

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 4.91964566 |
| 2 | DNA unwinding involved in DNA replication (GO:0006268) | 4.89725394 |
| 3 | nuclear pore organization (GO:0006999) | 4.89345215 |
| 4 | pre-miRNA processing (GO:0031054) | 4.61169130 |
| 5 | regulation of RNA export from nucleus (GO:0046831) | 4.49103828 |
| 6 | dosage compensation (GO:0007549) | 4.45338464 |
| 7 | COPI coating of Golgi vesicle (GO:0048205) | 4.37795808 |
| 8 | Golgi transport vesicle coating (GO:0048200) | 4.37795808 |
| 9 | regulation of translational fidelity (GO:0006450) | 4.36274055 |
| 10 | mitotic sister chromatid cohesion (GO:0007064) | 4.33556416 |
| 11 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.31769284 |
| 12 | regulation of sister chromatid cohesion (GO:0007063) | 4.20491315 |
| 13 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 4.10116576 |
| 14 | protein localization to kinetochore (GO:0034501) | 4.08345978 |
| 15 | embryonic process involved in female pregnancy (GO:0060136) | 4.01930323 |
| 16 | sister chromatid segregation (GO:0000819) | 3.95791426 |
| 17 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.93658199 |
| 18 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.93658199 |
| 19 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.93658199 |
| 20 | mitotic nuclear envelope disassembly (GO:0007077) | 3.90941049 |
| 21 | establishment of apical/basal cell polarity (GO:0035089) | 3.86877767 |
| 22 | DNA topological change (GO:0006265) | 3.76929054 |
| 23 | DNA duplex unwinding (GO:0032508) | 3.75708101 |
| 24 | nuclear envelope disassembly (GO:0051081) | 3.74107398 |
| 25 | membrane disassembly (GO:0030397) | 3.74107398 |
| 26 | DNA geometric change (GO:0032392) | 3.73908114 |
| 27 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.73898450 |
| 28 | heterochromatin organization (GO:0070828) | 3.73240714 |
| 29 | establishment of integrated proviral latency (GO:0075713) | 3.71635543 |
| 30 | negative regulation of RNA splicing (GO:0033119) | 3.63968210 |
| 31 | positive regulation of chromosome segregation (GO:0051984) | 3.63857564 |
| 32 | negative regulation of mRNA processing (GO:0050686) | 3.58960046 |
| 33 | mitotic sister chromatid segregation (GO:0000070) | 3.56512928 |
| 34 | negative regulation of histone methylation (GO:0031061) | 3.55734012 |
| 35 | mitotic G1 DNA damage checkpoint (GO:0031571) | 3.52670476 |
| 36 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.52155431 |
| 37 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.52155431 |
| 38 | pore complex assembly (GO:0046931) | 3.51053400 |
| 39 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.50531380 |
| 40 | regulation of histone H3-K9 methylation (GO:0051570) | 3.45799054 |
| 41 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.42704985 |
| 42 | non-recombinational repair (GO:0000726) | 3.42704985 |
| 43 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.38192683 |
| 44 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.37507207 |
| 45 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.37507207 |
| 46 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 3.34886387 |
| 47 | establishment of monopolar cell polarity (GO:0061162) | 3.34886387 |
| 48 | formation of translation preinitiation complex (GO:0001731) | 3.34431867 |
| 49 | mitotic chromosome condensation (GO:0007076) | 3.32610534 |
| 50 | proline biosynthetic process (GO:0006561) | 3.30906961 |
| 51 | negative regulation of mRNA metabolic process (GO:1903312) | 3.29742498 |
| 52 | protein localization to chromosome, centromeric region (GO:0071459) | 3.29326544 |
| 53 | regulation of gene silencing by RNA (GO:0060966) | 3.27522260 |
| 54 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.27522260 |
| 55 | regulation of gene silencing by miRNA (GO:0060964) | 3.27522260 |
| 56 | chromatin assembly (GO:0031497) | 3.26913002 |
| 57 | replication fork processing (GO:0031297) | 3.26467684 |
| 58 | kinetochore organization (GO:0051383) | 3.22984889 |
| 59 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.20206827 |
| 60 | G1 DNA damage checkpoint (GO:0044783) | 3.18542734 |
| 61 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.14642656 |
| 62 | nucleosome disassembly (GO:0006337) | 3.13408586 |
| 63 | protein-DNA complex disassembly (GO:0032986) | 3.13408586 |
| 64 | regulation of DNA damage checkpoint (GO:2000001) | 3.13229401 |
| 65 | nuclear envelope organization (GO:0006998) | 3.12040622 |
| 66 | mRNA cleavage (GO:0006379) | 3.11559010 |
| 67 | protein complex localization (GO:0031503) | 3.05168816 |
| 68 | mRNA transport (GO:0051028) | 3.04113838 |
| 69 | regulation of spindle organization (GO:0090224) | 3.03171520 |
| 70 | protein export from nucleus (GO:0006611) | 3.01932137 |
| 71 | RNA stabilization (GO:0043489) | 3.01403459 |
| 72 | mRNA stabilization (GO:0048255) | 3.01403459 |
| 73 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.01019790 |
| 74 | DNA strand elongation (GO:0022616) | 3.00672895 |
| 75 | cellular protein complex localization (GO:0034629) | 3.00398570 |
| 76 | paraxial mesoderm development (GO:0048339) | 3.00159076 |
| 77 | chromosome condensation (GO:0030261) | 2.99289711 |
| 78 | mitotic G1/S transition checkpoint (GO:0044819) | 2.98287254 |
| 79 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.97467907 |
| 80 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.96360506 |
| 81 | regulation of centrosome cycle (GO:0046605) | 2.94980243 |
| 82 | DNA conformation change (GO:0071103) | 2.92831060 |
| 83 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.92744494 |
| 84 | DNA replication initiation (GO:0006270) | 2.91838962 |
| 85 | histone H2A monoubiquitination (GO:0035518) | 2.90831570 |
| 86 | trophectodermal cell differentiation (GO:0001829) | 2.89703228 |
| 87 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.89611468 |
| 88 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.89088386 |
| 89 | metaphase plate congression (GO:0051310) | 2.88696416 |
| 90 | regulation of translational termination (GO:0006449) | 2.86783153 |
| 91 | IMP biosynthetic process (GO:0006188) | 2.86535336 |
| 92 | ATP-dependent chromatin remodeling (GO:0043044) | 2.85979735 |
| 93 | histone H2B ubiquitination (GO:0033523) | 2.85257664 |
| 94 | polarized epithelial cell differentiation (GO:0030859) | 2.84990697 |
| 95 | meiotic chromosome segregation (GO:0045132) | 2.84938330 |
| 96 | negative regulation of DNA repair (GO:0045738) | 2.83467291 |
| 97 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.82324613 |
| 98 | regulation of centriole replication (GO:0046599) | 2.82225496 |
| 99 | regulation of chromosome segregation (GO:0051983) | 2.81015139 |
| 100 | regulation of double-strand break repair (GO:2000779) | 2.80606199 |
| 101 | peptidyl-lysine dimethylation (GO:0018027) | 2.80343668 |
| 102 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.80234904 |
| 103 | negative regulation of chromosome segregation (GO:0051985) | 2.80104248 |
| 104 | base-excision repair (GO:0006284) | 2.79692929 |
| 105 | regulation of centrosome duplication (GO:0010824) | 2.79563052 |
| 106 | mitotic metaphase plate congression (GO:0007080) | 2.79114720 |
| 107 | termination of RNA polymerase II transcription (GO:0006369) | 2.78936675 |
| 108 | mitotic recombination (GO:0006312) | 2.78714067 |
| 109 | regulation of mitotic spindle organization (GO:0060236) | 2.76971069 |
| 110 | protein localization to chromosome (GO:0034502) | 2.76409479 |
| 111 | hippo signaling (GO:0035329) | 2.76058786 |
| 112 | translesion synthesis (GO:0019985) | 2.75072122 |
| 113 | RNA transport (GO:0050658) | 2.74543327 |
| 114 | establishment of RNA localization (GO:0051236) | 2.74543327 |
| 115 | nucleic acid transport (GO:0050657) | 2.74543327 |
| 116 | regulation of stem cell maintenance (GO:2000036) | 2.74209440 |
| 117 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.73233490 |
| 118 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.72808280 |
| 119 | mitotic cytokinesis (GO:0000281) | 2.72790294 |
| 120 | NLS-bearing protein import into nucleus (GO:0006607) | 2.70766970 |
| 121 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.70729002 |
| 122 | establishment of chromosome localization (GO:0051303) | 2.68443990 |
| 123 | establishment of viral latency (GO:0019043) | 2.64481543 |
| 124 | DNA packaging (GO:0006323) | 2.63977894 |
| 125 | COPII vesicle coating (GO:0048208) | 2.62551191 |
| 126 | vesicle coating (GO:0006901) | 2.62303883 |
| 127 | protein retention in ER lumen (GO:0006621) | 2.61809485 |
| 128 | ribosome assembly (GO:0042255) | 2.58051892 |
| 129 | DNA ligation (GO:0006266) | 2.57671403 |
| 130 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.56652935 |
| 131 | mitotic spindle organization (GO:0007052) | 2.54478113 |
| 132 | peptidyl-arginine methylation (GO:0018216) | 2.53053320 |
| 133 | peptidyl-arginine N-methylation (GO:0035246) | 2.53053320 |
| 134 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.51575062 |
| 135 | DNA synthesis involved in DNA repair (GO:0000731) | 2.50535523 |
| 136 | regulation of sister chromatid segregation (GO:0033045) | 2.48883473 |
| 137 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.48883473 |
| 138 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.48883473 |
| 139 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.48681962 |
| 140 | mitotic spindle checkpoint (GO:0071174) | 2.46868750 |
| 141 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.46773027 |
| 142 | spindle checkpoint (GO:0031577) | 2.45512744 |
| 143 | chromosome segregation (GO:0007059) | 2.42876720 |
| 144 | mitotic spindle assembly checkpoint (GO:0007094) | 2.42074236 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.02847247 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.24916029 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.58015974 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.55812520 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.31884943 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.87584292 |
| 7 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.72895630 |
| 8 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.72002763 |
| 9 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.68434225 |
| 10 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.66728099 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.55150741 |
| 12 | * MYC_22102868_ChIP-Seq_BL_Human | 2.53473515 |
| 13 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 2.49930244 |
| 14 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.35819331 |
| 15 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.35625811 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.34055479 |
| 17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.22440196 |
| 18 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.20427791 |
| 19 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.13143384 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.97585561 |
| 21 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.94230899 |
| 22 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.90999749 |
| 23 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.87022693 |
| 24 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.83199761 |
| 25 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.77675658 |
| 26 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.75758828 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.69761310 |
| 28 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.64885385 |
| 29 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.64394564 |
| 30 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.64356898 |
| 31 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.63293180 |
| 32 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.63293180 |
| 33 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.63293180 |
| 34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.62620286 |
| 35 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.61313624 |
| 36 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.60863897 |
| 37 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.59557194 |
| 38 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.59389694 |
| 39 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.59336903 |
| 40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.57837360 |
| 41 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.57693315 |
| 42 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.56440760 |
| 43 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.54912820 |
| 44 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.54120055 |
| 45 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.53778005 |
| 46 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.49445520 |
| 47 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.48871014 |
| 48 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.47911139 |
| 49 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.47766562 |
| 50 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.46737587 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.43765561 |
| 52 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.42058314 |
| 53 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.41810298 |
| 54 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.41187744 |
| 55 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.40347168 |
| 56 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.39089818 |
| 57 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.39006551 |
| 58 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.38561088 |
| 59 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.38449250 |
| 60 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.34904889 |
| 61 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.34341781 |
| 62 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.32505106 |
| 63 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 1.32134362 |
| 64 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.29910747 |
| 65 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.29731553 |
| 66 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.29591700 |
| 67 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.28103574 |
| 68 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.27688858 |
| 69 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.27629282 |
| 70 | * ZNF263_19887448_ChIP-Seq_K562_Human | 1.26953672 |
| 71 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.26723496 |
| 72 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 1.26656380 |
| 73 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.25934699 |
| 74 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.25091421 |
| 75 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23843993 |
| 76 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.21681488 |
| 77 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.21468686 |
| 78 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.21459952 |
| 79 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.20660376 |
| 80 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.19740313 |
| 81 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.19529186 |
| 82 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.18837876 |
| 83 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.18523099 |
| 84 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.18227067 |
| 85 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.18188842 |
| 86 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.17624614 |
| 87 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.15798155 |
| 88 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.15346288 |
| 89 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.15286134 |
| 90 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.12353018 |
| 91 | * KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11984602 |
| 92 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.11605373 |
| 93 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10650005 |
| 94 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.09692917 |
| 95 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.08899431 |
| 96 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.07187200 |
| 97 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06022156 |
| 98 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.05775237 |
| 99 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.05506515 |
| 100 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.04419599 |
| 101 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.01746442 |
| 102 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01367705 |
| 103 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.00674087 |
| 104 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.00591245 |
| 105 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.99429736 |
| 106 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.97773738 |
| 107 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.97750447 |
| 108 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.96205831 |
| 109 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.95985596 |
| 110 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.95155420 |
| 111 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.94928607 |
| 112 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.94286596 |
| 113 | ATF3_27146783_Chip-Seq_COLON_Human | 0.93588120 |
| 114 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.93040968 |
| 115 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.91866597 |
| 116 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90590993 |
| 117 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.90452864 |
| 118 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.90281019 |
| 119 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.88843346 |
| 120 | * VDR_23849224_ChIP-Seq_CD4+_Human | 0.87666777 |
| 121 | * GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.87586286 |
| 122 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.84741552 |
| 123 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.79298737 |
| 124 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.78959151 |
| 125 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.78891762 |
| 126 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.78891762 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 3.71341010 |
| 2 | MP0010352_gastrointestinal_tract_polyps | 3.38371615 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.17803198 |
| 4 | MP0003705_abnormal_hypodermis_morpholog | 2.92058961 |
| 5 | MP0005076_abnormal_cell_differentiation | 2.82648321 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.79044553 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.77659430 |
| 8 | MP0003077_abnormal_cell_cycle | 2.53556524 |
| 9 | MP0010030_abnormal_orbit_morphology | 2.50903268 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.47165539 |
| 11 | MP0009278_abnormal_bone_marrow | 2.25351042 |
| 12 | MP0003123_paternal_imprinting | 2.21516485 |
| 13 | MP0010307_abnormal_tumor_latency | 2.20633186 |
| 14 | MP0000537_abnormal_urethra_morphology | 2.18872764 |
| 15 | MP0001730_embryonic_growth_arrest | 2.16625921 |
| 16 | MP0002084_abnormal_developmental_patter | 2.16344405 |
| 17 | * MP0004197_abnormal_fetal_growth/weight/ | 2.06674359 |
| 18 | MP0003890_abnormal_embryonic-extraembry | 2.05807601 |
| 19 | MP0009053_abnormal_anal_canal | 2.05589059 |
| 20 | MP0003567_abnormal_fetal_cardiomyocyte | 2.03213926 |
| 21 | MP0000350_abnormal_cell_proliferation | 2.00099504 |
| 22 | MP0002086_abnormal_extraembryonic_tissu | 1.95251299 |
| 23 | MP0001697_abnormal_embryo_size | 1.94445750 |
| 24 | MP0005380_embryogenesis_phenotype | 1.91899263 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.91899263 |
| 26 | MP0002085_abnormal_embryonic_tissue | 1.90850747 |
| 27 | MP0003941_abnormal_skin_development | 1.87874781 |
| 28 | MP0001293_anophthalmia | 1.82525564 |
| 29 | MP0003984_embryonic_growth_retardation | 1.76222264 |
| 30 | MP0002088_abnormal_embryonic_growth/wei | 1.74755776 |
| 31 | MP0008932_abnormal_embryonic_tissue | 1.73426550 |
| 32 | MP0010234_abnormal_vibrissa_follicle | 1.68635851 |
| 33 | MP0004233_abnormal_muscle_weight | 1.67304397 |
| 34 | MP0004272_abnormal_basement_membrane | 1.63679024 |
| 35 | MP0003119_abnormal_digestive_system | 1.62098220 |
| 36 | MP0000569_abnormal_digit_pigmentation | 1.61594895 |
| 37 | MP0003121_genomic_imprinting | 1.61377402 |
| 38 | MP0008007_abnormal_cellular_replicative | 1.59966907 |
| 39 | MP0002080_prenatal_lethality | 1.55740632 |
| 40 | MP0008058_abnormal_DNA_repair | 1.49719922 |
| 41 | MP0003283_abnormal_digestive_organ | 1.39768399 |
| 42 | MP0003221_abnormal_cardiomyocyte_apopto | 1.38749243 |
| 43 | MP0009697_abnormal_copulation | 1.37629393 |
| 44 | MP0002396_abnormal_hematopoietic_system | 1.32076590 |
| 45 | MP0003566_abnormal_cell_adhesion | 1.31788166 |
| 46 | MP0008877_abnormal_DNA_methylation | 1.31166543 |
| 47 | MP0000733_abnormal_muscle_development | 1.30455576 |
| 48 | MP0002282_abnormal_trachea_morphology | 1.30233202 |
| 49 | MP0001299_abnormal_eye_distance/ | 1.27257523 |
| 50 | MP0003935_abnormal_craniofacial_develop | 1.27156440 |
| 51 | MP0002009_preneoplasia | 1.25551670 |
| 52 | MP0005257_abnormal_intraocular_pressure | 1.22725149 |
| 53 | MP0009703_decreased_birth_body | 1.22656148 |
| 54 | MP0001849_ear_inflammation | 1.21200325 |
| 55 | MP0000490_abnormal_crypts_of | 1.20897196 |
| 56 | MP0000428_abnormal_craniofacial_morphol | 1.20795050 |
| 57 | MP0004808_abnormal_hematopoietic_stem | 1.20176948 |
| 58 | MP0002092_abnormal_eye_morphology | 1.19219398 |
| 59 | MP0002877_abnormal_melanocyte_morpholog | 1.18842491 |
| 60 | MP0003937_abnormal_limbs/digits/tail_de | 1.18419286 |
| 61 | MP0005397_hematopoietic_system_phenotyp | 1.17589122 |
| 62 | MP0001545_abnormal_hematopoietic_system | 1.17589122 |
| 63 | MP0005409_darkened_coat_color | 1.17243106 |
| 64 | MP0002111_abnormal_tail_morphology | 1.17110232 |
| 65 | MP0003115_abnormal_respiratory_system | 1.16534363 |
| 66 | MP0002697_abnormal_eye_size | 1.15462407 |
| 67 | MP0006054_spinal_hemorrhage | 1.14118140 |
| 68 | MP0003385_abnormal_body_wall | 1.13306708 |
| 69 | MP0003315_abnormal_perineum_morphology | 1.11677843 |
| 70 | MP0001915_intracranial_hemorrhage | 1.10319463 |
| 71 | MP0000371_diluted_coat_color | 1.09572219 |
| 72 | MP0005623_abnormal_meninges_morphology | 1.08195473 |
| 73 | MP0005187_abnormal_penis_morphology | 1.07161027 |
| 74 | MP0000432_abnormal_head_morphology | 1.06994071 |
| 75 | MP0005501_abnormal_skin_physiology | 1.06835744 |
| 76 | MP0002796_impaired_skin_barrier | 1.04910816 |
| 77 | MP0002932_abnormal_joint_morphology | 1.04795021 |
| 78 | MP0005023_abnormal_wound_healing | 1.03983728 |
| 79 | MP0000762_abnormal_tongue_morphology | 1.03742806 |
| 80 | MP0005171_absent_coat_pigmentation | 1.03737549 |
| 81 | MP0002653_abnormal_ependyma_morphology | 1.01752861 |
| 82 | MP0003755_abnormal_palate_morphology | 1.01730008 |
| 83 | MP0002925_abnormal_cardiovascular_devel | 1.01639021 |
| 84 | MP0008438_abnormal_cutaneous_collagen | 1.01049997 |
| 85 | MP0009672_abnormal_birth_weight | 1.00393068 |
| 86 | MP0002233_abnormal_nose_morphology | 1.00378485 |
| 87 | MP0005621_abnormal_cell_physiology | 0.99476538 |
| 88 | MP0004264_abnormal_extraembryonic_tissu | 0.98569081 |
| 89 | MP0002060_abnormal_skin_morphology | 0.96915330 |
| 90 | MP0003942_abnormal_urinary_system | 0.95918266 |
| 91 | MP0010678_abnormal_skin_adnexa | 0.94998391 |
| 92 | MP0000462_abnormal_digestive_system | 0.94864237 |
| 93 | MP0000579_abnormal_nail_morphology | 0.92655636 |
| 94 | MP0003861_abnormal_nervous_system | 0.92504038 |
| 95 | MP0002019_abnormal_tumor_incidence | 0.92272028 |
| 96 | MP0004133_heterotaxia | 0.92145764 |
| 97 | MP0002249_abnormal_larynx_morphology | 0.91806713 |
| 98 | MP0000313_abnormal_cell_death | 0.91651293 |
| 99 | MP0000778_abnormal_nervous_system | 0.89632474 |
| 100 | MP0000516_abnormal_urinary_system | 0.87080082 |
| 101 | MP0005367_renal/urinary_system_phenotyp | 0.87080082 |
| 102 | * MP0002081_perinatal_lethality | 0.86785991 |
| 103 | MP0005384_cellular_phenotype | 0.86522757 |
| 104 | MP0001346_abnormal_lacrimal_gland | 0.86407032 |
| 105 | MP0005248_abnormal_Harderian_gland | 0.86157320 |
| 106 | MP0004858_abnormal_nervous_system | 0.83915323 |
| 107 | MP0003786_premature_aging | 0.83737096 |
| 108 | MP0002938_white_spotting | 0.82937083 |
| 109 | MP0002114_abnormal_axial_skeleton | 0.82815767 |
| 110 | MP0001661_extended_life_span | 0.82539342 |
| 111 | MP0001177_atelectasis | 0.82218430 |
| 112 | MP0002116_abnormal_craniofacial_bone | 0.81933964 |
| 113 | MP0000566_synostosis | 0.80928455 |
| 114 | MP0001286_abnormal_eye_development | 0.80358163 |
| 115 | MP0000377_abnormal_hair_follicle | 0.79306707 |
| 116 | MP0008770_decreased_survivor_rate | 0.79104975 |
| 117 | MP0001340_abnormal_eyelid_morphology | 0.77697456 |
| 118 | MP0004782_abnormal_surfactant_physiolog | 0.77237564 |
| 119 | MP0010368_abnormal_lymphatic_system | 0.77094298 |
| 120 | MP0002075_abnormal_coat/hair_pigmentati | 0.77059419 |
| 121 | MP0000534_abnormal_ureter_morphology | 0.76555948 |
| 122 | MP0004185_abnormal_adipocyte_glucose | 0.74744179 |
| 123 | MP0000266_abnormal_heart_morphology | 0.74519940 |
| 124 | MP0010630_abnormal_cardiac_muscle | 0.74428749 |
| 125 | MP0003300_gastrointestinal_ulcer | 0.73189561 |
| 126 | MP0002896_abnormal_bone_mineralization | 0.72958040 |
| 127 | MP0003091_abnormal_cell_migration | 0.72451236 |
| 128 | MP0000477_abnormal_intestine_morphology | 0.71884189 |
| 129 | MP0003453_abnormal_keratinocyte_physiol | 0.71576794 |
| 130 | MP0001784_abnormal_fluid_regulation | 0.69425880 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 3.73532181 |
| 2 | Short 4th metacarpal (HP:0010044) | 3.68665070 |
| 3 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.68665070 |
| 4 | Ependymoma (HP:0002888) | 3.28360281 |
| 5 | Facial hemangioma (HP:0000329) | 3.25356223 |
| 6 | Abnormality of the astrocytes (HP:0100707) | 3.22254767 |
| 7 | Astrocytoma (HP:0009592) | 3.22254767 |
| 8 | Selective tooth agenesis (HP:0001592) | 3.12360881 |
| 9 | Abnormality of the 4th metacarpal (HP:0010012) | 2.91150772 |
| 10 | Insidious onset (HP:0003587) | 2.87908985 |
| 11 | Termporal pattern (HP:0011008) | 2.87908985 |
| 12 | Colon cancer (HP:0003003) | 2.74619719 |
| 13 | Increased nuchal translucency (HP:0010880) | 2.70099333 |
| 14 | Medulloblastoma (HP:0002885) | 2.69979903 |
| 15 | Asymmetry of the thorax (HP:0001555) | 2.63117579 |
| 16 | Deviation of the thumb (HP:0009603) | 2.62899379 |
| 17 | Neoplasm of the oral cavity (HP:0100649) | 2.62392108 |
| 18 | Short humerus (HP:0005792) | 2.60873526 |
| 19 | Proximal placement of thumb (HP:0009623) | 2.60634684 |
| 20 | Cerebral aneurysm (HP:0004944) | 2.59096210 |
| 21 | Premature rupture of membranes (HP:0001788) | 2.57155665 |
| 22 | Ulnar bowing (HP:0003031) | 2.56652030 |
| 23 | Deep philtrum (HP:0002002) | 2.56020125 |
| 24 | Basal cell carcinoma (HP:0002671) | 2.55641280 |
| 25 | Rib fusion (HP:0000902) | 2.55003691 |
| 26 | Insomnia (HP:0100785) | 2.53772035 |
| 27 | Glioma (HP:0009733) | 2.53009784 |
| 28 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.45805705 |
| 29 | Renal duplication (HP:0000075) | 2.44468402 |
| 30 | High anterior hairline (HP:0009890) | 2.40870452 |
| 31 | Abnormality of the labia minora (HP:0012880) | 2.40255899 |
| 32 | Hyperacusis (HP:0010780) | 2.39239574 |
| 33 | Heterotopia (HP:0002282) | 2.36830382 |
| 34 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.34600748 |
| 35 | Chromsome breakage (HP:0040012) | 2.32393260 |
| 36 | Shallow orbits (HP:0000586) | 2.31189432 |
| 37 | Papillary thyroid carcinoma (HP:0002895) | 2.30995408 |
| 38 | Rhabdomyosarcoma (HP:0002859) | 2.27842767 |
| 39 | Broad thumb (HP:0011304) | 2.26807580 |
| 40 | Subacute progressive viral hepatitis (HP:0006572) | 2.22624476 |
| 41 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.21031791 |
| 42 | Gastrointestinal carcinoma (HP:0002672) | 2.21031791 |
| 43 | Vertebral arch anomaly (HP:0008438) | 2.20796660 |
| 44 | Annular pancreas (HP:0001734) | 2.13960241 |
| 45 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.13555971 |
| 46 | Missing ribs (HP:0000921) | 2.12083179 |
| 47 | Abnormal number of incisors (HP:0011064) | 2.10755403 |
| 48 | Shoulder girdle muscle weakness (HP:0003547) | 2.09481098 |
| 49 | Macroorchidism (HP:0000053) | 2.09475544 |
| 50 | Protrusio acetabuli (HP:0003179) | 2.08887229 |
| 51 | Overlapping toe (HP:0001845) | 2.08261657 |
| 52 | Neoplasm of striated muscle (HP:0009728) | 2.07610664 |
| 53 | Ankle contracture (HP:0006466) | 2.05066159 |
| 54 | Coronal craniosynostosis (HP:0004440) | 2.04777188 |
| 55 | Relative macrocephaly (HP:0004482) | 2.03575860 |
| 56 | Turricephaly (HP:0000262) | 2.03084183 |
| 57 | Embryonal renal neoplasm (HP:0011794) | 2.02945199 |
| 58 | Flat acetabular roof (HP:0003180) | 2.01581409 |
| 59 | Biliary tract neoplasm (HP:0100574) | 2.00645202 |
| 60 | Abnormality of oral frenula (HP:0000190) | 2.00185222 |
| 61 | Bowel diverticulosis (HP:0005222) | 1.99931292 |
| 62 | Renovascular hypertension (HP:0100817) | 1.99300094 |
| 63 | Leiomyosarcoma (HP:0100243) | 1.99097619 |
| 64 | Uterine leiomyosarcoma (HP:0002891) | 1.99097619 |
| 65 | Pseudobulbar signs (HP:0002200) | 1.98495508 |
| 66 | Patellar aplasia (HP:0006443) | 1.98490614 |
| 67 | Abnormality of the lower motor neuron (HP:0002366) | 1.95106424 |
| 68 | Hypochromic microcytic anemia (HP:0004840) | 1.94590274 |
| 69 | Broad alveolar ridges (HP:0000187) | 1.93741701 |
| 70 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.92029008 |
| 71 | Obsessive-compulsive behavior (HP:0000722) | 1.91962052 |
| 72 | Orthostatic hypotension (HP:0001278) | 1.91005669 |
| 73 | Absent radius (HP:0003974) | 1.90757909 |
| 74 | Cutaneous melanoma (HP:0012056) | 1.87293368 |
| 75 | Broad phalanges of the hand (HP:0009768) | 1.87129820 |
| 76 | Broad palm (HP:0001169) | 1.85416726 |
| 77 | Back pain (HP:0003418) | 1.85403347 |
| 78 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.85357563 |
| 79 | Pelvic girdle muscle weakness (HP:0003749) | 1.84973156 |
| 80 | Short 5th finger (HP:0009237) | 1.84698554 |
| 81 | Arnold-Chiari malformation (HP:0002308) | 1.84530331 |
| 82 | Vertebral hypoplasia (HP:0008417) | 1.83982231 |
| 83 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.83982231 |
| 84 | Fibrous tissue neoplasm (HP:0012316) | 1.82426173 |
| 85 | Squamous cell carcinoma (HP:0002860) | 1.80209670 |
| 86 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.80100753 |
| 87 | Poikiloderma (HP:0001029) | 1.79917341 |
| 88 | Trigonocephaly (HP:0000243) | 1.79739956 |
| 89 | Abnormality of the calcaneus (HP:0008364) | 1.79551505 |
| 90 | Atresia of the external auditory canal (HP:0000413) | 1.79103265 |
| 91 | Long eyelashes (HP:0000527) | 1.79062234 |
| 92 | Hammertoe (HP:0001765) | 1.79004072 |
| 93 | Fibroma (HP:0010614) | 1.78867696 |
| 94 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.78429620 |
| 95 | Large earlobe (HP:0009748) | 1.77686488 |
| 96 | Absent forearm bone (HP:0003953) | 1.77005243 |
| 97 | Aplasia involving forearm bones (HP:0009822) | 1.77005243 |
| 98 | Skull defect (HP:0001362) | 1.76683865 |
| 99 | Spinal cord lesions (HP:0100561) | 1.76460485 |
| 100 | Syringomyelia (HP:0003396) | 1.76460485 |
| 101 | Rectal fistula (HP:0100590) | 1.76292617 |
| 102 | Rectovaginal fistula (HP:0000143) | 1.76292617 |
| 103 | Elfin facies (HP:0004428) | 1.76118419 |
| 104 | Spastic diplegia (HP:0001264) | 1.75806885 |
| 105 | Prominent nose (HP:0000448) | 1.75581309 |
| 106 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.74210183 |
| 107 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.74210183 |
| 108 | Ankyloglossia (HP:0010296) | 1.74107277 |
| 109 | Rectal prolapse (HP:0002035) | 1.73878590 |
| 110 | Abnormality of the anterior horn cell (HP:0006802) | 1.73678356 |
| 111 | Degeneration of anterior horn cells (HP:0002398) | 1.73678356 |
| 112 | Cutis marmorata (HP:0000965) | 1.73091489 |
| 113 | Long palpebral fissure (HP:0000637) | 1.72782934 |
| 114 | Cortical dysplasia (HP:0002539) | 1.72094585 |
| 115 | Pointed chin (HP:0000307) | 1.72042261 |
| 116 | Increased number of teeth (HP:0011069) | 1.72019626 |
| 117 | Increased density of long bones (HP:0006392) | 1.71116512 |
| 118 | Intestinal fistula (HP:0100819) | 1.70885999 |
| 119 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.69654707 |
| 120 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.69557454 |
| 121 | Uterine neoplasm (HP:0010784) | 1.69359134 |
| 122 | Supernumerary ribs (HP:0005815) | 1.69342343 |
| 123 | Bladder diverticulum (HP:0000015) | 1.68726992 |
| 124 | Broad finger (HP:0001500) | 1.68459028 |
| 125 | Disproportionate tall stature (HP:0001519) | 1.67840084 |
| 126 | Bladder carcinoma (HP:0002862) | 1.67745804 |
| 127 | Bladder neoplasm (HP:0009725) | 1.67745804 |
| 128 | Genu recurvatum (HP:0002816) | 1.67637984 |
| 129 | Abnormality of abdominal situs (HP:0011620) | 1.67179672 |
| 130 | Abdominal situs inversus (HP:0003363) | 1.67179672 |
| 131 | Sandal gap (HP:0001852) | 1.66982446 |
| 132 | Abnormality of the diencephalon (HP:0010662) | 1.66621479 |
| 133 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.66094785 |
| 134 | Breech presentation (HP:0001623) | 1.66084265 |
| 135 | Microglossia (HP:0000171) | 1.65804537 |
| 136 | Skin tags (HP:0010609) | 1.65735878 |
| 137 | Intestinal polyp (HP:0005266) | 1.65259013 |
| 138 | Spinal muscular atrophy (HP:0007269) | 1.65204699 |
| 139 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.64931934 |
| 140 | Overriding aorta (HP:0002623) | 1.64840870 |
| 141 | Cafe-au-lait spot (HP:0000957) | 1.63829796 |
| 142 | Advanced eruption of teeth (HP:0006288) | 1.61641249 |
| 143 | Thyroid carcinoma (HP:0002890) | 1.58552414 |
| 144 | Curly hair (HP:0002212) | 1.57704605 |
| 145 | Spina bifida occulta (HP:0003298) | 1.56423250 |
| 146 | Glossoptosis (HP:0000162) | 1.56281129 |
| 147 | Patellar dislocation (HP:0002999) | 1.56259109 |
| 148 | Abnormality of chromosome segregation (HP:0002916) | 1.54479922 |
| 149 | Rhizomelia (HP:0008905) | 1.53211882 |
| 150 | Midface retrusion (HP:0011800) | 1.49689502 |
| 151 | Flat cornea (HP:0007720) | 1.49629022 |
| 152 | Short nail (HP:0001799) | 1.49299999 |
| 153 | Acute myeloid leukemia (HP:0004808) | 1.48773910 |
| 154 | Lower limb amyotrophy (HP:0007210) | 1.47784860 |
| 155 | Dysmetric saccades (HP:0000641) | 1.47618938 |
| 156 | Hypopigmentation of the fundus (HP:0007894) | 1.47358770 |
| 157 | Capillary hemangiomas (HP:0005306) | 1.46509085 |
| 158 | Wormian bones (HP:0002645) | 1.46001490 |
| 159 | Distal lower limb amyotrophy (HP:0008944) | 1.44660166 |
| 160 | Multiple enchondromatosis (HP:0005701) | 1.44200779 |
| 161 | Natal tooth (HP:0000695) | 1.43973477 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 3.58959688 |
| 2 | ICK | 3.11322709 |
| 3 | CDK12 | 3.10714412 |
| 4 | DDR2 | 2.62525146 |
| 5 | PKN2 | 2.52356682 |
| 6 | EEF2K | 2.46799278 |
| 7 | MAP3K10 | 2.38000602 |
| 8 | NEK2 | 2.37736546 |
| 9 | TRIB3 | 2.24695260 |
| 10 | PDGFRA | 2.20626290 |
| 11 | WEE1 | 2.06993165 |
| 12 | CDK6 | 2.06700626 |
| 13 | NEK1 | 2.03520816 |
| 14 | SMG1 | 1.98978781 |
| 15 | SCYL2 | 1.94767237 |
| 16 | BCR | 1.94727680 |
| 17 | LATS1 | 1.89892446 |
| 18 | PBK | 1.76301699 |
| 19 | RPS6KB2 | 1.64013393 |
| 20 | TYRO3 | 1.63175315 |
| 21 | EIF2AK1 | 1.62446576 |
| 22 | CDK7 | 1.58324374 |
| 23 | BMX | 1.46292631 |
| 24 | TTK | 1.46109967 |
| 25 | ATR | 1.45959158 |
| 26 | LATS2 | 1.43973955 |
| 27 | MTOR | 1.41834510 |
| 28 | MAP3K6 | 1.41019844 |
| 29 | PASK | 1.39450468 |
| 30 | MST1R | 1.35093535 |
| 31 | MKNK1 | 1.31920560 |
| 32 | ALK | 1.31242589 |
| 33 | CDK4 | 1.29846996 |
| 34 | PLK1 | 1.29153617 |
| 35 | CHEK2 | 1.27481005 |
| 36 | BRD4 | 1.25122536 |
| 37 | DYRK3 | 1.22648103 |
| 38 | DYRK1B | 1.20855329 |
| 39 | ERBB3 | 1.19362942 |
| 40 | STK3 | 1.19169222 |
| 41 | NEK9 | 1.16082289 |
| 42 | TAF1 | 1.15669550 |
| 43 | CHEK1 | 1.15615489 |
| 44 | MAP3K8 | 1.15539426 |
| 45 | FGFR1 | 1.15071406 |
| 46 | STK10 | 1.14174141 |
| 47 | PAK4 | 1.12157528 |
| 48 | RIPK1 | 1.11302943 |
| 49 | AURKB | 1.10578681 |
| 50 | PTK6 | 1.07858418 |
| 51 | PLK4 | 1.06916746 |
| 52 | SRPK1 | 1.06838547 |
| 53 | NTRK1 | 1.06644087 |
| 54 | EIF2AK3 | 1.03947811 |
| 55 | TGFBR1 | 1.02541247 |
| 56 | TTN | 1.01703253 |
| 57 | CAMK1D | 1.00068097 |
| 58 | PAK2 | 0.96936318 |
| 59 | CDK2 | 0.95919274 |
| 60 | FLT3 | 0.95281084 |
| 61 | ATM | 0.95252488 |
| 62 | TSSK6 | 0.94887015 |
| 63 | FGR | 0.93312818 |
| 64 | BUB1 | 0.93263533 |
| 65 | MAP3K11 | 0.92313395 |
| 66 | PLK3 | 0.92225588 |
| 67 | EPHA2 | 0.90486360 |
| 68 | PIM1 | 0.89907154 |
| 69 | ERBB4 | 0.89690566 |
| 70 | MATK | 0.87720104 |
| 71 | KSR2 | 0.86443096 |
| 72 | RPS6KA4 | 0.85947433 |
| 73 | BRSK2 | 0.85861002 |
| 74 | ACVR1B | 0.84267209 |
| 75 | UHMK1 | 0.80981966 |
| 76 | TRIM28 | 0.80041670 |
| 77 | LRRK2 | 0.78568658 |
| 78 | TESK2 | 0.78205429 |
| 79 | FGFR4 | 0.77682133 |
| 80 | CDK18 | 0.74687741 |
| 81 | PDGFRB | 0.74129688 |
| 82 | CDK9 | 0.73305641 |
| 83 | CDK1 | 0.71988779 |
| 84 | MAP3K4 | 0.71807957 |
| 85 | CAMK1G | 0.71538733 |
| 86 | CDK15 | 0.71135777 |
| 87 | CSK | 0.70035328 |
| 88 | BRAF | 0.69027923 |
| 89 | CDK11A | 0.68585232 |
| 90 | CDK14 | 0.68453254 |
| 91 | SIK1 | 0.67007835 |
| 92 | YES1 | 0.66993150 |
| 93 | CLK1 | 0.66908997 |
| 94 | PRPF4B | 0.66780676 |
| 95 | AKT3 | 0.64102772 |
| 96 | STK38L | 0.64079575 |
| 97 | KSR1 | 0.63864384 |
| 98 | MKNK2 | 0.63819085 |
| 99 | TRPM7 | 0.62874913 |
| 100 | MELK | 0.62577318 |
| 101 | PNCK | 0.62015572 |
| 102 | PRKD3 | 0.59548132 |
| 103 | GSK3A | 0.58721565 |
| 104 | DAPK1 | 0.58077281 |
| 105 | RET | 0.56307125 |
| 106 | STK4 | 0.55151477 |
| 107 | PTK2 | 0.54412880 |
| 108 | MAP2K7 | 0.53319454 |
| 109 | AKT2 | 0.53215349 |
| 110 | EIF2AK2 | 0.52124545 |
| 111 | PRKDC | 0.51722097 |
| 112 | MAPK14 | 0.51196599 |
| 113 | CSNK1E | 0.50850950 |
| 114 | RAF1 | 0.50195520 |
| 115 | RPS6KL1 | 0.50051643 |
| 116 | RPS6KC1 | 0.50051643 |
| 117 | TESK1 | 0.49534195 |
| 118 | CDK8 | 0.48702078 |
| 119 | AURKA | 0.48654420 |
| 120 | MET | 0.48313129 |
| 121 | MAPK10 | 0.48059562 |
| 122 | FGFR2 | 0.47819596 |
| 123 | RPS6KA1 | 0.47482118 |
| 124 | CSNK1D | 0.45731372 |
| 125 | CSNK1G1 | 0.45269733 |
| 126 | NEK6 | 0.44891514 |
| 127 | MAPK11 | 0.43168451 |
| 128 | EGFR | 0.43134292 |
| 129 | CDC42BPA | 0.42662224 |
| 130 | CSNK2A2 | 0.42277787 |
| 131 | MAPK1 | 0.42139088 |
| 132 | EPHB2 | 0.41661117 |
| 133 | RPS6KB1 | 0.40175284 |
| 134 | CSNK1A1L | 0.39593599 |
| 135 | BRSK1 | 0.39164640 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 3.56777346 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.51685363 |
| 3 | RNA transport_Homo sapiens_hsa03013 | 2.87324496 |
| 4 | Cell cycle_Homo sapiens_hsa04110 | 2.72497815 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 2.63648033 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 2.62534862 |
| 7 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.40775480 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.33573002 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.17005426 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.92554068 |
| 11 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.80947829 |
| 12 | Adherens junction_Homo sapiens_hsa04520 | 1.80941156 |
| 13 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.79538549 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.77079387 |
| 15 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.74692200 |
| 16 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.73545722 |
| 17 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.70560011 |
| 18 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.60594886 |
| 19 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.59468881 |
| 20 | Colorectal cancer_Homo sapiens_hsa05210 | 1.59108542 |
| 21 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.51917067 |
| 22 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.51495769 |
| 23 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.51442230 |
| 24 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.48126708 |
| 25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.42033452 |
| 26 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.41702026 |
| 27 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.40752990 |
| 28 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.39301397 |
| 29 | Lysine degradation_Homo sapiens_hsa00310 | 1.39255989 |
| 30 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.38514062 |
| 31 | Homologous recombination_Homo sapiens_hsa03440 | 1.37566190 |
| 32 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.36374250 |
| 33 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.35215279 |
| 34 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.34539373 |
| 35 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.31912898 |
| 36 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.31357292 |
| 37 | Thyroid cancer_Homo sapiens_hsa05216 | 1.27740567 |
| 38 | Bladder cancer_Homo sapiens_hsa05219 | 1.22401945 |
| 39 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.20501368 |
| 40 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.20488111 |
| 41 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.20309957 |
| 42 | Endometrial cancer_Homo sapiens_hsa05213 | 1.18647177 |
| 43 | Viral myocarditis_Homo sapiens_hsa05416 | 1.16563783 |
| 44 | Carbon metabolism_Homo sapiens_hsa01200 | 1.13869505 |
| 45 | HTLV-I infection_Homo sapiens_hsa05166 | 1.12769415 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.08091553 |
| 47 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.05721304 |
| 48 | RNA degradation_Homo sapiens_hsa03018 | 1.05304309 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.04975907 |
| 50 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.04691434 |
| 51 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.00603268 |
| 52 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.97767847 |
| 53 | Prostate cancer_Homo sapiens_hsa05215 | 0.93047734 |
| 54 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.91632517 |
| 55 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.91607836 |
| 56 | Focal adhesion_Homo sapiens_hsa04510 | 0.91162688 |
| 57 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.91119111 |
| 58 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.90050382 |
| 59 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.86756636 |
| 60 | Tight junction_Homo sapiens_hsa04530 | 0.86267794 |
| 61 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.84516684 |
| 62 | Shigellosis_Homo sapiens_hsa05131 | 0.83826069 |
| 63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.82011828 |
| 64 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.81772846 |
| 65 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.81232938 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.80144395 |
| 67 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.79922808 |
| 68 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.79625535 |
| 69 | Axon guidance_Homo sapiens_hsa04360 | 0.78574522 |
| 70 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.78202287 |
| 71 | Pathways in cancer_Homo sapiens_hsa05200 | 0.77603758 |
| 72 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.76856184 |
| 73 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.76498126 |
| 74 | Glioma_Homo sapiens_hsa05214 | 0.75981917 |
| 75 | Hepatitis B_Homo sapiens_hsa05161 | 0.75640791 |
| 76 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.75292885 |
| 77 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.74371135 |
| 78 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.74238892 |
| 79 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.72967213 |
| 80 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.72375379 |
| 81 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.71232662 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.69473186 |
| 83 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.68212551 |
| 84 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.66313939 |
| 85 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.65776688 |
| 86 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.65317472 |
| 87 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.65101216 |
| 88 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.63477303 |
| 89 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.61909397 |
| 90 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.61417120 |
| 91 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.61061039 |
| 92 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.60402599 |
| 93 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.59583002 |
| 94 | Melanoma_Homo sapiens_hsa05218 | 0.58806749 |
| 95 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.58705366 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.58585574 |
| 97 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.57043908 |
| 98 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.56329650 |
| 99 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.55660449 |
| 100 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.55633661 |
| 101 | Legionellosis_Homo sapiens_hsa05134 | 0.54650430 |
| 102 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.53387725 |
| 103 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.50479207 |
| 104 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.50084549 |
| 105 | Apoptosis_Homo sapiens_hsa04210 | 0.45475726 |
| 106 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.44404261 |
| 107 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.44308554 |
| 108 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.41317757 |
| 109 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.41260354 |
| 110 | Basal transcription factors_Homo sapiens_hsa03022 | 0.40944986 |
| 111 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40334785 |
| 112 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.39852876 |
| 113 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.37062479 |
| 114 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.36874144 |
| 115 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.35926649 |
| 116 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.35307341 |
| 117 | Insulin resistance_Homo sapiens_hsa04931 | 0.34005882 |
| 118 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.33005539 |
| 119 | Melanogenesis_Homo sapiens_hsa04916 | 0.31997970 |
| 120 | Gap junction_Homo sapiens_hsa04540 | 0.31569944 |
| 121 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.31085196 |

