CAPZA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.51858922
2DNA double-strand break processing (GO:0000729)4.92419604
3DNA deamination (GO:0045006)4.91139801
4cullin deneddylation (GO:0010388)4.54230141
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28998726
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28998726
7protein deneddylation (GO:0000338)4.12238728
8antigen processing and presentation of endogenous antigen (GO:0019883)4.10969748
9synapsis (GO:0007129)4.09298844
10positive regulation of gamma-delta T cell activation (GO:0046645)4.04058866
11lactate metabolic process (GO:0006089)4.00466484
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.98615415
13leukocyte aggregation (GO:0070486)3.98501287
14replication fork processing (GO:0031297)3.94289011
15protein K6-linked ubiquitination (GO:0085020)3.89746108
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.83286972
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81325129
18signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.77994800
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.77994800
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.77994800
21platelet dense granule organization (GO:0060155)3.75174362
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.75102821
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.75102821
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74767179
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74059137
26regulation of DNA endoreduplication (GO:0032875)3.73212946
27respiratory chain complex IV assembly (GO:0008535)3.72889075
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.72616888
29positive regulation of protein autophosphorylation (GO:0031954)3.68608723
30chromatin remodeling at centromere (GO:0031055)3.66451370
31regulation of B cell receptor signaling pathway (GO:0050855)3.65717093
32somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.61654828
33isotype switching (GO:0045190)3.61654828
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.61654828
35CENP-A containing nucleosome assembly (GO:0034080)3.59876937
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56446732
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.56446732
38negative regulation of phagocytosis (GO:0050765)3.56049894
39regulation of cellular amino acid metabolic process (GO:0006521)3.55548548
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.55009249
41histone exchange (GO:0043486)3.54012818
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.53788525
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45133136
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41792602
45DNA catabolic process, exonucleolytic (GO:0000738)3.40724653
46neutrophil activation involved in immune response (GO:0002283)3.35803359
47signal peptide processing (GO:0006465)3.33804016
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32927548
49positive regulation of glycoprotein biosynthetic process (GO:0010560)3.32711338
50negative regulation of ligase activity (GO:0051352)3.29264730
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29264730
52keratinocyte development (GO:0003334)3.24355641
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23310976
54DNA strand elongation involved in DNA replication (GO:0006271)3.22734872
55cytochrome complex assembly (GO:0017004)3.21659736
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19575529
57recombinational repair (GO:0000725)3.18437859
58double-strand break repair via homologous recombination (GO:0000724)3.18238126
59ribosomal small subunit assembly (GO:0000028)3.16666888
60regulation of interleukin-12 biosynthetic process (GO:0045075)3.16121559
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13461898
62positive regulation of ligase activity (GO:0051351)3.11651045
63interferon-gamma production (GO:0032609)3.10133262
64attachment of spindle microtubules to kinetochore (GO:0008608)3.08604512
65DNA strand elongation (GO:0022616)3.08560076
66prenylation (GO:0097354)3.08127198
67protein prenylation (GO:0018342)3.08127198
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08058359
69immunoglobulin mediated immune response (GO:0016064)3.06505285
70telomere maintenance via semi-conservative replication (GO:0032201)3.05457067
71cellular response to zinc ion (GO:0071294)3.03183342
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02099251
73non-recombinational repair (GO:0000726)3.01735389
74double-strand break repair via nonhomologous end joining (GO:0006303)3.01735389
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.00592508
76negative T cell selection (GO:0043383)2.97695296
77DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.96990152
78water-soluble vitamin biosynthetic process (GO:0042364)2.96987768
79rRNA methylation (GO:0031167)2.96345745
80resolution of meiotic recombination intermediates (GO:0000712)2.94757137
81negative thymic T cell selection (GO:0045060)2.93136744
82DNA replication-dependent nucleosome assembly (GO:0006335)2.92058877
83DNA replication-dependent nucleosome organization (GO:0034723)2.92058877
84DNA unwinding involved in DNA replication (GO:0006268)2.90974990
85maturation of 5.8S rRNA (GO:0000460)2.90727063
86positive regulation of cell cycle arrest (GO:0071158)2.90148438
87defense response to protozoan (GO:0042832)2.89567925
88telomere maintenance via recombination (GO:0000722)2.89180231
89histone mRNA catabolic process (GO:0071044)2.89169257
90regulation of meiosis I (GO:0060631)2.88890805
91histone mRNA metabolic process (GO:0008334)2.87791441
92female gonad development (GO:0008585)2.86806210
93T cell migration (GO:0072678)2.86005201
94response to X-ray (GO:0010165)2.85035831
95response to protozoan (GO:0001562)2.84573752
96response to pheromone (GO:0019236)2.84509495
97rRNA modification (GO:0000154)2.83865896
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.83699159
99positive regulation of B cell differentiation (GO:0045579)2.82369288
100regulation of gamma-delta T cell differentiation (GO:0045586)2.82252774
101regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.82048791
102regulation of B cell differentiation (GO:0045577)2.80919053
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80202219
104regulation of mitotic spindle checkpoint (GO:1903504)2.80202219
105positive regulation of glycoprotein metabolic process (GO:1903020)2.79639989
106ribosome assembly (GO:0042255)2.79528044
107respiratory burst (GO:0045730)2.79449637
108mitochondrial DNA replication (GO:0006264)2.79314610
109B cell mediated immunity (GO:0019724)2.78246736
110actin nucleation (GO:0045010)2.77947602
111postreplication repair (GO:0006301)2.76478230
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76338521
113regulation of ligase activity (GO:0051340)2.75633789
114cytidine deamination (GO:0009972)2.75369349
115cytidine metabolic process (GO:0046087)2.75369349
116cytidine catabolic process (GO:0006216)2.75369349
117spindle checkpoint (GO:0031577)2.74459003
118mitotic recombination (GO:0006312)2.73778814
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.73753856
120myeloid dendritic cell activation (GO:0001773)2.72952629
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72265491
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72265491
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.72265491
124B cell receptor signaling pathway (GO:0050853)2.70937085
125positive regulation of isotype switching (GO:0045830)2.70776039
126UDP-N-acetylglucosamine metabolic process (GO:0006047)2.70096599
127branched-chain amino acid catabolic process (GO:0009083)2.66461459
128protein localization to kinetochore (GO:0034501)2.66263048
129cellular extravasation (GO:0045123)2.66142849
130regulation of gamma-delta T cell activation (GO:0046643)2.65778148
131regulation of protein autophosphorylation (GO:0031952)2.65002913
132positive regulation of interferon-alpha production (GO:0032727)2.63968298
133double-strand break repair (GO:0006302)2.63594642
134histone H2A acetylation (GO:0043968)2.62753217
135regulation of Rac protein signal transduction (GO:0035020)2.62682420
136sequestering of actin monomers (GO:0042989)2.62381519
137protein neddylation (GO:0045116)2.61607500
138purine nucleobase biosynthetic process (GO:0009113)2.61557114
139neutrophil activation (GO:0042119)2.60870925
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58999031
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57186029
142mitotic chromosome condensation (GO:0007076)2.57019253
143regulation of response to interferon-gamma (GO:0060330)2.56862632
144DNA replication initiation (GO:0006270)2.56240082
145NIK/NF-kappaB signaling (GO:0038061)2.54548092
146regulation of interferon-alpha production (GO:0032647)2.54130273
147mast cell activation (GO:0045576)2.54074449
148hepatocyte apoptotic process (GO:0097284)2.53325471
149regulation of interferon-beta biosynthetic process (GO:0045357)2.52617613
150response to peptidoglycan (GO:0032494)2.52168081
151modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51195125
152positive regulation by organism of defense response of other organism involved in symbiotic interact2.51195125
153modulation by symbiont of host immune response (GO:0052553)2.51195125
154positive regulation by symbiont of host defense response (GO:0052509)2.51195125
155modulation by symbiont of host defense response (GO:0052031)2.51195125
156modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51195125
157regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.50446257
158cellular response to interferon-beta (GO:0035458)2.49086514
159negative regulation of growth of symbiont in host (GO:0044130)2.49086182
160negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.49086182
161modulation of growth of symbiont involved in interaction with host (GO:0044144)2.49086182
162regulation of growth of symbiont in host (GO:0044126)2.49086182
163positive thymic T cell selection (GO:0045059)2.48633049
164regulation of alpha-beta T cell proliferation (GO:0046640)2.47774278
165leukocyte cell-cell adhesion (GO:0007159)2.47639005
166pinocytosis (GO:0006907)2.47562155
167interferon-gamma-mediated signaling pathway (GO:0060333)2.43074998
168response to type I interferon (GO:0034340)2.42642110
169kinetochore organization (GO:0051383)2.42326896
170cellular response to type I interferon (GO:0071357)2.41608535
171type I interferon signaling pathway (GO:0060337)2.41608535
172granulocyte activation (GO:0036230)2.41460088
173positive regulation of macrophage differentiation (GO:0045651)2.39941396
174natural killer cell mediated cytotoxicity (GO:0042267)2.39730120
175natural killer cell mediated immunity (GO:0002228)2.39730120
176protein localization to chromosome, centromeric region (GO:0071459)2.39702906
177regulation of T cell receptor signaling pathway (GO:0050856)2.37988347
178positive regulation of alpha-beta T cell proliferation (GO:0046641)2.37670160
179response to interleukin-15 (GO:0070672)2.37492136
180nucleotide-excision repair, DNA gap filling (GO:0006297)2.37403997
181mitotic nuclear envelope disassembly (GO:0007077)2.35979355
182neutrophil mediated immunity (GO:0002446)2.32883729
183antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.32826334
184regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32277629
185leukocyte mediated cytotoxicity (GO:0001909)2.30733252
186cellular response to interleukin-15 (GO:0071350)2.29976423
187formation of translation preinitiation complex (GO:0001731)2.29205602
188regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.29183801
189telomere maintenance via telomere lengthening (GO:0010833)2.28375517
190establishment of chromosome localization (GO:0051303)2.27320250
191T cell homeostasis (GO:0043029)2.26290754
192antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.25779100
193positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.25621702
194regulation of necroptotic process (GO:0060544)2.25484056
195nuclear pore complex assembly (GO:0051292)2.25448228
196myeloid dendritic cell differentiation (GO:0043011)2.25178128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.57225920
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.89257915
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.59013766
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.42554085
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.24587249
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.15161506
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07217809
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02150867
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.92825559
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90725940
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78299489
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67324067
13* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65989828
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64898506
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.56039922
16VDR_22108803_ChIP-Seq_LS180_Human2.50002841
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49946964
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47572162
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40289040
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.40176796
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38285899
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30432486
23* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27058427
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.21312423
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.13517074
26EWS_26573619_Chip-Seq_HEK293_Human2.13081038
27MYC_22102868_ChIP-Seq_BL_Human2.11881000
28ZNF274_21170338_ChIP-Seq_K562_Hela2.11724880
29* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11187549
30* SPI1_23547873_ChIP-Seq_NB4_Human2.08902336
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03919597
32* MYB_26560356_Chip-Seq_TH2_Human2.02708183
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01108826
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.00976152
35IRF8_27001747_Chip-Seq_BMDM_Mouse2.00147183
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99861940
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.96098958
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93989925
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93905938
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92872606
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89253812
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88054241
43* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87455917
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87029847
45FUS_26573619_Chip-Seq_HEK293_Human1.85146623
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83603384
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82134678
48VDR_21846776_ChIP-Seq_THP-1_Human1.81981366
49VDR_23849224_ChIP-Seq_CD4+_Human1.81133285
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75483639
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.75310523
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72762570
53* P300_19829295_ChIP-Seq_ESCs_Human1.72266608
54MYB_26560356_Chip-Seq_TH1_Human1.72263863
55* MAF_26560356_Chip-Seq_TH1_Human1.67274232
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66554941
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66461290
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66311582
59* ELK1_19687146_ChIP-ChIP_HELA_Human1.62419547
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.61282754
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60410315
62FOXP3_21729870_ChIP-Seq_TREG_Human1.59770211
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57902394
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57550006
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57010212
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55993576
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.53833252
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.53572856
69SCL_19346495_ChIP-Seq_HPC-7_Human1.52609097
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50771018
71* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49831457
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49589725
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49295891
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49058085
75* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48723948
76IGF1R_20145208_ChIP-Seq_DFB_Human1.47643602
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47420750
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46262960
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.46078487
80* UTX_26944678_Chip-Seq_JUKART_Human1.45915082
81VDR_24763502_ChIP-Seq_THP-1_Human1.43778163
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43580431
83RUNX_20019798_ChIP-Seq_JUKART_Human1.39520284
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.38320996
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36991755
86XRN2_22483619_ChIP-Seq_HELA_Human1.36605862
87AR_21909140_ChIP-Seq_LNCAP_Human1.36159575
88ER_23166858_ChIP-Seq_MCF-7_Human1.35670995
89CIITA_25753668_ChIP-Seq_RAJI_Human1.34472090
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33772693
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33207562
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33144749
93MYC_18940864_ChIP-ChIP_HL60_Human1.31322911
94DCP1A_22483619_ChIP-Seq_HELA_Human1.30644728
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30419494
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29760888
97GBX2_23144817_ChIP-Seq_PC3_Human1.27102146
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27028899
99* SOX2_19829295_ChIP-Seq_ESCs_Human1.25393337
100* NANOG_19829295_ChIP-Seq_ESCs_Human1.25393337
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25247148
102TAF15_26573619_Chip-Seq_HEK293_Human1.23691246
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20038237
104BCAT_22108803_ChIP-Seq_LS180_Human1.19781001
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19494891
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18977723
107CDX2_22108803_ChIP-Seq_LS180_Human1.18768729
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18762177
109TFEB_21752829_ChIP-Seq_HELA_Human1.18669733
110GABP_19822575_ChIP-Seq_HepG2_Human1.18017271
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.17532426
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16945451
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16763246
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16021414
115P300_18555785_Chip-Seq_ESCs_Mouse1.15454995
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15393809
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15365218
118P53_22387025_ChIP-Seq_ESCs_Mouse1.15287558
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13870814
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13596379
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13305946
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12103692
123NOTCH1_21737748_ChIP-Seq_TLL_Human1.11912183
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.11328322
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10601213
126* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10582225
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10448000
128PU_27001747_Chip-Seq_BMDM_Mouse1.09659738
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09050586
130GATA3_27048872_Chip-Seq_THYMUS_Human1.09010918
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.07990261
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.07288346
133E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06710726
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06076933
135MAF_26560356_Chip-Seq_TH2_Human1.06068065
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05784907
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05424521
138CBP_20019798_ChIP-Seq_JUKART_Human1.05424521
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04405207
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03191185
141OCT4_18555785_Chip-Seq_ESCs_Mouse1.02813412
142* TTF2_22483619_ChIP-Seq_HELA_Human1.02738495
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02309219
144* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01562611
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.01379691
146SMAD3_21741376_ChIP-Seq_EPCs_Human1.00975052
147CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00639025
148FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00636695
149FOXA1_25329375_ChIP-Seq_VCAP_Human1.00636695
150SRF_21415370_ChIP-Seq_HL-1_Mouse1.00549414
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00395754
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99807319
153TCF4_22108803_ChIP-Seq_LS180_Human0.99665853
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99558192
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99394552
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.98716795
157KDM5A_27292631_Chip-Seq_BREAST_Human0.98615026
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98483225
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97966185
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97866590
161* SALL4_22934838_ChIP-ChIP_CD34+_Human0.97444528
162GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97211228
163CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97106142
164SPI1_23127762_ChIP-Seq_K562_Human0.94506255
165LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93777912
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93092543
167* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91946674
168CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89931446
169* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89773657
170GATA3_26560356_Chip-Seq_TH2_Human0.89740459
171HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88307983
172TCF7_22412390_ChIP-Seq_EML_Mouse0.86826797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.56403903
2MP0001835_abnormal_antigen_presentation3.92300100
3MP0002102_abnormal_ear_morphology3.59234702
4MP0005671_abnormal_response_to3.11482379
5MP0009785_altered_susceptibility_to3.02901783
6MP0003195_calcinosis2.95491946
7MP0002396_abnormal_hematopoietic_system2.82260789
8MP0003950_abnormal_plasma_membrane2.72244796
9MP0003436_decreased_susceptibility_to2.71347298
10MP0003763_abnormal_thymus_physiology2.69159158
11MP0000685_abnormal_immune_system2.57632287
12MP0005000_abnormal_immune_tolerance2.57402538
13MP0001800_abnormal_humoral_immune2.56073729
14MP0002148_abnormal_hypersensitivity_rea2.47812062
15MP0002452_abnormal_antigen_presenting2.45043703
16MP0002420_abnormal_adaptive_immunity2.37260334
17MP0005025_abnormal_response_to2.36285275
18MP0001819_abnormal_immune_cell2.35018499
19MP0003693_abnormal_embryo_hatching2.33725645
20MP0009697_abnormal_copulation2.32254046
21MP0010094_abnormal_chromosome_stability2.30218356
22MP0009333_abnormal_splenocyte_physiolog2.28875255
23MP0002419_abnormal_innate_immunity2.28795330
24MP0002723_abnormal_immune_serum2.28567083
25MP0001790_abnormal_immune_system2.27729301
26MP0005387_immune_system_phenotype2.27729301
27MP0002398_abnormal_bone_marrow2.27215802
28MP0003806_abnormal_nucleotide_metabolis2.27154472
29MP0005408_hypopigmentation2.16894386
30MP0006054_spinal_hemorrhage2.15383229
31MP0010234_abnormal_vibrissa_follicle2.10355650
32MP0002405_respiratory_system_inflammati2.06709872
33MP0008057_abnormal_DNA_replication2.03975131
34MP0003077_abnormal_cell_cycle2.01084354
35MP0000716_abnormal_immune_system1.98273164
36MP0004808_abnormal_hematopoietic_stem1.95183209
37MP0003303_peritoneal_inflammation1.93055509
38MP0003724_increased_susceptibility_to1.92881235
39MP0003718_maternal_effect1.90818351
40MP0002938_white_spotting1.90513826
41MP0005171_absent_coat_pigmentation1.90023669
42MP0002166_altered_tumor_susceptibility1.89619627
43MP0000689_abnormal_spleen_morphology1.88521637
44MP0002722_abnormal_immune_system1.84793778
45MP0006082_CNS_inflammation1.84491271
46MP0001853_heart_inflammation1.82521865
47MP0003111_abnormal_nucleus_morphology1.81427878
48MP0008007_abnormal_cellular_replicative1.77337235
49MP0002429_abnormal_blood_cell1.77203035
50MP0005464_abnormal_platelet_physiology1.77019342
51MP0002006_tumorigenesis1.73845386
52MP0010155_abnormal_intestine_physiology1.73484720
53MP0006036_abnormal_mitochondrial_physio1.70496217
54MP0010307_abnormal_tumor_latency1.70140215
55MP0004957_abnormal_blastocyst_morpholog1.67892977
56MP0000490_abnormal_crypts_of1.66691041
57MP0000703_abnormal_thymus_morphology1.63617394
58MP0010352_gastrointestinal_tract_polyps1.61740455
59MP0002090_abnormal_vision1.61198992
60MP0001545_abnormal_hematopoietic_system1.61169741
61MP0005397_hematopoietic_system_phenotyp1.61169741
62MP0000858_altered_metastatic_potential1.59680084
63MP0000516_abnormal_urinary_system1.59607856
64MP0005367_renal/urinary_system_phenotyp1.59607856
65MP0002163_abnormal_gland_morphology1.58587088
66MP0001873_stomach_inflammation1.56957928
67MP0000427_abnormal_hair_cycle1.55313022
68MP0006072_abnormal_retinal_apoptosis1.52200948
69MP0001845_abnormal_inflammatory_respons1.51563263
70MP0000465_gastrointestinal_hemorrhage1.50558797
71MP0003448_altered_tumor_morphology1.49192746
72MP0002254_reproductive_system_inflammat1.48915491
73MP0008058_abnormal_DNA_repair1.45391820
74MP0005084_abnormal_gallbladder_morpholo1.44819551
75MP0001533_abnormal_skeleton_physiology1.42739588
76MP0004947_skin_inflammation1.39704173
77MP0005253_abnormal_eye_physiology1.34801224
78MP0005379_endocrine/exocrine_gland_phen1.28896681
79MP0002019_abnormal_tumor_incidence1.28730635
80MP0002933_joint_inflammation1.28613351
81MP0000371_diluted_coat_color1.23798563
82MP0005395_other_phenotype1.21189984
83MP0002837_dystrophic_cardiac_calcinosis1.20475465
84MP0004381_abnormal_hair_follicle1.20297106
85MP0009278_abnormal_bone_marrow1.19916546
86MP0003300_gastrointestinal_ulcer1.18941010
87MP0003866_abnormal_defecation1.17046704
88MP0002751_abnormal_autonomic_nervous1.13204425
89MP0001324_abnormal_eye_pigmentation1.11777308
90MP0001119_abnormal_female_reproductive1.11399024
91MP0006035_abnormal_mitochondrial_morpho1.08370072
92MP0008469_abnormal_protein_level1.06629226
93MP0000343_altered_response_to1.06273648
94MP0000647_abnormal_sebaceous_gland1.04719934
95MP0002282_abnormal_trachea_morphology1.03102237
96MP0008872_abnormal_physiological_respon1.00602740
97MP0001929_abnormal_gametogenesis0.98552353
98MP0005058_abnormal_lysosome_morphology0.98144445
99MP0000350_abnormal_cell_proliferation0.96897199
100MP0005174_abnormal_tail_pigmentation0.96345325
101MP0005076_abnormal_cell_differentiation0.96120875
102MP0000613_abnormal_salivary_gland0.96119488
103MP0010678_abnormal_skin_adnexa0.95170099
104MP0005023_abnormal_wound_healing0.93849402
105MP0003172_abnormal_lysosome_physiology0.93124899
106MP0005551_abnormal_eye_electrophysiolog0.92467306
107MP0003566_abnormal_cell_adhesion0.91009005
108MP0000313_abnormal_cell_death0.90199704
109MP0008875_abnormal_xenobiotic_pharmacok0.90089790
110MP0004215_abnormal_myocardial_fiber0.89899294
111MP0000358_abnormal_cell_content/0.88987915
112MP0005389_reproductive_system_phenotype0.88630413
113MP0003787_abnormal_imprinting0.88372059
114MP0008932_abnormal_embryonic_tissue0.87404189
115MP0000569_abnormal_digit_pigmentation0.85295139
116MP0002168_other_aberrant_phenotype0.84661498
117MP0001730_embryonic_growth_arrest0.84093407
118MP0000653_abnormal_sex_gland0.84077928
119MP0001485_abnormal_pinna_reflex0.82932984
120MP0004484_altered_response_of0.82462794
121MP0000015_abnormal_ear_pigmentation0.82138557
122MP0003183_abnormal_peptide_metabolism0.81671881
123MP0009764_decreased_sensitivity_to0.80902978
124MP0003828_pulmonary_edema0.79301326
125MP0005310_abnormal_salivary_gland0.78855412
126MP0005075_abnormal_melanosome_morpholog0.78750583
127MP0002095_abnormal_skin_pigmentation0.77329487
128MP0002210_abnormal_sex_determination0.77188186
129MP0002132_abnormal_respiratory_system0.76347521
130MP0008995_early_reproductive_senescence0.76336212
131MP0004510_myositis0.75893237
132MP0003252_abnormal_bile_duct0.75798916
133MP0003786_premature_aging0.74858499
134MP0003186_abnormal_redox_activity0.74613180
135MP0005332_abnormal_amino_acid0.72887750
136MP0001764_abnormal_homeostasis0.72832877
137MP0003890_abnormal_embryonic-extraembry0.72366944
138MP0001851_eye_inflammation0.72043824
139MP0003943_abnormal_hepatobiliary_system0.71902675
140MP0004147_increased_porphyrin_level0.71332845
141MP0001915_intracranial_hemorrhage0.71040931
142MP0003137_abnormal_impulse_conducting0.70281351
143MP0001697_abnormal_embryo_size0.69670382
144MP0005390_skeleton_phenotype0.69575238
145MP0001293_anophthalmia0.69365783
146MP0008877_abnormal_DNA_methylation0.68370060
147MP0002075_abnormal_coat/hair_pigmentati0.67589615
148MP0002998_abnormal_bone_remodeling0.67209638
149MP0000749_muscle_degeneration0.66881779
150MP0001145_abnormal_male_reproductive0.66609977
151MP0003646_muscle_fatigue0.64483313
152MP0010386_abnormal_urinary_bladder0.63812111
153MP0003937_abnormal_limbs/digits/tail_de0.63560334
154MP0003941_abnormal_skin_development0.62014229
155MP0003795_abnormal_bone_structure0.60356730
156MP0002876_abnormal_thyroid_physiology0.59785990
157MP0001984_abnormal_olfaction0.59551609
158MP0001919_abnormal_reproductive_system0.59474557
159MP0003279_aneurysm0.58660713
160MP0005187_abnormal_penis_morphology0.58566770
161MP0002160_abnormal_reproductive_system0.58429862
162MP0001186_pigmentation_phenotype0.57843169
163MP0009763_increased_sensitivity_to0.57447600
164MP0001661_extended_life_span0.57274214
165MP0003656_abnormal_erythrocyte_physiolo0.56848422
166MP0000249_abnormal_blood_vessel0.56802047
167MP0005645_abnormal_hypothalamus_physiol0.56550669
168MP0001663_abnormal_digestive_system0.55789995
169MP0004782_abnormal_surfactant_physiolog0.55510812
170MP0002080_prenatal_lethality0.53897881
171MP0003984_embryonic_growth_retardation0.53427681

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.76002733
2Eczematoid dermatitis (HP:0000976)4.47668381
3Elevated erythrocyte sedimentation rate (HP:0003565)4.12174249
4Myositis (HP:0100614)3.99379450
5Recurrent bacterial skin infections (HP:0005406)3.96753484
6Thrombocytosis (HP:0001894)3.83864242
7Recurrent viral infections (HP:0004429)3.61615371
8Recurrent bronchitis (HP:0002837)3.57713845
9T lymphocytopenia (HP:0005403)3.57609976
10Abnormality of T cell number (HP:0011839)3.55472712
11Recurrent fungal infections (HP:0002841)3.48940085
12IgM deficiency (HP:0002850)3.48161200
13Chronic obstructive pulmonary disease (HP:0006510)3.39040004
14Obstructive lung disease (HP:0006536)3.39040004
15Neoplasm of the adrenal cortex (HP:0100641)3.31090757
16Chronic otitis media (HP:0000389)3.25906346
17Abnormality of T cells (HP:0002843)3.23083056
18Abnormality of chromosome stability (HP:0003220)3.23051424
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20931115
20Mediastinal lymphadenopathy (HP:0100721)3.17299679
21Orchitis (HP:0100796)3.07377190
22Meningitis (HP:0001287)3.05724629
23Retrobulbar optic neuritis (HP:0100654)3.05317509
24Optic neuritis (HP:0100653)3.05317509
25Neoplasm of the adrenal gland (HP:0100631)3.03592848
26Meckel diverticulum (HP:0002245)3.03122957
27Hypothermia (HP:0002045)3.02087853
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.00837728
29Progressive macrocephaly (HP:0004481)2.97471556
30Abnormality of the ileum (HP:0001549)2.94582364
31Eosinophilia (HP:0001880)2.93136947
32Cellulitis (HP:0100658)2.90978143
33IgG deficiency (HP:0004315)2.90357550
34Intestinal atresia (HP:0011100)2.89184334
35Increased CSF lactate (HP:0002490)2.87701726
36Abnormality of B cell number (HP:0010975)2.86381598
37B lymphocytopenia (HP:0010976)2.86381598
38Acute necrotizing encephalopathy (HP:0006965)2.85317940
39Vasculitis (HP:0002633)2.83584076
40Acute encephalopathy (HP:0006846)2.83384960
41Petechiae (HP:0000967)2.82755316
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.80359299
43Hypoplasia of the fovea (HP:0007750)2.80359299
44Recurrent gram-negative bacterial infections (HP:0005420)2.76594794
45Abnormality of T cell physiology (HP:0011840)2.76348742
46Autoimmune thrombocytopenia (HP:0001973)2.73968515
47Recurrent skin infections (HP:0001581)2.72740381
48Combined immunodeficiency (HP:0005387)2.71897511
49Abnormality of macrophages (HP:0004311)2.69077899
50Granulocytopenia (HP:0001913)2.68863723
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68546588
52Severe combined immunodeficiency (HP:0004430)2.67771273
53Leukocytosis (HP:0001974)2.67339042
54Stomatitis (HP:0010280)2.65529215
55Abnormality of the preputium (HP:0100587)2.64734794
56Small intestinal stenosis (HP:0012848)2.64502441
57Duodenal stenosis (HP:0100867)2.64502441
58Lymphopenia (HP:0001888)2.64130513
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.61991556
60Abnormality of eosinophils (HP:0001879)2.61336461
61Mitochondrial inheritance (HP:0001427)2.60583836
62Ependymoma (HP:0002888)2.59137438
63Abnormality of methionine metabolism (HP:0010901)2.56213958
64Lymphoma (HP:0002665)2.54714683
65Volvulus (HP:0002580)2.54046802
66Abnormality of the duodenum (HP:0002246)2.53957699
67Nasal polyposis (HP:0100582)2.53109855
68Recurrent cutaneous fungal infections (HP:0011370)2.51375592
69Chronic mucocutaneous candidiasis (HP:0002728)2.51375592
70Pancreatic cysts (HP:0001737)2.50558548
71Thyroiditis (HP:0100646)2.48502287
72Spontaneous hematomas (HP:0007420)2.46959805
73Albinism (HP:0001022)2.46733183
74Abnormal lung lobation (HP:0002101)2.46608490
75Abnormality of the fovea (HP:0000493)2.44872609
76Pulmonary infiltrates (HP:0002113)2.44455125
77Periodontitis (HP:0000704)2.44197670
78Abnormality of the anterior horn cell (HP:0006802)2.41011876
79Degeneration of anterior horn cells (HP:0002398)2.41011876
80Abnormality of the prostate (HP:0008775)2.40999863
81IgA deficiency (HP:0002720)2.39726553
82Chronic diarrhea (HP:0002028)2.39635244
83Hepatocellular necrosis (HP:0001404)2.38265935
84Methylmalonic acidemia (HP:0002912)2.36595827
85Recurrent pneumonia (HP:0006532)2.36556099
86Clubbing of toes (HP:0100760)2.36246066
87Osteomyelitis (HP:0002754)2.35736867
88Gingivitis (HP:0000230)2.35685316
89Aplastic anemia (HP:0001915)2.34919926
90Keratoconjunctivitis sicca (HP:0001097)2.33396695
91Hypoproteinemia (HP:0003075)2.33326870
92Hemoptysis (HP:0002105)2.33304895
93Increased hepatocellular lipid droplets (HP:0006565)2.32810083
94Breast carcinoma (HP:0003002)2.31760089
95Colon cancer (HP:0003003)2.30810511
96Agammaglobulinemia (HP:0004432)2.29030959
97Congenital stationary night blindness (HP:0007642)2.28639759
98Hypergammaglobulinemia (HP:0010702)2.26775078
99Hamartoma of the eye (HP:0010568)2.26077136
100Pustule (HP:0200039)2.25186047
101Cutaneous melanoma (HP:0012056)2.24560641
102Panhypogammaglobulinemia (HP:0003139)2.22902869
103Pancreatic fibrosis (HP:0100732)2.22272954
104Abnormal mitochondria in muscle tissue (HP:0008316)2.21711315
105Pancreatic islet-cell hyperplasia (HP:0004510)2.21099764
106Abnormality of the nasal mucosa (HP:0000433)2.20744969
107Agnosia (HP:0010524)2.20645361
108Arterial thrombosis (HP:0004420)2.19159623
109Pulmonary fibrosis (HP:0002206)2.18509476
110Skin ulcer (HP:0200042)2.18168073
111Aplasia/Hypoplasia of the macula (HP:0008059)2.17518321
112Tongue fasciculations (HP:0001308)2.16943228
113Interstitial pulmonary disease (HP:0006530)2.16894931
114Reticulocytopenia (HP:0001896)2.16227570
115Recurrent sinusitis (HP:0011108)2.13610321
116Hepatic necrosis (HP:0002605)2.13029669
117Keratoconjunctivitis (HP:0001096)2.12271667
118Glioma (HP:0009733)2.11687640
119Supernumerary spleens (HP:0009799)2.11408212
120Encephalitis (HP:0002383)2.10162740
121Inflammation of the large intestine (HP:0002037)2.09929441
122Cerebral edema (HP:0002181)2.08790458
123Conjunctival hamartoma (HP:0100780)2.08420874
124Recurrent lower respiratory tract infections (HP:0002783)2.07825705
125Gastrointestinal inflammation (HP:0004386)2.07268286
126Lipid accumulation in hepatocytes (HP:0006561)2.07261044
127Abnormal delayed hypersensitivity skin test (HP:0002963)2.06215328
128Increased IgM level (HP:0003496)2.05987860
129Amaurosis fugax (HP:0100576)2.05059936
130Abnormality of the labia minora (HP:0012880)2.04175497
131Abnormality of the astrocytes (HP:0100707)2.03143748
132Astrocytoma (HP:0009592)2.03143748
133Chest pain (HP:0100749)2.02844221
134Autoimmune hemolytic anemia (HP:0001890)2.02566968
135Disproportionate short-trunk short stature (HP:0003521)2.02304641
136True hermaphroditism (HP:0010459)2.01603639
137Chronic sinusitis (HP:0011109)2.00893756
138Bronchitis (HP:0012387)2.00494764
139Myelodysplasia (HP:0002863)2.00257685
140Sloping forehead (HP:0000340)1.99833438
141Aplasia/Hypoplasia affecting the retina (HP:0008061)1.99603418
142Vacuolated lymphocytes (HP:0001922)1.97431641
143Increased serum lactate (HP:0002151)1.97234294
144Abnormality of the pleura (HP:0002103)1.96637672
145Abnormality of glycolysis (HP:0004366)1.94947609
146Molar tooth sign on MRI (HP:0002419)1.93353900
147Abnormality of midbrain morphology (HP:0002418)1.93353900
14811 pairs of ribs (HP:0000878)1.93005129
149Gastrointestinal infarctions (HP:0005244)1.92634107
150Congenital, generalized hypertrichosis (HP:0004540)1.92529796
151Basal ganglia calcification (HP:0002135)1.91628125
152Aqueductal stenosis (HP:0002410)1.90076406
153Methylmalonic aciduria (HP:0012120)1.90035384
154Chromsome breakage (HP:0040012)1.89369390
155Sepsis (HP:0100806)1.89005456
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.88958313
157Prostate neoplasm (HP:0100787)1.88793484
158Poikiloderma (HP:0001029)1.87760048
159Exertional dyspnea (HP:0002875)1.87457983
160Type I transferrin isoform profile (HP:0003642)1.87112626
161Birth length less than 3rd percentile (HP:0003561)1.86745076
162Small hand (HP:0200055)1.86508811
163Dyschromatopsia (HP:0007641)1.86421053
164Gastrointestinal stroma tumor (HP:0100723)1.85727284
165Papilloma (HP:0012740)1.85648405
166Verrucae (HP:0200043)1.85648405
167Abnormal platelet volume (HP:0011876)1.85270038
168Rhabdomyosarcoma (HP:0002859)1.82683847
169Increased serum pyruvate (HP:0003542)1.81234723
170Renal Fanconi syndrome (HP:0001994)1.78724323
171Abnormality of vitamin B metabolism (HP:0004340)1.78339166
172Stillbirth (HP:0003826)1.77543668
173Embryonal renal neoplasm (HP:0011794)1.75998876
174Muscle fibrillation (HP:0010546)1.75702882
175Nephroblastoma (Wilms tumor) (HP:0002667)1.74089605
176Hematochezia (HP:0002573)1.72703830
177Lethargy (HP:0001254)1.72548350
178Ovarian neoplasm (HP:0100615)1.72357916
179Sensory axonal neuropathy (HP:0003390)1.72208159
180Patchy hypopigmentation of hair (HP:0011365)1.70142487
181Meningioma (HP:0002858)1.68662910
182Iris hypopigmentation (HP:0007730)1.67703451
183Respiratory failure (HP:0002878)1.67670442
184Neoplasm of the colon (HP:0100273)1.67054644
185Bifid tongue (HP:0010297)1.66916093
186Median cleft lip (HP:0000161)1.66897042
187Abnormal glycosylation (HP:0012345)1.66006233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.05121332
2MAP4K13.80880858
3FRK3.48314906
4TXK3.23785560
5MKNK22.88209933
6IRAK42.56494426
7EIF2AK12.56330011
8BUB12.27160644
9PLK22.25355228
10MAP3K142.25267367
11CDC72.19738972
12BMPR1B2.19375986
13STK102.17553939
14JAK32.15562226
15BLK2.10528863
16ZAP701.94345751
17TEC1.92855497
18TBK11.91751501
19TYK21.90984895
20BCR1.87587070
21PIM21.84861673
22TESK21.82509547
23BTK1.82165320
24WNK31.79308828
25KIT1.77017927
26STK391.73998983
27VRK21.64906653
28ITK1.61516286
29TESK11.60556258
30BRSK21.57892853
31WEE11.55369023
32CLK11.52797315
33MAP4K21.51919955
34NEK21.50346279
35IKBKE1.49605597
36NEK91.48696920
37TNIK1.45008022
38RPS6KA41.42330776
39SYK1.41609988
40OXSR11.37957650
41TAF11.37304448
42ACVR1B1.35393844
43EIF2AK31.32022184
44MST41.28237572
45CSF1R1.28139381
46LRRK21.24675241
47PIM11.23152016
48TGFBR11.21383343
49EEF2K1.17370851
50MAP3K121.15807352
51IKBKB1.15748506
52KDR1.15288928
53GRK11.15186786
54LCK1.14717662
55SRPK11.13043894
56PKN21.10072040
57NME21.09064905
58TSSK61.08875951
59JAK11.06231924
60PAK31.06073955
61PAK41.05308478
62ATR1.03845614
63CSK1.02757156
64LYN1.02690259
65STK40.99714239
66FER0.96055083
67TTK0.95168217
68MAP2K30.94020088
69FGFR20.92913469
70HCK0.92686467
71FLT30.91139209
72CSNK1G10.89852631
73GRK60.89086717
74SIK30.87864132
75PLK40.86808855
76PASK0.83796878
77STK160.81753675
78STK38L0.81661812
79FGFR30.80857453
80VRK10.80414217
81MAP3K80.80191713
82MARK30.79684442
83BMPR20.79275086
84CDK40.78913260
85SCYL20.78622362
86PDK20.77566675
87CSNK1G30.77349306
88TRPM70.76950172
89BRSK10.76923567
90CHUK0.76330945
91RPS6KB20.74742152
92NUAK10.74686429
93AURKB0.73815483
94CSNK1G20.73803119
95INSRR0.73506998
96MKNK10.73385470
97ADRBK20.73053674
98TGFBR20.72624744
99ERN10.71846053
100MAP3K100.71061960
101FGFR40.69333624
102EIF2AK20.66922417
103PLK10.65840370
104MAPK130.63026593
105STK240.61770108
106IRAK30.59984464
107FES0.59181477
108CCNB10.59057479
109STK30.57594993
110CDK70.56950818
111ERBB30.56631009
112EPHB10.55835192
113MAPKAPK20.54506738
114CSNK1A1L0.52366527
115NLK0.51369962
116PLK30.51045141
117PRKCE0.49983977
118TAOK30.48915093
119LIMK10.47860737
120CDK60.47777148
121MAPKAPK50.47324929
122MYLK0.47062800
123TRIB30.46989003
124NEK10.46950691
125GRK50.46453079
126ATM0.45899697
127RPS6KA60.45365460
128ZAK0.45216268
129CHEK10.42888077
130PRKCI0.42456591
131MUSK0.41260608
132MAP3K30.41115585
133PBK0.40460329
134MELK0.40340171
135PRKCD0.39978504
136TLK10.39518811
137PNCK0.38720877
138MINK10.38686068
139WNK40.38446138
140PTK2B0.36898409
141CHEK20.34776273
142KSR10.34172896
143FGFR10.31882654
144ERBB40.31555605
145IGF1R0.30911872
146ADRBK10.30328484
147AKT30.29010134
148ABL10.28170702
149DAPK10.28054568
150ROCK10.28021483
151* CSNK2A10.24938537
152PIK3CG0.23936028
153PRKCQ0.22084456
154EGFR0.20936984
155TIE10.19277805
156CSNK1A10.19020509
157GSK3A0.18732405

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.22807073
2Primary immunodeficiency_Homo sapiens_hsa053402.63254607
3Propanoate metabolism_Homo sapiens_hsa006402.52680132
4Mismatch repair_Homo sapiens_hsa034302.43678254
5Leishmaniasis_Homo sapiens_hsa051402.29185136
6Antigen processing and presentation_Homo sapiens_hsa046122.26100671
7Base excision repair_Homo sapiens_hsa034102.21662664
8Proteasome_Homo sapiens_hsa030502.20998845
9Allograft rejection_Homo sapiens_hsa053302.20206488
10Graft-versus-host disease_Homo sapiens_hsa053322.17284067
11Measles_Homo sapiens_hsa051622.01149096
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99959451
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94283821
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.92909123
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87641682
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.86901978
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83174919
18Vitamin B6 metabolism_Homo sapiens_hsa007501.77527749
19Legionellosis_Homo sapiens_hsa051341.76946750
20Cell cycle_Homo sapiens_hsa041101.70903168
21Homologous recombination_Homo sapiens_hsa034401.67726056
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67691177
23Herpes simplex infection_Homo sapiens_hsa051681.66122305
24Spliceosome_Homo sapiens_hsa030401.65954408
25Sulfur metabolism_Homo sapiens_hsa009201.65415629
26Nucleotide excision repair_Homo sapiens_hsa034201.61827893
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58489870
28Fatty acid elongation_Homo sapiens_hsa000621.57041572
29Hematopoietic cell lineage_Homo sapiens_hsa046401.55908551
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53714994
31Caffeine metabolism_Homo sapiens_hsa002321.51394005
32Oxidative phosphorylation_Homo sapiens_hsa001901.50174732
33Non-homologous end-joining_Homo sapiens_hsa034501.48020415
34Viral myocarditis_Homo sapiens_hsa054161.47922172
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47307202
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47154586
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46342196
38Osteoclast differentiation_Homo sapiens_hsa043801.46147499
39B cell receptor signaling pathway_Homo sapiens_hsa046621.44113110
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43498836
41Selenocompound metabolism_Homo sapiens_hsa004501.42007808
42Ribosome_Homo sapiens_hsa030101.40259286
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38905477
44RNA transport_Homo sapiens_hsa030131.38626699
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37000160
46T cell receptor signaling pathway_Homo sapiens_hsa046601.35292472
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33996694
48Malaria_Homo sapiens_hsa051441.31084014
49Parkinsons disease_Homo sapiens_hsa050121.30731375
50Epstein-Barr virus infection_Homo sapiens_hsa051691.27809942
51Shigellosis_Homo sapiens_hsa051311.26601163
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26503023
53Influenza A_Homo sapiens_hsa051641.25110453
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24803292
55p53 signaling pathway_Homo sapiens_hsa041151.24413882
56Toxoplasmosis_Homo sapiens_hsa051451.23913069
57Steroid biosynthesis_Homo sapiens_hsa001001.21900185
58Asthma_Homo sapiens_hsa053101.21584506
59Apoptosis_Homo sapiens_hsa042101.21005999
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.17782671
61Pertussis_Homo sapiens_hsa051331.14183275
62Fanconi anemia pathway_Homo sapiens_hsa034601.11805769
63Tuberculosis_Homo sapiens_hsa051521.11724976
64Hepatitis B_Homo sapiens_hsa051611.11618299
65Pyrimidine metabolism_Homo sapiens_hsa002401.09955755
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.09272448
67Autoimmune thyroid disease_Homo sapiens_hsa053201.08635592
68Nitrogen metabolism_Homo sapiens_hsa009101.08010857
69Type I diabetes mellitus_Homo sapiens_hsa049401.07254433
70Butanoate metabolism_Homo sapiens_hsa006501.07024703
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.06981281
72Viral carcinogenesis_Homo sapiens_hsa052031.06313693
73RNA polymerase_Homo sapiens_hsa030201.05665930
74Pyruvate metabolism_Homo sapiens_hsa006201.05525877
75RNA degradation_Homo sapiens_hsa030181.03359899
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03114269
77Oocyte meiosis_Homo sapiens_hsa041141.00158019
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00039591
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96898625
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96643405
81Salmonella infection_Homo sapiens_hsa051320.96621460
82Glutathione metabolism_Homo sapiens_hsa004800.96297447
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95068725
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94899681
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93969674
86HTLV-I infection_Homo sapiens_hsa051660.92874911
87Phototransduction_Homo sapiens_hsa047440.92727276
88One carbon pool by folate_Homo sapiens_hsa006700.92357734
89Other glycan degradation_Homo sapiens_hsa005110.92126263
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90805056
91TNF signaling pathway_Homo sapiens_hsa046680.90520369
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87517676
93Basal transcription factors_Homo sapiens_hsa030220.87196411
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83718616
95Staphylococcus aureus infection_Homo sapiens_hsa051500.81100251
96Peroxisome_Homo sapiens_hsa041460.80398783
97Chemokine signaling pathway_Homo sapiens_hsa040620.80159315
98Tryptophan metabolism_Homo sapiens_hsa003800.79774425
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78538346
100Systemic lupus erythematosus_Homo sapiens_hsa053220.77318343
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76381826
102Protein export_Homo sapiens_hsa030600.76253850
103Phagosome_Homo sapiens_hsa041450.75447496
104Chronic myeloid leukemia_Homo sapiens_hsa052200.75143091
105Pancreatic cancer_Homo sapiens_hsa052120.74717271
106Small cell lung cancer_Homo sapiens_hsa052220.74555601
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74113682
108Acute myeloid leukemia_Homo sapiens_hsa052210.73812468
109Pentose phosphate pathway_Homo sapiens_hsa000300.72175785
110Rheumatoid arthritis_Homo sapiens_hsa053230.70436165
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69784053
112mRNA surveillance pathway_Homo sapiens_hsa030150.68576474
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.67179659
114Ether lipid metabolism_Homo sapiens_hsa005650.66442141
115N-Glycan biosynthesis_Homo sapiens_hsa005100.66222658
116Huntingtons disease_Homo sapiens_hsa050160.65824564
117Platelet activation_Homo sapiens_hsa046110.65363904
118Lysosome_Homo sapiens_hsa041420.62642150
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62415526
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61889336
121Fatty acid metabolism_Homo sapiens_hsa012120.60304718
122Alzheimers disease_Homo sapiens_hsa050100.59137617
123Hepatitis C_Homo sapiens_hsa051600.58257976
124Collecting duct acid secretion_Homo sapiens_hsa049660.56479421
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.56477516
126Fatty acid degradation_Homo sapiens_hsa000710.55740129
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54819646
128Metabolic pathways_Homo sapiens_hsa011000.54647961
129Colorectal cancer_Homo sapiens_hsa052100.53841486
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53461208
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52165085
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.51995991
133beta-Alanine metabolism_Homo sapiens_hsa004100.51633170
134Thyroid cancer_Homo sapiens_hsa052160.47879549
135HIF-1 signaling pathway_Homo sapiens_hsa040660.46558704
136MicroRNAs in cancer_Homo sapiens_hsa052060.46167305
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46002014
138Linoleic acid metabolism_Homo sapiens_hsa005910.45991564
139Purine metabolism_Homo sapiens_hsa002300.45649483
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45554970
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44445266
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44185812
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44019064
144Sphingolipid metabolism_Homo sapiens_hsa006000.43301354
145Chemical carcinogenesis_Homo sapiens_hsa052040.41723796
146TGF-beta signaling pathway_Homo sapiens_hsa043500.40170967
147Folate biosynthesis_Homo sapiens_hsa007900.40156830
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39297970
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39235200
150Retinol metabolism_Homo sapiens_hsa008300.37455870
151African trypanosomiasis_Homo sapiens_hsa051430.36816746
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36780854
153Carbon metabolism_Homo sapiens_hsa012000.36683782
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.35298259
155Non-small cell lung cancer_Homo sapiens_hsa052230.32836728
156Renin-angiotensin system_Homo sapiens_hsa046140.31362817
157Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30602384
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29948114

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