CARNS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system, respectively (Drozak et al., 2010 [PubMed 20097752]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.94760869
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.87558125
3synaptic vesicle maturation (GO:0016188)6.79313537
4glutamate secretion (GO:0014047)6.23142131
5long-chain fatty acid biosynthetic process (GO:0042759)6.17402495
6ensheathment of neurons (GO:0007272)6.14402814
7axon ensheathment (GO:0008366)6.14402814
8myelination (GO:0042552)6.05674004
9myelin maintenance (GO:0043217)6.04924352
10synaptic vesicle exocytosis (GO:0016079)5.84598022
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.84336056
12creatine metabolic process (GO:0006600)5.64778316
13cellular potassium ion homeostasis (GO:0030007)5.51897199
14negative regulation of protein localization to cell surface (GO:2000009)5.34610764
15regulation of synaptic vesicle exocytosis (GO:2000300)5.32771662
16regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23399933
17sodium ion export (GO:0071436)5.08413900
18amyloid precursor protein metabolic process (GO:0042982)4.83936102
19establishment of mitochondrion localization (GO:0051654)4.81014846
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76849960
21sensory perception of smell (GO:0007608)4.74221507
22regulation of synaptic vesicle transport (GO:1902803)4.67944700
23response to methylmercury (GO:0051597)4.65371257
24cholesterol biosynthetic process (GO:0006695)4.57608149
25membrane tubulation (GO:0097320)4.56193514
26neurotransmitter secretion (GO:0007269)4.55242763
27amino acid import (GO:0043090)4.47035334
28neuronal ion channel clustering (GO:0045161)4.41717322
29regulation of neuronal synaptic plasticity (GO:0048168)4.36513377
30cerebellar granule cell differentiation (GO:0021707)4.34502405
31positive regulation of synapse maturation (GO:0090129)4.28853569
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.18847494
33locomotory exploration behavior (GO:0035641)4.16636314
34potassium ion homeostasis (GO:0055075)4.15240076
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.10542670
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.06892371
37sterol biosynthetic process (GO:0016126)4.06287586
38negative regulation of neurotransmitter transport (GO:0051589)4.02632126
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.02202175
40regulation of collateral sprouting (GO:0048670)4.01539426
41positive regulation of oligodendrocyte differentiation (GO:0048714)3.98452908
42regulation of lipoprotein metabolic process (GO:0050746)3.97362613
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.97243969
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82695141
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80460029
46postsynaptic membrane organization (GO:0001941)3.80319385
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.80040350
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.73864332
49regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.72804832
50neurotransmitter transport (GO:0006836)3.72392509
51photoreceptor cell differentiation (GO:0046530)3.71637128
52eye photoreceptor cell differentiation (GO:0001754)3.71637128
53vocalization behavior (GO:0071625)3.69840405
54fatty-acyl-CoA biosynthetic process (GO:0046949)3.66729387
55fatty-acyl-CoA metabolic process (GO:0035337)3.64468166
56negative regulation of neurotransmitter secretion (GO:0046929)3.64375317
57regulation of ARF protein signal transduction (GO:0032012)3.63613784
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62427784
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.61531691
60response to lipoprotein particle (GO:0055094)3.60898185
61regulation of voltage-gated calcium channel activity (GO:1901385)3.52429505
62isoprenoid biosynthetic process (GO:0008299)3.50371784
63cell communication by electrical coupling (GO:0010644)3.50059092
64regulation of synapse maturation (GO:0090128)3.49579520
65regulation of synaptic plasticity (GO:0048167)3.48129523
66regulation of neurotransmitter levels (GO:0001505)3.47352556
67exploration behavior (GO:0035640)3.45209440
68regulation of glutamate receptor signaling pathway (GO:1900449)3.44067722
69thioester biosynthetic process (GO:0035384)3.41472730
70acyl-CoA biosynthetic process (GO:0071616)3.41472730
71neuromuscular process controlling balance (GO:0050885)3.39521761
72positive regulation of dendritic spine development (GO:0060999)3.39290869
73acidic amino acid transport (GO:0015800)3.36211839
74cerebellar Purkinje cell differentiation (GO:0021702)3.35494664
75astrocyte development (GO:0014002)3.33055449
76neuromuscular synaptic transmission (GO:0007274)3.31466757
77oligodendrocyte differentiation (GO:0048709)3.31385115
78membrane depolarization during action potential (GO:0086010)3.31135692
79regulation of neurotransmitter secretion (GO:0046928)3.29421345
80synaptic transmission, glutamatergic (GO:0035249)3.28985670
81cellular sodium ion homeostasis (GO:0006883)3.28196557
82import into cell (GO:0098657)3.28006978
83amyloid precursor protein catabolic process (GO:0042987)3.27020808
84L-amino acid import (GO:0043092)3.25854947
85regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25032565
86positive regulation of membrane potential (GO:0045838)3.22714512
87regulation of synapse structural plasticity (GO:0051823)3.22535346
88GPI anchor biosynthetic process (GO:0006506)3.21391539
89protein palmitoylation (GO:0018345)3.19098014
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19064718
91substantia nigra development (GO:0021762)3.17646450
92negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16775416
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16393177
94regulation of dendritic spine development (GO:0060998)3.14995374
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13637266
96magnesium ion transport (GO:0015693)3.12578317
97regulation of neurotransmitter transport (GO:0051588)3.09420762
98regulation of relaxation of muscle (GO:1901077)3.07625352
99regulation of dendritic spine morphogenesis (GO:0061001)3.07213893
100long-term synaptic potentiation (GO:0060291)3.06073953
101negative regulation of inclusion body assembly (GO:0090084)3.05549603
102positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.05441767
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04880787
104glycerophospholipid catabolic process (GO:0046475)3.03331883
105long-term memory (GO:0007616)3.02445517
106neuron cell-cell adhesion (GO:0007158)3.02310753
107negative regulation of execution phase of apoptosis (GO:1900118)3.02036129
108regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.01119191
109peptidyl-tyrosine autophosphorylation (GO:0038083)3.01114026
110gamma-aminobutyric acid signaling pathway (GO:0007214)3.00977787
111neuron-neuron synaptic transmission (GO:0007270)3.00449737
112L-glutamate transport (GO:0015813)3.00173191
113preassembly of GPI anchor in ER membrane (GO:0016254)2.99692844
114response to redox state (GO:0051775)2.99453850
115GPI anchor metabolic process (GO:0006505)2.99143442
116negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.98659709
117neurotransmitter-gated ion channel clustering (GO:0072578)2.98087639
118positive regulation of Rap GTPase activity (GO:0032854)2.97411012
119membrane raft organization (GO:0031579)2.96901287
120striated muscle contraction (GO:0006941)2.96426954
121activation of protein kinase A activity (GO:0034199)2.96421523
122glutamate receptor signaling pathway (GO:0007215)2.95790155
123regulation of postsynaptic membrane potential (GO:0060078)2.95724266
124synaptic vesicle endocytosis (GO:0048488)2.93052975
125regulation of actin filament-based movement (GO:1903115)2.92959435
126regulation of vesicle fusion (GO:0031338)2.91307556
127Golgi to endosome transport (GO:0006895)2.91039071
128proline transport (GO:0015824)2.90166764
129protein localization to synapse (GO:0035418)2.89980759
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.89247440
131skeletal muscle contraction (GO:0003009)2.88987263
132asymmetric protein localization (GO:0008105)2.87782632
133membrane depolarization (GO:0051899)2.86363074
134regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86149146
135regulation of calcium ion transmembrane transport (GO:1903169)2.86149146
136nerve growth factor signaling pathway (GO:0038180)2.84150564
137sarcomere organization (GO:0045214)2.82795654
138peripheral nervous system axon ensheathment (GO:0032292)2.82071633
139myelination in peripheral nervous system (GO:0022011)2.82071633
140cellular response to epinephrine stimulus (GO:0071872)2.81935645
141response to epinephrine (GO:0071871)2.79797653
142positive regulation of glial cell differentiation (GO:0045687)2.78462519
143negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77152480
144axon development (GO:0061564)2.76547911
145very long-chain fatty acid metabolic process (GO:0000038)2.73602080
146adult walking behavior (GO:0007628)2.68688733
147response to inactivity (GO:0014854)2.68515511
148sensory perception of chemical stimulus (GO:0007606)2.68286617
149regulation of cell communication by electrical coupling (GO:0010649)2.67744035
150response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.67496368
151neurotransmitter uptake (GO:0001504)2.66381237
152negative regulation of potassium ion transmembrane transport (GO:1901380)2.65749978
153regulation of cytokine production involved in inflammatory response (GO:1900015)2.63110789
154potassium ion import (GO:0010107)2.62463392
155negative regulation of chemokine production (GO:0032682)2.58369052
156regulation of cardiac muscle cell contraction (GO:0086004)2.58061107
157apical protein localization (GO:0045176)2.57538401
158negative regulation of axonogenesis (GO:0050771)2.56921000
159tissue regeneration (GO:0042246)2.56703375
160positive regulation of gliogenesis (GO:0014015)2.56531467
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55510695
162mitochondrion transport along microtubule (GO:0047497)2.55510695
163cellular response to catecholamine stimulus (GO:0071870)2.55163467
164cellular response to monoamine stimulus (GO:0071868)2.55163467
165protein localization to endosome (GO:0036010)2.54775851
166response to catecholamine (GO:0071869)2.49383101
167response to monoamine (GO:0071867)2.49383101
168regulation of somitogenesis (GO:0014807)2.47601843
169presynaptic membrane organization (GO:0097090)2.47227728
170cortical actin cytoskeleton organization (GO:0030866)2.46621351
171detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.46009409
172detection of temperature stimulus involved in sensory perception (GO:0050961)2.46009409
173organ growth (GO:0035265)2.46007668
174myofibril assembly (GO:0030239)2.45630054
175glycosylceramide metabolic process (GO:0006677)2.44450685
176sarcoplasmic reticulum calcium ion transport (GO:0070296)2.44269624
177actin-myosin filament sliding (GO:0033275)2.44096811
178muscle filament sliding (GO:0030049)2.44096811
179neuronal action potential propagation (GO:0019227)2.43782947
180axon ensheathment in central nervous system (GO:0032291)11.3923593
181central nervous system myelination (GO:0022010)11.3923593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.06204598
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97196031
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.90891630
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.90248625
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.78419683
6REST_21632747_ChIP-Seq_MESCs_Mouse2.59961118
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.47856294
8TAF15_26573619_Chip-Seq_HEK293_Human2.46936272
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46641628
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.28395215
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.22169000
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95747591
13DROSHA_22980978_ChIP-Seq_HELA_Human1.89566473
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86709546
15GBX2_23144817_ChIP-Seq_PC3_Human1.83029036
16RUNX_20019798_ChIP-Seq_JUKART_Human1.79526679
17DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76062765
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.73763532
19KDM2B_26808549_Chip-Seq_K562_Human1.70676384
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68909808
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68788374
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67264261
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65077978
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.64078284
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62280479
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62055077
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60925738
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59766889
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59180562
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56768808
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55831142
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52946855
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52065205
34LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50928964
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49898446
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45636944
37AR_21572438_ChIP-Seq_LNCaP_Human1.45573781
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45135951
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43289475
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43289475
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.42848657
42ER_23166858_ChIP-Seq_MCF-7_Human1.41643410
43LXR_22292898_ChIP-Seq_THP-1_Human1.39424898
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36722759
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.36110433
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35194840
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33712171
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33474060
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.30962445
50GATA1_19941826_ChIP-Seq_K562_Human1.30949389
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30757215
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30462749
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29400286
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28965955
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27522163
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24694747
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24332181
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21745418
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.21686412
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21469583
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.21335336
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.20785548
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20606402
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20226293
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.20137258
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15843505
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15403326
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.14052454
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.14052454
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13966476
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13534508
72EOMES_21245162_ChIP-Seq_HESCs_Human1.13052916
73* OCT4_19829295_ChIP-Seq_ESCs_Human1.11642905
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11153309
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.10874448
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.09924296
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08959679
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08094973
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07731472
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05062931
81SMC4_20622854_ChIP-Seq_HELA_Human1.04562616
82STAT1_20625510_ChIP-Seq_HELA_Human1.03814442
83AR_19668381_ChIP-Seq_PC3_Human1.03090058
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02712596
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02560374
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00347679
87BP1_19119308_ChIP-ChIP_Hs578T_Human0.99832693
88SCL_19346495_ChIP-Seq_HPC-7_Human0.99769638
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99492968
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98269331
91EGR1_19032775_ChIP-ChIP_M12_Human0.98263842
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95886001
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95200264
94* OCT4_20526341_ChIP-Seq_ESCs_Human0.94886478
95* DPY_21335234_ChIP-Seq_ESCs_Mouse0.93381338
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93318409
97AHR_22903824_ChIP-Seq_MCF-7_Human0.92887335
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.91923302
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.91661321
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.91494682
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91147235
102P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90975596
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.90631831
104RING1B_27294783_Chip-Seq_NPCs_Mouse0.90114683
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89081432
106EED_16625203_ChIP-ChIP_MESCs_Mouse0.88244842
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88127593
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.87604684
109* KDM2B_26808549_Chip-Seq_JURKAT_Human0.87553929
110HTT_18923047_ChIP-ChIP_STHdh_Human0.87351799
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87085817
112GATA3_27048872_Chip-Seq_THYMUS_Human0.86797942
113* KDM2B_26808549_Chip-Seq_DND41_Human0.84157285
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83911629
115SOX2_19829295_ChIP-Seq_ESCs_Human0.83885144
116NANOG_19829295_ChIP-Seq_ESCs_Human0.83885144
117FOXH1_21741376_ChIP-Seq_ESCs_Human0.83621444
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.83568672
119SMAD4_21741376_ChIP-Seq_ESCs_Human0.83298880
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82605013
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.82587823
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81918036
123CREB1_26743006_Chip-Seq_LNCaP_Human0.81810240
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.81411650
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81187334
126KLF4_19829295_ChIP-Seq_ESCs_Human0.81137690
127NANOG_20526341_ChIP-Seq_ESCs_Human0.80759990
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80657866
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80604108
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80507404
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80315690
132TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.79748482
133STAT3_23295773_ChIP-Seq_U87_Human0.79619466
134P68_20966046_ChIP-Seq_HELA_Human0.79409495
135VDR_24763502_ChIP-Seq_THP-1_Human0.78026312
136SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.77533888
137* TCF7_22412390_ChIP-Seq_EML_Mouse0.77105686
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76751577
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76751577
140ZNF263_19887448_ChIP-Seq_K562_Human0.76292656
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76029828
142GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75091217
143* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74760714
144MYC_19915707_ChIP-ChIP_AK7_Human0.74382970
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.74348429
146SPI1_23127762_ChIP-Seq_K562_Human0.74192161
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74099329
148SA1_27219007_Chip-Seq_Bcells_Human0.74070817
149TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73942899
150CTCF_27219007_Chip-Seq_Bcells_Human0.73520167
151SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73072641
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73030966
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72665900
154MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.72271705
155TP53_16413492_ChIP-PET_HCT116_Human0.72047232
156TBL1_22424771_ChIP-Seq_293T_Human0.71858944
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70578012
158GATA1_26923725_Chip-Seq_HPCs_Mouse0.69671186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79700251
2MP0000920_abnormal_myelination5.42783661
3MP0003950_abnormal_plasma_membrane3.88001770
4MP0002063_abnormal_learning/memory/cond2.80282164
5MP0001984_abnormal_olfaction2.76614290
6MP0004036_abnormal_muscle_relaxation2.58376205
7MP0000751_myopathy2.55404118
8MP0000749_muscle_degeneration2.51295782
9MP0002837_dystrophic_cardiac_calcinosis2.42691757
10MP0001529_abnormal_vocalization2.42460983
11MP0003329_amyloid_beta_deposits2.32270951
12MP0000747_muscle_weakness2.30566541
13MP0004145_abnormal_muscle_electrophysio2.30322307
14MP0004270_analgesia2.29654938
15MP0003879_abnormal_hair_cell2.26358977
16MP0005409_darkened_coat_color2.26222557
17MP0003690_abnormal_glial_cell2.25754510
18MP0002272_abnormal_nervous_system2.22144534
19MP0002572_abnormal_emotion/affect_behav2.19210814
20MP0003880_abnormal_central_pattern2.16558682
21MP0009780_abnormal_chondrocyte_physiolo2.11444129
22MP0001501_abnormal_sleep_pattern2.08429542
23MP0001968_abnormal_touch/_nociception2.07674904
24MP0004742_abnormal_vestibular_system2.04361747
25MP0001905_abnormal_dopamine_level2.03762988
26MP0001485_abnormal_pinna_reflex2.02435757
27MP0003634_abnormal_glial_cell2.00835660
28MP0004142_abnormal_muscle_tone2.00778828
29MP0001486_abnormal_startle_reflex1.93309587
30MP0004381_abnormal_hair_follicle1.80787815
31MP0005410_abnormal_fertilization1.79709790
32MP0005451_abnormal_body_composition1.77316887
33MP0003806_abnormal_nucleotide_metabolis1.73205137
34MP0004084_abnormal_cardiac_muscle1.71488843
35MP0005330_cardiomyopathy1.70586705
36MP0004215_abnormal_myocardial_fiber1.62057356
37MP0002229_neurodegeneration1.61496186
38MP0004147_increased_porphyrin_level1.61202380
39MP0002735_abnormal_chemical_nociception1.60810077
40MP0008569_lethality_at_weaning1.54335853
41MP0002733_abnormal_thermal_nociception1.52969817
42MP0003137_abnormal_impulse_conducting1.52891728
43MP0002106_abnormal_muscle_physiology1.49370854
44MP0005423_abnormal_somatic_nervous1.48795684
45MP0004885_abnormal_endolymph1.47572818
46MP0002064_seizures1.45514093
47MP0004087_abnormal_muscle_fiber1.45350780
48MP0004811_abnormal_neuron_physiology1.45064338
49MP0001502_abnormal_circadian_rhythm1.40388725
50MP0003136_yellow_coat_color1.40358814
51MP0004043_abnormal_pH_regulation1.39318008
52MP0003633_abnormal_nervous_system1.37210762
53MP0003631_nervous_system_phenotype1.36944982
54MP0001440_abnormal_grooming_behavior1.35516288
55MP0003632_abnormal_nervous_system1.33170097
56MP0005167_abnormal_blood-brain_barrier1.32437301
57MP0005171_absent_coat_pigmentation1.31182497
58MP0005620_abnormal_muscle_contractility1.29489019
59MP0005646_abnormal_pituitary_gland1.26474269
60MP0005369_muscle_phenotype1.24171993
61MP0002972_abnormal_cardiac_muscle1.23718800
62MP0004484_altered_response_of1.23027772
63MP0002736_abnormal_nociception_after1.22093578
64MP0006082_CNS_inflammation1.21223994
65MP0000759_abnormal_skeletal_muscle1.21117477
66MP0003787_abnormal_imprinting1.17116129
67MP0000778_abnormal_nervous_system1.14742941
68MP0008260_abnormal_autophagy1.14718540
69MP0002557_abnormal_social/conspecific_i1.14559788
70MP0002734_abnormal_mechanical_nocicepti1.11281681
71MP0006036_abnormal_mitochondrial_physio1.10097543
72MP0010678_abnormal_skin_adnexa1.08766325
73MP0004085_abnormal_heartbeat1.08716275
74MP0000604_amyloidosis1.08577535
75MP0004134_abnormal_chest_morphology1.08137132
76MP0003075_altered_response_to1.06655764
77MP0004510_myositis1.06447994
78MP0001986_abnormal_taste_sensitivity1.05897193
79MP0001177_atelectasis1.05529181
80MP0005075_abnormal_melanosome_morpholog1.05321003
81MP0003656_abnormal_erythrocyte_physiolo1.05229273
82MP0002332_abnormal_exercise_endurance1.05014495
83MP0001346_abnormal_lacrimal_gland1.02502900
84MP0002822_catalepsy1.02045191
85MP0004185_abnormal_adipocyte_glucose1.00939547
86MP0001970_abnormal_pain_threshold1.00182677
87MP0000383_abnormal_hair_follicle0.99013912
88MP0000003_abnormal_adipose_tissue0.98415505
89MP0001851_eye_inflammation0.98090721
90MP0005623_abnormal_meninges_morphology0.97497389
91MP0002882_abnormal_neuron_morphology0.97445744
92MP0003646_muscle_fatigue0.95577943
93MP0003045_fibrosis0.94573604
94MP0003635_abnormal_synaptic_transmissio0.93529631
95MP0009745_abnormal_behavioral_response0.92962006
96MP0003123_paternal_imprinting0.92319153
97MP0002067_abnormal_sensory_capabilities0.92058725
98MP0001790_abnormal_immune_system0.92003061
99MP0005387_immune_system_phenotype0.92003061
100MP0008775_abnormal_heart_ventricle0.91622333
101MP0004130_abnormal_muscle_cell0.91366768
102MP0002066_abnormal_motor_capabilities/c0.90012129
103MP0004924_abnormal_behavior0.89435397
104MP0005386_behavior/neurological_phenoty0.89435397
105MP0006276_abnormal_autonomic_nervous0.88657139
106MP0002752_abnormal_somatic_nervous0.87818378
107MP0000372_irregular_coat_pigmentation0.87156440
108MP0005551_abnormal_eye_electrophysiolog0.86831750
109MP0000955_abnormal_spinal_cord0.85511885
110MP0000462_abnormal_digestive_system0.84636589
111MP0010630_abnormal_cardiac_muscle0.84524433
112MP0001348_abnormal_lacrimal_gland0.84354469
113MP0002152_abnormal_brain_morphology0.83378565
114MP0002933_joint_inflammation0.82810301
115MP0000685_abnormal_immune_system0.82440144
116MP0005645_abnormal_hypothalamus_physiol0.81591944
117MP0009046_muscle_twitch0.80690639
118MP0002269_muscular_atrophy0.80207568
119MP0005375_adipose_tissue_phenotype0.80196554
120MP0008874_decreased_physiological_sensi0.79434369
121MP0000465_gastrointestinal_hemorrhage0.79299473
122MP0002184_abnormal_innervation0.78604766
123MP0005535_abnormal_body_temperature0.78604530
124MP0005584_abnormal_enzyme/coenzyme_acti0.78572085
125MP0001661_extended_life_span0.76592225
126MP0000750_abnormal_muscle_regeneration0.73797444
127MP0001299_abnormal_eye_distance/0.72949605
128MP0001963_abnormal_hearing_physiology0.72559694
129MP0005166_decreased_susceptibility_to0.72271196
130MP0005165_increased_susceptibility_to0.68954255
131MP0003122_maternal_imprinting0.58479569
132MP0002638_abnormal_pupillary_reflex0.57724149
133MP0000733_abnormal_muscle_development0.54090654
134MP0002069_abnormal_eating/drinking_beha0.53366581
135MP0001943_abnormal_respiration0.51645818
136MP0004233_abnormal_muscle_weight0.49743632

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.37155038
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.37155038
3Focal motor seizures (HP:0011153)5.13006080
4Neurofibrillary tangles (HP:0002185)4.79716003
5Termporal pattern (HP:0011008)4.66626853
6Insidious onset (HP:0003587)4.66626853
7Onion bulb formation (HP:0003383)4.65415075
8Abnormality of the corticospinal tract (HP:0002492)4.58974527
9Peripheral hypomyelination (HP:0007182)4.43323938
10Muscle hypertrophy of the lower extremities (HP:0008968)4.41553606
11Focal seizures (HP:0007359)4.32900086
12Muscle fiber splitting (HP:0003555)4.16876122
13Abnormality of binocular vision (HP:0011514)4.11462250
14Diplopia (HP:0000651)4.11462250
15Febrile seizures (HP:0002373)4.06597430
16Retinal dysplasia (HP:0007973)4.02877718
17Parakeratosis (HP:0001036)4.00975495
18Calf muscle hypertrophy (HP:0008981)3.87838971
19Segmental peripheral demyelination/remyelination (HP:0003481)3.80398405
20Epileptic encephalopathy (HP:0200134)3.71804604
21Type 1 muscle fiber predominance (HP:0003803)3.70695557
22Atonic seizures (HP:0010819)3.64614976
23Hyporeflexia of lower limbs (HP:0002600)3.64303063
24Obstructive sleep apnea (HP:0002870)3.45014204
25Cerebral inclusion bodies (HP:0100314)3.43937894
26Foot dorsiflexor weakness (HP:0009027)3.41364115
27Distal arthrogryposis (HP:0005684)3.39107815
28Spastic gait (HP:0002064)3.37047885
29Supranuclear gaze palsy (HP:0000605)3.32089031
30Sudden death (HP:0001699)3.30218926
31Bundle branch block (HP:0011710)3.29296291
32Abnormality of the foot musculature (HP:0001436)3.26399362
33Ankle clonus (HP:0011448)3.24574388
34Exercise-induced myalgia (HP:0003738)3.23210388
35Sensory axonal neuropathy (HP:0003390)3.18742172
36Generalized tonic-clonic seizures (HP:0002069)3.14668408
37Visual hallucinations (HP:0002367)3.13287433
38Myopathic facies (HP:0002058)3.10209089
39Postural instability (HP:0002172)3.09535430
40Leukodystrophy (HP:0002415)3.06523800
41Abnormality of glycolysis (HP:0004366)3.04600275
42Increased serum pyruvate (HP:0003542)3.04600275
43Difficulty running (HP:0009046)3.02963783
44Fetal akinesia sequence (HP:0001989)2.95574829
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.91572700
46Papilledema (HP:0001085)2.91489521
47Stridor (HP:0010307)2.88189912
48Cerebral hemorrhage (HP:0001342)2.86252916
49Urinary bladder sphincter dysfunction (HP:0002839)2.85232880
50Slow saccadic eye movements (HP:0000514)2.85228031
51Akinesia (HP:0002304)2.80052681
52Gowers sign (HP:0003391)2.79555889
53Cerebral hypomyelination (HP:0006808)2.79031823
54Pheochromocytoma (HP:0002666)2.78356977
55Hemiplegia (HP:0002301)2.73752062
56Abnormal auditory evoked potentials (HP:0006958)2.73673416
57Dysmetria (HP:0001310)2.72413258
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69910844
59Abnormal eating behavior (HP:0100738)2.69665881
60Absence seizures (HP:0002121)2.66948346
61Tetraplegia (HP:0002445)2.64132508
62Clonus (HP:0002169)2.58659743
63Progressive cerebellar ataxia (HP:0002073)2.57629038
64Rigidity (HP:0002063)2.57367197
65Abnormality of the calf musculature (HP:0001430)2.57073812
66Neuroendocrine neoplasm (HP:0100634)2.55967336
67Spastic tetraparesis (HP:0001285)2.54407395
68Prolonged QT interval (HP:0001657)2.53841546
69Lower limb amyotrophy (HP:0007210)2.49469491
70Dialeptic seizures (HP:0011146)2.47366712
71Hammertoe (HP:0001765)2.45534368
72EMG: neuropathic changes (HP:0003445)2.44890810
73Axonal loss (HP:0003447)2.42911289
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.42492191
75Rapidly progressive (HP:0003678)2.41312610
76Truncal ataxia (HP:0002078)2.41114480
77Atrial fibrillation (HP:0005110)2.40204428
78Heart block (HP:0012722)2.40100832
79Decreased motor nerve conduction velocity (HP:0003431)2.39760139
80Limb dystonia (HP:0002451)2.39700626
81EMG: myopathic abnormalities (HP:0003458)2.37487487
82Poor eye contact (HP:0000817)2.35637041
83Acute necrotizing encephalopathy (HP:0006965)2.34050936
84Torticollis (HP:0000473)2.34035958
85Annular pancreas (HP:0001734)2.32085308
86Dysdiadochokinesis (HP:0002075)2.30652845
87Steppage gait (HP:0003376)2.30406380
88Depression (HP:0000716)2.30349113
89Mutism (HP:0002300)2.30087281
90Neuronal loss in central nervous system (HP:0002529)2.29716246
91Impaired vibration sensation in the lower limbs (HP:0002166)2.29395475
92Frequent falls (HP:0002359)2.27797290
93Increased circulating renin level (HP:0000848)2.27647455
94Urinary urgency (HP:0000012)2.27190750
95Intention tremor (HP:0002080)2.25963042
96Ulnar deviation of the wrist (HP:0003049)2.25314975
97Methylmalonic acidemia (HP:0002912)2.24944098
98Ventricular fibrillation (HP:0001663)2.24110754
99Ulnar claw (HP:0001178)2.22976968
100Scanning speech (HP:0002168)2.22615010
101Lower limb muscle weakness (HP:0007340)2.22252113
102Choreoathetosis (HP:0001266)2.21907561
103Syncope (HP:0001279)2.21811255
104Delusions (HP:0000746)2.20841056
105Abnormal atrioventricular conduction (HP:0005150)2.20687005
106Type II lissencephaly (HP:0007260)2.19067551
107Abnormality of skeletal muscle fiber size (HP:0012084)2.18451277
108Exercise-induced muscle cramps (HP:0003710)2.16613518
109Primary atrial arrhythmia (HP:0001692)2.16128346
110Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.15697909
111Sleep apnea (HP:0010535)2.15127982
112Autoamputation (HP:0001218)2.13554793
113Hepatocellular necrosis (HP:0001404)2.12943746
114Muscle fiber inclusion bodies (HP:0100299)2.12155840
115Bradykinesia (HP:0002067)2.11569017
116Anxiety (HP:0000739)2.10928882
117Ventricular tachycardia (HP:0004756)2.09555439
118Anteriorly placed anus (HP:0001545)2.09213513
119Myoglobinuria (HP:0002913)2.07062785
120Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.07036323
121Nemaline bodies (HP:0003798)2.06947492
122Supraventricular tachycardia (HP:0004755)2.05687910
123Abnormality of the periventricular white matter (HP:0002518)2.04268459
124Rhabdomyolysis (HP:0003201)2.04101525
125Abnormal mitochondria in muscle tissue (HP:0008316)2.03374937
126Myokymia (HP:0002411)2.02681235
127Hypoplasia of the iris (HP:0007676)2.01714095
128Acute encephalopathy (HP:0006846)2.00073311
129Status epilepticus (HP:0002133)1.99658316
130Increased variability in muscle fiber diameter (HP:0003557)1.99310891
131T lymphocytopenia (HP:0005403)1.98555084
132Muscle stiffness (HP:0003552)1.97961522
133Supraventricular arrhythmia (HP:0005115)1.97783274
134Dilated cardiomyopathy (HP:0001644)1.97706441
135Premature skin wrinkling (HP:0100678)1.97659132
136Gastrointestinal stroma tumor (HP:0100723)1.96517020
137Mitochondrial inheritance (HP:0001427)1.95672259
138Clumsiness (HP:0002312)1.95018230
139Impaired social interactions (HP:0000735)1.94446938
140Abnormal social behavior (HP:0012433)1.94446938
141Action tremor (HP:0002345)1.94302750
142Progressive macrocephaly (HP:0004481)1.93588098
143Lipoatrophy (HP:0100578)1.93165072
144Spastic paraparesis (HP:0002313)1.92892170
145Infantile muscular hypotonia (HP:0008947)1.90990806
146Duplicated collecting system (HP:0000081)1.88323226
147Alacrima (HP:0000522)1.83893020
148Large for gestational age (HP:0001520)1.83682640
149Neck muscle weakness (HP:0000467)1.83488730
150Partial agenesis of the corpus callosum (HP:0001338)1.82264815
151Absent septum pellucidum (HP:0001331)1.82120006
152Abnormality of the left ventricular outflow tract (HP:0011103)1.80318964
153Subaortic stenosis (HP:0001682)1.80318964
154Abnormality of T cell number (HP:0011839)1.79942855
155Hypoplastic pelvis (HP:0008839)1.79313753
156Distal sensory impairment (HP:0002936)1.79063536
157Myotonia (HP:0002486)1.78297847
158Round ear (HP:0100830)1.77224328
159CNS hypomyelination (HP:0003429)1.76976998
160Hepatic necrosis (HP:0002605)1.76793463
161Loss of speech (HP:0002371)1.76313265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.10918154
2EPHB14.49364600
3EPHA43.94711562
4OXSR13.49865551
5NTRK33.44922606
6MAPKAPK53.37150779
7MARK13.15009122
8DAPK23.10880832
9PHKG12.82711031
10PHKG22.82711031
11PKN12.76432116
12WNK42.46408467
13NTRK22.27669272
14WNK12.22002509
15PRKD32.15328716
16CLK12.09991055
17CAMKK11.95108464
18RIPK41.86594720
19MAP3K91.80023821
20PRPF4B1.76514588
21MUSK1.73791867
22CAMK2D1.71382103
23MAP4K11.69301324
24UHMK11.68589254
25MINK11.65723063
26CDK191.61566783
27OBSCN1.58869274
28CSNK1A1L1.56493410
29RIPK11.55328284
30CAMK2B1.52729286
31TTN1.52185297
32PAK31.51441169
33ROCK21.51165028
34CSNK1G31.50590085
35MARK21.43725049
36KSR21.43597049
37PNCK1.43126417
38PRKD11.38521621
39FGFR21.28650697
40CSNK1G11.25096100
41BCR1.19073946
42PRKCQ1.18304162
43GRK51.17755208
44TNK21.17544647
45TESK21.16448287
46LIMK11.16225649
47MAPK131.16132573
48PBK1.15543423
49MET1.15487474
50ITK1.12387760
51SGK4941.11365695
52SGK2231.11365695
53MST41.10667208
54PLK21.09196484
55SGK21.07543490
56SGK31.03680092
57TRPM71.03329064
58FGR1.02759784
59CAMK2G1.02687238
60CSNK1G20.96106262
61DMPK0.96059488
62MAPK150.95981628
63CAMK1G0.93197711
64TNIK0.93022081
65LATS20.92451802
66MAP3K130.92195842
67MAP3K70.92108402
68MAPK100.90450782
69MAPK120.89702971
70ALK0.89391520
71PIK3CA0.89324291
72CSF1R0.89282314
73SGK10.86990428
74NTRK10.84454174
75DYRK1A0.84182157
76STK380.80670977
77DAPK10.80328009
78CAMK2A0.78542847
79RPS6KA50.77857286
80CDK150.77448683
81CAMK40.77071793
82MAP3K110.76429995
83GRK70.74905065
84PRKCG0.73399381
85CDK180.72554407
86HIPK20.72489600
87CDK11A0.70970345
88MAP2K40.70381597
89ILK0.68656158
90PDPK10.67849069
91BTK0.66003349
92RPS6KA30.65014880
93PRKCH0.64889963
94BMPR20.64872268
95LCK0.62374344
96DYRK20.62256533
97ICK0.58554038
98CASK0.58174675
99PRKD20.57347514
100MYLK0.56826565
101TRIB30.56090061
102NEK60.55814496
103FYN0.55711214
104PDK10.55444078
105MAP3K10.55282052
106BLK0.53536950
107CAMKK20.53132478
108STK40.51697808
109CDK50.50838464
110STK110.50461960
111CSK0.50380453
112MAPK70.50138106
113PRKCE0.48273703
114FES0.48096891
115ROCK10.47995153
116PRKACB0.47612831
117TYRO30.47203196
118PAK60.46857222
119TXK0.44457544
120MAP2K60.44258738
121SYK0.42433933
122PRKG10.41959439
123STK100.41532527
124PRKCZ0.40920912
125MARK30.40754227
126MAPK40.40217379
127GRK60.39135357
128MOS0.39065716
129MAP2K10.37782930
130RET0.36971486
131CSNK1D0.36498457
132SIK20.36449424
133JAK10.36167915
134CCNB10.36075838
135KSR10.35687271
136BRAF0.35047560
137PIK3CG0.34738677
138MAPKAPK20.34520043
139JAK20.34179194
140DAPK30.34124924
141BRSK10.33877993
142RAF10.32301334
143GSK3A0.31757335
144CAMK10.31398932
145PINK10.30869635
146KIT0.30786105
147HCK0.30737077
148PRKACA0.30253399
149ARAF0.27895699
150CDK140.27732763
151PRKAA20.27192571
152NLK0.27063745
153LRRK20.26614724

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.35857158
2Fatty acid elongation_Homo sapiens_hsa000624.95883173
3Steroid biosynthesis_Homo sapiens_hsa001004.10718424
4Synaptic vesicle cycle_Homo sapiens_hsa047213.29039522
5Nicotine addiction_Homo sapiens_hsa050333.05469996
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03263937
7Long-term potentiation_Homo sapiens_hsa047202.89388007
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.86334340
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83925827
10Ether lipid metabolism_Homo sapiens_hsa005652.64475990
11Olfactory transduction_Homo sapiens_hsa047402.53462566
12Amphetamine addiction_Homo sapiens_hsa050312.43019484
13Insulin secretion_Homo sapiens_hsa049112.38134005
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36235615
15Oxidative phosphorylation_Homo sapiens_hsa001902.26597110
16Parkinsons disease_Homo sapiens_hsa050122.25628273
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.23330080
18Alzheimers disease_Homo sapiens_hsa050101.89193802
19Cardiac muscle contraction_Homo sapiens_hsa042601.81604383
20Sphingolipid metabolism_Homo sapiens_hsa006001.62616123
21Primary immunodeficiency_Homo sapiens_hsa053401.60308887
22Propanoate metabolism_Homo sapiens_hsa006401.53246420
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48198309
24Linoleic acid metabolism_Homo sapiens_hsa005911.37887908
25Dilated cardiomyopathy_Homo sapiens_hsa054141.32611489
26Sulfur metabolism_Homo sapiens_hsa009201.32417067
27Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.31217137
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30260469
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30127881
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26137423
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23188943
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22462742
33Estrogen signaling pathway_Homo sapiens_hsa049151.18100183
34Fatty acid metabolism_Homo sapiens_hsa012121.17380118
35Glioma_Homo sapiens_hsa052141.11837120
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10889243
37Morphine addiction_Homo sapiens_hsa050321.09324460
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07840191
39Sphingolipid signaling pathway_Homo sapiens_hsa040711.06711901
40Protein export_Homo sapiens_hsa030601.06410569
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06271219
42Circadian rhythm_Homo sapiens_hsa047101.05935187
43Vitamin B6 metabolism_Homo sapiens_hsa007501.04753389
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03917386
45Glucagon signaling pathway_Homo sapiens_hsa049221.02145882
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02073241
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01383480
48Butanoate metabolism_Homo sapiens_hsa006501.01319381
49Bile secretion_Homo sapiens_hsa049761.00296045
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00134682
51Glutamatergic synapse_Homo sapiens_hsa047241.00092640
52Serotonergic synapse_Homo sapiens_hsa047260.99025430
53Axon guidance_Homo sapiens_hsa043600.98746121
54Melanogenesis_Homo sapiens_hsa049160.95080840
55Gap junction_Homo sapiens_hsa045400.94265990
56Gastric acid secretion_Homo sapiens_hsa049710.92169724
57B cell receptor signaling pathway_Homo sapiens_hsa046620.91988104
58GABAergic synapse_Homo sapiens_hsa047270.91786385
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89535164
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.89353898
61Circadian entrainment_Homo sapiens_hsa047130.85867794
62Huntingtons disease_Homo sapiens_hsa050160.85381174
63ErbB signaling pathway_Homo sapiens_hsa040120.85097569
64Thyroid hormone synthesis_Homo sapiens_hsa049180.84642675
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.84444278
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84212527
67Ovarian steroidogenesis_Homo sapiens_hsa049130.83074148
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78963458
69Renal cell carcinoma_Homo sapiens_hsa052110.78448269
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76875493
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76647217
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76179770
73Insulin signaling pathway_Homo sapiens_hsa049100.76082298
74Prion diseases_Homo sapiens_hsa050200.71273421
75Arginine biosynthesis_Homo sapiens_hsa002200.69665212
76T cell receptor signaling pathway_Homo sapiens_hsa046600.69397177
77Rap1 signaling pathway_Homo sapiens_hsa040150.69158866
78Dorso-ventral axis formation_Homo sapiens_hsa043200.67639760
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.66895272
80Arachidonic acid metabolism_Homo sapiens_hsa005900.66697936
81Collecting duct acid secretion_Homo sapiens_hsa049660.66340951
82Cholinergic synapse_Homo sapiens_hsa047250.66240630
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65958411
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65808124
85Dopaminergic synapse_Homo sapiens_hsa047280.65658597
86Ras signaling pathway_Homo sapiens_hsa040140.65197443
87Salivary secretion_Homo sapiens_hsa049700.64325124
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63718665
89Oocyte meiosis_Homo sapiens_hsa041140.61499854
90Choline metabolism in cancer_Homo sapiens_hsa052310.61355091
91Type II diabetes mellitus_Homo sapiens_hsa049300.60706678
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.60255867
93Pyruvate metabolism_Homo sapiens_hsa006200.60188586
94Autoimmune thyroid disease_Homo sapiens_hsa053200.59613620
95Chemokine signaling pathway_Homo sapiens_hsa040620.58820838
96Renin secretion_Homo sapiens_hsa049240.58394550
97* Histidine metabolism_Homo sapiens_hsa003400.58304515
98Taste transduction_Homo sapiens_hsa047420.57692994
99cAMP signaling pathway_Homo sapiens_hsa040240.57464527
100Platelet activation_Homo sapiens_hsa046110.55724834
101Tight junction_Homo sapiens_hsa045300.55411978
102Calcium signaling pathway_Homo sapiens_hsa040200.54905801
103AMPK signaling pathway_Homo sapiens_hsa041520.54384564
104Endocytosis_Homo sapiens_hsa041440.54079688
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.52820056
106Nitrogen metabolism_Homo sapiens_hsa009100.52753822
107Cocaine addiction_Homo sapiens_hsa050300.52258317
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52034788
109Peroxisome_Homo sapiens_hsa041460.52008426
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48002295
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47802704
112mTOR signaling pathway_Homo sapiens_hsa041500.47102528
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46259348
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46134957
115Pancreatic secretion_Homo sapiens_hsa049720.45883121
116ABC transporters_Homo sapiens_hsa020100.45529923
117Vibrio cholerae infection_Homo sapiens_hsa051100.41797511
118Long-term depression_Homo sapiens_hsa047300.40991548
119Hematopoietic cell lineage_Homo sapiens_hsa046400.40270694
120Oxytocin signaling pathway_Homo sapiens_hsa049210.39458102
121MAPK signaling pathway_Homo sapiens_hsa040100.38554371
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36794235
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36681265
124Viral myocarditis_Homo sapiens_hsa054160.36290207
125Fatty acid biosynthesis_Homo sapiens_hsa000610.35644719
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34756605
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34118223
128Salmonella infection_Homo sapiens_hsa051320.33546664
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33298223
130GnRH signaling pathway_Homo sapiens_hsa049120.32999855
131* Arginine and proline metabolism_Homo sapiens_hsa003300.32834044
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32499746
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.32294415
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31465038
135Inositol phosphate metabolism_Homo sapiens_hsa005620.30040046
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28886738
137Non-small cell lung cancer_Homo sapiens_hsa052230.28594950
138Phototransduction_Homo sapiens_hsa047440.28484526
139Metabolic pathways_Homo sapiens_hsa011000.28479362
140Fatty acid degradation_Homo sapiens_hsa000710.27204240
141HIF-1 signaling pathway_Homo sapiens_hsa040660.26665645
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26589575
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24358223
144VEGF signaling pathway_Homo sapiens_hsa043700.23782352

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