CARTPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)7.86770130
2negative regulation of DNA repair (GO:0045738)7.50152237
3thyroid hormone generation (GO:0006590)7.00249121
4thyroid hormone metabolic process (GO:0042403)5.91214643
5negative regulation of amino acid transport (GO:0051956)5.43620996
6regulation of glutamate secretion (GO:0014048)4.96381364
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83169458
8cell migration in hindbrain (GO:0021535)4.68212963
9negative regulation of microtubule polymerization (GO:0031115)4.62248815
10regulation of feeding behavior (GO:0060259)4.58259697
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57692548
12cellular potassium ion homeostasis (GO:0030007)4.51545371
13urinary tract smooth muscle contraction (GO:0014848)4.44767161
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.42522445
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.33117359
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.32641801
17chaperone-mediated protein transport (GO:0072321)4.30426835
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.29734357
19negative regulation of DNA recombination (GO:0045910)4.28953485
20membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.27992064
21regulation of glucocorticoid secretion (GO:2000849)4.27779511
22respiratory system process (GO:0003016)4.25058622
23dopaminergic neuron differentiation (GO:0071542)4.22815928
24axonal fasciculation (GO:0007413)4.22047712
25positive regulation of amino acid transport (GO:0051957)4.17645888
26regulation of short-term neuronal synaptic plasticity (GO:0048172)4.15359439
27neuron recognition (GO:0008038)4.12760149
28oxygen transport (GO:0015671)4.12075084
29response to gravity (GO:0009629)4.10458886
30positive regulation of membrane potential (GO:0045838)4.10013950
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08334903
32ATP synthesis coupled proton transport (GO:0015986)4.05196431
33energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05196431
34membrane repolarization (GO:0086009)4.04505917
35synaptic vesicle exocytosis (GO:0016079)4.03335697
36behavioral fear response (GO:0001662)3.95208647
37behavioral defense response (GO:0002209)3.95208647
38regulation of glutamate receptor signaling pathway (GO:1900449)3.93341530
39protein localization to synapse (GO:0035418)3.92687771
40regulation of vesicle fusion (GO:0031338)3.90912662
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.89663125
42dendritic spine morphogenesis (GO:0060997)3.88671505
43synaptic vesicle maturation (GO:0016188)3.84233990
44behavioral response to cocaine (GO:0048148)3.82609850
45neuron cell-cell adhesion (GO:0007158)3.81696140
46presynaptic membrane assembly (GO:0097105)3.79189197
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.76526203
48cerebellar Purkinje cell differentiation (GO:0021702)3.76492460
49membrane repolarization during action potential (GO:0086011)3.76041382
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.75720331
51inner mitochondrial membrane organization (GO:0007007)3.71998776
52vocalization behavior (GO:0071625)3.70145029
53cellular response to ATP (GO:0071318)3.69927528
54regulation of synaptic vesicle exocytosis (GO:2000300)3.69803068
55protein insertion into membrane (GO:0051205)3.69352679
56positive regulation of synapse assembly (GO:0051965)3.68485654
57respiratory electron transport chain (GO:0022904)3.66588350
58startle response (GO:0001964)3.66332809
59response to pheromone (GO:0019236)3.66171550
60negative regulation of hormone biosynthetic process (GO:0032353)3.66032397
61electron transport chain (GO:0022900)3.63290214
62cerebellar granule cell differentiation (GO:0021707)3.60249855
63neurotransmitter secretion (GO:0007269)3.59907292
64neuron remodeling (GO:0016322)3.59224054
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55565929
66glutamate receptor signaling pathway (GO:0007215)3.55325269
67regulation of corticosteroid hormone secretion (GO:2000846)3.51070458
68membrane depolarization during action potential (GO:0086010)3.50174820
69* regulation of appetite (GO:0032098)3.50167132
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49814971
71mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.47979523
72response to dietary excess (GO:0002021)3.47669419
73fear response (GO:0042596)3.46757980
74locomotory exploration behavior (GO:0035641)3.42958956
75neuromuscular process controlling posture (GO:0050884)3.41937628
76presynaptic membrane organization (GO:0097090)3.39084740
77gamma-aminobutyric acid transport (GO:0015812)3.38291084
78negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38189705
79synaptic transmission, glutamatergic (GO:0035249)3.37890209
80regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35996307
81sleep (GO:0030431)3.34860852
82inositol phosphate-mediated signaling (GO:0048016)3.34793424
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.32537745
84* positive regulation of amine transport (GO:0051954)3.32089501
85response to histamine (GO:0034776)3.29552397
86regulation of protein kinase A signaling (GO:0010738)3.26635715
87activation of protein kinase A activity (GO:0034199)3.26065953
88growth hormone secretion (GO:0030252)3.25755787
89negative regulation of hormone metabolic process (GO:0032351)3.24054896
90* neuropeptide signaling pathway (GO:0007218)3.22181395
91neuron-neuron synaptic transmission (GO:0007270)3.21307873
92pyrimidine nucleobase catabolic process (GO:0006208)3.21283132
93regulation of synapse assembly (GO:0051963)3.19148351
94negative regulation of amine transport (GO:0051953)3.17660735
95regulation of glucocorticoid metabolic process (GO:0031943)3.17195384
96positive regulation of potassium ion transmembrane transport (GO:1901381)3.15813054
97neurotransmitter transport (GO:0006836)3.14743832
98potassium ion import (GO:0010107)3.11808645
99positive regulation of meiosis (GO:0045836)3.10994903
100regulation of synaptic vesicle transport (GO:1902803)3.10526485
101regulation of neuronal synaptic plasticity (GO:0048168)3.10401564
102axon extension (GO:0048675)3.08267191
103calcium-mediated signaling using intracellular calcium source (GO:0035584)3.07782831
104mating behavior (GO:0007617)3.06655695
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04138625
106positive regulation of gastrulation (GO:2000543)3.02704785
107regulation of voltage-gated calcium channel activity (GO:1901385)3.00264016
108clathrin coat assembly (GO:0048268)2.99730840
109layer formation in cerebral cortex (GO:0021819)2.98074543
110regulation of amino acid transport (GO:0051955)2.96877157
111imidazole-containing compound metabolic process (GO:0052803)2.96797920
112artery smooth muscle contraction (GO:0014824)2.95322834
113potassium ion homeostasis (GO:0055075)2.94605821
114membrane depolarization (GO:0051899)2.93066273
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92966109
116positive regulation of dendritic spine development (GO:0060999)2.92770564
117regulation of phospholipid biosynthetic process (GO:0071071)2.92707980
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.91816800
119cerebellar Purkinje cell layer development (GO:0021680)2.91094327
120cell differentiation in hindbrain (GO:0021533)2.90430910
121proline transport (GO:0015824)2.90118989
122regulation of calcium ion-dependent exocytosis (GO:0017158)2.89745611
123tachykinin receptor signaling pathway (GO:0007217)2.89649723
124atrial cardiac muscle cell action potential (GO:0086014)2.88298592
125positive regulation of meiotic cell cycle (GO:0051446)2.88034390
126regulation of neurotransmitter levels (GO:0001505)2.87787450
127substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.86982283
128substrate-independent telencephalic tangential migration (GO:0021826)2.86982283
129regulation of dopamine secretion (GO:0014059)2.86184834
130energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.85389797
131ATP hydrolysis coupled proton transport (GO:0015991)2.85389797
132dopamine receptor signaling pathway (GO:0007212)2.85297340
133detection of light stimulus involved in visual perception (GO:0050908)2.85220929
134detection of light stimulus involved in sensory perception (GO:0050962)2.85220929
135social behavior (GO:0035176)2.84943767
136intraspecies interaction between organisms (GO:0051703)2.84943767
137cellular response to glucagon stimulus (GO:0071377)2.82531820
138exploration behavior (GO:0035640)2.82175995
139regulation of postsynaptic membrane potential (GO:0060078)2.82016942
140* feeding behavior (GO:0007631)2.81786991
141regulation of clathrin-mediated endocytosis (GO:2000369)2.81179813
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80603858
143positive regulation of action potential (GO:0045760)2.80433882
144glutamate secretion (GO:0014047)2.80430920
145regulation of double-strand break repair via homologous recombination (GO:0010569)2.79785825
146neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.79683213
147opioid receptor signaling pathway (GO:0038003)2.75602549
148dendrite development (GO:0016358)2.74913984
149neurofilament cytoskeleton organization (GO:0060052)2.74797439
150neurotransmitter catabolic process (GO:0042135)2.74613267
151synapse assembly (GO:0007416)2.73459302
152regulation of axon extension involved in axon guidance (GO:0048841)2.68482610
153dendrite morphogenesis (GO:0048813)2.66699601
154nerve growth factor signaling pathway (GO:0038180)2.65282423
155head development (GO:0060322)2.63063346
156nucleobase catabolic process (GO:0046113)2.62857679
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62714296
158protein localization to cilium (GO:0061512)2.61558586
159ionotropic glutamate receptor signaling pathway (GO:0035235)2.61063353
160regulation of axon guidance (GO:1902667)2.60059471
161forebrain neuron differentiation (GO:0021879)2.59592142
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58995415
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.57526709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85924754
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.16780745
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14522679
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14429044
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08366401
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01249965
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.95954390
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73832047
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69557204
10VDR_22108803_ChIP-Seq_LS180_Human2.66740491
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.66558642
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64855621
13GBX2_23144817_ChIP-Seq_PC3_Human2.63944745
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62354850
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62354850
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55894062
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55673163
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53300604
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50843264
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44361163
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.36809364
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.32379478
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.31902192
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23642944
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19399640
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03090629
27ZNF274_21170338_ChIP-Seq_K562_Hela1.97423300
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96348268
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.90802322
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.86965154
31RNF2_27304074_Chip-Seq_NSC_Mouse1.86023531
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84029098
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83302711
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79566768
35AR_21572438_ChIP-Seq_LNCaP_Human1.76593184
36DROSHA_22980978_ChIP-Seq_HELA_Human1.74661264
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71771751
38* P300_19829295_ChIP-Seq_ESCs_Human1.67095278
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66616260
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65889371
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63026239
42TAF15_26573619_Chip-Seq_HEK293_Human1.62553555
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61642968
44SMAD4_21799915_ChIP-Seq_A2780_Human1.60231541
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56349114
46CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.53795314
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53628122
48* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48199016
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44732418
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42968947
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.42754331
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.39696904
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.35631281
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34832231
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34502352
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33245191
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31929452
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31692044
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30662433
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27692449
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25831753
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.24710530
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22651791
64* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21272458
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15412679
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.14653615
67ZNF263_19887448_ChIP-Seq_K562_Human1.14172786
68RXR_22108803_ChIP-Seq_LS180_Human1.13436788
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13198633
70HTT_18923047_ChIP-ChIP_STHdh_Human1.12523769
71AHR_22903824_ChIP-Seq_MCF-7_Human1.11904893
72BCAT_22108803_ChIP-Seq_LS180_Human1.11616197
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10685186
74RUNX2_22187159_ChIP-Seq_PCA_Human1.10355653
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10266321
76* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09543524
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09257355
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09250811
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.08897338
80* AR_25329375_ChIP-Seq_VCAP_Human1.08840823
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.08267737
82CBP_20019798_ChIP-Seq_JUKART_Human1.08243359
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08243359
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08124387
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08124387
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05786795
87FUS_26573619_Chip-Seq_HEK293_Human1.05524423
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05290823
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05235311
90* ER_23166858_ChIP-Seq_MCF-7_Human1.05179356
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04597182
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02269232
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01081715
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00985972
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00845102
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00619959
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.00177844
98* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99878927
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99267544
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99183194
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.98882418
102* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97938244
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96639212
104* JUN_21703547_ChIP-Seq_K562_Human0.96576203
105TCF4_23295773_ChIP-Seq_U87_Human0.96325951
106POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.95689944
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95371497
108AR_19668381_ChIP-Seq_PC3_Human0.94347540
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94263543
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93994193
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93989588
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93029441
113SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92922727
114* IGF1R_20145208_ChIP-Seq_DFB_Human0.92836765
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92313525
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.91714601
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91388403
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91170879
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90971607
120REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90163610
121SOX2_19829295_ChIP-Seq_ESCs_Human0.89834272
122NANOG_19829295_ChIP-Seq_ESCs_Human0.89834272
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89072952
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88489358
125* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87529318
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.86922551
127TP53_18474530_ChIP-ChIP_U2OS_Human0.86304246
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82197826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.28953636
2MP0003880_abnormal_central_pattern4.18370012
3MP0006276_abnormal_autonomic_nervous3.82820772
4MP0005645_abnormal_hypothalamus_physiol3.49137102
5MP0004859_abnormal_synaptic_plasticity3.39010070
6MP0001968_abnormal_touch/_nociception3.30767164
7MP0003635_abnormal_synaptic_transmissio3.08392900
8MP0001984_abnormal_olfaction3.04757993
9MP0002064_seizures2.66182164
10MP0002063_abnormal_learning/memory/cond2.65950918
11MP0009745_abnormal_behavioral_response2.56069275
12MP0004270_analgesia2.54704296
13MP0003121_genomic_imprinting2.46014127
14MP0002572_abnormal_emotion/affect_behav2.45632853
15MP0001440_abnormal_grooming_behavior2.40552753
16MP0001188_hyperpigmentation2.39744756
17MP0001529_abnormal_vocalization2.26651488
18MP0000751_myopathy2.22264815
19MP0000681_abnormal_thyroid_gland2.19967818
20MP0009046_muscle_twitch2.17878627
21MP0004142_abnormal_muscle_tone2.17461806
22MP0002734_abnormal_mechanical_nocicepti2.15354222
23MP0002822_catalepsy2.12716241
24MP0005423_abnormal_somatic_nervous2.09730039
25MP0002733_abnormal_thermal_nociception2.00652810
26MP0002735_abnormal_chemical_nociception1.99538874
27MP0002272_abnormal_nervous_system1.96800609
28MP0002837_dystrophic_cardiac_calcinosis1.92457312
29MP0002557_abnormal_social/conspecific_i1.89874903
30MP0000778_abnormal_nervous_system1.89760523
31MP0004043_abnormal_pH_regulation1.88569767
32MP0005646_abnormal_pituitary_gland1.88502820
33MP0002184_abnormal_innervation1.88323342
34MP0003879_abnormal_hair_cell1.85526928
35MP0001970_abnormal_pain_threshold1.83758967
36MP0005386_behavior/neurological_phenoty1.79787577
37MP0004924_abnormal_behavior1.79787577
38MP0005083_abnormal_biliary_tract1.79739881
39MP0000383_abnormal_hair_follicle1.76370418
40MP0002067_abnormal_sensory_capabilities1.74417254
41MP0009379_abnormal_foot_pigmentation1.73969847
42MP0002909_abnormal_adrenal_gland1.73428972
43MP0008877_abnormal_DNA_methylation1.71885801
44MP0003123_paternal_imprinting1.65236599
45MP0003329_amyloid_beta_deposits1.59594790
46MP0001486_abnormal_startle_reflex1.58231686
47MP0006072_abnormal_retinal_apoptosis1.56976593
48MP0002876_abnormal_thyroid_physiology1.54563124
49MP0000631_abnormal_neuroendocrine_gland1.54247758
50MP0001905_abnormal_dopamine_level1.51116850
51MP0001501_abnormal_sleep_pattern1.47158830
52MP0001485_abnormal_pinna_reflex1.39759064
53MP0002736_abnormal_nociception_after1.38810903
54MP0010386_abnormal_urinary_bladder1.38313424
55MP0001502_abnormal_circadian_rhythm1.37993827
56MP0000566_synostosis1.30567215
57MP0003890_abnormal_embryonic-extraembry1.30413155
58MP0002882_abnormal_neuron_morphology1.30328149
59MP0004510_myositis1.30010615
60MP0004811_abnormal_neuron_physiology1.27730046
61MP0002638_abnormal_pupillary_reflex1.26631948
62MP0002066_abnormal_motor_capabilities/c1.25367327
63MP0010678_abnormal_skin_adnexa1.25043442
64MP0000538_abnormal_urinary_bladder1.20336699
65MP0008872_abnormal_physiological_respon1.15311579
66MP0002234_abnormal_pharynx_morphology1.14058500
67MP0003787_abnormal_imprinting1.13751808
68* MP0002069_abnormal_eating/drinking_beha1.11436530
69MP0002332_abnormal_exercise_endurance1.10496934
70MP0005409_darkened_coat_color1.09784847
71MP0000955_abnormal_spinal_cord1.09214198
72* MP0005448_abnormal_energy_balance1.09107428
73MP0003632_abnormal_nervous_system1.03509446
74MP0005551_abnormal_eye_electrophysiolog1.03300883
75MP0005379_endocrine/exocrine_gland_phen0.99582412
76MP0000747_muscle_weakness0.99058985
77MP0003959_abnormal_lean_body0.98141705
78MP0002152_abnormal_brain_morphology0.97630159
79MP0008260_abnormal_autophagy0.92753700
80MP0004145_abnormal_muscle_electrophysio0.92214958
81MP0001963_abnormal_hearing_physiology0.91318103
82MP0001348_abnormal_lacrimal_gland0.90189033
83MP0008995_early_reproductive_senescence0.87571683
84MP0003011_delayed_dark_adaptation0.86997340
85MP0008875_abnormal_xenobiotic_pharmacok0.86309230
86MP0000604_amyloidosis0.85889249
87MP0002751_abnormal_autonomic_nervous0.85639185
88MP0002752_abnormal_somatic_nervous0.85053800
89MP0000026_abnormal_inner_ear0.78394906
90MP0000013_abnormal_adipose_tissue0.78309063
91MP0003638_abnormal_response/metabolism_0.76792104
92MP0002163_abnormal_gland_morphology0.75444242
93MP0004133_heterotaxia0.74112383
94* MP0005452_abnormal_adipose_tissue0.73957338
95MP0003868_abnormal_feces_composition0.73139541
96MP0003137_abnormal_impulse_conducting0.72270731
97MP0001765_abnormal_ion_homeostasis0.72057040
98MP0004885_abnormal_endolymph0.71929858
99MP0003690_abnormal_glial_cell0.71043323
100MP0008569_lethality_at_weaning0.70956507
101MP0002938_white_spotting0.70894536
102MP0001177_atelectasis0.70666482
103MP0004085_abnormal_heartbeat0.69655989
104MP0005535_abnormal_body_temperature0.68304069
105MP0004742_abnormal_vestibular_system0.68046417
106MP0002229_neurodegeneration0.67924779
107MP0003948_abnormal_gas_homeostasis0.67836695
108MP0004215_abnormal_myocardial_fiber0.67637002
109MP0001666_abnormal_nutrient_absorption0.67481672
110MP0000462_abnormal_digestive_system0.67372073
111MP0001944_abnormal_pancreas_morphology0.66820895
112MP0005253_abnormal_eye_physiology0.66649653
113MP0003283_abnormal_digestive_organ0.65198400
114MP0001664_abnormal_digestion0.64203341
115MP0001943_abnormal_respiration0.64053465
116MP0003633_abnormal_nervous_system0.63905054
117* MP0002078_abnormal_glucose_homeostasis0.63873237
118MP0001727_abnormal_embryo_implantation0.63694321
119MP0002102_abnormal_ear_morphology0.61996227
120MP0005167_abnormal_blood-brain_barrier0.61347984
121MP0003938_abnormal_ear_development0.59687839
122MP0004858_abnormal_nervous_system0.59526364
123MP0010770_preweaning_lethality0.59396014
124MP0002082_postnatal_lethality0.59396014
125MP0003631_nervous_system_phenotype0.58631334
126MP0004883_abnormal_blood_vessel0.58039771
127MP0003634_abnormal_glial_cell0.57126758
128MP0000920_abnormal_myelination0.56677227

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)5.65735831
2Myokymia (HP:0002411)5.30332447
3Goiter (HP:0000853)5.28629076
4Failure to thrive in infancy (HP:0001531)4.94754416
5Thyroid-stimulating hormone excess (HP:0002925)4.64969112
6Focal seizures (HP:0007359)4.55110534
7Focal motor seizures (HP:0011153)4.50415080
8Pheochromocytoma (HP:0002666)4.14892260
9Abnormal eating behavior (HP:0100738)4.08526967
10Atonic seizures (HP:0010819)3.97468892
11Absence seizures (HP:0002121)3.94829870
12Neuroendocrine neoplasm (HP:0100634)3.78974362
13Poor suck (HP:0002033)3.57420538
14Abnormality of the labia minora (HP:0012880)3.52760136
15Oligomenorrhea (HP:0000876)3.48671277
16Acute necrotizing encephalopathy (HP:0006965)3.45586156
17Febrile seizures (HP:0002373)3.44480852
18Hypoglycemic seizures (HP:0002173)3.33744216
19Progressive cerebellar ataxia (HP:0002073)3.30120463
20Congenital sensorineural hearing impairment (HP:0008527)3.30070150
21Epileptic encephalopathy (HP:0200134)3.26775681
22Dialeptic seizures (HP:0011146)3.25155255
23Abnormality of the corticospinal tract (HP:0002492)3.19803218
24Visual hallucinations (HP:0002367)3.15367316
25Generalized tonic-clonic seizures (HP:0002069)3.14061381
26Hypoventilation (HP:0002791)3.09728836
27Abnormal mitochondria in muscle tissue (HP:0008316)3.09719031
28Narrow nasal bridge (HP:0000446)3.08816600
29Lipid accumulation in hepatocytes (HP:0006561)3.07588231
30Congenital stationary night blindness (HP:0007642)3.06172190
31Abnormal hair whorl (HP:0010721)3.05635502
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.01267949
33Degeneration of the lateral corticospinal tracts (HP:0002314)3.01267949
34Supranuclear gaze palsy (HP:0000605)2.99934134
35Progressive macrocephaly (HP:0004481)2.97454817
36Delayed epiphyseal ossification (HP:0002663)2.97300496
37Esotropia (HP:0000565)2.97160533
38Sleep apnea (HP:0010535)2.96960549
39Anxiety (HP:0000739)2.94027571
40Impaired vibration sensation in the lower limbs (HP:0002166)2.89322298
41Increased hepatocellular lipid droplets (HP:0006565)2.84340732
42Acute encephalopathy (HP:0006846)2.82311605
43Impaired pain sensation (HP:0007328)2.79127668
44Abnormality of pain sensation (HP:0010832)2.79127668
45Limb dystonia (HP:0002451)2.76804300
46Symptomatic seizures (HP:0011145)2.75700933
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.74160233
48Generalized hypotonia (HP:0001290)2.72890356
49Agitation (HP:0000713)2.70978229
50Spastic gait (HP:0002064)2.70837601
51Tented upper lip vermilion (HP:0010804)2.70583854
52Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.69844867
53Broad alveolar ridges (HP:0000187)2.69555999
54Mitochondrial inheritance (HP:0001427)2.65863954
55Molar tooth sign on MRI (HP:0002419)2.62173175
56Abnormality of midbrain morphology (HP:0002418)2.62173175
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55742494
58Mutism (HP:0002300)2.54514956
59Drooling (HP:0002307)2.52748396
60Hyperventilation (HP:0002883)2.51565372
61Hypothermia (HP:0002045)2.51488866
62Focal dystonia (HP:0004373)2.50337400
63Abnormality of cochlea (HP:0000375)2.50282038
64Truncal ataxia (HP:0002078)2.49413424
65Hyperthyroidism (HP:0000836)2.48467831
66Nephronophthisis (HP:0000090)2.43780944
67Pili torti (HP:0003777)2.39045995
68Thyroid carcinoma (HP:0002890)2.38085572
69Neurofibrillary tangles (HP:0002185)2.36461798
70Abnormal pancreas size (HP:0012094)2.36361127
71Excessive salivation (HP:0003781)2.33586556
72Broad-based gait (HP:0002136)2.33527948
73Optic disc pallor (HP:0000543)2.33263335
74Morphological abnormality of the pyramidal tract (HP:0002062)2.33143366
75Psychosis (HP:0000709)2.33128248
76Cerebral hemorrhage (HP:0001342)2.33069363
77Gait imbalance (HP:0002141)2.31673430
78Hyperparathyroidism (HP:0000843)2.31247919
79Prolonged QT interval (HP:0001657)2.30314373
80Termporal pattern (HP:0011008)2.30280224
81Insidious onset (HP:0003587)2.30280224
82Abnormal EKG (HP:0003115)2.28561535
83Akinesia (HP:0002304)2.25460439
84Abnormal pupillary function (HP:0007686)2.24029125
85Rimmed vacuoles (HP:0003805)2.23584139
86Shoulder girdle muscle weakness (HP:0003547)2.22316994
87Parakeratosis (HP:0001036)2.21615776
88Anosmia (HP:0000458)2.21228274
89Ankle clonus (HP:0011448)2.20813050
90Large eyes (HP:0001090)2.20478551
91Palpitations (HP:0001962)2.19918512
92Action tremor (HP:0002345)2.19820640
93Menstrual irregularities (HP:0000858)2.19005826
94Diaphragmatic weakness (HP:0009113)2.17727240
95Mild short stature (HP:0003502)2.16932661
96Prominent supraorbital ridges (HP:0000336)2.14389178
97Small epiphyses (HP:0010585)2.13125414
98Macroglossia (HP:0000158)2.12708799
99Abnormal ciliary motility (HP:0012262)2.12654147
100Hepatic necrosis (HP:0002605)2.11959012
101Cerebral edema (HP:0002181)2.11538234
102Specific learning disability (HP:0001328)2.11535223
103Chronic hepatic failure (HP:0100626)2.07802112
104Renal Fanconi syndrome (HP:0001994)2.07744528
105Amblyopia (HP:0000646)2.06572986
106Unilateral renal agenesis (HP:0000122)2.06392961
107Depression (HP:0000716)2.04870559
108Nasal speech (HP:0001611)2.04232037
109Neoplasm of the peripheral nervous system (HP:0100007)2.03013365
110Cerebral inclusion bodies (HP:0100314)2.02922720
111Testicular neoplasm (HP:0010788)2.02477398
112EEG with generalized epileptiform discharges (HP:0011198)2.02275822
113Urinary urgency (HP:0000012)2.02213740
114Leukodystrophy (HP:0002415)2.02107094
115Abnormality of macular pigmentation (HP:0008002)2.01633026
116Morphological abnormality of the inner ear (HP:0011390)2.01209163
117Hypsarrhythmia (HP:0002521)1.97875488
118Increased intramyocellular lipid droplets (HP:0012240)1.97491969
119Bronchomalacia (HP:0002780)1.96801596
120Epileptiform EEG discharges (HP:0011182)1.95971735
1213-Methylglutaconic aciduria (HP:0003535)1.94235563
122Large for gestational age (HP:0001520)1.93988273
123Palpebral edema (HP:0100540)1.93401593
124Increased muscle lipid content (HP:0009058)1.92692206
125Dysmetria (HP:0001310)1.92543747
126True hermaphroditism (HP:0010459)1.91099339
127Clonus (HP:0002169)1.90727038
128Status epilepticus (HP:0002133)1.90462783
129Cerebral aneurysm (HP:0004944)1.90223851
130Neonatal onset (HP:0003623)1.88159909
131Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87272159
132Increased serum pyruvate (HP:0003542)1.87167869
133Central scotoma (HP:0000603)1.86785078
134Intellectual disability, progressive (HP:0006887)1.86110835
135Dysdiadochokinesis (HP:0002075)1.84668923
136Diplopia (HP:0000651)1.84576711
137Abnormality of binocular vision (HP:0011514)1.84576711
138Hepatocellular necrosis (HP:0001404)1.83824800
139Shawl scrotum (HP:0000049)1.83798670
140Hypoplastic ischia (HP:0003175)1.83749836
141Generalized myoclonic seizures (HP:0002123)1.83513430
142Hypercortisolism (HP:0001578)1.83081919
143Tetraplegia (HP:0002445)1.82689168
144Labial hypoplasia (HP:0000066)1.82157753
145Ventricular fibrillation (HP:0001663)1.82059011
146Occipital encephalocele (HP:0002085)1.81996967
147Pancreatic fibrosis (HP:0100732)1.81828160
148Torticollis (HP:0000473)1.81021518
149Hoarse voice (HP:0001609)1.80760365
150Atrial fibrillation (HP:0005110)1.80603796
151Lower limb muscle weakness (HP:0007340)1.80402393
152Delayed gross motor development (HP:0002194)1.80342479
153Postural instability (HP:0002172)1.79700422
154Coarse facial features (HP:0000280)1.78679401
155Papilledema (HP:0001085)1.77069486
156Heterochromia iridis (HP:0001100)1.76584055
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76099009
158Craniofacial dystonia (HP:0012179)1.75383892
159Protruding tongue (HP:0010808)1.74622991
160Progressive inability to walk (HP:0002505)1.73830388
161Primary atrial arrhythmia (HP:0001692)1.73515677
162Sporadic (HP:0003745)1.73013099
163Increased CSF lactate (HP:0002490)1.72943271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.83599106
2TAOK34.73431228
3MAP3K124.59425783
4NTRK33.67001307
5PNCK2.99158309
6UHMK12.84874324
7MAP3K92.84510345
8NTRK22.68324664
9MAP2K42.46613195
10NME12.35712805
11WNK32.31416518
12MINK12.25226124
13MAPK132.22436206
14MAP3K42.18886266
15BMPR1B2.05127969
16CAMKK21.92569848
17PHKG11.88549227
18PHKG21.88549227
19PAK31.81756199
20CASK1.78205151
21FES1.70461441
22IRAK21.69747941
23PAK61.68504673
24CAMK1G1.65162834
25MAP2K71.62931740
26BCR1.55863855
27MAP3K61.54384079
28DYRK21.51794011
29TAF11.51021721
30CDK191.40924010
31CDK81.30005238
32TNIK1.26672233
33CDK51.24117985
34ARAF1.18714670
35MKNK21.18093470
36KSR11.11924560
37ACVR1B1.10171241
38PRKCG1.09249683
39CAMK2B1.08739682
40ADRBK11.07699016
41STK381.05686517
42PINK11.01884976
43CAMK2A0.98121317
44MAP3K110.96685712
45CSNK1G20.96428308
46LIMK10.95782968
47CDK140.95412344
48ALK0.94498158
49MAP2K60.94127701
50CDK180.94059808
51SIK30.92912876
52CAMK2G0.92852615
53CAMKK10.92711768
54ERBB30.90989659
55GRK50.90696451
56SGK2230.88274955
57SGK4940.88274955
58CDK150.87037452
59PLK20.86349127
60OXSR10.85755863
61MAPK40.85256399
62DYRK1A0.84101395
63GRK70.83820560
64CSNK1G30.81822111
65AKT30.80851253
66CAMK1D0.79227210
67CAMK10.79169328
68CDK11A0.76523535
69TGFBR10.76160880
70MAP3K50.76105154
71CAMK2D0.71578326
72SGK20.69252870
73DAPK10.67532546
74TYRO30.64429438
75FGFR20.60988995
76ADRBK20.60645718
77MARK20.60310904
78ZAK0.58679012
79DAPK20.58022968
80CSNK1A1L0.58000385
81SIK20.57826257
82EPHA40.57777555
83STK160.57200881
84TLK10.56596119
85LRRK20.54840891
86MAPK150.54203080
87GRK10.53239896
88INSRR0.52661091
89CSNK1G10.52654824
90PRKCZ0.50751799
91PRKD20.50473740
92LATS20.49546098
93MAP3K100.48766021
94PRKG20.48731368
95RIPK40.48648813
96MST1R0.48105541
97PKN10.47130063
98CSNK1E0.47074322
99MAP4K20.43551315
100SCYL20.43510796
101FYN0.43473107
102PRKACA0.43080440
103NTRK10.42207553
104RET0.41849817
105KSR20.41049224
106TSSK60.40989046
107BCKDK0.40209917
108PRKCE0.39771157
109CAMK40.39145679
110LMTK20.38947432
111TESK10.38237118
112PRKG10.38186745
113FRK0.38169569
114BMPR20.37916519
115MST40.37615136
116MAP2K10.36976758
117EPHB20.34719325
118PRKCB0.34367873
119PDK10.34083650
120DAPK30.33364256
121ROCK20.33218516
122SGK10.33019466
123PRKACG0.32816113
124MAPK90.32170087
125RPS6KA30.31740509
126IRAK10.31701845
127MOS0.31616874
128PAK20.31403129
129BRAF0.29692576
130MAP3K10.29216510
131MAPK120.28914065
132HIPK20.28661603
133TNK20.28593040
134TIE10.28532978

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15497947
2Oxidative phosphorylation_Homo sapiens_hsa001904.03318767
3Parkinsons disease_Homo sapiens_hsa050123.47834714
4GABAergic synapse_Homo sapiens_hsa047273.17090782
5Synaptic vesicle cycle_Homo sapiens_hsa047213.06318014
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79757941
7Olfactory transduction_Homo sapiens_hsa047402.66120310
8Alzheimers disease_Homo sapiens_hsa050102.65939262
9Morphine addiction_Homo sapiens_hsa050322.60515992
10Collecting duct acid secretion_Homo sapiens_hsa049662.57260304
11Huntingtons disease_Homo sapiens_hsa050162.39517018
12Circadian entrainment_Homo sapiens_hsa047132.18770141
13Cardiac muscle contraction_Homo sapiens_hsa042602.03228453
14Vibrio cholerae infection_Homo sapiens_hsa051102.03192969
15Dopaminergic synapse_Homo sapiens_hsa047281.96525165
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90375556
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89628867
18Glutamatergic synapse_Homo sapiens_hsa047241.89380684
19Fatty acid biosynthesis_Homo sapiens_hsa000611.88837912
20Amphetamine addiction_Homo sapiens_hsa050311.77945409
21Cocaine addiction_Homo sapiens_hsa050301.71871969
22Taste transduction_Homo sapiens_hsa047421.58960233
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56019002
24Long-term potentiation_Homo sapiens_hsa047201.55275837
25Serotonergic synapse_Homo sapiens_hsa047261.54627617
26Insulin secretion_Homo sapiens_hsa049111.49681759
27Cholinergic synapse_Homo sapiens_hsa047251.43834010
28Renin secretion_Homo sapiens_hsa049241.34314614
29Salivary secretion_Homo sapiens_hsa049701.32655445
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22335949
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22111233
32Long-term depression_Homo sapiens_hsa047301.20184801
33Sulfur relay system_Homo sapiens_hsa041221.19634614
34Axon guidance_Homo sapiens_hsa043601.17713262
35Gastric acid secretion_Homo sapiens_hsa049711.14677201
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13969182
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12630913
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12295939
39Phototransduction_Homo sapiens_hsa047441.11462048
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08756045
41Ribosome_Homo sapiens_hsa030101.03234072
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02118248
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99986927
44Gap junction_Homo sapiens_hsa045400.96406307
45Type I diabetes mellitus_Homo sapiens_hsa049400.95946938
46Prion diseases_Homo sapiens_hsa050200.92694301
47Estrogen signaling pathway_Homo sapiens_hsa049150.91594145
48Oxytocin signaling pathway_Homo sapiens_hsa049210.89306452
49Melanogenesis_Homo sapiens_hsa049160.88849382
50GnRH signaling pathway_Homo sapiens_hsa049120.88032515
51Circadian rhythm_Homo sapiens_hsa047100.85749004
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82833105
53Glycerolipid metabolism_Homo sapiens_hsa005610.82502844
54Tyrosine metabolism_Homo sapiens_hsa003500.79456457
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79172283
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78514538
57Calcium signaling pathway_Homo sapiens_hsa040200.78185986
58Alcoholism_Homo sapiens_hsa050340.75253875
59Histidine metabolism_Homo sapiens_hsa003400.73565361
60Thyroid hormone synthesis_Homo sapiens_hsa049180.73387463
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70890200
62Dilated cardiomyopathy_Homo sapiens_hsa054140.70627212
63Phagosome_Homo sapiens_hsa041450.70598667
64Rheumatoid arthritis_Homo sapiens_hsa053230.69628801
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64969867
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.62800424
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62676385
68Regulation of autophagy_Homo sapiens_hsa041400.62052031
69cAMP signaling pathway_Homo sapiens_hsa040240.61453586
70Tryptophan metabolism_Homo sapiens_hsa003800.60011873
71Protein digestion and absorption_Homo sapiens_hsa049740.57338288
72Fat digestion and absorption_Homo sapiens_hsa049750.56961369
73Type II diabetes mellitus_Homo sapiens_hsa049300.56436555
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56267360
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54506265
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.53854115
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53182291
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50440711
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.50116639
80Glucagon signaling pathway_Homo sapiens_hsa049220.50111791
81Bile secretion_Homo sapiens_hsa049760.48538063
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.47901735
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47227846
84Butanoate metabolism_Homo sapiens_hsa006500.46563778
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46199356
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45581428
87Rap1 signaling pathway_Homo sapiens_hsa040150.44492920
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.44374434
89Protein export_Homo sapiens_hsa030600.43243749
90Pyruvate metabolism_Homo sapiens_hsa006200.43003376
91Sulfur metabolism_Homo sapiens_hsa009200.38658902
92Mineral absorption_Homo sapiens_hsa049780.37700722
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37691640
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35845694
95Oocyte meiosis_Homo sapiens_hsa041140.34771050
96Proteasome_Homo sapiens_hsa030500.34444227
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.34243799
98Ovarian steroidogenesis_Homo sapiens_hsa049130.34205756
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34053752
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33861397
101Autoimmune thyroid disease_Homo sapiens_hsa053200.33808740
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33019904
103African trypanosomiasis_Homo sapiens_hsa051430.32898375
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31399839
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31207946
106Ras signaling pathway_Homo sapiens_hsa040140.31122435
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30616652
108Fatty acid degradation_Homo sapiens_hsa000710.29438941
109Starch and sucrose metabolism_Homo sapiens_hsa005000.28858555
110Fatty acid metabolism_Homo sapiens_hsa012120.28228066
111Pancreatic secretion_Homo sapiens_hsa049720.28045397
112Galactose metabolism_Homo sapiens_hsa000520.27969433
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27105409
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27036896
115MAPK signaling pathway_Homo sapiens_hsa040100.26960729
116ErbB signaling pathway_Homo sapiens_hsa040120.26747598
117Wnt signaling pathway_Homo sapiens_hsa043100.25894758
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24719435
119Dorso-ventral axis formation_Homo sapiens_hsa043200.24617788
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24497733
121Peroxisome_Homo sapiens_hsa041460.24350430
122Glioma_Homo sapiens_hsa052140.23633623
123Arginine biosynthesis_Homo sapiens_hsa002200.22283966
124Amoebiasis_Homo sapiens_hsa051460.22263839
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21094261
126Metabolic pathways_Homo sapiens_hsa011000.21034527
127Non-small cell lung cancer_Homo sapiens_hsa052230.19811433
128Insulin signaling pathway_Homo sapiens_hsa049100.16039499
129Vitamin B6 metabolism_Homo sapiens_hsa007500.14003119
130PPAR signaling pathway_Homo sapiens_hsa033200.13576008
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13045743
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11721471

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