CARM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.31466543
2DNA unwinding involved in DNA replication (GO:0006268)4.76663711
3paraxial mesoderm development (GO:0048339)4.55279014
4heterochromatin organization (GO:0070828)4.43998514
5regulation of translational fidelity (GO:0006450)4.33824296
6regulation of posttranscriptional gene silencing (GO:0060147)4.29632081
7regulation of gene silencing by miRNA (GO:0060964)4.29632081
8regulation of gene silencing by RNA (GO:0060966)4.29632081
9nuclear pore organization (GO:0006999)4.17620855
10nuclear pore complex assembly (GO:0051292)4.07096353
11regulation of mammary gland epithelial cell proliferation (GO:0033599)3.84846460
12protein localization to kinetochore (GO:0034501)3.81984908
13regulation of early endosome to late endosome transport (GO:2000641)3.81637634
14Golgi transport vesicle coating (GO:0048200)3.80204628
15COPI coating of Golgi vesicle (GO:0048205)3.80204628
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.79327374
17proline biosynthetic process (GO:0006561)3.67730406
18mitotic nuclear envelope disassembly (GO:0007077)3.63325060
19folic acid-containing compound biosynthetic process (GO:0009396)3.61530446
20polarized epithelial cell differentiation (GO:0030859)3.58875431
21IMP biosynthetic process (GO:0006188)3.55044083
22protein complex localization (GO:0031503)3.50229722
23regulation of hippo signaling (GO:0035330)3.46399565
24membrane disassembly (GO:0030397)3.44924064
25nuclear envelope disassembly (GO:0051081)3.44924064
26regulation of translational termination (GO:0006449)3.43636473
27chromosome condensation (GO:0030261)3.42764959
28protein retention in ER lumen (GO:0006621)3.38375600
29establishment of apical/basal cell polarity (GO:0035089)3.38028311
30protein localization to endosome (GO:0036010)3.36414873
31glucocorticoid receptor signaling pathway (GO:0042921)3.34260129
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30464487
33RNA stabilization (GO:0043489)3.29472613
34mRNA stabilization (GO:0048255)3.29472613
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29147363
36negative regulation of histone methylation (GO:0031061)3.28278293
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.26652131
38NLS-bearing protein import into nucleus (GO:0006607)3.26491027
39cell-substrate junction assembly (GO:0007044)3.24930447
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.24450701
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23641611
42hippo signaling (GO:0035329)3.21753459
43cellular protein complex localization (GO:0034629)3.21726399
44DNA duplex unwinding (GO:0032508)3.21274574
45negative regulation of RNA splicing (GO:0033119)3.19412312
46DNA replication-dependent nucleosome organization (GO:0034723)3.18932303
47DNA replication-dependent nucleosome assembly (GO:0006335)3.18932303
48negative regulation of mRNA processing (GO:0050686)3.18908584
49DNA geometric change (GO:0032392)3.18243620
50positive regulation of SMAD protein import into nucleus (GO:0060391)3.17446482
51sister chromatid segregation (GO:0000819)3.16176161
52protein localization to chromosome, centromeric region (GO:0071459)3.14625361
53negative regulation of mRNA metabolic process (GO:1903312)3.11154540
54mitotic sister chromatid segregation (GO:0000070)3.10548630
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10016791
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.09463744
57apoptotic process involved in morphogenesis (GO:0060561)3.09280842
58activation of Rac GTPase activity (GO:0032863)3.06398219
59chromatin assembly (GO:0031497)3.06263634
60peptidyl-lysine dimethylation (GO:0018027)3.05609602
61IMP metabolic process (GO:0046040)3.04060486
62convergent extension (GO:0060026)3.02953066
63formation of translation preinitiation complex (GO:0001731)3.02725288
64mitotic sister chromatid cohesion (GO:0007064)3.00159542
65pentose-phosphate shunt (GO:0006098)2.99484862
66regulation of stem cell maintenance (GO:2000036)2.96901446
67negative regulation of cell size (GO:0045792)2.95299485
68maternal placenta development (GO:0001893)2.94445553
69stress fiber assembly (GO:0043149)2.94099301
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93797687
71regulation of glucose import in response to insulin stimulus (GO:2001273)2.92957173
72basement membrane organization (GO:0071711)2.92039551
73regulation of nucleobase-containing compound transport (GO:0032239)2.91728996
74regulation of RNA export from nucleus (GO:0046831)2.91054019
75regulation of SMAD protein import into nucleus (GO:0060390)2.90449886
76negative regulation of erythrocyte differentiation (GO:0045647)2.88426553
77regulation of sister chromatid cohesion (GO:0007063)2.88071788
78protein-DNA complex disassembly (GO:0032986)2.85790644
79nucleosome disassembly (GO:0006337)2.85790644
80establishment or maintenance of monopolar cell polarity (GO:0061339)2.85531448
81establishment of monopolar cell polarity (GO:0061162)2.85531448
82dosage compensation (GO:0007549)2.80666536
83anterior/posterior axis specification, embryo (GO:0008595)2.79778926
84regulation of histone H3-K27 methylation (GO:0061085)2.79752562
85positive regulation of myotube differentiation (GO:0010831)2.79714724
86DNA packaging (GO:0006323)2.79131313
87nuclear envelope organization (GO:0006998)2.79123763
88modulation by symbiont of host cellular process (GO:0044068)2.77800860
893-UTR-mediated mRNA stabilization (GO:0070935)2.76731096
90regulation of spindle organization (GO:0090224)2.76593148
91mitotic chromosome condensation (GO:0007076)2.75811776
92glucose 6-phosphate metabolic process (GO:0051156)2.75216200
93regulation of mitotic spindle organization (GO:0060236)2.75201187
94pore complex assembly (GO:0046931)2.75147543
95trophectodermal cell differentiation (GO:0001829)2.75044048
96positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.74276187
97epithelial cell-cell adhesion (GO:0090136)2.73814482
98embryonic process involved in female pregnancy (GO:0060136)2.73535912
99adherens junction assembly (GO:0034333)2.73429686
100histone H2A monoubiquitination (GO:0035518)2.72241250
101cellular response to epidermal growth factor stimulus (GO:0071364)2.71951805
102activation of MAPKKK activity (GO:0000185)2.71731766
103regulation of histone H3-K9 methylation (GO:0051570)2.69178410
104embryonic foregut morphogenesis (GO:0048617)2.67915903
105protein export from nucleus (GO:0006611)2.67187024
106* intracellular estrogen receptor signaling pathway (GO:0030520)2.66712482
107nodal signaling pathway (GO:0038092)2.64929682
108notochord development (GO:0030903)2.64355979
109positive regulation of RNA splicing (GO:0033120)2.63145366
110barbed-end actin filament capping (GO:0051016)2.62794588
111negative regulation of DNA repair (GO:0045738)2.62507456
112regulation of mRNA stability (GO:0043488)2.62216543
113positive regulation of chromosome segregation (GO:0051984)2.60591247
114semaphorin-plexin signaling pathway (GO:0071526)2.60275533
115pinocytosis (GO:0006907)2.58643398
116regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.58243673
117cochlea morphogenesis (GO:0090103)2.57981248
118modulation by virus of host process (GO:0019054)2.57613024
119nucleobase biosynthetic process (GO:0046112)2.55900813
120cellular hyperosmotic response (GO:0071474)2.55301158
121NADPH regeneration (GO:0006740)2.55038080
122DNA replication initiation (GO:0006270)2.54866082
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54309316
124regulation of gene silencing (GO:0060968)2.53691092
125establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52231634
126regulation of NFAT protein import into nucleus (GO:0051532)2.51540748
127regulation of chromatin binding (GO:0035561)2.51486199
128* peptidyl-arginine omega-N-methylation (GO:0035247)2.51378493
129histone H4-K12 acetylation (GO:0043983)2.51302278
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51062682
131corticosteroid receptor signaling pathway (GO:0031958)2.51001705
132mitotic G1 DNA damage checkpoint (GO:0031571)2.50432918
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50177081
134skin morphogenesis (GO:0043589)2.49644067
135modulation by virus of host morphology or physiology (GO:0019048)2.46152105
136positive regulation of nuclease activity (GO:0032075)2.45965487
137DNA strand elongation involved in DNA replication (GO:0006271)2.45898785
138apoptotic process involved in development (GO:1902742)2.45294068
139chromatin silencing (GO:0006342)2.45056111
140glucose catabolic process (GO:0006007)2.44859225
141DNA conformation change (GO:0071103)2.44487200
142alternative mRNA splicing, via spliceosome (GO:0000380)2.44264701
143positive regulation of Cdc42 GTPase activity (GO:0043089)2.43912542
144negative regulation of skeletal muscle tissue development (GO:0048642)2.43599291
145regulation of RNA stability (GO:0043487)2.43233321
146positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43155491
147G1 DNA damage checkpoint (GO:0044783)2.43092126
148intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.43031975
149plasma membrane repair (GO:0001778)2.42930401
150cell-substrate adherens junction assembly (GO:0007045)2.42665964
151focal adhesion assembly (GO:0048041)2.42665964
152mRNA transport (GO:0051028)2.42659313
153glycolytic process (GO:0006096)2.39237272
154negative regulation of viral release from host cell (GO:1902187)2.36100230
155regulation of establishment of planar polarity (GO:0090175)2.35768872
156proline metabolic process (GO:0006560)2.35725423
157regulation of cholesterol homeostasis (GO:2000188)2.34611563
158mitotic G1/S transition checkpoint (GO:0044819)2.34512496
159cellular response to virus (GO:0098586)2.33073967
160protein localization to microtubule (GO:0035372)2.33064782
161trophoblast giant cell differentiation (GO:0060707)2.31539590
162positive regulation of gene expression, epigenetic (GO:0045815)2.29740506
163negative regulation of striated muscle cell differentiation (GO:0051154)2.28207003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.88950584
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.67598730
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21759454
4MYC_22102868_ChIP-Seq_BL_Human3.19955774
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.14707223
6* MYC_18555785_ChIP-Seq_MESCs_Mouse2.95705440
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75952943
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58782606
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.52108950
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46067201
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37156576
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25686301
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18441932
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06557025
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05582205
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99975626
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90883242
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89411168
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87199466
20AR_21909140_ChIP-Seq_LNCAP_Human1.87185078
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83529572
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79994998
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78730663
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77532129
25KDM2B_26808549_Chip-Seq_DND41_Human1.77405237
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.75173063
27VDR_21846776_ChIP-Seq_THP-1_Human1.74339633
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70122420
29XRN2_22483619_ChIP-Seq_HELA_Human1.69540594
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68961725
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.68837857
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66958522
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66482463
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66228331
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65224642
36TCF7_22412390_ChIP-Seq_EML_Mouse1.64158381
37ZNF263_19887448_ChIP-Seq_K562_Human1.61509429
38CIITA_25753668_ChIP-Seq_RAJI_Human1.61085318
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59558148
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56387615
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53783846
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53374189
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52551453
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52385040
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50804820
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48898041
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47803861
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.46839624
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45696272
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44842817
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44181247
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44156012
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43943687
54NANOG_21062744_ChIP-ChIP_HESCs_Human1.41852907
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41208304
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.40478323
57P68_20966046_ChIP-Seq_HELA_Human1.40379032
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39867255
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39525781
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39375419
61ATF3_27146783_Chip-Seq_COLON_Human1.38524512
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37216250
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36416545
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35667851
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35278995
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35275377
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.33253890
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32852147
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32169485
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32169485
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32169485
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31904417
73* LXR_22292898_ChIP-Seq_THP-1_Human1.30398065
74RACK7_27058665_Chip-Seq_MCF-7_Human1.30173235
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29677817
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.28643390
77* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28530125
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27683019
79MAF_26560356_Chip-Seq_TH1_Human1.27346560
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26842543
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26452901
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25916022
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25842318
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25547551
85SMC4_20622854_ChIP-Seq_HELA_Human1.24027995
86KDM5A_27292631_Chip-Seq_BREAST_Human1.21475802
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19713431
88CHD1_26751641_Chip-Seq_LNCaP_Human1.17638355
89* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17603432
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17422931
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16477783
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.15605486
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14650672
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14038809
95* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12955442
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12466674
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12224752
98VDR_24763502_ChIP-Seq_THP-1_Human1.11904446
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.11881699
100NCOR1_26117541_ChIP-Seq_K562_Human1.11577978
101CLOCK_20551151_ChIP-Seq_293T_Human1.11269539
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10547369
103CREB1_26743006_Chip-Seq_LNCaP_Human1.09500626
104TP53_22127205_ChIP-Seq_IMR90_Human1.08631913
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08448505
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08194099
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.07520966
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07483342
109MAF_26560356_Chip-Seq_TH2_Human1.07427682
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07313606
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06598819
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.06552986
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06478919
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05198375
115KDM2B_26808549_Chip-Seq_K562_Human1.04853421
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04252050
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04068606
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02784964
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01162801
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00573272
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00193221
122TTF2_22483619_ChIP-Seq_HELA_Human0.99803684
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99042122
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98919273
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98411860
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97900797
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.97817972
128UTX_26944678_Chip-Seq_JUKART_Human0.97610996
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97405636
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96955585
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96739644
132THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95415044
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94302872
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94073510
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93737004
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93677846
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.93206979
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.92655208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.71157818
2MP0005451_abnormal_body_composition3.61968194
3MP0010030_abnormal_orbit_morphology3.51572603
4MP0010352_gastrointestinal_tract_polyps3.11119386
5MP0003123_paternal_imprinting2.63603416
6MP0003111_abnormal_nucleus_morphology2.58164309
7MP0005076_abnormal_cell_differentiation2.53949516
8MP0004957_abnormal_blastocyst_morpholog2.32642765
9MP0009053_abnormal_anal_canal2.20357865
10MP0003077_abnormal_cell_cycle2.11888913
11MP0001730_embryonic_growth_arrest2.11583813
12MP0004233_abnormal_muscle_weight2.08785885
13MP0004858_abnormal_nervous_system2.08740711
14MP0000537_abnormal_urethra_morphology2.02167649
15MP0010094_abnormal_chromosome_stability1.99644362
16MP0002084_abnormal_developmental_patter1.97936599
17MP0001348_abnormal_lacrimal_gland1.93031388
18* MP0004197_abnormal_fetal_growth/weight/1.92072907
19MP0003283_abnormal_digestive_organ1.90768781
20MP0001672_abnormal_embryogenesis/_devel1.89959331
21MP0005380_embryogenesis_phenotype1.89959331
22MP0003984_embryonic_growth_retardation1.83752399
23MP0000350_abnormal_cell_proliferation1.83383895
24MP0003119_abnormal_digestive_system1.82524228
25MP0002085_abnormal_embryonic_tissue1.81807944
26MP0002088_abnormal_embryonic_growth/wei1.81340970
27MP0001697_abnormal_embryo_size1.77920855
28MP0005623_abnormal_meninges_morphology1.75792901
29MP0002254_reproductive_system_inflammat1.74248793
30MP0000678_abnormal_parathyroid_gland1.71677062
31MP0000733_abnormal_muscle_development1.71398299
32MP0002086_abnormal_extraembryonic_tissu1.70115176
33MP0003091_abnormal_cell_migration1.69122442
34MP0003693_abnormal_embryo_hatching1.66260179
35MP0003121_genomic_imprinting1.64492737
36MP0003567_abnormal_fetal_cardiomyocyte1.63795127
37MP0000428_abnormal_craniofacial_morphol1.63627950
38MP0003453_abnormal_keratinocyte_physiol1.63370447
39MP0008438_abnormal_cutaneous_collagen1.62203720
40MP0003122_maternal_imprinting1.61736049
41MP0003115_abnormal_respiratory_system1.60149075
42MP0002653_abnormal_ependyma_morphology1.57841600
43MP0003566_abnormal_cell_adhesion1.55242132
44MP0003890_abnormal_embryonic-extraembry1.53899520
45MP0009672_abnormal_birth_weight1.52491071
46MP0005058_abnormal_lysosome_morphology1.51013250
47MP0001849_ear_inflammation1.50487326
48* MP0002080_prenatal_lethality1.48523126
49MP0003385_abnormal_body_wall1.48237589
50MP0008057_abnormal_DNA_replication1.46685181
51MP0001293_anophthalmia1.46169786
52MP0008007_abnormal_cellular_replicative1.44174659
53MP0005666_abnormal_adipose_tissue1.40583060
54MP0002796_impaired_skin_barrier1.40446412
55MP0002249_abnormal_larynx_morphology1.39342037
56MP0010307_abnormal_tumor_latency1.37344989
57MP0008932_abnormal_embryonic_tissue1.36655353
58MP0005409_darkened_coat_color1.35561888
59MP0003303_peritoneal_inflammation1.35559862
60MP0009278_abnormal_bone_marrow1.33552942
61MP0008260_abnormal_autophagy1.31974349
62MP0003935_abnormal_craniofacial_develop1.30637197
63MP0009703_decreased_birth_body1.27727665
64MP0000049_abnormal_middle_ear1.27357380
65MP0010630_abnormal_cardiac_muscle1.26778003
66MP0002925_abnormal_cardiovascular_devel1.26446648
67MP0005501_abnormal_skin_physiology1.25055932
68MP0004510_myositis1.25021460
69MP0002932_abnormal_joint_morphology1.22632563
70MP0003941_abnormal_skin_development1.21623222
71MP0004087_abnormal_muscle_fiber1.21174819
72MP0003942_abnormal_urinary_system1.20142119
73MP0003300_gastrointestinal_ulcer1.18988498
74MP0000750_abnormal_muscle_regeneration1.18450179
75MP0005023_abnormal_wound_healing1.17047998
76MP0000534_abnormal_ureter_morphology1.16457439
77MP0002111_abnormal_tail_morphology1.16455361
78MP0002089_abnormal_postnatal_growth/wei1.14390423
79MP0003937_abnormal_limbs/digits/tail_de1.14075473
80MP0002060_abnormal_skin_morphology1.13536915
81MP0004272_abnormal_basement_membrane1.13344922
82MP0004133_heterotaxia1.13226507
83MP0003279_aneurysm1.13184006
84MP0000266_abnormal_heart_morphology1.12551794
85MP0000749_muscle_degeneration1.10766813
86MP0004084_abnormal_cardiac_muscle1.10525703
87MP0002269_muscular_atrophy1.09671051
88MP0003755_abnormal_palate_morphology1.09264584
89MP0006054_spinal_hemorrhage1.08401315
90MP0002396_abnormal_hematopoietic_system1.07198778
91MP0001346_abnormal_lacrimal_gland1.06678885
92MP0005503_abnormal_tendon_morphology1.05558095
93MP0000566_synostosis1.05021532
94MP0000751_myopathy1.04322648
95* MP0005375_adipose_tissue_phenotype1.03718583
96MP0000858_altered_metastatic_potential1.03305479
97MP0002234_abnormal_pharynx_morphology1.03023508
98MP0000432_abnormal_head_morphology1.02620123
99MP0005275_abnormal_skin_tensile1.02252635
100MP0002697_abnormal_eye_size1.02140349
101MP0005621_abnormal_cell_physiology1.01720718
102MP0002092_abnormal_eye_morphology0.99586267
103MP0009840_abnormal_foam_cell0.98680478
104MP0001915_intracranial_hemorrhage0.98589833
105MP0000767_abnormal_smooth_muscle0.98084241
106MP0009780_abnormal_chondrocyte_physiolo0.97735487
107MP0008770_decreased_survivor_rate0.95828230
108MP0002877_abnormal_melanocyte_morpholog0.95400248
109MP0004264_abnormal_extraembryonic_tissu0.95219209
110MP0000759_abnormal_skeletal_muscle0.94164398
111MP0002116_abnormal_craniofacial_bone0.93780851
112MP0004185_abnormal_adipocyte_glucose0.93163690
113MP0003861_abnormal_nervous_system0.92656228
114MP0005508_abnormal_skeleton_morphology0.91405450
115MP0005187_abnormal_penis_morphology0.91352306
116MP0004808_abnormal_hematopoietic_stem0.90673803
117MP0002106_abnormal_muscle_physiology0.90280890
118MP0002282_abnormal_trachea_morphology0.90024674
119MP0005257_abnormal_intraocular_pressure0.87799493
120MP0002114_abnormal_axial_skeleton0.86981936
121MP0004947_skin_inflammation0.84679004
122MP0009250_abnormal_appendicular_skeleto0.84440944
123MP0000747_muscle_weakness0.84301003
124MP0008961_abnormal_basal_metabolism0.83984724
125MP0010234_abnormal_vibrissa_follicle0.83678702
126* MP0000003_abnormal_adipose_tissue0.81918523
127MP0001661_extended_life_span0.79221314
128MP0000490_abnormal_crypts_of0.78645309
129MP0005369_muscle_phenotype0.78095524
130MP0005330_cardiomyopathy0.77821505
131MP0000313_abnormal_cell_death0.77462438
132MP0000762_abnormal_tongue_morphology0.76942637
133MP0009931_abnormal_skin_appearance0.73613985
134MP0002108_abnormal_muscle_morphology0.73312789
135MP0005670_abnormal_white_adipose0.72599084
136MP0001299_abnormal_eye_distance/0.71508444
137MP0003221_abnormal_cardiomyocyte_apopto0.70357870

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.83261671
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76661033
3Short 4th metacarpal (HP:0010044)3.76661033
4Shallow orbits (HP:0000586)3.37871672
5Centrally nucleated skeletal muscle fibers (HP:0003687)3.25344321
6Ependymoma (HP:0002888)3.16002412
7Renal duplication (HP:0000075)3.15355648
8Abnormality of the 4th metacarpal (HP:0010012)3.12063193
9Distal lower limb amyotrophy (HP:0008944)3.05431923
10Myopathic facies (HP:0002058)3.01985661
11Selective tooth agenesis (HP:0001592)2.87828282
12Hyperacusis (HP:0010780)2.82164600
13Increased nuchal translucency (HP:0010880)2.75698464
14Abnormality of skeletal muscle fiber size (HP:0012084)2.72702541
15Increased variability in muscle fiber diameter (HP:0003557)2.70678046
16Distal lower limb muscle weakness (HP:0009053)2.66914832
17Spinal rigidity (HP:0003306)2.64041889
18Astrocytoma (HP:0009592)2.62262674
19Abnormality of the astrocytes (HP:0100707)2.62262674
20Muscle fiber inclusion bodies (HP:0100299)2.60458138
21Exercise-induced myalgia (HP:0003738)2.60079857
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.58797305
23Nemaline bodies (HP:0003798)2.55424367
24Disproportionate tall stature (HP:0001519)2.53003574
25Ankle contracture (HP:0006466)2.47488976
26Lower limb amyotrophy (HP:0007210)2.47447727
27Cerebral aneurysm (HP:0004944)2.38996297
28Genu recurvatum (HP:0002816)2.38118008
29Round ear (HP:0100830)2.36640538
30Asymmetry of the thorax (HP:0001555)2.36513355
31Abnormality of the Achilles tendon (HP:0005109)2.35032799
32Broad thumb (HP:0011304)2.32724690
33Long palpebral fissure (HP:0000637)2.31979760
34Mildly elevated creatine phosphokinase (HP:0008180)2.30472893
35Deviation of the thumb (HP:0009603)2.23375716
36Bowel diverticulosis (HP:0005222)2.21922100
37Trigonocephaly (HP:0000243)2.20214866
38Increased connective tissue (HP:0009025)2.18844826
39Proximal placement of thumb (HP:0009623)2.17468815
40Bladder diverticulum (HP:0000015)2.17129396
41Deviation of the hallux (HP:0010051)2.16784289
42Colon cancer (HP:0003003)2.15342042
43Thin ribs (HP:0000883)2.14959227
44Broad face (HP:0000283)2.14604087
45Progressive muscle weakness (HP:0003323)2.14601703
46Abnormal number of incisors (HP:0011064)2.14486506
47Dysmetric saccades (HP:0000641)2.12952108
48Medulloblastoma (HP:0002885)2.12523593
49Hallux valgus (HP:0001822)2.11123913
50Premature rupture of membranes (HP:0001788)2.09058760
51Skin tags (HP:0010609)2.08048005
52Broad palm (HP:0001169)2.06903346
53Renovascular hypertension (HP:0100817)2.06181819
54Calcaneovalgus deformity (HP:0001848)2.05625243
55Rib fusion (HP:0000902)2.05609129
56Vertebral compression fractures (HP:0002953)2.04246187
57Obstructive sleep apnea (HP:0002870)2.03664586
58Cholecystitis (HP:0001082)2.03257105
59Abnormal gallbladder physiology (HP:0012438)2.03257105
60Heterotopia (HP:0002282)2.02976105
61Fragile skin (HP:0001030)2.02500517
62Atresia of the external auditory canal (HP:0000413)2.02476862
63Long eyelashes (HP:0000527)2.02352819
64Abnormality of the lower motor neuron (HP:0002366)2.01442600
65Insomnia (HP:0100785)2.00260430
66Glioma (HP:0009733)1.99988879
67Neoplasm of the oral cavity (HP:0100649)1.99884994
68Neoplasm of striated muscle (HP:0009728)1.99743301
69Difficulty climbing stairs (HP:0003551)1.99082736
70Biconcave vertebral bodies (HP:0004586)1.98606235
71Mitral valve prolapse (HP:0001634)1.97689939
72Broad phalanges of the hand (HP:0009768)1.96873985
73Elfin facies (HP:0004428)1.96119121
74Lymphangioma (HP:0100764)1.95566784
75Rectal prolapse (HP:0002035)1.94228327
76Broad toe (HP:0001837)1.92775725
77Skull defect (HP:0001362)1.92369011
78Missing ribs (HP:0000921)1.91774223
79Fibroma (HP:0010614)1.91619368
80Ulnar deviation of the wrist (HP:0003049)1.89137069
81Neonatal short-limb short stature (HP:0008921)1.88784184
82Fibrous tissue neoplasm (HP:0012316)1.87587681
83Pseudobulbar signs (HP:0002200)1.87528098
84Supernumerary ribs (HP:0005815)1.86212962
85Stridor (HP:0010307)1.85884614
86Gastrointestinal carcinoma (HP:0002672)1.85787990
87Malignant gastrointestinal tract tumors (HP:0006749)1.85787990
88Preauricular skin tag (HP:0000384)1.85164035
89Pointed chin (HP:0000307)1.85050413
90Arnold-Chiari malformation (HP:0002308)1.84828965
91Slender build (HP:0001533)1.84021303
92Short 5th finger (HP:0009237)1.83878868
93Generalized amyotrophy (HP:0003700)1.83780364
94Upper limb amyotrophy (HP:0009129)1.83533556
95Distal upper limb amyotrophy (HP:0007149)1.83533556
96Abnormality of the calcaneus (HP:0008364)1.83448618
97Angiofibromas (HP:0010615)1.83387069
98Adenoma sebaceum (HP:0009720)1.83387069
99Flat acetabular roof (HP:0003180)1.82504318
100Increased density of long bones (HP:0006392)1.80825372
101Back pain (HP:0003418)1.80748400
102Short phalanx of the thumb (HP:0009660)1.80175029
103Flat cornea (HP:0007720)1.80057005
104Broad finger (HP:0001500)1.79633000
105Broad metatarsal (HP:0001783)1.79381253
106Ulnar bowing (HP:0003031)1.79226609
107Advanced eruption of teeth (HP:0006288)1.77972019
108Premature skin wrinkling (HP:0100678)1.77217572
109Blue sclerae (HP:0000592)1.76331787
110Overriding aorta (HP:0002623)1.76193881
111Deformed tarsal bones (HP:0008119)1.74721894
112Mitral regurgitation (HP:0001653)1.74274486
113Reticulocytosis (HP:0001923)1.73858214
114Aneurysm (HP:0002617)1.73681869
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.73317775
116Megalocornea (HP:0000485)1.73278168
117Coronal craniosynostosis (HP:0004440)1.73113233
118Patellar dislocation (HP:0002999)1.72819992
119High pitched voice (HP:0001620)1.72750434
120Wrist flexion contracture (HP:0001239)1.72026215
121Broad long bones (HP:0005622)1.71469981
122Urethral obstruction (HP:0000796)1.71359653
123Short humerus (HP:0005792)1.70943839
124Ankyloglossia (HP:0010296)1.70739070
125Exercise-induced muscle cramps (HP:0003710)1.70623469
126Broad hallux (HP:0010055)1.70470884
127Type 1 muscle fiber predominance (HP:0003803)1.70373298
128Thin bony cortex (HP:0002753)1.70251281
129Asymmetric septal hypertrophy (HP:0001670)1.69088410
130Broad phalanx (HP:0006009)1.68795982
131Neoplasm of the heart (HP:0100544)1.68497279
132Dilatation of the ascending aorta (HP:0005111)1.67864743
133Basal cell carcinoma (HP:0002671)1.67709441
134Abnormality of the labia minora (HP:0012880)1.67313314
135Achilles tendon contracture (HP:0001771)1.66633214
136Enlarged penis (HP:0000040)1.66027997
137Elbow flexion contracture (HP:0002987)1.66014318
138Atrophic scars (HP:0001075)1.65842778
139Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.65808656
140Supernumerary bones of the axial skeleton (HP:0009144)1.65804796
141Rhabdomyosarcoma (HP:0002859)1.65070799
142Turricephaly (HP:0000262)1.64981411
143Hand muscle atrophy (HP:0009130)1.64769648
144Vertebral fusion (HP:0002948)1.64494764
145Abnormality of the thoracic spine (HP:0100711)1.64283425
146Bowel incontinence (HP:0002607)1.63984188
147Trismus (HP:0000211)1.63927059
148Wormian bones (HP:0002645)1.63123545
149Cervical subluxation (HP:0003308)1.62508523
150Macroorchidism (HP:0000053)1.61592571
151Intestinal polyp (HP:0005266)1.61542970
152Aplasia/hypoplasia of the humerus (HP:0006507)1.61370638
153Abnormality of the diencephalon (HP:0010662)1.60932425
154Natal tooth (HP:0000695)1.58574778
155Breech presentation (HP:0001623)1.55562254
156Nonimmune hydrops fetalis (HP:0001790)1.54578790
157Hyperextensible skin (HP:0000974)1.53578920
158Syringomyelia (HP:0003396)1.52376501
159Spinal cord lesions (HP:0100561)1.52376501
160Abnormal large intestine physiology (HP:0012700)1.52308716
161Persistence of primary teeth (HP:0006335)1.51626443
162Abnormality of oral frenula (HP:0000190)1.51298375
163Abnormality of dentin (HP:0010299)1.49574725
164Congenital hip dislocation (HP:0001374)1.49334943
165Midface retrusion (HP:0011800)1.47933908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.13014177
2CDK123.83503812
3TRIB33.61062626
4PKN23.50425004
5EEF2K3.30874467
6MAP3K103.11478687
7PRPF4B3.07774144
8CDC72.86952510
9TTN2.43621176
10NEK12.35717208
11BRD42.30849042
12ICK2.30233736
13LATS22.24174449
14IRAK32.20683999
15NEK22.16529397
16BUB12.01204939
17FGFR42.00752343
18LATS11.95411468
19PDGFRA1.88306365
20PRKD31.84345774
21MTOR1.65006588
22ALK1.61193071
23NME21.59262154
24TAOK21.59051522
25BMX1.46459853
26PAK41.41987929
27TTK1.37774002
28PTK61.34832040
29FGFR11.32797626
30TSSK61.32354262
31CDK41.30605776
32PASK1.29613514
33SCYL21.27038773
34RPS6KB21.25756918
35CDK71.23047965
36RIPK11.22233085
37MAP3K81.20931740
38DDR21.20869748
39MAP3K131.20131011
40ERN11.19159208
41CDK61.18623996
42SIK11.16282268
43WEE11.09302426
44PAK21.09084625
45RPS6KA41.07081322
46CHEK11.02739670
47MAP3K91.01631510
48TAOK10.99741619
49ARAF0.99489855
50DMPK0.99405447
51STK100.99245202
52EPHA20.98178311
53NTRK10.95652729
54ATR0.91574942
55TYRO30.90903789
56LRRK20.90537923
57PLK10.90447961
58BRAF0.86738128
59CAMK1D0.86379278
60CAMK1G0.84839013
61AKT20.83404808
62CDK20.82327310
63PTK20.80751441
64PDPK10.80185232
65AURKB0.75439550
66FLT30.75232862
67TGFBR10.75194451
68STK30.74945381
69MAPK110.73535787
70MAP3K10.71842697
71ILK0.71757090
72TESK20.69830249
73MAP3K70.69491822
74EPHB20.68925426
75CHEK20.67058278
76MAP2K30.66480234
77MOS0.66405033
78MKNK10.63928889
79MAP2K20.63649503
80ATM0.63024991
81PRKD20.61182001
82MARK20.61003967
83MST1R0.60609201
84MAP3K140.60300153
85TESK10.59552931
86PNCK0.58564334
87CSNK1E0.55100610
88STK40.54321651
89CDK10.53747617
90EPHB10.53741060
91RPS6KA10.52551571
92PRKG20.51299711
93PLK30.50616186
94DYRK30.49992757
95KSR20.49050580
96CDC42BPA0.48324858
97FGFR30.47831868
98CDK11A0.47666231
99PAK10.47467741
100MELK0.47156452
101CLK10.46901996
102AURKA0.46526985
103MAP3K30.46230732
104MAP3K110.46003175
105CSNK1D0.45303730
106HIPK20.45145274
107PDGFRB0.43683787
108CDK90.43296842
109LMTK20.41882850
110CDK150.41675117
111RPS6KC10.41378903
112RPS6KL10.41378903
113RET0.41320794
114PRKDC0.41276869
115MET0.41085033
116RPS6KA20.40748957
117MAPK10.40467534
118SIK20.39516415
119PAK60.38528874
120KDR0.38269688
121MAPK140.37773059
122DYRK1B0.37737408
123OBSCN0.37264856
124PDK10.37003668
125AKT10.36802255
126PHKG10.36537881
127PHKG20.36537881
128IRAK20.36139745
129CDK180.35204700
130MAPK90.35101369
131GSK3B0.34044810
132STK380.34003158
133MAPK100.32538628
134SGK30.32403033
135RPS6KA60.31540716
136ERBB20.31526530
137NEK90.31340004
138KSR10.31268402

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.71507622
2RNA transport_Homo sapiens_hsa030132.60127716
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42582998
4Spliceosome_Homo sapiens_hsa030402.30649947
5mRNA surveillance pathway_Homo sapiens_hsa030152.21640485
6Basal cell carcinoma_Homo sapiens_hsa052172.20263456
7Mismatch repair_Homo sapiens_hsa034302.18760136
8One carbon pool by folate_Homo sapiens_hsa006702.17330864
9Cell cycle_Homo sapiens_hsa041102.17206519
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15892667
11Hippo signaling pathway_Homo sapiens_hsa043901.86830505
12Pentose phosphate pathway_Homo sapiens_hsa000301.86647624
13Base excision repair_Homo sapiens_hsa034101.85760621
14Hedgehog signaling pathway_Homo sapiens_hsa043401.75321966
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71933264
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.69297321
17Adherens junction_Homo sapiens_hsa045201.67992798
18Bladder cancer_Homo sapiens_hsa052191.65561132
19MicroRNAs in cancer_Homo sapiens_hsa052061.65357548
20Notch signaling pathway_Homo sapiens_hsa043301.65350342
21mTOR signaling pathway_Homo sapiens_hsa041501.64421254
22Chronic myeloid leukemia_Homo sapiens_hsa052201.60464347
23Lysine degradation_Homo sapiens_hsa003101.54224195
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50646930
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48476421
26Fructose and mannose metabolism_Homo sapiens_hsa000511.47118379
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46473320
28Proteoglycans in cancer_Homo sapiens_hsa052051.40752219
29Thyroid cancer_Homo sapiens_hsa052161.39114872
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37179875
31Prion diseases_Homo sapiens_hsa050201.35870454
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35033572
33Other glycan degradation_Homo sapiens_hsa005111.34902461
34Biosynthesis of amino acids_Homo sapiens_hsa012301.33314462
35Small cell lung cancer_Homo sapiens_hsa052221.31475813
36HTLV-I infection_Homo sapiens_hsa051661.29108160
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27776724
38B cell receptor signaling pathway_Homo sapiens_hsa046621.25521034
39Oocyte meiosis_Homo sapiens_hsa041141.24993650
40Focal adhesion_Homo sapiens_hsa045101.21015260
41Colorectal cancer_Homo sapiens_hsa052101.19451518
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16579555
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15099813
44TGF-beta signaling pathway_Homo sapiens_hsa043501.14769031
45Wnt signaling pathway_Homo sapiens_hsa043101.14327329
46Viral carcinogenesis_Homo sapiens_hsa052031.14193190
47Galactose metabolism_Homo sapiens_hsa000521.13757103
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12851823
49Endometrial cancer_Homo sapiens_hsa052131.12557485
50Nucleotide excision repair_Homo sapiens_hsa034201.10937935
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09744474
52p53 signaling pathway_Homo sapiens_hsa041151.08402215
53Non-small cell lung cancer_Homo sapiens_hsa052231.05912813
54Tight junction_Homo sapiens_hsa045301.05549509
55Viral myocarditis_Homo sapiens_hsa054161.04974953
56Dilated cardiomyopathy_Homo sapiens_hsa054141.01593445
57Glioma_Homo sapiens_hsa052141.01464041
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98222578
59RNA degradation_Homo sapiens_hsa030180.97843339
60AMPK signaling pathway_Homo sapiens_hsa041520.95125967
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.92820526
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92518230
63Glucagon signaling pathway_Homo sapiens_hsa049220.92470767
64Acute myeloid leukemia_Homo sapiens_hsa052210.90859158
65Pathways in cancer_Homo sapiens_hsa052000.90226046
66HIF-1 signaling pathway_Homo sapiens_hsa040660.90067771
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90040099
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89427595
69Apoptosis_Homo sapiens_hsa042100.89170249
70Insulin resistance_Homo sapiens_hsa049310.87801956
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86862319
72Insulin signaling pathway_Homo sapiens_hsa049100.86622101
73ECM-receptor interaction_Homo sapiens_hsa045120.84910020
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82821479
75Prostate cancer_Homo sapiens_hsa052150.82443720
76VEGF signaling pathway_Homo sapiens_hsa043700.81964560
77Prolactin signaling pathway_Homo sapiens_hsa049170.79942992
78Sulfur relay system_Homo sapiens_hsa041220.79243306
79Carbon metabolism_Homo sapiens_hsa012000.79209741
80Renal cell carcinoma_Homo sapiens_hsa052110.78806957
81GnRH signaling pathway_Homo sapiens_hsa049120.78059725
82Shigellosis_Homo sapiens_hsa051310.78032139
83Melanogenesis_Homo sapiens_hsa049160.76598639
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.76519879
85Estrogen signaling pathway_Homo sapiens_hsa049150.76423761
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74587270
87Hepatitis C_Homo sapiens_hsa051600.73473097
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73041909
89Influenza A_Homo sapiens_hsa051640.72974046
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71357532
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70934912
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70909455
93Pancreatic cancer_Homo sapiens_hsa052120.70090885
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.68840294
95Long-term potentiation_Homo sapiens_hsa047200.68456503
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67818134
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67694281
98Melanoma_Homo sapiens_hsa052180.66359595
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64978084
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.64681747
101Dorso-ventral axis formation_Homo sapiens_hsa043200.63889361
102Inositol phosphate metabolism_Homo sapiens_hsa005620.63510451
103Homologous recombination_Homo sapiens_hsa034400.62422039
104Selenocompound metabolism_Homo sapiens_hsa004500.61443420
105Choline metabolism in cancer_Homo sapiens_hsa052310.60877989
106Epstein-Barr virus infection_Homo sapiens_hsa051690.60257209
107Rap1 signaling pathway_Homo sapiens_hsa040150.59859896
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59468702
109Herpes simplex infection_Homo sapiens_hsa051680.58095180
110Gap junction_Homo sapiens_hsa045400.57747456
111Endocytosis_Homo sapiens_hsa041440.57581371
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.57430075
113Toxoplasmosis_Homo sapiens_hsa051450.56598381
114TNF signaling pathway_Homo sapiens_hsa046680.53518658
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53376190
116Amoebiasis_Homo sapiens_hsa051460.51937355
117Nitrogen metabolism_Homo sapiens_hsa009100.51165668
118Hepatitis B_Homo sapiens_hsa051610.50538650
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47710462
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.47106999
121Systemic lupus erythematosus_Homo sapiens_hsa053220.46847388
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46806581
123FoxO signaling pathway_Homo sapiens_hsa040680.44514743
124MAPK signaling pathway_Homo sapiens_hsa040100.43483564
125Type II diabetes mellitus_Homo sapiens_hsa049300.43359441
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.42744933
127Fanconi anemia pathway_Homo sapiens_hsa034600.42215655
128ErbB signaling pathway_Homo sapiens_hsa040120.41857474
129Antigen processing and presentation_Homo sapiens_hsa046120.41698509

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