ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	limb bud formation (GO:0060174)	3.77945411
2	replication fork processing (GO:0031297)	3.75147688
3	DNA double-strand break processing (GO:0000729)	3.68680520
4	behavioral response to nicotine (GO:0035095)	3.62799941
5	somite development (GO:0061053)	3.42500683
6	kidney morphogenesis (GO:0060993)	3.40381568
7	dorsal/ventral axis specification (GO:0009950)	3.32849390
8	intraciliary transport (GO:0042073)	3.22935411
9	chromatin remodeling at centromere (GO:0031055)	3.19665597
10	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.09600327
11	lateral sprouting from an epithelium (GO:0060601)	3.06996933
12	nonmotile primary cilium assembly (GO:0035058)	2.92923133
13	CENP-A containing nucleosome assembly (GO:0034080)	2.90655231
14	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.81982022
15	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.81982022
16	negative regulation of axon guidance (GO:1902668)	2.80338938
17	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.79899545
18	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.79899545
19	regulation of translation, ncRNA-mediated (GO:0045974)	2.79899545
20	retinal ganglion cell axon guidance (GO:0031290)	2.79832376
21	atrial cardiac muscle cell action potential (GO:0086014)	2.79099939
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.78833392
23	histone exchange (GO:0043486)	2.78369552
24	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.76390716
25	cell proliferation in forebrain (GO:0021846)	2.75898536
26	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.75015774
27	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.74192680
28	presynaptic membrane assembly (GO:0097105)	2.73929619
29	regulation of mesoderm development (GO:2000380)	2.73441945
30	cornea development in camera-type eye (GO:0061303)	2.72206898
31	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.67063991
32	pyrimidine nucleobase catabolic process (GO:0006208)	2.66405179
33	DNA replication checkpoint (GO:0000076)	2.62552765
34	DNA strand renaturation (GO:0000733)	2.61212229
35	water-soluble vitamin biosynthetic process (GO:0042364)	2.60553064
36	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.60024964
37	olfactory bulb development (GO:0021772)	2.58357614
38	kinetochore organization (GO:0051383)	2.57452184
39	resolution of meiotic recombination intermediates (GO:0000712)	2.56524821
40	regulation of hippo signaling (GO:0035330)	2.54950025
41	epithelial cilium movement (GO:0003351)	2.54949860
42	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.53668099
43	regulation of meiosis I (GO:0060631)	2.53598827
44	regulation of posttranscriptional gene silencing (GO:0060147)	2.53540329
45	regulation of gene silencing by miRNA (GO:0060964)	2.53540329
46	regulation of gene silencing by RNA (GO:0060966)	2.53540329
47	spinal cord development (GO:0021510)	2.51938003
48	outer ear morphogenesis (GO:0042473)	2.51195748
49	negative regulation of astrocyte differentiation (GO:0048712)	2.48651750
50	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.44229708
51	pituitary gland development (GO:0021983)	2.44223259
52	lysine metabolic process (GO:0006553)	2.44082348
53	lysine catabolic process (GO:0006554)	2.44082348
54	kinetochore assembly (GO:0051382)	2.42069398
55	positive regulation of gastrulation (GO:2000543)	2.41801120
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.41413724
57	presynaptic membrane organization (GO:0097090)	2.41258790
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.39685266
59	cilium morphogenesis (GO:0060271)	2.39070099
60	serine family amino acid catabolic process (GO:0009071)	2.38233567
61	otic vesicle formation (GO:0030916)	2.36707476
62	response to pheromone (GO:0019236)	2.36517395
63	cilium organization (GO:0044782)	2.35506842
64	regulation of collateral sprouting (GO:0048670)	2.35455444
65	postreplication repair (GO:0006301)	2.35293454
66	cilium assembly (GO:0042384)	2.33974560
67	DNA replication-dependent nucleosome assembly (GO:0006335)	2.32510934
68	DNA replication-dependent nucleosome organization (GO:0034723)	2.32510934
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.32510827
70	NADH dehydrogenase complex assembly (GO:0010257)	2.32510827
71	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.32510827
72	protein complex biogenesis (GO:0070271)	2.32131628
73	meiotic chromosome segregation (GO:0045132)	2.32117869
74	DNA replication-independent nucleosome assembly (GO:0006336)	2.31824734
75	DNA replication-independent nucleosome organization (GO:0034724)	2.31824734
76	thalamus development (GO:0021794)	2.31304696
77	appendage development (GO:0048736)	2.30818171
78	limb development (GO:0060173)	2.30818171
79	head development (GO:0060322)	2.30124873
80	cellular response to cholesterol (GO:0071397)	2.29189274
81	recombinational repair (GO:0000725)	2.26849071
82	regulation of DNA endoreduplication (GO:0032875)	2.25902077
83	respiratory chain complex IV assembly (GO:0008535)	2.25760359
84	double-strand break repair via homologous recombination (GO:0000724)	2.24501705
85	regulation of mitotic spindle checkpoint (GO:1903504)	2.24482719
86	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.24482719
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.24378289
88	indolalkylamine metabolic process (GO:0006586)	2.23461058
89	translesion synthesis (GO:0019985)	2.22361083
90	hindbrain development (GO:0030902)	2.21869115
91	smoothened signaling pathway (GO:0007224)	2.20232211
92	DNA damage response, detection of DNA damage (GO:0042769)	2.19388590
93	indole-containing compound catabolic process (GO:0042436)	2.17184404
94	indolalkylamine catabolic process (GO:0046218)	2.17184404
95	tryptophan catabolic process (GO:0006569)	2.17184404
96	L-fucose catabolic process (GO:0042355)	2.17182939
97	fucose catabolic process (GO:0019317)	2.17182939
98	L-fucose metabolic process (GO:0042354)	2.17182939
99	generation of neurons (GO:0048699)	2.16083434
100	protein K6-linked ubiquitination (GO:0085020)	2.15402544

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.38078206
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.82766811
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55062006
4	VDR_22108803_ChIP-Seq_LS180_Human	2.51015835
5	EWS_26573619_Chip-Seq_HEK293_Human	2.47963049
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.44989688
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37230035
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35686040
9	FUS_26573619_Chip-Seq_HEK293_Human	2.30269349
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.29626507
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.28953866
12	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.27772565
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.17847220
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.16163068
15	P300_19829295_ChIP-Seq_ESCs_Human	2.13339629
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09789059
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06161766
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02674438
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01177587
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97270210
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95433400
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.91882307
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.91756010
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89236255
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88854947
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.87079729
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.85519230
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.85249311
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.82490763
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.80253865
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79520617
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67633235
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.63017597
34	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.47717246
35	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.46631186
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45700437
37	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.45424675
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44618255
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43985918
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42710125
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40378661
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39654469
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38235571
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37661113
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35473101
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34162792
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.33105551
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30730336
49	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29841197
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28225600
51	E2F7_22180533_ChIP-Seq_HELA_Human	1.28152637
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27840606
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23940619
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23119475
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22625634
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21989156
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21989156
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21397202
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21276077
60	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20743005
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16702986
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16682055
63	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16540898
64	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.16507282
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15875560
66	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.15588491
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14906766
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.13492953
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12719695
70	AR_25329375_ChIP-Seq_VCAP_Human	1.11284225
71	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.10736061
72	SOX9_26525672_Chip-Seq_HEART_Mouse	1.09422600
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09129425
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.09092480
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.08512996
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08512996
77	STAT3_23295773_ChIP-Seq_U87_Human	1.06226973
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05607361
79	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.02058378
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01752447
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01602065
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01602065
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00915793
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00797557
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00054273
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98620255
87	TP53_22573176_ChIP-Seq_HFKS_Human	0.98438524
88	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.98134022
89	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.96944736
90	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.96317371
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.95925769
92	TCF4_23295773_ChIP-Seq_U87_Human	0.95502286
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94321376
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93108596
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.92709777
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91974440
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91680632
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.88722957
99	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.88134029
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.87132184

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.58197342
2	MP0010030_abnormal_orbit_morphology	2.89236189
3	MP0002938_white_spotting	2.58150083
4	MP0004133_heterotaxia	2.38125989
5	MP0003890_abnormal_embryonic-extraembry	2.36680620
6	MP0001293_anophthalmia	2.27787598
7	MP0003122_maternal_imprinting	2.10270801
8	MP0008877_abnormal_DNA_methylation	2.08073185
9	MP0003136_yellow_coat_color	2.06547820
10	MP0003195_calcinosis	2.04750682
11	MP0002102_abnormal_ear_morphology	1.97555234
12	MP0003937_abnormal_limbs/digits/tail_de	1.96204443
13	MP0003121_genomic_imprinting	1.92041664
14	MP0000049_abnormal_middle_ear	1.87460370
15	MP0003119_abnormal_digestive_system	1.79282835
16	MP0000778_abnormal_nervous_system	1.76482393
17	MP0008789_abnormal_olfactory_epithelium	1.74596149
18	MP0002234_abnormal_pharynx_morphology	1.73762232
19	MP0001485_abnormal_pinna_reflex	1.72270023
20	MP0003880_abnormal_central_pattern	1.68972550
21	MP0001529_abnormal_vocalization	1.61482100
22	MP0000566_synostosis	1.56810134
23	MP0003787_abnormal_imprinting	1.55205404
24	MP0003938_abnormal_ear_development	1.54192393
25	MP0009053_abnormal_anal_canal	1.53717453
26	MP0008058_abnormal_DNA_repair	1.51210721
27	MP0000631_abnormal_neuroendocrine_gland	1.50484366
28	MP0002653_abnormal_ependyma_morphology	1.49528998
29	MP0005551_abnormal_eye_electrophysiolog	1.48409771
30	MP0002233_abnormal_nose_morphology	1.47796806
31	MP0001286_abnormal_eye_development	1.47534872
32	MP0002751_abnormal_autonomic_nervous	1.46340568
33	MP0003283_abnormal_digestive_organ	1.46308130
34	MP0005499_abnormal_olfactory_system	1.43113255
35	MP0005394_taste/olfaction_phenotype	1.43113255
36	MP0000537_abnormal_urethra_morphology	1.42343680
37	MP0003567_abnormal_fetal_cardiomyocyte	1.40299875
38	MP0006072_abnormal_retinal_apoptosis	1.38789696
39	MP0003755_abnormal_palate_morphology	1.34258494
40	MP0002837_dystrophic_cardiac_calcinosis	1.31163487
41	MP0005248_abnormal_Harderian_gland	1.30528553
42	MP0002736_abnormal_nociception_after	1.26758996
43	MP0010094_abnormal_chromosome_stability	1.25876249
44	MP0000516_abnormal_urinary_system	1.24615663
45	MP0005367_renal/urinary_system_phenotyp	1.24615663
46	MP0003942_abnormal_urinary_system	1.24381489
47	MP0001984_abnormal_olfaction	1.23926530
48	MP0002282_abnormal_trachea_morphology	1.23785370
49	MP0000569_abnormal_digit_pigmentation	1.23148195
50	MP0002697_abnormal_eye_size	1.21930628
51	MP0003718_maternal_effect	1.21033351
52	MP0002638_abnormal_pupillary_reflex	1.18206589
53	MP0005253_abnormal_eye_physiology	1.16354118
54	MP0006054_spinal_hemorrhage	1.15704916
55	MP0002111_abnormal_tail_morphology	1.15448255
56	MP0004885_abnormal_endolymph	1.12035013
57	MP0003861_abnormal_nervous_system	1.11845526
58	MP0003693_abnormal_embryo_hatching	1.11293095
59	MP0001968_abnormal_touch/_nociception	1.09132859
60	MP0005391_vision/eye_phenotype	1.07158254
61	MP0008932_abnormal_embryonic_tissue	1.06256530
62	MP0005195_abnormal_posterior_eye	1.05851095
63	MP0000428_abnormal_craniofacial_morphol	1.03021645
64	MP0003137_abnormal_impulse_conducting	1.02460066
65	MP0002254_reproductive_system_inflammat	0.99455595
66	MP0006276_abnormal_autonomic_nervous	0.99434839
67	MP0002752_abnormal_somatic_nervous	0.98788502
68	MP0001486_abnormal_startle_reflex	0.98310724
69	MP0002184_abnormal_innervation	0.98224116
70	MP0003385_abnormal_body_wall	0.97538422
71	MP0000026_abnormal_inner_ear	0.95520140
72	MP0001177_atelectasis	0.95416928
73	MP0000647_abnormal_sebaceous_gland	0.94856824
74	MP0005084_abnormal_gallbladder_morpholo	0.93627634
75	MP0009250_abnormal_appendicular_skeleto	0.92312006
76	MP0005187_abnormal_penis_morphology	0.91993782
77	MP0002116_abnormal_craniofacial_bone	0.91439161
78	MP0003935_abnormal_craniofacial_develop	0.91232353
79	MP0000534_abnormal_ureter_morphology	0.87723820
80	MP0004957_abnormal_blastocyst_morpholog	0.87620415
81	MP0003941_abnormal_skin_development	0.87025265
82	MP0002249_abnormal_larynx_morphology	0.86988712
83	MP0002084_abnormal_developmental_patter	0.85819649
84	MP0009697_abnormal_copulation	0.85698188
85	MP0002092_abnormal_eye_morphology	0.84746040
86	MP0004215_abnormal_myocardial_fiber	0.84251774
87	MP0003011_delayed_dark_adaptation	0.83812878
88	MP0002932_abnormal_joint_morphology	0.83367608
89	MP0002152_abnormal_brain_morphology	0.83123942
90	MP0002085_abnormal_embryonic_tissue	0.82768369
91	MP0002160_abnormal_reproductive_system	0.82566130
92	MP0002557_abnormal_social/conspecific_i	0.82229457
93	MP0000955_abnormal_spinal_cord	0.81266764
94	MP0002734_abnormal_mechanical_nocicepti	0.80380035
95	MP0009745_abnormal_behavioral_response	0.79848412
96	MP0000427_abnormal_hair_cycle	0.79545136
97	MP0005646_abnormal_pituitary_gland	0.78874836
98	MP0009703_decreased_birth_body	0.78062705
99	MP0001299_abnormal_eye_distance/	0.77220787
100	MP0009046_muscle_twitch	0.77047861

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.50754168
2	Septo-optic dysplasia (HP:0100842)	3.50445833
3	Pancreatic cysts (HP:0001737)	3.39069460
4	True hermaphroditism (HP:0010459)	3.29501900
5	Abnormality of midbrain morphology (HP:0002418)	3.24049153
6	Molar tooth sign on MRI (HP:0002419)	3.24049153
7	Nephronophthisis (HP:0000090)	3.10742840
8	Colon cancer (HP:0003003)	3.08708961
9	Abnormality of the labia minora (HP:0012880)	2.98916018
10	Anophthalmia (HP:0000528)	2.68810860
11	Intestinal atresia (HP:0011100)	2.60891631
12	Abnormality of the renal medulla (HP:0100957)	2.60423279
13	Chronic hepatic failure (HP:0100626)	2.59072116
14	Anencephaly (HP:0002323)	2.43400340
15	Optic nerve hypoplasia (HP:0000609)	2.42055570
16	Type II lissencephaly (HP:0007260)	2.38301877
17	Abnormal lung lobation (HP:0002101)	2.38267903
18	Cystic liver disease (HP:0006706)	2.36502851
19	Pendular nystagmus (HP:0012043)	2.33855510
20	Sclerocornea (HP:0000647)	2.33823684
21	Medial flaring of the eyebrow (HP:0010747)	2.33765827
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31329862
23	Genital tract atresia (HP:0001827)	2.29811938
24	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.28708100
25	Vaginal atresia (HP:0000148)	2.28558338
26	Renal hypoplasia (HP:0000089)	2.24379022
27	Hypoplastic pelvis (HP:0008839)	2.23539091
28	Volvulus (HP:0002580)	2.22223830
29	Meckel diverticulum (HP:0002245)	2.21954437
30	Bilateral microphthalmos (HP:0007633)	2.19504300
31	Abnormality of the ileum (HP:0001549)	2.18192779
32	Absent septum pellucidum (HP:0001331)	2.18178555
33	Ectopic kidney (HP:0000086)	2.16911311
34	Hypoplasia of the pons (HP:0012110)	2.16336532
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.16214873
36	Abolished electroretinogram (ERG) (HP:0000550)	2.14706023
37	Cerebellar dysplasia (HP:0007033)	2.10835471
38	Preaxial hand polydactyly (HP:0001177)	2.10183936
39	Dandy-Walker malformation (HP:0001305)	2.07832751
40	Ependymoma (HP:0002888)	2.05793831
41	Hyperglycinemia (HP:0002154)	2.04204860
42	Abnormality of the pons (HP:0007361)	2.02327260
43	Postaxial foot polydactyly (HP:0001830)	2.01314817
44	Postaxial hand polydactyly (HP:0001162)	1.98870150
45	Gastrointestinal atresia (HP:0002589)	1.96065904
46	Bifid tongue (HP:0010297)	1.94369529
47	Supernumerary spleens (HP:0009799)	1.94222970
48	Patellar aplasia (HP:0006443)	1.93035382
49	Congenital primary aphakia (HP:0007707)	1.91456146
50	Gait imbalance (HP:0002141)	1.91107460
51	Hyperglycinuria (HP:0003108)	1.90741336
52	Male pseudohermaphroditism (HP:0000037)	1.90721917
53	Aqueductal stenosis (HP:0002410)	1.84369176
54	Abnormality of the septum pellucidum (HP:0007375)	1.84131745
55	Occipital encephalocele (HP:0002085)	1.83828905
56	Aplasia/Hypoplasia of the patella (HP:0006498)	1.83573769
57	Small hand (HP:0200055)	1.83382503
58	Triphalangeal thumb (HP:0001199)	1.82685886
59	Tubular atrophy (HP:0000092)	1.82404305
60	Abnormality of the renal cortex (HP:0011035)	1.81129801
61	Rib fusion (HP:0000902)	1.80545474
62	Preaxial foot polydactyly (HP:0001841)	1.78912093
63	Hemivertebrae (HP:0002937)	1.78545007
64	Congenital hepatic fibrosis (HP:0002612)	1.78504753
65	Chorioretinal atrophy (HP:0000533)	1.77566124
66	Holoprosencephaly (HP:0001360)	1.76234947
67	Narrow forehead (HP:0000341)	1.75538451
68	Maternal diabetes (HP:0009800)	1.74273618
69	Esophageal atresia (HP:0002032)	1.74069236
70	Cutaneous finger syndactyly (HP:0010554)	1.74064247
71	Methylmalonic acidemia (HP:0002912)	1.73946772
72	Tubulointerstitial nephritis (HP:0001970)	1.73935020
73	Glioma (HP:0009733)	1.73287977
74	Nephrogenic diabetes insipidus (HP:0009806)	1.72504379
75	Abnormality of glycine metabolism (HP:0010895)	1.71153823
76	Abnormality of serine family amino acid metabolism (HP:0010894)	1.71153823
77	Sloping forehead (HP:0000340)	1.70451308
78	Lissencephaly (HP:0001339)	1.69813664
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.69518545
80	Abnormality of chromosome stability (HP:0003220)	1.69052272
81	Abnormality of the duodenum (HP:0002246)	1.67046574
82	Abnormal biliary tract physiology (HP:0012439)	1.65604178
83	Bile duct proliferation (HP:0001408)	1.65604178
84	Rectal fistula (HP:0100590)	1.63987107
85	Rectovaginal fistula (HP:0000143)	1.63987107
86	Increased corneal curvature (HP:0100692)	1.63627319
87	Keratoconus (HP:0000563)	1.63627319
88	Multicystic kidney dysplasia (HP:0000003)	1.63181944
89	Astrocytoma (HP:0009592)	1.61983574
90	Abnormality of the astrocytes (HP:0100707)	1.61983574
91	Chorioretinal coloboma (HP:0000567)	1.61788706
92	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.60984314
93	Acute necrotizing encephalopathy (HP:0006965)	1.60615422
94	Labial hypoplasia (HP:0000066)	1.60336400
95	Absent thumb (HP:0009777)	1.60323486
96	Oligodactyly (hands) (HP:0001180)	1.60255136
97	Asplenia (HP:0001746)	1.58326817
98	Absent radius (HP:0003974)	1.58294364
99	Hypoplastic female external genitalia (HP:0012815)	1.58261717
100	Micropenis (HP:0000054)	1.55965772

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.40187930
2	MKNK2	2.92022740
3	WNK3	2.88850707
4	TRIM28	2.84814224
5	FRK	2.77511003
6	BMPR1B	2.67826698
7	NUAK1	2.38688009
8	EPHA4	2.30825224
9	ZAK	2.19018822
10	MKNK1	2.16346807
11	VRK2	2.15665742
12	BUB1	2.14450825
13	PLK3	1.88942801
14	ACVR1B	1.83807622
15	PNCK	1.83306646
16	WNK4	1.71692348
17	CDC7	1.70127606
18	WEE1	1.66240199
19	CASK	1.66062057
20	BRSK2	1.65892713
21	ADRBK2	1.65621217
22	MAPK13	1.63409856
23	MAP3K4	1.58607305
24	VRK1	1.57024038
25	PLK4	1.56688018
26	MAP4K2	1.53723244
27	SRPK1	1.52752260
28	STK39	1.51747926
29	INSRR	1.50929084
30	GRK1	1.46742770
31	BCR	1.45165243
32	TAF1	1.40857287
33	DYRK2	1.40844030
34	ERBB3	1.39712252
35	PLK2	1.36587155
36	FGFR2	1.27710918
37	EPHB2	1.27026805
38	CSNK1G1	1.21955778
39	STK16	1.21213183
40	PLK1	1.15664671
41	TIE1	1.08772034
42	PINK1	1.06015234
43	TTK	1.05490330
44	TGFBR1	1.02534461
45	STK38L	0.98494103
46	CSNK1G2	0.97895261
47	OXSR1	0.97475359
48	TLK1	0.96934691
49	PBK	0.95824861
50	CSNK1G3	0.94418135
51	MARK1	0.85938357
52	PAK3	0.85581973
53	PRKD3	0.85190511
54	NEK1	0.84970167
55	PIK3CA	0.84739670
56	PRKCG	0.84565093
57	MAP2K7	0.83644359
58	CSNK1A1L	0.81363347
59	TSSK6	0.79913020
60	BRSK1	0.77738142
61	NEK2	0.75381755
62	STK3	0.75099774
63	CHEK2	0.73797681
64	FGFR1	0.72599219
65	ATR	0.69159816
66	FLT3	0.68354194
67	PRKCE	0.68103343
68	NLK	0.67063315
69	LATS1	0.64750971
70	BCKDK	0.64079603
71	PKN1	0.63742651
72	MINK1	0.63220914
73	NTRK2	0.63056989
74	EIF2AK3	0.62340214
75	NME1	0.60743539
76	ATM	0.57006550
77	ADRBK1	0.55515895
78	ERBB4	0.52138755
79	MUSK	0.50365427
80	EIF2AK1	0.47407235
81	DYRK3	0.45988944
82	AURKB	0.44628569
83	CAMK1G	0.43578724
84	PASK	0.43114796
85	CSNK1A1	0.40611344
86	ERBB2	0.39712446
87	STK11	0.39655168
88	CSNK1E	0.38760238
89	CSNK1D	0.35300169
90	EIF2AK2	0.35001206
91	DAPK2	0.33742190
92	CDK3	0.32703137
93	BRD4	0.32575419
94	CAMK2A	0.32346591
95	PRKDC	0.31969433
96	ROCK1	0.31428825
97	CHEK1	0.31186707
98	CDK1	0.30585817
99	CSNK2A1	0.29695990
100	PRKACA	0.27568520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47823369
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23460052
3	Protein export_Homo sapiens_hsa03060	2.19637795
4	Homologous recombination_Homo sapiens_hsa03440	2.16202372
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.15082838
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.13273231
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.04074600
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.96357418
9	Basal cell carcinoma_Homo sapiens_hsa05217	1.93803278
10	Phototransduction_Homo sapiens_hsa04744	1.92237430
11	Steroid biosynthesis_Homo sapiens_hsa00100	1.87218982
12	Basal transcription factors_Homo sapiens_hsa03022	1.84218628
13	Butanoate metabolism_Homo sapiens_hsa00650	1.78604443
14	RNA polymerase_Homo sapiens_hsa03020	1.74921066
15	Mismatch repair_Homo sapiens_hsa03430	1.72434389
16	Propanoate metabolism_Homo sapiens_hsa00640	1.70455006
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.67948226
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59016772
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58910702
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.53976567
21	DNA replication_Homo sapiens_hsa03030	1.52529695
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.52037500
23	Nicotine addiction_Homo sapiens_hsa05033	1.49685476
24	RNA degradation_Homo sapiens_hsa03018	1.48397242
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.48307882
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.43311460
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38683414
28	Proteasome_Homo sapiens_hsa03050	1.36707693
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.33413102
30	Base excision repair_Homo sapiens_hsa03410	1.32397657
31	One carbon pool by folate_Homo sapiens_hsa00670	1.32239006
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.30543360
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30048474
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29893617
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28196445
36	Parkinsons disease_Homo sapiens_hsa05012	1.25985202
37	Hippo signaling pathway_Homo sapiens_hsa04390	1.24778903
38	RNA transport_Homo sapiens_hsa03013	1.23931068
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.16951834
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.14527778
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12760413
42	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.12653142
43	Retinol metabolism_Homo sapiens_hsa00830	1.10871455
44	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.09511767
45	Spliceosome_Homo sapiens_hsa03040	1.07248414
46	Cell cycle_Homo sapiens_hsa04110	1.06961129
47	Wnt signaling pathway_Homo sapiens_hsa04310	1.06266612
48	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.04581467
49	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03193768
50	Pyruvate metabolism_Homo sapiens_hsa00620	1.03135650
51	Huntingtons disease_Homo sapiens_hsa05016	1.02525106
52	Ribosome_Homo sapiens_hsa03010	1.00827359
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96552281
54	Caffeine metabolism_Homo sapiens_hsa00232	0.95919339
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95139790
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93950367
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.93648120
58	Peroxisome_Homo sapiens_hsa04146	0.92130887
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90437812
60	Fatty acid elongation_Homo sapiens_hsa00062	0.89857237
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88729600
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88701385
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86601332
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86464437
65	Lysine degradation_Homo sapiens_hsa00310	0.86209642
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85632112
67	Fatty acid degradation_Homo sapiens_hsa00071	0.83093121
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.82889697
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81623894
70	Purine metabolism_Homo sapiens_hsa00230	0.80505071
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79531107
72	p53 signaling pathway_Homo sapiens_hsa04115	0.78117295
73	Taste transduction_Homo sapiens_hsa04742	0.77006360
74	Sulfur metabolism_Homo sapiens_hsa00920	0.75747032
75	Histidine metabolism_Homo sapiens_hsa00340	0.75591063
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74708034
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71505362
78	Alzheimers disease_Homo sapiens_hsa05010	0.69911087
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69904723
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.69607988
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69402977
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69184235
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.67942114
84	Axon guidance_Homo sapiens_hsa04360	0.67449340
85	Metabolic pathways_Homo sapiens_hsa01100	0.66484896
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.64525249
87	mRNA surveillance pathway_Homo sapiens_hsa03015	0.63938751
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60546341
89	Oocyte meiosis_Homo sapiens_hsa04114	0.59302472
90	Sulfur relay system_Homo sapiens_hsa04122	0.53737270
91	Morphine addiction_Homo sapiens_hsa05032	0.52407991
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50816058
93	GABAergic synapse_Homo sapiens_hsa04727	0.50734572
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49377394
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49264532
96	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.47696506
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47293559
98	Folate biosynthesis_Homo sapiens_hsa00790	0.47010241
99	Olfactory transduction_Homo sapiens_hsa04740	0.45722179
100	Serotonergic synapse_Homo sapiens_hsa04726	0.45195805

CASC10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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