CAPZA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter secretion (GO:0046929)8.11464847
2positive regulation of amino acid transport (GO:0051957)7.67848335
3negative regulation of amino acid transport (GO:0051956)6.98221271
4phospholipid scrambling (GO:0017121)6.97082695
5positive regulation of catecholamine secretion (GO:0033605)6.75853940
6cullin deneddylation (GO:0010388)6.73237976
7negative regulation of neurotransmitter transport (GO:0051589)6.61061397
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.36220685
9protein deneddylation (GO:0000338)6.08405019
10regulation of glutamate secretion (GO:0014048)6.08197818
11serotonin receptor signaling pathway (GO:0007210)6.01800985
12neutrophil activation involved in immune response (GO:0002283)5.79076494
13proteasome assembly (GO:0043248)5.73521903
14ribosome assembly (GO:0042255)5.43281905
15branched-chain amino acid catabolic process (GO:0009083)5.20897003
16protein neddylation (GO:0045116)4.99939729
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64212087
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64212087
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.64212087
20modulation by symbiont of host immune response (GO:0052553)4.64212087
21positive regulation by symbiont of host defense response (GO:0052509)4.64212087
22modulation by symbiont of host defense response (GO:0052031)4.64212087
23respiratory burst (GO:0045730)4.46548878
24regulation of B cell receptor signaling pathway (GO:0050855)4.32021522
25positive regulation of interferon-alpha production (GO:0032727)4.29820415
26response to peptidoglycan (GO:0032494)4.29104667
27regulation of interferon-beta biosynthetic process (GO:0045357)4.19916235
28branched-chain amino acid metabolic process (GO:0009081)4.07523559
29intestinal epithelial cell development (GO:0060576)4.05953361
30regulation of interferon-alpha production (GO:0032647)4.05597908
31pharyngeal system development (GO:0060037)4.04846838
32immunoglobulin mediated immune response (GO:0016064)4.00863987
33microglial cell activation (GO:0001774)3.97245114
34macrophage activation involved in immune response (GO:0002281)3.96087041
35regulation of amino acid transport (GO:0051955)3.95552949
36negative regulation of interleukin-17 production (GO:0032700)3.92982013
37myeloid cell activation involved in immune response (GO:0002275)3.83531965
38neutrophil activation (GO:0042119)3.75331216
39granulocyte activation (GO:0036230)3.73276926
40phagosome maturation (GO:0090382)3.71456508
41regulation of dopamine secretion (GO:0014059)3.65447139
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.56935010
43DNA replication checkpoint (GO:0000076)3.56263997
44mast cell activation (GO:0045576)3.47565841
45positive regulation of antigen processing and presentation (GO:0002579)3.46666561
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44592955
47production of molecular mediator involved in inflammatory response (GO:0002532)3.39295237
48platelet dense granule organization (GO:0060155)3.39276055
49superoxide anion generation (GO:0042554)3.38855008
50negative regulation of amine transport (GO:0051953)3.38713749
51negative regulation of heart rate (GO:0010459)3.38519372
52positive regulation of monocyte chemotaxis (GO:0090026)3.38357602
53muscle cell fate commitment (GO:0042693)3.36102980
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.35394227
55macrophage activation (GO:0042116)3.32713027
56defense response to protozoan (GO:0042832)3.29389435
57N-glycan processing (GO:0006491)3.28709745
58leukocyte degranulation (GO:0043299)3.27845379
59negative regulation of mast cell activation (GO:0033004)3.27181883
60interferon-gamma-mediated signaling pathway (GO:0060333)3.26535623
61response to host immune response (GO:0052572)3.26279847
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26279847
63protein K11-linked ubiquitination (GO:0070979)3.24920944
64cellular response to interferon-beta (GO:0035458)3.19922560
65regulation of mast cell activation (GO:0033003)3.19027212
66regulation of membrane lipid distribution (GO:0097035)3.13641743
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12808048
68B cell mediated immunity (GO:0019724)3.12511632
69early endosome to late endosome transport (GO:0045022)3.11864900
70positive regulation of amine transport (GO:0051954)3.10133660
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.09171636
72neural tube formation (GO:0001841)3.09073729
73positive regulation of chemokine biosynthetic process (GO:0045080)3.08691404
74leukocyte aggregation (GO:0070486)3.07752366
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05688518
76cellular response to zinc ion (GO:0071294)3.05450865
77hydrogen peroxide biosynthetic process (GO:0050665)3.04685561
78reactive oxygen species biosynthetic process (GO:1903409)3.03823062
79myeloid leukocyte activation (GO:0002274)3.03193451
80myeloid dendritic cell activation (GO:0001773)3.02210565
81regulation of antigen processing and presentation (GO:0002577)3.01196874
82leukocyte mediated cytotoxicity (GO:0001909)2.99923740
83regulation of mast cell degranulation (GO:0043304)2.99824028
84positive regulation of organic acid transport (GO:0032892)2.98128607
85positive regulation of interferon-beta production (GO:0032728)2.96400892
86neutrophil mediated immunity (GO:0002446)2.95038445
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94861263
88negative regulation of activin receptor signaling pathway (GO:0032926)2.93074459
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92903179
90cellular response to type I interferon (GO:0071357)2.92564913
91type I interferon signaling pathway (GO:0060337)2.92564913
92response to interferon-beta (GO:0035456)2.91975977
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91634081
94response to protozoan (GO:0001562)2.90571214
95regulation of mast cell activation involved in immune response (GO:0033006)2.89871115
96regulation of chemokine biosynthetic process (GO:0045073)2.87441141
97positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.87395283
98actin nucleation (GO:0045010)2.86918070
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86271036
100response to host (GO:0075136)2.86271036
101response to host defenses (GO:0052200)2.86271036
102response to type I interferon (GO:0034340)2.85917077
103positive regulation of cellular amide metabolic process (GO:0034250)2.85735869
104regulation of T-helper 1 cell differentiation (GO:0045625)2.84485774
105nucleotide transmembrane transport (GO:1901679)2.84437141
106antigen processing and presentation of endogenous antigen (GO:0019883)2.83157064
107positive regulation of mast cell activation (GO:0033005)2.82762951
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82308208
109histamine secretion (GO:0001821)2.82290225
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81559614
111regulation of Golgi to plasma membrane protein transport (GO:0042996)2.81223093
112adenosine metabolic process (GO:0046085)2.80692614
113signal peptide processing (GO:0006465)2.80022787
114positive regulation of interleukin-12 production (GO:0032735)2.79152486
115myeloid dendritic cell differentiation (GO:0043011)2.77809855
116regulation of monocyte chemotaxis (GO:0090025)2.76462280
117regulation of interleukin-17 production (GO:0032660)2.75428773
118phagocytosis, engulfment (GO:0006911)2.75104804
119B cell receptor signaling pathway (GO:0050853)2.73076613
120natural killer cell mediated immunity (GO:0002228)2.70771696
121natural killer cell mediated cytotoxicity (GO:0042267)2.70771696
122cellular response to exogenous dsRNA (GO:0071360)2.70335715
123positive regulation of lymphocyte migration (GO:2000403)2.70287220
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69950545
125eosinophil chemotaxis (GO:0048245)2.68345099
126regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.67591207
127negative regulation of protein tyrosine kinase activity (GO:0061099)2.67227885
128positive regulation of mast cell activation involved in immune response (GO:0033008)2.66681665
129positive regulation of mast cell degranulation (GO:0043306)2.66681665
130positive regulation of macrophage differentiation (GO:0045651)2.66093785
131germinal center formation (GO:0002467)2.66043840
132regulation of fever generation (GO:0031620)2.65411326
133regulation of integrin-mediated signaling pathway (GO:2001044)2.65280306
134DNA double-strand break processing (GO:0000729)2.65151433
135positive regulation of protein autophosphorylation (GO:0031954)2.64098992
136xenobiotic catabolic process (GO:0042178)2.63791448
137mast cell degranulation (GO:0043303)2.62093424
138mast cell activation involved in immune response (GO:0002279)2.62093424
139negative regulation of organic acid transport (GO:0032891)2.61559461
140positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61330100
141sequestering of actin monomers (GO:0042989)2.60976969
142myeloid leukocyte mediated immunity (GO:0002444)2.60338545
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60212182
144female gonad development (GO:0008585)2.59945341
145positive regulation of heat generation (GO:0031652)2.59383411
146positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59275750
147intracellular pH reduction (GO:0051452)2.58766021
148antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.58698832
149mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58579335
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.58579335
151NADH dehydrogenase complex assembly (GO:0010257)2.58579335
152lymphocyte chemotaxis (GO:0048247)2.58161109
153respiratory chain complex IV assembly (GO:0008535)2.58110717
154pathway-restricted SMAD protein phosphorylation (GO:0060389)2.56467334
155water-soluble vitamin biosynthetic process (GO:0042364)2.52876342
156amino acid salvage (GO:0043102)2.50595740
157L-methionine salvage (GO:0071267)2.50595740
158L-methionine biosynthetic process (GO:0071265)2.50595740
159protein complex biogenesis (GO:0070271)2.49373194
160negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.47848278
161negative regulation of membrane potential (GO:0045837)2.47265538
162protein prenylation (GO:0018342)2.47170132
163prenylation (GO:0097354)2.47170132
164regulation of acyl-CoA biosynthetic process (GO:0050812)2.46076906
165ribonucleoprotein complex disassembly (GO:0032988)2.45499034
166regulation of cellular amino acid metabolic process (GO:0006521)2.45256702
167response to nitrosative stress (GO:0051409)2.44501774
168mitotic G2 DNA damage checkpoint (GO:0007095)2.42281644
169chaperone-mediated protein transport (GO:0072321)2.41169067
170C-terminal protein lipidation (GO:0006501)2.40873323
171mannose metabolic process (GO:0006013)2.40742383
172cellular glucuronidation (GO:0052695)2.40007889
173negative regulation of thymocyte apoptotic process (GO:0070244)2.39997360
174pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.39505319
175uronic acid metabolic process (GO:0006063)2.38897663
176glucuronate metabolic process (GO:0019585)2.38897663
177regulation of relaxation of muscle (GO:1901077)2.38518873
178organelle disassembly (GO:1903008)2.35293472
179somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.34472453
180somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.34472453
181isotype switching (GO:0045190)2.34472453
182kynurenine metabolic process (GO:0070189)2.34132526
183exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32510609
184negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.32276031
185negative regulation of ligase activity (GO:0051352)2.32276031
186establishment of protein localization to mitochondrial membrane (GO:0090151)2.31928976
187regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.31671167
188mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.30476462
189nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.28024843
190regulation of cilium movement (GO:0003352)2.27379144
191mitochondrial respiratory chain complex assembly (GO:0033108)2.26528856
192preassembly of GPI anchor in ER membrane (GO:0016254)2.25494443
193regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.23474687
194mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.22045876
195C-terminal protein amino acid modification (GO:0018410)2.21632006
196anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.17656211
197lactate metabolic process (GO:0006089)2.17446441
198positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.17150225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse7.01758792
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.62101374
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.71656762
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.47340965
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.94218179
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81106366
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56406996
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28308049
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05705882
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04736709
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04709255
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.85777587
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80005022
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60542640
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60124143
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55994748
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.52991549
18EWS_26573619_Chip-Seq_HEK293_Human2.47528918
19* SPI1_23547873_ChIP-Seq_NB4_Human2.29741510
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.99652401
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97923101
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97255323
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96654252
24ZNF274_21170338_ChIP-Seq_K562_Hela1.96009948
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88090563
26ELK1_19687146_ChIP-ChIP_HELA_Human1.87329092
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84289311
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.82817821
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81271198
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81082987
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77816918
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73663208
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73604823
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73348293
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70879869
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70222935
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68891489
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66295456
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64708091
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63347701
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62670402
42MYB_26560356_Chip-Seq_TH2_Human1.60789870
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.59840340
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.59453188
45* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59192313
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58596072
47PU_27001747_Chip-Seq_BMDM_Mouse1.58113605
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57197756
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56419018
50HTT_18923047_ChIP-ChIP_STHdh_Human1.54799711
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.53650417
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53113893
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51995958
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.51157358
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.49968687
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47901847
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46535513
58SMAD4_21799915_ChIP-Seq_A2780_Human1.45423550
59GATA1_22025678_ChIP-Seq_K562_Human1.44848724
60* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42494132
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.38515055
62GATA3_26560356_Chip-Seq_TH2_Human1.38464389
63* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38137588
64RUNX_20019798_ChIP-Seq_JUKART_Human1.37693652
65* SOX2_19829295_ChIP-Seq_ESCs_Human1.36875170
66* NANOG_19829295_ChIP-Seq_ESCs_Human1.36875170
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36000996
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35224174
69SPI1_23127762_ChIP-Seq_K562_Human1.34275218
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33581898
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33406350
72* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32999758
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32341770
74* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32209313
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31874589
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31050689
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.30845119
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30570501
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30092413
80* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30076378
81P300_18555785_Chip-Seq_ESCs_Mouse1.29270927
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28816211
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27646494
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.25660785
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24612430
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.23867272
87* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23478434
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.23399624
89BCAT_22108803_ChIP-Seq_LS180_Human1.22390096
90VDR_24787735_ChIP-Seq_THP-1_Human1.22310277
91CDX2_22108803_ChIP-Seq_LS180_Human1.22165018
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21591748
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21591748
94* TAL1_26923725_Chip-Seq_HPCs_Mouse1.21423741
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21285833
96* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20737145
97* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20208964
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.19627226
99TAF15_26573619_Chip-Seq_HEK293_Human1.18711308
100CJUN_26792858_Chip-Seq_BT549_Human1.16556910
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16427085
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.16218293
103TCF4_22108803_ChIP-Seq_LS180_Human1.15860776
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15804594
105CBP_20019798_ChIP-Seq_JUKART_Human1.15435804
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15435804
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14443593
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14391134
109* AR_25329375_ChIP-Seq_VCAP_Human1.13615442
110GBX2_23144817_ChIP-Seq_PC3_Human1.12691380
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11326453
112* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11106033
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10490803
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.10419744
115* TP53_22573176_ChIP-Seq_HFKS_Human1.10404511
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.09891624
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09001455
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.07979173
119* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07805102
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.07195343
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06982929
122CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06537515
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06480256
124BRD4_25478319_ChIP-Seq_HGPS_Human1.06276487
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05971425
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05756573
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05643563
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05369084
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05299930
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05206137
131FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04625795
132FOXA1_25329375_ChIP-Seq_VCAP_Human1.04625795
133STAT3_23295773_ChIP-Seq_U87_Human1.04551157
134* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04498792
135P300_19829295_ChIP-Seq_ESCs_Human1.03924393
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03562713
137GATA3_27048872_Chip-Seq_THYMUS_Human1.03063340
138VDR_24763502_ChIP-Seq_THP-1_Human1.02412450
139MYB_26560356_Chip-Seq_TH1_Human1.01712207
140* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99422511
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99305007
142FUS_26573619_Chip-Seq_HEK293_Human0.98194860
143* VDR_23849224_ChIP-Seq_CD4+_Human0.97160559
144ER_23166858_ChIP-Seq_MCF-7_Human0.95943501
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94244490
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.93524505
147PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92728093
148SALL4_22934838_ChIP-ChIP_CD34+_Human0.92677415
149* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87890810
150SCL_19346495_ChIP-Seq_HPC-7_Human0.87004689
151HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86122611
152VDR_22108803_ChIP-Seq_LS180_Human0.85933394
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83362309
154FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83227574
155* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82779080
156P53_22387025_ChIP-Seq_ESCs_Mouse0.81401499
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.81145906
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80471523
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.80320015
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80068794
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79248650
162* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79048431
163TFEB_21752829_ChIP-Seq_HELA_Human0.78445498
164MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78434918
165* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78188228
166CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78041516
167IGF1R_20145208_ChIP-Seq_DFB_Human0.76544169
168PU1_27457419_Chip-Seq_LIVER_Mouse0.75465644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.99478763
2MP0008961_abnormal_basal_metabolism3.96922677
3MP0009785_altered_susceptibility_to3.88138830
4MP0002148_abnormal_hypersensitivity_rea3.75935668
5MP0003656_abnormal_erythrocyte_physiolo3.60779285
6MP0004215_abnormal_myocardial_fiber3.44841776
7MP0002822_catalepsy3.35780472
8MP0003436_decreased_susceptibility_to3.24724178
9MP0002419_abnormal_innate_immunity3.06488835
10MP0005000_abnormal_immune_tolerance2.98068645
11MP0005671_abnormal_response_to2.86944740
12MP0003806_abnormal_nucleotide_metabolis2.86573061
13MP0003724_increased_susceptibility_to2.79091114
14MP0005025_abnormal_response_to2.73562311
15MP0006082_CNS_inflammation2.68664125
16MP0002102_abnormal_ear_morphology2.67759284
17MP0004510_myositis2.65556255
18MP0002452_abnormal_antigen_presenting2.54117076
19MP0005058_abnormal_lysosome_morphology2.50227908
20MP0003303_peritoneal_inflammation2.50090483
21MP0004484_altered_response_of2.39781360
22MP0001790_abnormal_immune_system2.38928667
23MP0005387_immune_system_phenotype2.38928667
24MP0002723_abnormal_immune_serum2.38882148
25MP0002234_abnormal_pharynx_morphology2.38208508
26MP0002837_dystrophic_cardiac_calcinosis2.32571330
27MP0003195_calcinosis2.32554062
28MP0001819_abnormal_immune_cell2.28117640
29MP0001800_abnormal_humoral_immune2.27231417
30MP0002420_abnormal_adaptive_immunity2.26127075
31MP0003880_abnormal_central_pattern2.12707374
32MP0000685_abnormal_immune_system2.07120622
33MP0005464_abnormal_platelet_physiology1.98666862
34MP0004084_abnormal_cardiac_muscle1.98114370
35MP0003172_abnormal_lysosome_physiology1.93590962
36MP0006036_abnormal_mitochondrial_physio1.92760053
37MP0008058_abnormal_DNA_repair1.88388552
38MP0001533_abnormal_skeleton_physiology1.86868439
39MP0001853_heart_inflammation1.85343614
40MP0002006_tumorigenesis1.84039551
41MP0000343_altered_response_to1.80503651
42MP0001529_abnormal_vocalization1.72224184
43MP0003075_altered_response_to1.69121038
44MP0001845_abnormal_inflammatory_respons1.61596550
45MP0003183_abnormal_peptide_metabolism1.59906658
46MP0002090_abnormal_vision1.58457401
47MP0000716_abnormal_immune_system1.55209926
48MP0002405_respiratory_system_inflammati1.52873108
49MP0000749_muscle_degeneration1.49224743
50MP0008775_abnormal_heart_ventricle1.49103738
51MP0002398_abnormal_bone_marrow1.48584278
52MP0009764_decreased_sensitivity_to1.48430944
53MP0005310_abnormal_salivary_gland1.44581362
54MP0006072_abnormal_retinal_apoptosis1.44290652
55MP0003786_premature_aging1.43523453
56MP0003191_abnormal_cellular_cholesterol1.41887634
57MP0002736_abnormal_nociception_after1.39386375
58MP0005084_abnormal_gallbladder_morpholo1.39240971
59MP0002166_altered_tumor_susceptibility1.37502855
60MP0004859_abnormal_synaptic_plasticity1.35800822
61MP0008469_abnormal_protein_level1.35441442
62MP0010155_abnormal_intestine_physiology1.33304101
63MP0005253_abnormal_eye_physiology1.31550081
64MP0004145_abnormal_muscle_electrophysio1.30503689
65MP0005166_decreased_susceptibility_to1.29747770
66MP0003448_altered_tumor_morphology1.29684647
67MP0000015_abnormal_ear_pigmentation1.29619261
68MP0003868_abnormal_feces_composition1.27886278
69MP0008877_abnormal_DNA_methylation1.27782733
70MP0004036_abnormal_muscle_relaxation1.26622268
71MP0003011_delayed_dark_adaptation1.26434567
72MP0000689_abnormal_spleen_morphology1.25240269
73MP0009333_abnormal_splenocyte_physiolog1.24836687
74MP0000858_altered_metastatic_potential1.24083017
75MP0002429_abnormal_blood_cell1.23298809
76MP0010094_abnormal_chromosome_stability1.21115403
77MP0003950_abnormal_plasma_membrane1.20559271
78MP0000604_amyloidosis1.20148887
79MP0004947_skin_inflammation1.15219421
80MP0005367_renal/urinary_system_phenotyp1.14140657
81MP0000516_abnormal_urinary_system1.14140657
82MP0001968_abnormal_touch/_nociception1.12218916
83MP0001545_abnormal_hematopoietic_system1.11935201
84MP0005397_hematopoietic_system_phenotyp1.11935201
85MP0002722_abnormal_immune_system1.11407484
86MP0003828_pulmonary_edema1.11097469
87MP0005174_abnormal_tail_pigmentation1.10203511
88MP0005171_absent_coat_pigmentation1.10167746
89MP0002998_abnormal_bone_remodeling1.09849950
90MP0002972_abnormal_cardiac_muscle1.08914691
91MP0008260_abnormal_autophagy1.08646651
92MP0005085_abnormal_gallbladder_physiolo1.07661846
93MP0005620_abnormal_muscle_contractility1.07569766
94MP0004957_abnormal_blastocyst_morpholog1.06774293
95MP0005164_abnormal_response_to1.06132022
96MP0010386_abnormal_urinary_bladder1.05946604
97MP0002277_abnormal_respiratory_mucosa1.04380497
98MP0008872_abnormal_physiological_respon1.04123189
99MP0006035_abnormal_mitochondrial_morpho1.03647810
100MP0008875_abnormal_xenobiotic_pharmacok1.02902130
101MP0001984_abnormal_olfaction1.02723729
102MP0003690_abnormal_glial_cell1.02371341
103MP0005332_abnormal_amino_acid1.01940156
104MP0004142_abnormal_muscle_tone1.01569761
105MP0002396_abnormal_hematopoietic_system1.01471803
106MP0005365_abnormal_bile_salt1.00160372
107MP0005266_abnormal_metabolism0.99803763
108MP0000013_abnormal_adipose_tissue0.99290814
109MP0000230_abnormal_systemic_arterial0.98620567
110MP0001764_abnormal_homeostasis0.98012332
111MP0005167_abnormal_blood-brain_barrier0.97683419
112MP0004808_abnormal_hematopoietic_stem0.96472439
113MP0005551_abnormal_eye_electrophysiolog0.95073611
114MP0004782_abnormal_surfactant_physiolog0.94802417
115MP0000465_gastrointestinal_hemorrhage0.93498891
116MP0009697_abnormal_copulation0.92815528
117MP0009765_abnormal_xenobiotic_induced0.92500563
118MP0003252_abnormal_bile_duct0.92415981
119MP0001501_abnormal_sleep_pattern0.92299497
120MP0008932_abnormal_embryonic_tissue0.86049617
121MP0002064_seizures0.85911145
122MP0003763_abnormal_thymus_physiology0.85827615
123MP0000372_irregular_coat_pigmentation0.85709973
124MP0003718_maternal_effect0.84361068
125MP0009745_abnormal_behavioral_response0.84300912
126MP0000613_abnormal_salivary_gland0.83609626
127MP0005376_homeostasis/metabolism_phenot0.82162824
128MP0005385_cardiovascular_system_phenoty0.82060012
129MP0001544_abnormal_cardiovascular_syste0.82060012
130MP0009046_muscle_twitch0.81172247
131MP0003137_abnormal_impulse_conducting0.81071613
132MP0003186_abnormal_redox_activity0.80317565
133MP0008007_abnormal_cellular_replicative0.79561922
134MP0004883_abnormal_blood_vessel0.79485588
135MP0002735_abnormal_chemical_nociception0.79357631
136MP0004085_abnormal_heartbeat0.78960968
137MP0001188_hyperpigmentation0.78620524
138MP0005595_abnormal_vascular_smooth0.78536726
139MP0003646_muscle_fatigue0.78255034
140MP0006054_spinal_hemorrhage0.77053828
141MP0008057_abnormal_DNA_replication0.75096760
142MP0005390_skeleton_phenotype0.73636994
143MP0001542_abnormal_bone_strength0.72775838
144MP0002332_abnormal_exercise_endurance0.71745304
145MP0001664_abnormal_digestion0.70072692
146MP0005330_cardiomyopathy0.69183372
147MP0003635_abnormal_synaptic_transmissio0.68858178
148MP0008004_abnormal_stomach_pH0.68722354
149MP0002876_abnormal_thyroid_physiology0.68593197
150MP0003633_abnormal_nervous_system0.68389351
151MP0004147_increased_porphyrin_level0.67930695
152MP0000569_abnormal_digit_pigmentation0.67561139
153MP0002063_abnormal_learning/memory/cond0.67150547
154MP0003221_abnormal_cardiomyocyte_apopto0.67108268
155MP0001986_abnormal_taste_sensitivity0.66502226
156MP0001666_abnormal_nutrient_absorption0.66102429
157MP0003866_abnormal_defecation0.65594161
158MP0005636_abnormal_mineral_homeostasis0.65475572
159MP0008995_early_reproductive_senescence0.65372151
160MP0001191_abnormal_skin_condition0.65241276
161MP0001756_abnormal_urination0.64246271
162MP0000249_abnormal_blood_vessel0.63477316
163MP0005165_increased_susceptibility_to0.63318387
164MP0010307_abnormal_tumor_latency0.61836014
165MP0002933_joint_inflammation0.61554779
166MP0000681_abnormal_thyroid_gland0.61430501
167MP0001663_abnormal_digestive_system0.60197032
168MP0002095_abnormal_skin_pigmentation0.60038520

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.40919544
2Recurrent bacterial skin infections (HP:0005406)6.71388686
3Eczematoid dermatitis (HP:0000976)5.93850890
4Recurrent gram-negative bacterial infections (HP:0005420)4.75999722
5Mediastinal lymphadenopathy (HP:0100721)4.52939464
6Abnormality of macrophages (HP:0004311)4.33587001
7Elevated erythrocyte sedimentation rate (HP:0003565)4.10285942
8Myositis (HP:0100614)4.10085428
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.03837076
10Increased hepatocellular lipid droplets (HP:0006565)4.02478362
11Cerebral edema (HP:0002181)3.93360960
12Increased cerebral lipofuscin (HP:0011813)3.88378339
13Agnosia (HP:0010524)3.85768517
14Methylmalonic acidemia (HP:0002912)3.82819219
15Obstructive lung disease (HP:0006536)3.76044388
16Chronic obstructive pulmonary disease (HP:0006510)3.76044388
17Menorrhagia (HP:0000132)3.74099416
18Recurrent skin infections (HP:0001581)3.67169984
19Vacuolated lymphocytes (HP:0001922)3.66259969
20Orchitis (HP:0100796)3.56916966
21Retrobulbar optic neuritis (HP:0100654)3.56261255
22Optic neuritis (HP:0100653)3.56261255
23Lipid accumulation in hepatocytes (HP:0006561)3.54634472
24Renal Fanconi syndrome (HP:0001994)3.51257713
25Abnormality of the intrinsic pathway (HP:0010989)3.45418340
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.41099392
27Short 1st metacarpal (HP:0010034)3.41099392
28Stomatitis (HP:0010280)3.33158117
29Gingivitis (HP:0000230)3.29452478
30Systemic lupus erythematosus (HP:0002725)3.23359607
31Increased IgM level (HP:0003496)3.17293825
32Prostate neoplasm (HP:0100787)3.07380927
33Disinhibition (HP:0000734)3.03309693
34Abnormality of the 1st metacarpal (HP:0010009)2.99530903
35Progressive macrocephaly (HP:0004481)2.97714640
36Recurrent fungal infections (HP:0002841)2.97297655
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95958994
38Abnormality of methionine metabolism (HP:0010901)2.91310687
39Ketosis (HP:0001946)2.90903663
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.90801076
41Basal ganglia calcification (HP:0002135)2.87638879
42Exercise-induced muscle cramps (HP:0003710)2.87517848
43Autoimmune thrombocytopenia (HP:0001973)2.85569549
44Chronic otitis media (HP:0000389)2.84550512
45Acute encephalopathy (HP:0006846)2.84073686
46Recurrent viral infections (HP:0004429)2.83644416
47Stenosis of the external auditory canal (HP:0000402)2.80580282
48Abnormality of the common coagulation pathway (HP:0010990)2.79856665
49Increased CSF lactate (HP:0002490)2.79180659
50Abnormality of the renal collecting system (HP:0004742)2.77563917
51Abnormality of glycolipid metabolism (HP:0010969)2.76816562
52Abnormality of liposaccharide metabolism (HP:0010968)2.76816562
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.76816562
54Abnormality of alanine metabolism (HP:0010916)2.76178569
55Hyperalaninemia (HP:0003348)2.76178569
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76178569
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74313587
58Methylmalonic aciduria (HP:0012120)2.74231356
59Dyschromatopsia (HP:0007641)2.71206682
60Recurrent pneumonia (HP:0006532)2.69425391
61Abnormality of vitamin B metabolism (HP:0004340)2.68855162
62Abnormality of the prostate (HP:0008775)2.68815968
63Cellulitis (HP:0100658)2.68780798
64Vasculitis (HP:0002633)2.68203905
65Meningitis (HP:0001287)2.65719826
66Hepatic necrosis (HP:0002605)2.65607009
67Medial flaring of the eyebrow (HP:0010747)2.64201391
68Lethargy (HP:0001254)2.61199160
69Abnormality of the vitamin B12 metabolism (HP:0004341)2.60567745
70Hepatocellular necrosis (HP:0001404)2.57930419
71Increased intramyocellular lipid droplets (HP:0012240)2.57820010
72Abnormal mitochondria in muscle tissue (HP:0008316)2.55754153
73Palpitations (HP:0001962)2.55630637
74Hepatosplenomegaly (HP:0001433)2.54668470
75Focal motor seizures (HP:0011153)2.54352071
76Keratoconjunctivitis sicca (HP:0001097)2.50772958
77Pulmonary infiltrates (HP:0002113)2.50727771
78Poor head control (HP:0002421)2.49940348
79Lactic acidosis (HP:0003128)2.49513199
80Abnormality of urine glucose concentration (HP:0011016)2.48595948
81Glycosuria (HP:0003076)2.48595948
82Petechiae (HP:0000967)2.45464241
83Osteomyelitis (HP:0002754)2.44619139
84Optic disc pallor (HP:0000543)2.44370369
85Abnormality of serum amino acid levels (HP:0003112)2.43453333
86Inappropriate behavior (HP:0000719)2.42726735
87Hypergammaglobulinemia (HP:0010702)2.42303194
88Respiratory failure (HP:0002878)2.36855597
89Constricted visual fields (HP:0001133)2.36124511
90Esophageal neoplasm (HP:0100751)2.34346750
91Neoplasm of head and neck (HP:0012288)2.34346750
92Periodontitis (HP:0000704)2.33763317
93Axonal loss (HP:0003447)2.32449400
94Abnormality of renal resorption (HP:0011038)2.31883078
95IgM deficiency (HP:0002850)2.31017902
96Abnormal rod and cone electroretinograms (HP:0008323)2.31008973
97Keratoconjunctivitis (HP:0001096)2.28125852
98Abolished electroretinogram (ERG) (HP:0000550)2.27436643
99Dysostosis multiplex (HP:0000943)2.25590261
100Type I transferrin isoform profile (HP:0003642)2.24621275
101Hypoglycemic coma (HP:0001325)2.24522190
102Degeneration of anterior horn cells (HP:0002398)2.24064625
103Abnormality of the anterior horn cell (HP:0006802)2.24064625
104Urticaria (HP:0001025)2.19982651
105Nemaline bodies (HP:0003798)2.19950581
106Thick nail (HP:0001805)2.17914800
107Pustule (HP:0200039)2.16894785
108Large for gestational age (HP:0001520)2.16189059
109Recurrent lower respiratory tract infections (HP:0002783)2.13987420
110Fused cervical vertebrae (HP:0002949)2.13932212
111Increased mean platelet volume (HP:0011877)2.10706568
112Eosinophilia (HP:0001880)2.08852503
113Pancreatic islet-cell hyperplasia (HP:0004510)2.08163020
114Papillary thyroid carcinoma (HP:0002895)2.06260505
115Neuroendocrine neoplasm (HP:0100634)2.06143193
116Leukocytosis (HP:0001974)2.05313985
117Chronic mucocutaneous candidiasis (HP:0002728)2.05183658
118Recurrent cutaneous fungal infections (HP:0011370)2.05183658
119Heterochromia iridis (HP:0001100)2.03663649
120Upper motor neuron abnormality (HP:0002127)2.03467558
121Chorioretinal atrophy (HP:0000533)2.03200383
122Muscle hypertrophy of the lower extremities (HP:0008968)2.02172385
123Pancreatitis (HP:0001733)2.01148428
124Arterial thrombosis (HP:0004420)2.00072713
125Metaphyseal dysplasia (HP:0100255)1.99888767
126Mutism (HP:0002300)1.99495182
127IgG deficiency (HP:0004315)1.97070378
128Muscle fiber inclusion bodies (HP:0100299)1.96194986
129Interstitial pulmonary disease (HP:0006530)1.96169191
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.95977630
131Thrombocytosis (HP:0001894)1.95959231
132Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95578955
133Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95578955
134Glomerulonephritis (HP:0000099)1.95264663
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95234349
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.94255171
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93497712
138J-shaped sella turcica (HP:0002680)1.93173854
139Abnormal hair whorl (HP:0010721)1.93052687
140Hypoproteinemia (HP:0003075)1.91855523
141Increased serum lactate (HP:0002151)1.90332880
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88678208
143Vertebral compression fractures (HP:0002953)1.88535086
144Attenuation of retinal blood vessels (HP:0007843)1.88268986
145Congenital, generalized hypertrichosis (HP:0004540)1.87506550
146Short hallux (HP:0010109)1.87373216
147Increased muscle lipid content (HP:0009058)1.87223920
148Hemoptysis (HP:0002105)1.85397823
149Thyroiditis (HP:0100646)1.84612285
150Diminished motivation (HP:0000745)1.84591768
151Renal cortical cysts (HP:0000803)1.84256079
152Hyperinsulinemic hypoglycemia (HP:0000825)1.83692721
153Thyroid carcinoma (HP:0002890)1.82938784
154Papilledema (HP:0001085)1.82589218
155Granulocytopenia (HP:0001913)1.81609756
1563-Methylglutaconic aciduria (HP:0003535)1.80071640
157Rimmed vacuoles (HP:0003805)1.79974667
158Mucosal telangiectasiae (HP:0100579)1.79862484
159Epistaxis (HP:0000421)1.79717091
160Mitochondrial inheritance (HP:0001427)1.79591969
161B lymphocytopenia (HP:0010976)1.78988086
162Encephalitis (HP:0002383)1.78782589
163Short phalanx of the thumb (HP:0009660)1.78557300
164Autoimmune hemolytic anemia (HP:0001890)1.77289105
165Abnormality of the basal ganglia (HP:0002134)1.77223001
166Widely spaced teeth (HP:0000687)1.76384126
167Abnormal platelet volume (HP:0011876)1.75911873
168Sepsis (HP:0100806)1.75576206
169Choroideremia (HP:0001139)1.75556205
170Neoplasm of the adrenal gland (HP:0100631)1.75294762
171Acanthocytosis (HP:0001927)1.74736741
172Exertional dyspnea (HP:0002875)1.74427229
173Abnormality of vitamin metabolism (HP:0100508)1.73897776
174Abnormality of eosinophils (HP:0001879)1.73627262
175Abnormal biliary tract morphology (HP:0012440)1.73023461
176Respiratory difficulties (HP:0002880)1.72394471
177Apathy (HP:0000741)1.72158238
178Congenital primary aphakia (HP:0007707)1.72032873
179Pulmonary fibrosis (HP:0002206)1.71531515
180Skin ulcer (HP:0200042)1.70748240
181Aplasia/Hypoplasia of the fovea (HP:0008060)1.69601239
182Hypoplasia of the fovea (HP:0007750)1.69601239
183CNS demyelination (HP:0007305)1.69545355
184Memory impairment (HP:0002354)1.68109668
185Premature loss of primary teeth (HP:0006323)1.67881920
186Abnormality of T cell physiology (HP:0011840)1.67122454
187Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66484650
188Recurrent bronchitis (HP:0002837)1.66478283
189Hypothermia (HP:0002045)1.64597512
190Hypokinesia (HP:0002375)1.64527012
191Xerostomia (HP:0000217)1.64425523
192Palpebral edema (HP:0100540)1.64239779
193Atonic seizures (HP:0010819)1.62889889
194Acute necrotizing encephalopathy (HP:0006965)1.62410078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.99229974
2RIPK44.75800298
3MAP3K123.54511975
4MAP3K143.44702724
5TXK2.57083015
6FRK2.56238365
7BLK2.56006581
8MST42.53360476
9IRAK42.46862466
10TRIM282.31960934
11BMPR22.30533815
12KIT2.23212889
13PBK2.21647252
14CASK2.18967469
15TBK12.12384266
16ARAF2.03793169
17MAP4K11.90321656
18EIF2AK11.88367679
19PIM21.85148403
20PLK21.77922826
21TEC1.77696789
22CAMKK21.73159146
23TYK21.72101312
24SYK1.70196012
25WNK31.63624040
26MAP4K21.62283189
27CCNB11.58843075
28CSF1R1.54324304
29FES1.43143597
30IKBKE1.40837616
31DAPK11.40093253
32OBSCN1.38530555
33ERBB31.38207611
34SIK31.36785729
35IKBKB1.36171770
36GRK71.36006389
37NUAK11.34004563
38JAK31.33772016
39MAP3K131.31009940
40LYN1.23496743
41ZAK1.20727984
42MKNK21.18951710
43IRAK31.09171782
44GRK11.08607982
45MKNK11.07828535
46BTK1.03847413
47RAF11.03593930
48INSRR1.01981820
49YES11.01564240
50CDK191.01232996
51EIF2AK31.00112313
52MYLK0.99104525
53HCK0.98899361
54NEK10.98655291
55ZAP700.98001553
56ADRBK20.96179779
57STK160.93756696
58SRPK10.92887173
59LCK0.92719549
60JAK10.92199520
61PIK3CG0.91518134
62NEK90.91325033
63TSSK60.91315879
64EPHA40.90129722
65BMPR1B0.90070572
66MAP2K70.90058424
67OXSR10.89757223
68CLK10.87465559
69MATK0.85880172
70TRPM70.85526880
71FGR0.84620162
72EIF2AK20.84497890
73ACVR1B0.82768723
74MINK10.79674592
75MAP3K40.79346818
76CSNK1G10.78931862
77BUB10.78879890
78NTRK30.78825519
79STK390.78181094
80FER0.77796124
81STK30.75125801
82CSNK1A1L0.74718181
83TGFBR20.74362363
84MAPK130.74149911
85ITK0.73730929
86NME20.73183195
87TIE10.72421866
88CSNK1G30.71452199
89PRKCD0.71426925
90CSNK1G20.71287306
91BRSK20.69820365
92STK38L0.68046867
93MAP2K30.66105598
94ABL20.65536511
95PDK20.64086802
96PINK10.63679733
97PTK2B0.63318106
98CSK0.62892046
99MOS0.62230185
100ABL10.61655306
101TAOK30.61630210
102CAMKK10.60493938
103TESK10.60249666
104VRK10.60051857
105TGFBR10.58655884
106PRPF4B0.57945985
107PRKCQ0.56550051
108LIMK10.55324833
109NME10.53870417
110PLK40.52829767
111BCR0.51863723
112PHKG10.50812690
113PHKG20.50812690
114PAK30.50556419
115SCYL20.47937619
116FLT30.46987955
117GRK50.45967468
118STK240.44919189
119MST1R0.43745495
120ILK0.43576943
121MAP3K50.41268220
122CHUK0.40564848
123GRK60.40022840
124PRKCE0.39702551
125RPS6KA40.39060542
126PIM10.38361259
127CAMK2A0.37368310
128MARK30.37288496
129PDK10.36422918
130JAK20.35810890
131WEE10.35095491
132NLK0.34329041
133PLK30.33621126
134KSR10.33522125
135TAOK20.33110801
136CDK80.32981081
137TNIK0.32877593
138FYN0.32420676
139ADRBK10.32366797
140EGFR0.32075111
141EPHA30.32048555
142MAP3K90.31902022
143DAPK20.31631767
144IGF1R0.31175547
145CAMK2D0.29371629
146INSR0.28479864
147PRKG10.24990707
148PLK10.24808168
149MUSK0.23880133
150MAP2K60.23793194
151PRKCG0.23494545
152CAMK2G0.22348455
153IRAK10.21841227

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006404.58999103
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.13941039
3Graft-versus-host disease_Homo sapiens_hsa053322.76820564
4Leishmaniasis_Homo sapiens_hsa051402.72162064
5Rheumatoid arthritis_Homo sapiens_hsa053232.51388702
6Sulfur relay system_Homo sapiens_hsa041222.30892944
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29430783
8Legionellosis_Homo sapiens_hsa051342.29423596
9Allograft rejection_Homo sapiens_hsa053302.26510730
10Phagosome_Homo sapiens_hsa041452.18252855
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14840920
12Proteasome_Homo sapiens_hsa030502.11962247
13Pertussis_Homo sapiens_hsa051332.10838788
14Collecting duct acid secretion_Homo sapiens_hsa049662.10259004
15Sulfur metabolism_Homo sapiens_hsa009202.08043805
16Tuberculosis_Homo sapiens_hsa051522.03272731
17Type I diabetes mellitus_Homo sapiens_hsa049402.03236556
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93723505
19Fatty acid elongation_Homo sapiens_hsa000621.87624782
20Osteoclast differentiation_Homo sapiens_hsa043801.85022003
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83795148
22Non-homologous end-joining_Homo sapiens_hsa034501.81472571
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77587576
24Starch and sucrose metabolism_Homo sapiens_hsa005001.75203973
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74791519
26Salmonella infection_Homo sapiens_hsa051321.73450340
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73153103
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.66699091
29Staphylococcus aureus infection_Homo sapiens_hsa051501.66510218
30Malaria_Homo sapiens_hsa051441.66283885
31Measles_Homo sapiens_hsa051621.65937558
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65469021
33Lysosome_Homo sapiens_hsa041421.64560674
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62011021
35African trypanosomiasis_Homo sapiens_hsa051431.60565170
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60166112
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58585743
38Nitrogen metabolism_Homo sapiens_hsa009101.58238349
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54939092
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.54168471
41Shigellosis_Homo sapiens_hsa051311.52958543
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52676700
43Basal transcription factors_Homo sapiens_hsa030221.51911150
44Antigen processing and presentation_Homo sapiens_hsa046121.51099535
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48468433
46Folate biosynthesis_Homo sapiens_hsa007901.41749931
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41052564
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38647252
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36950323
50Asthma_Homo sapiens_hsa053101.36159954
51Vibrio cholerae infection_Homo sapiens_hsa051101.35901827
52Influenza A_Homo sapiens_hsa051641.34426606
53Synaptic vesicle cycle_Homo sapiens_hsa047211.32043554
54Peroxisome_Homo sapiens_hsa041461.31078534
55B cell receptor signaling pathway_Homo sapiens_hsa046621.30134494
56Tryptophan metabolism_Homo sapiens_hsa003801.29746350
57Mismatch repair_Homo sapiens_hsa034301.27701201
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27587139
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23055318
60Butanoate metabolism_Homo sapiens_hsa006501.22275276
61Hematopoietic cell lineage_Homo sapiens_hsa046401.21928653
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.19919220
63Mineral absorption_Homo sapiens_hsa049781.19150654
64Chemokine signaling pathway_Homo sapiens_hsa040621.17645924
65N-Glycan biosynthesis_Homo sapiens_hsa005101.17502855
66Oxidative phosphorylation_Homo sapiens_hsa001901.17301016
67Autoimmune thyroid disease_Homo sapiens_hsa053201.16243422
68Other glycan degradation_Homo sapiens_hsa005111.14424742
69TNF signaling pathway_Homo sapiens_hsa046681.11003884
70Viral myocarditis_Homo sapiens_hsa054161.10850291
71Glutathione metabolism_Homo sapiens_hsa004801.10309742
72Primary immunodeficiency_Homo sapiens_hsa053401.08808026
73Toxoplasmosis_Homo sapiens_hsa051451.08686519
74Retinol metabolism_Homo sapiens_hsa008301.08025949
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06467127
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06316225
77Herpes simplex infection_Homo sapiens_hsa051681.04611238
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03728568
79RNA degradation_Homo sapiens_hsa030181.01421459
80Steroid biosynthesis_Homo sapiens_hsa001001.00265400
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00198863
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00011918
83Phototransduction_Homo sapiens_hsa047440.98295945
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97248998
85Chemical carcinogenesis_Homo sapiens_hsa052040.97151980
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.96347500
87RNA polymerase_Homo sapiens_hsa030200.89765131
88Homologous recombination_Homo sapiens_hsa034400.89259842
89beta-Alanine metabolism_Homo sapiens_hsa004100.88741760
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88373147
91Hepatitis B_Homo sapiens_hsa051610.87386812
92Fatty acid degradation_Homo sapiens_hsa000710.87122754
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86113161
94Nicotine addiction_Homo sapiens_hsa050330.86083403
95Apoptosis_Homo sapiens_hsa042100.85782812
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85036618
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.83678256
98Caffeine metabolism_Homo sapiens_hsa002320.83432990
99Pyruvate metabolism_Homo sapiens_hsa006200.83362282
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83330186
101Circadian rhythm_Homo sapiens_hsa047100.82305718
102Alzheimers disease_Homo sapiens_hsa050100.81731202
103Parkinsons disease_Homo sapiens_hsa050120.81289099
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80801208
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.80105027
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79896341
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.77203247
108Fanconi anemia pathway_Homo sapiens_hsa034600.77005998
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75727153
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75357593
111T cell receptor signaling pathway_Homo sapiens_hsa046600.75204601
112Purine metabolism_Homo sapiens_hsa002300.74276534
113Metabolic pathways_Homo sapiens_hsa011000.73833843
114Platelet activation_Homo sapiens_hsa046110.72699382
115Long-term potentiation_Homo sapiens_hsa047200.72671257
116Nucleotide excision repair_Homo sapiens_hsa034200.71698624
117Epstein-Barr virus infection_Homo sapiens_hsa051690.71160666
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.69812426
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.66575177
120Linoleic acid metabolism_Homo sapiens_hsa005910.65542625
121Oocyte meiosis_Homo sapiens_hsa041140.64492038
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62887466
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61684670
124Olfactory transduction_Homo sapiens_hsa047400.61106759
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.61014196
126Arachidonic acid metabolism_Homo sapiens_hsa005900.60129820
127Hepatitis C_Homo sapiens_hsa051600.57762873
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57754576
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56281542
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.55222569
131Morphine addiction_Homo sapiens_hsa050320.54588469
132Protein export_Homo sapiens_hsa030600.53315493
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.52531733
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51173277
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49573978
136Serotonergic synapse_Homo sapiens_hsa047260.49153520
137Regulation of autophagy_Homo sapiens_hsa041400.49077306
138Vitamin B6 metabolism_Homo sapiens_hsa007500.48826229
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48509817
140HIF-1 signaling pathway_Homo sapiens_hsa040660.48462747
141Cardiac muscle contraction_Homo sapiens_hsa042600.47820434
142Fatty acid metabolism_Homo sapiens_hsa012120.47325758
143Ether lipid metabolism_Homo sapiens_hsa005650.46191150
144Renin secretion_Homo sapiens_hsa049240.45763213
145Circadian entrainment_Homo sapiens_hsa047130.45443201
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45332194
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45082650
148Pyrimidine metabolism_Homo sapiens_hsa002400.44925814
149Huntingtons disease_Homo sapiens_hsa050160.43392528
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41528307
151TGF-beta signaling pathway_Homo sapiens_hsa043500.41478022
152Salivary secretion_Homo sapiens_hsa049700.41258021
153Calcium signaling pathway_Homo sapiens_hsa040200.40971718
154Oxytocin signaling pathway_Homo sapiens_hsa049210.40414679
155Amoebiasis_Homo sapiens_hsa051460.39268326
156Long-term depression_Homo sapiens_hsa047300.38696647
157Arginine and proline metabolism_Homo sapiens_hsa003300.38310157
158Sphingolipid metabolism_Homo sapiens_hsa006000.36967198
159Prion diseases_Homo sapiens_hsa050200.36457780
160* Endocytosis_Homo sapiens_hsa041440.36143290
161Pancreatic cancer_Homo sapiens_hsa052120.34339767
162One carbon pool by folate_Homo sapiens_hsa006700.33701758
163Dopaminergic synapse_Homo sapiens_hsa047280.32757546
164Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32187588
165Amphetamine addiction_Homo sapiens_hsa050310.32181905
166Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30887527
167VEGF signaling pathway_Homo sapiens_hsa043700.29897764
168Renin-angiotensin system_Homo sapiens_hsa046140.28890016
169Viral carcinogenesis_Homo sapiens_hsa052030.27365490
170DNA replication_Homo sapiens_hsa030300.26702577
171Glutamatergic synapse_Homo sapiens_hsa047240.25959878

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