CARD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.19289372
2antigen processing and presentation of endogenous antigen (GO:0019883)6.79083406
3positive thymic T cell selection (GO:0045059)6.29693483
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.22453002
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.22453002
6regulation of gamma-delta T cell differentiation (GO:0045586)6.05651858
7negative T cell selection (GO:0043383)5.96629744
8negative thymic T cell selection (GO:0045060)5.96307864
9regulation of B cell receptor signaling pathway (GO:0050855)5.94958168
10negative regulation of cell killing (GO:0031342)5.71103049
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.71103049
12regulation of gamma-delta T cell activation (GO:0046643)5.59521677
13B cell receptor signaling pathway (GO:0050853)5.49212310
14response to interleukin-15 (GO:0070672)5.42767059
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.36981727
16positive T cell selection (GO:0043368)5.36016075
17cellular response to interleukin-15 (GO:0071350)5.06563905
18* thymic T cell selection (GO:0045061)4.78116636
19leukocyte aggregation (GO:0070486)4.66871485
20interferon-gamma production (GO:0032609)4.65337581
21* T cell selection (GO:0045058)4.56888322
22T cell migration (GO:0072678)4.48046623
23tolerance induction (GO:0002507)4.41268543
24* regulation of B cell differentiation (GO:0045577)4.21123756
25regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.17366206
26regulation of T cell tolerance induction (GO:0002664)4.15314232
27regulation of interleukin-12 biosynthetic process (GO:0045075)4.15022055
28positive regulation of B cell differentiation (GO:0045579)4.14170199
29* antigen receptor-mediated signaling pathway (GO:0050851)4.13211410
30regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.07929920
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94840323
32regulation of alpha-beta T cell proliferation (GO:0046640)3.84629108
33negative regulation of T cell mediated immunity (GO:0002710)3.84349840
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.81305161
35* T cell costimulation (GO:0031295)3.79688849
36* T cell receptor signaling pathway (GO:0050852)3.78808544
37regulation of isotype switching to IgG isotypes (GO:0048302)3.77847646
38* positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76812812
39detection of bacterium (GO:0016045)3.74781945
40cellular response to zinc ion (GO:0071294)3.72029335
41* lymphocyte costimulation (GO:0031294)3.71950146
42positive regulation of granulocyte differentiation (GO:0030854)3.66118513
43detection of other organism (GO:0098543)3.62428991
44mature B cell differentiation (GO:0002335)3.54748636
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.54259391
46negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.53752563
47regulation of interferon-beta biosynthetic process (GO:0045357)3.52006999
48activated T cell proliferation (GO:0050798)3.51695072
49regulation of T cell receptor signaling pathway (GO:0050856)3.48572785
50negative regulation of leukocyte mediated immunity (GO:0002704)3.47555491
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.45843848
52positive regulation of isotype switching (GO:0045830)3.43968789
53* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.40806765
54regulation of natural killer cell mediated immunity (GO:0002715)3.40609780
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.40609780
56* positive regulation of interleukin-2 production (GO:0032743)3.39196281
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.38314737
58negative regulation of T-helper cell differentiation (GO:0045623)3.38314737
59NIK/NF-kappaB signaling (GO:0038061)3.36329402
60macrophage activation involved in immune response (GO:0002281)3.32701135
61B cell proliferation (GO:0042100)3.31934047
62CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.31865526
63positive regulation of tolerance induction (GO:0002645)3.27539810
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27219304
65leukocyte cell-cell adhesion (GO:0007159)3.26855166
66T cell homeostasis (GO:0043029)3.26209545
67lymphocyte homeostasis (GO:0002260)3.24232080
68Peyers patch development (GO:0048541)3.23279079
69mucosal-associated lymphoid tissue development (GO:0048537)3.23279079
70germinal center formation (GO:0002467)3.22954069
71antigen processing and presentation via MHC class Ib (GO:0002475)3.20870072
72mast cell activation (GO:0045576)3.20322026
73interferon-gamma-mediated signaling pathway (GO:0060333)3.19698827
74immunoglobulin mediated immune response (GO:0016064)3.19662290
75positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18665336
76negative regulation of erythrocyte differentiation (GO:0045647)3.16234358
77regulation of tolerance induction (GO:0002643)3.10206143
78regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09145329
79B cell homeostasis (GO:0001782)3.08417872
80myeloid dendritic cell activation (GO:0001773)3.08063569
81natural killer cell differentiation (GO:0001779)3.07497091
82regulation of response to interferon-gamma (GO:0060330)3.06756953
83regulation of T cell mediated cytotoxicity (GO:0001914)3.05958405
84positive regulation by symbiont of host defense response (GO:0052509)3.05895899
85modulation by symbiont of host defense response (GO:0052031)3.05895899
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05895899
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05895899
88positive regulation by organism of defense response of other organism involved in symbiotic interact3.05895899
89modulation by symbiont of host immune response (GO:0052553)3.05895899
90positive regulation of immunoglobulin production (GO:0002639)3.05655125
91negative regulation of phagocytosis (GO:0050765)3.04988575
92positive regulation of histone deacetylation (GO:0031065)3.04386121
93cellular extravasation (GO:0045123)3.03994254
94response to protozoan (GO:0001562)3.03656886
95regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.02849925
96* regulation of B cell proliferation (GO:0030888)3.00482930
97response to muramyl dipeptide (GO:0032495)2.98978498
98natural killer cell activation (GO:0030101)2.98925668
99negative regulation of alpha-beta T cell activation (GO:0046636)2.98207531
100histone H3-K36 demethylation (GO:0070544)2.97904030
101T cell proliferation (GO:0042098)2.96894734
102regulation of alpha-beta T cell activation (GO:0046634)2.96329005
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95357088
104positive regulation of DNA recombination (GO:0045911)2.92594541
105regulation of regulatory T cell differentiation (GO:0045589)2.92056184
106B cell mediated immunity (GO:0019724)2.91708280
107positive regulation of antigen processing and presentation (GO:0002579)2.91538722
108negative regulation of type 2 immune response (GO:0002829)2.90985806
109regulation of antigen processing and presentation (GO:0002577)2.90812940
110positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90520595
111negative regulation of interleukin-12 production (GO:0032695)2.90245124
112lymphocyte migration (GO:0072676)2.90215188
113regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89685163
114neutrophil activation involved in immune response (GO:0002283)2.89517966
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89289903
116signal complex assembly (GO:0007172)2.88007772
117regulation of isotype switching (GO:0045191)2.87645488
118positive regulation of interferon-alpha production (GO:0032727)2.87640688
119positive regulation of humoral immune response (GO:0002922)2.87265362
120positive regulation of immunoglobulin mediated immune response (GO:0002891)2.86397416
121positive regulation of B cell mediated immunity (GO:0002714)2.86397416
122response to type I interferon (GO:0034340)2.85548836
123* regulation of interleukin-2 biosynthetic process (GO:0045076)2.83462295
124negative regulation of T cell receptor signaling pathway (GO:0050860)2.82234582
125regulation of B cell mediated immunity (GO:0002712)2.82196778
126* positive regulation of B cell activation (GO:0050871)2.81842366
127mast cell degranulation (GO:0043303)2.81386674
128mast cell activation involved in immune response (GO:0002279)2.81386674
129mononuclear cell proliferation (GO:0032943)2.80101295
130myeloid dendritic cell differentiation (GO:0043011)2.80048530
131negative regulation of B cell proliferation (GO:0030889)2.77350040
132type I interferon signaling pathway (GO:0060337)2.77273003
133cellular response to type I interferon (GO:0071357)2.77273003
134defense response to protozoan (GO:0042832)2.76573549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.97741041
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.34923889
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.09289676
4MYC_22102868_ChIP-Seq_BL_Human4.09159784
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.86630698
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.49432654
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30880151
8E2F7_22180533_ChIP-Seq_HELA_Human3.29915606
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.29356892
10RUNX_20019798_ChIP-Seq_JUKART_Human3.21895900
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.20025781
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.17425161
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13279757
14VDR_21846776_ChIP-Seq_THP-1_Human2.93799011
15MYB_26560356_Chip-Seq_TH2_Human2.92752560
16MAF_26560356_Chip-Seq_TH1_Human2.83395406
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77220869
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.76169953
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.71304446
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69584339
21MYB_26560356_Chip-Seq_TH1_Human2.62739431
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53957910
23UTX_26944678_Chip-Seq_JUKART_Human2.52569758
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.44443576
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35826965
26TCF7_22412390_ChIP-Seq_EML_Mouse2.25719623
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.19396593
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17383492
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15721675
30* VDR_24763502_ChIP-Seq_THP-1_Human2.12260747
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11962506
32SPI1_23547873_ChIP-Seq_NB4_Human2.08700956
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.06495845
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02523352
35MAF_26560356_Chip-Seq_TH2_Human1.96954584
36SCL_19346495_ChIP-Seq_HPC-7_Human1.96121999
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94348522
38KDM2B_26808549_Chip-Seq_DND41_Human1.91808487
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91678885
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.85950039
41GATA3_27048872_Chip-Seq_THYMUS_Human1.82613713
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82293365
43* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76719201
44SPI1_23127762_ChIP-Seq_K562_Human1.76617345
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76590257
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69571053
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60475716
48CIITA_25753668_ChIP-Seq_RAJI_Human1.51707979
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50350312
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.48880943
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48143354
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.43402080
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38154226
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35558010
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33839153
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27541166
57PU_27001747_Chip-Seq_BMDM_Mouse1.26585831
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22825838
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21991177
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21106961
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20597902
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20018807
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19508678
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.14992488
65GATA3_26560356_Chip-Seq_TH2_Human1.13137300
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12831393
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12373331
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08550785
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07137835
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06544250
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05026571
72GATA1_22025678_ChIP-Seq_K562_Human1.04828159
73GATA1_19941826_ChIP-Seq_K562_Human1.03835821
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03009223
75BCOR_27268052_Chip-Seq_Bcells_Human1.00552403
76GATA1_19941827_ChIP-Seq_MEL_Mouse0.99089093
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98954791
78NCOR1_26117541_ChIP-Seq_K562_Human0.94029239
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93593475
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92960752
81LXR_22292898_ChIP-Seq_THP-1_Human0.91706891
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.90565999
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90448958
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90366804
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89969503
86SA1_27219007_Chip-Seq_ERYTHROID_Human0.89575881
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87535648
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85931136
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85410961
90SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83276509
91* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82469275
92RACK7_27058665_Chip-Seq_MCF-7_Human0.81360127
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80850504
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80695603
95P68_20966046_ChIP-Seq_HELA_Human0.79769947
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78702006
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78319088
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78123591
99CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77729548
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77592744
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76562843
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.73612390
103* VDR_24787735_ChIP-Seq_THP-1_Human0.73570000
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72875944
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72808897
106BCL6_27268052_Chip-Seq_Bcells_Human0.72320232
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.72252695
108GATA2_19941826_ChIP-Seq_K562_Human0.72173182
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.71018219
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69794086
111P300_27268052_Chip-Seq_Bcells_Human0.69661254
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.69269143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.48229245
2* MP0001800_abnormal_humoral_immune3.94415811
3MP0003763_abnormal_thymus_physiology3.88049690
4* MP0001790_abnormal_immune_system3.87884735
5* MP0005387_immune_system_phenotype3.87884735
6MP0000685_abnormal_immune_system3.59139605
7MP0005671_abnormal_response_to3.55957564
8MP0005000_abnormal_immune_tolerance3.24018771
9* MP0002452_abnormal_antigen_presenting3.22432114
10* MP0002723_abnormal_immune_serum3.05607541
11* MP0002420_abnormal_adaptive_immunity3.01667213
12MP0003303_peritoneal_inflammation2.97423585
13* MP0001819_abnormal_immune_cell2.96082441
14* MP0002398_abnormal_bone_marrow2.76882459
15MP0004510_myositis2.73215907
16MP0001873_stomach_inflammation2.57993105
17MP0003436_decreased_susceptibility_to2.54888950
18* MP0000716_abnormal_immune_system2.53202323
19MP0005025_abnormal_response_to2.46441539
20MP0003300_gastrointestinal_ulcer2.42917400
21* MP0000689_abnormal_spleen_morphology2.33523439
22MP0002419_abnormal_innate_immunity2.30896126
23MP0002166_altered_tumor_susceptibility2.25520700
24* MP0002405_respiratory_system_inflammati2.24692398
25MP0009785_altered_susceptibility_to2.23824060
26MP0002148_abnormal_hypersensitivity_rea2.22104898
27* MP0002722_abnormal_immune_system2.18975927
28* MP0002429_abnormal_blood_cell2.05414559
29MP0000703_abnormal_thymus_morphology2.04463032
30MP0009333_abnormal_splenocyte_physiolog2.04099354
31MP0002396_abnormal_hematopoietic_system2.03419780
32MP0010155_abnormal_intestine_physiology2.00171536
33MP0003866_abnormal_defecation1.89327364
34MP0006082_CNS_inflammation1.81511775
35MP0002006_tumorigenesis1.79905136
36* MP0001845_abnormal_inflammatory_respons1.79324381
37MP0005464_abnormal_platelet_physiology1.75326383
38MP0001853_heart_inflammation1.70911855
39* MP0004947_skin_inflammation1.67056441
40MP0002933_joint_inflammation1.58977844
41MP0005451_abnormal_body_composition1.57437999
42MP0004808_abnormal_hematopoietic_stem1.56947300
43MP0003183_abnormal_peptide_metabolism1.55356857
44MP0005310_abnormal_salivary_gland1.51455165
45MP0000465_gastrointestinal_hemorrhage1.43089285
46MP0008260_abnormal_autophagy1.36938195
47MP0003724_increased_susceptibility_to1.32244625
48MP0008961_abnormal_basal_metabolism1.27885979
49MP0005076_abnormal_cell_differentiation1.25407718
50MP0010352_gastrointestinal_tract_polyps1.22356108
51MP0009278_abnormal_bone_marrow1.21973403
52MP0005174_abnormal_tail_pigmentation1.18297100
53MP0003448_altered_tumor_morphology1.15451550
54* MP0008469_abnormal_protein_level1.13184349
55MP0000858_altered_metastatic_potential1.11397817
56MP0000490_abnormal_crypts_of1.07997246
57MP0001533_abnormal_skeleton_physiology1.05620487
58MP0001348_abnormal_lacrimal_gland1.05389945
59MP0003191_abnormal_cellular_cholesterol1.03019818
60MP0001545_abnormal_hematopoietic_system1.01776754
61MP0005397_hematopoietic_system_phenotyp1.01776754
62MP0003172_abnormal_lysosome_physiology0.96267872
63MP0002019_abnormal_tumor_incidence0.96129135
64MP0001851_eye_inflammation0.90396346
65MP0002998_abnormal_bone_remodeling0.89632781
66MP0008057_abnormal_DNA_replication0.86246140
67MP0002138_abnormal_hepatobiliary_system0.77547042
68MP0005058_abnormal_lysosome_morphology0.77190924
69MP0003045_fibrosis0.76987933
70MP0004883_abnormal_blood_vessel0.75220763
71MP0002277_abnormal_respiratory_mucosa0.74245370
72MP0002136_abnormal_kidney_physiology0.73563978
73MP0000569_abnormal_digit_pigmentation0.72794615
74MP0002009_preneoplasia0.72172172
75MP0003091_abnormal_cell_migration0.71354248
76MP0001663_abnormal_digestive_system0.71183104
77MP0003566_abnormal_cell_adhesion0.71135142
78MP0003453_abnormal_keratinocyte_physiol0.70382181
79MP0009840_abnormal_foam_cell0.69567736
80MP0003077_abnormal_cell_cycle0.69313437
81MP0004264_abnormal_extraembryonic_tissu0.68589595
82MP0009764_decreased_sensitivity_to0.68506242
83MP0010307_abnormal_tumor_latency0.68067344
84MP0002132_abnormal_respiratory_system0.67300654
85MP0002254_reproductive_system_inflammat0.64616856
86MP0005075_abnormal_melanosome_morpholog0.64532082
87MP0002693_abnormal_pancreas_physiology0.61281422
88MP0001986_abnormal_taste_sensitivity0.59388960
89MP0000015_abnormal_ear_pigmentation0.59114977
90MP0005023_abnormal_wound_healing0.58615843
91MP0002163_abnormal_gland_morphology0.58337141
92MP0009763_increased_sensitivity_to0.58017551
93MP0000609_abnormal_liver_physiology0.56183100
94MP0005166_decreased_susceptibility_to0.54279691
95MP0000249_abnormal_blood_vessel0.52611553
96MP0003795_abnormal_bone_structure0.52291077
97MP0003828_pulmonary_edema0.52193519
98MP0002928_abnormal_bile_duct0.51873603
99MP0005381_digestive/alimentary_phenotyp0.51520612
100MP0000371_diluted_coat_color0.49412813
101MP0004381_abnormal_hair_follicle0.48994866
102MP0005621_abnormal_cell_physiology0.48509218
103MP0000477_abnormal_intestine_morphology0.48123331
104MP0010094_abnormal_chromosome_stability0.47692179
105MP0008874_decreased_physiological_sensi0.47607056
106MP0002095_abnormal_skin_pigmentation0.47222750
107MP0003221_abnormal_cardiomyocyte_apopto0.45724831
108MP0000313_abnormal_cell_death0.45575014
109MP0003690_abnormal_glial_cell0.44503904
110MP0004130_abnormal_muscle_cell0.42752013
111MP0003693_abnormal_embryo_hatching0.42424746
112MP0004185_abnormal_adipocyte_glucose0.42417187
113MP0000604_amyloidosis0.41959559
114MP0005390_skeleton_phenotype0.41881076
115MP0000350_abnormal_cell_proliferation0.41683233

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)5.56174605
2Agammaglobulinemia (HP:0004432)5.50656664
3Recurrent viral infections (HP:0004429)4.98273928
4T lymphocytopenia (HP:0005403)4.97254157
5Panhypogammaglobulinemia (HP:0003139)4.78475705
6Abnormality of T cell number (HP:0011839)4.74366354
7Chronic otitis media (HP:0000389)4.73031055
8Recurrent fungal infections (HP:0002841)4.63176076
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.58268861
10Gastrointestinal stroma tumor (HP:0100723)4.28537686
11Inflammation of the large intestine (HP:0002037)4.28504875
12Colitis (HP:0002583)4.26890356
13Recurrent abscess formation (HP:0002722)4.24303392
14Eczematoid dermatitis (HP:0000976)4.20623949
15Recurrent cutaneous fungal infections (HP:0011370)4.19593521
16Chronic mucocutaneous candidiasis (HP:0002728)4.19593521
17Recurrent sinusitis (HP:0011108)4.18025388
18Gastrointestinal inflammation (HP:0004386)4.14468284
19Cellulitis (HP:0100658)4.04170609
20Abnormality of T cells (HP:0002843)3.99612485
21Meningitis (HP:0001287)3.92656461
22Lymphopenia (HP:0001888)3.85140474
23Nasal polyposis (HP:0100582)3.83999314
24Recurrent bacterial skin infections (HP:0005406)3.74161711
25Verrucae (HP:0200043)3.67966664
26Papilloma (HP:0012740)3.67966664
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.67384422
28Gastrointestinal infarctions (HP:0005244)3.66278385
29Abnormality of the fingertips (HP:0001211)3.63680119
30Vasculitis (HP:0002633)3.58016704
31Elevated erythrocyte sedimentation rate (HP:0003565)3.56839025
32Pustule (HP:0200039)3.52150534
33* IgM deficiency (HP:0002850)3.46522085
34Stomatitis (HP:0010280)3.35009925
35Mediastinal lymphadenopathy (HP:0100721)3.34403534
36Recurrent skin infections (HP:0001581)3.33584084
37Autoimmune thrombocytopenia (HP:0001973)3.26646865
38IgA deficiency (HP:0002720)3.25503432
39Emphysema (HP:0002097)3.22214802
40Chronic sinusitis (HP:0011109)3.21832812
41Thyroiditis (HP:0100646)3.21608839
42Abnormality of the nasal mucosa (HP:0000433)3.19992034
43Combined immunodeficiency (HP:0005387)3.17055801
44IgG deficiency (HP:0004315)3.15107137
45Myositis (HP:0100614)3.13766123
46Bronchitis (HP:0012387)3.08244592
47Abnormality of T cell physiology (HP:0011840)3.05302075
48Autoimmune hemolytic anemia (HP:0001890)3.03532527
49Severe combined immunodeficiency (HP:0004430)3.00522764
50Abnormality of B cell number (HP:0010975)2.97522182
51B lymphocytopenia (HP:0010976)2.97522182
52Chronic diarrhea (HP:0002028)2.97120114
53Increased IgM level (HP:0003496)2.94881192
54Obstructive lung disease (HP:0006536)2.86261476
55Chronic obstructive pulmonary disease (HP:0006510)2.86261476
56Spontaneous hematomas (HP:0007420)2.79423503
57Increased IgE level (HP:0003212)2.78989486
58Restrictive lung disease (HP:0002091)2.74279330
59Encephalitis (HP:0002383)2.69609753
60Recurrent otitis media (HP:0000403)2.69442299
61Eosinophilia (HP:0001880)2.66859244
62Interstitial pulmonary disease (HP:0006530)2.66260517
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65095932
64Osteomyelitis (HP:0002754)2.61607175
65Urticaria (HP:0001025)2.60862583
66Pulmonary infiltrates (HP:0002113)2.55229657
67Recurrent gram-negative bacterial infections (HP:0005420)2.54778286
68Lymphoma (HP:0002665)2.54320709
69Abnormality of eosinophils (HP:0001879)2.53441592
70Leukocytosis (HP:0001974)2.49346830
71Retrobulbar optic neuritis (HP:0100654)2.39366627
72Optic neuritis (HP:0100653)2.39366627
73Recurrent pneumonia (HP:0006532)2.39234178
74Recurrent lower respiratory tract infections (HP:0002783)2.37625125
75Increased density of long bones (HP:0006392)2.35363146
76Hypochromic anemia (HP:0001931)2.33091125
77Granulocytopenia (HP:0001913)2.30900910
78Thrombocytosis (HP:0001894)2.30589828
79Sepsis (HP:0100806)2.27499443
80Prolonged bleeding time (HP:0003010)2.26140657
81Slow saccadic eye movements (HP:0000514)2.25451475
82Gingivitis (HP:0000230)2.25292930
83Periodontitis (HP:0000704)2.24549684
84Keratoconjunctivitis (HP:0001096)2.21565811
85Papilledema (HP:0001085)2.21436259
86Pulmonary embolism (HP:0002204)2.18912186
87Hypoplasia of the thymus (HP:0000778)2.17874676
88Abnormality of macrophages (HP:0004311)2.17322604
89Skin ulcer (HP:0200042)2.17218985
90Orchitis (HP:0100796)2.16970783
91Hemoptysis (HP:0002105)2.15156911
92Abnormal platelet volume (HP:0011876)2.14903987
93Premature loss of primary teeth (HP:0006323)2.14495006
94Arterial thrombosis (HP:0004420)2.10318441
95Viral hepatitis (HP:0006562)2.09926122
96Aplasia/Hypoplasia of the thymus (HP:0010515)2.08251343
97Acute hepatic failure (HP:0006554)2.07226011
98Leukopenia (HP:0001882)2.05418247
99Basal cell carcinoma (HP:0002671)2.05283301
100Skin rash (HP:0000988)2.01009188
101Epistaxis (HP:0000421)2.00235429
102Cheilitis (HP:0100825)2.00126508
103Chest pain (HP:0100749)1.99483601
104Abnormality of the pleura (HP:0002103)1.98694654
105Abnormality of the prostate (HP:0008775)1.98434317
106Vertebral arch anomaly (HP:0008438)1.96525649
107Gingival bleeding (HP:0000225)1.93136686
108Anorexia (HP:0002039)1.92914414
109Petechiae (HP:0000967)1.92889378
110Fatigue (HP:0012378)1.91637838
111Myocardial infarction (HP:0001658)1.90958676
112Joint swelling (HP:0001386)1.88138493
113Arthralgia (HP:0002829)1.87005233
114Hematochezia (HP:0002573)1.83637350
115Hypergammaglobulinemia (HP:0010702)1.79054916
116Hepatitis (HP:0012115)1.76366312
117Acrocyanosis (HP:0001063)1.75228338
118Keratoconjunctivitis sicca (HP:0001097)1.73796142
119Persistence of primary teeth (HP:0006335)1.73213499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* MAP4K15.61073175
2PRPF4B3.71991691
3TXK3.24264702
4STK102.99015469
5GRK62.74616986
6TYK22.65502461
7JAK32.64547996
8BLK2.58415179
9ITK2.46487201
10MAP3K142.29980157
11ZAP702.29909001
12MAP3K102.23982680
13JAK12.22634861
14SYK2.10239433
15MAP3K131.97575216
16BTK1.92675625
17FGFR41.91162666
18CSF1R1.90498831
19SMG11.89741911
20EEF2K1.89174040
21CDK121.80606833
22CSK1.79214827
23LRRK21.77242591
24IKBKE1.72830050
25ERN11.70408251
26TBK11.67615034
27SIK21.65406891
28HCK1.63575443
29KIT1.59580368
30LCK1.57582926
31FGFR31.54319615
32PASK1.50428813
33MARK31.48195587
34MST41.42085617
35TEC1.40933550
36IRAK41.40631894
37IKBKB1.39802526
38IRAK31.38295120
39RIPK41.37075945
40CLK11.33022326
41TGFBR21.28258433
42FES1.26719477
43PIM11.23763135
44TRIB31.23358915
45NLK1.20115619
46PRKCH1.18631457
47PKN21.15198473
48LYN1.13936717
49BMPR21.05386364
50EPHB11.04588860
51RPS6KA40.97062750
52CHUK0.95826513
53CDC42BPA0.94668833
54SIK30.92375173
55JAK20.90297165
56TNK20.89455009
57* PRKCQ0.88292066
58MAP3K10.86919650
59TAOK30.86209110
60BRD40.78100491
61MAP3K110.77064564
62ALK0.77036210
63MAP3K30.72882160
64TTN0.71372992
65HIPK20.67210430
66TAOK20.66575380
67FGR0.65610933
68MAP3K70.65402953
69CDK40.65222316
70EPHA30.64781376
71MAP2K30.63517012
72PDK10.62166237
73PRKD20.60943247
74CAMKK10.60873652
75KSR20.60210133
76MELK0.56658276
77YES10.54224084
78SIK10.53292117
79NME20.52778518
80CDK90.52702317
81PTK60.52698779
82TESK20.52009152
83MAPK70.51288887
84IRAK10.50912984
85PDPK10.47898421
86ABL10.46424861
87IRAK20.44955992
88CDK60.44912063
89NEK20.44515743
90CAMK1G0.44365599
91INSR0.42953003
92RIPK10.42439499
93ICK0.42347707
94STK240.42010688
95CAMK1D0.41319667
96FYN0.40118888
97KDR0.40089058
98MAP3K80.40027762
99RPS6KA60.39911721
100TAOK10.39809266
101MAPK40.37178816
102DMPK0.36978680
103MAPK120.36903543
104PDGFRB0.36467245
105STK40.36255249
106MAP2K20.36252687
107TYRO30.34690199
108MARK20.33580669
109EGFR0.32342854
110MAPKAPK20.31328306
111RPS6KL10.29529622
112RPS6KC10.29529622
113SGK30.29291188
114MATK0.28608236
115BMX0.27218802
116MAPK30.26983179
117RET0.26143299
118MAPK110.26097464
119TRPM70.25739509
120NEK90.25150676
121PRKCD0.21415953
122PRKD10.19776448

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.24193434
2* B cell receptor signaling pathway_Homo sapiens_hsa046623.61582185
3* T cell receptor signaling pathway_Homo sapiens_hsa046602.79052912
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.66644546
5* NF-kappa B signaling pathway_Homo sapiens_hsa040642.60451868
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.55877322
7Osteoclast differentiation_Homo sapiens_hsa043802.52456264
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46208297
9Antigen processing and presentation_Homo sapiens_hsa046122.45258603
10Hematopoietic cell lineage_Homo sapiens_hsa046402.43512911
11Leishmaniasis_Homo sapiens_hsa051402.31214051
12Measles_Homo sapiens_hsa051622.31182935
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98888511
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71424850
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.70880289
16Chemokine signaling pathway_Homo sapiens_hsa040621.58450950
17Viral myocarditis_Homo sapiens_hsa054161.57873086
18Graft-versus-host disease_Homo sapiens_hsa053321.55080442
19Acute myeloid leukemia_Homo sapiens_hsa052211.54584533
20Herpes simplex infection_Homo sapiens_hsa051681.54277760
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52050593
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51429383
23Toxoplasmosis_Homo sapiens_hsa051451.49184466
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.48914272
25Allograft rejection_Homo sapiens_hsa053301.48750792
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46910052
27Tuberculosis_Homo sapiens_hsa051521.43887969
28Hepatitis B_Homo sapiens_hsa051611.37160036
29Shigellosis_Homo sapiens_hsa051311.34401984
30Influenza A_Homo sapiens_hsa051641.33572932
31Apoptosis_Homo sapiens_hsa042101.30727265
32Pancreatic cancer_Homo sapiens_hsa052121.25300098
33Chronic myeloid leukemia_Homo sapiens_hsa052201.23249476
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17352536
35TNF signaling pathway_Homo sapiens_hsa046681.15773105
36Platelet activation_Homo sapiens_hsa046111.14625917
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11483123
38Epstein-Barr virus infection_Homo sapiens_hsa051691.10932618
39Malaria_Homo sapiens_hsa051441.05333223
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00712560
41HTLV-I infection_Homo sapiens_hsa051660.98253545
42Legionellosis_Homo sapiens_hsa051340.98039193
43Staphylococcus aureus infection_Homo sapiens_hsa051500.96016191
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.95908603
45Non-small cell lung cancer_Homo sapiens_hsa052230.95462692
46Autoimmune thyroid disease_Homo sapiens_hsa053200.95245332
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94050705
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92605573
49Colorectal cancer_Homo sapiens_hsa052100.91500939
50VEGF signaling pathway_Homo sapiens_hsa043700.90388960
51Hepatitis C_Homo sapiens_hsa051600.84418628
52Viral carcinogenesis_Homo sapiens_hsa052030.84020822
53Salmonella infection_Homo sapiens_hsa051320.83733096
54Pertussis_Homo sapiens_hsa051330.83419174
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80705340
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79625245
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79042289
58Prolactin signaling pathway_Homo sapiens_hsa049170.78660423
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74331313
60Asthma_Homo sapiens_hsa053100.71878888
61Base excision repair_Homo sapiens_hsa034100.68787879
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67227754
63Other glycan degradation_Homo sapiens_hsa005110.66447957
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66406243
65Notch signaling pathway_Homo sapiens_hsa043300.63570451
66Non-homologous end-joining_Homo sapiens_hsa034500.63261464
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60547502
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59210270
69Phagosome_Homo sapiens_hsa041450.58705016
70Small cell lung cancer_Homo sapiens_hsa052220.58691770
71MAPK signaling pathway_Homo sapiens_hsa040100.57623199
72Inositol phosphate metabolism_Homo sapiens_hsa005620.57037367
73FoxO signaling pathway_Homo sapiens_hsa040680.55779866
74Endocytosis_Homo sapiens_hsa041440.54643489
75Lysosome_Homo sapiens_hsa041420.51306035
76Insulin resistance_Homo sapiens_hsa049310.50480140
77Lysine degradation_Homo sapiens_hsa003100.49846294
78Rheumatoid arthritis_Homo sapiens_hsa053230.49557868
79African trypanosomiasis_Homo sapiens_hsa051430.49510678
80Type I diabetes mellitus_Homo sapiens_hsa049400.48939505
81Thyroid cancer_Homo sapiens_hsa052160.48680151
82mTOR signaling pathway_Homo sapiens_hsa041500.48668542
83Renal cell carcinoma_Homo sapiens_hsa052110.48501008
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.47518861
85ErbB signaling pathway_Homo sapiens_hsa040120.46434921
86GnRH signaling pathway_Homo sapiens_hsa049120.45528883
87Prostate cancer_Homo sapiens_hsa052150.45259320
88Ribosome_Homo sapiens_hsa030100.44663382
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.43818841
90Endometrial cancer_Homo sapiens_hsa052130.42919685
91p53 signaling pathway_Homo sapiens_hsa041150.41570014
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40738681
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40642005
94Mismatch repair_Homo sapiens_hsa034300.38986840
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.38920668
96MicroRNAs in cancer_Homo sapiens_hsa052060.38637360
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38050164
98Glioma_Homo sapiens_hsa052140.37018134
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.36345501
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36117403
101Proteoglycans in cancer_Homo sapiens_hsa052050.35221989
102HIF-1 signaling pathway_Homo sapiens_hsa040660.34729114
103Dorso-ventral axis formation_Homo sapiens_hsa043200.34313927
104DNA replication_Homo sapiens_hsa030300.34238437
105Long-term potentiation_Homo sapiens_hsa047200.32956210
106Choline metabolism in cancer_Homo sapiens_hsa052310.31459506
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.30849875
108Rap1 signaling pathway_Homo sapiens_hsa040150.30539886
109Pathways in cancer_Homo sapiens_hsa052000.30493714
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29779384
111Insulin signaling pathway_Homo sapiens_hsa049100.28740250
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28534759
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27116223
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26404849
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25685889

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