CAPZB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)5.31918609
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70486622
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70486622
4antigen processing and presentation of endogenous antigen (GO:0019883)4.44588070
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.22951867
6negative regulation of cell killing (GO:0031342)4.22951867
7positive regulation of lamellipodium assembly (GO:0010592)4.04730842
8actin nucleation (GO:0045010)3.86181789
9regulation of protein heterodimerization activity (GO:0043497)3.82904182
10response to peptidoglycan (GO:0032494)3.72948366
11regulation of B cell receptor signaling pathway (GO:0050855)3.60696470
12sequestering of actin monomers (GO:0042989)3.59539361
13negative regulation of erythrocyte differentiation (GO:0045647)3.58894342
14positive regulation of lamellipodium organization (GO:1902745)3.56221495
15protein localization to endosome (GO:0036010)3.44322915
16negative regulation of phagocytosis (GO:0050765)3.39810951
17positive regulation of gamma-delta T cell activation (GO:0046645)3.37272246
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36171381
19detection of other organism (GO:0098543)3.25776136
20ribosomal small subunit assembly (GO:0000028)3.24928852
21detection of bacterium (GO:0016045)3.21774976
22formation of translation preinitiation complex (GO:0001731)3.20499920
23viral transcription (GO:0019083)3.15831061
24immunoglobulin mediated immune response (GO:0016064)3.14093879
25macrophage activation involved in immune response (GO:0002281)3.13927956
26leukocyte aggregation (GO:0070486)3.13038846
27T cell apoptotic process (GO:0070231)3.12034275
28antigen processing and presentation via MHC class Ib (GO:0002475)3.06660575
29translational termination (GO:0006415)3.04819845
30stress fiber assembly (GO:0043149)2.99438716
31lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97422235
32Golgi transport vesicle coating (GO:0048200)2.97109461
33COPI coating of Golgi vesicle (GO:0048205)2.97109461
34B cell mediated immunity (GO:0019724)2.95648625
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95394046
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93444968
37type I interferon signaling pathway (GO:0060337)2.93364583
38cellular response to type I interferon (GO:0071357)2.93364583
39response to type I interferon (GO:0034340)2.88549167
40positive thymic T cell selection (GO:0045059)2.87391604
41translational elongation (GO:0006414)2.87214973
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86799356
43positive regulation of Cdc42 GTPase activity (GO:0043089)2.86329786
44morphogenesis of an endothelium (GO:0003159)2.85347171
45endothelial tube morphogenesis (GO:0061154)2.85347171
46myeloid dendritic cell differentiation (GO:0043011)2.84407369
47* barbed-end actin filament capping (GO:0051016)2.83374322
48regulation of mast cell degranulation (GO:0043304)2.80649718
49detection of external biotic stimulus (GO:0098581)2.79356074
50regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78993713
51negative thymic T cell selection (GO:0045060)2.78531578
52pentose-phosphate shunt (GO:0006098)2.78118532
53regulation of T cell tolerance induction (GO:0002664)2.77885800
54regulation of gamma-delta T cell differentiation (GO:0045586)2.77115127
55regulation of leukocyte degranulation (GO:0043300)2.76385871
56regulation of extracellular matrix disassembly (GO:0010715)2.76313052
57response to muramyl dipeptide (GO:0032495)2.76165941
58NIK/NF-kappaB signaling (GO:0038061)2.75854909
59lymphocyte apoptotic process (GO:0070227)2.75450118
60pinocytosis (GO:0006907)2.72692916
61cellular response to zinc ion (GO:0071294)2.70811719
62positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.70500287
63neutrophil activation involved in immune response (GO:0002283)2.70196585
64granulocyte activation (GO:0036230)2.69572195
65platelet aggregation (GO:0070527)2.67104557
66DNA unwinding involved in DNA replication (GO:0006268)2.66661434
67response to host (GO:0075136)2.64228307
68response to host defenses (GO:0052200)2.64228307
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64228307
70negative T cell selection (GO:0043383)2.63475814
71translational initiation (GO:0006413)2.63005145
72regulation of early endosome to late endosome transport (GO:2000641)2.62888963
73mannose metabolic process (GO:0006013)2.62524753
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.61058331
75modulation by symbiont of host cellular process (GO:0044068)2.59363052
76DNA strand elongation involved in DNA replication (GO:0006271)2.58925323
77negative regulation of cytokine production involved in immune response (GO:0002719)2.58794053
78respiratory burst (GO:0045730)2.58791760
79regulation of T-helper 2 cell differentiation (GO:0045628)2.58707511
80B cell receptor signaling pathway (GO:0050853)2.58311620
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57507544
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57091711
83response to host immune response (GO:0052572)2.57091711
84myeloid dendritic cell activation (GO:0001773)2.56269015
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55387996
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55339089
87regulation of translational termination (GO:0006449)2.54919758
88detection of molecule of bacterial origin (GO:0032490)2.54403539
89germinal center formation (GO:0002467)2.54281541
90neutrophil activation (GO:0042119)2.54022036
91amino sugar catabolic process (GO:0046348)2.53839034
92positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.52920750
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.52920203
94viral life cycle (GO:0019058)2.52130010
95protein targeting to ER (GO:0045047)2.51648984
96glycosphingolipid catabolic process (GO:0046479)2.51569928
97regulation of response to interferon-gamma (GO:0060330)2.51467418
98hepatocyte apoptotic process (GO:0097284)2.50118115
99myeloid cell activation involved in immune response (GO:0002275)2.49286035
100regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.48929411
101cotranslational protein targeting to membrane (GO:0006613)2.48409290
102leukocyte cell-cell adhesion (GO:0007159)2.48355930
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.47310457
104regulation of interleukin-2 biosynthetic process (GO:0045076)2.46843919
105positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46619519
106regulation of interferon-beta biosynthetic process (GO:0045357)2.46194739
107antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.46048323
108cellular protein complex disassembly (GO:0043624)2.45170511
109regulation of B cell differentiation (GO:0045577)2.44863971
110thymic T cell selection (GO:0045061)2.44855345
111cellular extravasation (GO:0045123)2.44791902
112regulation of necroptotic process (GO:0060544)2.44107441
113regulation of superoxide anion generation (GO:0032928)2.43606868
114detection of biotic stimulus (GO:0009595)2.43234345
115T cell migration (GO:0072678)2.43002069
116regulation of podosome assembly (GO:0071801)2.42590409
117regulation of gamma-delta T cell activation (GO:0046643)2.41852013
118regulation of mast cell activation involved in immune response (GO:0033006)2.41459724
119positive regulation of macrophage differentiation (GO:0045651)2.40965638
120regulation of tolerance induction (GO:0002643)2.40690426
121regulation of natural killer cell mediated immunity (GO:0002715)2.40407408
122regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.40407408
123negative regulation of leukocyte mediated immunity (GO:0002704)2.40242674
124DNA strand elongation (GO:0022616)2.40108937
125cellular response to thyroid hormone stimulus (GO:0097067)2.38174469
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37995568
127positive regulation of B cell differentiation (GO:0045579)2.37887090
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.37723684
129positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.37699669
130regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36555235
131virion attachment to host cell (GO:0019062)2.36511442
132adhesion of symbiont to host cell (GO:0044650)2.36511442
1333-UTR-mediated mRNA stabilization (GO:0070935)2.36328107
134protein localization to endoplasmic reticulum (GO:0070972)2.33763265
135NADPH regeneration (GO:0006740)2.33730115
136adenosine receptor signaling pathway (GO:0001973)2.33260041
137regulation of antigen processing and presentation (GO:0002577)2.33115785
138negative regulation of interleukin-12 production (GO:0032695)2.31609777
139Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.31166332
140positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30551064
141positive regulation of interferon-alpha production (GO:0032727)2.30426799
142Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.28309244
143immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.28309244
144Fc-gamma receptor signaling pathway (GO:0038094)2.28309244
145telomere maintenance via semi-conservative replication (GO:0032201)2.27281325
146negative regulation of cell size (GO:0045792)2.25814802
147activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.25768919
148positive regulation by symbiont of host defense response (GO:0052509)2.25721081
149modulation by symbiont of host defense response (GO:0052031)2.25721081
150modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25721081
151modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.25721081
152positive regulation by organism of defense response of other organism involved in symbiotic interact2.25721081
153modulation by symbiont of host immune response (GO:0052553)2.25721081
154natural killer cell differentiation (GO:0001779)2.25450281
155interferon-gamma-mediated signaling pathway (GO:0060333)2.23326974
156maturation of SSU-rRNA (GO:0030490)2.23119333
157protein complex disassembly (GO:0043241)2.22731573
158response to laminar fluid shear stress (GO:0034616)2.22715871
159regulation of defense response to virus by virus (GO:0050690)2.22255915
160angiogenesis involved in wound healing (GO:0060055)2.21470199
161negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.21235348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.34597105
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53824334
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.30652243
4MYC_22102868_ChIP-Seq_BL_Human2.77558917
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50263745
6VDR_21846776_ChIP-Seq_THP-1_Human2.41667725
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.40046383
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.38401926
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.35211595
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33296987
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22522267
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.17267253
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09375305
14* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05589946
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01321731
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99926198
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99189693
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.92340509
19* MAF_26560356_Chip-Seq_TH1_Human1.89557352
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.84536087
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83321213
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80766010
23SPI1_23547873_ChIP-Seq_NB4_Human1.76667329
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74905379
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73774782
26UTX_26944678_Chip-Seq_JUKART_Human1.69683580
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68682228
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65861772
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65159473
30MYB_26560356_Chip-Seq_TH2_Human1.65048838
31VDR_24763502_ChIP-Seq_THP-1_Human1.62549600
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62233696
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60848482
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59482063
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.57334277
36XRN2_22483619_ChIP-Seq_HELA_Human1.55720107
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54900337
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54510020
39* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53854063
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53731437
41* RUNX1_22412390_ChIP-Seq_EML_Mouse1.52087154
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51688745
43TCF7_22412390_ChIP-Seq_EML_Mouse1.50639659
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.50075167
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45526014
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45092126
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44539222
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41640290
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40412012
50MYB_26560356_Chip-Seq_TH1_Human1.39555753
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38286090
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36666969
53CLOCK_20551151_ChIP-Seq_293T_Human1.34919158
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34643494
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.34540977
56* KDM2B_26808549_Chip-Seq_DND41_Human1.33555007
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33553652
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33137263
59* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32915029
60LXR_22292898_ChIP-Seq_THP-1_Human1.32392715
61TFEB_21752829_ChIP-Seq_HELA_Human1.31674622
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31240042
63* SPI1_23127762_ChIP-Seq_K562_Human1.31221369
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31046650
65CIITA_25753668_ChIP-Seq_RAJI_Human1.30404981
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29583294
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29201702
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28018535
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.27771884
70* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27267369
71* MAF_26560356_Chip-Seq_TH2_Human1.27164324
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25902232
73* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25837658
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25042624
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.24813660
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23967641
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22750182
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22172517
79* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21410602
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20823862
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20668031
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20457552
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20284741
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19649065
85RUNX_20019798_ChIP-Seq_JUKART_Human1.17776390
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17344515
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17112131
88ATF3_27146783_Chip-Seq_COLON_Human1.15995758
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15752943
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13549217
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12745918
92* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12597856
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12394558
94* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12313608
95* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11951920
96* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11863769
97DCP1A_22483619_ChIP-Seq_HELA_Human1.11517473
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11308617
99* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11183371
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11155851
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11133118
102* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10834128
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10352125
104* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09465999
105VDR_23849224_ChIP-Seq_CD4+_Human1.09399170
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08907799
107GABP_19822575_ChIP-Seq_HepG2_Human1.08785024
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08198552
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07905837
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07694881
111SCL_19346495_ChIP-Seq_HPC-7_Human1.07179169
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07079242
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06998129
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06901295
115RACK7_27058665_Chip-Seq_MCF-7_Human1.06894589
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.05039140
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.04988553
118PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04858935
119KDM2B_26808549_Chip-Seq_K562_Human1.04706062
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03410069
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03021857
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02929502
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02026459
124ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01781870
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01532965
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.01503512
127GATA1_19941826_ChIP-Seq_K562_Human1.01487890
128HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01138349
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00955402
130BCOR_27268052_Chip-Seq_Bcells_Human1.00937160
131BCL6_27268052_Chip-Seq_Bcells_Human1.00802457
132FOXP3_21729870_ChIP-Seq_TREG_Human1.00733460
133ESR2_21235772_ChIP-Seq_MCF-7_Human1.00657684
134ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00189341
135* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00074503
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99910270
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99203095
138NCOR1_26117541_ChIP-Seq_K562_Human0.98417013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation2.90088764
2MP0001835_abnormal_antigen_presentation2.82542612
3MP0003436_decreased_susceptibility_to2.68778003
4MP0010352_gastrointestinal_tract_polyps2.52707468
5MP0003705_abnormal_hypodermis_morpholog2.47257702
6MP0000685_abnormal_immune_system2.39143985
7MP0005451_abnormal_body_composition2.22531381
8MP0003566_abnormal_cell_adhesion2.20731033
9MP0009785_altered_susceptibility_to2.05432516
10MP0002396_abnormal_hematopoietic_system2.04197624
11MP0001800_abnormal_humoral_immune2.04161987
12MP0005000_abnormal_immune_tolerance2.02204474
13MP0002452_abnormal_antigen_presenting2.02148779
14MP0009333_abnormal_splenocyte_physiolog2.02065537
15MP0005671_abnormal_response_to2.00106339
16MP0006054_spinal_hemorrhage1.99766492
17MP0000858_altered_metastatic_potential1.98449697
18MP0003300_gastrointestinal_ulcer1.91749500
19MP0005025_abnormal_response_to1.90804516
20MP0008438_abnormal_cutaneous_collagen1.90110245
21MP0002420_abnormal_adaptive_immunity1.90039935
22MP0001819_abnormal_immune_cell1.89285392
23MP0008260_abnormal_autophagy1.89247818
24MP0005387_immune_system_phenotype1.88643497
25MP0001790_abnormal_immune_system1.88643497
26MP0003279_aneurysm1.83970715
27MP0002398_abnormal_bone_marrow1.83081009
28MP0002419_abnormal_innate_immunity1.82599432
29MP0003763_abnormal_thymus_physiology1.81289553
30MP0002148_abnormal_hypersensitivity_rea1.81284899
31MP0002405_respiratory_system_inflammati1.79545163
32MP0002723_abnormal_immune_serum1.77130295
33MP0004808_abnormal_hematopoietic_stem1.75049447
34MP0005058_abnormal_lysosome_morphology1.72836194
35MP0005023_abnormal_wound_healing1.71072421
36MP0003693_abnormal_embryo_hatching1.68551457
37MP0000343_altered_response_to1.61929810
38MP0001533_abnormal_skeleton_physiology1.59995786
39MP0000716_abnormal_immune_system1.59962520
40MP0005397_hematopoietic_system_phenotyp1.59871551
41MP0001545_abnormal_hematopoietic_system1.59871551
42MP0001853_heart_inflammation1.58459660
43MP0009278_abnormal_bone_marrow1.58428038
44MP0004957_abnormal_blastocyst_morpholog1.56554931
45MP0000490_abnormal_crypts_of1.56486762
46MP0005464_abnormal_platelet_physiology1.55035132
47MP0002722_abnormal_immune_system1.55004176
48MP0002166_altered_tumor_susceptibility1.52496004
49MP0000689_abnormal_spleen_morphology1.50547255
50MP0010155_abnormal_intestine_physiology1.49876576
51MP0002429_abnormal_blood_cell1.48000532
52MP0005076_abnormal_cell_differentiation1.45957204
53MP0004947_skin_inflammation1.44587284
54MP0001849_ear_inflammation1.43855689
55MP0002254_reproductive_system_inflammat1.42936729
56MP0003448_altered_tumor_morphology1.42360213
57MP0006082_CNS_inflammation1.40279586
58MP0001542_abnormal_bone_strength1.35888493
59MP0010307_abnormal_tumor_latency1.35284741
60MP0003724_increased_susceptibility_to1.35002710
61MP0004510_myositis1.34017430
62MP0008004_abnormal_stomach_pH1.31302688
63MP0001845_abnormal_inflammatory_respons1.30673213
64MP0000703_abnormal_thymus_morphology1.29189558
65MP0003077_abnormal_cell_cycle1.27262793
66MP0008007_abnormal_cellular_replicative1.25196499
67MP0003453_abnormal_keratinocyte_physiol1.24543319
68MP0005257_abnormal_intraocular_pressure1.24402755
69MP0000604_amyloidosis1.23322040
70MP0002006_tumorigenesis1.19346978
71MP0005166_decreased_susceptibility_to1.18691628
72MP0002019_abnormal_tumor_incidence1.17089806
73MP0001958_emphysema1.16724244
74MP0003172_abnormal_lysosome_physiology1.15743959
75MP0002933_joint_inflammation1.15517534
76MP0004084_abnormal_cardiac_muscle1.15430557
77MP0003111_abnormal_nucleus_morphology1.14845591
78MP0003828_pulmonary_edema1.13636152
79MP0004858_abnormal_nervous_system1.13522942
80MP0000465_gastrointestinal_hemorrhage1.11426070
81MP0000750_abnormal_muscle_regeneration1.10934382
82MP0003866_abnormal_defecation1.10090815
83MP0009764_decreased_sensitivity_to1.09424651
84MP0003091_abnormal_cell_migration1.09034823
85MP0001873_stomach_inflammation1.04442537
86MP0002877_abnormal_melanocyte_morpholog1.04057203
87MP0003183_abnormal_peptide_metabolism1.01289934
88MP0005165_increased_susceptibility_to1.00821892
89MP0000350_abnormal_cell_proliferation0.99165533
90MP0005275_abnormal_skin_tensile0.97292167
91MP0001851_eye_inflammation0.97284830
92MP0001730_embryonic_growth_arrest0.94013393
93MP0000733_abnormal_muscle_development0.93470463
94MP0003795_abnormal_bone_structure0.93301443
95MP0010094_abnormal_chromosome_stability0.90673204
96MP0003221_abnormal_cardiomyocyte_apopto0.88772753
97MP0000358_abnormal_cell_content/0.87801337
98MP0009840_abnormal_foam_cell0.86127454
99MP0005310_abnormal_salivary_gland0.85887319
100MP0009763_increased_sensitivity_to0.85696452
101MP0005164_abnormal_response_to0.85496423
102MP0003806_abnormal_nucleotide_metabolis0.85155375
103MP0005390_skeleton_phenotype0.84549505
104MP0008469_abnormal_protein_level0.84267763
105MP0003191_abnormal_cellular_cholesterol0.83783932
106MP0000249_abnormal_blood_vessel0.82935062
107MP0003329_amyloid_beta_deposits0.82592086
108MP0004883_abnormal_blood_vessel0.81359415
109MP0000313_abnormal_cell_death0.80891803
110MP0004087_abnormal_muscle_fiber0.79341039
111MP0001663_abnormal_digestive_system0.77543098
112MP0001915_intracranial_hemorrhage0.77125355
113MP0001348_abnormal_lacrimal_gland0.76393254
114MP0000767_abnormal_smooth_muscle0.74886259
115MP0010630_abnormal_cardiac_muscle0.73863601
116MP0008874_decreased_physiological_sensi0.73614133
117MP0002998_abnormal_bone_remodeling0.72580027
118MP0002080_prenatal_lethality0.72231055
119MP0005621_abnormal_cell_physiology0.72134451
120MP0000477_abnormal_intestine_morphology0.71433876
121MP0004272_abnormal_basement_membrane0.70195775
122MP0001243_abnormal_dermal_layer0.68808147
123MP0001697_abnormal_embryo_size0.68562802
124MP0004185_abnormal_adipocyte_glucose0.68009617
125MP0003075_altered_response_to0.67669063
126MP0003984_embryonic_growth_retardation0.66863608
127MP0002132_abnormal_respiratory_system0.66607240
128MP0002060_abnormal_skin_morphology0.66162409
129MP0000749_muscle_degeneration0.66097408

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.05235440
2Elevated erythrocyte sedimentation rate (HP:0003565)3.70581313
3Recurrent abscess formation (HP:0002722)3.69610505
4Protrusio acetabuli (HP:0003179)3.57801508
5Cellulitis (HP:0100658)3.04135875
6Abnormality of the nasal mucosa (HP:0000433)3.03250878
7Systemic lupus erythematosus (HP:0002725)3.02745754
8Purpura (HP:0000979)2.98498564
9Thrombocytosis (HP:0001894)2.97846710
10Nasal polyposis (HP:0100582)2.97155910
11Recurrent bacterial skin infections (HP:0005406)2.96722941
12Cerebral aneurysm (HP:0004944)2.96573742
13Vertebral compression fractures (HP:0002953)2.79116598
14Increased density of long bones (HP:0006392)2.78594737
15IgM deficiency (HP:0002850)2.75786006
16Chronic otitis media (HP:0000389)2.75605890
17Loss of speech (HP:0002371)2.75382872
18Interstitial pulmonary disease (HP:0006530)2.72974172
19Increased cerebral lipofuscin (HP:0011813)2.71039677
20Myositis (HP:0100614)2.70171893
21Recurrent bronchitis (HP:0002837)2.65713402
22Recurrent fungal infections (HP:0002841)2.62888787
23Aortic aneurysm (HP:0004942)2.61105880
24Premature rupture of membranes (HP:0001788)2.50082147
25Recurrent viral infections (HP:0004429)2.48043225
26Axonal loss (HP:0003447)2.43316236
27Petechiae (HP:0000967)2.41989131
28Cervical subluxation (HP:0003308)2.41423287
29Ulnar deviation of the wrist (HP:0003049)2.37723921
30Autoimmune thrombocytopenia (HP:0001973)2.36952577
31Vacuolated lymphocytes (HP:0001922)2.36204405
32Abnormality of macrophages (HP:0004311)2.35336641
33Prolonged bleeding time (HP:0003010)2.34553148
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.33543002
35Peritonitis (HP:0002586)2.33408626
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.31631084
37Stomatitis (HP:0010280)2.29555358
38Verrucae (HP:0200043)2.29414658
39Papilloma (HP:0012740)2.29414658
40Spondylolisthesis (HP:0003302)2.28895369
41Pustule (HP:0200039)2.28358719
42Mediastinal lymphadenopathy (HP:0100721)2.27172062
43Abnormality of skeletal muscle fiber size (HP:0012084)2.27149297
44Distal lower limb muscle weakness (HP:0009053)2.26522989
45Obstructive lung disease (HP:0006536)2.25514967
46Chronic obstructive pulmonary disease (HP:0006510)2.25514967
47Epistaxis (HP:0000421)2.25281430
48Dysostosis multiplex (HP:0000943)2.24338575
49Dilatation of the ascending aorta (HP:0005111)2.23380114
50Abnormality of polysaccharide metabolism (HP:0011012)2.20307815
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20307815
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20307815
53Hepatosplenomegaly (HP:0001433)2.17810692
54Aortic dissection (HP:0002647)2.17506157
55Abnormality of T cell physiology (HP:0011840)2.17151111
56Nuclear cataract (HP:0100018)2.16380805
57Degeneration of anterior horn cells (HP:0002398)2.15314442
58Abnormality of the anterior horn cell (HP:0006802)2.15314442
59Amyloidosis (HP:0011034)2.15052137
60Increased variability in muscle fiber diameter (HP:0003557)2.14550686
61Abnormality of T cells (HP:0002843)2.13072372
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11582733
63Increased IgM level (HP:0003496)2.11506364
64Distal lower limb amyotrophy (HP:0008944)2.11499253
65Asymmetric septal hypertrophy (HP:0001670)2.09724626
66Vasculitis (HP:0002633)2.07453261
67Optic neuritis (HP:0100653)2.06437685
68Retrobulbar optic neuritis (HP:0100654)2.06437685
69Multiple enchondromatosis (HP:0005701)2.06024825
70Emphysema (HP:0002097)2.03879525
71Abnormal platelet volume (HP:0011876)2.03041632
72Trismus (HP:0000211)2.02949302
73Joint stiffness (HP:0001387)2.00405052
74Agnosia (HP:0010524)2.00206870
75Gingival bleeding (HP:0000225)1.99496946
76Frequent falls (HP:0002359)1.98615273
77Hypertensive crisis (HP:0100735)1.98564139
78Recurrent gram-negative bacterial infections (HP:0005420)1.98354392
79Urticaria (HP:0001025)1.97044862
80Increased connective tissue (HP:0009025)1.97028911
81Gastrointestinal infarctions (HP:0005244)1.96780853
82Spontaneous hematomas (HP:0007420)1.95916829
83Bicuspid aortic valve (HP:0001647)1.95548372
84Myocardial infarction (HP:0001658)1.95015384
85Abnormality of cells of the lymphoid lineage (HP:0012140)1.94001603
86Spinal rigidity (HP:0003306)1.93633811
87Gastrointestinal inflammation (HP:0004386)1.93318718
88Slender build (HP:0001533)1.92978878
89Progressive neurologic deterioration (HP:0002344)1.91446399
90Increased IgE level (HP:0003212)1.88636409
91Pulmonary infiltrates (HP:0002113)1.87734158
92Achilles tendon contracture (HP:0001771)1.87668754
93Skin ulcer (HP:0200042)1.87596263
94Poor head control (HP:0002421)1.87335867
95Osteomyelitis (HP:0002754)1.87197720
96T lymphocytopenia (HP:0005403)1.87066934
97Abnormality of liposaccharide metabolism (HP:0010968)1.86843965
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.86843965
99Abnormality of glycolipid metabolism (HP:0010969)1.86843965
100Abnormality of the calcaneus (HP:0008364)1.86746476
101Chest pain (HP:0100749)1.86517424
102Lymphopenia (HP:0001888)1.86361338
103Meningitis (HP:0001287)1.85713478
104Increased serum ferritin (HP:0003281)1.84251250
105Difficulty climbing stairs (HP:0003551)1.84191267
106Distal arthrogryposis (HP:0005684)1.84037111
107Limb-girdle muscle atrophy (HP:0003797)1.83958275
108Urinary glycosaminoglycan excretion (HP:0003541)1.83845550
109Mucopolysacchariduria (HP:0008155)1.83845550
110Recurrent skin infections (HP:0001581)1.82738088
111Polygenic inheritance (HP:0010982)1.82727969
112Gastrointestinal stroma tumor (HP:0100723)1.81990661
113Shallow orbits (HP:0000586)1.80951994
114Osteolytic defects of the hand bones (HP:0009699)1.80524930
115Osteolytic defects of the phalanges of the hand (HP:0009771)1.80524930
116Blue sclerae (HP:0000592)1.80336172
117Premature loss of primary teeth (HP:0006323)1.78775237
118Upper motor neuron abnormality (HP:0002127)1.78649810
119Inflammation of the large intestine (HP:0002037)1.77280507
120Hand muscle atrophy (HP:0009130)1.77173472
121Gastrointestinal dysmotility (HP:0002579)1.77091807
122Myopathic facies (HP:0002058)1.75570571
123Ankle contracture (HP:0006466)1.74709486
124Restrictive lung disease (HP:0002091)1.74477293
125Genu recurvatum (HP:0002816)1.74306854
126Hematochezia (HP:0002573)1.74145133
127Abnormality of the Achilles tendon (HP:0005109)1.72863274
128Hypergammaglobulinemia (HP:0010702)1.72740506
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.72640440
130Ventricular tachycardia (HP:0004756)1.72478025
131Gingivitis (HP:0000230)1.72471964
132Leukocytosis (HP:0001974)1.72041954
133Aneurysm (HP:0002617)1.71551751
134Vascular tortuosity (HP:0004948)1.70864741
135Diminished motivation (HP:0000745)1.70797345
136Cholecystitis (HP:0001082)1.70695419
137Abnormal gallbladder physiology (HP:0012438)1.70695419
138Hypercortisolism (HP:0001578)1.70108689
139Neoplasm of head and neck (HP:0012288)1.69156379
140Esophageal neoplasm (HP:0100751)1.69156379
141Abnormality of T cell number (HP:0011839)1.68281299
142Orchitis (HP:0100796)1.66628336
143Basal ganglia calcification (HP:0002135)1.66510001
144Selective tooth agenesis (HP:0001592)1.66080004
145Angiofibromas (HP:0010615)1.65603783
146Adenoma sebaceum (HP:0009720)1.65603783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.54186912
2TESK23.22264499
3MAP4K13.17257066
4TESK12.96278996
5PRPF4B2.82393823
6PKN22.72641457
7ERN12.64714846
8STK102.28026918
9SMG12.25347429
10BLK2.24372666
11PIM22.23832194
12KDR2.15840633
13LRRK22.12833791
14IRAK32.07315703
15NME22.05770296
16EEF2K2.03566453
17ZAP702.01223137
18TTN1.98327899
19PAK41.80190239
20MAP3K141.78998036
21MAP3K131.77558050
22TBK11.73476993
23RPS6KA41.70111845
24MAP3K101.69491813
25MAPKAPK31.68423986
26LIMK11.68403058
27MAP2K31.59102457
28SCYL21.57215298
29MAP3K111.56160293
30BUB11.49209416
31TYK21.49073198
32JAK31.49045155
33EIF2AK11.47793141
34NEK11.45371186
35DDR21.41449726
36ARAF1.39177813
37CDC42BPA1.34388226
38BTK1.32988426
39KIT1.32610530
40SIK11.26924015
41SIK31.25077785
42GRK61.24717902
43ILK1.22299769
44RPS6KB21.21415167
45MOS1.16624258
46TGFBR21.15731485
47FLT31.15623580
48FGR1.14570939
49MAP3K81.08572728
50NEK91.08266430
51MAP3K11.05430861
52KSR21.00020969
53CSF1R0.97707883
54SYK0.95699217
55ITK0.94613778
56PTK60.93430288
57MYLK0.93269773
58PRKD20.92384487
59CSK0.92365718
60NEK20.90433359
61TAOK10.90369525
62DMPK0.89086516
63TGFBR10.87402415
64TXK0.85322682
65TNK20.85143531
66ICK0.80550723
67HCK0.79985439
68TEC0.79438709
69MAP3K120.79422936
70RIPK10.79367710
71DAPK30.76738341
72TAOK20.76226609
73ALK0.76010646
74LCK0.73657102
75MATK0.73547623
76PIM10.72818450
77PAK10.69503277
78GRK70.67670356
79JAK10.67306578
80CDC70.66584454
81FGFR40.66451819
82PDPK10.65984839
83IKBKE0.65797387
84WEE10.65356368
85MAPKAPK20.62610647
86CDK40.62206066
87MAP3K30.62194823
88IKBKB0.61296230
89IRAK40.59515145
90EPHB10.59162597
91CDK60.58331203
92PAK20.56560096
93MARK20.55859920
94LYN0.55049773
95PIK3CG0.54337017
96PDK10.53453958
97PRKG20.52708941
98MAP3K50.51785481
99EIF2AK30.51013847
100RPS6KA20.50601933
101MST40.49627991
102TSSK60.49256604
103BMX0.48974076
104EPHA20.48434248
105ROCK20.47519820
106PTK20.46903856
107ABL20.46439430
108CLK10.45865611
109HIPK20.45480875
110MARK30.45346346
111VRK20.45221954
112TRPM70.45200917
113DAPK10.45137638
114MAP3K60.44673989
115RIPK40.42909975
116FES0.42775227
117RPS6KL10.42712379
118RPS6KC10.42712379
119CDK70.42222828
120FYN0.41707215
121PDGFRB0.41386721
122BMPR20.40781605
123ACVR1B0.38219634
124JAK20.34812626
125CDK120.33912797
126PDGFRA0.33630738
127AURKB0.33532776
128RPS6KA60.32700572
129STK40.30865281
130CHUK0.30198704
131STK240.29598559
132MAP2K60.28224044

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.48184387
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30374600
3Leishmaniasis_Homo sapiens_hsa051402.24202968
4Shigellosis_Homo sapiens_hsa051312.19712160
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.09865732
6Antigen processing and presentation_Homo sapiens_hsa046122.08584701
7Proteasome_Homo sapiens_hsa030502.04194080
8Ribosome_Homo sapiens_hsa030102.02725292
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.01308786
10Primary immunodeficiency_Homo sapiens_hsa053401.94690128
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75023766
12Autoimmune thyroid disease_Homo sapiens_hsa053201.73874736
13Viral myocarditis_Homo sapiens_hsa054161.73857387
14Legionellosis_Homo sapiens_hsa051341.68008620
15B cell receptor signaling pathway_Homo sapiens_hsa046621.64044963
16Mismatch repair_Homo sapiens_hsa034301.63148294
17Osteoclast differentiation_Homo sapiens_hsa043801.60302329
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.60168131
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51445198
20Measles_Homo sapiens_hsa051621.49002988
21Base excision repair_Homo sapiens_hsa034101.48641582
22Apoptosis_Homo sapiens_hsa042101.44776153
23Salmonella infection_Homo sapiens_hsa051321.43905639
24Pertussis_Homo sapiens_hsa051331.36076520
25Toxoplasmosis_Homo sapiens_hsa051451.34928221
26Rheumatoid arthritis_Homo sapiens_hsa053231.31499326
27Other glycan degradation_Homo sapiens_hsa005111.30578463
28p53 signaling pathway_Homo sapiens_hsa041151.29254940
29Chronic myeloid leukemia_Homo sapiens_hsa052201.27260558
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.26574082
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.25729445
32Tuberculosis_Homo sapiens_hsa051521.24731725
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21997944
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21721825
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21090334
36Type I diabetes mellitus_Homo sapiens_hsa049401.20968638
37Acute myeloid leukemia_Homo sapiens_hsa052211.20694363
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20617794
39Epstein-Barr virus infection_Homo sapiens_hsa051691.20070019
40Lysosome_Homo sapiens_hsa041421.19986253
41Hematopoietic cell lineage_Homo sapiens_hsa046401.19748180
42Prion diseases_Homo sapiens_hsa050201.19491786
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.18098061
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17441551
45Herpes simplex infection_Homo sapiens_hsa051681.15971641
46Hepatitis B_Homo sapiens_hsa051611.15593602
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14784396
48Spliceosome_Homo sapiens_hsa030401.13057921
49Cell cycle_Homo sapiens_hsa041101.12838172
50T cell receptor signaling pathway_Homo sapiens_hsa046601.10268651
51Pentose phosphate pathway_Homo sapiens_hsa000301.08036665
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.05049115
53VEGF signaling pathway_Homo sapiens_hsa043701.03940321
54HIF-1 signaling pathway_Homo sapiens_hsa040661.03591220
55HTLV-I infection_Homo sapiens_hsa051661.02157182
56Platelet activation_Homo sapiens_hsa046111.00781591
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00234717
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00105277
59Influenza A_Homo sapiens_hsa051640.99740279
60TNF signaling pathway_Homo sapiens_hsa046680.99356224
61Pancreatic cancer_Homo sapiens_hsa052120.98235181
62Viral carcinogenesis_Homo sapiens_hsa052030.97432635
63RNA transport_Homo sapiens_hsa030130.97161626
64Small cell lung cancer_Homo sapiens_hsa052220.96055740
65Malaria_Homo sapiens_hsa051440.95271167
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95254095
67Proteoglycans in cancer_Homo sapiens_hsa052050.90953251
68Bladder cancer_Homo sapiens_hsa052190.90390153
69Phagosome_Homo sapiens_hsa041450.89876333
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.88507082
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87668268
72Vibrio cholerae infection_Homo sapiens_hsa051100.85153973
73Nucleotide excision repair_Homo sapiens_hsa034200.85106862
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85101947
75Focal adhesion_Homo sapiens_hsa045100.84290349
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84165789
77Renal cell carcinoma_Homo sapiens_hsa052110.82100399
78Thyroid cancer_Homo sapiens_hsa052160.81923079
79Notch signaling pathway_Homo sapiens_hsa043300.80972014
80Chemokine signaling pathway_Homo sapiens_hsa040620.80068403
81Colorectal cancer_Homo sapiens_hsa052100.78902281
82African trypanosomiasis_Homo sapiens_hsa051430.78519021
83Fructose and mannose metabolism_Homo sapiens_hsa000510.77662620
84Adherens junction_Homo sapiens_hsa045200.76853790
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76225062
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74366218
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.73944059
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73861174
89* Endocytosis_Homo sapiens_hsa041440.72558219
90Graft-versus-host disease_Homo sapiens_hsa053320.72085644
91Amoebiasis_Homo sapiens_hsa051460.69851753
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.68127735
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66747454
94Non-small cell lung cancer_Homo sapiens_hsa052230.66368122
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65864574
96Allograft rejection_Homo sapiens_hsa053300.65704958
97Homologous recombination_Homo sapiens_hsa034400.65636555
98Galactose metabolism_Homo sapiens_hsa000520.64031515
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63495271
100Endometrial cancer_Homo sapiens_hsa052130.61268077
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59232149
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.57839081
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57424463
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57233464
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56918532
106mTOR signaling pathway_Homo sapiens_hsa041500.53541061
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53398190
108MicroRNAs in cancer_Homo sapiens_hsa052060.53334803
109Asthma_Homo sapiens_hsa053100.52951536
110Staphylococcus aureus infection_Homo sapiens_hsa051500.52572510
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52211915
112Pyrimidine metabolism_Homo sapiens_hsa002400.51635895
113One carbon pool by folate_Homo sapiens_hsa006700.51221289
114Carbon metabolism_Homo sapiens_hsa012000.49226670
115Glioma_Homo sapiens_hsa052140.48485840
116Hepatitis C_Homo sapiens_hsa051600.47651447
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.46385058
118Prostate cancer_Homo sapiens_hsa052150.44917583
119N-Glycan biosynthesis_Homo sapiens_hsa005100.44652843
120Rap1 signaling pathway_Homo sapiens_hsa040150.44479638
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44043184
122GnRH signaling pathway_Homo sapiens_hsa049120.43880079
123Prolactin signaling pathway_Homo sapiens_hsa049170.43796941
124Insulin signaling pathway_Homo sapiens_hsa049100.38795718

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »