CAPS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)5.84028371
2axoneme assembly (GO:0035082)5.52137039
3negative regulation of cytosolic calcium ion concentration (GO:0051481)5.14955678
4motile cilium assembly (GO:0044458)4.58616108
5kinetochore assembly (GO:0051382)4.57943511
6neural tube formation (GO:0001841)4.46305807
7indole-containing compound catabolic process (GO:0042436)4.43069411
8indolalkylamine catabolic process (GO:0046218)4.43069411
9tryptophan catabolic process (GO:0006569)4.43069411
10cilium or flagellum-dependent cell motility (GO:0001539)4.26948210
11G-protein coupled receptor internalization (GO:0002031)4.26445614
12regulation of cilium movement (GO:0003352)4.17600068
13kinetochore organization (GO:0051383)4.17404021
14indolalkylamine metabolic process (GO:0006586)4.09150418
15DNA integration (GO:0015074)4.09052591
16cell wall macromolecule catabolic process (GO:0016998)3.90015831
17cell wall macromolecule metabolic process (GO:0044036)3.90015831
18regulation of non-canonical Wnt signaling pathway (GO:2000050)3.89907972
19intraciliary transport (GO:0042073)3.88692912
20auditory receptor cell stereocilium organization (GO:0060088)3.87226733
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.87066540
22meiotic chromosome segregation (GO:0045132)3.82361595
23centriole assembly (GO:0098534)3.81125584
24microtubule depolymerization (GO:0007019)3.78258008
25regulation of timing of cell differentiation (GO:0048505)3.71362189
26kynurenine metabolic process (GO:0070189)3.70183867
27tryptophan metabolic process (GO:0006568)3.68988903
28regulation of development, heterochronic (GO:0040034)3.60308360
29female gonad development (GO:0008585)3.60118045
30signal peptide processing (GO:0006465)3.56609891
31monoubiquitinated protein deubiquitination (GO:0035520)3.52526931
32microtubule polymerization or depolymerization (GO:0031109)3.52235706
33protein localization to cilium (GO:0061512)3.52159648
34daunorubicin metabolic process (GO:0044597)3.47053306
35polyketide metabolic process (GO:0030638)3.47053306
36doxorubicin metabolic process (GO:0044598)3.47053306
37ventricular system development (GO:0021591)3.44412594
38cilium morphogenesis (GO:0060271)3.43874760
39cellular component assembly involved in morphogenesis (GO:0010927)3.39607926
40preassembly of GPI anchor in ER membrane (GO:0016254)3.39456116
41behavioral response to ethanol (GO:0048149)3.36601414
42reciprocal DNA recombination (GO:0035825)3.36408149
43reciprocal meiotic recombination (GO:0007131)3.36408149
44replicative senescence (GO:0090399)3.35203243
45retinal cone cell development (GO:0046549)3.31135994
46superoxide metabolic process (GO:0006801)3.30700600
47keratinocyte development (GO:0003334)3.30206062
48DNA methylation involved in gamete generation (GO:0043046)3.29337655
49microtubule bundle formation (GO:0001578)3.28379381
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26317035
51inner ear receptor stereocilium organization (GO:0060122)3.23478431
52regulation of helicase activity (GO:0051095)3.22197505
53synapsis (GO:0007129)3.22081584
54benzene-containing compound metabolic process (GO:0042537)3.21223269
55DNA synthesis involved in DNA repair (GO:0000731)3.13692712
56photoreceptor cell maintenance (GO:0045494)3.12666865
57cilium movement (GO:0003341)3.10239524
58indole-containing compound metabolic process (GO:0042430)3.09536750
59regulation of DNA endoreduplication (GO:0032875)3.09511404
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08446648
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.08446648
62regulation of translation, ncRNA-mediated (GO:0045974)3.08446648
63interkinetic nuclear migration (GO:0022027)3.07807932
64spinal cord motor neuron differentiation (GO:0021522)3.07771655
65lateral ventricle development (GO:0021670)3.07639686
66response to X-ray (GO:0010165)3.05694053
67mesenchymal cell differentiation involved in renal system development (GO:2001012)3.04008770
68mesenchymal cell differentiation involved in kidney development (GO:0072161)3.04008770
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03407042
70gamma-aminobutyric acid transport (GO:0015812)3.01815210
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.01588273
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01234277
73DNA strand renaturation (GO:0000733)3.00760081
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00709395
75axonemal dynein complex assembly (GO:0070286)3.00496748
76protein K11-linked deubiquitination (GO:0035871)2.98310417
77membrane depolarization during action potential (GO:0086010)2.96923347
78neuronal action potential (GO:0019228)2.96719924
79regulation of hippo signaling (GO:0035330)2.95532990
80cellular biogenic amine catabolic process (GO:0042402)2.94900736
81amine catabolic process (GO:0009310)2.94900736
82epithelial cilium movement (GO:0003351)2.93944812
83positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91776051
84left/right pattern formation (GO:0060972)2.88749630
85righting reflex (GO:0060013)2.84252120
86negative regulation of keratinocyte proliferation (GO:0010839)2.83487716
87behavioral response to nicotine (GO:0035095)2.81667140
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.80742364
89multicellular organism reproduction (GO:0032504)2.79731246
90cellular response to gamma radiation (GO:0071480)2.77823433
91relaxation of cardiac muscle (GO:0055119)2.76715754
92protein K6-linked ubiquitination (GO:0085020)2.76607193
93intra-S DNA damage checkpoint (GO:0031573)2.76592268
94one-carbon compound transport (GO:0019755)2.73594158
95response to redox state (GO:0051775)2.72115119
96chromatin remodeling at centromere (GO:0031055)2.70926236
97positive regulation of uterine smooth muscle contraction (GO:0070474)2.69555717
98central nervous system neuron axonogenesis (GO:0021955)2.69047979
99histamine secretion (GO:0001821)2.67622891
100cellular ketone body metabolic process (GO:0046950)2.66629088
101protein polyglutamylation (GO:0018095)2.65390445
102regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65372786
103eye photoreceptor cell development (GO:0042462)2.65127288
104detection of light stimulus involved in visual perception (GO:0050908)2.65111239
105detection of light stimulus involved in sensory perception (GO:0050962)2.65111239
106detection of mechanical stimulus involved in sensory perception (GO:0050974)2.64994061
107drug catabolic process (GO:0042737)2.64834879
108cilium assembly (GO:0042384)2.64660746
109calcium ion import (GO:0070509)2.64635777
110oxidative demethylation (GO:0070989)2.64621786
111sperm motility (GO:0030317)2.64310914
112serotonin metabolic process (GO:0042428)2.63876926
113piRNA metabolic process (GO:0034587)2.63562036
114extracellular negative regulation of signal transduction (GO:1900116)2.62178309
115extracellular regulation of signal transduction (GO:1900115)2.62178309
116centriole replication (GO:0007099)2.61819455
117establishment of protein localization to Golgi (GO:0072600)2.61243910
118vascular smooth muscle contraction (GO:0014829)2.60948083
119regulation of keratinocyte proliferation (GO:0010837)2.60685905
120positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.59532626
121positive regulation of odontogenesis (GO:0042482)2.59431089
122cell projection assembly (GO:0030031)2.58621818
123proline transport (GO:0015824)2.57836650
124nonmotile primary cilium assembly (GO:0035058)2.57412518
125tachykinin receptor signaling pathway (GO:0007217)2.55796411
126protein K48-linked deubiquitination (GO:0071108)2.54951303
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.54688663
128cilium organization (GO:0044782)2.54239471
129microtubule-based movement (GO:0007018)2.52137749
130retina layer formation (GO:0010842)2.51827275
131telomere maintenance via telomerase (GO:0007004)2.51389479
132CENP-A containing nucleosome assembly (GO:0034080)2.51080524
133startle response (GO:0001964)2.50976586
134UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50489669
135left/right axis specification (GO:0070986)2.50326019
136ketone body metabolic process (GO:1902224)2.49818488
137regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49100954
138polyol catabolic process (GO:0046174)2.48914899
139regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.48649023
140regulation of skeletal muscle contraction (GO:0014819)2.48602835
141atrial cardiac muscle cell action potential (GO:0086014)2.48041714
142sulfate transmembrane transport (GO:1902358)2.47948298
143response to nitrosative stress (GO:0051409)2.47602155
144presynaptic membrane assembly (GO:0097105)2.47389494
145cytoplasmic microtubule organization (GO:0031122)2.45888559
146thyroid hormone metabolic process (GO:0042403)2.45767155
147reflex (GO:0060004)2.45217649
148determination of left/right symmetry (GO:0007368)2.44634539
149protein-chromophore linkage (GO:0018298)2.44364743
150relaxation of smooth muscle (GO:0044557)2.44218088
151sulfate transport (GO:0008272)2.43562381
152regulation of sarcomere organization (GO:0060297)2.42612920
153cellular response to sterol (GO:0036315)2.42430684
154urinary tract smooth muscle contraction (GO:0014848)2.42175277
155photoreceptor cell development (GO:0042461)2.41899733
156adenosine metabolic process (GO:0046085)2.41722263
157neuronal action potential propagation (GO:0019227)2.41699059
158regulation of collateral sprouting (GO:0048670)2.41125526
159inositol phosphate catabolic process (GO:0071545)2.40753020
160regulation of microtubule-based movement (GO:0060632)2.40320553
161fucose catabolic process (GO:0019317)2.39892829
162L-fucose metabolic process (GO:0042354)2.39892829
163L-fucose catabolic process (GO:0042355)2.39892829
164regulation of gene expression by genetic imprinting (GO:0006349)2.39857734
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38896682
166chromosome organization involved in meiosis (GO:0070192)2.38626485
167GPI anchor biosynthetic process (GO:0006506)2.38488564
168regulation of mitotic spindle checkpoint (GO:1903504)2.38485811
169regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38485811
170histone H3-K9 methylation (GO:0051567)2.37312814
171mismatch repair (GO:0006298)2.36843269
172neural crest cell development (GO:0014032)2.36196454
173cAMP catabolic process (GO:0006198)2.35773714
174vitamin catabolic process (GO:0009111)2.34658018
175fat-soluble vitamin catabolic process (GO:0042363)2.34658018
176serotonin receptor signaling pathway (GO:0007210)2.33699945
177artery smooth muscle contraction (GO:0014824)2.33693125
178positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.31330514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.01150864
2EZH2_22144423_ChIP-Seq_EOC_Human3.37824022
3PCGF2_27294783_Chip-Seq_ESCs_Mouse3.31707670
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.04380599
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88989202
6SUZ12_27294783_Chip-Seq_NPCs_Mouse2.76831451
7PCGF2_27294783_Chip-Seq_NPCs_Mouse2.72813376
8NFE2_27457419_Chip-Seq_LIVER_Mouse2.69311488
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59165913
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48500122
11ZNF274_21170338_ChIP-Seq_K562_Hela2.42799573
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40355803
13EZH2_27294783_Chip-Seq_NPCs_Mouse2.26874058
14EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.19668914
15E2F1_18555785_Chip-Seq_ESCs_Mouse2.13154451
16TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.12433188
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10159426
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09555342
19P53_22387025_ChIP-Seq_ESCs_Mouse2.08999713
20NANOG_18555785_Chip-Seq_ESCs_Mouse2.07328549
21SUZ12_18555785_Chip-Seq_ESCs_Mouse2.05465583
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04691967
23FUS_26573619_Chip-Seq_HEK293_Human1.99833943
24EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.97530945
25STAT3_18555785_Chip-Seq_ESCs_Mouse1.97189781
26NMYC_18555785_Chip-Seq_ESCs_Mouse1.92195932
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.91071650
28OCT4_18555785_Chip-Seq_ESCs_Mouse1.90929300
29CMYC_18555785_Chip-Seq_ESCs_Mouse1.88547379
30P300_18555785_Chip-Seq_ESCs_Mouse1.88137270
31E2F7_22180533_ChIP-Seq_HELA_Human1.80008623
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.78599875
33RUNX1_27457419_Chip-Seq_LIVER_Mouse1.77401253
34SOX2_18555785_Chip-Seq_ESCs_Mouse1.76867807
35BCAT_22108803_ChIP-Seq_LS180_Human1.76525657
36ZFX_18555785_Chip-Seq_ESCs_Mouse1.75625370
37P300_19829295_ChIP-Seq_ESCs_Human1.74081869
38KLF4_18555785_Chip-Seq_ESCs_Mouse1.72221110
39PU1_27457419_Chip-Seq_LIVER_Mouse1.69024745
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67952091
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66430102
42TAF15_26573619_Chip-Seq_HEK293_Human1.66266203
43ESRRB_18555785_Chip-Seq_ESCs_Mouse1.65772025
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.62461721
45CBP_20019798_ChIP-Seq_JUKART_Human1.62191579
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62191579
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61945855
48AR_21572438_ChIP-Seq_LNCaP_Human1.61637198
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.60671157
50IGF1R_20145208_ChIP-Seq_DFB_Human1.60081087
51VDR_22108803_ChIP-Seq_LS180_Human1.60000786
52CTCF_18555785_Chip-Seq_ESCs_Mouse1.59889315
53* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.59064951
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57813479
55EWS_26573619_Chip-Seq_HEK293_Human1.56658250
56SMAD4_21799915_ChIP-Seq_A2780_Human1.55488059
57RNF2_27304074_Chip-Seq_NSC_Mouse1.55412356
58SMAD1_18555785_Chip-Seq_ESCs_Mouse1.55097077
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53872715
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53292289
61* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.52201997
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50083950
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50083950
64* TAL1_26923725_Chip-Seq_HPCs_Mouse1.46994054
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46235585
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44579214
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.42917714
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.42905647
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42846783
70STAT3_23295773_ChIP-Seq_U87_Human1.39922508
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38452547
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.38261957
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37812909
74TCF4_22108803_ChIP-Seq_LS180_Human1.37004818
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35515464
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35479356
77TCF4_23295773_ChIP-Seq_U87_Human1.34767485
78ER_23166858_ChIP-Seq_MCF-7_Human1.34263543
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33600977
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32328640
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32328419
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.31805739
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.31359889
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30520285
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.29990777
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.29634694
87AHR_22903824_ChIP-Seq_MCF-7_Human1.28820395
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28328658
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.27736084
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.26726177
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26617575
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26167878
93NANOG_19829295_ChIP-Seq_ESCs_Human1.26060631
94SOX2_19829295_ChIP-Seq_ESCs_Human1.26060631
95KDM2B_26808549_Chip-Seq_REH_Human1.25320873
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24643877
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24256255
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23578755
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23233436
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23041605
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22753490
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20910296
103CDX2_22108803_ChIP-Seq_LS180_Human1.20283024
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20181912
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.19670980
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18138179
107REST_21632747_ChIP-Seq_MESCs_Mouse1.17094019
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16061720
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14520863
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12363570
111RXR_22108803_ChIP-Seq_LS180_Human1.11456236
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11444178
113* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11217627
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10776605
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10427731
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10073975
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09398146
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09117409
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08141348
120RUNX2_22187159_ChIP-Seq_PCA_Human1.07421118
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06576648
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06419061
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06419061
124TP53_18474530_ChIP-ChIP_U2OS_Human1.06283491
125DROSHA_22980978_ChIP-Seq_HELA_Human1.06281043
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05609929
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05488907
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04207302
129LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01497668
130TP53_22573176_ChIP-Seq_HFKS_Human1.01132405
131AR_25329375_ChIP-Seq_VCAP_Human1.01096607
132TBL1_22424771_ChIP-Seq_293T_Human1.00948571
133* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00821659
134SMAD3_21741376_ChIP-Seq_HESCs_Human1.00253846
135* AR_19668381_ChIP-Seq_PC3_Human1.00132941
136TP53_16413492_ChIP-PET_HCT116_Human0.99933690
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.99665193
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98302947
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97040250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation5.02048779
2MP0006292_abnormal_olfactory_placode3.51092120
3MP0003136_yellow_coat_color3.44894308
4MP0000566_synostosis3.42803436
5MP0003787_abnormal_imprinting3.22354576
6MP0002102_abnormal_ear_morphology3.02878510
7MP0000569_abnormal_digit_pigmentation3.02436428
8MP0003941_abnormal_skin_development2.79032249
9MP0008058_abnormal_DNA_repair2.72391459
10MP0002277_abnormal_respiratory_mucosa2.54411658
11MP0003195_calcinosis2.45259035
12MP0005409_darkened_coat_color2.39407334
13MP0001501_abnormal_sleep_pattern2.32477233
14MP0004043_abnormal_pH_regulation2.31034582
15MP0001984_abnormal_olfaction2.25319103
16MP0000015_abnormal_ear_pigmentation2.21119598
17MP0008877_abnormal_DNA_methylation2.20470656
18MP0002653_abnormal_ependyma_morphology2.15205053
19MP0008004_abnormal_stomach_pH1.98546664
20MP0005551_abnormal_eye_electrophysiolog1.94985037
21MP0005174_abnormal_tail_pigmentation1.92704170
22MP0003646_muscle_fatigue1.90071779
23MP0001986_abnormal_taste_sensitivity1.88986096
24MP0003878_abnormal_ear_physiology1.88982750
25MP0005377_hearing/vestibular/ear_phenot1.88982750
26MP0009697_abnormal_copulation1.78360979
27MP0008875_abnormal_xenobiotic_pharmacok1.78326577
28MP0004084_abnormal_cardiac_muscle1.76317747
29MP0002638_abnormal_pupillary_reflex1.70951832
30MP0005171_absent_coat_pigmentation1.69198800
31MP0010094_abnormal_chromosome_stability1.62172659
32MP0009379_abnormal_foot_pigmentation1.60838885
33MP0001486_abnormal_startle_reflex1.60553737
34MP0002272_abnormal_nervous_system1.60445439
35MP0004381_abnormal_hair_follicle1.59024080
36MP0008995_early_reproductive_senescence1.55004511
37MP0005253_abnormal_eye_physiology1.54980837
38MP0000026_abnormal_inner_ear1.49822181
39MP0002735_abnormal_chemical_nociception1.48793009
40MP0003111_abnormal_nucleus_morphology1.47197023
41MP0000579_abnormal_nail_morphology1.47186945
42MP0000372_irregular_coat_pigmentation1.46601407
43MP0002064_seizures1.46400610
44MP0008872_abnormal_physiological_respon1.45989586
45MP0002734_abnormal_mechanical_nocicepti1.45487986
46MP0005645_abnormal_hypothalamus_physiol1.45074543
47MP0004215_abnormal_myocardial_fiber1.43083497
48MP0005670_abnormal_white_adipose1.42874867
49MP0004145_abnormal_muscle_electrophysio1.42715135
50MP0004133_heterotaxia1.42473375
51MP0005167_abnormal_blood-brain_barrier1.42369301
52MP0002572_abnormal_emotion/affect_behav1.41307699
53MP0001970_abnormal_pain_threshold1.37514445
54MP0006072_abnormal_retinal_apoptosis1.32512218
55MP0004036_abnormal_muscle_relaxation1.28819501
56MP0002249_abnormal_larynx_morphology1.27847101
57MP0002067_abnormal_sensory_capabilities1.27763901
58MP0003693_abnormal_embryo_hatching1.26523234
59MP0003635_abnormal_synaptic_transmissio1.26044111
60MP0003950_abnormal_plasma_membrane1.25536387
61MP0001963_abnormal_hearing_physiology1.25457470
62MP0005410_abnormal_fertilization1.25009913
63MP0010386_abnormal_urinary_bladder1.22600262
64MP0004484_altered_response_of1.21880768
65MP0005646_abnormal_pituitary_gland1.21661269
66MP0002837_dystrophic_cardiac_calcinosis1.20527643
67MP0005386_behavior/neurological_phenoty1.19555563
68MP0004924_abnormal_behavior1.19555563
69MP0003880_abnormal_central_pattern1.19200871
70MP0002928_abnormal_bile_duct1.18706502
71MP0002095_abnormal_skin_pigmentation1.18594172
72MP0000613_abnormal_salivary_gland1.18482981
73MP0008057_abnormal_DNA_replication1.16962422
74MP0000383_abnormal_hair_follicle1.16685490
75MP0003786_premature_aging1.16124396
76MP0002210_abnormal_sex_determination1.16017717
77MP0002822_catalepsy1.15796035
78MP0003698_abnormal_male_reproductive1.15591381
79MP0006276_abnormal_autonomic_nervous1.15438692
80MP0008775_abnormal_heart_ventricle1.15346247
81MP0002168_other_aberrant_phenotype1.14679121
82MP0000049_abnormal_middle_ear1.13888498
83MP0009046_muscle_twitch1.13606727
84MP0000462_abnormal_digestive_system1.12698767
85MP0001346_abnormal_lacrimal_gland1.11585054
86MP0004147_increased_porphyrin_level1.11064164
87MP0002733_abnormal_thermal_nociception1.06560762
88MP0002229_neurodegeneration1.06010910
89MP0009780_abnormal_chondrocyte_physiolo1.05384828
90MP0005257_abnormal_intraocular_pressure1.04974445
91MP0010678_abnormal_skin_adnexa1.04479850
92MP0004085_abnormal_heartbeat1.03921341
93MP0004019_abnormal_vitamin_homeostasis1.02204363
94MP0002138_abnormal_hepatobiliary_system1.02192622
95MP0004742_abnormal_vestibular_system1.01129290
96MP0003633_abnormal_nervous_system1.01038012
97MP0002938_white_spotting1.01030386
98MP0003121_genomic_imprinting1.00616745
99MP0001929_abnormal_gametogenesis1.00482994
100MP0001529_abnormal_vocalization0.96923911
101MP0004859_abnormal_synaptic_plasticity0.96685644
102MP0003938_abnormal_ear_development0.96672904
103MP0002063_abnormal_learning/memory/cond0.96553127
104MP0003011_delayed_dark_adaptation0.96231243
105MP0004142_abnormal_muscle_tone0.96201723
106MP0002163_abnormal_gland_morphology0.96029873
107MP0000490_abnormal_crypts_of0.95266849
108MP0000678_abnormal_parathyroid_gland0.95171012
109MP0004130_abnormal_muscle_cell0.94673222
110MP0002177_abnormal_outer_ear0.94292829
111MP0001968_abnormal_touch/_nociception0.93953320
112MP0002736_abnormal_nociception_after0.91896217
113MP0005248_abnormal_Harderian_gland0.90883400
114MP0005395_other_phenotype0.89414889
115MP0000230_abnormal_systemic_arterial0.88252389
116MP0002752_abnormal_somatic_nervous0.87180625
117MP0001485_abnormal_pinna_reflex0.86499607
118MP0005423_abnormal_somatic_nervous0.86173418
119MP0002876_abnormal_thyroid_physiology0.85767621
120MP0003718_maternal_effect0.85452831
121MP0000470_abnormal_stomach_morphology0.84814323
122MP0002557_abnormal_social/conspecific_i0.84353456
123MP0005085_abnormal_gallbladder_physiolo0.83870261
124MP0002233_abnormal_nose_morphology0.83775307
125MP0005195_abnormal_posterior_eye0.83591844
126MP0003045_fibrosis0.83562743
127MP0003890_abnormal_embryonic-extraembry0.83213887
128MP0005451_abnormal_body_composition0.81460645
129MP0000427_abnormal_hair_cycle0.80766951
130MP0005379_endocrine/exocrine_gland_phen0.80166051
131MP0005266_abnormal_metabolism0.80053496
132MP0000432_abnormal_head_morphology0.79389774
133MP0001661_extended_life_span0.78767730
134MP0002234_abnormal_pharynx_morphology0.78191705
135MP0005391_vision/eye_phenotype0.77925856
136MP0002909_abnormal_adrenal_gland0.76808315
137MP0002132_abnormal_respiratory_system0.76529742
138MP0002160_abnormal_reproductive_system0.76262221
139MP0002127_abnormal_cardiovascular_syste0.75991433
140MP0001119_abnormal_female_reproductive0.75978048
141MP0001324_abnormal_eye_pigmentation0.75871172
142MP0002882_abnormal_neuron_morphology0.75668475
143MP0001502_abnormal_circadian_rhythm0.75644277
144MP0000653_abnormal_sex_gland0.75527631
145MP0003137_abnormal_impulse_conducting0.75247821
146MP0001145_abnormal_male_reproductive0.74768077
147MP0003879_abnormal_hair_cell0.74261439
148MP0003937_abnormal_limbs/digits/tail_de0.74151734
149MP0000538_abnormal_urinary_bladder0.72150368
150MP0000762_abnormal_tongue_morphology0.71896587
151MP0001186_pigmentation_phenotype0.71497230
152MP0000631_abnormal_neuroendocrine_gland0.70721320
153MP0009745_abnormal_behavioral_response0.70158198

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.71814922
2Chromsome breakage (HP:0040012)5.33901554
3Rhinitis (HP:0012384)5.22873877
4Absent/shortened dynein arms (HP:0200106)4.11721403
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.11721403
6Bronchiectasis (HP:0002110)3.91634734
7Abnormality of midbrain morphology (HP:0002418)3.87661387
8Molar tooth sign on MRI (HP:0002419)3.87661387
9Abnormal ciliary motility (HP:0012262)3.78742597
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78178892
11Septo-optic dysplasia (HP:0100842)3.61796775
12Cystic liver disease (HP:0006706)3.59933737
13Febrile seizures (HP:0002373)3.53382786
14Duplicated collecting system (HP:0000081)3.53251720
15Anal stenosis (HP:0002025)3.48593879
16Abnormality of the renal collecting system (HP:0004742)3.44452645
17Chronic bronchitis (HP:0004469)3.41187309
18Tubulointerstitial nephritis (HP:0001970)3.32457280
19Decreased central vision (HP:0007663)3.31509179
20Gaze-evoked nystagmus (HP:0000640)3.29974483
21Aplasia cutis congenita (HP:0001057)3.25009756
22Abnormal respiratory motile cilium physiology (HP:0012261)3.15971234
23Hyperventilation (HP:0002883)3.11502091
24Congenital sensorineural hearing impairment (HP:0008527)3.09482197
25Congenital stationary night blindness (HP:0007642)3.03377013
26Abnormal respiratory motile cilium morphology (HP:0005938)2.95321381
27Abnormal respiratory epithelium morphology (HP:0012253)2.95321381
28Genetic anticipation (HP:0003743)2.94175838
29Renal cortical cysts (HP:0000803)2.92376122
30Central scotoma (HP:0000603)2.89560171
31Upper limb muscle weakness (HP:0003484)2.89285345
32Mesomelia (HP:0003027)2.87093018
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.82675741
34Occipital encephalocele (HP:0002085)2.78593051
35Abnormality of the preputium (HP:0100587)2.78412824
36Progressive cerebellar ataxia (HP:0002073)2.76732000
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.75207462
38Broad-based gait (HP:0002136)2.72014151
39Optic nerve hypoplasia (HP:0000609)2.71499497
40Prostate neoplasm (HP:0100787)2.69950049
41Anencephaly (HP:0002323)2.69182704
42Meckel diverticulum (HP:0002245)2.62539244
43Dyschromatopsia (HP:0007641)2.62027035
44Abnormality of DNA repair (HP:0003254)2.60839491
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.58624310
46Lip pit (HP:0100267)2.58351756
47Nasal polyposis (HP:0100582)2.56576961
48Hip dysplasia (HP:0001385)2.54882305
49Attenuation of retinal blood vessels (HP:0007843)2.49402689
50Duplication of thumb phalanx (HP:0009942)2.47108983
51Congenital hepatic fibrosis (HP:0002612)2.45440559
52Abnormality of the ileum (HP:0001549)2.44874917
53Median cleft lip (HP:0000161)2.44765485
54Chronic hepatic failure (HP:0100626)2.43924075
55Ectopic kidney (HP:0000086)2.43699615
56Furrowed tongue (HP:0000221)2.41974395
57Sclerocornea (HP:0000647)2.41373271
58Abnormality of chromosome stability (HP:0003220)2.38942019
59Decreased circulating renin level (HP:0003351)2.37750448
60Abnormal drinking behavior (HP:0030082)2.35760438
61Polydipsia (HP:0001959)2.35760438
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35740655
63Tubular atrophy (HP:0000092)2.35060445
64Fetal akinesia sequence (HP:0001989)2.33356053
65Osteomalacia (HP:0002749)2.32603034
66Abnormality of the renal cortex (HP:0011035)2.32518527
67Anal atresia (HP:0002023)2.31556132
68Absent speech (HP:0001344)2.30201697
69Abnormality of the nasal septum (HP:0000419)2.29948065
70Abnormality of macular pigmentation (HP:0008002)2.29901910
71Abnormality of the renal medulla (HP:0100957)2.29649072
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26630553
73Facial cleft (HP:0002006)2.25840294
74Genital tract atresia (HP:0001827)2.25046816
75Supernumerary spleens (HP:0009799)2.25044030
76Oligodactyly (hands) (HP:0001180)2.23914863
77Abolished electroretinogram (ERG) (HP:0000550)2.20574171
78Postaxial foot polydactyly (HP:0001830)2.20070764
79Vaginal atresia (HP:0000148)2.18459914
80Spinal muscular atrophy (HP:0007269)2.17441444
81Clubbing of toes (HP:0100760)2.17419507
82Focal seizures (HP:0007359)2.17198671
83Medial flaring of the eyebrow (HP:0010747)2.16569361
84Nasolacrimal duct obstruction (HP:0000579)2.16407766
85Tubulointerstitial abnormality (HP:0001969)2.12025191
86Clumsiness (HP:0002312)2.11318402
87Focal motor seizures (HP:0011153)2.11263356
88Absent septum pellucidum (HP:0001331)2.10748878
89Nephronophthisis (HP:0000090)2.10589997
90Severe visual impairment (HP:0001141)2.10510135
91Abnormality of the septum pellucidum (HP:0007375)2.07718149
92Preaxial hand polydactyly (HP:0001177)2.07038262
93Postaxial hand polydactyly (HP:0001162)2.06942266
94True hermaphroditism (HP:0010459)2.06497208
95Protruding tongue (HP:0010808)2.05442414
96Chronic sinusitis (HP:0011109)2.03990004
97Stenosis of the external auditory canal (HP:0000402)2.02475046
98Hip contracture (HP:0003273)2.01036286
99Abnormality of the carotid arteries (HP:0005344)1.99576930
100Pancreatic cysts (HP:0001737)1.99343382
101Recurrent sinusitis (HP:0011108)1.99023916
102Keratoconus (HP:0000563)1.97754070
103Increased corneal curvature (HP:0100692)1.97754070
104Inability to walk (HP:0002540)1.94577800
105Abnormality of the lacrimal duct (HP:0011481)1.94554239
106Hyperkalemia (HP:0002153)1.94195124
107Poor coordination (HP:0002370)1.91896435
108Microvesicular hepatic steatosis (HP:0001414)1.91876283
109Pancreatic fibrosis (HP:0100732)1.91245220
110Overfolded helix (HP:0000396)1.91084826
111Nephroblastoma (Wilms tumor) (HP:0002667)1.90740140
112Aplasia of the musculature (HP:0100854)1.90739327
113Bile duct proliferation (HP:0001408)1.90316575
114Abnormal biliary tract physiology (HP:0012439)1.90316575
115Dialeptic seizures (HP:0011146)1.90313246
116Bronchitis (HP:0012387)1.89178533
117Progressive inability to walk (HP:0002505)1.88472482
118Disproportionate short-trunk short stature (HP:0003521)1.87564104
119Infertility (HP:0000789)1.87456571
120Scotoma (HP:0000575)1.86561705
121Abnormality of the nasal mucosa (HP:0000433)1.86479699
122Muscle fiber splitting (HP:0003555)1.85841876
123Short thumb (HP:0009778)1.85375972
124Absent radius (HP:0003974)1.85166169
125Hypoplasia of the fovea (HP:0007750)1.84235149
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.84235149
127White forelock (HP:0002211)1.84125559
128Nonprogressive disorder (HP:0003680)1.82827012
129Bony spicule pigmentary retinopathy (HP:0007737)1.82811043
130Distal lower limb muscle weakness (HP:0009053)1.82561731
131Fair hair (HP:0002286)1.82158179
132Male pseudohermaphroditism (HP:0000037)1.82077950
133Small intestinal stenosis (HP:0012848)1.81009167
134Duodenal stenosis (HP:0100867)1.81009167
135Small hand (HP:0200055)1.80107032
136Abnormal rod and cone electroretinograms (HP:0008323)1.79589529
137Triphalangeal thumb (HP:0001199)1.78934375
138Abnormality of the nasolacrimal system (HP:0000614)1.76505144
139Embryonal renal neoplasm (HP:0011794)1.76393408
140Polyuria (HP:0000103)1.75578340
141Abnormality of incisor morphology (HP:0011063)1.75575353
142Intestinal atresia (HP:0011100)1.75328636
143Type II lissencephaly (HP:0007260)1.74414525
144Retinitis pigmentosa (HP:0000510)1.73459402
145Patchy hypopigmentation of hair (HP:0011365)1.73102482
146Aplasia involving forearm bones (HP:0009822)1.73015564
147Absent forearm bone (HP:0003953)1.73015564
148Congenital primary aphakia (HP:0007707)1.71212448
149Nephrogenic diabetes insipidus (HP:0009806)1.71093599
150Stomach cancer (HP:0012126)1.69723492
151Renal agenesis (HP:0000104)1.69463407
152Constricted visual fields (HP:0001133)1.69437768
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69431904
154Astigmatism (HP:0000483)1.68865698
155Birth length less than 3rd percentile (HP:0003561)1.68514883
156Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67948349
157Oculomotor apraxia (HP:0000657)1.67227405
158Alveolar cell carcinoma (HP:0006519)1.63734498
159Abnormality of the parietal bone (HP:0002696)1.63461268
160Abnormality of abdominal situs (HP:0011620)1.63153495
161Abdominal situs inversus (HP:0003363)1.63153495
162Gait imbalance (HP:0002141)1.63153466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.83551295
2EIF2AK23.34760619
3ZAK3.02153864
4BMPR1B2.72569965
5MKNK22.65834245
6INSRR2.54669455
7BLK2.52896833
8ACVR1B2.49943606
9IRAK32.47718938
10TNIK2.38228820
11MAP4K22.28513999
12STK38L2.15899908
13GRK12.02063667
14PIK3CG2.01938852
15CDK122.00222092
16MAP3K41.96978797
17SRPK11.91671229
18AKT31.84682744
19STK391.77440701
20PBK1.75924547
21TXK1.75526208
22IRAK11.73669773
23STK161.72950448
24BRD41.71841389
25MKNK11.69257195
26NUAK11.68944645
27PTK2B1.68643125
28MAP3K71.63041832
29NEK61.52886841
30TTK1.51251208
31CDK31.47554936
32YES11.45775594
33FER1.41252201
34IRAK41.40069101
35MARK11.36294815
36TLK11.28472054
37NTRK31.26158983
38MST41.20278138
39EPHA21.20167874
40FRK1.19767505
41ADRBK21.19160421
42MAP3K141.17999643
43PLK41.17819597
44CAMK1D1.07566123
45ADRBK11.07507319
46TAOK31.03526529
47ATR1.02006994
48BCR0.99603618
49MAP2K70.98926069
50WNK40.95489998
51BMPR20.91938740
52CHEK20.90746627
53DAPK20.90418872
54TEC0.89255538
55IRAK20.88748064
56STK40.88639066
57PNCK0.88051406
58WNK30.86478613
59GRK70.83174316
60EIF2AK30.81991466
61TIE10.79967063
62CAMKK20.79693588
63PAK30.78577591
64VRK10.77600274
65PIK3CA0.77065375
66PLK10.76214757
67MAPK130.75704089
68CAMK1G0.75376683
69PKN10.74410836
70OBSCN0.73938129
71TGFBR10.71466984
72MUSK0.70048623
73CAMK2A0.69889305
74CDK90.68899520
75ERBB30.68898368
76BRSK20.68609771
77LATS10.68338301
78STK30.67745609
79CDC42BPA0.67528029
80TRIM280.66666552
81EPHA30.66143655
82PRKCG0.65750205
83ATM0.65448136
84CDK70.64677484
85SGK20.64121722
86LMTK20.63854812
87STK380.63279570
88CSNK1A1L0.62106281
89PRKCE0.61675137
90PRKAA10.61666918
91NLK0.61291366
92EIF2AK10.61149137
93AURKB0.60652805
94TNK20.59154540
95PRKAA20.58561583
96FGFR20.56556286
97PLK30.56458085
98CAMK10.55634219
99ITK0.55022519
100ERBB40.54770257
101EPHA40.53221398
102PINK10.53154151
103MAPKAPK30.52040325
104CSNK1G20.50933212
105SGK10.50817753
106CLK10.50707063
107PHKG20.49140493
108PHKG10.49140493
109SIK30.48902867
110STK110.48437824
111CDC70.47693829
112PLK20.47406895
113OXSR10.46368951
114PRKACA0.44999379
115JAK10.44843055
116CSNK1G10.44518001
117ERBB20.44400093
118PRKG10.40435960
119CDK80.40023247
120CCNB10.38326938
121CHEK10.38077099
122NME10.38037962
123DYRK1A0.37653101
124MAP2K60.37323436
125MAPK140.36520041
126PRKCA0.36465545
127RPS6KA50.36183869
128IKBKB0.35794733
129MAPK150.35622306
130GSK3B0.35037092
131SGK2230.34385290
132SGK4940.34385290
133AKT10.34088873
134PRKDC0.33881981
135AKT20.33554922
136TRPM70.33243827
137CSNK1D0.32980027
138LYN0.32204587
139CSNK1A10.31982717
140PRKACB0.31218147
141CDK10.30982708
142CAMK40.30952655
143CSNK1G30.30216273
144RPS6KA30.26858976
145PRKCQ0.26807508
146MAP2K40.26736473

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.16177675
2Phototransduction_Homo sapiens_hsa047443.34813689
3Non-homologous end-joining_Homo sapiens_hsa034502.99899046
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71221566
5Homologous recombination_Homo sapiens_hsa034402.64811453
6Butanoate metabolism_Homo sapiens_hsa006502.60762393
7Nicotine addiction_Homo sapiens_hsa050332.43317750
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.32095685
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25122096
10Tryptophan metabolism_Homo sapiens_hsa003802.20291635
11Chemical carcinogenesis_Homo sapiens_hsa052041.98119834
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96285972
13Mismatch repair_Homo sapiens_hsa034301.91346500
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89695805
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.88950357
16Histidine metabolism_Homo sapiens_hsa003401.84125600
17beta-Alanine metabolism_Homo sapiens_hsa004101.83619029
18Nitrogen metabolism_Homo sapiens_hsa009101.82485932
19Taste transduction_Homo sapiens_hsa047421.78892019
20Basal transcription factors_Homo sapiens_hsa030221.70044516
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70020280
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67931305
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66885255
24Propanoate metabolism_Homo sapiens_hsa006401.66242303
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58177904
26Morphine addiction_Homo sapiens_hsa050321.57380464
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.55923901
28Autoimmune thyroid disease_Homo sapiens_hsa053201.50587960
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49717737
30GABAergic synapse_Homo sapiens_hsa047271.44373507
31Sphingolipid metabolism_Homo sapiens_hsa006001.40613613
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.40454830
33Caffeine metabolism_Homo sapiens_hsa002321.36340940
34One carbon pool by folate_Homo sapiens_hsa006701.35510348
35Calcium signaling pathway_Homo sapiens_hsa040201.34249831
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31213172
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27997413
38Glycerolipid metabolism_Homo sapiens_hsa005611.27514054
39Vitamin digestion and absorption_Homo sapiens_hsa049771.27132047
40Purine metabolism_Homo sapiens_hsa002301.27084582
41Basal cell carcinoma_Homo sapiens_hsa052171.22693931
42Dorso-ventral axis formation_Homo sapiens_hsa043201.22310842
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17626524
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16416409
45Arachidonic acid metabolism_Homo sapiens_hsa005901.13634751
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09265347
47Regulation of autophagy_Homo sapiens_hsa041401.08672532
48Hematopoietic cell lineage_Homo sapiens_hsa046401.06359787
49Inositol phosphate metabolism_Homo sapiens_hsa005621.06110072
50Fatty acid degradation_Homo sapiens_hsa000711.04261295
51RNA polymerase_Homo sapiens_hsa030201.04005259
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01319284
53Serotonergic synapse_Homo sapiens_hsa047261.01088684
54Melanoma_Homo sapiens_hsa052180.97888725
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97702894
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96748384
57p53 signaling pathway_Homo sapiens_hsa041150.96564923
58Selenocompound metabolism_Homo sapiens_hsa004500.95969584
59Peroxisome_Homo sapiens_hsa041460.95580821
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.95141562
61Oxytocin signaling pathway_Homo sapiens_hsa049210.94933734
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94301091
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93789097
64Nucleotide excision repair_Homo sapiens_hsa034200.92090619
65Fatty acid biosynthesis_Homo sapiens_hsa000610.91122416
66Allograft rejection_Homo sapiens_hsa053300.89773739
67Renin secretion_Homo sapiens_hsa049240.89655216
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88171129
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87982040
70Retinol metabolism_Homo sapiens_hsa008300.87484794
71Pancreatic secretion_Homo sapiens_hsa049720.87240529
72Pyrimidine metabolism_Homo sapiens_hsa002400.84552179
73Insulin secretion_Homo sapiens_hsa049110.83218007
74Hedgehog signaling pathway_Homo sapiens_hsa043400.81924958
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81889320
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.80620699
77Glutamatergic synapse_Homo sapiens_hsa047240.79751200
78Systemic lupus erythematosus_Homo sapiens_hsa053220.79415342
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79315558
80Gastric acid secretion_Homo sapiens_hsa049710.79238069
81RNA degradation_Homo sapiens_hsa030180.79149362
82mRNA surveillance pathway_Homo sapiens_hsa030150.78327043
83Graft-versus-host disease_Homo sapiens_hsa053320.78196727
84DNA replication_Homo sapiens_hsa030300.77632014
85Circadian entrainment_Homo sapiens_hsa047130.77415924
86Base excision repair_Homo sapiens_hsa034100.75728706
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75410462
88Protein digestion and absorption_Homo sapiens_hsa049740.74747792
89Herpes simplex infection_Homo sapiens_hsa051680.72901447
90Salivary secretion_Homo sapiens_hsa049700.71565411
91Wnt signaling pathway_Homo sapiens_hsa043100.70998055
92ABC transporters_Homo sapiens_hsa020100.70534951
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70431844
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69605524
95cAMP signaling pathway_Homo sapiens_hsa040240.68442363
96Other glycan degradation_Homo sapiens_hsa005110.68274714
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67404063
98Olfactory transduction_Homo sapiens_hsa047400.66555051
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65755640
100Lysine degradation_Homo sapiens_hsa003100.64633815
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64483086
102Cell cycle_Homo sapiens_hsa041100.63913828
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.63478838
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63024285
105Long-term depression_Homo sapiens_hsa047300.62810425
106Circadian rhythm_Homo sapiens_hsa047100.62538439
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61960052
108Asthma_Homo sapiens_hsa053100.60279609
109ECM-receptor interaction_Homo sapiens_hsa045120.60249810
110Dopaminergic synapse_Homo sapiens_hsa047280.60196348
111Measles_Homo sapiens_hsa051620.60134887
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59812342
113Huntingtons disease_Homo sapiens_hsa050160.57693247
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57559611
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.56995333
116TNF signaling pathway_Homo sapiens_hsa046680.56914034
117Mineral absorption_Homo sapiens_hsa049780.55176476
118Rheumatoid arthritis_Homo sapiens_hsa053230.53438102
119Glutathione metabolism_Homo sapiens_hsa004800.52374713
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52355874
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50819496
122Dilated cardiomyopathy_Homo sapiens_hsa054140.50580972
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.49758620
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49608290
125Spliceosome_Homo sapiens_hsa030400.49567989
126Tyrosine metabolism_Homo sapiens_hsa003500.48515991
127Steroid biosynthesis_Homo sapiens_hsa001000.48116487
128Axon guidance_Homo sapiens_hsa043600.47811426
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47049853
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44827235
131Cocaine addiction_Homo sapiens_hsa050300.44191105
132Ras signaling pathway_Homo sapiens_hsa040140.43779485
133Fatty acid metabolism_Homo sapiens_hsa012120.43019091
134Ether lipid metabolism_Homo sapiens_hsa005650.42720452
135Cholinergic synapse_Homo sapiens_hsa047250.41941319
136Bile secretion_Homo sapiens_hsa049760.41816138
137Malaria_Homo sapiens_hsa051440.41430778
138Pathways in cancer_Homo sapiens_hsa052000.40744844
139Primary immunodeficiency_Homo sapiens_hsa053400.40544068
140Starch and sucrose metabolism_Homo sapiens_hsa005000.40307991
141Linoleic acid metabolism_Homo sapiens_hsa005910.40074131
142Amphetamine addiction_Homo sapiens_hsa050310.39919860
143Type II diabetes mellitus_Homo sapiens_hsa049300.39695357
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.39633719
145Metabolic pathways_Homo sapiens_hsa011000.39257681
146Type I diabetes mellitus_Homo sapiens_hsa049400.39168460
147Ovarian steroidogenesis_Homo sapiens_hsa049130.38771225
148MicroRNAs in cancer_Homo sapiens_hsa052060.37567052
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36110222
150African trypanosomiasis_Homo sapiens_hsa051430.35322656
151Fat digestion and absorption_Homo sapiens_hsa049750.34158717
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33028785
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.31824342
154Tight junction_Homo sapiens_hsa045300.27987730

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