CAPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.99001928
2left/right pattern formation (GO:0060972)8.79460953
3regulation of cilium movement (GO:0003352)7.59469377
4primary alcohol catabolic process (GO:0034310)7.32902822
5left/right axis specification (GO:0070986)6.92032080
6vitamin transmembrane transport (GO:0035461)6.56288413
7ventricular system development (GO:0021591)6.46982872
8one-carbon compound transport (GO:0019755)6.29816947
9ethanol metabolic process (GO:0006067)6.20448238
10microtubule bundle formation (GO:0001578)6.18883595
11cilium organization (GO:0044782)5.95045497
12intraciliary transport (GO:0042073)5.94050216
13diterpenoid biosynthetic process (GO:0016102)5.81153957
14cilium assembly (GO:0042384)5.75222555
15tolerance induction (GO:0002507)5.61951484
16response to xenobiotic stimulus (GO:0009410)5.47287823
17negative regulation of T cell differentiation in thymus (GO:0033085)5.35939532
18lung epithelium development (GO:0060428)5.23566319
19sperm capacitation (GO:0048240)5.17440809
20pyrimidine-containing compound transmembrane transport (GO:0072531)5.06895278
21protein localization to cilium (GO:0061512)5.01358384
22centriole assembly (GO:0098534)4.72872510
23ethanol oxidation (GO:0006069)4.70266997
24negative regulation of immunoglobulin mediated immune response (GO:0002890)4.67369032
25negative regulation of B cell mediated immunity (GO:0002713)4.67369032
26regulation of microtubule-based movement (GO:0060632)4.61053469
27establishment of apical/basal cell polarity (GO:0035089)4.59147964
28cellular component assembly involved in morphogenesis (GO:0010927)4.53405383
29regulation of germinal center formation (GO:0002634)4.47649265
30glomerular epithelial cell development (GO:0072310)4.45425781
31regulation of interleukin-5 production (GO:0032674)4.38729278
32microtubule-based movement (GO:0007018)4.28309137
33negative regulation of humoral immune response (GO:0002921)4.23295620
34cilium morphogenesis (GO:0060271)4.21102642
35cell projection assembly (GO:0030031)4.19680162
36positive regulation of tolerance induction (GO:0002645)4.17514369
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.13587133
38establishment or maintenance of monopolar cell polarity (GO:0061339)4.07204308
39establishment of monopolar cell polarity (GO:0061162)4.07204308
40retinoic acid metabolic process (GO:0042573)4.05849823
41terpenoid biosynthetic process (GO:0016114)4.04945717
42regulation of interleukin-13 production (GO:0032656)4.00440419
43negative regulation of inclusion body assembly (GO:0090084)3.76707113
44nucleoside diphosphate phosphorylation (GO:0006165)3.73855649
45exogenous drug catabolic process (GO:0042738)3.70712474
46cytoplasmic microtubule organization (GO:0031122)3.63160175
47establishment of tissue polarity (GO:0007164)3.44416492
48establishment of planar polarity (GO:0001736)3.44416492
49microtubule depolymerization (GO:0007019)3.38149850
50hydrogen peroxide biosynthetic process (GO:0050665)3.36466320
51regulation of interleukin-6 biosynthetic process (GO:0045408)3.32242915
52primary alcohol metabolic process (GO:0034308)3.25064833
53sperm motility (GO:0030317)3.21266841
54retinol metabolic process (GO:0042572)3.18495722
55lateral ventricle development (GO:0021670)3.17045603
56microtubule polymerization or depolymerization (GO:0031109)3.16684695
57aldehyde catabolic process (GO:0046185)3.16623757
58regulation of tolerance induction (GO:0002643)3.14191138
59O-glycan processing (GO:0016266)3.11787637
60glutathione derivative biosynthetic process (GO:1901687)3.08824041
61glutathione derivative metabolic process (GO:1901685)3.08824041
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01006296
63axonemal dynein complex assembly (GO:0070286)21.2480965
64reactive oxygen species biosynthetic process (GO:1903409)2.99403179
65positive regulation of smoothened signaling pathway (GO:0045880)2.96534053
66drug catabolic process (GO:0042737)2.93123448
67phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.88829611
68lateral sprouting from an epithelium (GO:0060601)2.87603613
69determination of left/right symmetry (GO:0007368)2.86275642
70multicellular organismal water homeostasis (GO:0050891)2.81081620
71regulation of autophagic vacuole assembly (GO:2000785)2.75348810
72determination of bilateral symmetry (GO:0009855)2.70760819
73cornea development in camera-type eye (GO:0061303)2.70362351
74calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69579442
75smoothened signaling pathway (GO:0007224)2.67938062
76excretion (GO:0007588)2.66509054
77carnitine metabolic process (GO:0009437)2.64556240
78specification of symmetry (GO:0009799)2.63558777
79striated muscle atrophy (GO:0014891)2.62336336
80regulation of microtubule depolymerization (GO:0031114)2.61576601
81regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.60130757
82oligosaccharide biosynthetic process (GO:0009312)2.55156448
83ear development (GO:0043583)2.54402000
84apical protein localization (GO:0045176)2.53678694
85phosphatidylcholine biosynthetic process (GO:0006656)2.52333644
86phenol-containing compound catabolic process (GO:0019336)2.52220249
87microtubule-based process (GO:0007017)2.51079918
88mitochondrion degradation (GO:0000422)2.44524469
89organelle assembly (GO:0070925)2.43936375
90water homeostasis (GO:0030104)2.39910038
91progesterone metabolic process (GO:0042448)2.38316140
92renal absorption (GO:0070293)2.37303856
93regulation of cilium assembly (GO:1902017)2.34305413
94protein O-linked glycosylation (GO:0006493)2.33181074
95hydrogen peroxide catabolic process (GO:0042744)2.31790374
96cilium or flagellum-dependent cell motility (GO:0001539)17.4846131
97cilium movement (GO:0003341)15.1874499
98motile cilium assembly (GO:0044458)14.1978874
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.8358913
100epithelial cilium movement (GO:0003351)12.9553765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.30418321
2DROSHA_22980978_ChIP-Seq_HELA_Human3.63111947
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34697993
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.06685242
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.56382842
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.51799626
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.48494097
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31745900
9ESR2_21235772_ChIP-Seq_MCF-7_Human1.96754670
10RUNX1_27514584_Chip-Seq_MCF-7_Human1.87882145
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.87179873
12AHR_22903824_ChIP-Seq_MCF-7_Human1.85491200
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85370228
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83021175
15VDR_22108803_ChIP-Seq_LS180_Human1.81840748
16SMC4_20622854_ChIP-Seq_HELA_Human1.79068990
17STAT1_20625510_ChIP-Seq_HELA_Human1.73531541
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69137367
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65212083
20PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.63923219
21FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.58390448
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58024131
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.55717132
24RAD21_21589869_ChIP-Seq_MESCs_Mouse1.54282914
25* TP63_22573176_ChIP-Seq_HFKS_Human1.51205005
26SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.49390555
27AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48311442
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.47834590
29KLF5_25053715_ChIP-Seq_YYC3_Human1.42466399
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40845266
31* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40513702
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39920442
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38668717
34TP63_23658742_ChIP-Seq_EP156T_Human1.38468646
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38348779
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38029301
37P68_20966046_ChIP-Seq_HELA_Human1.37412529
38SOX2_20726797_ChIP-Seq_SW620_Human1.33567401
39AR_21572438_ChIP-Seq_LNCaP_Human1.32439873
40FOXA1_25552417_ChIP-Seq_VCAP_Human1.31691982
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.30909361
42PHF8_20622854_ChIP-Seq_HELA_Human1.29706446
43ETV1_20927104_ChIP-Seq_GIST48_Human1.28505456
44* ELF1_20517297_ChIP-Seq_JURKAT_Human1.27222341
45CTCF_27219007_Chip-Seq_Bcells_Human1.27083629
46GATA1_19941826_ChIP-Seq_K562_Human1.27008599
47CTCF_20526341_ChIP-Seq_ESCs_Human1.26766302
48SMRT_27268052_Chip-Seq_Bcells_Human1.25534542
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22034412
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19586535
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19321289
52P300_27268052_Chip-Seq_Bcells_Human1.18645267
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15531831
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15404665
55PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15135543
56GATA4_25053715_ChIP-Seq_YYC3_Human1.14037418
57PHF8_20622853_ChIP-Seq_HELA_Human1.13356523
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.12575679
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.12469981
60HNFA_21074721_ChIP-Seq_CACO-2_Human1.11811359
61CREB1_26743006_Chip-Seq_LNCaP_Human1.05994556
62RBPJ_21746931_ChIP-Seq_IB4_Human1.05126912
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.05022074
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04855002
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04621306
66E2F1_20622854_ChIP-Seq_HELA_Human1.04087167
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02938933
68CEBPB_22108803_ChIP-Seq_LS180_Human1.02901200
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.02465996
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01903232
71GATA6_21074721_ChIP-Seq_CACO-2_Human1.00619117
72* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00316786
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99182897
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98188063
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98036693
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97478660
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97167365
78CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96746684
79BCOR_27268052_Chip-Seq_Bcells_Human0.95780840
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95595337
81RACK7_27058665_Chip-Seq_MCF-7_Human0.94870171
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94397803
83TP53_18474530_ChIP-ChIP_U2OS_Human0.94152559
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93411484
85FLI1_21867929_ChIP-Seq_CD8_Mouse0.93042663
86NFYA_21822215_ChIP-Seq_K562_Human0.92294307
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91742519
88MYC_19829295_ChIP-Seq_ESCs_Human0.91710907
89OCT4_20526341_ChIP-Seq_ESCs_Human0.91663146
90FOXA2_19822575_ChIP-Seq_HepG2_Human0.91546313
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91386110
92BCAT_22108803_ChIP-Seq_LS180_Human0.88840571
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88762912
94* SOX2_21211035_ChIP-Seq_LN229_Human0.87937033
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87236652
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87159506
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.86871753
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86871753
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86704765
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.86683052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.85953562
2MP0002653_abnormal_ependyma_morphology6.43671163
3MP0002132_abnormal_respiratory_system5.15482047
4MP0009780_abnormal_chondrocyte_physiolo4.02595104
5MP0001984_abnormal_olfaction3.96555904
6MP0004043_abnormal_pH_regulation3.94773739
7MP0002277_abnormal_respiratory_mucosa3.72557572
8MP0004133_heterotaxia3.49042034
9MP0008789_abnormal_olfactory_epithelium2.72821108
10MP0005623_abnormal_meninges_morphology2.67288415
11MP0000566_synostosis2.50243265
12MP0000383_abnormal_hair_follicle2.45001839
13MP0005377_hearing/vestibular/ear_phenot2.44245204
14MP0003878_abnormal_ear_physiology2.44245204
15MP0002282_abnormal_trachea_morphology2.33349935
16MP0005499_abnormal_olfactory_system2.25495033
17MP0005394_taste/olfaction_phenotype2.25495033
18MP0005083_abnormal_biliary_tract2.12092995
19MP0002160_abnormal_reproductive_system2.02973119
20MP0004019_abnormal_vitamin_homeostasis1.95168036
21MP0003303_peritoneal_inflammation1.91283801
22MP0010678_abnormal_skin_adnexa1.88688410
23MP0001765_abnormal_ion_homeostasis1.71755558
24MP0002168_other_aberrant_phenotype1.71342830
25MP0003656_abnormal_erythrocyte_physiolo1.68239661
26MP0002876_abnormal_thyroid_physiology1.64215466
27MP0002909_abnormal_adrenal_gland1.61478279
28MP0008872_abnormal_physiological_respon1.53763158
29MP0005220_abnormal_exocrine_pancreas1.48656887
30MP0010155_abnormal_intestine_physiology1.43599507
31MP0009379_abnormal_foot_pigmentation1.33835932
32MP0000678_abnormal_parathyroid_gland1.23920233
33MP0005636_abnormal_mineral_homeostasis1.16664912
34MP0001663_abnormal_digestive_system1.13481065
35MP0003866_abnormal_defecation1.13080294
36MP0005389_reproductive_system_phenotype1.12941210
37MP0002249_abnormal_larynx_morphology1.12310813
38MP0009643_abnormal_urine_homeostasis1.10578550
39MP0001502_abnormal_circadian_rhythm1.09936745
40MP0002638_abnormal_pupillary_reflex1.09308640
41MP0001664_abnormal_digestion1.08242656
42MP0001346_abnormal_lacrimal_gland1.06031706
43MP0002734_abnormal_mechanical_nocicepti1.00075827
44MP0002735_abnormal_chemical_nociception0.97896995
45MP0010030_abnormal_orbit_morphology0.97354872
46MP0005365_abnormal_bile_salt0.96503780
47MP0005165_increased_susceptibility_to0.94778942
48MP0005395_other_phenotype0.94477578
49MP0000465_gastrointestinal_hemorrhage0.92922988
50MP0002928_abnormal_bile_duct0.90788073
51MP0002136_abnormal_kidney_physiology0.90685286
52MP0001485_abnormal_pinna_reflex0.86472590
53MP0004264_abnormal_extraembryonic_tissu0.85773543
54MP0005164_abnormal_response_to0.80612051
55MP0000681_abnormal_thyroid_gland0.80157789
56MP0005408_hypopigmentation0.80051251
57MP0004883_abnormal_blood_vessel0.78519257
58MP0001270_distended_abdomen0.78254125
59MP0003136_yellow_coat_color0.77847248
60MP0002405_respiratory_system_inflammati0.77156655
61MP0005381_digestive/alimentary_phenotyp0.76774377
62MP0005248_abnormal_Harderian_gland0.75136637
63MP0001944_abnormal_pancreas_morphology0.73629437
64MP0005646_abnormal_pituitary_gland0.71001482
65MP0009046_muscle_twitch0.69902152
66MP0000026_abnormal_inner_ear0.69053366
67MP0001666_abnormal_nutrient_absorption0.68462133
68MP0003698_abnormal_male_reproductive0.67125045
69MP0003638_abnormal_response/metabolism_0.67020119
70MP0005387_immune_system_phenotype0.64714600
71MP0001790_abnormal_immune_system0.64714600
72MP0009278_abnormal_bone_marrow0.63746657
73MP0005551_abnormal_eye_electrophysiolog0.63523645
74MP0008995_early_reproductive_senescence0.63328356
75MP0002098_abnormal_vibrissa_morphology0.63173286
76MP0002736_abnormal_nociception_after0.62990048
77MP0001929_abnormal_gametogenesis0.62665804
78MP0002233_abnormal_nose_morphology0.62449555
79MP0000858_altered_metastatic_potential0.61534892
80MP0001849_ear_inflammation0.58825558
81MP0005085_abnormal_gallbladder_physiolo0.58422842
82MP0003806_abnormal_nucleotide_metabolis0.56967687
83MP0003195_calcinosis0.54863288
84MP0005253_abnormal_eye_physiology0.52888723
85MP0009703_decreased_birth_body0.51659586
86MP0001970_abnormal_pain_threshold0.50086332
87MP0005310_abnormal_salivary_gland0.49111677
88MP0009765_abnormal_xenobiotic_induced0.48863941
89MP0002229_neurodegeneration0.48459986
90MP0002135_abnormal_kidney_morphology0.48122862
91MP0003938_abnormal_ear_development0.47738466
92MP0001324_abnormal_eye_pigmentation0.47571479
93MP0005076_abnormal_cell_differentiation0.46150935
94MP0001968_abnormal_touch/_nociception0.45643130
95MP0000427_abnormal_hair_cycle0.44576420
96MP0000470_abnormal_stomach_morphology0.43875623
97MP0002822_catalepsy0.43082819
98MP0001293_anophthalmia0.42820530
99MP0006082_CNS_inflammation0.42053461
100MP0001756_abnormal_urination0.41719270

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.99349636
2Chronic bronchitis (HP:0004469)7.68914069
3Bronchiectasis (HP:0002110)7.30643960
4Nasal polyposis (HP:0100582)7.14976982
5Abnormality of the nasal mucosa (HP:0000433)5.96848049
6Recurrent sinusitis (HP:0011108)4.50669753
7Bronchitis (HP:0012387)4.33943305
8Infertility (HP:0000789)4.07076371
9Chronic sinusitis (HP:0011109)4.07023151
10Recurrent otitis media (HP:0000403)3.80145716
11Pancreatic fibrosis (HP:0100732)3.73108194
12Male infertility (HP:0003251)3.62461261
13Occipital encephalocele (HP:0002085)3.56097651
14True hermaphroditism (HP:0010459)3.52109676
15Chronic otitis media (HP:0000389)3.23317596
16Pancreatic cysts (HP:0001737)3.05439397
17Cystic liver disease (HP:0006706)2.96700575
18Hyperactive renin-angiotensin system (HP:0000841)2.95810598
19Abnormality of midbrain morphology (HP:0002418)2.94927374
20Molar tooth sign on MRI (HP:0002419)2.94927374
21Nephronophthisis (HP:0000090)2.92104800
22Atelectasis (HP:0100750)2.84337140
23Chronic hepatic failure (HP:0100626)2.58624901
24Postaxial foot polydactyly (HP:0001830)2.38347893
25Abnormality of the renal medulla (HP:0100957)2.27673844
26Congenital hepatic fibrosis (HP:0002612)2.07224014
27Anencephaly (HP:0002323)2.03860751
28Recurrent bronchitis (HP:0002837)2.03650905
29Male pseudohermaphroditism (HP:0000037)2.02694349
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.02195349
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3961052
32Abnormal respiratory epithelium morphology (HP:0012253)11.1085010
33Abnormal respiratory motile cilium morphology (HP:0005938)11.1085010
34Abnormal respiratory motile cilium physiology (HP:0012261)10.8535560
35Dynein arm defect of respiratory motile cilia (HP:0012255)10.8414620
36Absent/shortened dynein arms (HP:0200106)10.8414620
37Abnormal ciliary motility (HP:0012262)10.6748982
38Bell-shaped thorax (HP:0001591)1.98398167
39Tubular atrophy (HP:0000092)1.95571910
40Decreased circulating renin level (HP:0003351)1.95115316
41Renal salt wasting (HP:0000127)1.91274245
42Aplasia/Hypoplasia of the spleen (HP:0010451)1.89430009
43Asplenia (HP:0001746)1.89150983
44Tubulointerstitial nephritis (HP:0001970)1.88701103
45Medial flaring of the eyebrow (HP:0010747)1.82703536
46Furrowed tongue (HP:0000221)1.71996332
47Sclerocornea (HP:0000647)1.70667550
48Nephropathy (HP:0000112)1.64569320
49Absent frontal sinuses (HP:0002688)1.62095394
50Hyperkalemia (HP:0002153)1.60194417
51Oculomotor apraxia (HP:0000657)1.58960442
52Congenital primary aphakia (HP:0007707)1.57905030
53Gait imbalance (HP:0002141)1.56065890
54Postaxial hand polydactyly (HP:0001162)1.49140133
55Hyperaldosteronism (HP:0000859)1.48089259
56Abnormality of renin-angiotensin system (HP:0000847)1.46174649
57Nephrogenic diabetes insipidus (HP:0009806)1.35453704
58Preaxial hand polydactyly (HP:0001177)1.32818706
59Cone-rod dystrophy (HP:0000548)1.31058919
60Short thorax (HP:0010306)1.30373506
61Abnormality of chloride homeostasis (HP:0011422)1.29218362
62Hypokalemic alkalosis (HP:0001949)1.27077700
63Polydipsia (HP:0001959)1.26781173
64Abnormal drinking behavior (HP:0030082)1.26781173
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.26189264
66Median cleft lip (HP:0000161)1.24149667
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.22376025
68Decreased central vision (HP:0007663)1.22249444
69Stage 5 chronic kidney disease (HP:0003774)1.20486817
70Short femoral neck (HP:0100864)1.20292176
71Disproportionate short-trunk short stature (HP:0003521)1.16879787
72Bile duct proliferation (HP:0001408)1.15557218
73Abnormal biliary tract physiology (HP:0012439)1.15557218
74Tubulointerstitial abnormality (HP:0001969)1.15453614
75Genital tract atresia (HP:0001827)1.13740479
76Hyponatremia (HP:0002902)1.13286017
77Abnormality of the renal cortex (HP:0011035)1.12809452
78Abnormality of permanent molar morphology (HP:0011071)1.12477890
79Abnormality of the dental root (HP:0006486)1.12477890
80Taurodontia (HP:0000679)1.12477890
81Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.10893834
82Hand muscle atrophy (HP:0009130)1.09198523
83Poor coordination (HP:0002370)1.08728930
84Glucose intolerance (HP:0000833)1.07678136
85Fetal akinesia sequence (HP:0001989)1.07652035
86Vaginal atresia (HP:0000148)1.06496359
87Absent speech (HP:0001344)1.03908154
88Abnormality of the dental pulp (HP:0006479)1.03170933
89Bifid scrotum (HP:0000048)1.02701774
90Stridor (HP:0010307)1.02460971
91Abnormality of molar morphology (HP:0011070)1.02090398
92Abnormality of molar (HP:0011077)1.02090398
93Abnormality of the frontal sinuses (HP:0002687)1.02057061
94Aplasia of the musculature (HP:0100854)1.01950134
95Abnormality of the distal phalanges of the toes (HP:0010182)1.01074888
96Spinal muscular atrophy (HP:0007269)0.99808981
97Obstructive sleep apnea (HP:0002870)0.99755948
98Tubulointerstitial fibrosis (HP:0005576)0.98625288
99Abnormality of macular pigmentation (HP:0008002)0.98293734
100Abnormality of the middle phalanges of the toes (HP:0010183)0.97241718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.88698510
2EPHA24.80462252
3INSRR2.93584777
4NME12.58037059
5MAPKAPK32.31121977
6MAP3K22.03872917
7MAPK1511.6495022
8TLK11.73872761
9MAP3K31.61174724
10SMG11.60783271
11STK241.58601228
12CSK1.53450290
13PTK2B1.49591669
14EEF2K1.38261020
15NEK61.19556956
16EPHB11.16789654
17TTK1.13318080
18MAP3K71.10605837
19GRK61.05528056
20TBK11.01407905
21LRRK20.99773510
22RIPK40.97933954
23STK100.92877406
24EPHA30.91400549
25CAMKK10.91009035
26BCR0.90099341
27PRKCI0.87577412
28MARK20.85936676
29TRPM70.85583267
30MST1R0.83229714
31PNCK0.81168822
32RPS6KA20.70868564
33TRIB30.70812791
34GRK10.66956400
35STK380.66579190
36ERBB20.65590048
37PRKCQ0.62436846
38DYRK1B0.62140829
39FRK0.60588865
40HIPK20.55533603
41PDPK10.50285005
42ADRBK20.49160676
43CHUK0.48596718
44TESK10.46524401
45ZAP700.46514805
46OXSR10.43940984
47ADRBK10.43862546
48STK110.43446860
49IKBKE0.43443014
50IRAK10.41222745
51MAP3K110.40944432
52PRKCD0.40939835
53PRKAA20.40718644
54PTK60.40656219
55PRKD30.40343762
56WNK40.40211390
57TAOK10.39474967
58BRSK20.39403446
59MAP3K120.39065343
60ERBB30.39023658
61CDC42BPA0.37640491
62ABL10.36124529
63NLK0.35969825
64SGK10.34960891
65CAMK2G0.34184262
66BMPR1B0.33604620
67RPS6KA60.32953945
68RPS6KB10.32718449
69MAP2K20.32394978
70STK160.32356347
71PRKCZ0.32165204
72CAMKK20.31709290
73ABL20.31357420
74RIPK10.29859267
75PRKCA0.29606333
76MUSK0.28201639
77PRKACA0.28175217
78FYN0.26403420
79ACVR1B0.25971770
80STK390.25663680
81AURKA0.25327382
82ICK0.24981875
83AKT20.24874963
84MAP3K40.24082406
85FGFR30.22937624
86TNK20.21593655
87MAPK130.21380449
88PDK10.20501361
89PRKD20.20245574
90RPS6KC10.20188637
91RPS6KL10.20188637
92MAPKAPK50.19692509
93TYK20.19536599
94MAP2K60.19048979
95RPS6KA50.17614272
96MAPK120.17472401
97SRC0.17396657
98RPS6KB20.17316483
99PASK0.16802347
100MAP2K40.16600187

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.37331088
2Histidine metabolism_Homo sapiens_hsa003404.56944515
3Phenylalanine metabolism_Homo sapiens_hsa003604.42832787
4Chemical carcinogenesis_Homo sapiens_hsa052044.39764404
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.14804861
6Tyrosine metabolism_Homo sapiens_hsa003503.65698406
7beta-Alanine metabolism_Homo sapiens_hsa004102.82377884
8Caffeine metabolism_Homo sapiens_hsa002322.53321400
9Huntingtons disease_Homo sapiens_hsa050162.45416171
10Linoleic acid metabolism_Homo sapiens_hsa005912.41954064
11Retinol metabolism_Homo sapiens_hsa008302.29804518
12Glutathione metabolism_Homo sapiens_hsa004802.22733429
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.13617495
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76933434
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72775321
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70784044
17Sphingolipid metabolism_Homo sapiens_hsa006001.57311941
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.52581864
19ABC transporters_Homo sapiens_hsa020101.49549187
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33631846
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23801513
22Arachidonic acid metabolism_Homo sapiens_hsa005901.20512849
23Peroxisome_Homo sapiens_hsa041461.16450985
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13614480
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12829423
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.10196226
27Tight junction_Homo sapiens_hsa045301.07493073
28Fatty acid degradation_Homo sapiens_hsa000711.03692897
29Salivary secretion_Homo sapiens_hsa049700.97527781
30Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94869156
31Collecting duct acid secretion_Homo sapiens_hsa049660.92978267
32Nitrogen metabolism_Homo sapiens_hsa009100.88956790
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87246129
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83709496
35Drug metabolism - other enzymes_Homo sapiens_hsa009830.82005722
36Notch signaling pathway_Homo sapiens_hsa043300.81190261
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79625692
38Circadian rhythm_Homo sapiens_hsa047100.78872081
39Taste transduction_Homo sapiens_hsa047420.77150744
40Starch and sucrose metabolism_Homo sapiens_hsa005000.77107678
41Butanoate metabolism_Homo sapiens_hsa006500.76878164
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.75337824
43Phototransduction_Homo sapiens_hsa047440.70298608
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68510180
45Hepatitis C_Homo sapiens_hsa051600.67100003
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66956890
47Choline metabolism in cancer_Homo sapiens_hsa052310.62560982
48Olfactory transduction_Homo sapiens_hsa047400.62541011
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58843561
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56517055
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.55240429
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.53311229
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.53062180
54Hematopoietic cell lineage_Homo sapiens_hsa046400.51301189
55Lysosome_Homo sapiens_hsa041420.51300448
56Nicotine addiction_Homo sapiens_hsa050330.51085557
57Ether lipid metabolism_Homo sapiens_hsa005650.49191295
58Cocaine addiction_Homo sapiens_hsa050300.48948749
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.47704404
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45424809
61cAMP signaling pathway_Homo sapiens_hsa040240.42986620
62Hedgehog signaling pathway_Homo sapiens_hsa043400.42661634
63Tryptophan metabolism_Homo sapiens_hsa003800.42306660
64Graft-versus-host disease_Homo sapiens_hsa053320.41743111
65Type I diabetes mellitus_Homo sapiens_hsa049400.38858838
66Basal cell carcinoma_Homo sapiens_hsa052170.38796360
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38447651
68Allograft rejection_Homo sapiens_hsa053300.38180757
69Glycerolipid metabolism_Homo sapiens_hsa005610.37984693
70Autoimmune thyroid disease_Homo sapiens_hsa053200.37779126
71Vitamin digestion and absorption_Homo sapiens_hsa049770.37637148
72Ovarian steroidogenesis_Homo sapiens_hsa049130.37548319
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.35774430
74Metabolic pathways_Homo sapiens_hsa011000.33025629
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30454315
76Calcium signaling pathway_Homo sapiens_hsa040200.29264758
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28543672
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28208980
79PPAR signaling pathway_Homo sapiens_hsa033200.27823111
80Serotonergic synapse_Homo sapiens_hsa047260.27058271
81Asthma_Homo sapiens_hsa053100.26782828
82Complement and coagulation cascades_Homo sapiens_hsa046100.25180390
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.23726979
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23465046
85Amphetamine addiction_Homo sapiens_hsa050310.22177794
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21890359
87Insulin resistance_Homo sapiens_hsa049310.21596231
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20808067
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18973365
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.16658555
91Arginine and proline metabolism_Homo sapiens_hsa003300.16614138
92Bile secretion_Homo sapiens_hsa049760.14925089
93Pancreatic secretion_Homo sapiens_hsa049720.14323512
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14005402
95Staphylococcus aureus infection_Homo sapiens_hsa051500.13465398
96Mineral absorption_Homo sapiens_hsa049780.12520429
97Endocytosis_Homo sapiens_hsa041440.11644656
98Insulin secretion_Homo sapiens_hsa049110.10161263
99Antigen processing and presentation_Homo sapiens_hsa046120.10133897
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08797175

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