CARMIL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.41845259
2negative thymic T cell selection (GO:0045060)5.99291647
3negative T cell selection (GO:0043383)5.89148162
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.74382078
5negative regulation of cell killing (GO:0031342)5.63360780
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.63360780
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.51496635
8positive thymic T cell selection (GO:0045059)5.50170319
9antigen processing and presentation of endogenous antigen (GO:0019883)5.49881842
10thymic T cell selection (GO:0045061)5.44754736
11regulation of B cell receptor signaling pathway (GO:0050855)5.32381187
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.25679356
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.22632488
14positive T cell selection (GO:0043368)5.00998654
15B cell receptor signaling pathway (GO:0050853)4.97543570
16T cell selection (GO:0045058)4.94919662
17regulation of gamma-delta T cell differentiation (GO:0045586)4.86441691
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82289159
19regulation of gamma-delta T cell activation (GO:0046643)4.80393018
20response to interleukin-15 (GO:0070672)4.68266113
21leukocyte aggregation (GO:0070486)4.56630684
22tolerance induction (GO:0002507)4.40831278
23T cell migration (GO:0072678)4.39311995
24positive regulation of granulocyte differentiation (GO:0030854)4.25531031
25negative regulation of erythrocyte differentiation (GO:0045647)4.22395406
26positive regulation of B cell differentiation (GO:0045579)4.18144529
27cellular response to interleukin-15 (GO:0071350)4.15078352
28regulation of B cell differentiation (GO:0045577)4.15009283
29mucosal-associated lymphoid tissue development (GO:0048537)4.00666091
30Peyers patch development (GO:0048541)4.00666091
31regulation of interleukin-2 biosynthetic process (GO:0045076)3.91474762
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.90822587
33CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.88060457
34regulation of alpha-beta T cell proliferation (GO:0046640)3.74776472
35negative regulation of T cell mediated immunity (GO:0002710)3.70246346
36NIK/NF-kappaB signaling (GO:0038061)3.65535506
37B cell homeostasis (GO:0001782)3.63007987
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.58926740
39antigen receptor-mediated signaling pathway (GO:0050851)3.57609681
40T cell homeostasis (GO:0043029)3.51529620
41detection of bacterium (GO:0016045)3.48801350
42germinal center formation (GO:0002467)3.45925945
43natural killer cell differentiation (GO:0001779)3.43338577
44response to muramyl dipeptide (GO:0032495)3.42179890
45positive regulation by symbiont of host defense response (GO:0052509)3.40605879
46modulation by symbiont of host defense response (GO:0052031)3.40605879
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40605879
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40605879
49positive regulation by organism of defense response of other organism involved in symbiotic interact3.40605879
50modulation by symbiont of host immune response (GO:0052553)3.40605879
51regulation of T cell tolerance induction (GO:0002664)3.39898057
52regulation of isotype switching to IgG isotypes (GO:0048302)3.35875129
53lymphocyte homeostasis (GO:0002260)3.31924810
54negative regulation of leukocyte mediated immunity (GO:0002704)3.28812097
55negative regulation of phagocytosis (GO:0050765)3.27162203
56detection of other organism (GO:0098543)3.26565134
57activated T cell proliferation (GO:0050798)3.26289027
58positive regulation of Rap GTPase activity (GO:0032854)3.25531772
59positive regulation of alpha-beta T cell proliferation (GO:0046641)3.23690232
60T cell receptor signaling pathway (GO:0050852)3.22651870
61positive regulation of interleukin-2 production (GO:0032743)3.21916657
62type I interferon signaling pathway (GO:0060337)3.19733097
63cellular response to type I interferon (GO:0071357)3.19733097
64response to type I interferon (GO:0034340)3.19717625
65T cell costimulation (GO:0031295)3.18631049
66lymphocyte costimulation (GO:0031294)3.15372720
67defense response to protozoan (GO:0042832)3.12847305
68regulation of granulocyte differentiation (GO:0030852)3.11773775
69cellular response to interleukin-4 (GO:0071353)3.09773495
70regulation of histone H3-K27 methylation (GO:0061085)3.09318000
71signal complex assembly (GO:0007172)3.08331050
72histone H3-K36 demethylation (GO:0070544)3.07621398
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03909529
74immunoglobulin mediated immune response (GO:0016064)3.03032901
75interferon-gamma production (GO:0032609)3.02533976
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00649696
77regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00491820
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98271787
79regulation of natural killer cell mediated immunity (GO:0002715)2.98271787
80regulation of interleukin-4 production (GO:0032673)2.97311362
81regulation of alpha-beta T cell activation (GO:0046634)2.95818295
82positive regulation of interleukin-4 production (GO:0032753)2.93571695
83response to protozoan (GO:0001562)2.92300536
84leukocyte homeostasis (GO:0001776)2.92078043
85regulation of tolerance induction (GO:0002643)2.89775026
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89026638
87positive regulation of isotype switching (GO:0045830)2.88669867
88B cell proliferation (GO:0042100)2.88198112
89positive regulation of B cell activation (GO:0050871)2.86171859
90interferon-gamma-mediated signaling pathway (GO:0060333)2.84411664
91response to interleukin-4 (GO:0070670)2.84302256
92mast cell activation (GO:0045576)2.83343822
93regulation of interferon-beta biosynthetic process (GO:0045357)2.83129772
94T cell lineage commitment (GO:0002360)2.81709672
95myeloid dendritic cell activation (GO:0001773)2.80155000
96antigen processing and presentation via MHC class Ib (GO:0002475)2.78409435
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78205946
98negative regulation of T-helper cell differentiation (GO:0045623)2.78205946
99myeloid dendritic cell differentiation (GO:0043011)2.75939658
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.74532866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.78178542
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01788469
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.91545827
4VDR_21846776_ChIP-Seq_THP-1_Human3.56922508
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38357799
6MAF_26560356_Chip-Seq_TH1_Human2.94954983
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79903681
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.70022863
9UTX_26944678_Chip-Seq_JUKART_Human2.68654284
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.63804920
11TCF7_22412390_ChIP-Seq_EML_Mouse2.60656618
12MYB_26560356_Chip-Seq_TH2_Human2.59423968
13RUNX_20019798_ChIP-Seq_JUKART_Human2.56639884
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55231554
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.55107406
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53943165
17MAF_26560356_Chip-Seq_TH2_Human2.49995759
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.45504976
19KDM2B_26808549_Chip-Seq_DND41_Human2.42430998
20MYB_26560356_Chip-Seq_TH1_Human2.38401802
21VDR_24763502_ChIP-Seq_THP-1_Human2.37097703
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24939142
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24405184
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15534813
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13243713
26CIITA_25753668_ChIP-Seq_RAJI_Human2.12805705
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10022209
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.04625196
29E2F7_22180533_ChIP-Seq_HELA_Human2.02497467
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02259135
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01776176
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98927429
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94028854
34SCL_19346495_ChIP-Seq_HPC-7_Human1.93923888
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91281761
36LXR_22292898_ChIP-Seq_THP-1_Human1.91153131
37SPI1_23547873_ChIP-Seq_NB4_Human1.83337417
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81890095
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.81698045
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74960061
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.74254568
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73885282
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70901993
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68037016
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.67942541
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.64535208
47GATA3_27048872_Chip-Seq_THYMUS_Human1.58241030
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56813704
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56266478
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51988757
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51711215
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.50908955
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50458387
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47262541
55SPI1_23127762_ChIP-Seq_K562_Human1.45870016
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41481502
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41429077
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40739288
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38282295
60P68_20966046_ChIP-Seq_HELA_Human1.32250223
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28901857
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28613310
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.28004009
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27779099
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27407846
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25664694
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24113599
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23438161
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22574393
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21648111
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.21316279
72BCOR_27268052_Chip-Seq_Bcells_Human1.20238389
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.19446897
74NCOR1_26117541_ChIP-Seq_K562_Human1.16764256
75BCL6_27268052_Chip-Seq_Bcells_Human1.11992423
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11266821
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10165187
78RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01916070
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01395000
80SMC4_20622854_ChIP-Seq_HELA_Human1.01006795
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00819427
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.00188969
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.99449837
84RACK7_27058665_Chip-Seq_MCF-7_Human0.99320231
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98598097
86KDM2B_26808549_Chip-Seq_K562_Human0.97225055
87CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96836111
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96789467
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95320175
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94505816
91ETS1_21867929_ChIP-Seq_TH2_Mouse0.92466646
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92341151
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90509662
94SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.90470754
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90118174
96ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89820613
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89109497
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.88589479
99GATA3_26560356_Chip-Seq_TH2_Human0.88451535
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87657627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.78902120
2MP0001835_abnormal_antigen_presentation3.61689269
3MP0003436_decreased_susceptibility_to3.55544098
4MP0005671_abnormal_response_to3.49036318
5MP0001800_abnormal_humoral_immune3.48776872
6MP0000685_abnormal_immune_system3.35847533
7MP0001790_abnormal_immune_system3.21642396
8MP0005387_immune_system_phenotype3.21642396
9MP0005000_abnormal_immune_tolerance3.07154721
10MP0003303_peritoneal_inflammation2.98990809
11MP0002396_abnormal_hematopoietic_system2.86088484
12MP0002420_abnormal_adaptive_immunity2.73648358
13MP0002398_abnormal_bone_marrow2.73083946
14MP0002723_abnormal_immune_serum2.70716767
15MP0001819_abnormal_immune_cell2.68377191
16MP0009333_abnormal_splenocyte_physiolog2.63141406
17MP0002452_abnormal_antigen_presenting2.59133478
18MP0001873_stomach_inflammation2.58900543
19MP0000703_abnormal_thymus_morphology2.56832218
20MP0003300_gastrointestinal_ulcer2.38877968
21MP0005025_abnormal_response_to2.37429788
22MP0000716_abnormal_immune_system2.36019558
23MP0002405_respiratory_system_inflammati2.13101545
24MP0002722_abnormal_immune_system2.12493476
25MP0003724_increased_susceptibility_to2.12137656
26MP0000689_abnormal_spleen_morphology2.11282586
27MP0002419_abnormal_innate_immunity2.04537554
28MP0010155_abnormal_intestine_physiology1.95320023
29MP0002429_abnormal_blood_cell1.94154132
30MP0005310_abnormal_salivary_gland1.93114309
31MP0004947_skin_inflammation1.85833091
32MP0003866_abnormal_defecation1.82855361
33MP0008057_abnormal_DNA_replication1.79204611
34MP0009785_altered_susceptibility_to1.78005181
35MP0002166_altered_tumor_susceptibility1.77178759
36MP0002009_preneoplasia1.71648632
37MP0004381_abnormal_hair_follicle1.68439638
38MP0009278_abnormal_bone_marrow1.62594307
39MP0001348_abnormal_lacrimal_gland1.58755345
40MP0002148_abnormal_hypersensitivity_rea1.55471457
41MP0005464_abnormal_platelet_physiology1.50500696
42MP0001845_abnormal_inflammatory_respons1.48758241
43MP0004808_abnormal_hematopoietic_stem1.48123203
44MP0002138_abnormal_hepatobiliary_system1.38839400
45MP0005451_abnormal_body_composition1.37574975
46MP0003172_abnormal_lysosome_physiology1.36236243
47MP0000490_abnormal_crypts_of1.30711102
48MP0002006_tumorigenesis1.26173771
49MP0008260_abnormal_autophagy1.21029049
50MP0002933_joint_inflammation1.18471441
51MP0001533_abnormal_skeleton_physiology1.17327280
52MP0006082_CNS_inflammation1.15453825
53MP0000465_gastrointestinal_hemorrhage1.13252695
54MP0001851_eye_inflammation1.11774809
55MP0001853_heart_inflammation1.11203618
56MP0004510_myositis1.01207845
57MP0002019_abnormal_tumor_incidence1.00871479
58MP0005075_abnormal_melanosome_morpholog0.96396822
59MP0000858_altered_metastatic_potential0.95617564
60MP0008469_abnormal_protein_level0.95514623
61MP0003183_abnormal_peptide_metabolism0.94446093
62MP0002132_abnormal_respiratory_system0.91587298
63MP0008961_abnormal_basal_metabolism0.88614107
64MP0004185_abnormal_adipocyte_glucose0.87591818
65MP0001663_abnormal_digestive_system0.86204395
66MP0001986_abnormal_taste_sensitivity0.85635362
67MP0001545_abnormal_hematopoietic_system0.84246778
68MP0005397_hematopoietic_system_phenotyp0.84246778
69MP0005076_abnormal_cell_differentiation0.82734383
70MP0008569_lethality_at_weaning0.80120850
71MP0002998_abnormal_bone_remodeling0.77814111
72MP0004859_abnormal_synaptic_plasticity0.75019528
73MP0003111_abnormal_nucleus_morphology0.73071016
74MP0002163_abnormal_gland_morphology0.73022018
75MP0000313_abnormal_cell_death0.72571836
76MP0003077_abnormal_cell_cycle0.69487649
77MP0010094_abnormal_chromosome_stability0.69403453
78MP0002693_abnormal_pancreas_physiology0.66558278
79MP0003091_abnormal_cell_migration0.66331144
80MP0000350_abnormal_cell_proliferation0.65887529
81MP0003787_abnormal_imprinting0.64136660
82MP0008874_decreased_physiological_sensi0.64060750
83MP0003045_fibrosis0.63457198
84MP0005621_abnormal_cell_physiology0.58305082
85MP0001730_embryonic_growth_arrest0.57764617
86MP0003191_abnormal_cellular_cholesterol0.57568800
87MP0005166_decreased_susceptibility_to0.55651221
88MP0002254_reproductive_system_inflammat0.53287641
89MP0002083_premature_death0.53074274
90MP0005381_digestive/alimentary_phenotyp0.49383807
91MP0003693_abnormal_embryo_hatching0.48505976
92MP0009763_increased_sensitivity_to0.47569162
93MP0005666_abnormal_adipose_tissue0.47144475
94MP0000015_abnormal_ear_pigmentation0.45513370
95MP0003448_altered_tumor_morphology0.43713653
96MP0000477_abnormal_intestine_morphology0.42524421
97MP0009115_abnormal_fat_cell0.38820353
98MP0002277_abnormal_respiratory_mucosa0.38819266
99MP0005535_abnormal_body_temperature0.38754973
100MP0003221_abnormal_cardiomyocyte_apopto0.38423956

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)5.42518045
2Eczematoid dermatitis (HP:0000976)5.32600211
3Agammaglobulinemia (HP:0004432)4.85453677
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.76287571
5Gastrointestinal stroma tumor (HP:0100723)4.43808777
6Meningitis (HP:0001287)4.42384684
7Recurrent viral infections (HP:0004429)4.33513085
8Recurrent fungal infections (HP:0002841)4.21023286
9Lymphopenia (HP:0001888)4.10389417
10Increased IgE level (HP:0003212)3.96604109
11Abnormality of cells of the lymphoid lineage (HP:0012140)3.83838187
12IgM deficiency (HP:0002850)3.74292018
13Cellulitis (HP:0100658)3.73697239
14Colitis (HP:0002583)3.73476760
15T lymphocytopenia (HP:0005403)3.71742808
16Recurrent bacterial skin infections (HP:0005406)3.71218471
17Gastrointestinal inflammation (HP:0004386)3.70012088
18Vasculitis (HP:0002633)3.66720364
19Pustule (HP:0200039)3.66413447
20Mediastinal lymphadenopathy (HP:0100721)3.61390847
21Recurrent abscess formation (HP:0002722)3.55957011
22Inflammation of the large intestine (HP:0002037)3.52120765
23Abnormality of T cells (HP:0002843)3.51794999
24Chronic mucocutaneous candidiasis (HP:0002728)3.44723563
25Recurrent cutaneous fungal infections (HP:0011370)3.44723563
26Papilloma (HP:0012740)3.43525189
27Verrucae (HP:0200043)3.43525189
28Abnormality of the fingertips (HP:0001211)3.40616518
29Myositis (HP:0100614)3.39070773
30Encephalitis (HP:0002383)3.38935797
31Severe combined immunodeficiency (HP:0004430)3.38863245
32Abnormality of T cell number (HP:0011839)3.37949981
33Recurrent bronchitis (HP:0002837)3.26951484
34Elevated erythrocyte sedimentation rate (HP:0003565)3.26426889
35Papilledema (HP:0001085)3.24898623
36Obstructive lung disease (HP:0006536)3.16444435
37Chronic obstructive pulmonary disease (HP:0006510)3.16444435
38Abnormality of T cell physiology (HP:0011840)3.15279853
39Recurrent sinusitis (HP:0011108)3.12259881
40Stomatitis (HP:0010280)3.09283040
41Gastrointestinal infarctions (HP:0005244)3.07103690
42Abnormality of macrophages (HP:0004311)3.06954042
43Basal cell carcinoma (HP:0002671)3.04501975
44Autoimmune hemolytic anemia (HP:0001890)3.01845575
45Granulocytopenia (HP:0001913)2.96909675
46Recurrent skin infections (HP:0001581)2.90133039
47Combined immunodeficiency (HP:0005387)2.84544847
48Spontaneous hematomas (HP:0007420)2.84210496
49IgG deficiency (HP:0004315)2.82676138
50Optic neuritis (HP:0100653)2.82093872
51Retrobulbar optic neuritis (HP:0100654)2.82093872
52Emphysema (HP:0002097)2.80502703
53B lymphocytopenia (HP:0010976)2.77494240
54Prolonged bleeding time (HP:0003010)2.74818072
55Orchitis (HP:0100796)2.74730375
56Abnormality of B cell number (HP:0010975)2.74070620
57IgA deficiency (HP:0002720)2.71917601
58Chest pain (HP:0100749)2.66920167
59Slow saccadic eye movements (HP:0000514)2.65380646
60Lymphoma (HP:0002665)2.64978841
61Viral hepatitis (HP:0006562)2.62408358
62Increased IgM level (HP:0003496)2.62317549
63Osteomyelitis (HP:0002754)2.60091075
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51922213
65Pulmonary infiltrates (HP:0002113)2.45425524
66Restrictive lung disease (HP:0002091)2.42136578
67Sepsis (HP:0100806)2.41747246
68Hypochromic anemia (HP:0001931)2.39694842
69Chronic diarrhea (HP:0002028)2.38207492
70Hypoplasia of the thymus (HP:0000778)2.33227569
71Recurrent gram-negative bacterial infections (HP:0005420)2.31252369
72Chronic otitis media (HP:0000389)2.29796935
73Urticaria (HP:0001025)2.24537660
74Eosinophilia (HP:0001880)2.21480612
75Leukocytosis (HP:0001974)2.20102041
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.19180936
77Obstructive sleep apnea (HP:0002870)2.19037356
78Deep palmar crease (HP:0006191)2.17193270
79Epistaxis (HP:0000421)2.14642416
80Gingivitis (HP:0000230)2.12877840
81Hypergammaglobulinemia (HP:0010702)2.12733125
82Seborrheic dermatitis (HP:0001051)2.11619159
83Annular pancreas (HP:0001734)2.10105840
84Abnormality of eosinophils (HP:0001879)2.07117565
85Keratoconjunctivitis sicca (HP:0001097)2.06816168
86Recurrent lower respiratory tract infections (HP:0002783)2.04470041
87Recurrent otitis media (HP:0000403)2.02057734
88Teleangiectasia of the skin (HP:0100585)2.01647935
89Hemoptysis (HP:0002105)1.97705614
90Skin ulcer (HP:0200042)1.94832048
91Pulmonary embolism (HP:0002204)1.94565449
92Fatigue (HP:0012378)1.94233075
93Keratoconjunctivitis (HP:0001096)1.88898685
94Hepatitis (HP:0012115)1.88779586
95Recurrent pneumonia (HP:0006532)1.84944582
96Nasal polyposis (HP:0100582)1.83471378
97Acute hepatic failure (HP:0006554)1.81063466
98Abnormality of small intestinal villus morphology (HP:0011472)1.80813798
99Villous atrophy (HP:0011473)1.80813798
100Autoimmune thrombocytopenia (HP:0001973)1.80554360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.55956517
2PRPF4B4.47076317
3RIPK43.48000537
4MAP3K103.04776414
5SMG12.62304936
6MAP3K132.40844551
7TRIB32.20454245
8ERN12.19710779
9CDK122.11937727
10SIK22.09903262
11TYK22.08027208
12TNK22.07870065
13BTK1.89261185
14MAP3K141.87251119
15TXK1.87114712
16FES1.77026139
17PASK1.74332683
18FGFR41.73129160
19SIK31.72726359
20IRAK41.71391880
21SYK1.68033908
22ZAP701.58452076
23ITK1.57974864
24GRK61.53535578
25JAK31.51676371
26BLK1.48528869
27IKBKE1.40284193
28MAP2K31.36788099
29CAMKK11.35095216
30HCK1.30521545
31JAK11.27260373
32CSK1.25163376
33EEF2K1.22690415
34CDK41.22455282
35MARK21.21769766
36LCK1.18225336
37FGFR31.12163746
38SIK11.08847643
39HIPK21.06448735
40LYN1.04130403
41MAPK121.03716784
42NLK1.02609009
43TBK11.00870849
44MAPK110.99871376
45ICK0.99240626
46CSF1R0.97244359
47MAP3K70.93237751
48TAOK10.89134357
49BRD40.88760743
50CDC42BPA0.88483246
51PDK10.86936502
52PRKCQ0.86148176
53TEC0.85451056
54MARK30.81371422
55JAK20.79452446
56MAP3K110.79377610
57IKBKB0.78873066
58KSR20.77691231
59MAP3K10.76874536
60TAOK20.76137344
61UHMK10.75258273
62PRKCH0.74822495
63TYRO30.73000679
64TAOK30.70691487
65CDK190.67484841
66STK100.63576868
67MAPK70.63016313
68PRKD20.61212662
69PIM10.60924532
70KIT0.60865566
71TESK20.58417665
72EPHB10.58345034
73MELK0.54289086
74IRAK20.50730844
75PDPK10.49035990
76PRKD30.48344460
77CAMKK20.47862371
78BMPR20.45522450
79LRRK20.44344921
80CDK60.43377815
81ALK0.43043111
82FGR0.42999627
83RPS6KC10.41133589
84RPS6KL10.41133589
85FYN0.41058035
86MAP2K20.40549091
87PKN20.39460397
88STK110.39067572
89MAPK40.38690699
90MAP3K80.38644639
91RET0.37519609
92SGK30.36889231
93CDK90.35999807
94CAMK40.33655459
95CHUK0.32472497
96PTK60.32016291
97MAP3K30.31902985
98FGFR20.30404289
99RPS6KA60.29099149
100MAP3K90.27869608

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.10036164
2B cell receptor signaling pathway_Homo sapiens_hsa046623.00421993
3Allograft rejection_Homo sapiens_hsa053302.85007428
4Autoimmune thyroid disease_Homo sapiens_hsa053202.70192298
5Graft-versus-host disease_Homo sapiens_hsa053322.54339486
6T cell receptor signaling pathway_Homo sapiens_hsa046602.54247901
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.31231437
8Type I diabetes mellitus_Homo sapiens_hsa049402.09094503
9Acute myeloid leukemia_Homo sapiens_hsa052212.08971834
10Leishmaniasis_Homo sapiens_hsa051402.07042180
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04919432
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.98341669
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95506147
14Osteoclast differentiation_Homo sapiens_hsa043801.93388385
15Measles_Homo sapiens_hsa051621.88799097
16Asthma_Homo sapiens_hsa053101.76147162
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76059695
18Viral myocarditis_Homo sapiens_hsa054161.73224609
19Antigen processing and presentation_Homo sapiens_hsa046121.68655663
20Herpes simplex infection_Homo sapiens_hsa051681.67056689
21Non-small cell lung cancer_Homo sapiens_hsa052231.66595222
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61563018
23Hematopoietic cell lineage_Homo sapiens_hsa046401.55635211
24Influenza A_Homo sapiens_hsa051641.45935325
25Chronic myeloid leukemia_Homo sapiens_hsa052201.44725606
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44366014
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41485092
28Hepatitis B_Homo sapiens_hsa051611.41251363
29Toxoplasmosis_Homo sapiens_hsa051451.31621741
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.26068045
31Tuberculosis_Homo sapiens_hsa051521.24339230
32Epstein-Barr virus infection_Homo sapiens_hsa051691.23337716
33Chemokine signaling pathway_Homo sapiens_hsa040621.22884001
34Pancreatic cancer_Homo sapiens_hsa052121.21264364
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19005475
36VEGF signaling pathway_Homo sapiens_hsa043701.17701426
37Staphylococcus aureus infection_Homo sapiens_hsa051501.16238976
38HTLV-I infection_Homo sapiens_hsa051661.14511978
39Viral carcinogenesis_Homo sapiens_hsa052031.09078897
40Colorectal cancer_Homo sapiens_hsa052101.07761685
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.05918047
42TNF signaling pathway_Homo sapiens_hsa046680.99758833
43Apoptosis_Homo sapiens_hsa042100.96378303
44Endometrial cancer_Homo sapiens_hsa052130.95614823
45Hepatitis C_Homo sapiens_hsa051600.93184161
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93027869
47Long-term potentiation_Homo sapiens_hsa047200.91536443
48Prolactin signaling pathway_Homo sapiens_hsa049170.90555079
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87421737
50mTOR signaling pathway_Homo sapiens_hsa041500.86917615
51Inositol phosphate metabolism_Homo sapiens_hsa005620.86903854
52Renal cell carcinoma_Homo sapiens_hsa052110.83852147
53Notch signaling pathway_Homo sapiens_hsa043300.83640654
54Choline metabolism in cancer_Homo sapiens_hsa052310.81835294
55Platelet activation_Homo sapiens_hsa046110.80416568
56Other glycan degradation_Homo sapiens_hsa005110.80227531
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.79094313
58Glioma_Homo sapiens_hsa052140.78888107
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.78129088
60Prostate cancer_Homo sapiens_hsa052150.76013640
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74933915
62GnRH signaling pathway_Homo sapiens_hsa049120.72758541
63ErbB signaling pathway_Homo sapiens_hsa040120.72276916
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69389297
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68576736
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68531415
67MAPK signaling pathway_Homo sapiens_hsa040100.67765129
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.65563217
69FoxO signaling pathway_Homo sapiens_hsa040680.63918323
70Thyroid cancer_Homo sapiens_hsa052160.63364824
71African trypanosomiasis_Homo sapiens_hsa051430.61382891
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60666399
73Shigellosis_Homo sapiens_hsa051310.59688490
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57817551
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56451123
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54199791
77mRNA surveillance pathway_Homo sapiens_hsa030150.54020873
78Malaria_Homo sapiens_hsa051440.51958489
79HIF-1 signaling pathway_Homo sapiens_hsa040660.51162589
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48078457
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47640150
82Type II diabetes mellitus_Homo sapiens_hsa049300.47615759
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47285882
84Endocytosis_Homo sapiens_hsa041440.46153619
85Systemic lupus erythematosus_Homo sapiens_hsa053220.45557088
86DNA replication_Homo sapiens_hsa030300.45496470
87Spliceosome_Homo sapiens_hsa030400.44694777
88Estrogen signaling pathway_Homo sapiens_hsa049150.44414433
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42685906
90Insulin resistance_Homo sapiens_hsa049310.42351113
91Insulin signaling pathway_Homo sapiens_hsa049100.42105265
92Rheumatoid arthritis_Homo sapiens_hsa053230.40124271
93Legionellosis_Homo sapiens_hsa051340.38508026
94Cholinergic synapse_Homo sapiens_hsa047250.37174825
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.36844604
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.36022127
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34723675
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34289074
99Ras signaling pathway_Homo sapiens_hsa040140.34200384
100Base excision repair_Homo sapiens_hsa034100.33885148

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