CARD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.58513713
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.98110770
3negative regulation of cell killing (GO:0031342)5.98110770
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.97451155
5regulation of B cell receptor signaling pathway (GO:0050855)5.61212775
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05517609
7antigen processing and presentation of endogenous antigen (GO:0019883)5.02897698
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.00542682
9regulation of gamma-delta T cell activation (GO:0046643)4.75897745
10regulation of gamma-delta T cell differentiation (GO:0045586)4.59982566
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52506044
12negative T cell selection (GO:0043383)4.46065601
13negative thymic T cell selection (GO:0045060)4.45595100
14positive regulation by symbiont of host defense response (GO:0052509)4.44645368
15modulation by symbiont of host defense response (GO:0052031)4.44645368
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44645368
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44645368
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.44645368
19modulation by symbiont of host immune response (GO:0052553)4.44645368
20response to interleukin-15 (GO:0070672)4.44270293
21neutrophil activation involved in immune response (GO:0002283)4.36931809
22positive regulation of B cell differentiation (GO:0045579)4.26301435
23B cell receptor signaling pathway (GO:0050853)4.22126839
24cellular response to interleukin-15 (GO:0071350)4.21025554
25positive thymic T cell selection (GO:0045059)4.11513781
26detection of other organism (GO:0098543)4.10991715
27regulation of B cell differentiation (GO:0045577)4.04477842
28cellular extravasation (GO:0045123)3.99227583
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.95029929
30immunoglobulin mediated immune response (GO:0016064)3.92355089
31leukocyte aggregation (GO:0070486)3.89587661
32positive T cell selection (GO:0043368)3.87016489
33detection of bacterium (GO:0016045)3.84343423
34negative regulation of T cell mediated immunity (GO:0002710)3.82408976
35activated T cell proliferation (GO:0050798)3.80542229
36negative regulation of interleukin-12 production (GO:0032695)3.76161130
37macrophage activation involved in immune response (GO:0002281)3.75783178
38neutrophil activation (GO:0042119)3.69854699
39microglial cell activation (GO:0001774)3.68254987
40T cell migration (GO:0072678)3.68154308
41detection of external biotic stimulus (GO:0098581)3.59745985
42detection of molecule of bacterial origin (GO:0032490)3.59525480
43positive regulation of granulocyte differentiation (GO:0030854)3.56080725
44regulation of alpha-beta T cell proliferation (GO:0046640)3.54328994
45T cell selection (GO:0045058)3.49231190
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49186951
47negative regulation of leukocyte mediated immunity (GO:0002704)3.46509417
48regulation of regulatory T cell differentiation (GO:0045589)3.43970506
49regulation of interferon-beta biosynthetic process (GO:0045357)3.43447798
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41153983
51response to peptidoglycan (GO:0032494)3.38937742
52myeloid cell activation involved in immune response (GO:0002275)3.37840761
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35343941
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31544806
55negative regulation of T-helper cell differentiation (GO:0045623)3.30375327
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30375327
57regulation of T cell mediated cytotoxicity (GO:0001914)3.30126824
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29572237
59response to host immune response (GO:0052572)3.29572237
60mast cell activation (GO:0045576)3.29130573
61thymic T cell selection (GO:0045061)3.25525028
62granulocyte activation (GO:0036230)3.23851863
63regulation of T cell tolerance induction (GO:0002664)3.22588836
64antigen processing and presentation via MHC class Ib (GO:0002475)3.22035296
65regulation of tolerance induction (GO:0002643)3.21629048
66leukocyte migration involved in inflammatory response (GO:0002523)3.20789773
67neutrophil mediated immunity (GO:0002446)3.18915629
68positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18855669
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.18089812
70response to type I interferon (GO:0034340)3.17550124
71B cell mediated immunity (GO:0019724)3.17486405
72regulation of mast cell activation (GO:0033003)3.17278083
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16715785
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15660517
75cellular response to type I interferon (GO:0071357)3.15516677
76type I interferon signaling pathway (GO:0060337)3.15516677
77leukocyte degranulation (GO:0043299)3.14846954
78positive regulation of mast cell activation (GO:0033005)3.14353233
79detection of biotic stimulus (GO:0009595)3.12586081
80interferon-gamma production (GO:0032609)3.12268147
81interferon-gamma-mediated signaling pathway (GO:0060333)3.10959684
82antigen receptor-mediated signaling pathway (GO:0050851)3.08371376
83positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08311000
84macrophage activation (GO:0042116)3.07971774
85tolerance induction (GO:0002507)3.07653850
86dendritic cell migration (GO:0036336)3.04945758
87respiratory burst (GO:0045730)3.03291085
88defense response to protozoan (GO:0042832)2.98939258
89regulation of mast cell degranulation (GO:0043304)2.95565410
90myeloid leukocyte mediated immunity (GO:0002444)2.95184067
91negative regulation of adaptive immune response (GO:0002820)2.95102975
92response to muramyl dipeptide (GO:0032495)2.94332888
93positive regulation of tolerance induction (GO:0002645)2.94073470
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92755182
95response to host (GO:0075136)2.92755182
96response to host defenses (GO:0052200)2.92755182
97regulation of natural killer cell mediated immunity (GO:0002715)2.91158248
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91158248
99germinal center formation (GO:0002467)2.90929975
100negative regulation of innate immune response (GO:0045824)2.88971325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.32518027
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.84484974
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.63621121
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58944775
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.10076440
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61040004
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41506850
8RUNX_20019798_ChIP-Seq_JUKART_Human3.37379671
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25079400
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.92423754
11SCL_19346495_ChIP-Seq_HPC-7_Human2.92271036
12MYB_26560356_Chip-Seq_TH2_Human2.81507411
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72905698
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.69865228
15* SPI1_23547873_ChIP-Seq_NB4_Human2.43574966
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36231504
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31208145
18MYB_26560356_Chip-Seq_TH1_Human2.20909944
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19869802
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13018899
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12015844
22GATA3_27048872_Chip-Seq_THYMUS_Human2.11679214
23SPI1_23127762_ChIP-Seq_K562_Human2.10433774
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.98301833
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94296401
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94136055
27GATA3_26560356_Chip-Seq_TH2_Human1.93708340
28VDR_24763502_ChIP-Seq_THP-1_Human1.88827642
29MAF_26560356_Chip-Seq_TH1_Human1.86357332
30VDR_24787735_ChIP-Seq_THP-1_Human1.85346862
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85160032
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81350381
33UTX_26944678_Chip-Seq_JUKART_Human1.72791904
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71038657
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70295066
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.63535701
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63273540
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61475706
39GATA1_22025678_ChIP-Seq_K562_Human1.55979367
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53871849
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51998656
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.47588857
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46541113
44VDR_21846776_ChIP-Seq_THP-1_Human1.40328053
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38458385
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37372488
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.35708076
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30635442
49MAF_26560356_Chip-Seq_TH2_Human1.30568960
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28366262
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28014265
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26237290
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25863801
54MYC_22102868_ChIP-Seq_BL_Human1.25587536
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22759219
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22475543
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.21785197
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19461807
59PU_27001747_Chip-Seq_BMDM_Mouse1.15830155
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.13554808
61* SMRT_27268052_Chip-Seq_Bcells_Human1.12614240
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06554881
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03047172
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99254704
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97993068
66GATA3_26560356_Chip-Seq_TH1_Human0.95465754
67GATA1_19941826_ChIP-Seq_K562_Human0.95384120
68TCF7_22412390_ChIP-Seq_EML_Mouse0.91167386
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90084453
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89680188
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88028270
72ER_23166858_ChIP-Seq_MCF-7_Human0.87166528
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86725412
74* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86306407
75GATA2_19941826_ChIP-Seq_K562_Human0.85645900
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85589981
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85514903
78* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82141909
79* PRDM14_20953172_ChIP-Seq_ESCs_Human0.81551557
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.81454447
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81041308
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79962382
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79189980
84* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78626645
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77020862
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76743734
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76078809
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75736563
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74779534
90* CIITA_25753668_ChIP-Seq_RAJI_Human0.74302629
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73828730
92IGF1R_20145208_ChIP-Seq_DFB_Human0.72646169
93BCL6_27268052_Chip-Seq_Bcells_Human0.72179499
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71928677
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71667292
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70589323
97ZNF274_21170338_ChIP-Seq_K562_Hela0.69385077
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69339883
99* SPI1_20517297_ChIP-Seq_HL60_Human0.68810914
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68464161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.95947938
2MP0001835_abnormal_antigen_presentation4.15108351
3MP0005671_abnormal_response_to3.67942106
4MP0003436_decreased_susceptibility_to3.41918105
5MP0001800_abnormal_humoral_immune3.24740579
6MP0005000_abnormal_immune_tolerance2.88985544
7MP0003763_abnormal_thymus_physiology2.88186513
8MP0003303_peritoneal_inflammation2.86228511
9MP0002419_abnormal_innate_immunity2.79213589
10MP0005387_immune_system_phenotype2.76764786
11MP0001790_abnormal_immune_system2.76764786
12MP0002723_abnormal_immune_serum2.76271183
13MP0000685_abnormal_immune_system2.75319218
14MP0005025_abnormal_response_to2.70510161
15MP0009785_altered_susceptibility_to2.67617842
16MP0002420_abnormal_adaptive_immunity2.64073302
17MP0001819_abnormal_immune_cell2.61209663
18MP0002452_abnormal_antigen_presenting2.60209939
19MP0005464_abnormal_platelet_physiology2.41496708
20MP0002148_abnormal_hypersensitivity_rea2.32497819
21MP0002398_abnormal_bone_marrow2.18793559
22MP0000465_gastrointestinal_hemorrhage2.07430965
23MP0006082_CNS_inflammation2.07416480
24MP0000716_abnormal_immune_system2.07160044
25MP0002405_respiratory_system_inflammati2.04957634
26MP0000689_abnormal_spleen_morphology1.91928365
27MP0000569_abnormal_digit_pigmentation1.91197392
28MP0003828_pulmonary_edema1.89500055
29MP0002396_abnormal_hematopoietic_system1.87730335
30MP0003300_gastrointestinal_ulcer1.85882682
31MP0010155_abnormal_intestine_physiology1.80979448
32MP0002722_abnormal_immune_system1.78294087
33MP0001533_abnormal_skeleton_physiology1.72595023
34MP0000703_abnormal_thymus_morphology1.70597194
35MP0001845_abnormal_inflammatory_respons1.70031022
36MP0009333_abnormal_splenocyte_physiolog1.68893723
37MP0002166_altered_tumor_susceptibility1.68381902
38MP0003866_abnormal_defecation1.63895122
39MP0002429_abnormal_blood_cell1.62254821
40MP0002138_abnormal_hepatobiliary_system1.62130066
41MP0003183_abnormal_peptide_metabolism1.57884943
42MP0009764_decreased_sensitivity_to1.54074192
43MP0004381_abnormal_hair_follicle1.37733089
44MP0003172_abnormal_lysosome_physiology1.35996736
45MP0008469_abnormal_protein_level1.34635520
46MP0002132_abnormal_respiratory_system1.31380970
47MP0005397_hematopoietic_system_phenotyp1.29322429
48MP0001545_abnormal_hematopoietic_system1.29322429
49MP0005310_abnormal_salivary_gland1.26835981
50MP0009278_abnormal_bone_marrow1.25731326
51MP0003191_abnormal_cellular_cholesterol1.24138386
52MP0006054_spinal_hemorrhage1.22763826
53MP0004947_skin_inflammation1.22492870
54MP0005075_abnormal_melanosome_morpholog1.20089307
55MP0004883_abnormal_blood_vessel1.18851658
56MP0002277_abnormal_respiratory_mucosa1.18406735
57MP0001986_abnormal_taste_sensitivity1.15471642
58MP0004808_abnormal_hematopoietic_stem1.15102793
59MP0004130_abnormal_muscle_cell1.10395987
60MP0002006_tumorigenesis1.05498078
61MP0002009_preneoplasia1.04881339
62MP0001851_eye_inflammation1.04861580
63MP0005174_abnormal_tail_pigmentation1.03257078
64MP0003787_abnormal_imprinting1.00471553
65MP0001873_stomach_inflammation0.98731810
66MP0008260_abnormal_autophagy0.96227139
67MP0000015_abnormal_ear_pigmentation0.95515606
68MP0003195_calcinosis0.93986287
69MP0002998_abnormal_bone_remodeling0.88654248
70MP0004484_altered_response_of0.88400425
71MP0002933_joint_inflammation0.87646494
72MP0001663_abnormal_digestive_system0.86618618
73MP0003045_fibrosis0.85388338
74MP0001853_heart_inflammation0.84445202
75MP0000858_altered_metastatic_potential0.83424364
76MP0009763_increased_sensitivity_to0.82256564
77MP0005167_abnormal_blood-brain_barrier0.78798520
78MP0000249_abnormal_blood_vessel0.78103345
79MP0005164_abnormal_response_to0.75244995
80MP0003656_abnormal_erythrocyte_physiolo0.75121837
81MP0008877_abnormal_DNA_methylation0.73866447
82MP0009765_abnormal_xenobiotic_induced0.72553324
83MP0000343_altered_response_to0.70993567
84MP0003252_abnormal_bile_duct0.70173191
85MP0003690_abnormal_glial_cell0.63621078
86MP0002928_abnormal_bile_duct0.62425764
87MP0002019_abnormal_tumor_incidence0.62305716
88MP0003075_altered_response_to0.60822677
89MP0005083_abnormal_biliary_tract0.58646976
90MP0005166_decreased_susceptibility_to0.58526433
91MP0005390_skeleton_phenotype0.56043857
92MP0003448_altered_tumor_morphology0.55218725
93MP0005084_abnormal_gallbladder_morpholo0.54455666
94MP0002693_abnormal_pancreas_physiology0.53775886
95MP0000604_amyloidosis0.52101313
96MP0008004_abnormal_stomach_pH0.49624161
97MP0002332_abnormal_exercise_endurance0.48531448
98MP0009115_abnormal_fat_cell0.47014851
99MP0005376_homeostasis/metabolism_phenot0.45668930
100MP0003795_abnormal_bone_structure0.45523480

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.20532343
2Eczematoid dermatitis (HP:0000976)4.99203746
3Recurrent abscess formation (HP:0002722)4.98617442
4Recurrent bacterial skin infections (HP:0005406)4.96989650
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.85082631
6Stomatitis (HP:0010280)4.73796271
7Retrobulbar optic neuritis (HP:0100654)4.72085152
8Optic neuritis (HP:0100653)4.72085152
9Elevated erythrocyte sedimentation rate (HP:0003565)4.66453610
10Orchitis (HP:0100796)4.63964936
11T lymphocytopenia (HP:0005403)4.55093196
12Abnormality of T cell number (HP:0011839)4.52069037
13Recurrent fungal infections (HP:0002841)4.48966328
14Chronic mucocutaneous candidiasis (HP:0002728)4.22701517
15Recurrent cutaneous fungal infections (HP:0011370)4.22701517
16Panhypogammaglobulinemia (HP:0003139)4.19955048
17Spontaneous hematomas (HP:0007420)4.08258585
18Encephalitis (HP:0002383)4.06818473
19Meningitis (HP:0001287)3.98003218
20Abnormality of macrophages (HP:0004311)3.83600795
21Gastrointestinal infarctions (HP:0005244)3.78948241
22Recurrent skin infections (HP:0001581)3.74351055
23Abnormality of T cells (HP:0002843)3.69568043
24Obstructive lung disease (HP:0006536)3.60695876
25Chronic obstructive pulmonary disease (HP:0006510)3.60695876
26Recurrent gram-negative bacterial infections (HP:0005420)3.56876091
27Keratoconjunctivitis sicca (HP:0001097)3.55868200
28Mediastinal lymphadenopathy (HP:0100721)3.52801446
29Vasculitis (HP:0002633)3.52035306
30Prolonged bleeding time (HP:0003010)3.46253150
31Keratoconjunctivitis (HP:0001096)3.40838848
32Chest pain (HP:0100749)3.35668691
33Leukocytosis (HP:0001974)3.35341821
34Recurrent viral infections (HP:0004429)3.29086553
35Hemoptysis (HP:0002105)3.25664698
36Eosinophilia (HP:0001880)3.15434408
37Agammaglobulinemia (HP:0004432)3.15097461
38Granulocytopenia (HP:0001913)3.14565942
39Pustule (HP:0200039)3.10038011
40Pulmonary infiltrates (HP:0002113)3.03352550
41Stomach cancer (HP:0012126)3.01297424
42Abnormality of eosinophils (HP:0001879)2.99647581
43Abnormality of T cell physiology (HP:0011840)2.99244736
44Epistaxis (HP:0000421)2.98698284
45Autoimmune hemolytic anemia (HP:0001890)2.92932326
46Gingival bleeding (HP:0000225)2.91630399
47Arterial thrombosis (HP:0004420)2.89897564
48Pulmonary embolism (HP:0002204)2.87316148
49Hypochromic microcytic anemia (HP:0004840)2.84948950
50IgG deficiency (HP:0004315)2.83932053
51Hypochromic anemia (HP:0001931)2.81388348
52Inflammation of the large intestine (HP:0002037)2.80673161
53Severe combined immunodeficiency (HP:0004430)2.79036475
54Abnormality of B cell number (HP:0010975)2.74683975
55Urticaria (HP:0001025)2.72801958
56Increased IgM level (HP:0003496)2.66029603
57Gastrointestinal inflammation (HP:0004386)2.59614542
58Abnormality of the prostate (HP:0008775)2.56942187
59Autoimmune thrombocytopenia (HP:0001973)2.56595023
60Gingivitis (HP:0000230)2.52212016
61Abnormality of the pleura (HP:0002103)2.48704465
62Recurrent bronchitis (HP:0002837)2.44409352
63Anorexia (HP:0002039)2.43574424
64Microcytic anemia (HP:0001935)2.41257008
65Hematochezia (HP:0002573)2.40264974
66Increased IgE level (HP:0003212)2.37771032
67Cellulitis (HP:0100658)2.33069461
68Thyroiditis (HP:0100646)2.32570856
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28294915
70Chronic otitis media (HP:0000389)2.26082138
71Gangrene (HP:0100758)2.25408520
72Lymphopenia (HP:0001888)2.23678277
73Chronic diarrhea (HP:0002028)2.23590739
74Colitis (HP:0002583)2.21614578
75Episodic fever (HP:0001954)2.20123765
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.17363365
77Petechiae (HP:0000967)2.16702921
78IgM deficiency (HP:0002850)2.16459360
79Viral hepatitis (HP:0006562)2.12564031
80Sepsis (HP:0100806)2.10263554
81Combined immunodeficiency (HP:0005387)2.09102925
82Osteomyelitis (HP:0002754)2.05389726
83Papilledema (HP:0001085)2.04495783
84Keratitis (HP:0000491)2.03558337
85Prostate neoplasm (HP:0100787)2.00397647
86Verrucae (HP:0200043)1.96491923
87Papilloma (HP:0012740)1.96491923
88Hypergammaglobulinemia (HP:0010702)1.95868312
89Hypoproteinemia (HP:0003075)1.94862855
90Vertigo (HP:0002321)1.94274390
91B lymphocytopenia (HP:0010976)1.93735522
92Acute hepatic failure (HP:0006554)1.88530203
93Abnormality of the peritoneum (HP:0002585)1.87507918
94Amaurosis fugax (HP:0100576)1.86626419
95Peritonitis (HP:0002586)1.86286361
96Thrombophlebitis (HP:0004418)1.84868154
97Abnormality of the endocardium (HP:0004306)1.84543974
98Hemiplegia (HP:0002301)1.83426356
99Glomerulopathy (HP:0100820)1.81976867
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81022377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.92926879
2MAP4K13.91783368
3TXK3.30432817
4BLK3.03875883
5FES2.97012521
6TAOK32.89454731
7MAP2K32.46903916
8TYK22.44431262
9CSK2.33637929
10IRAK42.26498659
11BTK2.25087421
12TEC2.21792014
13SYK2.20325363
14GRK62.17399345
15ZAP702.14018181
16JAK32.04951080
17ITK2.01412775
18FRK1.95784221
19MAP3K141.89180996
20TNK21.88592636
21KIT1.88393101
22IKBKE1.84169192
23HCK1.74473483
24MAP3K131.60861580
25LYN1.58989343
26JAK11.54709464
27LCK1.52460087
28CSF1R1.46423474
29NUAK11.39441596
30IKBKB1.29072294
31PIK3CG1.28221762
32JAK21.20165766
33TBK11.18643193
34CAMKK21.14569701
35IRAK11.11460324
36BMPR21.09986574
37MARK31.06260607
38FGR1.03387510
39FGFR31.03373616
40PRKCQ1.00785756
41ERN10.96203062
42TIE10.95819967
43MAP3K70.89277955
44MAP3K60.89034215
45YES10.87086028
46PTK2B0.86728927
47NLK0.84306902
48MATK0.82754215
49PRPF4B0.81637960
50MAPK70.81057302
51MAP3K110.79270070
52EPHB10.78984441
53TGFBR20.78619212
54MAP3K30.77651340
55STK100.77459793
56TAOK10.76413162
57KDR0.75508110
58ADRBK20.74833793
59PDK10.65258887
60MAP3K10.65173820
61SIK30.62028556
62EPHA30.61216149
63MAPK120.59555157
64FYN0.58944027
65MAP2K60.58463018
66PIM10.58316444
67CAMKK10.58282382
68STK110.56404758
69IRAK20.55162908
70CDK190.54216587
71HIPK20.52638571
72ACVR1B0.50307484
73PRKD20.49551445
74INSRR0.49070042
75PINK10.45550587
76GRK10.45477512
77DAPK20.45216814
78GRK70.44364663
79MAP3K50.44125403
80SGK20.40690754
81RPS6KA60.40386992
82MAP2K40.40386862
83PRKG20.38455983
84MAPK130.38359406
85ADRBK10.38225082
86MARK20.37609138
87ABL10.37442799
88RAF10.36416959
89CDK40.36077024
90RET0.33975345
91RPS6KL10.33156672
92RPS6KC10.33156672
93SGK30.31599588
94IGF1R0.31222081
95PTK60.30970546
96LRRK20.30399512
97KSR20.29196324
98SIK20.28916546
99PDPK10.28617586
100EGFR0.28192191

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.27198496
2Graft-versus-host disease_Homo sapiens_hsa053323.10841426
3Allograft rejection_Homo sapiens_hsa053303.05211203
4Leishmaniasis_Homo sapiens_hsa051402.90808053
5Autoimmune thyroid disease_Homo sapiens_hsa053202.89802055
6Staphylococcus aureus infection_Homo sapiens_hsa051502.79691186
7Osteoclast differentiation_Homo sapiens_hsa043802.46995361
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.36241698
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35482843
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35418737
11Asthma_Homo sapiens_hsa053102.32330142
12Type I diabetes mellitus_Homo sapiens_hsa049402.26114668
13B cell receptor signaling pathway_Homo sapiens_hsa046622.21924237
14Hematopoietic cell lineage_Homo sapiens_hsa046402.11167257
15T cell receptor signaling pathway_Homo sapiens_hsa046602.03158786
16Antigen processing and presentation_Homo sapiens_hsa046121.98706763
17Tuberculosis_Homo sapiens_hsa051521.89895406
18Measles_Homo sapiens_hsa051621.85248539
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.82470834
20* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78098466
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70546667
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65630119
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62124367
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59134882
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.55785093
26Viral myocarditis_Homo sapiens_hsa054161.51494753
27Platelet activation_Homo sapiens_hsa046111.51237456
28Chemokine signaling pathway_Homo sapiens_hsa040621.50613947
29Malaria_Homo sapiens_hsa051441.48746905
30Toxoplasmosis_Homo sapiens_hsa051451.40924708
31Herpes simplex infection_Homo sapiens_hsa051681.39193927
32Influenza A_Homo sapiens_hsa051641.37588451
33Rheumatoid arthritis_Homo sapiens_hsa053231.19452656
34Acute myeloid leukemia_Homo sapiens_hsa052211.15336614
35TNF signaling pathway_Homo sapiens_hsa046681.14112214
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13144596
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11853940
38Legionellosis_Homo sapiens_hsa051341.10719321
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06264117
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05563712
41African trypanosomiasis_Homo sapiens_hsa051431.03982545
42Phagosome_Homo sapiens_hsa041450.97392774
43Hepatitis B_Homo sapiens_hsa051610.95702827
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.94378986
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87732288
46Dorso-ventral axis formation_Homo sapiens_hsa043200.86755543
47Pertussis_Homo sapiens_hsa051330.86505905
48Non-small cell lung cancer_Homo sapiens_hsa052230.81937181
49Hepatitis C_Homo sapiens_hsa051600.79820411
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77402181
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77258821
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76401131
53Other glycan degradation_Homo sapiens_hsa005110.67890016
54Prolactin signaling pathway_Homo sapiens_hsa049170.67273283
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66898773
56Linoleic acid metabolism_Homo sapiens_hsa005910.65453740
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65083372
58Apoptosis_Homo sapiens_hsa042100.64575325
59Regulation of autophagy_Homo sapiens_hsa041400.61883002
60Pancreatic cancer_Homo sapiens_hsa052120.60924871
61Arachidonic acid metabolism_Homo sapiens_hsa005900.59114044
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57582827
63Epstein-Barr virus infection_Homo sapiens_hsa051690.56357261
64VEGF signaling pathway_Homo sapiens_hsa043700.55412771
65Shigellosis_Homo sapiens_hsa051310.55124022
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53972439
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53926241
68FoxO signaling pathway_Homo sapiens_hsa040680.53349970
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.48835433
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.48354500
71HTLV-I infection_Homo sapiens_hsa051660.47516007
72Viral carcinogenesis_Homo sapiens_hsa052030.47485836
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46365439
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.46055538
75Ether lipid metabolism_Homo sapiens_hsa005650.42603896
76Choline metabolism in cancer_Homo sapiens_hsa052310.42558220
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.42319867
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.42093100
79Chronic myeloid leukemia_Homo sapiens_hsa052200.41233107
80Salmonella infection_Homo sapiens_hsa051320.40492600
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40128421
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39919867
83Inositol phosphate metabolism_Homo sapiens_hsa005620.39421925
84mTOR signaling pathway_Homo sapiens_hsa041500.38622384
85Lysosome_Homo sapiens_hsa041420.38499223
86Endocytosis_Homo sapiens_hsa041440.36714532
87Insulin resistance_Homo sapiens_hsa049310.36631112
88MAPK signaling pathway_Homo sapiens_hsa040100.36607811
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36402338
90Systemic lupus erythematosus_Homo sapiens_hsa053220.35219194
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30482246
92Olfactory transduction_Homo sapiens_hsa047400.30073089
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.30069158
94Renin secretion_Homo sapiens_hsa049240.30053039
95Ras signaling pathway_Homo sapiens_hsa040140.28742403
96Type II diabetes mellitus_Homo sapiens_hsa049300.28345974
97Notch signaling pathway_Homo sapiens_hsa043300.27441508
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.26482481
99ABC transporters_Homo sapiens_hsa020100.26412061
100Renal cell carcinoma_Homo sapiens_hsa052110.25228568

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