CARD16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.47679451
2immunoglobulin mediated immune response (GO:0016064)5.10830153
3positive regulation of gamma-delta T cell activation (GO:0046645)5.09990854
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03056008
5antigen processing and presentation of endogenous antigen (GO:0019883)4.82904504
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.80277729
7negative regulation of cell killing (GO:0031342)4.63550721
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.63550721
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49564519
10B cell mediated immunity (GO:0019724)4.23346803
11regulation of B cell receptor signaling pathway (GO:0050855)4.15011053
12negative regulation of interleukin-12 production (GO:0032695)4.11819243
13response to peptidoglycan (GO:0032494)4.06568029
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.95382916
15neutrophil activation (GO:0042119)3.93626481
16granulocyte activation (GO:0036230)3.85413182
17positive regulation of mast cell activation (GO:0033005)3.80833203
18positive regulation by symbiont of host defense response (GO:0052509)3.76310449
19modulation by symbiont of host defense response (GO:0052031)3.76310449
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.76310449
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.76310449
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.76310449
23modulation by symbiont of host immune response (GO:0052553)3.76310449
24interferon-gamma-mediated signaling pathway (GO:0060333)3.71782803
25detection of other organism (GO:0098543)3.63144193
26regulation of gamma-delta T cell activation (GO:0046643)3.62085575
27macrophage activation involved in immune response (GO:0002281)3.57767305
28leukocyte aggregation (GO:0070486)3.57666826
29positive regulation of mast cell activation involved in immune response (GO:0033008)3.56257398
30positive regulation of mast cell degranulation (GO:0043306)3.56257398
31detection of bacterium (GO:0016045)3.48782092
32myeloid cell activation involved in immune response (GO:0002275)3.46958322
33regulation of hypersensitivity (GO:0002883)3.45726777
34microglial cell activation (GO:0001774)3.45411044
35regulation of T cell tolerance induction (GO:0002664)3.44701564
36regulation of mast cell degranulation (GO:0043304)3.44506087
37detection of molecule of bacterial origin (GO:0032490)3.43315158
38T cell migration (GO:0072678)3.42929666
39regulation of regulatory T cell differentiation (GO:0045589)3.41043915
40cellular response to type I interferon (GO:0071357)3.40587332
41type I interferon signaling pathway (GO:0060337)3.40587332
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39119849
43mast cell activation (GO:0045576)3.39103643
44response to type I interferon (GO:0034340)3.36595354
45detection of external biotic stimulus (GO:0098581)3.32322526
46regulation of tolerance induction (GO:0002643)3.30718003
47antigen processing and presentation via MHC class Ib (GO:0002475)3.29086190
48positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.28784163
49regulation of mast cell activation (GO:0033003)3.28337517
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23229869
51positive regulation of B cell differentiation (GO:0045579)3.20975209
52cellular extravasation (GO:0045123)3.20077843
53regulation of antigen processing and presentation (GO:0002577)3.19464811
54positive regulation of interleukin-1 beta secretion (GO:0050718)3.19149300
55regulation of alpha-beta T cell proliferation (GO:0046640)3.19034734
56cytidine metabolic process (GO:0046087)3.16939734
57cytidine catabolic process (GO:0006216)3.16939734
58cytidine deamination (GO:0009972)3.16939734
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16270497
60regulation of mast cell activation involved in immune response (GO:0033006)3.16190395
61regulation of gamma-delta T cell differentiation (GO:0045586)3.16126577
62positive thymic T cell selection (GO:0045059)3.15846184
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15668500
64respiratory burst (GO:0045730)3.15478195
65lymphocyte chemotaxis (GO:0048247)3.14110961
66defense response to protozoan (GO:0042832)3.10389636
67positive regulation of B cell mediated immunity (GO:0002714)3.02731561
68positive regulation of immunoglobulin mediated immune response (GO:0002891)3.02731561
69positive regulation of antigen processing and presentation (GO:0002579)3.02465342
70positive regulation of type 2 immune response (GO:0002830)3.01819296
71regulation of interleukin-1 beta secretion (GO:0050706)3.00741434
72positive regulation of interleukin-1 secretion (GO:0050716)3.00177692
73regulation of T-helper 1 cell differentiation (GO:0045625)2.98901069
74cellular response to interferon-gamma (GO:0071346)2.98269607
75positive regulation of monocyte chemotaxis (GO:0090026)2.98264152
76detection of biotic stimulus (GO:0009595)2.97978128
77positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97620542
78negative regulation of T cell mediated immunity (GO:0002710)2.96861833
79regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96097266
80regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95557908
81response to interferon-beta (GO:0035456)2.94967220
82regulation of natural killer cell mediated immunity (GO:0002715)2.94825616
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94825616
84macrophage activation (GO:0042116)2.93423511
85positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93217081
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.90539927
87negative T cell selection (GO:0043383)2.90389339
88T cell costimulation (GO:0031295)2.90117009
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88776279
90negative regulation of leukocyte mediated immunity (GO:0002704)2.88030472
91regulation of T cell mediated cytotoxicity (GO:0001914)2.87902466
92lymphocyte costimulation (GO:0031294)2.86367368
93regulation of B cell differentiation (GO:0045577)2.86354365
94positive regulation of interleukin-17 production (GO:0032740)2.86026026
95response to interleukin-15 (GO:0070672)2.84683528
96response to interferon-gamma (GO:0034341)2.84485142
97response to protozoan (GO:0001562)2.83441304
98positive regulation of tolerance induction (GO:0002645)2.82841656
99negative regulation of cytokine production involved in immune response (GO:0002719)2.82603193
100negative thymic T cell selection (GO:0045060)2.82182015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.59448009
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.92964191
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.28400085
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.41289277
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.14006029
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90922683
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.77928182
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34781198
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.27630959
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05654758
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.77604898
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75006823
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69103422
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68168511
15RUNX_20019798_ChIP-Seq_JUKART_Human2.66029315
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65027768
17MYB_26560356_Chip-Seq_TH2_Human2.55616913
18SPI1_23547873_ChIP-Seq_NB4_Human2.55023059
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49510798
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37650103
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34346423
22SCL_19346495_ChIP-Seq_HPC-7_Human2.23399578
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14527157
24SPI1_23127762_ChIP-Seq_K562_Human2.12829537
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11800595
26VDR_24763502_ChIP-Seq_THP-1_Human1.98060795
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94301995
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91320250
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91283858
30MYB_26560356_Chip-Seq_TH1_Human1.89364006
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87133813
32MAF_26560356_Chip-Seq_TH1_Human1.85813334
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.85718423
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82915019
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80668442
36GATA3_27048872_Chip-Seq_THYMUS_Human1.79877486
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78043622
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77542700
39UTX_26944678_Chip-Seq_JUKART_Human1.77159310
40GATA3_26560356_Chip-Seq_TH2_Human1.76288432
41VDR_24787735_ChIP-Seq_THP-1_Human1.71582724
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67121893
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.62369034
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59852073
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.52472387
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48946547
47VDR_21846776_ChIP-Seq_THP-1_Human1.44246292
48MAF_26560356_Chip-Seq_TH2_Human1.30653331
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29693067
50SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29509534
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29255428
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27573152
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26870055
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.25412052
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25140461
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23294761
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22348686
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16658338
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15982946
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14758291
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11819763
62BCL6_27268052_Chip-Seq_Bcells_Human1.11654455
63PU_27001747_Chip-Seq_BMDM_Mouse1.11423042
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.09793375
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06386750
66STAT1_20625510_ChIP-Seq_HELA_Human1.04822804
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04520826
68GATA1_19941826_ChIP-Seq_K562_Human0.99625509
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99248865
70GATA1_22025678_ChIP-Seq_K562_Human0.99002524
71GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98418726
72IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92280351
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91185318
74PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89964862
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89926261
76SPI1_20517297_ChIP-Seq_HL60_Human0.89387131
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89380462
78EGR1_19374776_ChIP-ChIP_THP-1_Human0.87466270
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85979695
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85958918
81BCOR_27268052_Chip-Seq_Bcells_Human0.83916560
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79971993
83P300_27268052_Chip-Seq_Bcells_Human0.79282877
84GATA2_19941826_ChIP-Seq_K562_Human0.77138247
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.75902526
86MYC_22102868_ChIP-Seq_BL_Human0.74909900
87TCF7_22412390_ChIP-Seq_EML_Mouse0.74519791
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.74480768
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74438317
90SMRT_27268052_Chip-Seq_Bcells_Human0.74398202
91EGR1_19032775_ChIP-ChIP_M12_Human0.73577968
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72709699
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70429519
94GATA3_26560356_Chip-Seq_TH1_Human0.66638936
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66033384
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.64674159
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64113074
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.64057119
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61872678
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.61809998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.86059254
2MP0003724_increased_susceptibility_to4.20761616
3MP0005671_abnormal_response_to4.12201101
4MP0009785_altered_susceptibility_to3.51843332
5MP0003436_decreased_susceptibility_to3.40940152
6MP0002148_abnormal_hypersensitivity_rea3.26032255
7MP0003303_peritoneal_inflammation3.24307590
8MP0005000_abnormal_immune_tolerance3.22537042
9MP0006082_CNS_inflammation3.18623852
10MP0001800_abnormal_humoral_immune3.00303442
11MP0005025_abnormal_response_to2.98038126
12MP0002419_abnormal_innate_immunity2.91248535
13MP0001790_abnormal_immune_system2.85721298
14MP0005387_immune_system_phenotype2.85721298
15MP0002723_abnormal_immune_serum2.73476884
16MP0002452_abnormal_antigen_presenting2.68283331
17MP0000685_abnormal_immune_system2.66713669
18MP0005464_abnormal_platelet_physiology2.55603645
19MP0002420_abnormal_adaptive_immunity2.50995752
20MP0001819_abnormal_immune_cell2.48586773
21MP0010155_abnormal_intestine_physiology2.21522731
22MP0009764_decreased_sensitivity_to2.15228111
23MP0001845_abnormal_inflammatory_respons1.98551554
24MP0003763_abnormal_thymus_physiology1.98286722
25MP0009333_abnormal_splenocyte_physiolog1.96243819
26MP0001533_abnormal_skeleton_physiology1.91356614
27MP0003806_abnormal_nucleotide_metabolis1.88566859
28MP0000716_abnormal_immune_system1.85545074
29MP0002405_respiratory_system_inflammati1.85123332
30MP0002398_abnormal_bone_marrow1.79352580
31MP0003075_altered_response_to1.76558276
32MP0004947_skin_inflammation1.76087926
33MP0003300_gastrointestinal_ulcer1.74411672
34MP0005058_abnormal_lysosome_morphology1.72201379
35MP0000858_altered_metastatic_potential1.62717630
36MP0008469_abnormal_protein_level1.62089064
37MP0003866_abnormal_defecation1.54919842
38MP0000465_gastrointestinal_hemorrhage1.53052557
39MP0000343_altered_response_to1.51305602
40MP0000689_abnormal_spleen_morphology1.47951935
41MP0002166_altered_tumor_susceptibility1.46999893
42MP0001853_heart_inflammation1.46608693
43MP0002429_abnormal_blood_cell1.45308337
44MP0005166_decreased_susceptibility_to1.43626870
45MP0002722_abnormal_immune_system1.41215306
46MP0001873_stomach_inflammation1.39833488
47MP0003448_altered_tumor_morphology1.38211345
48MP0008004_abnormal_stomach_pH1.33416648
49MP0005310_abnormal_salivary_gland1.33303216
50MP0003172_abnormal_lysosome_physiology1.31869535
51MP0004510_myositis1.30895161
52MP0002998_abnormal_bone_remodeling1.27800065
53MP0003191_abnormal_cellular_cholesterol1.26803448
54MP0009278_abnormal_bone_marrow1.23790463
55MP0005397_hematopoietic_system_phenotyp1.16382706
56MP0001545_abnormal_hematopoietic_system1.16382706
57MP0002138_abnormal_hepatobiliary_system1.14877851
58MP0009763_increased_sensitivity_to1.14621308
59MP0002006_tumorigenesis1.10757691
60MP0006054_spinal_hemorrhage1.08125399
61MP0001663_abnormal_digestive_system1.02890093
62MP0000703_abnormal_thymus_morphology1.02720587
63MP0003828_pulmonary_edema0.98471767
64MP0002277_abnormal_respiratory_mucosa0.96270911
65MP0003183_abnormal_peptide_metabolism0.93991944
66MP0000604_amyloidosis0.93095596
67MP0002132_abnormal_respiratory_system0.92663343
68MP0004883_abnormal_blood_vessel0.89138908
69MP0008260_abnormal_autophagy0.89090621
70MP0005164_abnormal_response_to0.88027955
71MP0009840_abnormal_foam_cell0.84123263
72MP0002933_joint_inflammation0.81572691
73MP0001851_eye_inflammation0.80772488
74MP0003656_abnormal_erythrocyte_physiolo0.79304476
75MP0005390_skeleton_phenotype0.77995053
76MP0000249_abnormal_blood_vessel0.76379424
77MP0005167_abnormal_blood-brain_barrier0.73124654
78MP0005075_abnormal_melanosome_morpholog0.72801436
79MP0003690_abnormal_glial_cell0.72437836
80MP0005451_abnormal_body_composition0.72274228
81MP0009765_abnormal_xenobiotic_induced0.72254730
82MP0004381_abnormal_hair_follicle0.71834803
83MP0003045_fibrosis0.68616316
84MP0001542_abnormal_bone_strength0.68147634
85MP0003795_abnormal_bone_structure0.64628005
86MP0000490_abnormal_crypts_of0.62015154
87MP0000920_abnormal_myelination0.61964506
88MP0005165_increased_susceptibility_to0.59826058
89MP0008874_decreased_physiological_sensi0.59179623
90MP0002139_abnormal_hepatobiliary_system0.57960311
91MP0005381_digestive/alimentary_phenotyp0.57779020
92MP0002332_abnormal_exercise_endurance0.55799107
93MP0005319_abnormal_enzyme/_coenzyme0.54523087
94MP0002136_abnormal_kidney_physiology0.53312054
95MP0005584_abnormal_enzyme/coenzyme_acti0.52905006
96MP0002693_abnormal_pancreas_physiology0.52779605
97MP0000015_abnormal_ear_pigmentation0.51209727
98MP0000569_abnormal_digit_pigmentation0.51035653
99MP0002019_abnormal_tumor_incidence0.49103931
100MP0005535_abnormal_body_temperature0.48659829

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.24396632
2Recurrent abscess formation (HP:0002722)5.08888497
3Abnormality of macrophages (HP:0004311)5.01661989
4Elevated erythrocyte sedimentation rate (HP:0003565)4.92412487
5Myositis (HP:0100614)4.79033192
6Eczematoid dermatitis (HP:0000976)4.70021760
7Stomatitis (HP:0010280)4.67142939
8Optic neuritis (HP:0100653)4.34440653
9Retrobulbar optic neuritis (HP:0100654)4.34440653
10Orchitis (HP:0100796)4.30638147
11Obstructive lung disease (HP:0006536)3.93129175
12Chronic obstructive pulmonary disease (HP:0006510)3.93129175
13T lymphocytopenia (HP:0005403)3.93101593
14Abnormality of T cell number (HP:0011839)3.92439042
15Increased IgM level (HP:0003496)3.70348399
16Mediastinal lymphadenopathy (HP:0100721)3.66932861
17Meningitis (HP:0001287)3.63101381
18Recurrent gram-negative bacterial infections (HP:0005420)3.59344185
19Recurrent fungal infections (HP:0002841)3.55383343
20Recurrent skin infections (HP:0001581)3.50643491
21Vasculitis (HP:0002633)3.49415652
22Pulmonary infiltrates (HP:0002113)3.40160443
23Gastrointestinal infarctions (HP:0005244)3.39173432
24Encephalitis (HP:0002383)3.37417768
25Petechiae (HP:0000967)3.35062879
26Chronic otitis media (HP:0000389)3.31549878
27Autoimmune hemolytic anemia (HP:0001890)3.31325886
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.28069785
29Abnormality of glycolipid metabolism (HP:0010969)3.28069785
30Abnormality of liposaccharide metabolism (HP:0010968)3.28069785
31Autoimmune thrombocytopenia (HP:0001973)3.27123371
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.25294566
33Hemoptysis (HP:0002105)3.17619132
34Keratoconjunctivitis sicca (HP:0001097)3.13937196
35Purpura (HP:0000979)3.12772751
36Chronic mucocutaneous candidiasis (HP:0002728)3.10919849
37Recurrent cutaneous fungal infections (HP:0011370)3.10919849
38Prolonged bleeding time (HP:0003010)3.08974108
39Recurrent bronchitis (HP:0002837)3.02392859
40Epistaxis (HP:0000421)3.02192427
41Spontaneous hematomas (HP:0007420)3.01327922
42Abnormality of T cells (HP:0002843)2.97803174
43Gangrene (HP:0100758)2.94611532
44Systemic lupus erythematosus (HP:0002725)2.91553547
45Keratoconjunctivitis (HP:0001096)2.91193541
46Leukocytosis (HP:0001974)2.89839920
47Urticaria (HP:0001025)2.88577679
48Chest pain (HP:0100749)2.87284199
49Gingival bleeding (HP:0000225)2.82211622
50Pustule (HP:0200039)2.80070301
51IgG deficiency (HP:0004315)2.79013558
52Recurrent viral infections (HP:0004429)2.78028046
53Increased cerebral lipofuscin (HP:0011813)2.77405373
54Hypergammaglobulinemia (HP:0010702)2.66745454
55Arterial thrombosis (HP:0004420)2.64515789
56Eosinophilia (HP:0001880)2.61121743
57Gingivitis (HP:0000230)2.60666586
58Nasal polyposis (HP:0100582)2.58134601
59Pulmonary embolism (HP:0002204)2.58002888
60Abnormality of the prostate (HP:0008775)2.57581663
61Joint swelling (HP:0001386)2.56014071
62Granulocytopenia (HP:0001913)2.52137681
63Abnormality of the nasal mucosa (HP:0000433)2.51270376
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.50477681
65Amyloidosis (HP:0011034)2.49981725
66Anorexia (HP:0002039)2.48910245
67Chronic diarrhea (HP:0002028)2.44841295
68Abnormality of B cell number (HP:0010975)2.43776418
69Abnormality of the pleura (HP:0002103)2.43036210
70Agammaglobulinemia (HP:0004432)2.41747634
71Increased serum ferritin (HP:0003281)2.40454770
72Increased IgE level (HP:0003212)2.39440063
73Abnormality of eosinophils (HP:0001879)2.38375289
74Vacuolated lymphocytes (HP:0001922)2.38025515
75Polyneuropathy (HP:0001271)2.34861367
76Chronic sinusitis (HP:0011109)2.28598384
77Dysostosis multiplex (HP:0000943)2.23959322
78Glomerulopathy (HP:0100820)2.20890993
79Abnormality of T cell physiology (HP:0011840)2.17825029
80Abnormality of iron homeostasis (HP:0011031)2.17659223
81Panhypogammaglobulinemia (HP:0003139)2.16895248
82Loss of speech (HP:0002371)2.16612010
83Inflammation of the large intestine (HP:0002037)2.15812945
84Vertigo (HP:0002321)2.13157086
85Episodic fever (HP:0001954)2.12734197
86Basal ganglia calcification (HP:0002135)2.11948121
87Severe combined immunodeficiency (HP:0004430)2.07193660
88Skin rash (HP:0000988)2.07089966
89Hypoproteinemia (HP:0003075)2.06970021
90Lymphopenia (HP:0001888)2.05356121
91B lymphocytopenia (HP:0010976)2.03702048
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.03302095
93Disinhibition (HP:0000734)2.00793707
94Hepatosplenomegaly (HP:0001433)2.00676596
95Arthralgia (HP:0002829)2.00354870
96Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98285254
97Alveolar cell carcinoma (HP:0006519)1.96717298
98Gastrointestinal inflammation (HP:0004386)1.96633409
99Premature loss of primary teeth (HP:0006323)1.95656605
100IgM deficiency (HP:0002850)1.94679845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.20585321
2RIPK44.06820127
3MAP4K13.56594659
4BMPR23.19410890
5TAOK32.97689336
6BLK2.96143337
7MAP3K132.52620215
8MAP3K142.37639588
9TYK22.34198678
10CSK2.32817321
11FES2.26725137
12ZAP702.17971407
13BTK2.11131956
14IRAK42.08649027
15SYK2.07926887
16JAK32.02367569
17TBK11.93797932
18IKBKE1.92291930
19GRK61.90256691
20IKBKB1.87580586
21TESK21.84331690
22CSF1R1.81823894
23GRK71.77459359
24TLK11.76275957
25LYN1.74818402
26KDR1.74476167
27MAP3K121.67628624
28MAP2K31.65013697
29KIT1.61262539
30TNK21.57103655
31TEC1.55669372
32ITK1.53324439
33FGR1.50507532
34HCK1.47960476
35MAP3K111.46647203
36LCK1.41110460
37MATK1.39660043
38JAK11.35432332
39PIK3CG1.25221864
40IRAK31.18986864
41MAP3K31.18807793
42TAOK21.18675006
43ERN11.11279358
44JAK21.11073830
45TGFBR21.03655918
46ADRBK21.01003087
47MYLK0.98697970
48MARK30.84652853
49MOS0.82493608
50TAOK10.82318072
51MAP3K10.81110340
52CDK190.71832432
53SIK30.70947860
54TESK10.69776994
55PRPF4B0.67284669
56PIM10.67250293
57IRAK10.66882661
58MST40.65869158
59ARAF0.65757185
60MAP3K50.64846532
61ACVR1B0.63596878
62PRKCQ0.63024092
63FYN0.62529458
64ILK0.58497542
65PDK10.57585571
66CHUK0.54107826
67MAP2K60.52472105
68NME20.52258535
69CAMKK20.47469278
70GRK50.45994077
71STK100.45096305
72PIM20.44940256
73BCKDK0.44150646
74ABL10.42483652
75IGF1R0.40311384
76DAPK30.39344143
77IRAK20.36124231
78PRKCD0.36094839
79DAPK10.33910900
80PDPK10.33865150
81PTK2B0.33501111
82EPHB10.33458697
83EGFR0.31959887
84MAPK70.30646598
85DAPK20.29592963
86ABL20.29543731
87MAPKAPK20.28679707
88CDC42BPA0.28613474
89BMX0.28602272
90TRPM70.27804019
91PAK10.27154755
92LRRK20.25584352
93CLK10.20722070
94MAPK120.20651495
95ADRBK10.20064560
96SCYL20.19779066
97INSR0.19773537
98DYRK1B0.18712347
99MAP4K20.17810365
100HIPK20.17393176

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.90154516
2Graft-versus-host disease_Homo sapiens_hsa053323.89795183
3Asthma_Homo sapiens_hsa053103.70142467
4Autoimmune thyroid disease_Homo sapiens_hsa053203.64151510
5Staphylococcus aureus infection_Homo sapiens_hsa051503.17714883
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.96472145
7Type I diabetes mellitus_Homo sapiens_hsa049402.96303779
8Leishmaniasis_Homo sapiens_hsa051402.92123334
9Antigen processing and presentation_Homo sapiens_hsa046122.78419492
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67073917
11Primary immunodeficiency_Homo sapiens_hsa053402.61028718
12Rheumatoid arthritis_Homo sapiens_hsa053232.34869140
13Osteoclast differentiation_Homo sapiens_hsa043802.25580087
14Hematopoietic cell lineage_Homo sapiens_hsa046402.14186239
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08586615
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07568742
17Viral myocarditis_Homo sapiens_hsa054162.07188244
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01511015
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.91962557
20Tuberculosis_Homo sapiens_hsa051521.89557060
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86939034
22Malaria_Homo sapiens_hsa051441.75523333
23Legionellosis_Homo sapiens_hsa051341.60746097
24Toxoplasmosis_Homo sapiens_hsa051451.48896947
25Influenza A_Homo sapiens_hsa051641.47522871
26T cell receptor signaling pathway_Homo sapiens_hsa046601.45796871
27Measles_Homo sapiens_hsa051621.44239978
28B cell receptor signaling pathway_Homo sapiens_hsa046621.42814271
29Pertussis_Homo sapiens_hsa051331.42424313
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38529534
31Phagosome_Homo sapiens_hsa041451.31209262
32Salmonella infection_Homo sapiens_hsa051321.29693967
33Herpes simplex infection_Homo sapiens_hsa051681.29033273
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25475152
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24480208
36Chemokine signaling pathway_Homo sapiens_hsa040621.22115197
37TNF signaling pathway_Homo sapiens_hsa046681.21509237
38African trypanosomiasis_Homo sapiens_hsa051431.20618863
39Lysosome_Homo sapiens_hsa041421.09471958
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09456474
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09059466
42Shigellosis_Homo sapiens_hsa051311.04588743
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.97832387
44Other glycan degradation_Homo sapiens_hsa005110.96913575
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96114548
46Platelet activation_Homo sapiens_hsa046110.94404576
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91629488
48Systemic lupus erythematosus_Homo sapiens_hsa053220.81059645
49Apoptosis_Homo sapiens_hsa042100.72807574
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.68238636
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.64826697
52Collecting duct acid secretion_Homo sapiens_hsa049660.64079636
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61024765
54Epstein-Barr virus infection_Homo sapiens_hsa051690.60153311
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59965369
56Hepatitis B_Homo sapiens_hsa051610.57978047
57Hepatitis C_Homo sapiens_hsa051600.57724043
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53470812
59Acute myeloid leukemia_Homo sapiens_hsa052210.52867562
60Proteasome_Homo sapiens_hsa030500.52659494
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50865958
62Arachidonic acid metabolism_Homo sapiens_hsa005900.49826429
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49067757
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48348857
65Oxidative phosphorylation_Homo sapiens_hsa001900.44406227
66HTLV-I infection_Homo sapiens_hsa051660.40899514
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39714700
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38550134
69Regulation of autophagy_Homo sapiens_hsa041400.34388337
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.34150133
71Complement and coagulation cascades_Homo sapiens_hsa046100.32845140
72Endocytosis_Homo sapiens_hsa041440.32176510
73Amoebiasis_Homo sapiens_hsa051460.31649831
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.31318604
75Parkinsons disease_Homo sapiens_hsa050120.30088198
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29406184
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26302714
78Linoleic acid metabolism_Homo sapiens_hsa005910.21165397
79VEGF signaling pathway_Homo sapiens_hsa043700.18993957
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.17309466
81Prion diseases_Homo sapiens_hsa050200.17048842
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16927008
83Pancreatic cancer_Homo sapiens_hsa052120.16396879
84Bladder cancer_Homo sapiens_hsa052190.15776226
85Sulfur metabolism_Homo sapiens_hsa009200.13860236
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13504746
87Viral carcinogenesis_Homo sapiens_hsa052030.13202990
88Alzheimers disease_Homo sapiens_hsa050100.12503350
89Renin-angiotensin system_Homo sapiens_hsa046140.10761289
90Prolactin signaling pathway_Homo sapiens_hsa049170.10528898
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10099056
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09911215
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09768503
94Non-small cell lung cancer_Homo sapiens_hsa052230.08038945
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07397914
96Mineral absorption_Homo sapiens_hsa049780.07196370
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.06753970
98HIF-1 signaling pathway_Homo sapiens_hsa040660.04384766
99MAPK signaling pathway_Homo sapiens_hsa040100.04106892
100Ether lipid metabolism_Homo sapiens_hsa005650.03375474

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