CARMIL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.58714218
2postsynaptic membrane organization (GO:0001941)5.65345851
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61740141
4dendritic spine morphogenesis (GO:0060997)5.39111898
5pyrimidine nucleobase catabolic process (GO:0006208)5.34783962
6protein localization to synapse (GO:0035418)5.26311972
7sodium ion export (GO:0071436)5.23347388
8regulation of synaptic vesicle exocytosis (GO:2000300)5.13773822
9neuron cell-cell adhesion (GO:0007158)5.07381296
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02769995
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02365414
12vocalization behavior (GO:0071625)5.02303006
13locomotory exploration behavior (GO:0035641)4.98390269
14synaptic vesicle exocytosis (GO:0016079)4.92632801
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89962658
16establishment of mitochondrion localization (GO:0051654)4.89096344
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.77612005
18cellular potassium ion homeostasis (GO:0030007)4.73442211
19glutamate secretion (GO:0014047)4.65156711
20presynaptic membrane assembly (GO:0097105)4.63886623
21neurotransmitter-gated ion channel clustering (GO:0072578)4.62822603
22neurotransmitter secretion (GO:0007269)4.62609477
23cell migration in hindbrain (GO:0021535)4.52958138
24presynaptic membrane organization (GO:0097090)4.52749508
25neuron recognition (GO:0008038)4.50133385
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.42816088
27synaptic transmission, glutamatergic (GO:0035249)4.41229286
28axonal fasciculation (GO:0007413)4.39644177
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.39001218
30mitochondrion transport along microtubule (GO:0047497)4.39001218
31regulation of synaptic vesicle transport (GO:1902803)4.31131324
32cerebellar Purkinje cell differentiation (GO:0021702)4.27220771
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.20972717
34nucleobase catabolic process (GO:0046113)4.20936735
35exploration behavior (GO:0035640)4.18325624
36neuronal ion channel clustering (GO:0045161)4.15618809
37positive regulation of synapse maturation (GO:0090129)4.14709189
38regulation of glutamate receptor signaling pathway (GO:1900449)4.10904058
39auditory behavior (GO:0031223)4.09433185
40layer formation in cerebral cortex (GO:0021819)4.06477879
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.00734685
42gamma-aminobutyric acid transport (GO:0015812)3.91748911
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87095025
44transmission of nerve impulse (GO:0019226)3.81851251
45positive regulation of synapse assembly (GO:0051965)3.75149806
46regulation of vesicle fusion (GO:0031338)3.68994944
47neuron-neuron synaptic transmission (GO:0007270)3.67251362
48regulation of synapse structural plasticity (GO:0051823)3.65947979
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63509758
50glutamate receptor signaling pathway (GO:0007215)3.59520187
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59310231
52neurotransmitter transport (GO:0006836)3.57717562
53positive regulation of dendritic spine development (GO:0060999)3.56819294
54synapse assembly (GO:0007416)3.56312658
55dendritic spine organization (GO:0097061)3.55734600
56neuronal action potential propagation (GO:0019227)3.54854503
57positive regulation of dendritic spine morphogenesis (GO:0061003)3.52355576
58regulation of neuronal synaptic plasticity (GO:0048168)3.51876560
59ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.51753487
60cerebellar granule cell differentiation (GO:0021707)3.50362655
61dendrite morphogenesis (GO:0048813)3.48772000
62membrane depolarization during action potential (GO:0086010)3.48642843
63central nervous system projection neuron axonogenesis (GO:0021952)3.48167609
64regulation of neurotransmitter levels (GO:0001505)3.47466241
65mechanosensory behavior (GO:0007638)3.47269780
66adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.46173269
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45789930
68cell communication by electrical coupling (GO:0010644)3.44051166
69potassium ion homeostasis (GO:0055075)3.42155184
70regulation of neurotransmitter secretion (GO:0046928)3.38162549
71synaptic vesicle endocytosis (GO:0048488)3.37040650
72prepulse inhibition (GO:0060134)3.36784350
73neuromuscular synaptic transmission (GO:0007274)3.34384649
74adult walking behavior (GO:0007628)3.33382450
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32036861
76membrane hyperpolarization (GO:0060081)3.29555178
77response to auditory stimulus (GO:0010996)3.27117330
78positive regulation of membrane potential (GO:0045838)3.26684756
79regulation of synapse maturation (GO:0090128)3.22535587
80cellular sodium ion homeostasis (GO:0006883)3.20551322
81regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19169550
82cell differentiation in hindbrain (GO:0021533)3.17988644
83regulation of synapse assembly (GO:0051963)3.16129640
84regulation of postsynaptic membrane potential (GO:0060078)3.15615101
85neuromuscular process controlling balance (GO:0050885)3.15580473
86regulation of respiratory system process (GO:0044065)3.14926437
87axon extension (GO:0048675)3.13045672
88neuromuscular process controlling posture (GO:0050884)3.12021818
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.08743792
90membrane depolarization (GO:0051899)3.07504441
91negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04550424
92regulation of neurotransmitter transport (GO:0051588)3.03808326
93establishment of nucleus localization (GO:0040023)2.99754609
94regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95603589
95synapse organization (GO:0050808)2.93920350
96neurofilament cytoskeleton organization (GO:0060052)2.90704903
97response to dietary excess (GO:0002021)2.90359601
98long-term memory (GO:0007616)2.89833558
99regulation of synapse organization (GO:0050807)2.87679032
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87651912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.65475583
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.66532548
3REST_21632747_ChIP-Seq_MESCs_Mouse3.35212759
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.17527394
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00044535
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.85929071
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.73277787
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72801595
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.69704888
10DROSHA_22980978_ChIP-Seq_HELA_Human2.59381486
11SUZ12_27294783_Chip-Seq_ESCs_Mouse2.58512583
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54334255
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.52993323
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46281766
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.45059089
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37918583
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36960305
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36960305
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34536095
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.31278353
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.30541004
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28100999
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21688818
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18265331
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.13841216
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07444616
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98466867
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.98362062
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97859505
30GBX2_23144817_ChIP-Seq_PC3_Human1.93602505
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.89904466
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81652459
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81341546
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.80575224
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76734471
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76638633
37KDM2B_26808549_Chip-Seq_K562_Human1.66335376
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.64425485
39IGF1R_20145208_ChIP-Seq_DFB_Human1.57473096
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57007920
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.54338884
42RNF2_27304074_Chip-Seq_NSC_Mouse1.49032275
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41168705
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39416346
45CTCF_27219007_Chip-Seq_Bcells_Human1.36883345
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36257511
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35834545
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33899673
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33185533
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30761920
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.27404862
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.23118075
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20293864
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18621601
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17799454
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17799454
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15790946
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15494508
59AR_21572438_ChIP-Seq_LNCaP_Human1.11140726
60AR_19668381_ChIP-Seq_PC3_Human1.10866741
61OCT4_19829295_ChIP-Seq_ESCs_Human1.07494576
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06677684
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05400008
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.03730695
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02523379
66KDM2B_26808549_Chip-Seq_DND41_Human1.02431529
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02126713
68TET1_21490601_ChIP-Seq_MESCs_Mouse0.97199515
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96733653
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95442006
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93094025
72SMAD4_21799915_ChIP-Seq_A2780_Human0.93040935
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93026715
74ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92632606
75RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91749347
76LXR_22292898_ChIP-Seq_THP-1_Human0.88254358
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87484734
78SMC4_20622854_ChIP-Seq_HELA_Human0.86708101
79CREB1_26743006_Chip-Seq_LNCaP_Human0.85393258
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84992716
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84731183
82NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84320350
83SOX2_21211035_ChIP-Seq_LN229_Gbm0.83193425
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82816348
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82674304
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81297214
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.81217266
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80948732
89DPY_21335234_ChIP-Seq_ESCs_Mouse0.80832504
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79556973
91TAF15_26573619_Chip-Seq_HEK293_Human0.78563183
92SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76127375
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.75706385
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.75415858
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75367690
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74705681
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73995561
98RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73118468
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72340096
100SMAD4_21741376_ChIP-Seq_ESCs_Human0.72144729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous5.32931147
2MP0004859_abnormal_synaptic_plasticity5.21158962
3MP0003880_abnormal_central_pattern3.73624325
4MP0004270_analgesia3.52475274
5MP0003635_abnormal_synaptic_transmissio3.42827113
6MP0003122_maternal_imprinting2.99283584
7MP0003787_abnormal_imprinting2.97624658
8MP0000778_abnormal_nervous_system2.85999000
9MP0002822_catalepsy2.83321712
10MP0002063_abnormal_learning/memory/cond2.82654381
11MP0002734_abnormal_mechanical_nocicepti2.74790087
12MP0009745_abnormal_behavioral_response2.73754958
13MP0002735_abnormal_chemical_nociception2.61823415
14MP0002064_seizures2.59007970
15MP0009046_muscle_twitch2.56330901
16MP0002572_abnormal_emotion/affect_behav2.45765967
17MP0006276_abnormal_autonomic_nervous2.41646377
18MP0002272_abnormal_nervous_system2.40943755
19MP0001970_abnormal_pain_threshold2.20205755
20MP0001486_abnormal_startle_reflex2.18917330
21MP0002733_abnormal_thermal_nociception2.12009110
22MP0001968_abnormal_touch/_nociception2.10326390
23MP0003121_genomic_imprinting2.07219183
24MP0000955_abnormal_spinal_cord2.01801548
25MP0003329_amyloid_beta_deposits1.97738871
26MP0001986_abnormal_taste_sensitivity1.94601889
27MP0002184_abnormal_innervation1.93997847
28MP0002557_abnormal_social/conspecific_i1.91016139
29MP0004811_abnormal_neuron_physiology1.89328501
30MP0001188_hyperpigmentation1.80832074
31MP0003123_paternal_imprinting1.80493835
32MP0002882_abnormal_neuron_morphology1.76166534
33MP0002067_abnormal_sensory_capabilities1.71832992
34MP0004742_abnormal_vestibular_system1.71804306
35MP0001440_abnormal_grooming_behavior1.69756472
36MP0008569_lethality_at_weaning1.69438230
37MP0001984_abnormal_olfaction1.66368820
38MP0005645_abnormal_hypothalamus_physiol1.63635647
39MP0004142_abnormal_muscle_tone1.58366858
40MP0008877_abnormal_DNA_methylation1.54157858
41MP0002909_abnormal_adrenal_gland1.49922628
42MP0003690_abnormal_glial_cell1.44322159
43MP0002736_abnormal_nociception_after1.42243896
44MP0002653_abnormal_ependyma_morphology1.39917223
45MP0005386_behavior/neurological_phenoty1.38647409
46MP0004924_abnormal_behavior1.38647409
47MP0010386_abnormal_urinary_bladder1.36965620
48MP0002066_abnormal_motor_capabilities/c1.36852326
49MP0002152_abnormal_brain_morphology1.36779687
50MP0001501_abnormal_sleep_pattern1.36637753
51MP0003879_abnormal_hair_cell1.35066435
52MP0002638_abnormal_pupillary_reflex1.31590125
53MP0001502_abnormal_circadian_rhythm1.31053810
54MP0005499_abnormal_olfactory_system1.29371937
55MP0005394_taste/olfaction_phenotype1.29371937
56MP0006292_abnormal_olfactory_placode1.27740978
57MP0005167_abnormal_blood-brain_barrier1.20526457
58MP0001529_abnormal_vocalization1.19321974
59MP0002752_abnormal_somatic_nervous1.18035162
60MP0002229_neurodegeneration1.14315017
61MP0001905_abnormal_dopamine_level1.13924043
62MP0000537_abnormal_urethra_morphology1.06939937
63MP0003861_abnormal_nervous_system1.02030015
64MP0003633_abnormal_nervous_system1.01991899
65MP0005551_abnormal_eye_electrophysiolog0.97015142
66MP0000604_amyloidosis0.96893642
67MP0003631_nervous_system_phenotype0.92336939
68MP0000631_abnormal_neuroendocrine_gland0.91193688
69MP0002069_abnormal_eating/drinking_beha0.90483790
70MP0001963_abnormal_hearing_physiology0.88966159
71MP0004885_abnormal_endolymph0.88389760
72MP0005646_abnormal_pituitary_gland0.87430489
73MP0003634_abnormal_glial_cell0.84789718
74MP0002102_abnormal_ear_morphology0.82715706
75MP0001485_abnormal_pinna_reflex0.81435420
76MP0000920_abnormal_myelination0.77447087
77MP0003632_abnormal_nervous_system0.74036031
78MP0001348_abnormal_lacrimal_gland0.72331236
79MP0000026_abnormal_inner_ear0.72140597
80MP0001943_abnormal_respiration0.69040005
81MP0001177_atelectasis0.67140554
82MP0010770_preweaning_lethality0.65949110
83MP0002082_postnatal_lethality0.65949110
84MP0002751_abnormal_autonomic_nervous0.65914578
85MP0000579_abnormal_nail_morphology0.65275875
86MP0010769_abnormal_survival0.64804150
87MP0003938_abnormal_ear_development0.64005781
88MP0004130_abnormal_muscle_cell0.62629295
89MP0005253_abnormal_eye_physiology0.62556793
90MP0008874_decreased_physiological_sensi0.61792031
91MP0010768_mortality/aging0.61710937
92MP0002081_perinatal_lethality0.59436133
93MP0005195_abnormal_posterior_eye0.53789953
94MP0005409_darkened_coat_color0.53076726
95MP0003119_abnormal_digestive_system0.52263013
96MP0008995_early_reproductive_senescence0.52212131
97MP0004133_heterotaxia0.52025772
98MP0003698_abnormal_male_reproductive0.49450343
99MP0000569_abnormal_digit_pigmentation0.49170777
100MP0000534_abnormal_ureter_morphology0.48059606

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.03159201
2Focal seizures (HP:0007359)4.43487828
3Limb dystonia (HP:0002451)4.39855587
4Focal motor seizures (HP:0011153)4.37459586
5Urinary bladder sphincter dysfunction (HP:0002839)4.32901868
6Supranuclear gaze palsy (HP:0000605)4.17599541
7Genetic anticipation (HP:0003743)4.12975443
8Agitation (HP:0000713)3.94688312
9Polyphagia (HP:0002591)3.82150320
10Progressive cerebellar ataxia (HP:0002073)3.81126510
11Epileptic encephalopathy (HP:0200134)3.74763236
12Abnormality of the corticospinal tract (HP:0002492)3.73440052
13Ankle clonus (HP:0011448)3.72568820
14Febrile seizures (HP:0002373)3.72075040
15Spastic gait (HP:0002064)3.67989016
16Abnormality of binocular vision (HP:0011514)3.38020871
17Diplopia (HP:0000651)3.38020871
18Abnormality of the lower motor neuron (HP:0002366)3.35199849
19Action tremor (HP:0002345)3.32607382
20Urinary urgency (HP:0000012)3.30478285
21Drooling (HP:0002307)3.29319351
22Impaired vibration sensation in the lower limbs (HP:0002166)3.22745522
23Abnormal eating behavior (HP:0100738)3.19215917
24Excessive salivation (HP:0003781)3.14703177
25Mutism (HP:0002300)3.13958698
26Neurofibrillary tangles (HP:0002185)3.13922572
27Amblyopia (HP:0000646)3.13515031
28Atonic seizures (HP:0010819)3.12445636
29Torticollis (HP:0000473)3.07226159
30Cerebral inclusion bodies (HP:0100314)2.98651702
31Generalized tonic-clonic seizures (HP:0002069)2.86093402
32Akinesia (HP:0002304)2.85307329
33Focal dystonia (HP:0004373)2.79975450
34Broad-based gait (HP:0002136)2.78818541
35Morphological abnormality of the pyramidal tract (HP:0002062)2.77779614
36Epileptiform EEG discharges (HP:0011182)2.70224215
37Protruding tongue (HP:0010808)2.67193701
38Craniofacial dystonia (HP:0012179)2.64459215
39Apathy (HP:0000741)2.64221629
40Fetal akinesia sequence (HP:0001989)2.63800755
41EEG with generalized epileptiform discharges (HP:0011198)2.62562661
42Hepatoblastoma (HP:0002884)2.62460575
43Hypsarrhythmia (HP:0002521)2.61743548
44Sleep apnea (HP:0010535)2.60845809
45Intention tremor (HP:0002080)2.57979098
46Retinal dysplasia (HP:0007973)2.55822537
47Dialeptic seizures (HP:0011146)2.52258812
48Diminished motivation (HP:0000745)2.50303682
49Hyperventilation (HP:0002883)2.50123614
50Esotropia (HP:0000565)2.50119782
51Absence seizures (HP:0002121)2.46201247
52Postural instability (HP:0002172)2.46164564
53Hemiplegia (HP:0002301)2.45991311
54Failure to thrive in infancy (HP:0001531)2.45648779
55Visual hallucinations (HP:0002367)2.45245408
56Inappropriate behavior (HP:0000719)2.45127494
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.44282295
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44282295
59Depression (HP:0000716)2.43411153
60Lower limb muscle weakness (HP:0007340)2.43291567
61Restlessness (HP:0000711)2.41664941
62Hypoplasia of the brainstem (HP:0002365)2.38848575
63Aplasia/Hypoplasia of the brainstem (HP:0007362)2.38848575
64Lissencephaly (HP:0001339)2.35813108
65Status epilepticus (HP:0002133)2.35589406
66Spastic tetraparesis (HP:0001285)2.31914132
67Paraplegia (HP:0010550)2.29372115
68Impaired social interactions (HP:0000735)2.26435589
69Abnormal social behavior (HP:0012433)2.26435589
70Spastic tetraplegia (HP:0002510)2.24991662
71Impaired smooth pursuit (HP:0007772)2.24321964
72Spastic paraplegia (HP:0001258)2.24082775
73Amyotrophic lateral sclerosis (HP:0007354)2.21677548
74Hemiparesis (HP:0001269)2.18938597
75Absent speech (HP:0001344)2.17750120
76Intellectual disability, severe (HP:0010864)2.17537006
77Neuronal loss in central nervous system (HP:0002529)2.15166257
78Dysmetria (HP:0001310)2.12175360
79Hypoplasia of the corpus callosum (HP:0002079)2.11713748
80Truncal ataxia (HP:0002078)2.11132851
81Cortical dysplasia (HP:0002539)2.10154876
82Peripheral hypomyelination (HP:0007182)2.09564609
83Poor eye contact (HP:0000817)2.07835609
84Termporal pattern (HP:0011008)2.05423274
85Insidious onset (HP:0003587)2.05423274
86Obstructive sleep apnea (HP:0002870)2.04945911
87Insomnia (HP:0100785)2.04571430
88Stereotypic behavior (HP:0000733)2.04116141
89Papilledema (HP:0001085)2.02907356
90Impaired vibratory sensation (HP:0002495)1.97566342
91Bradykinesia (HP:0002067)1.96086888
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92928997
93Gait imbalance (HP:0002141)1.92037140
94Anxiety (HP:0000739)1.84276201
95Pointed chin (HP:0000307)1.84065561
96Disinhibition (HP:0000734)1.83117968
97Abnormality of salivation (HP:0100755)1.81985823
98Obsessive-compulsive behavior (HP:0000722)1.80654674
99Abnormality of ocular smooth pursuit (HP:0000617)1.80315815
100Sporadic (HP:0003745)1.79768138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.80395216
2CASK3.50950598
3NTRK32.94236030
4NTRK22.93572394
5SIK22.71686394
6MAP3K92.48146872
7MINK12.24978868
8MAP3K42.19755845
9MAP2K72.16867627
10MAPK132.14507347
11EPHA42.12719863
12CAMKK12.08021963
13TYRO32.01488369
14DAPK21.77385810
15KSR11.69146639
16PAK61.57214811
17DYRK21.55029033
18CAMK1G1.54643902
19MAP2K41.48918678
20CAMK1D1.47466687
21ICK1.45234706
22CDK51.39443719
23PRKD31.36955043
24MAP4K11.32219234
25SGK4941.30822947
26SGK2231.30822947
27MARK21.28085502
28UHMK11.26587145
29PRKCH1.20990458
30NTRK11.20711423
31PRKCG1.18174735
32PHKG21.17741441
33PHKG11.17741441
34MAP3K111.13402203
35DYRK1A1.09379165
36PNCK1.06309136
37TNK21.03987676
38BCR1.02019418
39CSNK1G21.00865971
40SGK20.99804515
41PINK10.94950586
42BLK0.94880535
43STK110.94283194
44EPHB20.93410748
45RPS6KA20.90790204
46PKN10.85881750
47MAP3K100.85773284
48CDK190.85667334
49SGK30.84947639
50ITK0.79291452
51CDK140.78699626
52DYRK1B0.78324732
53PAK30.77002304
54CDK150.76923463
55CDK180.76001355
56CAMK10.75669122
57CAMKK20.75482782
58CDK11A0.75455523
59TRIB30.75265390
60MAP3K60.74259515
61STK160.73347345
62PRKCZ0.72616623
63FYN0.69335122
64RIPK10.67249862
65FES0.65623824
66CSNK1G30.65371441
67CAMK2A0.61458303
68MAPK100.59680749
69RET0.58856657
70PRKAA10.58821655
71CAMK2B0.58617393
72MAPK120.57243540
73TAOK10.55263793
74CAMK40.53992490
75LATS20.53894255
76SIK30.52850572
77ALK0.52615599
78BRD40.51752401
79FGFR20.50785955
80EPHA30.50026350
81LMTK20.49558806
82ERBB20.47965784
83SGK10.47238597
84CSNK1A1L0.44634333
85RPS6KA30.42416693
86PLK20.41499631
87MAPK80.40304870
88CSNK1D0.39561460
89CSNK1G10.38330632
90CSNK1E0.38327521
91FGFR40.37910761
92RPS6KB10.37074473
93INSRR0.35118029
94WNK30.34883463
95CSNK1A10.34106678
96PRPF4B0.32784092
97GSK3B0.32451914
98MAP2K60.31552859
99PDK10.31486617
100JAK30.30957876

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.78787039
2Synaptic vesicle cycle_Homo sapiens_hsa047213.66143244
3GABAergic synapse_Homo sapiens_hsa047272.89656957
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78894225
5Glutamatergic synapse_Homo sapiens_hsa047242.73038371
6Morphine addiction_Homo sapiens_hsa050322.70634685
7Circadian entrainment_Homo sapiens_hsa047132.48106438
8Cocaine addiction_Homo sapiens_hsa050302.46758249
9Insulin secretion_Homo sapiens_hsa049112.40180875
10Dopaminergic synapse_Homo sapiens_hsa047282.33778437
11Amphetamine addiction_Homo sapiens_hsa050312.12943989
12Taste transduction_Homo sapiens_hsa047422.09994621
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03613834
14Cholinergic synapse_Homo sapiens_hsa047252.00038057
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.93013523
16Axon guidance_Homo sapiens_hsa043601.77811835
17Long-term potentiation_Homo sapiens_hsa047201.70330390
18Long-term depression_Homo sapiens_hsa047301.65276978
19Gastric acid secretion_Homo sapiens_hsa049711.61134342
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49864948
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49403193
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45539866
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41343583
24Type II diabetes mellitus_Homo sapiens_hsa049301.40472458
25Salivary secretion_Homo sapiens_hsa049701.37061513
26cAMP signaling pathway_Homo sapiens_hsa040241.36136786
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32886999
28Serotonergic synapse_Homo sapiens_hsa047261.30146635
29Gap junction_Homo sapiens_hsa045401.25349916
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24076667
31Oxytocin signaling pathway_Homo sapiens_hsa049211.17982919
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07776157
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07226236
34Estrogen signaling pathway_Homo sapiens_hsa049151.06947152
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.05251864
36GnRH signaling pathway_Homo sapiens_hsa049121.00350951
37ErbB signaling pathway_Homo sapiens_hsa040120.99397070
38Calcium signaling pathway_Homo sapiens_hsa040200.95709700
39Phototransduction_Homo sapiens_hsa047440.95458449
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95363079
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94016100
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93871729
43Collecting duct acid secretion_Homo sapiens_hsa049660.92939172
44Alcoholism_Homo sapiens_hsa050340.91434256
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.90489159
46Cardiac muscle contraction_Homo sapiens_hsa042600.89254008
47MAPK signaling pathway_Homo sapiens_hsa040100.86695074
48Notch signaling pathway_Homo sapiens_hsa043300.85178906
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84704106
50Olfactory transduction_Homo sapiens_hsa047400.81630942
51Vibrio cholerae infection_Homo sapiens_hsa051100.80392841
52Choline metabolism in cancer_Homo sapiens_hsa052310.79174798
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78772621
54Bile secretion_Homo sapiens_hsa049760.78297624
55Ras signaling pathway_Homo sapiens_hsa040140.76712754
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76537820
57Pancreatic secretion_Homo sapiens_hsa049720.73536673
58Renin secretion_Homo sapiens_hsa049240.73001802
59Melanogenesis_Homo sapiens_hsa049160.70807715
60VEGF signaling pathway_Homo sapiens_hsa043700.70223046
61Glioma_Homo sapiens_hsa052140.67954306
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67809044
63Prolactin signaling pathway_Homo sapiens_hsa049170.66902738
64Rap1 signaling pathway_Homo sapiens_hsa040150.66232457
65Thyroid hormone synthesis_Homo sapiens_hsa049180.66155894
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65200004
67Dorso-ventral axis formation_Homo sapiens_hsa043200.64926539
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63807878
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61269487
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61200724
71Inositol phosphate metabolism_Homo sapiens_hsa005620.59582234
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58724725
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.58245571
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58115830
75Ovarian steroidogenesis_Homo sapiens_hsa049130.57207171
76Oocyte meiosis_Homo sapiens_hsa041140.55438360
77B cell receptor signaling pathway_Homo sapiens_hsa046620.53874756
78Endocytosis_Homo sapiens_hsa041440.53012207
79AMPK signaling pathway_Homo sapiens_hsa041520.50987249
80Endometrial cancer_Homo sapiens_hsa052130.49865175
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.48167667
82Colorectal cancer_Homo sapiens_hsa052100.46017232
83Insulin signaling pathway_Homo sapiens_hsa049100.44511904
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44180252
85ABC transporters_Homo sapiens_hsa020100.42496796
86Ether lipid metabolism_Homo sapiens_hsa005650.38210186
87Chemokine signaling pathway_Homo sapiens_hsa040620.37712451
88Butanoate metabolism_Homo sapiens_hsa006500.36744626
89mTOR signaling pathway_Homo sapiens_hsa041500.36573740
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35597996
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35075737
92mRNA surveillance pathway_Homo sapiens_hsa030150.34777371
93Vitamin B6 metabolism_Homo sapiens_hsa007500.34382075
94Salmonella infection_Homo sapiens_hsa051320.31226807
95Dilated cardiomyopathy_Homo sapiens_hsa054140.30686283
96Glucagon signaling pathway_Homo sapiens_hsa049220.29943130
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29793373
98Hippo signaling pathway_Homo sapiens_hsa043900.29785231
99Wnt signaling pathway_Homo sapiens_hsa043100.29309377
100Prion diseases_Homo sapiens_hsa050200.28856793

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