RET1.28632000
43PDGFRA1.27433823
44BMPR1B1.24104856
45CDK61.23132113
46FGFR41.18144583
47BRD41.15069775
48PRKD31.14519829
49DYRK1B1.11163154
50STK381.10865206
51PRKCH1.09766909
52MARK11.09548349
53LRRK21.08890642
54FER1.07331902
55TRPM71.05933322
56EPHA31.05338902
57YES11.03052357
58PIK3CA1.03042896
59JAK21.01496454
60CDK91.00939643
61PINK10.97683200
62PAK30.96638878
63STK100.96569435
64CAMKK20.91315425
65SIK30.87830619
66PASK0.86819731
67MAP3K140.86450735
68MTOR0.85694637
69NEK90.85089172
70MAP3K50.83420618
71SGK4940.83274386
72SGK2230.83274386
73STK30.82985972
74BMPR20.82833004
75MELK0.79785190
76KSR10.79206179
77SGK30.78710928
78PDK20.77832021
79MAP3K70.77600866
80MAPK110.76955135
81MAP2K70.74157780
82MAP3K60.73289891
83NTRK30.72787428
84NUAK10.72480547
85DYRK30.71398039
86WEE10.69765882
87MAPKAPK30.66721466
88PDGFRB0.65159263
89CAMK40.65147507
90MAP2K40.64591161
91PIM20.63788096
92ATM0.63452817
93ITK0.63350245
94TBK10.63246059
95MAP4K10.63131524
96PRKAA10.62506660
97PHKG20.61032016
98PHKG10.61032016
99KSR20.60460370
100LMTK20.60073820
101CAMKK10.55782123
102RAF10.52025870
103RPS6KB10.51556674
104CDC70.51169031
105PRKCE0.50347042
106TNIK0.50252264
107EIF2AK20.49721340
108STK240.49230153
109CSNK1G10.48846322
110CDK40.48729707
111EGFR0.48624775
112WNK10.47879182
113CSNK1A1L0.47210866
114FGFR10.47143980
115MAPK130.47130195
116PLK20.46812231
117SGK10.45531587
118DYRK1A0.45517796
119CLK10.44922594
120CASK0.44545763
121RPS6KA40.44516713
122MKNK10.43521978
123MARK20.43113279
124CHUK0.43029720
125CSNK1G30.42936106
126PRKAA20.42676376
127CSNK1G20.42632153
128MAP3K130.40132555
129NLK0.39328570
130RPS6KA20.38828926
131CSNK1D0.38826093
132SYK0.38721154
133ATR0.38667277
134MAPK100.38531992
135RPS6KB20.38496653
136GRK60.38027009
137PRKD10.38026748
138PDK10.37785508
139IRAK10.37493949
140IRAK20.37236041
141MAPK90.37200856
142MAP3K30.36977362
143MAP3K40.36845073
144SGK20.36765830
145PIK3CG0.35254288

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.94794063
2Nitrogen metabolism_Homo sapiens_hsa009102.05929328
3Insulin resistance_Homo sapiens_hsa049312.05183773
4Inositol phosphate metabolism_Homo sapiens_hsa005622.02696507
5Lysine degradation_Homo sapiens_hsa003101.87551267
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86578814
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.84864386
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.84328784
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77188374
10Type II diabetes mellitus_Homo sapiens_hsa049301.71136928
11mTOR signaling pathway_Homo sapiens_hsa041501.70467132
12Fatty acid degradation_Homo sapiens_hsa000711.66634900
13Endometrial cancer_Homo sapiens_hsa052131.64207670
14Chronic myeloid leukemia_Homo sapiens_hsa052201.63539295
15Protein export_Homo sapiens_hsa030601.58062584
16Non-homologous end-joining_Homo sapiens_hsa034501.52711416
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51599394
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44848002
19Colorectal cancer_Homo sapiens_hsa052101.44576752
20Caffeine metabolism_Homo sapiens_hsa002321.40355613
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38708193
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38041777
23B cell receptor signaling pathway_Homo sapiens_hsa046621.37815554
24Pancreatic cancer_Homo sapiens_hsa052121.33147082
25Fatty acid biosynthesis_Homo sapiens_hsa000611.29284999
26Insulin signaling pathway_Homo sapiens_hsa049101.28452527
27Tryptophan metabolism_Homo sapiens_hsa003801.24054624
28Glucagon signaling pathway_Homo sapiens_hsa049221.22801022
29ErbB signaling pathway_Homo sapiens_hsa040121.22366147
30Selenocompound metabolism_Homo sapiens_hsa004501.20437456
31Sulfur metabolism_Homo sapiens_hsa009201.19452472
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.19344957
33Choline metabolism in cancer_Homo sapiens_hsa052311.18954915
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.17214098
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16615678
36mRNA surveillance pathway_Homo sapiens_hsa030151.15992555
37Prolactin signaling pathway_Homo sapiens_hsa049171.12493858
38Non-small cell lung cancer_Homo sapiens_hsa052231.11762555
39RNA degradation_Homo sapiens_hsa030181.10295373
40N-Glycan biosynthesis_Homo sapiens_hsa005101.08783654
41AMPK signaling pathway_Homo sapiens_hsa041521.08446480
42Adherens junction_Homo sapiens_hsa045201.05875301
43Basal transcription factors_Homo sapiens_hsa030221.04436643
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.03612340
45Osteoclast differentiation_Homo sapiens_hsa043801.03260784
46FoxO signaling pathway_Homo sapiens_hsa040681.02717562
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.01788490
48p53 signaling pathway_Homo sapiens_hsa041151.00284075
49Viral myocarditis_Homo sapiens_hsa054160.97029113
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95539977
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95369158
52Regulation of autophagy_Homo sapiens_hsa041400.95237956
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94527193
54TNF signaling pathway_Homo sapiens_hsa046680.94130827
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94120472
56RNA transport_Homo sapiens_hsa030130.93702511
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93276573
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92857659
59Fanconi anemia pathway_Homo sapiens_hsa034600.92822780
60TGF-beta signaling pathway_Homo sapiens_hsa043500.92194941
61Toxoplasmosis_Homo sapiens_hsa051450.91083563
62Glioma_Homo sapiens_hsa052140.90847532
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90786294
64Starch and sucrose metabolism_Homo sapiens_hsa005000.88946060
65Circadian rhythm_Homo sapiens_hsa047100.88140286
66Acute myeloid leukemia_Homo sapiens_hsa052210.87075519
67Long-term depression_Homo sapiens_hsa047300.85973072
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85943632
69Proteoglycans in cancer_Homo sapiens_hsa052050.85514553
70Hepatitis B_Homo sapiens_hsa051610.85213642
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.82247103
72Leishmaniasis_Homo sapiens_hsa051400.81519927
73Oocyte meiosis_Homo sapiens_hsa041140.80925465
74Dorso-ventral axis formation_Homo sapiens_hsa043200.80799220
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80366673
76Insulin secretion_Homo sapiens_hsa049110.80275592
77Propanoate metabolism_Homo sapiens_hsa006400.79153762
78T cell receptor signaling pathway_Homo sapiens_hsa046600.77145994
79Complement and coagulation cascades_Homo sapiens_hsa046100.76656138
80Small cell lung cancer_Homo sapiens_hsa052220.76193650
81Arginine biosynthesis_Homo sapiens_hsa002200.75738029
82MicroRNAs in cancer_Homo sapiens_hsa052060.75378359
83ABC transporters_Homo sapiens_hsa020100.74293449
84Focal adhesion_Homo sapiens_hsa045100.73985407
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73897156
86PPAR signaling pathway_Homo sapiens_hsa033200.72746417
87Prostate cancer_Homo sapiens_hsa052150.72494484
88Antigen processing and presentation_Homo sapiens_hsa046120.71947646
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70680242
90Apoptosis_Homo sapiens_hsa042100.69643240
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69586347
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69500590
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68436746
94Fatty acid metabolism_Homo sapiens_hsa012120.67929263
95Bile secretion_Homo sapiens_hsa049760.67273621
96Butanoate metabolism_Homo sapiens_hsa006500.66254319
97Thyroid hormone synthesis_Homo sapiens_hsa049180.65903027
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.65322780
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65285958
100VEGF signaling pathway_Homo sapiens_hsa043700.64949055
101Platelet activation_Homo sapiens_hsa046110.64386470
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.64213005
103Cell cycle_Homo sapiens_hsa041100.63794463
104Sphingolipid metabolism_Homo sapiens_hsa006000.63734025
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63063420
106Estrogen signaling pathway_Homo sapiens_hsa049150.62864895
107Pyruvate metabolism_Homo sapiens_hsa006200.62623883
108Renal cell carcinoma_Homo sapiens_hsa052110.62458573
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62416836
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60731474
111Primary immunodeficiency_Homo sapiens_hsa053400.59483276
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58935900
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58706039
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.58516173
115Long-term potentiation_Homo sapiens_hsa047200.56885365
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56241972
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55834575
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55113229
119Peroxisome_Homo sapiens_hsa041460.54982540
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54965019
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54768596
122HTLV-I infection_Homo sapiens_hsa051660.53969990
123Melanoma_Homo sapiens_hsa052180.53860590
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53580151
125Viral carcinogenesis_Homo sapiens_hsa052030.52899737
126Amoebiasis_Homo sapiens_hsa051460.51887500
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51014007
128Alcoholism_Homo sapiens_hsa050340.50734965
129Renin-angiotensin system_Homo sapiens_hsa046140.50555522
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50436205
131Nucleotide excision repair_Homo sapiens_hsa034200.50311940
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50027104
133Renin secretion_Homo sapiens_hsa049240.49927920
134Steroid biosynthesis_Homo sapiens_hsa001000.49743108
135Thyroid cancer_Homo sapiens_hsa052160.49677093
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48864108
137Legionellosis_Homo sapiens_hsa051340.47115621
138Influenza A_Homo sapiens_hsa051640.46527713
139Ether lipid metabolism_Homo sapiens_hsa005650.43002495
140HIF-1 signaling pathway_Homo sapiens_hsa040660.42392213
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39819724
142Ovarian steroidogenesis_Homo sapiens_hsa049130.38694317
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37342891

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