CARD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.87476828
2antigen processing and presentation of endogenous antigen (GO:0019883)5.52702151
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.48265277
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.48265277
5regulation of gamma-delta T cell differentiation (GO:0045586)5.17539793
6neutrophil activation involved in immune response (GO:0002283)5.01924174
7positive thymic T cell selection (GO:0045059)4.93121119
8regulation of gamma-delta T cell activation (GO:0046643)4.72257440
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63600609
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.63600609
11modulation by symbiont of host immune response (GO:0052553)4.63600609
12positive regulation by symbiont of host defense response (GO:0052509)4.63600609
13modulation by symbiont of host defense response (GO:0052031)4.63600609
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63600609
15regulation of B cell receptor signaling pathway (GO:0050855)4.62875746
16negative regulation of interleukin-12 production (GO:0032695)4.57567376
17negative T cell selection (GO:0043383)4.48159493
18negative thymic T cell selection (GO:0045060)4.42293955
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.40188724
20response to peptidoglycan (GO:0032494)4.30449849
21negative regulation of cell killing (GO:0031342)4.25388190
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.25388190
23response to interleukin-15 (GO:0070672)4.21299930
24B cell receptor signaling pathway (GO:0050853)4.20671462
25detection of molecule of bacterial origin (GO:0032490)4.18541183
26thymic T cell selection (GO:0045061)4.16037907
27interferon-gamma production (GO:0032609)4.11421550
28positive T cell selection (GO:0043368)4.09317369
29T cell selection (GO:0045058)3.90731196
30microglial cell activation (GO:0001774)3.90017359
31regulation of B cell differentiation (GO:0045577)3.87421722
32cellular response to interleukin-15 (GO:0071350)3.85508124
33neutrophil activation (GO:0042119)3.81845969
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80461869
35macrophage activation (GO:0042116)3.79522305
36detection of other organism (GO:0098543)3.76299369
37regulation of T cell tolerance induction (GO:0002664)3.61202041
38granulocyte activation (GO:0036230)3.60545657
39positive regulation of B cell differentiation (GO:0045579)3.59419055
40detection of external biotic stimulus (GO:0098581)3.58672846
41tolerance induction (GO:0002507)3.53779723
42leukocyte aggregation (GO:0070486)3.51604603
43myeloid cell activation involved in immune response (GO:0002275)3.50711725
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.47383873
45regulation of mast cell activation (GO:0033003)3.46535241
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44802351
47immunoglobulin mediated immune response (GO:0016064)3.39268141
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34087330
49indolalkylamine catabolic process (GO:0046218)3.32427089
50tryptophan catabolic process (GO:0006569)3.32427089
51indole-containing compound catabolic process (GO:0042436)3.32427089
52antigen receptor-mediated signaling pathway (GO:0050851)3.29542346
53response to host immune response (GO:0052572)3.29107584
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29107584
55detection of bacterium (GO:0016045)3.29033614
56type I interferon signaling pathway (GO:0060337)3.29005089
57cellular response to type I interferon (GO:0071357)3.29005089
58positive regulation of mast cell activation (GO:0033005)3.28036047
59response to type I interferon (GO:0034340)3.27449447
60leukocyte degranulation (GO:0043299)3.26914130
61T cell migration (GO:0072678)3.25836054
62T cell costimulation (GO:0031295)3.25505646
63aromatic amino acid family catabolic process (GO:0009074)3.23858281
64regulation of interferon-beta biosynthetic process (GO:0045357)3.22802104
65negative regulation of T cell mediated immunity (GO:0002710)3.22081526
66lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20900188
67tryptophan metabolic process (GO:0006568)3.19344921
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.17248057
69L-phenylalanine catabolic process (GO:0006559)3.17248057
70lymphocyte costimulation (GO:0031294)3.16708382
71regulation of mast cell degranulation (GO:0043304)3.15926926
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15012478
73negative regulation of lymphocyte mediated immunity (GO:0002707)3.13981901
74production of molecular mediator involved in inflammatory response (GO:0002532)3.12045856
75leukocyte migration involved in inflammatory response (GO:0002523)3.11995553
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10870442
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08523843
78detection of biotic stimulus (GO:0009595)3.08216884
79kynurenine metabolic process (GO:0070189)3.08020869
80T cell receptor signaling pathway (GO:0050852)3.07466986
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06799693
82regulation of alpha-beta T cell proliferation (GO:0046640)3.04288520
83L-phenylalanine metabolic process (GO:0006558)3.03925174
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03925174
85regulation of mast cell activation involved in immune response (GO:0033006)3.02634353
86positive regulation of monocyte chemotaxis (GO:0090026)3.02461011
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01154334
88positive regulation of humoral immune response (GO:0002922)2.98451878
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96380865
90response to host (GO:0075136)2.96380865
91response to host defenses (GO:0052200)2.96380865
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.96203019
93urea cycle (GO:0000050)2.94176151
94urea metabolic process (GO:0019627)2.94176151
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93887340
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93692835
97regulation of response to interferon-gamma (GO:0060330)2.93379217
98interferon-gamma-mediated signaling pathway (GO:0060333)2.93218264
99natural killer cell activation involved in immune response (GO:0002323)2.92992771
100neutrophil mediated immunity (GO:0002446)2.91546620
101regulation of T cell mediated cytotoxicity (GO:0001914)2.90394793
102positive regulation of interleukin-1 beta secretion (GO:0050718)2.90279632
103positive regulation of mast cell activation involved in immune response (GO:0033008)2.89878208
104positive regulation of mast cell degranulation (GO:0043306)2.89878208
105respiratory burst (GO:0045730)2.88802538
106regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.87845065
107negative regulation of leukocyte mediated immunity (GO:0002704)2.86654087
108positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86526034
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85606133
110negative regulation of interleukin-6 production (GO:0032715)2.82557016
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81751657
112positive regulation of interleukin-2 production (GO:0032743)2.81529417
113myeloid leukocyte activation (GO:0002274)2.80923599
114superoxide anion generation (GO:0042554)2.80791871
115mature B cell differentiation (GO:0002335)2.80202675
116regulation of isotype switching to IgG isotypes (GO:0048302)2.79904509
117cellular extravasation (GO:0045123)2.78809854
118cellular response to zinc ion (GO:0071294)2.77367475
119positive regulation of interleukin-1 secretion (GO:0050716)2.76069838
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.75677848
121regulation of antigen processing and presentation (GO:0002577)2.75118479
122T-helper 1 type immune response (GO:0042088)2.74807090
123regulation of superoxide anion generation (GO:0032928)2.73173520
124defense response to protozoan (GO:0042832)2.73124722
125germinal center formation (GO:0002467)2.71728793
126complement activation, classical pathway (GO:0006958)2.71196465
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71157560
128negative regulation of cytokine production involved in immune response (GO:0002719)2.70217908
129negative regulation of interleukin-17 production (GO:0032700)2.69635699
130negative regulation of fibrinolysis (GO:0051918)2.69099811
131complement activation, alternative pathway (GO:0006957)2.68296773
132positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.67622290
133positive regulation of histone deacetylation (GO:0031065)2.67348551
134cytoplasmic mRNA processing body assembly (GO:0033962)2.66297682
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65328516
136positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65056398
137regulation of leukocyte degranulation (GO:0043300)2.65040278
138positive regulation of tolerance induction (GO:0002645)2.64838614
139dendritic cell migration (GO:0036336)2.64627771
140negative regulation of interleukin-1 production (GO:0032692)2.63109632
141regulation of interleukin-1 beta secretion (GO:0050706)2.62825249
142phospholipid efflux (GO:0033700)2.62330846
143positive regulation of interferon-alpha production (GO:0032727)2.61902674
144neutrophil chemotaxis (GO:0030593)2.61597772
145leukocyte cell-cell adhesion (GO:0007159)2.61541460
146response to protozoan (GO:0001562)2.61010390
147negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.60992670
148response to muramyl dipeptide (GO:0032495)2.60818575
149regulation of triglyceride catabolic process (GO:0010896)2.60159449
150regulation of B cell proliferation (GO:0030888)2.59973651
151negative regulation of T-helper cell differentiation (GO:0045623)2.59850804
152negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59850804
153alpha-linolenic acid metabolic process (GO:0036109)2.59381562
154nitrogen cycle metabolic process (GO:0071941)2.58428533
155regulation of protein activation cascade (GO:2000257)2.56645644
156regulation of extracellular matrix disassembly (GO:0010715)2.55329997
157antigen processing and presentation via MHC class Ib (GO:0002475)2.54696558
158positive regulation of immunoglobulin production (GO:0002639)2.54416555
159positive regulation of lipoprotein lipase activity (GO:0051006)2.54026342
160positive regulation of triglyceride lipase activity (GO:0061365)2.54026342
161macrophage activation involved in immune response (GO:0002281)2.52686392
162regulation of interleukin-2 biosynthetic process (GO:0045076)2.50931221
163activated T cell proliferation (GO:0050798)2.50787269
164regulation of tolerance induction (GO:0002643)2.50085141
165bile acid biosynthetic process (GO:0006699)2.49880488
166positive regulation of isotype switching (GO:0045830)2.49735503
167negative regulation of cholesterol transport (GO:0032375)2.49580119
168negative regulation of sterol transport (GO:0032372)2.49580119
169B cell proliferation (GO:0042100)2.49409789
170regulation of humoral immune response (GO:0002920)2.49378836
171regulation of cholesterol homeostasis (GO:2000188)2.49051456
172regulation of interferon-alpha production (GO:0032647)2.48631208
173immune response-activating cell surface receptor signaling pathway (GO:0002429)2.48488462
174complement activation (GO:0006956)2.47899205
175lymphocyte homeostasis (GO:0002260)2.47774714
176G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.47480589
177regulation of T cell receptor signaling pathway (GO:0050856)2.46479759
178regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44285943
179regulation of fibrinolysis (GO:0051917)2.44141154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.32042584
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.04145069
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.44648994
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.05835835
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29010864
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25853276
7MYC_22102868_ChIP-Seq_BL_Human3.14903830
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.14722337
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.11297747
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98362702
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.82428600
12RUNX_20019798_ChIP-Seq_JUKART_Human2.80837131
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74814680
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74174402
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.72515696
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.65868810
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.61190720
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58642782
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57145751
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52242502
21MYB_26560356_Chip-Seq_TH2_Human2.50170136
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45476566
23MYB_26560356_Chip-Seq_TH1_Human2.39663703
24MAF_26560356_Chip-Seq_TH1_Human2.38294812
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31123110
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.20407213
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14587825
28UTX_26944678_Chip-Seq_JUKART_Human2.14293623
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11623450
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09140660
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03649866
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93970092
33VDR_21846776_ChIP-Seq_THP-1_Human1.87430782
34TCF7_22412390_ChIP-Seq_EML_Mouse1.85429544
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83736092
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81006188
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80658897
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80295906
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77776512
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.77421307
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76030704
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68131872
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66195892
44SCL_19346495_ChIP-Seq_HPC-7_Human1.66160806
45GATA3_27048872_Chip-Seq_THYMUS_Human1.63523080
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62394857
47* RUNX1_22412390_ChIP-Seq_EML_Mouse1.59699923
48GATA1_22025678_ChIP-Seq_K562_Human1.59546795
49SPI1_23547873_ChIP-Seq_NB4_Human1.53380993
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53231391
51VDR_24763502_ChIP-Seq_THP-1_Human1.49594478
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49377969
53MAF_26560356_Chip-Seq_TH2_Human1.47611635
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42396522
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42317436
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40857365
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39670425
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.36118869
59SPI1_23127762_ChIP-Seq_K562_Human1.35839952
60PU_27001747_Chip-Seq_BMDM_Mouse1.35784255
61* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35254168
62KDM2B_26808549_Chip-Seq_DND41_Human1.33722002
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33645735
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28281305
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27878771
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25805757
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25012167
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23982699
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23052482
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16694021
71GATA3_26560356_Chip-Seq_TH2_Human1.13644584
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11370507
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10856709
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10602764
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.10081087
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08651137
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07403574
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.03216317
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01234382
80SMRT_27268052_Chip-Seq_Bcells_Human0.99441053
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98952744
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.98187587
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95957244
84STAT1_20625510_ChIP-Seq_HELA_Human0.95840006
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95687910
86NCOR1_26117541_ChIP-Seq_K562_Human0.93778104
87CJUN_26792858_Chip-Seq_BT549_Human0.93540237
88GATA2_19941826_ChIP-Seq_K562_Human0.91171073
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90691722
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90465740
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90382425
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89581673
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.88807804
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88730143
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88378924
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87916657
97CIITA_25753668_ChIP-Seq_RAJI_Human0.86690357
98CLOCK_20551151_ChIP-Seq_293T_Human0.86642558
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.86525478
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86175211
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85885131
102VDR_24787735_ChIP-Seq_THP-1_Human0.85809573
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85721243
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85721243
105* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85403446
106FOXM1_23109430_ChIP-Seq_U2OS_Human0.85361069
107TP53_16413492_ChIP-PET_HCT116_Human0.84774582
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84590929
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84190741
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83608331
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83282819
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83235135
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82106669
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.82105070
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81960822
116GATA1_19941826_ChIP-Seq_K562_Human0.81078609
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80086474
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79964504
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79677569
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79417845
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79400570
122ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78766135
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76392711
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76346567
125TP63_23658742_ChIP-Seq_EP156T_Human0.74273882
126GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73452418
127SPI1_20517297_ChIP-Seq_HL60_Human0.70180273
128BCL6_27268052_Chip-Seq_Bcells_Human0.69956930
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69221116
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.68676914
131TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67472579
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.66963870
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66673946
134ER_23166858_ChIP-Seq_MCF-7_Human0.66532570
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65932068
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.65443332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.51212964
2MP0001835_abnormal_antigen_presentation3.38443154
3MP0002139_abnormal_hepatobiliary_system3.28808074
4MP0001800_abnormal_humoral_immune3.08379058
5MP0001790_abnormal_immune_system2.94010466
6MP0005387_immune_system_phenotype2.94010466
7MP0003763_abnormal_thymus_physiology2.85924739
8MP0005671_abnormal_response_to2.82600634
9MP0005365_abnormal_bile_salt2.79342274
10MP0005085_abnormal_gallbladder_physiolo2.78425205
11MP0000685_abnormal_immune_system2.62613606
12MP0002452_abnormal_antigen_presenting2.40756895
13MP0003303_peritoneal_inflammation2.36080671
14MP0003252_abnormal_bile_duct2.35456266
15MP0002723_abnormal_immune_serum2.32146381
16MP0003191_abnormal_cellular_cholesterol2.26728991
17MP0005000_abnormal_immune_tolerance2.26323123
18MP0003300_gastrointestinal_ulcer2.20891553
19MP0002420_abnormal_adaptive_immunity2.19833806
20MP0001819_abnormal_immune_cell2.16809829
21MP0003436_decreased_susceptibility_to2.13245385
22MP0009840_abnormal_foam_cell2.11050679
23MP0002398_abnormal_bone_marrow2.01161071
24MP0005167_abnormal_blood-brain_barrier1.93883568
25MP0000569_abnormal_digit_pigmentation1.92628914
26MP0009785_altered_susceptibility_to1.91147965
27MP0001873_stomach_inflammation1.90385804
28MP0000716_abnormal_immune_system1.89988855
29MP0005025_abnormal_response_to1.88990549
30MP0008875_abnormal_xenobiotic_pharmacok1.88732236
31MP0000343_altered_response_to1.85207649
32MP0002138_abnormal_hepatobiliary_system1.82158487
33MP0000689_abnormal_spleen_morphology1.79108183
34MP0002419_abnormal_innate_immunity1.77948845
35MP0006082_CNS_inflammation1.77543162
36MP0002166_altered_tumor_susceptibility1.76589765
37MP0005464_abnormal_platelet_physiology1.71905687
38MP0009333_abnormal_splenocyte_physiolog1.70506216
39MP0002405_respiratory_system_inflammati1.67604749
40MP0000609_abnormal_liver_physiology1.65850847
41MP0002396_abnormal_hematopoietic_system1.65466092
42MP0002722_abnormal_immune_system1.65076927
43MP0004947_skin_inflammation1.63755871
44MP0010155_abnormal_intestine_physiology1.63692658
45MP0001845_abnormal_inflammatory_respons1.63061716
46MP0003172_abnormal_lysosome_physiology1.61917595
47MP0004883_abnormal_blood_vessel1.61529643
48MP0005164_abnormal_response_to1.58542025
49MP0003724_increased_susceptibility_to1.58459339
50MP0003075_altered_response_to1.58401528
51MP0002148_abnormal_hypersensitivity_rea1.55986331
52MP0001853_heart_inflammation1.54285720
53MP0002429_abnormal_blood_cell1.53966996
54MP0006054_spinal_hemorrhage1.48422125
55MP0010329_abnormal_lipoprotein_level1.46246667
56MP0008260_abnormal_autophagy1.41243606
57MP0000703_abnormal_thymus_morphology1.40011685
58MP0002998_abnormal_bone_remodeling1.39000424
59MP0008469_abnormal_protein_level1.35464529
60MP0000604_amyloidosis1.30625208
61MP0001666_abnormal_nutrient_absorption1.28284023
62MP0008004_abnormal_stomach_pH1.27986757
63MP0002006_tumorigenesis1.26666201
64MP0002933_joint_inflammation1.23492617
65MP0004510_myositis1.20592617
66MP0009764_decreased_sensitivity_to1.17693079
67MP0004808_abnormal_hematopoietic_stem1.17154033
68MP0003866_abnormal_defecation1.15960306
69MP0003868_abnormal_feces_composition1.14848734
70MP0005451_abnormal_body_composition1.12339913
71MP0002277_abnormal_respiratory_mucosa1.09858379
72MP0005166_decreased_susceptibility_to1.08756682
73MP0003690_abnormal_glial_cell1.02477379
74MP0002928_abnormal_bile_duct1.02451056
75MP0000858_altered_metastatic_potential0.98167833
76MP0000465_gastrointestinal_hemorrhage0.98103017
77MP0009763_increased_sensitivity_to0.98102235
78MP0001533_abnormal_skeleton_physiology0.95802258
79MP0005670_abnormal_white_adipose0.95296111
80MP0009643_abnormal_urine_homeostasis0.95237062
81MP0005310_abnormal_salivary_gland0.94359168
82MP0005390_skeleton_phenotype0.94271546
83MP0002136_abnormal_kidney_physiology0.94236452
84MP0009278_abnormal_bone_marrow0.91650443
85MP0004185_abnormal_adipocyte_glucose0.90578963
86MP0005083_abnormal_biliary_tract0.89768841
87MP0000598_abnormal_liver_morphology0.89324865
88MP0008961_abnormal_basal_metabolism0.88982570
89MP0005023_abnormal_wound_healing0.87982332
90MP0003011_delayed_dark_adaptation0.87273955
91MP0003195_calcinosis0.87151258
92MP0002118_abnormal_lipid_homeostasis0.87093825
93MP0005332_abnormal_amino_acid0.86424801
94MP0005397_hematopoietic_system_phenotyp0.85376588
95MP0001545_abnormal_hematopoietic_system0.85376588
96MP0005319_abnormal_enzyme/_coenzyme0.83249997
97MP0003045_fibrosis0.82837390
98MP0003950_abnormal_plasma_membrane0.82412257
99MP0010368_abnormal_lymphatic_system0.82157132
100MP0000015_abnormal_ear_pigmentation0.81985911
101MP0002332_abnormal_exercise_endurance0.81203447
102MP0001663_abnormal_digestive_system0.80159337
103MP0001851_eye_inflammation0.79872963
104MP0005165_increased_susceptibility_to0.79784759
105MP0003795_abnormal_bone_structure0.79400763
106MP0003183_abnormal_peptide_metabolism0.78470404
107MP0000249_abnormal_blood_vessel0.78360088
108MP0003453_abnormal_keratinocyte_physiol0.74970305
109MP0002877_abnormal_melanocyte_morpholog0.74830678
110MP0003656_abnormal_erythrocyte_physiolo0.73511052
111MP0004019_abnormal_vitamin_homeostasis0.73070397
112MP0003448_altered_tumor_morphology0.71743151
113MP0005584_abnormal_enzyme/coenzyme_acti0.71243938
114MP0002019_abnormal_tumor_incidence0.70759392
115MP0005174_abnormal_tail_pigmentation0.70275099
116MP0003806_abnormal_nucleotide_metabolis0.69914853
117MP0005058_abnormal_lysosome_morphology0.68814221
118MP0002132_abnormal_respiratory_system0.68041732
119MP0003828_pulmonary_edema0.67564686
120MP0003566_abnormal_cell_adhesion0.67495717
121MP0001958_emphysema0.67339492
122MP0005595_abnormal_vascular_smooth0.65030490
123MP0005666_abnormal_adipose_tissue0.64355983
124MP0004484_altered_response_of0.64050366
125MP0003279_aneurysm0.63869531
126MP0002168_other_aberrant_phenotype0.63569181
127MP0001879_abnormal_lymphatic_vessel0.63320810
128MP0009642_abnormal_blood_homeostasis0.63082678
129MP0001542_abnormal_bone_strength0.61934283
130MP0009765_abnormal_xenobiotic_induced0.61781382
131MP0004130_abnormal_muscle_cell0.59286943
132MP0000371_diluted_coat_color0.59026574

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.10855719
2Optic neuritis (HP:0100653)5.10855719
3Abnormality of macrophages (HP:0004311)4.95118971
4Abnormality of glycolipid metabolism (HP:0010969)4.55863668
5Abnormality of liposaccharide metabolism (HP:0010968)4.55863668
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.55863668
7Agammaglobulinemia (HP:0004432)4.41716442
8Recurrent bronchitis (HP:0002837)4.23375576
9T lymphocytopenia (HP:0005403)4.07863972
10Abnormality of T cell number (HP:0011839)3.91650404
11Colitis (HP:0002583)3.85032143
12Recurrent viral infections (HP:0004429)3.81973301
13IgM deficiency (HP:0002850)3.75698977
14Recurrent sinusitis (HP:0011108)3.69510501
15Keratoconjunctivitis sicca (HP:0001097)3.68658512
16Inflammation of the large intestine (HP:0002037)3.62940023
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.57793689
18Pustule (HP:0200039)3.53986287
19Keratoconjunctivitis (HP:0001096)3.52063826
20Deep venous thrombosis (HP:0002625)3.51944459
21Recurrent fungal infections (HP:0002841)3.43633737
22Gastrointestinal inflammation (HP:0004386)3.41367068
23Vacuolated lymphocytes (HP:0001922)3.37904491
24Hemoptysis (HP:0002105)3.33147850
25Abnormality of T cells (HP:0002843)3.30810035
26Myocardial infarction (HP:0001658)3.26930601
27Autoimmune thrombocytopenia (HP:0001973)3.26271223
28Verrucae (HP:0200043)3.23124228
29Papilloma (HP:0012740)3.23124228
30Chronic obstructive pulmonary disease (HP:0006510)3.20979514
31Obstructive lung disease (HP:0006536)3.20979514
32Panhypogammaglobulinemia (HP:0003139)3.16934333
33Increased cerebral lipofuscin (HP:0011813)3.15902357
34Complement deficiency (HP:0004431)3.13854930
35Abnormality of the fingertips (HP:0001211)3.12842119
36Meningitis (HP:0001287)3.07790783
37Spontaneous hematomas (HP:0007420)3.07600395
38Gastrointestinal stroma tumor (HP:0100723)3.07503910
39Lymphopenia (HP:0001888)3.06666330
40Nasal polyposis (HP:0100582)3.06327757
41Recurrent cutaneous fungal infections (HP:0011370)3.04551088
42Chronic mucocutaneous candidiasis (HP:0002728)3.04551088
43Chronic otitis media (HP:0000389)3.00672605
44Urticaria (HP:0001025)2.99726913
45Intrahepatic cholestasis (HP:0001406)2.98946889
46Eczematoid dermatitis (HP:0000976)2.96885249
47Chronic diarrhea (HP:0002028)2.96470640
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95514025
49Petechiae (HP:0000967)2.95334093
50Gingivitis (HP:0000230)2.94832526
51Cellulitis (HP:0100658)2.94226115
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.89789483
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.89126930
54Elevated erythrocyte sedimentation rate (HP:0003565)2.87375081
55Vasculitis (HP:0002633)2.86887652
56Prolonged partial thromboplastin time (HP:0003645)2.78606250
57Myositis (HP:0100614)2.76335052
58Dysostosis multiplex (HP:0000943)2.75114010
59Recurrent gram-negative bacterial infections (HP:0005420)2.72368594
60Recurrent bacterial skin infections (HP:0005406)2.70577590
61Joint hemorrhage (HP:0005261)2.70190162
62Increased neuronal autofluorescent lipopigment (HP:0002074)2.69970033
63Abnormality of the nasal mucosa (HP:0000433)2.69770382
64Xanthomatosis (HP:0000991)2.67299879
65Recurrent abscess formation (HP:0002722)2.67061164
66Abnormality of T cell physiology (HP:0011840)2.66131238
67Loss of speech (HP:0002371)2.64628062
68Encephalitis (HP:0002383)2.64088292
69Recurrent skin infections (HP:0001581)2.61688648
70Mitral stenosis (HP:0001718)2.59538609
71Episodic fever (HP:0001954)2.58480741
72Combined immunodeficiency (HP:0005387)2.57076120
73Peritonitis (HP:0002586)2.54389970
74IgG deficiency (HP:0004315)2.54052811
75Recurrent otitis media (HP:0000403)2.50637596
76Anorexia (HP:0002039)2.47952534
77Gingival bleeding (HP:0000225)2.47712147
78Emphysema (HP:0002097)2.47454244
79Bronchitis (HP:0012387)2.47269789
80Abnormality of the common coagulation pathway (HP:0010990)2.47101681
81Abnormal platelet volume (HP:0011876)2.44795418
82Abnormal platelet function (HP:0011869)2.44096493
83Impaired platelet aggregation (HP:0003540)2.44096493
84Abnormality of iron homeostasis (HP:0011031)2.43802831
85Gangrene (HP:0100758)2.43260448
86IgA deficiency (HP:0002720)2.41446914
87Thyroiditis (HP:0100646)2.41047453
88Systemic lupus erythematosus (HP:0002725)2.40022289
89Abnormality of polysaccharide metabolism (HP:0011012)2.38338728
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38338728
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38338728
92Abnormality of the pericardium (HP:0001697)2.35839201
93Hypobetalipoproteinemia (HP:0003563)2.35372034
94Epistaxis (HP:0000421)2.33530703
95Polyneuropathy (HP:0001271)2.33369565
96Joint swelling (HP:0001386)2.32866074
97Severe combined immunodeficiency (HP:0004430)2.32586964
98Increased serum ferritin (HP:0003281)2.32503813
99Abnormality of transition element cation homeostasis (HP:0011030)2.30947823
100Hyperlipoproteinemia (HP:0010980)2.30454685
101Amyloidosis (HP:0011034)2.29911565
102Chest pain (HP:0100749)2.29461232
103Stomatitis (HP:0010280)2.29336811
104Chronic sinusitis (HP:0011109)2.27848111
105Abnormality of B cell number (HP:0010975)2.27188091
106B lymphocytopenia (HP:0010976)2.27188091
107Glomerulonephritis (HP:0000099)2.26816240
108Increased IgM level (HP:0003496)2.22388799
109Pulmonary embolism (HP:0002204)2.21566761
110Purpura (HP:0000979)2.21118181
111Abnormality of complement system (HP:0005339)2.18290596
112Vertigo (HP:0002321)2.17698252
113Eosinophilia (HP:0001880)2.16808426
114Keratitis (HP:0000491)2.16524880
115Mediastinal lymphadenopathy (HP:0100721)2.15429963
116Cheilitis (HP:0100825)2.14590461
117Hematochezia (HP:0002573)2.14517284
118Abnormality of the pleura (HP:0002103)2.14176329
119Increased mean platelet volume (HP:0011877)2.13617857
120Mucopolysacchariduria (HP:0008155)2.13462416
121Urinary glycosaminoglycan excretion (HP:0003541)2.13462416
122Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12519772
123Pulmonary infiltrates (HP:0002113)2.12344578
124Prolonged bleeding time (HP:0003010)2.10929882
125Osteomyelitis (HP:0002754)2.09692843
126Hepatitis (HP:0012115)2.06999929
127Arterial thrombosis (HP:0004420)2.05831963
128Gastrointestinal infarctions (HP:0005244)2.05229217
129Aortic aneurysm (HP:0004942)2.01439031
130Abnormality of eosinophils (HP:0001879)2.01415038
131Leukocytosis (HP:0001974)2.00255200
132Orchitis (HP:0100796)1.99890929
133Abnormality of sulfur amino acid metabolism (HP:0004339)1.94165376
134Periodontitis (HP:0000704)1.93143448
135Fat malabsorption (HP:0002630)1.92892040
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90172502
137Microcytic anemia (HP:0001935)1.89802948
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87197491
139Polycythemia (HP:0001901)1.86999379
140Thrombocytosis (HP:0001894)1.85941260
141Glomerulopathy (HP:0100820)1.85816300
142Recurrent pneumonia (HP:0006532)1.85265138
143Increased IgE level (HP:0003212)1.85062032
144Acne (HP:0001061)1.84359297
145Hypergammaglobulinemia (HP:0010702)1.84072868
146Menorrhagia (HP:0000132)1.83688616
147Hepatosplenomegaly (HP:0001433)1.82035441
148Granulocytopenia (HP:0001913)1.82022114
149Hypochromic microcytic anemia (HP:0004840)1.80027038
150Conjunctival telangiectasia (HP:0000524)1.78224682
151Abnormality of the endocardium (HP:0004306)1.77353380
152Hypochromic anemia (HP:0001931)1.77230645
153Autoimmune hemolytic anemia (HP:0001890)1.77077427
154Increased CSF protein (HP:0002922)1.76162319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.64823851
2TXK3.10391064
3ERN12.95432124
4FGFR42.63147586
5STK102.62929736
6TYK22.49850306
7GRK62.41897762
8MAP3K102.24475852
9JAK12.23874862
10ZAP702.15814213
11JAK32.10642309
12TAOK32.08998528
13TIE12.07047417
14TGFBR22.07009286
15ITK2.06195198
16IRAK11.98936593
17BLK1.92785629
18MAP3K141.89871775
19IRAK31.78542056
20ADRBK21.77330091
21CSK1.70994794
22MARK31.68734407
23IKBKE1.65166139
24CSF1R1.62890491
25ACVR1B1.59174569
26NLK1.58529376
27GRK71.58258708
28SIK11.55455844
29TBK11.54354348
30FGFR31.51839175
31CDK121.51385826
32BTK1.51052730
33MAP3K31.49662470
34TRIB31.44603952
35EEF2K1.44344698
36SYK1.43749307
37NEK91.42413933
38FGR1.40743289
39MAP3K131.40072447
40MATK1.38692197
41IRAK41.31744531
42TEC1.31197572
43MAP3K111.27480105
44CAMKK21.26239923
45RPS6KA41.22565026
46PKN21.19119481
47KIT1.19078124
48LCK1.18738532
49FLT31.16961050
50HCK1.16921602
51IKBKB1.16095636
52PIK3CG1.13375409
53SIK21.09404715
54PIM11.09070943
55PTK2B1.08203155
56LRRK21.06909636
57EPHB11.05899438
58KDR1.00462647
59JAK20.98459517
60PRKCQ0.97479610
61MAP3K60.95631729
62BMPR20.94416251
63LYN0.93850086
64MAP2K60.93830697
65PTK60.92962308
66FRK0.90756772
67CHUK0.88137305
68PRKCH0.87996152
69PRKD20.86600408
70DAPK20.83688778
71MAPK70.83216567
72MST40.80228211
73MAP3K70.79382813
74MAPK120.78287265
75CDK40.75248788
76ADRBK10.74307231
77CLK10.73917944
78MAPK110.72771055
79FER0.72536665
80CAMK1D0.72383731
81MELK0.72318562
82MAP3K10.71172915
83MAP2K30.70383163
84PDK10.69818460
85CDK90.68636668
86PDK20.67469137
87TGFBR10.66842688
88SIK30.66827317
89MAP2K40.65394776
90TLK10.63400110
91CDK60.63079382
92PINK10.61782787
93SGK30.61521855
94MAP3K20.60980754
95NEK20.59524736
96EPHA30.58860857
97CAMK1G0.56670991
98RIPK40.56584044
99MAP3K50.54929668
100PRKAA20.53494034
101HIPK20.53288120
102STK30.48941708
103FES0.47812300
104YES10.46955386
105NUAK10.46378105
106MAPK150.45880791
107TRPM70.45209619
108TTN0.44553435
109STK40.42919689
110ABL10.42367497
111MOS0.40107430
112PDGFRB0.38804806
113INSRR0.38435175
114OXSR10.38080516
115IRAK20.37705145
116BRSK20.37084618
117STK110.37030231
118MAPKAPK20.36871192
119LATS10.36284625
120PRKCD0.35263796
121DDR20.35209952
122PRKD10.34983494
123PRKG20.34058824
124INSR0.33965141
125MTOR0.33802388
126PDPK10.33762219
127TAOK10.33194042
128GRK50.32506387
129TNK20.32399495
130CDC42BPA0.32026123
131BMPR1B0.31812300
132FYN0.31338136
133STK240.30630895
134MAPK40.29999994
135IGF1R0.29508864
136BRD40.29106689
137KSR20.27246352
138SGK20.26899886
139GRK10.25951922

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.08501059
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.87705958
3B cell receptor signaling pathway_Homo sapiens_hsa046622.81922400
4Staphylococcus aureus infection_Homo sapiens_hsa051502.73761112
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35159044
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.27343205
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.25185788
8Complement and coagulation cascades_Homo sapiens_hsa046102.11548654
9Rheumatoid arthritis_Homo sapiens_hsa053232.02837233
10T cell receptor signaling pathway_Homo sapiens_hsa046602.01855081
11Asthma_Homo sapiens_hsa053101.94539576
12Nitrogen metabolism_Homo sapiens_hsa009101.93633094
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93259760
14Antigen processing and presentation_Homo sapiens_hsa046121.84226244
15Lysosome_Homo sapiens_hsa041421.82358041
16Osteoclast differentiation_Homo sapiens_hsa043801.80436552
17Tryptophan metabolism_Homo sapiens_hsa003801.80143024
18Hematopoietic cell lineage_Homo sapiens_hsa046401.75681189
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67688534
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67658236
21Measles_Homo sapiens_hsa051621.66972575
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66655791
23Caffeine metabolism_Homo sapiens_hsa002321.66067026
24Phagosome_Homo sapiens_hsa041451.64497201
25Lysine degradation_Homo sapiens_hsa003101.54441838
26Arginine biosynthesis_Homo sapiens_hsa002201.53470769
27Type I diabetes mellitus_Homo sapiens_hsa049401.48493323
28Leishmaniasis_Homo sapiens_hsa051401.46905312
29African trypanosomiasis_Homo sapiens_hsa051431.39967540
30Fatty acid degradation_Homo sapiens_hsa000711.39626061
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36733630
32ABC transporters_Homo sapiens_hsa020101.35274489
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21346901
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.20548862
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.14183672
36Salmonella infection_Homo sapiens_hsa051321.08370947
37PPAR signaling pathway_Homo sapiens_hsa033201.07870816
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.07464239
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06367372
40Herpes simplex infection_Homo sapiens_hsa051681.06179921
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06013965
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05690162
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02192674
44Toxoplasmosis_Homo sapiens_hsa051451.00971282
45Acute myeloid leukemia_Homo sapiens_hsa052211.00848647
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99998150
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99206049
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99143091
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98142381
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.97741619
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.97464965
52Graft-versus-host disease_Homo sapiens_hsa053320.97057720
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96843381
54Chemical carcinogenesis_Homo sapiens_hsa052040.96410513
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96142419
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94840209
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94699173
58Influenza A_Homo sapiens_hsa051640.93861236
59Retinol metabolism_Homo sapiens_hsa008300.93513976
60Pancreatic cancer_Homo sapiens_hsa052120.88976641
61Sulfur metabolism_Homo sapiens_hsa009200.88645412
62Histidine metabolism_Homo sapiens_hsa003400.88000521
63Chemokine signaling pathway_Homo sapiens_hsa040620.87303217
64Hepatitis B_Homo sapiens_hsa051610.86749379
65Viral myocarditis_Homo sapiens_hsa054160.86357249
66Insulin resistance_Homo sapiens_hsa049310.85111416
67beta-Alanine metabolism_Homo sapiens_hsa004100.84489317
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82915955
69Platelet activation_Homo sapiens_hsa046110.82899370
70TNF signaling pathway_Homo sapiens_hsa046680.81239471
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81052016
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80936104
73Selenocompound metabolism_Homo sapiens_hsa004500.80056718
74Peroxisome_Homo sapiens_hsa041460.79987480
75Chronic myeloid leukemia_Homo sapiens_hsa052200.77688564
76Ether lipid metabolism_Homo sapiens_hsa005650.76405322
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74521189
78Arachidonic acid metabolism_Homo sapiens_hsa005900.72672849
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72450836
80Starch and sucrose metabolism_Homo sapiens_hsa005000.71805260
81Tuberculosis_Homo sapiens_hsa051520.71327817
82Apoptosis_Homo sapiens_hsa042100.70721386
83Hepatitis C_Homo sapiens_hsa051600.70563146
84Allograft rejection_Homo sapiens_hsa053300.69281692
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69034591
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69010823
87Collecting duct acid secretion_Homo sapiens_hsa049660.68329750
88Amoebiasis_Homo sapiens_hsa051460.67894728
89Other glycan degradation_Homo sapiens_hsa005110.65332872
90Dorso-ventral axis formation_Homo sapiens_hsa043200.65190292
91Linoleic acid metabolism_Homo sapiens_hsa005910.64258500
92Pentose phosphate pathway_Homo sapiens_hsa000300.62987848
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62702349
94Bile secretion_Homo sapiens_hsa049760.60245010
95Propanoate metabolism_Homo sapiens_hsa006400.60212647
96Fatty acid metabolism_Homo sapiens_hsa012120.59841014
97Prolactin signaling pathway_Homo sapiens_hsa049170.59619662
98FoxO signaling pathway_Homo sapiens_hsa040680.57863369
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.57296262
100Fat digestion and absorption_Homo sapiens_hsa049750.56477124
101Mineral absorption_Homo sapiens_hsa049780.53911152
102VEGF signaling pathway_Homo sapiens_hsa043700.53100423
103Pertussis_Homo sapiens_hsa051330.52791897
104* NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52403430
105Non-small cell lung cancer_Homo sapiens_hsa052230.51959712
106Vitamin digestion and absorption_Homo sapiens_hsa049770.50878001
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50713994
108Folate biosynthesis_Homo sapiens_hsa007900.50086307
109Glycerolipid metabolism_Homo sapiens_hsa005610.49048524
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47430209
111Malaria_Homo sapiens_hsa051440.46395138
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45515349
113Legionellosis_Homo sapiens_hsa051340.45307314
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.44494869
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43741247
116Endocytosis_Homo sapiens_hsa041440.43588093
117Ovarian steroidogenesis_Homo sapiens_hsa049130.43209171
118Sphingolipid metabolism_Homo sapiens_hsa006000.43099736
119Vitamin B6 metabolism_Homo sapiens_hsa007500.43072315
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.43024087
121Regulation of autophagy_Homo sapiens_hsa041400.42633209
122HTLV-I infection_Homo sapiens_hsa051660.42585186
123Small cell lung cancer_Homo sapiens_hsa052220.41105887
124Butanoate metabolism_Homo sapiens_hsa006500.40547997
125Phenylalanine metabolism_Homo sapiens_hsa003600.40384208
126Epstein-Barr virus infection_Homo sapiens_hsa051690.39726802
127Shigellosis_Homo sapiens_hsa051310.39220519
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37959957
129Inositol phosphate metabolism_Homo sapiens_hsa005620.34992319
130Autoimmune thyroid disease_Homo sapiens_hsa053200.34713350
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33861396
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31301147
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30108269
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.29632604
135GnRH signaling pathway_Homo sapiens_hsa049120.29313858
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28740252
137HIF-1 signaling pathway_Homo sapiens_hsa040660.27865320
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.23602296

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