CAPRIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.43461950
2vitamin transmembrane transport (GO:0035461)6.94255415
3lens development in camera-type eye (GO:0002088)6.29421067
4nuclear pore complex assembly (GO:0051292)6.26123470
5definitive hemopoiesis (GO:0060216)6.19724609
6N-terminal protein amino acid acetylation (GO:0006474)5.90273887
7regulation of centriole replication (GO:0046599)5.75716027
8nuclear pore organization (GO:0006999)5.68254587
9monoubiquitinated protein deubiquitination (GO:0035520)5.63869226
10response to UV-C (GO:0010225)5.60911943
11piRNA metabolic process (GO:0034587)5.43616830
12resolution of meiotic recombination intermediates (GO:0000712)5.22973402
13sprouting angiogenesis (GO:0002040)5.18032380
14DNA methylation involved in gamete generation (GO:0043046)5.06229798
15positive regulation of cellular amide metabolic process (GO:0034250)5.04261357
16pore complex assembly (GO:0046931)5.00560166
17positive regulation of actin cytoskeleton reorganization (GO:2000251)4.82827761
18meiotic chromosome segregation (GO:0045132)4.73867278
19regulation of establishment or maintenance of cell polarity (GO:0032878)4.72136052
20heart trabecula formation (GO:0060347)4.58384891
21regulation of meiosis I (GO:0060631)4.30248826
22positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)4.29800818
23vitamin biosynthetic process (GO:0009110)4.06896099
24positive regulation of lipid kinase activity (GO:0090218)4.06756791
25vascular endothelial growth factor signaling pathway (GO:0038084)4.06400426
26positive regulation of cell junction assembly (GO:1901890)3.97439202
27positive regulation of focal adhesion assembly (GO:0051894)3.97439202
28head development (GO:0060322)3.95071553
29synaptonemal complex assembly (GO:0007130)3.88657607
30positive regulation of protein homodimerization activity (GO:0090073)3.82639289
31protein targeting to Golgi (GO:0000042)3.79530265
32regulation of vascular permeability (GO:0043114)3.73951174
33negative regulation of endothelial cell apoptotic process (GO:2000352)3.73583340
34diaphragm development (GO:0060539)3.71322841
35blood vessel maturation (GO:0001955)3.65128138
36muscle atrophy (GO:0014889)3.64962240
37positive regulation of adherens junction organization (GO:1903393)3.64335563
38lens fiber cell differentiation (GO:0070306)3.62420325
39positive regulation of vascular permeability (GO:0043117)3.61951176
40positive regulation of translational initiation (GO:0045948)3.52957295
41ear development (GO:0043583)3.52029866
42auditory behavior (GO:0031223)3.49730536
43endothelial cell proliferation (GO:0001935)3.48183899
44trabecula formation (GO:0060343)3.47623982
45male meiosis (GO:0007140)3.45576320
46iron ion import (GO:0097286)3.44645440
47kinetochore organization (GO:0051383)3.40560086
48synaptonemal complex organization (GO:0070193)3.36454009
49retrograde transport, vesicle recycling within Golgi (GO:0000301)3.35995760
50kinetochore assembly (GO:0051382)3.35328002
51DNA synthesis involved in DNA repair (GO:0000731)3.34091866
52chromosome organization involved in meiosis (GO:0070192)3.33986836
53replicative senescence (GO:0090399)3.32788982
54synapsis (GO:0007129)3.27707634
55import into cell (GO:0098657)3.24490382
56male sex determination (GO:0030238)3.24222278
57paraxial mesoderm development (GO:0048339)3.23429859
58protein K6-linked ubiquitination (GO:0085020)3.21688784
59DNA alkylation (GO:0006305)3.19088310
60DNA methylation (GO:0006306)3.19088310
61skeletal muscle organ development (GO:0060538)3.16059292
62protein localization to synapse (GO:0035418)3.11999914
63N-terminal protein amino acid modification (GO:0031365)3.10904678
64monocyte chemotaxis (GO:0002548)3.07380543
65lens fiber cell development (GO:0070307)3.04575665
66regulation of phosphatidylinositol 3-kinase activity (GO:0043551)3.03653587
67regulation of centrosome cycle (GO:0046605)3.03529136
68S-adenosylmethionine metabolic process (GO:0046500)3.03197782
69establishment of protein localization to Golgi (GO:0072600)3.01979950
70synaptic vesicle docking involved in exocytosis (GO:0016081)3.01506797
71smooth muscle tissue development (GO:0048745)3.00892521
72male meiosis I (GO:0007141)3.00267772
73negative regulation of vascular permeability (GO:0043116)2.99332136
74presynaptic membrane organization (GO:0097090)2.97707597
75interkinetic nuclear migration (GO:0022027)2.95168715
76intra-S DNA damage checkpoint (GO:0031573)2.94804775
77mitotic sister chromatid cohesion (GO:0007064)2.94438727
78female genitalia development (GO:0030540)2.94259032
79regulation of protein sumoylation (GO:0033233)2.94153264
80regulation of centrosome duplication (GO:0010824)2.92941210
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.92858058
82regulation of translation, ncRNA-mediated (GO:0045974)2.92858058
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92858058
84reciprocal meiotic recombination (GO:0007131)2.92293734
85reciprocal DNA recombination (GO:0035825)2.92293734
86presynaptic membrane assembly (GO:0097105)2.91521836
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90614183
88mitotic metaphase plate congression (GO:0007080)2.89975791
89positive regulation of meiosis (GO:0045836)2.88694964
90regulation of histone H3-K9 methylation (GO:0051570)2.88425601
91eyelid development in camera-type eye (GO:0061029)2.86750703
92viral protein processing (GO:0019082)2.86411136
93lung vasculature development (GO:0060426)2.85956823
94maturation of 5.8S rRNA (GO:0000460)2.84590226
95regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.83022193
96metaphase plate congression (GO:0051310)2.79101531
97embryonic digestive tract development (GO:0048566)2.78061221
98histone deubiquitination (GO:0016578)2.74095529
99establishment of nucleus localization (GO:0040023)2.73961255
100cerebellar Purkinje cell differentiation (GO:0021702)2.73614469
101positive regulation by host of viral transcription (GO:0043923)2.72545888
102chromatin remodeling at centromere (GO:0031055)2.71978892
103sister chromatid cohesion (GO:0007062)2.70265970
104histone H3-K9 demethylation (GO:0033169)2.69749730
105vocalization behavior (GO:0071625)2.69501539
106negative regulation of protein localization to cell surface (GO:2000009)2.69387424
107centriole assembly (GO:0098534)2.66180915
108GDP-mannose metabolic process (GO:0019673)2.65309898
109nucleus localization (GO:0051647)2.64200122
110pyrimidine dimer repair (GO:0006290)2.63605010
111neurotransmitter-gated ion channel clustering (GO:0072578)2.62604088
112cAMP catabolic process (GO:0006198)2.61464127
113apical protein localization (GO:0045176)2.60841182
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60602831
115regulation of mitotic spindle checkpoint (GO:1903504)2.60602831
116DNA replication checkpoint (GO:0000076)2.59350439
117embryonic foregut morphogenesis (GO:0048617)2.59133225
118regulation of endothelial cell apoptotic process (GO:2000351)2.59108004
119mechanosensory behavior (GO:0007638)2.58963856
120DNA methylation or demethylation (GO:0044728)2.58900156
121gene silencing by RNA (GO:0031047)2.58545751
122positive regulation of meiotic cell cycle (GO:0051446)2.58200215
123glutamate secretion (GO:0014047)2.57696190
124regulation of posttranscriptional gene silencing (GO:0060147)2.56683680
125regulation of gene silencing by miRNA (GO:0060964)2.56683680
126regulation of gene silencing by RNA (GO:0060966)2.56683680
127postsynaptic membrane organization (GO:0001941)2.54648232
128regulation of protein polyubiquitination (GO:1902914)2.54282187
129neuronal action potential propagation (GO:0019227)2.51783774
130embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51513978
131* positive regulation of dendritic spine morphogenesis (GO:0061003)2.51339884
132regulation of non-canonical Wnt signaling pathway (GO:2000050)2.50885693
133protein K11-linked deubiquitination (GO:0035871)2.50238200
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47681631
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47641512
136cerebral cortex radially oriented cell migration (GO:0021799)2.47488953
137axonal fasciculation (GO:0007413)2.45929073
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45845296
139regulation of DNA endoreduplication (GO:0032875)2.43758435
140neuron recognition (GO:0008038)2.41182058
141retinal cone cell development (GO:0046549)2.39229978
142genitalia morphogenesis (GO:0035112)2.36670781
143neuron cell-cell adhesion (GO:0007158)2.35417548
144body morphogenesis (GO:0010171)2.35032332
145histone H4-K12 acetylation (GO:0043983)2.34942838
146meiotic nuclear division (GO:0007126)2.33767462
147axon extension (GO:0048675)2.33320922
148regulation of RNA export from nucleus (GO:0046831)2.33260777
149synaptic vesicle maturation (GO:0016188)2.29336871
150cell migration involved in gastrulation (GO:0042074)2.27472390
151neuron projection extension (GO:1990138)2.27047269
152ionotropic glutamate receptor signaling pathway (GO:0035235)2.26732065
153dorsal/ventral axis specification (GO:0009950)2.26312263
154meiotic cell cycle process (GO:1903046)2.26241193
155gastrulation with mouth forming second (GO:0001702)2.23007550
156protein K48-linked deubiquitination (GO:0071108)2.22100826
157developmental cell growth (GO:0048588)2.21871184
158glutamate receptor signaling pathway (GO:0007215)2.21647955
159dendrite morphogenesis (GO:0048813)2.21325132
160cerebral cortex cell migration (GO:0021795)2.21097028
161centriole replication (GO:0007099)2.18957872
162neurofilament cytoskeleton organization (GO:0060052)2.18685432
163embryonic body morphogenesis (GO:0010172)2.18684982
164meiosis I (GO:0007127)2.18656500
165negative regulation of histone methylation (GO:0031061)2.18355571
166microtubule anchoring (GO:0034453)2.18002092
167regulation of synaptic vesicle exocytosis (GO:2000300)2.17416684
168synaptic transmission, glutamatergic (GO:0035249)2.17093031
169gamma-aminobutyric acid transport (GO:0015812)2.14240562
170acrosome assembly (GO:0001675)2.12741107
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.12180344
172central nervous system projection neuron axonogenesis (GO:0021952)2.11498218
173cerebral cortex development (GO:0021987)2.09080428
174meiotic cell cycle (GO:0051321)2.08970794
175cytoplasmic mRNA processing body assembly (GO:0033962)2.08603293
176positive regulation of neurological system process (GO:0031646)2.07808055
177transmission of nerve impulse (GO:0019226)2.05876381
178fat-soluble vitamin biosynthetic process (GO:0042362)11.8077191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34291267
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.34533520
3EZH2_22144423_ChIP-Seq_EOC_Human3.98969179
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.48749125
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40201589
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.22205649
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94993937
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87724382
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.81267560
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69383492
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.68082809
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64045096
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.47331204
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33952996
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.31151046
16EWS_26573619_Chip-Seq_HEK293_Human2.29798227
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29093270
18TAF15_26573619_Chip-Seq_HEK293_Human2.26750763
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23674757
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.13695520
21GBX2_23144817_ChIP-Seq_PC3_Human2.06204960
22* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03318259
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96585400
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94022689
25RNF2_27304074_Chip-Seq_NSC_Mouse1.91101372
26ZNF274_21170338_ChIP-Seq_K562_Hela1.90213399
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86488545
28P300_19829295_ChIP-Seq_ESCs_Human1.85713452
29SMAD4_21799915_ChIP-Seq_A2780_Human1.82645014
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.80198355
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78690601
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73854255
33AR_21572438_ChIP-Seq_LNCaP_Human1.73130390
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72445848
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70848123
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.67280180
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65749209
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64407700
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62094283
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.61736180
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60841274
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60525015
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.60374428
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.58428858
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.57139471
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56868765
47FUS_26573619_Chip-Seq_HEK293_Human1.56112108
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.54587702
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54525669
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52040700
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50362963
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.48400056
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46744850
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45771245
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45188270
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44966996
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44765490
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43334921
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42601866
60AR_21909140_ChIP-Seq_LNCAP_Human1.42160666
61REST_21632747_ChIP-Seq_MESCs_Mouse1.40467319
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39884825
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39884825
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39884825
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38639657
66* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37737326
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37473657
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.37210764
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35628558
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34793561
71VDR_22108803_ChIP-Seq_LS180_Human1.34330826
72RUNX2_22187159_ChIP-Seq_PCA_Human1.32309172
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32225446
74AR_25329375_ChIP-Seq_VCAP_Human1.31464884
75IGF1R_20145208_ChIP-Seq_DFB_Human1.31040423
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.31032554
77TP53_16413492_ChIP-PET_HCT116_Human1.30971611
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.30262271
79* MYC_18940864_ChIP-ChIP_HL60_Human1.29634378
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.27782443
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.27369977
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27134487
83ELK1_19687146_ChIP-ChIP_HELA_Human1.25838441
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25107543
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24703161
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24519080
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24405706
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24011214
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23911812
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.23281826
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21336186
92* TCF4_23295773_ChIP-Seq_U87_Human1.21023539
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.20479171
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20017564
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.18807183
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.17780233
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17561038
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.15707687
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15647153
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.15364804
101CBP_20019798_ChIP-Seq_JUKART_Human1.14977510
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14977510
103BCAT_22108803_ChIP-Seq_LS180_Human1.14947388
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14631573
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14304454
106RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14225497
107ZFX_18555785_Chip-Seq_ESCs_Mouse1.13749842
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13563055
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13015001
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12911069
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12730016
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12269504
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11652930
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09723096
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.09474173
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09006194
117SOX9_26525672_Chip-Seq_HEART_Mouse1.08960091
118P300_18555785_Chip-Seq_ESCs_Mouse1.08512088
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.08487464
120TCF4_18268006_ChIP-ChIP_LS174T_Human1.08286951
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08029925
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07155945
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05690880
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.05645286
125AR_19668381_ChIP-Seq_PC3_Human1.05296121
126JUN_21703547_ChIP-Seq_K562_Human1.04921754
127SMAD4_21741376_ChIP-Seq_HESCs_Human1.04220992
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.04099324
129KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02741937
130EZH2_27304074_Chip-Seq_ESCs_Mouse1.02675923
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02407453
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.01509483
133CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01330637
134TP53_18474530_ChIP-ChIP_U2OS_Human1.01079649
135AHR_22903824_ChIP-Seq_MCF-7_Human1.00779190
136* SMAD3_21741376_ChIP-Seq_ESCs_Human1.00463788
137STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00084227
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00028641
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.99532151
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99422469
141TCF4_22108803_ChIP-Seq_LS180_Human0.99341400
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99111683
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98989715
144OCT4_18555785_Chip-Seq_ESCs_Mouse0.97741143
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.97094540
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96774106
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95886866
148STAT3_23295773_ChIP-Seq_U87_Human0.95514466
149LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95283284
150KLF4_18555785_Chip-Seq_ESCs_Mouse0.93048553
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92409716
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91888209
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90707120
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90707120
155ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90452253
156SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90436467
157CTCF_18555785_Chip-Seq_ESCs_Mouse0.89709687
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89093290
159GF1_26923725_Chip-Seq_HPCs_Mouse0.89075471
160CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89069764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002697_abnormal_eye_size3.94756884
2MP0005377_hearing/vestibular/ear_phenot3.80043353
3MP0003878_abnormal_ear_physiology3.80043353
4MP0008877_abnormal_DNA_methylation3.72406175
5MP0002102_abnormal_ear_morphology3.48901355
6MP0008058_abnormal_DNA_repair3.24918164
7MP0006138_congestive_heart_failure2.99906218
8MP0008007_abnormal_cellular_replicative2.94575971
9MP0004859_abnormal_synaptic_plasticity2.70247526
10MP0010094_abnormal_chromosome_stability2.63688222
11MP0003880_abnormal_central_pattern2.57097659
12MP0003941_abnormal_skin_development2.51528814
13MP0008057_abnormal_DNA_replication2.44215042
14MP0000566_synostosis2.44058051
15MP0000569_abnormal_digit_pigmentation2.37300156
16MP0004270_analgesia2.36707905
17MP0003567_abnormal_fetal_cardiomyocyte2.19577573
18MP0002108_abnormal_muscle_morphology2.17789544
19MP0003943_abnormal_hepatobiliary_system2.17755154
20MP0000778_abnormal_nervous_system2.15291121
21MP0003787_abnormal_imprinting2.13765185
22MP0003111_abnormal_nucleus_morphology2.12900888
23MP0006292_abnormal_olfactory_placode1.93543512
24MP0003693_abnormal_embryo_hatching1.92846828
25MP0003724_increased_susceptibility_to1.91364943
26MP0008995_early_reproductive_senescence1.90239356
27MP0005193_abnormal_anterior_eye1.89565779
28MP0003121_genomic_imprinting1.85516130
29MP0003635_abnormal_synaptic_transmissio1.83839266
30MP0005367_renal/urinary_system_phenotyp1.76918911
31MP0000516_abnormal_urinary_system1.76918911
32MP0001299_abnormal_eye_distance/1.73349088
33MP0005409_darkened_coat_color1.70530673
34MP0003077_abnormal_cell_cycle1.68320367
35MP0001984_abnormal_olfaction1.66974669
36MP0002210_abnormal_sex_determination1.62389256
37MP0000613_abnormal_salivary_gland1.58581301
38MP0000678_abnormal_parathyroid_gland1.58258732
39MP0009046_muscle_twitch1.54101813
40MP0005253_abnormal_eye_physiology1.52469634
41MP0001873_stomach_inflammation1.52024966
42MP0004484_altered_response_of1.52017911
43MP0001145_abnormal_male_reproductive1.51427906
44MP0002063_abnormal_learning/memory/cond1.51113471
45MP0002272_abnormal_nervous_system1.49356828
46MP0003806_abnormal_nucleotide_metabolis1.49307817
47MP0001986_abnormal_taste_sensitivity1.49088526
48MP0001915_intracranial_hemorrhage1.45487400
49MP0006276_abnormal_autonomic_nervous1.43134079
50MP0001119_abnormal_female_reproductive1.42171183
51MP0000653_abnormal_sex_gland1.41611876
52MP0003119_abnormal_digestive_system1.40776751
53MP0004272_abnormal_basement_membrane1.36839700
54MP0005670_abnormal_white_adipose1.36223639
55MP0001286_abnormal_eye_development1.34741312
56MP0009745_abnormal_behavioral_response1.34586793
57MP0001346_abnormal_lacrimal_gland1.33011689
58MP0003123_paternal_imprinting1.28130777
59MP0002734_abnormal_mechanical_nocicepti1.27650415
60MP0000955_abnormal_spinal_cord1.27642051
61MP0002572_abnormal_emotion/affect_behav1.27180423
62MP0003828_pulmonary_edema1.26595012
63MP0002184_abnormal_innervation1.26526015
64MP0001188_hyperpigmentation1.24969196
65MP0004019_abnormal_vitamin_homeostasis1.24710228
66MP0001929_abnormal_gametogenesis1.24445679
67MP0004885_abnormal_endolymph1.23979012
68MP0003718_maternal_effect1.21118381
69MP0004782_abnormal_surfactant_physiolog1.20820850
70MP0002064_seizures1.20769348
71MP0002233_abnormal_nose_morphology1.20728899
72MP0003698_abnormal_male_reproductive1.20350528
73MP0005167_abnormal_blood-brain_barrier1.20313616
74MP0005187_abnormal_penis_morphology1.19129793
75MP0001177_atelectasis1.17982716
76MP0002557_abnormal_social/conspecific_i1.17838597
77MP0002152_abnormal_brain_morphology1.15152359
78MP0003879_abnormal_hair_cell1.13880028
79MP0005076_abnormal_cell_differentiation1.13016784
80MP0001879_abnormal_lymphatic_vessel1.12932344
81MP0000537_abnormal_urethra_morphology1.12075691
82MP0001485_abnormal_pinna_reflex1.11544143
83MP0002882_abnormal_neuron_morphology1.10949570
84MP0002160_abnormal_reproductive_system1.10390513
85MP0002249_abnormal_larynx_morphology1.10274637
86MP0002067_abnormal_sensory_capabilities1.10023159
87MP0002084_abnormal_developmental_patter1.09859542
88MP0010030_abnormal_orbit_morphology1.09616185
89MP0003385_abnormal_body_wall1.09029281
90MP0008789_abnormal_olfactory_epithelium1.08332770
91MP0001293_anophthalmia1.07800844
92MP0002009_preneoplasia1.07131328
93MP0004811_abnormal_neuron_physiology1.06210062
94MP0003935_abnormal_craniofacial_develop1.05653129
95MP0001529_abnormal_vocalization1.04158099
96MP0004133_heterotaxia1.04063076
97MP0003755_abnormal_palate_morphology1.00475278
98MP0005623_abnormal_meninges_morphology0.99077306
99MP0004147_increased_porphyrin_level0.97880186
100MP0005386_behavior/neurological_phenoty0.97184300
101MP0004924_abnormal_behavior0.97184300
102MP0008932_abnormal_embryonic_tissue0.96274744
103MP0001968_abnormal_touch/_nociception0.94287359
104MP0002234_abnormal_pharynx_morphology0.94161731
105MP0002938_white_spotting0.94141051
106MP0004043_abnormal_pH_regulation0.93824953
107MP0009697_abnormal_copulation0.93266583
108MP0000427_abnormal_hair_cycle0.92643005
109MP0005410_abnormal_fertilization0.92369153
110MP0002086_abnormal_extraembryonic_tissu0.90739002
111MP0001440_abnormal_grooming_behavior0.90696267
112MP0006054_spinal_hemorrhage0.89051599
113MP0000631_abnormal_neuroendocrine_gland0.88965411
114MP0001486_abnormal_startle_reflex0.88928855
115MP0002006_tumorigenesis0.88563271
116MP0002085_abnormal_embryonic_tissue0.87953000
117MP0004084_abnormal_cardiac_muscle0.87794161
118MP0002752_abnormal_somatic_nervous0.87069335
119MP0001501_abnormal_sleep_pattern0.86571445
120MP0000383_abnormal_hair_follicle0.86043130
121MP0003890_abnormal_embryonic-extraembry0.84936487
122MP0003786_premature_aging0.84616409
123MP0000432_abnormal_head_morphology0.84137585
124MP0000350_abnormal_cell_proliferation0.84070102
125MP0003315_abnormal_perineum_morphology0.83425333
126MP0003936_abnormal_reproductive_system0.82837111
127MP0000428_abnormal_craniofacial_morphol0.82371079
128MP0003115_abnormal_respiratory_system0.82362698
129MP0005171_absent_coat_pigmentation0.80490014
130MP0002735_abnormal_chemical_nociception0.80202457
131MP0001672_abnormal_embryogenesis/_devel0.79933842
132MP0005380_embryogenesis_phenotype0.79933842
133MP0002925_abnormal_cardiovascular_devel0.79731988
134MP0002066_abnormal_motor_capabilities/c0.79254265
135MP0008569_lethality_at_weaning0.79236693
136MP0002653_abnormal_ependyma_morphology0.79108272
137MP0005391_vision/eye_phenotype0.78753533
138MP0009703_decreased_birth_body0.78693873
139MP0001697_abnormal_embryo_size0.78593605
140MP0000579_abnormal_nail_morphology0.78576041
141MP0002116_abnormal_craniofacial_bone0.78103275
142MP0003937_abnormal_limbs/digits/tail_de0.78041302
143MP0010368_abnormal_lymphatic_system0.76812202
144MP0002161_abnormal_fertility/fecundity0.76328692
145MP0000026_abnormal_inner_ear0.76196034
146MP0004197_abnormal_fetal_growth/weight/0.75537379
147MP0005423_abnormal_somatic_nervous0.75132533
148MP0003656_abnormal_erythrocyte_physiolo0.75121811
149MP0002081_perinatal_lethality0.75072064
150MP0005394_taste/olfaction_phenotype0.74836371
151MP0005499_abnormal_olfactory_system0.74836371
152MP0000534_abnormal_ureter_morphology0.74615454
153MP0001784_abnormal_fluid_regulation0.74187789
154MP0001730_embryonic_growth_arrest0.73392188
155MP0004215_abnormal_myocardial_fiber0.73208518
156MP0003122_maternal_imprinting0.72699552
157MP0003632_abnormal_nervous_system0.72629460
158MP0000470_abnormal_stomach_morphology0.72572766
159MP0005389_reproductive_system_phenotype0.71792546
160MP0010307_abnormal_tumor_latency0.71752623
161MP0001963_abnormal_hearing_physiology0.71730269
162MP0005248_abnormal_Harderian_gland0.69058746
163MP0002396_abnormal_hematopoietic_system0.67905003
164MP0005551_abnormal_eye_electrophysiolog0.67768447
165MP0004957_abnormal_blastocyst_morpholog0.66881834
166MP0003861_abnormal_nervous_system0.66834744
167MP0005385_cardiovascular_system_phenoty0.65798135
168MP0001544_abnormal_cardiovascular_syste0.65798135

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.12667465
2Chromsome breakage (HP:0040012)4.74337369
3Aplasia/Hypoplasia of the spleen (HP:0010451)4.43916197
4Ectopic kidney (HP:0000086)4.13949458
5Birth length less than 3rd percentile (HP:0003561)4.12071731
6Annular pancreas (HP:0001734)3.95400123
7Abnormality of the aortic arch (HP:0012303)3.62285156
8Upper limb muscle weakness (HP:0003484)3.60354776
9Tetany (HP:0001281)3.51827878
10Corneal dystrophy (HP:0001131)3.44819249
11Microretrognathia (HP:0000308)3.39654374
12Volvulus (HP:0002580)3.34439296
13Hypoplasia of the uterus (HP:0000013)3.30872764
14Hyperinsulinemic hypoglycemia (HP:0000825)3.02557684
15Supernumerary spleens (HP:0009799)3.00702634
16Drooling (HP:0002307)2.98446213
17Atonic seizures (HP:0010819)2.90543568
18Congenital cataract (HP:0000519)2.89631436
19Epileptic encephalopathy (HP:0200134)2.89237130
20Small intestinal stenosis (HP:0012848)2.87593010
21Duodenal stenosis (HP:0100867)2.87593010
22Gonadotropin excess (HP:0000837)2.85913160
23Petechiae (HP:0000967)2.79980801
24Focal seizures (HP:0007359)2.77675102
25Esophageal atresia (HP:0002032)2.77366992
26Abnormality of the corticospinal tract (HP:0002492)2.74114416
27Bilateral microphthalmos (HP:0007633)2.70918464
28Papillary thyroid carcinoma (HP:0002895)2.69751629
29Abnormality of the duodenum (HP:0002246)2.66286098
30Excessive salivation (HP:0003781)2.65974661
31Intestinal atresia (HP:0011100)2.64172505
32Impaired vibration sensation in the lower limbs (HP:0002166)2.61067662
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.60145432
34Progressive cerebellar ataxia (HP:0002073)2.59741066
35Focal motor seizures (HP:0011153)2.58365404
36Hyperventilation (HP:0002883)2.56907743
37Aplasia/hypoplasia of the uterus (HP:0008684)2.55133199
38Long clavicles (HP:0000890)2.53503177
39Abnormal pancreas size (HP:0012094)2.53286406
40Abnormality of the labia minora (HP:0012880)2.50853638
41Azoospermia (HP:0000027)2.50716022
42Meckel diverticulum (HP:0002245)2.50498858
43Abnormality of the renal collecting system (HP:0004742)2.50364949
44Abnormality of the lower motor neuron (HP:0002366)2.49553045
45Septo-optic dysplasia (HP:0100842)2.48578020
46Arteriovenous malformation (HP:0100026)2.45092714
47Anterior segment dysgenesis (HP:0007700)2.44802903
48Hepatoblastoma (HP:0002884)2.40391000
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40195275
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.40195275
51Abnormality of chromosome stability (HP:0003220)2.38965267
52Abnormality of the ileum (HP:0001549)2.38331420
53Gaze-evoked nystagmus (HP:0000640)2.37282579
54Abnormal lung lobation (HP:0002101)2.36924928
55Skull defect (HP:0001362)2.36562885
56Urinary bladder sphincter dysfunction (HP:0002839)2.34920228
57Abnormality of the preputium (HP:0100587)2.34528118
58Duplicated collecting system (HP:0000081)2.27418997
59Symptomatic seizures (HP:0011145)2.26156167
60Asplenia (HP:0001746)2.24000564
61Genetic anticipation (HP:0003743)2.23778199
62Hypomagnesemia (HP:0002917)2.23254583
63Gait imbalance (HP:0002141)2.21971370
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21403514
65Action tremor (HP:0002345)2.20975017
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.17109253
67Protruding tongue (HP:0010808)2.16661162
68Pancreatic fibrosis (HP:0100732)2.15806540
69Genital tract atresia (HP:0001827)2.14783361
70Uterine leiomyosarcoma (HP:0002891)2.14691807
71Leiomyosarcoma (HP:0100243)2.14691807
72Gastrointestinal atresia (HP:0002589)2.12982476
73Broad-based gait (HP:0002136)2.12278262
74Abnormal spermatogenesis (HP:0008669)2.06492293
75Amblyopia (HP:0000646)2.06469220
76Oligodactyly (hands) (HP:0001180)2.05806532
77Embryonal renal neoplasm (HP:0011794)2.04466170
78Poor coordination (HP:0002370)2.02603642
79Vaginal atresia (HP:0000148)2.02055012
80Progressive external ophthalmoplegia (HP:0000590)2.01009598
81Abnormal delayed hypersensitivity skin test (HP:0002963)2.00979101
82Nephroblastoma (Wilms tumor) (HP:0002667)2.00969483
83Congenital primary aphakia (HP:0007707)2.00116416
84Nuclear cataract (HP:0100018)10.9657243
85Zonular cataract (HP:0010920)10.0188422
86Medial flaring of the eyebrow (HP:0010747)1.99427321
87Hypoglycemic seizures (HP:0002173)1.98466341
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.96908827
89Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94780267
90Acute myeloid leukemia (HP:0004808)1.94370072
91Intellectual disability, profound (HP:0002187)1.93878899
92Absent eyebrow (HP:0002223)1.91846299
93Impaired vibratory sensation (HP:0002495)1.90699537
94Spastic gait (HP:0002064)1.90364620
95Horseshoe kidney (HP:0000085)1.90311444
96Nephrogenic diabetes insipidus (HP:0009806)1.90041363
97Adactyly (HP:0009776)1.88690542
98Amyotrophic lateral sclerosis (HP:0007354)1.87912872
99Molar tooth sign on MRI (HP:0002419)1.87178888
100Abnormality of midbrain morphology (HP:0002418)1.87178888
101Impulsivity (HP:0100710)1.84797414
102Heterotopia (HP:0002282)1.84502067
103Anophthalmia (HP:0000528)1.82598456
104Abnormal auditory evoked potentials (HP:0006958)1.81672046
105True hermaphroditism (HP:0010459)1.81496466
106Autoimmune thrombocytopenia (HP:0001973)1.80949621
107Chronic hepatic failure (HP:0100626)1.80936364
108Abnormality of the renal medulla (HP:0100957)1.80429364
109Nephronophthisis (HP:0000090)1.80249453
110Small hand (HP:0200055)1.80155192
111Absent radius (HP:0003974)1.79195209
112Aplasia cutis congenita (HP:0001057)1.78450932
113Truncus arteriosus (HP:0001660)1.78374893
114Decreased lacrimation (HP:0000633)1.78087932
115Vertebral arch anomaly (HP:0008438)1.77554530
116Dysdiadochokinesis (HP:0002075)1.77312374
117Absent speech (HP:0001344)1.77311336
118Osteomalacia (HP:0002749)1.76993026
119Dialeptic seizures (HP:0011146)1.76717238
120Gastroesophageal reflux (HP:0002020)1.76437290
121Depressed nasal tip (HP:0000437)1.76219878
122Patellar aplasia (HP:0006443)1.76104645
123Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75078633
124Short foot (HP:0001773)1.75027500
125Transitional cell carcinoma of the bladder (HP:0006740)1.74206339
126Increased nuchal translucency (HP:0010880)1.74112376
127Scapular winging (HP:0003691)1.72953735
128Occipital encephalocele (HP:0002085)1.72478783
129Bicornuate uterus (HP:0000813)1.71699957
130Bronchomalacia (HP:0002780)1.71621652
131Aplasia involving forearm bones (HP:0009822)1.71220322
132Absent forearm bone (HP:0003953)1.71220322
133Breast hypoplasia (HP:0003187)1.70981803
134High anterior hairline (HP:0009890)1.69441307
135Urinary urgency (HP:0000012)1.69413365
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.69196454
137Arterial tortuosity (HP:0005116)1.68621113
138Aplasia of the musculature (HP:0100854)1.68620983
139Pancreatic cysts (HP:0001737)1.67700971
140Neoplasm of the adrenal cortex (HP:0100641)1.66946291
141Diastasis recti (HP:0001540)1.66860538
142Narrow forehead (HP:0000341)1.66172115
143Polyuria (HP:0000103)1.65169157
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64744352
145Tubulointerstitial nephritis (HP:0001970)1.64237001
146Truncal obesity (HP:0001956)1.64002884
147Abnormality of calcium-phosphate metabolism (HP:0100530)1.63433415
148Preaxial foot polydactyly (HP:0001841)1.62851214
149Febrile seizures (HP:0002373)1.62075514
150Clubbing of toes (HP:0100760)1.61689881
151Rib fusion (HP:0000902)1.61414505
152Abnormality of cochlea (HP:0000375)1.60660279
153Short palpebral fissure (HP:0012745)1.60551110
154Labial hypoplasia (HP:0000066)1.60253222
155Abnormality of the nasolacrimal system (HP:0000614)1.60101484
156Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.59955719
157Wide intermamillary distance (HP:0006610)1.59876768
158Absent hand (HP:0004050)1.59191906
159Postural instability (HP:0002172)1.59186259
160Thyroid-stimulating hormone excess (HP:0002925)1.59183243
161Cystic liver disease (HP:0006706)1.57801699
162Breast aplasia (HP:0100783)1.57520324
163Sloping forehead (HP:0000340)1.57438205
164Colon cancer (HP:0003003)1.57246721
165Neoplasm of the oral cavity (HP:0100649)1.56935174
166Capillary hemangiomas (HP:0005306)1.56563963
167Abnormality of ocular smooth pursuit (HP:0000617)1.56447078
168Fair hair (HP:0002286)1.56198142
169Aplasia/Hypoplasia of the patella (HP:0006498)1.55986202
170Pancreatic islet-cell hyperplasia (HP:0004510)1.55931088
171Short thumb (HP:0009778)1.55520881
172Short tibia (HP:0005736)1.55091419
173Absence seizures (HP:0002121)1.55050114
174Abnormal hair whorl (HP:0010721)1.54523432
175Abnormality of the nasal septum (HP:0000419)1.54406158
176Preaxial hand polydactyly (HP:0001177)1.53850890
177Hypoplastic labia majora (HP:0000059)1.53831904
178Bifid tongue (HP:0010297)1.53216386
179Obsessive-compulsive behavior (HP:0000722)1.53159782
180Postaxial hand polydactyly (HP:0001162)1.52850187
181Narrow palate (HP:0000189)1.52402882
182Proximal amyotrophy (HP:0007126)1.52147856
183Lower limb muscle weakness (HP:0007340)1.51825880
184Broad alveolar ridges (HP:0000187)1.51236331
185Cutaneous finger syndactyly (HP:0010554)1.51167678
186Long eyelashes (HP:0000527)1.50607470
187Nasolacrimal duct obstruction (HP:0000579)1.50256847
1882-3 toe syndactyly (HP:0004691)1.49853552
189Shallow orbits (HP:0000586)1.49560171
190Broad palm (HP:0001169)1.49503845
191Abnormality of salivation (HP:0100755)1.48228707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.09365071
2PNCK3.01228009
3GRK12.92600304
4CAMK1D2.91322105
5TEC2.83938054
6BMX2.75161226
7EPHA42.69327197
8MET2.24958285
9CCNB12.19673386
10NTRK32.19602654
11MARK12.10017065
12CAMK1G2.06971474
13TIE113.7741248
14MAP3K91.97822027
15WNK11.96510250
16TSSK61.92342082
17TYRO31.86447797
18TRIM281.82636874
19NTRK21.72602622
20NTRK11.71125337
21BRSK21.68312600
22WNK41.59228578
23FGFR21.52318972
24PAK31.50127681
25KSR11.49979142
26BCR1.46957794
27CDK121.46349256
28ZAK1.45826003
29MST1R1.44547364
30PLK41.39002331
31ERBB41.35795656
32TRPM71.32877609
33CDC71.31839473
34SGK21.24169719
35STK391.23798684
36MKNK21.21403498
37AKT31.20303412
38FRK1.13083781
39BRSK11.12897324
40MKNK11.05024457
41PDGFRA1.04940216
42MINK11.01600144
43WNK31.00259087
44INSRR0.98020018
45PDGFRB0.96243499
46PTK2B0.94652794
47FGFR10.92775936
48ICK0.89225483
49CDK190.88936710
50PTK20.88636440
51TTK0.88203803
52NEK60.84622030
53SGK4940.80208188
54SGK2230.80208188
55IRAK30.79845943
56CDK50.77967657
57SGK30.77156648
58EPHB20.76564222
59STK380.75297857
60STK110.72900743
61MAP2K70.72523250
62SIK20.72429614
63ERBB30.72341809
64CDK80.70398076
65BRD40.70059646
66OXSR10.66911276
67EIF2AK20.66360516
68MARK20.66303760
69DAPK20.65072628
70PLK30.64114342
71CSNK1G10.61278911
72CSNK1G20.60645802
73SCYL20.60226449
74STK38L0.60027676
75VRK10.59822694
76FGFR30.59139458
77PINK10.59097435
78ATR0.58267695
79MELK0.57146973
80PLK10.56148997
81MAP2K20.56073359
82DYRK30.55206294
83CDK70.53790724
84DMPK0.53696142
85PRKD30.53516922
86CAMK2A0.53314953
87DYRK1A0.52092905
88CSNK1E0.51812179
89TAF10.51378591
90FLT30.51274346
91CDK180.50981104
92CHEK20.50376219
93MAP2K40.48892600
94ATM0.48475619
95SGK10.48410771
96ACVR1B0.47843980
97BMPR20.47231459
98PRKCG0.47181490
99STK240.47043116
100PRKCE0.46210324
101CDK30.45970752
102UHMK10.45538468
103CDK150.44903001
104EPHA20.44880466
105CAMK40.44688902
106LATS10.43543847
107PRKCI0.43452053
108PRKDC0.43366575
109MAPK70.43174724
110CAMKK10.43118030
111NLK0.41970377
112PAK60.41867055
113NUAK10.41745941
114MAP3K40.40820027
115CHEK10.40313931
116SIK30.39662032
117MAPK130.39288495
118STK160.38630829
119IRAK40.38370507
120PIK3CA0.37437842
121NEK20.35662823
122PLK20.34332338
123CASK0.33465957
124CDK10.30661725
125NME20.30178453
126LATS20.29074068
127MTOR0.28768195
128YES10.26831235
129TXK0.26548892
130CDK20.26028224
131PASK0.24998849
132MAP3K140.24853563
133KDR0.24767371
134BMPR1B0.23240027
135GSK3B0.22379930
136AURKA0.22154067
137MAPK100.21925039
138AKT20.21384370
139SRPK10.20916354
140ERBB20.20406828
141CLK10.19807475
142WEE10.19616246
143IKBKB0.18561929
144CHUK0.18547295
145TGFBR10.18168520
146MAPK10.17373139
147STK30.17290833
148AKT10.16037627
149CAMK10.15955724
150MAPK90.15028609
151PRKAA20.13506692
152MAP2K60.13056789
153MAP3K30.12370499
154PRKCD0.12260088
155MAPKAPK30.12257777
156MAPK140.12232879
157MAPK80.12039729
158PRKCB0.10898631

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.22246457
2Nicotine addiction_Homo sapiens_hsa050333.13743259
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.86551370
4Cell cycle_Homo sapiens_hsa041102.78345627
5Mismatch repair_Homo sapiens_hsa034302.65944922
6DNA replication_Homo sapiens_hsa030302.58894119
7Basal transcription factors_Homo sapiens_hsa030222.55271383
8Homologous recombination_Homo sapiens_hsa034402.53990140
9Rheumatoid arthritis_Homo sapiens_hsa053232.52162443
10RNA degradation_Homo sapiens_hsa030182.41617166
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35698704
12Ovarian steroidogenesis_Homo sapiens_hsa049132.28724876
13Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.04775709
14HIF-1 signaling pathway_Homo sapiens_hsa040661.95032646
15Glutamatergic synapse_Homo sapiens_hsa047241.93482940
16Adherens junction_Homo sapiens_hsa045201.83607249
17Circadian rhythm_Homo sapiens_hsa047101.76584583
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72583286
19RNA polymerase_Homo sapiens_hsa030201.70486635
20Non-homologous end-joining_Homo sapiens_hsa034501.70052319
21GABAergic synapse_Homo sapiens_hsa047271.67141829
22RNA transport_Homo sapiens_hsa030131.63203146
23Long-term potentiation_Homo sapiens_hsa047201.62023912
24Base excision repair_Homo sapiens_hsa034101.58884063
25Dopaminergic synapse_Homo sapiens_hsa047281.52940013
26Axon guidance_Homo sapiens_hsa043601.52245060
27Nucleotide excision repair_Homo sapiens_hsa034201.50598334
28Insulin secretion_Homo sapiens_hsa049111.48977738
29Amphetamine addiction_Homo sapiens_hsa050311.47434481
30TGF-beta signaling pathway_Homo sapiens_hsa043501.46221052
31Basal cell carcinoma_Homo sapiens_hsa052171.43259107
32Herpes simplex infection_Homo sapiens_hsa051681.39796623
33Lysine degradation_Homo sapiens_hsa003101.36891103
34Spliceosome_Homo sapiens_hsa030401.36837328
35Notch signaling pathway_Homo sapiens_hsa043301.31905022
36Long-term depression_Homo sapiens_hsa047301.31169492
37Purine metabolism_Homo sapiens_hsa002301.30986496
38One carbon pool by folate_Homo sapiens_hsa006701.28690698
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26231285
40Synaptic vesicle cycle_Homo sapiens_hsa047211.25377855
41Bile secretion_Homo sapiens_hsa049761.21641044
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20099962
43HTLV-I infection_Homo sapiens_hsa051661.18708483
44Taste transduction_Homo sapiens_hsa047421.18033416
45Melanogenesis_Homo sapiens_hsa049161.17353889
46ECM-receptor interaction_Homo sapiens_hsa045121.15574899
47Cholinergic synapse_Homo sapiens_hsa047251.15567206
48Cocaine addiction_Homo sapiens_hsa050301.13887295
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12661564
50Wnt signaling pathway_Homo sapiens_hsa043101.11472914
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10349203
52p53 signaling pathway_Homo sapiens_hsa041151.08172630
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08104674
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07787501
55ErbB signaling pathway_Homo sapiens_hsa040121.07066138
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06339885
57Pyrimidine metabolism_Homo sapiens_hsa002401.03502324
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03003187
59Inositol phosphate metabolism_Homo sapiens_hsa005621.02459762
60Hippo signaling pathway_Homo sapiens_hsa043901.02141711
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00783786
62Calcium signaling pathway_Homo sapiens_hsa040201.00634824
63Fructose and mannose metabolism_Homo sapiens_hsa000511.00475057
64Salivary secretion_Homo sapiens_hsa049701.00409886
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99502731
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98692530
67MicroRNAs in cancer_Homo sapiens_hsa052060.98369472
68ABC transporters_Homo sapiens_hsa020100.97791636
69Vitamin B6 metabolism_Homo sapiens_hsa007500.97064690
70cAMP signaling pathway_Homo sapiens_hsa040240.95828071
71Hedgehog signaling pathway_Homo sapiens_hsa043400.94300417
72Regulation of autophagy_Homo sapiens_hsa041400.93226474
73Dorso-ventral axis formation_Homo sapiens_hsa043200.92309523
74Serotonergic synapse_Homo sapiens_hsa047260.92014667
75Morphine addiction_Homo sapiens_hsa050320.90540299
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90345971
77Oxytocin signaling pathway_Homo sapiens_hsa049210.89780808
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.89153554
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87981299
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86895056
81Sphingolipid metabolism_Homo sapiens_hsa006000.85893108
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85860458
83Vitamin digestion and absorption_Homo sapiens_hsa049770.85806129
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84848099
85Oocyte meiosis_Homo sapiens_hsa041140.83689941
86mRNA surveillance pathway_Homo sapiens_hsa030150.81871291
87Rap1 signaling pathway_Homo sapiens_hsa040150.81839145
88Small cell lung cancer_Homo sapiens_hsa052220.81691404
89Propanoate metabolism_Homo sapiens_hsa006400.79591002
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79009338
91Focal adhesion_Homo sapiens_hsa045100.78421592
92Phototransduction_Homo sapiens_hsa047440.77422657
93Gastric acid secretion_Homo sapiens_hsa049710.77057015
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77009208
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76425243
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.74711270
97Colorectal cancer_Homo sapiens_hsa052100.74094476
98Epstein-Barr virus infection_Homo sapiens_hsa051690.73895302
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.73804410
100Prostate cancer_Homo sapiens_hsa052150.73494575
101Renin secretion_Homo sapiens_hsa049240.73153167
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73130722
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72033533
104Glucagon signaling pathway_Homo sapiens_hsa049220.71970185
105Pathways in cancer_Homo sapiens_hsa052000.70742518
106GnRH signaling pathway_Homo sapiens_hsa049120.70694353
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69973730
108Glioma_Homo sapiens_hsa052140.69605853
109Proteoglycans in cancer_Homo sapiens_hsa052050.69306943
110Ras signaling pathway_Homo sapiens_hsa040140.69022838
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68749047
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67515871
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66933104
114FoxO signaling pathway_Homo sapiens_hsa040680.66760300
115Endometrial cancer_Homo sapiens_hsa052130.66038519
116PPAR signaling pathway_Homo sapiens_hsa033200.65642846
117Olfactory transduction_Homo sapiens_hsa047400.64396499
118MAPK signaling pathway_Homo sapiens_hsa040100.64136953
119Fatty acid biosynthesis_Homo sapiens_hsa000610.63398054
120Dilated cardiomyopathy_Homo sapiens_hsa054140.62574707
121Antigen processing and presentation_Homo sapiens_hsa046120.60648612
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59097268
123Choline metabolism in cancer_Homo sapiens_hsa052310.59096020
124Selenocompound metabolism_Homo sapiens_hsa004500.57477275
125Nitrogen metabolism_Homo sapiens_hsa009100.57102304
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55768105
127Steroid biosynthesis_Homo sapiens_hsa001000.53816147
128Influenza A_Homo sapiens_hsa051640.53353426
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53241045
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52674984
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52627472
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.52201208
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.49127514
134Estrogen signaling pathway_Homo sapiens_hsa049150.47237792
135Arachidonic acid metabolism_Homo sapiens_hsa005900.46037681
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44752949
137Mineral absorption_Homo sapiens_hsa049780.43992654
138Allograft rejection_Homo sapiens_hsa053300.40795758
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40557945
140Legionellosis_Homo sapiens_hsa051340.40278731
141Thyroid hormone synthesis_Homo sapiens_hsa049180.40154073
142Tight junction_Homo sapiens_hsa045300.37186990
143Primary immunodeficiency_Homo sapiens_hsa053400.34729608
144Gap junction_Homo sapiens_hsa045400.34284338
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33437057
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33199441
147Ether lipid metabolism_Homo sapiens_hsa005650.31310139
148Circadian entrainment_Homo sapiens_hsa047130.30209247
149Autoimmune thyroid disease_Homo sapiens_hsa053200.29641987
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.29362674

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »