CARNMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.93750251
2ribosomal small subunit assembly (GO:0000028)4.81734286
3viral transcription (GO:0019083)4.53423577
4translational termination (GO:0006415)4.50350118
5DNA strand elongation involved in DNA replication (GO:0006271)4.41707169
6DNA deamination (GO:0045006)4.38203752
7DNA replication initiation (GO:0006270)4.35452557
8maturation of SSU-rRNA (GO:0030490)4.31109293
9regulation of DNA endoreduplication (GO:0032875)4.29138661
10telomere maintenance via semi-conservative replication (GO:0032201)4.28116895
11DNA unwinding involved in DNA replication (GO:0006268)4.22971663
12IMP biosynthetic process (GO:0006188)4.21247791
13DNA strand elongation (GO:0022616)4.17427932
14formation of translation preinitiation complex (GO:0001731)4.17306588
15folic acid-containing compound biosynthetic process (GO:0009396)4.16967836
16IMP metabolic process (GO:0046040)4.11561385
17translational elongation (GO:0006414)4.07774879
18negative regulation of DNA-dependent DNA replication (GO:2000104)4.04081135
19regulation of centriole replication (GO:0046599)3.92364053
20translational initiation (GO:0006413)3.92145549
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79992270
22telomere maintenance via recombination (GO:0000722)3.79211808
23ribosomal large subunit biogenesis (GO:0042273)3.77731209
24ribosomal small subunit biogenesis (GO:0042274)3.75013190
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74230374
26protein targeting to ER (GO:0045047)3.68662959
27establishment of chromosome localization (GO:0051303)3.68657229
28cotranslational protein targeting to membrane (GO:0006613)3.66971769
29sister chromatid segregation (GO:0000819)3.66161069
30nuclear pore organization (GO:0006999)3.61786085
31mitotic recombination (GO:0006312)3.61241940
32mitotic nuclear envelope disassembly (GO:0007077)3.57787911
33double-strand break repair via nonhomologous end joining (GO:0006303)3.57770465
34non-recombinational repair (GO:0000726)3.57770465
35protein localization to kinetochore (GO:0034501)3.56825461
36nucleobase biosynthetic process (GO:0046112)3.56704709
37DNA replication-dependent nucleosome assembly (GO:0006335)3.52145637
38DNA replication-dependent nucleosome organization (GO:0034723)3.52145637
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51660108
40ribonucleoprotein complex biogenesis (GO:0022613)3.50020340
41DNA replication checkpoint (GO:0000076)3.48611534
42protein localization to endoplasmic reticulum (GO:0070972)3.46222732
43chromatin remodeling at centromere (GO:0031055)3.45755497
44viral life cycle (GO:0019058)3.43753352
45nuclear pore complex assembly (GO:0051292)3.43067874
46purine nucleobase biosynthetic process (GO:0009113)3.41866047
47cellular protein complex disassembly (GO:0043624)3.39638238
48ribosome biogenesis (GO:0042254)3.39340807
49CENP-A containing nucleosome assembly (GO:0034080)3.38916661
50mitotic metaphase plate congression (GO:0007080)3.36498228
51protein complex localization (GO:0031503)3.34158299
52spindle checkpoint (GO:0031577)3.33515571
53response to X-ray (GO:0010165)3.33264518
54membrane disassembly (GO:0030397)3.32905905
55nuclear envelope disassembly (GO:0051081)3.32905905
56cellular protein complex localization (GO:0034629)3.32747878
57ribosome assembly (GO:0042255)3.32632476
58telomere maintenance via telomere lengthening (GO:0010833)3.29535818
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26790964
60negative regulation of DNA repair (GO:0045738)3.26754202
61mitotic spindle checkpoint (GO:0071174)3.25797489
62protein localization to chromosome, centromeric region (GO:0071459)3.24660659
63regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24546553
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24546553
65DNA replication-independent nucleosome assembly (GO:0006336)3.21320275
66DNA replication-independent nucleosome organization (GO:0034724)3.21320275
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21003706
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21003706
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21003706
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.21003706
71negative regulation of sister chromatid segregation (GO:0033046)3.21003706
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20534845
73regulation of chromosome segregation (GO:0051983)3.16904709
74negative regulation of chromosome segregation (GO:0051985)3.16749413
75sister chromatid cohesion (GO:0007062)3.16624253
76rRNA processing (GO:0006364)3.15520378
77positive regulation of chromosome segregation (GO:0051984)3.14916489
78regulation of centrosome cycle (GO:0046605)3.13344248
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.12351204
80regulation of sister chromatid segregation (GO:0033045)3.11731164
81regulation of mitotic sister chromatid separation (GO:0010965)3.11731164
82regulation of mitotic sister chromatid segregation (GO:0033047)3.11731164
83pseudouridine synthesis (GO:0001522)3.10732117
84mitotic G2/M transition checkpoint (GO:0044818)3.09238268
85telomere maintenance via telomerase (GO:0007004)3.08320413
86kinetochore organization (GO:0051383)3.08090017
87folic acid metabolic process (GO:0046655)3.07068856
88replication fork processing (GO:0031297)3.06040931
89somatic recombination of immunoglobulin gene segments (GO:0016447)3.04558584
90rRNA metabolic process (GO:0016072)3.04517801
91protein complex disassembly (GO:0043241)3.03886617
92mitotic chromosome condensation (GO:0007076)3.02855911
93translation (GO:0006412)3.02293605
94histone-serine phosphorylation (GO:0035404)3.01924682
95regulation of centrosome duplication (GO:0010824)3.00424507
96pteridine-containing compound biosynthetic process (GO:0042559)3.00174814
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.99395486
98mitotic spindle assembly checkpoint (GO:0007094)2.98855088
99nuclear-transcribed mRNA catabolic process (GO:0000956)2.97875355
100metaphase plate congression (GO:0051310)2.97701668
101synapsis (GO:0007129)2.96389245
102spindle assembly checkpoint (GO:0071173)2.94691297
103regulation of DNA-dependent DNA replication (GO:0090329)2.94427032
104transcription from mitochondrial promoter (GO:0006390)2.93654040
105DNA duplex unwinding (GO:0032508)2.93203485
106DNA geometric change (GO:0032392)2.90913371
107regulation of helicase activity (GO:0051095)2.90903729
108RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90419631
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.89961125
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89961125
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89961125
112protein K6-linked ubiquitination (GO:0085020)2.87328027
113macromolecular complex disassembly (GO:0032984)2.87135355
114RNA catabolic process (GO:0006401)2.85869799
115RNA-dependent DNA replication (GO:0006278)2.84776808
116mRNA catabolic process (GO:0006402)2.83817821
117mitochondrial DNA replication (GO:0006264)2.81300850
118somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80616381
119somatic cell DNA recombination (GO:0016444)2.80616381
120proteasome assembly (GO:0043248)2.80111580
121histone exchange (GO:0043486)2.79522307
122rRNA modification (GO:0000154)2.79471351
123DNA topological change (GO:0006265)2.78154414
124spliceosomal snRNP assembly (GO:0000387)2.75191470
125chromatin assembly or disassembly (GO:0006333)2.74947086
126kinetochore assembly (GO:0051382)2.70737992
127regulation of spindle organization (GO:0090224)2.69788820
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.69202308
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69202308
130oxidative phosphorylation (GO:0006119)2.66845148
131telomere maintenance (GO:0000723)2.65005719
132telomere organization (GO:0032200)2.64781803
133nuclear envelope organization (GO:0006998)2.63548660
134translesion synthesis (GO:0019985)2.61813129
135mitotic G1 DNA damage checkpoint (GO:0031571)2.61757662
136regulation of histone H3-K9 methylation (GO:0051570)2.61314645
137attachment of spindle microtubules to kinetochore (GO:0008608)2.60867071
138mitotic sister chromatid segregation (GO:0000070)2.59637749
139maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.59506715
140meiotic chromosome segregation (GO:0045132)2.59449604
141pore complex assembly (GO:0046931)2.59435152
142cellular component biogenesis (GO:0044085)2.58316370
143negative regulation of RNA splicing (GO:0033119)2.56065613
144establishment of integrated proviral latency (GO:0075713)2.53772544
145G1/S transition of mitotic cell cycle (GO:0000082)2.53659424
146cell cycle G1/S phase transition (GO:0044843)2.53659424
147somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53280258
148isotype switching (GO:0045190)2.53280258
149somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53280258
150pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.51812514
151negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50856689
152regulation of translational fidelity (GO:0006450)2.50130155
153DNA conformation change (GO:0071103)2.47223213
154termination of RNA polymerase II transcription (GO:0006369)2.47123262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.91911878
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.19924676
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95681310
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.60833829
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.41231356
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23795859
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79534344
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70436576
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64792199
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63722556
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54725319
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.39945274
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.36228767
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.33287920
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33055361
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27070545
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21268338
18AR_21909140_ChIP-Seq_LNCAP_Human2.07414815
19XRN2_22483619_ChIP-Seq_HELA_Human2.04726457
20FUS_26573619_Chip-Seq_HEK293_Human2.04591576
21VDR_23849224_ChIP-Seq_CD4+_Human2.03225630
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00828856
23EWS_26573619_Chip-Seq_HEK293_Human1.96012566
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91331652
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.86924886
26DCP1A_22483619_ChIP-Seq_HELA_Human1.86349015
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81396766
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80379864
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80111410
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79646628
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79227933
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79116036
33MYC_22102868_ChIP-Seq_BL_Human1.77748830
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77686521
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76245982
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71538126
37FOXP3_21729870_ChIP-Seq_TREG_Human1.69893156
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67406844
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.65827703
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63138154
41GABP_19822575_ChIP-Seq_HepG2_Human1.62458310
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61766995
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59984365
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57860132
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.56881092
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54807992
47TTF2_22483619_ChIP-Seq_HELA_Human1.52971406
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46833346
49ELK1_19687146_ChIP-ChIP_HELA_Human1.42780168
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42507958
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42016986
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41464839
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41113271
54KDM5A_27292631_Chip-Seq_BREAST_Human1.36789935
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35485025
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34415539
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33876144
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33709898
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33581928
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32985491
61CIITA_25753668_ChIP-Seq_RAJI_Human1.32666782
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30420849
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30361823
64ZNF263_19887448_ChIP-Seq_K562_Human1.30312423
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30129353
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28938761
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21459202
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20958175
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.20923967
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20776470
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20733325
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19809434
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19460461
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18864217
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18124977
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17735199
77TAF15_26573619_Chip-Seq_HEK293_Human1.17138601
78VDR_21846776_ChIP-Seq_THP-1_Human1.16309066
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15764457
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15324375
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14491101
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11940287
83TFEB_21752829_ChIP-Seq_HELA_Human1.11890065
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10419320
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10190607
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10184836
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10114934
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08195203
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.06854713
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06106753
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.05533390
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05439026
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05417470
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.04730039
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04043238
96P300_19829295_ChIP-Seq_ESCs_Human1.03894689
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03752441
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02830699
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.01460972
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99845544
101EZH2_27294783_Chip-Seq_NPCs_Mouse0.99683900
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98290784
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98163729
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97767449
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97432276
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97242230
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96455636
108CHD1_26751641_Chip-Seq_LNCaP_Human0.94490367
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94095127
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93278860
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93195647
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92783474
113SPI1_23547873_ChIP-Seq_NB4_Human0.92625629
114CDX2_22108803_ChIP-Seq_LS180_Human0.88929810
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88584824
116BRD4_25478319_ChIP-Seq_HGPS_Human0.87257801
117IGF1R_20145208_ChIP-Seq_DFB_Human0.86435315
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86272992
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86199222
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86003216
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85226829
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85187877
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84893532
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84404981
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83963605
126GATA1_22025678_ChIP-Seq_K562_Human0.83327102
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82945643
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82438767
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81580666
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80989933
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80497233
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80363888
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79794141
134MYC_18940864_ChIP-ChIP_HL60_Human0.79162087
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78743543
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78373641
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78036568
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76411932
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75949002
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75898079
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75750142
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75716003
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.75103766
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74998815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.08031292
2MP0004957_abnormal_blastocyst_morpholog3.68230782
3MP0010094_abnormal_chromosome_stability3.55494212
4MP0003941_abnormal_skin_development3.13963002
5MP0003111_abnormal_nucleus_morphology3.11833966
6MP0003806_abnormal_nucleotide_metabolis3.06666176
7MP0009697_abnormal_copulation3.00787557
8MP0003077_abnormal_cell_cycle2.90405462
9MP0008057_abnormal_DNA_replication2.88300455
10MP0010352_gastrointestinal_tract_polyps2.53845823
11MP0002396_abnormal_hematopoietic_system2.23500106
12MP0003646_muscle_fatigue2.17371366
13MP0008058_abnormal_DNA_repair2.15218567
14MP0008007_abnormal_cellular_replicative1.97351450
15MP0003890_abnormal_embryonic-extraembry1.93953035
16MP0000490_abnormal_crypts_of1.88246462
17MP0006036_abnormal_mitochondrial_physio1.86547476
18MP0010307_abnormal_tumor_latency1.84857363
19MP0001730_embryonic_growth_arrest1.82768854
20MP0002254_reproductive_system_inflammat1.82013632
21MP0008932_abnormal_embryonic_tissue1.76058864
22MP0003656_abnormal_erythrocyte_physiolo1.74734314
23MP0000350_abnormal_cell_proliferation1.74109538
24MP0003567_abnormal_fetal_cardiomyocyte1.72020395
25MP0001545_abnormal_hematopoietic_system1.71720133
26MP0005397_hematopoietic_system_phenotyp1.71720133
27MP0006054_spinal_hemorrhage1.69099803
28MP0000749_muscle_degeneration1.67320908
29MP0003705_abnormal_hypodermis_morpholog1.63697905
30MP0010678_abnormal_skin_adnexa1.63296947
31MP0001661_extended_life_span1.50985604
32MP0004145_abnormal_muscle_electrophysio1.49610455
33MP0002269_muscular_atrophy1.49318779
34MP0000750_abnormal_muscle_regeneration1.43257841
35MP0003937_abnormal_limbs/digits/tail_de1.42895423
36MP0004147_increased_porphyrin_level1.42721956
37MP0003221_abnormal_cardiomyocyte_apopto1.39972889
38MP0003186_abnormal_redox_activity1.39095618
39MP0002796_impaired_skin_barrier1.38067690
40MP0001697_abnormal_embryo_size1.37388344
41MP0001672_abnormal_embryogenesis/_devel1.36586704
42MP0005380_embryogenesis_phenotype1.36586704
43MP0003950_abnormal_plasma_membrane1.36484815
44MP0002019_abnormal_tumor_incidence1.35212250
45MP0000747_muscle_weakness1.32038600
46MP0003984_embryonic_growth_retardation1.31800364
47MP0002080_prenatal_lethality1.30109769
48MP0002088_abnormal_embryonic_growth/wei1.29719330
49MP0004808_abnormal_hematopoietic_stem1.27942386
50MP0004197_abnormal_fetal_growth/weight/1.27468338
51MP0002106_abnormal_muscle_physiology1.26712017
52MP0002086_abnormal_extraembryonic_tissu1.24334090
53MP0003786_premature_aging1.23604654
54MP0006035_abnormal_mitochondrial_morpho1.23203054
55MP0003123_paternal_imprinting1.21450089
56MP0004084_abnormal_cardiac_muscle1.21281838
57MP0000313_abnormal_cell_death1.19207773
58MP0002102_abnormal_ear_morphology1.19000367
59MP0001666_abnormal_nutrient_absorption1.16180685
60MP0003763_abnormal_thymus_physiology1.15524195
61MP0004087_abnormal_muscle_fiber1.14154419
62MP0003195_calcinosis1.12763134
63MP0009333_abnormal_splenocyte_physiolog1.10068028
64MP0005266_abnormal_metabolism1.09134225
65MP0005330_cardiomyopathy1.06887325
66MP0009703_decreased_birth_body1.04131712
67MP0000358_abnormal_cell_content/1.02733704
68MP0004264_abnormal_extraembryonic_tissu1.02078247
69MP0002084_abnormal_developmental_patter1.02026663
70MP0001853_heart_inflammation1.01474081
71MP0002085_abnormal_embryonic_tissue1.00987076
72MP0000759_abnormal_skeletal_muscle1.00814382
73MP0000427_abnormal_hair_cycle0.98965251
74MP0002398_abnormal_bone_marrow0.98898707
75MP0002722_abnormal_immune_system0.98621581
76MP0000689_abnormal_spleen_morphology0.98220793
77MP0005395_other_phenotype0.97420247
78MP0005076_abnormal_cell_differentiation0.96697423
79MP0000751_myopathy0.96578038
80MP0005408_hypopigmentation0.96505369
81MP0002166_altered_tumor_susceptibility0.95601937
82MP0000733_abnormal_muscle_development0.95598198
83MP0002233_abnormal_nose_morphology0.95558695
84MP0000537_abnormal_urethra_morphology0.94366921
85MP0003868_abnormal_feces_composition0.94050970
86MP0003943_abnormal_hepatobiliary_system0.92571855
87MP0000383_abnormal_hair_follicle0.90507197
88MP0000703_abnormal_thymus_morphology0.90303570
89MP0004036_abnormal_muscle_relaxation0.90140747
90MP0004185_abnormal_adipocyte_glucose0.89169113
91MP0001915_intracranial_hemorrhage0.88857762
92MP0002877_abnormal_melanocyte_morpholog0.88468616
93MP0009379_abnormal_foot_pigmentation0.88367259
94MP0010630_abnormal_cardiac_muscle0.88310725
95MP0005369_muscle_phenotype0.88029647
96MP0004233_abnormal_muscle_weight0.87853943
97MP0001188_hyperpigmentation0.85806509
98MP0003718_maternal_effect0.85026866
99MP0004130_abnormal_muscle_cell0.83955447
100MP0002234_abnormal_pharynx_morphology0.83283279
101MP0004215_abnormal_myocardial_fiber0.80225652
102MP0001286_abnormal_eye_development0.80172969
103MP0002060_abnormal_skin_morphology0.80048495
104MP0001929_abnormal_gametogenesis0.78247553
105MP0002429_abnormal_blood_cell0.78069306
106MP0002697_abnormal_eye_size0.77934038
107MP0002111_abnormal_tail_morphology0.76621193
108MP0009278_abnormal_bone_marrow0.75520774
109MP0005075_abnormal_melanosome_morpholog0.75227351
110MP0002006_tumorigenesis0.74638464
111MP0003252_abnormal_bile_duct0.73953792
112MP0000432_abnormal_head_morphology0.73894064
113MP0000598_abnormal_liver_morphology0.72676696
114MP0000428_abnormal_craniofacial_morphol0.72558701
115MP0000685_abnormal_immune_system0.72524735
116MP0003566_abnormal_cell_adhesion0.72213682
117MP0000569_abnormal_digit_pigmentation0.72119471
118MP0003283_abnormal_digestive_organ0.71903617
119MP0005501_abnormal_skin_physiology0.71791548
120MP0005666_abnormal_adipose_tissue0.71059205
121MP0002009_preneoplasia0.70948891
122MP0010030_abnormal_orbit_morphology0.70697419
123MP0010234_abnormal_vibrissa_follicle0.70468652
124MP0005384_cellular_phenotype0.69761604
125MP0001191_abnormal_skin_condition0.69534692
126MP0005621_abnormal_cell_physiology0.68965871
127MP0001216_abnormal_epidermal_layer0.68555437
128MP0000858_altered_metastatic_potential0.68268446
129MP0005319_abnormal_enzyme/_coenzyme0.67766863
130MP0000627_abnormal_mammary_gland0.66796258
131MP0004134_abnormal_chest_morphology0.66603050
132MP0000653_abnormal_sex_gland0.66326623
133MP0000762_abnormal_tongue_morphology0.66148347
134MP0005220_abnormal_exocrine_pancreas0.66133366
135MP0005023_abnormal_wound_healing0.65869904
136MP0009672_abnormal_birth_weight0.65016136
137MP0000477_abnormal_intestine_morphology0.64871593
138MP0001145_abnormal_male_reproductive0.64281185
139MP0003935_abnormal_craniofacial_develop0.64012310
140MP0001119_abnormal_female_reproductive0.63634865
141MP0001293_anophthalmia0.63487664
142MP0002332_abnormal_exercise_endurance0.63053454
143MP0001881_abnormal_mammary_gland0.62726368
144MP0008775_abnormal_heart_ventricle0.62619746
145MP0001873_stomach_inflammation0.61918132
146MP0008877_abnormal_DNA_methylation0.61716689
147MP0002210_abnormal_sex_determination0.60671742
148MP0000716_abnormal_immune_system0.60664823
149MP0003699_abnormal_female_reproductive0.56826414
150MP0000377_abnormal_hair_follicle0.56141960
151MP0003119_abnormal_digestive_system0.55362861

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.01810946
2Abnormal number of erythroid precursors (HP:0012131)4.85118667
3Muscle fiber inclusion bodies (HP:0100299)4.20724669
4Exercise-induced muscle cramps (HP:0003710)4.07079856
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.00124409
6Reticulocytopenia (HP:0001896)3.97283228
7Nemaline bodies (HP:0003798)3.73084498
8Neoplasm of the adrenal cortex (HP:0100641)3.64314754
9Rhabdomyolysis (HP:0003201)3.55667922
10Ulnar deviation of the wrist (HP:0003049)3.43989508
11Oral leukoplakia (HP:0002745)3.37557140
12Volvulus (HP:0002580)3.30166553
13Embryonal renal neoplasm (HP:0011794)3.27365315
14Birth length less than 3rd percentile (HP:0003561)3.19793824
15Nephroblastoma (Wilms tumor) (HP:0002667)3.18571091
16Myoglobinuria (HP:0002913)3.12312762
17Calcaneovalgus deformity (HP:0001848)3.12162556
18Myopathic facies (HP:0002058)3.07846471
19Aplastic anemia (HP:0001915)3.05797612
20Progressive muscle weakness (HP:0003323)3.05459586
21Distal arthrogryposis (HP:0005684)3.04731973
22Pallor (HP:0000980)3.02817072
23B lymphocytopenia (HP:0010976)2.93566299
24Colon cancer (HP:0003003)2.92809040
25Short middle phalanx of the 5th finger (HP:0004220)2.92806692
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.92413344
27Multiple enchondromatosis (HP:0005701)2.83183805
28Deformed tarsal bones (HP:0008119)2.82918129
29Pancreatic islet-cell hyperplasia (HP:0004510)2.82322036
30Selective tooth agenesis (HP:0001592)2.79633586
31Neoplasm of the adrenal gland (HP:0100631)2.76442823
32Exercise-induced myalgia (HP:0003738)2.74243588
33Macrocytic anemia (HP:0001972)2.73304069
34Type 1 muscle fiber predominance (HP:0003803)2.67961819
35Duodenal stenosis (HP:0100867)2.63772035
36Small intestinal stenosis (HP:0012848)2.63772035
37Abnormality of methionine metabolism (HP:0010901)2.63615812
38Ependymoma (HP:0002888)2.55301963
39Abnormality of reticulocytes (HP:0004312)2.54350603
40Glioma (HP:0009733)2.51690321
41Breast carcinoma (HP:0003002)2.51403624
42Abnormality of the calcaneus (HP:0008364)2.50557540
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49307476
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49307476
45Abnormality of B cell number (HP:0010975)2.42624495
46Abnormal biliary tract morphology (HP:0012440)2.42567616
47Abnormal lung lobation (HP:0002101)2.41040179
48Areflexia of lower limbs (HP:0002522)2.40150164
49Abnormality of chromosome stability (HP:0003220)2.39591599
50Neoplasm of the small intestine (HP:0100833)2.35123641
51Thrombocytosis (HP:0001894)2.34924058
52Breast hypoplasia (HP:0003187)2.33271975
53Increased connective tissue (HP:0009025)2.32602044
54Round ear (HP:0100830)2.26526881
55Rhabdomyosarcoma (HP:0002859)2.25828559
56Hypobetalipoproteinemia (HP:0003563)2.25371299
57Absent thumb (HP:0009777)2.25146184
58Acute myeloid leukemia (HP:0004808)2.24890865
59Astrocytoma (HP:0009592)2.22038079
60Abnormality of the astrocytes (HP:0100707)2.22038079
61Abnormality of the duodenum (HP:0002246)2.21137708
62Clubbing of toes (HP:0100760)2.21027383
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20575585
64Uterine neoplasm (HP:0010784)2.19768214
65Trismus (HP:0000211)2.17995183
66Abnormality of the preputium (HP:0100587)2.17622919
67Myelodysplasia (HP:0002863)2.16017985
68Megaloblastic anemia (HP:0001889)2.15816028
69Thyroiditis (HP:0100646)2.15796391
70Difficulty running (HP:0009046)2.13973885
71Hypoglycemic coma (HP:0001325)2.13200994
72Hypoglycemic seizures (HP:0002173)2.13105754
73Abnormality of the pancreatic islet cells (HP:0006476)2.11053478
74Abnormality of endocrine pancreas physiology (HP:0012093)2.11053478
75Ovarian neoplasm (HP:0100615)2.10252096
76Syringomyelia (HP:0003396)2.10123728
77Spinal cord lesions (HP:0100561)2.10123728
78Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.09954779
79Abnormality of the labia minora (HP:0012880)2.08975867
80Cafe-au-lait spot (HP:0000957)2.08109598
81Sloping forehead (HP:0000340)2.07669057
82Chromsome breakage (HP:0040012)2.06507969
83Medulloblastoma (HP:0002885)2.06113020
84Pelvic girdle muscle weakness (HP:0003749)2.06099305
85Muscle hypertrophy of the lower extremities (HP:0008968)2.05229409
86Hyperinsulinemic hypoglycemia (HP:0000825)2.04317633
87Basal cell carcinoma (HP:0002671)2.04165104
88Asymmetry of the thorax (HP:0001555)2.04091588
89Abnormality of serum amino acid levels (HP:0003112)2.02256392
90Hepatic necrosis (HP:0002605)2.01277101
91Papillary thyroid carcinoma (HP:0002895)2.00464674
92Increased intramyocellular lipid droplets (HP:0012240)1.99442888
93Curly hair (HP:0002212)1.99279455
94Increased serum ferritin (HP:0003281)1.99006926
95Hyperalaninemia (HP:0003348)1.98543696
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98543696
97Abnormality of alanine metabolism (HP:0010916)1.98543696
98Increased muscle lipid content (HP:0009058)1.98361629
99Squamous cell carcinoma (HP:0002860)1.98291097
100Thyroid carcinoma (HP:0002890)1.98221921
101Agnosia (HP:0010524)1.97519795
102Biliary tract neoplasm (HP:0100574)1.97154327
103Symptomatic seizures (HP:0011145)1.95587978
104Gastrointestinal carcinoma (HP:0002672)1.95295894
105Malignant gastrointestinal tract tumors (HP:0006749)1.95295894
106Meckel diverticulum (HP:0002245)1.94099399
107Clitoromegaly (HP:0000057)1.93332187
108Absent phalangeal crease (HP:0006109)1.92968514
109Angiofibromas (HP:0010615)1.92868288
110Adenoma sebaceum (HP:0009720)1.92868288
111Subaortic stenosis (HP:0001682)1.91986777
112Abnormality of the left ventricular outflow tract (HP:0011103)1.91986777
113Rough bone trabeculation (HP:0100670)1.91733020
114Increased serum lactate (HP:0002151)1.90965678
115Transitional cell carcinoma of the bladder (HP:0006740)1.90734897
116Abnormality of the ileum (HP:0001549)1.89751798
117Microretrognathia (HP:0000308)1.89397358
118Missing ribs (HP:0000921)1.88659593
119Pancytopenia (HP:0001876)1.88019743
120Abnormal hemoglobin (HP:0011902)1.88014559
121Hypoplasia of the thymus (HP:0000778)1.87656636
122Calf muscle hypertrophy (HP:0008981)1.86821714
123Muscle fiber splitting (HP:0003555)1.85986703
124Sensory axonal neuropathy (HP:0003390)1.85690652
125Carpal bone hypoplasia (HP:0001498)1.85023322
126Meningioma (HP:0002858)1.84114672
127Hepatocellular necrosis (HP:0001404)1.83641465
128Neoplasm of the pancreas (HP:0002894)1.83482820
129Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.83169602
130Neoplasm of the rectum (HP:0100743)1.83096538
131Progressive external ophthalmoplegia (HP:0000590)1.82832672
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.82361447
133Microvesicular hepatic steatosis (HP:0001414)1.82061761
134Nausea (HP:0002018)1.81753408
135Reduced antithrombin III activity (HP:0001976)1.80673442
136Absent radius (HP:0003974)1.80118390
137Abnormal auditory evoked potentials (HP:0006958)1.79851308
13811 pairs of ribs (HP:0000878)1.79819275
139Muscle stiffness (HP:0003552)1.79741096
140Abnormality of the anterior horn cell (HP:0006802)1.78870481
141Degeneration of anterior horn cells (HP:0002398)1.78870481
142Increased nuchal translucency (HP:0010880)1.78797889
143Abnormality of chromosome segregation (HP:0002916)1.78145806
144Poikiloderma (HP:0001029)1.77065536
145Termporal pattern (HP:0011008)1.76402592
146Insidious onset (HP:0003587)1.76402592
147Ventricular tachycardia (HP:0004756)1.75588419
148Choanal atresia (HP:0000453)1.75069301
149Difficulty climbing stairs (HP:0003551)1.75024688
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74842541
151Abnormality of iron homeostasis (HP:0011031)1.74667157
152Triphalangeal thumb (HP:0001199)1.74075525
153Dicarboxylic aciduria (HP:0003215)1.74030405
154Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74030405
155Reticulocytosis (HP:0001923)1.73951001
156Short palpebral fissure (HP:0012745)1.73686422
157Bladder neoplasm (HP:0009725)1.73594516
158Bladder carcinoma (HP:0002862)1.73594516
159Abnormality of pyrimidine metabolism (HP:0004353)1.73569559
160Arteriovenous malformation (HP:0100026)1.73428480
161Ankyloglossia (HP:0010296)1.72624515
162Premature ovarian failure (HP:0008209)1.71153271
163Deep philtrum (HP:0002002)1.70418175
164Ragged-red muscle fibers (HP:0003200)1.70398544
165Combined immunodeficiency (HP:0005387)1.70146271
166Spastic diplegia (HP:0001264)1.70122236
167Exercise intolerance (HP:0003546)1.69055321
168Ectopic kidney (HP:0000086)1.68868492
169Abnormality of the hip-girdle musculature (HP:0001445)1.68502513
170Abnormality of the musculature of the pelvis (HP:0001469)1.68502513
171Long clavicles (HP:0000890)1.68152751
172Fair hair (HP:0002286)1.68151561
173Neoplasm of the colon (HP:0100273)1.68056190
174Bifid tongue (HP:0010297)1.67767057
175Uterine leiomyosarcoma (HP:0002891)1.67696758
176Leiomyosarcoma (HP:0100243)1.67696758
177Abnormal foot bone ossification (HP:0010675)1.67475322
178Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67205271
179Absent eyebrow (HP:0002223)1.66871072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.83683184
2CDC73.10577584
3NME23.00440308
4EIF2AK12.91635837
5MST42.82122763
6BUB12.67741346
7PKN22.57115806
8TAF12.49863768
9NEK12.47441020
10NEK22.45685210
11ACVR1B2.40661363
12PBK2.33270821
13TTN2.11644890
14BMPR1B2.06649514
15OBSCN2.05868666
16STK391.93127355
17MAP2K31.92025623
18TTK1.91887630
19FRK1.90425625
20RPS6KB21.90071300
21SRPK11.89559965
22TRIB31.87490113
23BRSK21.86723893
24BCKDK1.82949129
25NUAK11.82657117
26EEF2K1.80352798
27ERBB31.75298484
28FLT31.72874536
29SCYL21.64355022
30TNIK1.64004038
31DYRK31.59693051
32CDK41.59247927
33PDK41.53904801
34PDK31.53904801
35TLK11.48239829
36AURKB1.47849717
37EIF2AK31.46970705
38STK101.46727182
39PLK11.44326096
40VRK11.43325950
41LATS11.42614336
42STK38L1.42503762
43CDK71.38873950
44NME11.38048160
45LRRK21.32543671
46STK41.30097026
47RPS6KA41.29159106
48MAP3K101.27269516
49MAP3K81.26149310
50TRIM281.25055830
51PIM21.24407806
52ATR1.21743843
53STK161.21373755
54MAPKAPK31.20629226
55CDK121.20462679
56MAP3K111.20218701
57CDK61.11030068
58PNCK1.08917448
59MET1.07887872
60PLK21.07806497
61TESK21.06141412
62PIM11.05414707
63CHEK21.02534282
64TSSK60.98158679
65PLK40.92788241
66MKNK10.90207318
67VRK20.88419355
68GRK10.83273851
69TGFBR10.83093173
70STK30.82958600
71OXSR10.82839172
72AURKA0.82780038
73MAP3K30.82636364
74ZAK0.82354389
75CHEK10.81981449
76MAP4K10.81722614
77PDK20.81502589
78PASK0.81372278
79KDR0.80825547
80MST1R0.80465512
81BRD40.79764226
82STK240.79567775
83ILK0.78991658
84CSNK1G10.78747039
85FGFR20.77021147
86FGFR10.76681949
87EPHA20.75734771
88NEK90.74279364
89PIK3CG0.74136389
90MKNK20.73992288
91ERBB40.70960470
92PAK40.69306134
93MAP3K60.68420255
94ATM0.67828975
95MELK0.66980306
96MAP3K20.66919054
97BCR0.66704433
98MAP3K120.66622781
99BRSK10.66312486
100WNK30.65464558
101NLK0.63858794
102MAPK110.61236169
103TEC0.60423682
104TYK20.58987581
105CSNK2A20.56896328
106CDK20.56822931
107BMPR20.56592884
108MAP3K40.55964837
109SMG10.54647079
110MAP3K140.53693701
111WNK40.52851296
112RPS6KB10.52478240
113CDK90.51827531
114PLK30.50987923
115CSNK2A10.50622590
116AKT20.49670347
117YES10.47139021
118CLK10.46871530
119CAMK1G0.46177296
120TRPM70.45320100
121RAF10.44969542
122CSNK1E0.43220081
123ZAP700.40821793
124MAP3K50.40410676
125BTK0.39692384
126PHKG20.39584800
127PHKG10.39584800
128CSF1R0.39557040
129TGFBR20.39302585
130MTOR0.38878491
131MAP2K60.38748556
132AKT30.36909555
133MAP3K70.36371248
134PINK10.36309687
135RPS6KA50.36060432
136PAK10.35346103
137EIF2AK20.34849545
138PAK20.33880592
139PRKCI0.33784817
140JAK30.33599755
141PRKG20.32618773
142MAPKAPK50.32396152
143DYRK1B0.31711456
144CDK10.30606405
145ALK0.30275722

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56139998
2Ribosome_Homo sapiens_hsa030103.84969910
3Mismatch repair_Homo sapiens_hsa034303.77909250
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07223882
5Spliceosome_Homo sapiens_hsa030402.64021116
6Homologous recombination_Homo sapiens_hsa034402.59077005
7One carbon pool by folate_Homo sapiens_hsa006702.58577157
8RNA transport_Homo sapiens_hsa030132.56830761
9Base excision repair_Homo sapiens_hsa034102.54978616
10Proteasome_Homo sapiens_hsa030502.45164883
11Nucleotide excision repair_Homo sapiens_hsa034202.43550095
12RNA polymerase_Homo sapiens_hsa030202.38502730
13Pyrimidine metabolism_Homo sapiens_hsa002402.16558930
14Cell cycle_Homo sapiens_hsa041102.15714558
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12238413
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88657286
17Non-homologous end-joining_Homo sapiens_hsa034501.72475855
18Fanconi anemia pathway_Homo sapiens_hsa034601.66693268
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65194860
20RNA degradation_Homo sapiens_hsa030181.63921160
21p53 signaling pathway_Homo sapiens_hsa041151.50562220
22Folate biosynthesis_Homo sapiens_hsa007901.46962622
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42559361
24Biosynthesis of amino acids_Homo sapiens_hsa012301.40869503
25Systemic lupus erythematosus_Homo sapiens_hsa053221.38355561
26Carbon metabolism_Homo sapiens_hsa012001.31894415
27Sulfur relay system_Homo sapiens_hsa041221.31728678
28Selenocompound metabolism_Homo sapiens_hsa004501.26756762
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.24401130
30Pentose phosphate pathway_Homo sapiens_hsa000301.23731208
31mRNA surveillance pathway_Homo sapiens_hsa030151.14665610
32Basal transcription factors_Homo sapiens_hsa030221.14318778
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12958861
34Purine metabolism_Homo sapiens_hsa002301.04361769
35Steroid biosynthesis_Homo sapiens_hsa001000.97937570
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95550606
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92503521
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89831626
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89498007
40Vitamin digestion and absorption_Homo sapiens_hsa049770.89254724
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87925581
42Herpes simplex infection_Homo sapiens_hsa051680.86204411
43Propanoate metabolism_Homo sapiens_hsa006400.85724091
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85471655
45Epstein-Barr virus infection_Homo sapiens_hsa051690.84562300
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.84256058
47Viral carcinogenesis_Homo sapiens_hsa052030.83727654
48TGF-beta signaling pathway_Homo sapiens_hsa043500.83580843
49Antigen processing and presentation_Homo sapiens_hsa046120.80778982
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80297822
51Sulfur metabolism_Homo sapiens_hsa009200.78714947
52Parkinsons disease_Homo sapiens_hsa050120.76953858
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.76941605
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75759818
55Small cell lung cancer_Homo sapiens_hsa052220.70674642
56Fatty acid elongation_Homo sapiens_hsa000620.70527837
57Adherens junction_Homo sapiens_hsa045200.70425576
58Glutathione metabolism_Homo sapiens_hsa004800.68327791
59Retinol metabolism_Homo sapiens_hsa008300.67837015
60Legionellosis_Homo sapiens_hsa051340.67820028
61Thyroid cancer_Homo sapiens_hsa052160.65914917
62Huntingtons disease_Homo sapiens_hsa050160.65288128
63Galactose metabolism_Homo sapiens_hsa000520.64767710
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63231634
65Protein export_Homo sapiens_hsa030600.61966088
66Pyruvate metabolism_Homo sapiens_hsa006200.61352587
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.59928762
68Prostate cancer_Homo sapiens_hsa052150.59624034
69Fatty acid degradation_Homo sapiens_hsa000710.59382240
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58050839
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57861943
72Fructose and mannose metabolism_Homo sapiens_hsa000510.53830740
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53626522
74Fatty acid metabolism_Homo sapiens_hsa012120.51029678
75Hippo signaling pathway_Homo sapiens_hsa043900.50627893
76Tight junction_Homo sapiens_hsa045300.50418943
77Arginine and proline metabolism_Homo sapiens_hsa003300.50350053
78HTLV-I infection_Homo sapiens_hsa051660.50282803
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48080731
80Melanoma_Homo sapiens_hsa052180.44794516
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.44651226
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43571040
83Fat digestion and absorption_Homo sapiens_hsa049750.43413949
84Colorectal cancer_Homo sapiens_hsa052100.43172530
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41815862
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41450096
87Starch and sucrose metabolism_Homo sapiens_hsa005000.41275216
88Butanoate metabolism_Homo sapiens_hsa006500.40753438
89Viral myocarditis_Homo sapiens_hsa054160.40576954
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40540218
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40101620
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39765354
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.39490474
94Apoptosis_Homo sapiens_hsa042100.38473500
95Fatty acid biosynthesis_Homo sapiens_hsa000610.37626106
96Arginine biosynthesis_Homo sapiens_hsa002200.37565190
97Oxidative phosphorylation_Homo sapiens_hsa001900.36922477
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36614861
99Acute myeloid leukemia_Homo sapiens_hsa052210.35732675
100Metabolic pathways_Homo sapiens_hsa011000.35643094
101MicroRNAs in cancer_Homo sapiens_hsa052060.34643703
102Oocyte meiosis_Homo sapiens_hsa041140.34420688
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33576726
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.33458592
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32788885
106HIF-1 signaling pathway_Homo sapiens_hsa040660.31933546
107N-Glycan biosynthesis_Homo sapiens_hsa005100.30915471
108Primary immunodeficiency_Homo sapiens_hsa053400.30609338
109Caffeine metabolism_Homo sapiens_hsa002320.30607428
110Measles_Homo sapiens_hsa051620.30458577
111Bladder cancer_Homo sapiens_hsa052190.30320320
112mTOR signaling pathway_Homo sapiens_hsa041500.30232189
113Hepatitis B_Homo sapiens_hsa051610.29635477
114Proteoglycans in cancer_Homo sapiens_hsa052050.29422433
115Wnt signaling pathway_Homo sapiens_hsa043100.29287715
116Sphingolipid metabolism_Homo sapiens_hsa006000.29149171
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28546513
118Alcoholism_Homo sapiens_hsa050340.28019200
119Lysine degradation_Homo sapiens_hsa003100.27540487
120AMPK signaling pathway_Homo sapiens_hsa041520.27052259
121Chronic myeloid leukemia_Homo sapiens_hsa052200.26318532
122Vitamin B6 metabolism_Homo sapiens_hsa007500.26133619
123Hematopoietic cell lineage_Homo sapiens_hsa046400.23968107
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23874452
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23819173
126beta-Alanine metabolism_Homo sapiens_hsa004100.23061973
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22997359
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22019360
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21432638
130Peroxisome_Homo sapiens_hsa041460.19492692
131Renin-angiotensin system_Homo sapiens_hsa046140.18714563
132Influenza A_Homo sapiens_hsa051640.18620752
133Alzheimers disease_Homo sapiens_hsa050100.17660206

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