CASC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.80387960
2histone H3-K36 demethylation (GO:0070544)3.90119341
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.82885357
4histone lysine demethylation (GO:0070076)3.79960104
5nuclear pore complex assembly (GO:0051292)3.65423734
6histone demethylation (GO:0016577)3.59806531
7regulation of RNA export from nucleus (GO:0046831)3.57729735
8negative regulation of histone methylation (GO:0031061)3.52708053
9epithelial cell fate commitment (GO:0072148)3.46887366
10negative regulation of mRNA processing (GO:0050686)3.33694864
11nuclear pore organization (GO:0006999)3.32609712
12protein dealkylation (GO:0008214)3.31971396
13protein demethylation (GO:0006482)3.31971396
14regulation of NFAT protein import into nucleus (GO:0051532)3.30841423
15negative regulation of RNA splicing (GO:0033119)3.29812983
16histone H4-K12 acetylation (GO:0043983)3.29097950
17glucocorticoid receptor signaling pathway (GO:0042921)3.24091627
18regulation of ARF protein signal transduction (GO:0032012)3.23948834
19positive regulation of histone deacetylation (GO:0031065)3.20560433
20cytoplasmic mRNA processing body assembly (GO:0033962)3.18605263
21intracellular estrogen receptor signaling pathway (GO:0030520)3.15794908
22negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14893010
23cellular response to epidermal growth factor stimulus (GO:0071364)3.14673289
24dosage compensation (GO:0007549)3.14096777
25negative regulation of mRNA metabolic process (GO:1903312)3.13680301
26peptidyl-arginine omega-N-methylation (GO:0035247)3.12499303
27negative regulation of cell killing (GO:0031342)3.12490259
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12490259
29response to epidermal growth factor (GO:0070849)3.09196253
30peptidyl-arginine methylation (GO:0018216)3.08971802
31peptidyl-arginine N-methylation (GO:0035246)3.08971802
32stress granule assembly (GO:0034063)3.08103643
33positive regulation of RNA splicing (GO:0033120)3.07600214
34protein-DNA complex disassembly (GO:0032986)3.04369659
35nucleosome disassembly (GO:0006337)3.04369659
36regulation of chromatin binding (GO:0035561)3.01693530
37negative regulation of gene expression, epigenetic (GO:0045814)2.99838891
38cytoskeletal anchoring at plasma membrane (GO:0007016)2.99749036
39negative regulation of erythrocyte differentiation (GO:0045647)2.97134620
40regulation of nucleobase-containing compound transport (GO:0032239)2.96968932
41heterochromatin organization (GO:0070828)2.95710983
42mRNA splice site selection (GO:0006376)2.94456183
43ventricular trabecula myocardium morphogenesis (GO:0003222)2.94394498
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.93931281
45mRNA stabilization (GO:0048255)2.93024642
46RNA stabilization (GO:0043489)2.93024642
47positive regulation of gene expression, epigenetic (GO:0045815)2.87850003
48spliceosomal tri-snRNP complex assembly (GO:0000244)2.86391334
49histone H4-K16 acetylation (GO:0043984)2.85253080
50regulation of G0 to G1 transition (GO:0070316)2.84959197
51erythrocyte development (GO:0048821)2.84112676
52histone H4 deacetylation (GO:0070933)2.83882679
53mitotic sister chromatid cohesion (GO:0007064)2.83777465
54megakaryocyte development (GO:0035855)2.81901593
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81249211
56regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80476209
57histone H3-K4 trimethylation (GO:0080182)2.80317944
58alternative mRNA splicing, via spliceosome (GO:0000380)2.79203131
59chromatin silencing (GO:0006342)2.76123866
60histone H4-K8 acetylation (GO:0043982)2.75102444
61histone H4-K5 acetylation (GO:0043981)2.75102444
62layer formation in cerebral cortex (GO:0021819)2.73766876
63negative regulation of glial cell proliferation (GO:0060253)2.72075716
64trabecula morphogenesis (GO:0061383)2.72022177
65positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.71350704
66histone H3-K4 methylation (GO:0051568)2.71124809
67corticosteroid receptor signaling pathway (GO:0031958)2.70306227
68regulation of histone H3-K4 methylation (GO:0051569)2.69416850
69peptidyl-threonine phosphorylation (GO:0018107)2.68471573
70regulation of translational fidelity (GO:0006450)2.68001706
71establishment of nucleus localization (GO:0040023)2.66472296
72gene silencing (GO:0016458)2.66173837
73regulation of histone H3-K27 methylation (GO:0061085)2.65196692
74histone H3-K9 demethylation (GO:0033169)2.62935930
75cell migration in hindbrain (GO:0021535)2.60441746
76establishment of mitochondrion localization (GO:0051654)2.60040078
77apoptotic process involved in morphogenesis (GO:0060561)2.59759620
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.58001583
79peptidyl-lysine dimethylation (GO:0018027)2.57424268
80protein export from nucleus (GO:0006611)2.55025611
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54790509
82histone H4 acetylation (GO:0043967)2.54592121
83paraxial mesoderm development (GO:0048339)2.53780780
84regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.53737610
85camera-type eye morphogenesis (GO:0048593)2.53274390
86peptidyl-threonine modification (GO:0018210)2.52968154
87positive regulation of synapse maturation (GO:0090129)2.52353506
88regulation of transcription from RNA polymerase I promoter (GO:0006356)2.52261847
89regulation of synaptic vesicle exocytosis (GO:2000300)2.52250408
90NLS-bearing protein import into nucleus (GO:0006607)2.52093654
91lens fiber cell development (GO:0070307)2.52025681
92epithelial cell differentiation involved in prostate gland development (GO:0060742)2.50951114
93cerebellar granule cell differentiation (GO:0021707)2.50148935
94histone H3 deacetylation (GO:0070932)2.49904928
95positive thymic T cell selection (GO:0045059)2.49577545
96histone H2A monoubiquitination (GO:0035518)2.49164908
97determination of adult lifespan (GO:0008340)2.48611647
98pore complex assembly (GO:0046931)2.47787305
99regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.46248273
100SMAD protein complex assembly (GO:0007183)2.46096820
101gene silencing by RNA (GO:0031047)2.45784487
102regulation of female receptivity (GO:0045924)2.45611709
103negative regulation of cell size (GO:0045792)2.45554974
104regulation of ARF GTPase activity (GO:0032312)2.44926752
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43874186
106histone H3-K9 modification (GO:0061647)2.43316391
107sodium ion export (GO:0071436)2.42857879
108positive regulation of protein import into nucleus, translocation (GO:0033160)2.40482237
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40299016
110negative regulation of microtubule polymerization (GO:0031115)2.39309601
111positive regulation of protein deacetylation (GO:0090312)2.38213782
112positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37944023
113negative regulation of neurotransmitter secretion (GO:0046929)2.37911829
114heart trabecula morphogenesis (GO:0061384)2.36722130
115mRNA transcription from RNA polymerase II promoter (GO:0042789)2.36319753
116negative regulation of Ras protein signal transduction (GO:0046580)2.35651914
117regulation of mRNA stability (GO:0043488)2.35593464
118mitochondrion transport along microtubule (GO:0047497)2.34945839
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34945839
120neuronal stem cell maintenance (GO:0097150)2.34696890
121DNA unwinding involved in DNA replication (GO:0006268)2.34218008
122negative regulation of histone modification (GO:0031057)2.33948328
123embryonic foregut morphogenesis (GO:0048617)2.33605290
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33495070
1253-UTR-mediated mRNA stabilization (GO:0070935)2.32621787
126regulation of posttranscriptional gene silencing (GO:0060147)2.31578161
127regulation of gene silencing by miRNA (GO:0060964)2.31578161
128regulation of gene silencing by RNA (GO:0060966)2.31578161
129histone acetylation (GO:0016573)2.30798819
130regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.30689959
131cellular response to monoamine stimulus (GO:0071868)2.30578140
132cellular response to catecholamine stimulus (GO:0071870)2.30578140
133internal peptidyl-lysine acetylation (GO:0018393)2.30319172
134regulation of histone H3-K9 methylation (GO:0051570)2.29617628
135localization within membrane (GO:0051668)2.29451936
136cell-cell junction maintenance (GO:0045217)2.28405231
137cellular hyperosmotic response (GO:0071474)2.27482662
138histone methylation (GO:0016571)2.27234284
139trophectodermal cell differentiation (GO:0001829)2.27129959
140cardiac left ventricle morphogenesis (GO:0003214)2.27012656
141histone deacetylation (GO:0016575)2.26951709
142locomotory exploration behavior (GO:0035641)2.26927895
143regulation of sister chromatid cohesion (GO:0007063)2.26620356
144cortical actin cytoskeleton organization (GO:0030866)2.26110046
145germ cell migration (GO:0008354)2.25847547
146myelination in peripheral nervous system (GO:0022011)2.25477919
147peripheral nervous system axon ensheathment (GO:0032292)2.25477919
148coronary vasculature morphogenesis (GO:0060977)2.24631744
149negative regulation of small GTPase mediated signal transduction (GO:0051058)2.24033965
150peptidyl-lysine trimethylation (GO:0018023)2.23783436
151regulation of histone methylation (GO:0031060)2.23726643
152histone lysine methylation (GO:0034968)2.23526609
153regulation of RNA stability (GO:0043487)2.22713384
154glial cell proliferation (GO:0014009)2.21350652
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.20628781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.16032268
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.97134068
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.92327085
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35890008
5KDM2B_26808549_Chip-Seq_DND41_Human2.96460010
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.80743959
7E2F7_22180533_ChIP-Seq_HELA_Human2.78588464
8TCF7_22412390_ChIP-Seq_EML_Mouse2.73699354
9VDR_21846776_ChIP-Seq_THP-1_Human2.67278320
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62507740
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.61999547
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59866443
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.58381808
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.49875646
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.36601950
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34552588
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34041851
18KDM2B_26808549_Chip-Seq_JURKAT_Human2.20098847
19KDM2B_26808549_Chip-Seq_K562_Human2.06337977
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05607445
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05572679
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04118327
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01342121
24CLOCK_20551151_ChIP-Seq_293T_Human1.98150707
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95623825
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.94648115
27DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.93565654
28CIITA_25753668_ChIP-Seq_RAJI_Human1.93528507
29* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.89607221
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81797511
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76501577
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74253654
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71706162
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71559288
35* UTX_26944678_Chip-Seq_JUKART_Human1.71486191
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70400559
37LXR_22292898_ChIP-Seq_THP-1_Human1.69102498
38MAF_26560356_Chip-Seq_TH1_Human1.64022144
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59587043
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51259615
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.50261133
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50204265
43CREB1_26743006_Chip-Seq_LNCaP_Human1.50105923
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49572181
45ZNF263_19887448_ChIP-Seq_K562_Human1.48675990
46EZH2_22144423_ChIP-Seq_EOC_Human1.45714089
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42916483
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41862320
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40747488
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40611409
51DROSHA_22980978_ChIP-Seq_HELA_Human1.38463254
52* RARB_27405468_Chip-Seq_BRAIN_Mouse1.38183931
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37024356
54VDR_24763502_ChIP-Seq_THP-1_Human1.35057140
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34068702
56SCL_19346495_ChIP-Seq_HPC-7_Human1.33678749
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32788577
58RACK7_27058665_Chip-Seq_MCF-7_Human1.32749547
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32526594
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.31048627
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27843623
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27331690
63* NCOR1_26117541_ChIP-Seq_K562_Human1.24660992
64FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24537994
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22087281
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21853442
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18889948
68MAF_26560356_Chip-Seq_TH2_Human1.18288345
69* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18210900
70CHD1_26751641_Chip-Seq_LNCaP_Human1.17959055
71TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17328541
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17053018
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17022778
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15801667
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.15092014
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13685575
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12891444
78P68_20966046_ChIP-Seq_HELA_Human1.12882115
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12856453
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12810037
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12543015
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11818247
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11714360
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.11166999
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11122550
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10970151
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10836006
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.08828276
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08710188
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.08454428
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07859187
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07689551
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04989089
94KDM5A_27292631_Chip-Seq_BREAST_Human1.04721546
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04295503
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.04211731
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04187840
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02554730
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02252809
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01924601
101* MYB_26560356_Chip-Seq_TH1_Human1.01412231
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00516832
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.00407170
104TP53_22127205_ChIP-Seq_IMR90_Human1.00211339
105ATF3_27146783_Chip-Seq_COLON_Human0.99171064
106XRN2_22483619_ChIP-Seq_HELA_Human0.98272356
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.97634098
108* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97249507
109SPI1_23127762_ChIP-Seq_K562_Human0.97247414
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.97133572
111SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96436723
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96149125
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94943457
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.94675455
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93803023
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93273687
117SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.93066027
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.92492289
119SMC4_20622854_ChIP-Seq_HELA_Human0.92147680
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92019618
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.91799542
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.91451041
123MYB_26560356_Chip-Seq_TH2_Human0.91213225
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90706228
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90627123
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90627123
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90627123
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90427389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.18807771
2MP0005423_abnormal_somatic_nervous2.79045292
3MP0009278_abnormal_bone_marrow2.73373948
4MP0008961_abnormal_basal_metabolism2.70236169
5MP0002009_preneoplasia2.57405787
6MP0004264_abnormal_extraembryonic_tissu2.54265288
7MP0009780_abnormal_chondrocyte_physiolo2.45174439
8MP0010352_gastrointestinal_tract_polyps2.39952720
9MP0003303_peritoneal_inflammation2.30623114
10MP0010030_abnormal_orbit_morphology2.23412250
11MP0003122_maternal_imprinting2.07242683
12MP0003705_abnormal_hypodermis_morpholog1.90197845
13MP0002089_abnormal_postnatal_growth/wei1.85298696
14MP0000569_abnormal_digit_pigmentation1.84963067
15MP0000537_abnormal_urethra_morphology1.82522058
16MP0008260_abnormal_autophagy1.82459608
17MP0003121_genomic_imprinting1.76530289
18MP0001730_embryonic_growth_arrest1.74563741
19MP0003111_abnormal_nucleus_morphology1.73201070
20MP0002249_abnormal_larynx_morphology1.71096351
21MP0002653_abnormal_ependyma_morphology1.70615649
22MP0002084_abnormal_developmental_patter1.68999953
23MP0003690_abnormal_glial_cell1.67488320
24MP0003300_gastrointestinal_ulcer1.67420885
25MP0004859_abnormal_synaptic_plasticity1.65165448
26MP0004197_abnormal_fetal_growth/weight/1.62963205
27MP0003890_abnormal_embryonic-extraembry1.59076563
28MP0000350_abnormal_cell_proliferation1.58213231
29MP0004808_abnormal_hematopoietic_stem1.54063845
30MP0003123_paternal_imprinting1.53952716
31MP0003787_abnormal_imprinting1.52319620
32MP0004270_analgesia1.52142503
33MP0005409_darkened_coat_color1.51860126
34MP0005451_abnormal_body_composition1.51315967
35MP0003938_abnormal_ear_development1.49826550
36MP0002396_abnormal_hematopoietic_system1.48231967
37MP0003077_abnormal_cell_cycle1.47612961
38MP0000678_abnormal_parathyroid_gland1.46469383
39MP0000428_abnormal_craniofacial_morphol1.46029316
40MP0002085_abnormal_embryonic_tissue1.43310299
41MP0002088_abnormal_embryonic_growth/wei1.43016716
42MP0005187_abnormal_penis_morphology1.42353253
43MP0008057_abnormal_DNA_replication1.42211804
44MP0003984_embryonic_growth_retardation1.41786402
45MP0001697_abnormal_embryo_size1.41708205
46MP0005380_embryogenesis_phenotype1.40967665
47MP0001672_abnormal_embryogenesis/_devel1.40967665
48MP0002063_abnormal_learning/memory/cond1.40313015
49MP0001502_abnormal_circadian_rhythm1.38508853
50MP0002086_abnormal_extraembryonic_tissu1.37117600
51MP0003880_abnormal_central_pattern1.33043277
52MP0004233_abnormal_muscle_weight1.32304434
53MP0003861_abnormal_nervous_system1.31918530
54MP0004885_abnormal_endolymph1.31859135
55MP0003119_abnormal_digestive_system1.31644322
56MP0000733_abnormal_muscle_development1.31378692
57MP0003115_abnormal_respiratory_system1.29319970
58MP0002234_abnormal_pharynx_morphology1.24744956
59MP0004957_abnormal_blastocyst_morpholog1.24382963
60MP0004858_abnormal_nervous_system1.23920138
61MP0010234_abnormal_vibrissa_follicle1.23743286
62MP0001915_intracranial_hemorrhage1.22740179
63MP0003283_abnormal_digestive_organ1.21809572
64MP0001177_atelectasis1.21556026
65MP0001849_ear_inflammation1.20968388
66MP0009703_decreased_birth_body1.19493140
67MP0002080_prenatal_lethality1.18163472
68MP0000703_abnormal_thymus_morphology1.17259478
69MP0003221_abnormal_cardiomyocyte_apopto1.16510921
70MP0005666_abnormal_adipose_tissue1.13469687
71MP0009672_abnormal_birth_weight1.13190596
72MP0002925_abnormal_cardiovascular_devel1.11098803
73MP0003943_abnormal_hepatobiliary_system1.10710910
74MP0008877_abnormal_DNA_methylation1.08633751
75MP0004185_abnormal_adipocyte_glucose1.07955933
76MP0000778_abnormal_nervous_system1.07698368
77MP0008770_decreased_survivor_rate1.07520002
78MP0003567_abnormal_fetal_cardiomyocyte1.06581844
79MP0000465_gastrointestinal_hemorrhage1.05029343
80MP0005397_hematopoietic_system_phenotyp1.04860807
81MP0001545_abnormal_hematopoietic_system1.04860807
82MP0004782_abnormal_surfactant_physiolog1.04340551
83MP0000003_abnormal_adipose_tissue1.04024387
84MP0002909_abnormal_adrenal_gland1.03668319
85MP0003183_abnormal_peptide_metabolism1.02760573
86MP0005621_abnormal_cell_physiology1.02628398
87MP0010094_abnormal_chromosome_stability1.01088045
88MP0001270_distended_abdomen1.00992695
89MP0003878_abnormal_ear_physiology1.00733655
90MP0005377_hearing/vestibular/ear_phenot1.00733655
91MP0001346_abnormal_lacrimal_gland0.98421738
92MP0008569_lethality_at_weaning0.98227949
93MP0005623_abnormal_meninges_morphology0.97646203
94MP0003935_abnormal_craniofacial_develop0.96920722
95MP0003634_abnormal_glial_cell0.96361040
96MP0003942_abnormal_urinary_system0.95786743
97MP0002152_abnormal_brain_morphology0.95140970
98MP0001293_anophthalmia0.92697371
99MP0003635_abnormal_synaptic_transmissio0.91639924
100MP0000955_abnormal_spinal_cord0.91180898
101MP0001943_abnormal_respiration0.90499559
102MP0001784_abnormal_fluid_regulation0.89899691
103MP0004811_abnormal_neuron_physiology0.89566576
104MP0002092_abnormal_eye_morphology0.89484119
105MP0003763_abnormal_thymus_physiology0.88901279
106MP0003566_abnormal_cell_adhesion0.88391644
107MP0002116_abnormal_craniofacial_bone0.88152240
108MP0000566_synostosis0.87906534
109MP0003632_abnormal_nervous_system0.87378446
110MP0002081_perinatal_lethality0.86275851
111MP0003385_abnormal_body_wall0.86094353
112MP0009053_abnormal_anal_canal0.85759831
113MP0002398_abnormal_bone_marrow0.83290598
114MP0010630_abnormal_cardiac_muscle0.81977704
115MP0003329_amyloid_beta_deposits0.81467381
116MP0000920_abnormal_myelination0.81277767
117MP0002697_abnormal_eye_size0.81089288
118MP0003948_abnormal_gas_homeostasis0.80684512
119MP0001299_abnormal_eye_distance/0.79947043
120MP0005384_cellular_phenotype0.79612365
121MP0005248_abnormal_Harderian_gland0.78301475
122MP0003091_abnormal_cell_migration0.76895545
123MP0006072_abnormal_retinal_apoptosis0.76788180
124MP0000377_abnormal_hair_follicle0.75532484
125MP0002882_abnormal_neuron_morphology0.75463834
126MP0001348_abnormal_lacrimal_gland0.75002300
127MP0003693_abnormal_embryo_hatching0.74134835
128MP0002132_abnormal_respiratory_system0.73885343
129MP0002166_altered_tumor_susceptibility0.73834233
130MP0003172_abnormal_lysosome_physiology0.73648752
131MP0005375_adipose_tissue_phenotype0.72949899
132MP0000313_abnormal_cell_death0.72842854
133MP0002877_abnormal_melanocyte_morpholog0.72279608
134MP0003866_abnormal_defecation0.71721322
135MP0000266_abnormal_heart_morphology0.71204219
136MP0010307_abnormal_tumor_latency0.70118970

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.13759492
2Hyperacusis (HP:0010780)3.78929834
3Heterotopia (HP:0002282)3.09425453
4Astrocytoma (HP:0009592)3.04288249
5Abnormality of the astrocytes (HP:0100707)3.04288249
6Renal duplication (HP:0000075)2.97349928
7Ependymoma (HP:0002888)2.91685335
8Increased nuchal translucency (HP:0010880)2.90516442
9Insomnia (HP:0100785)2.86211955
10Macroorchidism (HP:0000053)2.77190737
11Volvulus (HP:0002580)2.64518771
12Peripheral hypomyelination (HP:0007182)2.61694103
13Short 4th metacarpal (HP:0010044)2.58236776
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58236776
15Bronchomalacia (HP:0002780)2.56327602
16Colon cancer (HP:0003003)2.55263947
17Elfin facies (HP:0004428)2.49876131
18Leiomyosarcoma (HP:0100243)2.48914535
19Uterine leiomyosarcoma (HP:0002891)2.48914535
20Abnormality of the fingertips (HP:0001211)2.45786404
21Overriding aorta (HP:0002623)2.45059819
22Gastrointestinal carcinoma (HP:0002672)2.41587401
23Malignant gastrointestinal tract tumors (HP:0006749)2.41587401
24Metaphyseal cupping (HP:0003021)2.39719911
25Neoplasm of the oral cavity (HP:0100649)2.37305424
26Ankle clonus (HP:0011448)2.36991631
27Pointed chin (HP:0000307)2.35568219
28Deep philtrum (HP:0002002)2.34622576
29High anterior hairline (HP:0009890)2.31894690
30Neonatal short-limb short stature (HP:0008921)2.29095703
31Proximal placement of thumb (HP:0009623)2.27678664
32Neoplasm of the heart (HP:0100544)2.27213085
33Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.26442503
34Transitional cell carcinoma of the bladder (HP:0006740)2.24766776
35Abnormality of the lower motor neuron (HP:0002366)2.23864741
36Deviation of the thumb (HP:0009603)2.22107654
37Amyotrophic lateral sclerosis (HP:0007354)2.19546128
38Deep palmar crease (HP:0006191)2.19182735
39Vertebral arch anomaly (HP:0008438)2.18739342
40Renovascular hypertension (HP:0100817)2.16571171
41Disproportionate tall stature (HP:0001519)2.16416724
42Sparse lateral eyebrow (HP:0005338)2.15563888
43Precocious puberty (HP:0000826)2.15148912
44Bladder neoplasm (HP:0009725)2.14946523
45Bladder carcinoma (HP:0002862)2.14946523
46Insidious onset (HP:0003587)2.14030512
47Termporal pattern (HP:0011008)2.14030512
48Sacral dimple (HP:0000960)2.12937440
49Sleep apnea (HP:0010535)2.12069753
50Rectal prolapse (HP:0002035)2.10764151
51Glioma (HP:0009733)2.10028906
52Hand muscle atrophy (HP:0009130)2.09580517
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.08758610
54Arnold-Chiari malformation (HP:0002308)2.08736547
55Long eyelashes (HP:0000527)2.07399478
56Hammertoe (HP:0001765)2.07226145
57Hepatoblastoma (HP:0002884)2.03869226
58Abnormality of the right ventricle (HP:0001707)2.03326538
59Aqueductal stenosis (HP:0002410)2.03055886
60Abnormality of the 4th metacarpal (HP:0010012)2.03046728
61Cortical dysplasia (HP:0002539)2.02888722
62Trigonocephaly (HP:0000243)2.02725115
63Abnormal hair whorl (HP:0010721)1.99555195
64Obsessive-compulsive behavior (HP:0000722)1.97982644
65Basal cell carcinoma (HP:0002671)1.96825375
66Subacute progressive viral hepatitis (HP:0006572)1.96751943
67Distal upper limb amyotrophy (HP:0007149)1.96293445
68Upper limb amyotrophy (HP:0009129)1.96293445
69Cerebral aneurysm (HP:0004944)1.96058255
70Medulloblastoma (HP:0002885)1.95287452
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93740908
72Ankyloglossia (HP:0010296)1.91450252
73Cutis marmorata (HP:0000965)1.90244940
74Megalencephaly (HP:0001355)1.89575224
75Tracheomalacia (HP:0002779)1.88666190
76Abnormality of the musculature of the hand (HP:0001421)1.88074286
77Centrally nucleated skeletal muscle fibers (HP:0003687)1.88006993
78Bowel incontinence (HP:0002607)1.87530918
79Renal cell carcinoma (HP:0005584)1.87410457
80Supernumerary ribs (HP:0005815)1.87254042
81Increased connective tissue (HP:0009025)1.86886663
82Decreased motor nerve conduction velocity (HP:0003431)1.86148554
83Broad palm (HP:0001169)1.85798103
84Prominent nose (HP:0000448)1.85434204
85Fibroma (HP:0010614)1.84735128
86Hallux valgus (HP:0001822)1.84525642
87Urethral obstruction (HP:0000796)1.83729285
88Fibrous tissue neoplasm (HP:0012316)1.83611541
89Abnormality of the phalanges of the hallux (HP:0010057)1.82581195
90Abnormality of oral frenula (HP:0000190)1.82008453
91Long palpebral fissure (HP:0000637)1.81046204
92Spina bifida occulta (HP:0003298)1.81030938
93Shallow orbits (HP:0000586)1.80660360
94Relative macrocephaly (HP:0004482)1.79188489
95Deviation of the hallux (HP:0010051)1.78696661
96Segmental peripheral demyelination/remyelination (HP:0003481)1.78450081
97Overgrowth (HP:0001548)1.78366855
98Skin tags (HP:0010609)1.77938164
99Slow saccadic eye movements (HP:0000514)1.77612025
100Flat acetabular roof (HP:0003180)1.77258665
101Difficulty running (HP:0009046)1.76725208
102Thin ribs (HP:0000883)1.73966355
103Narrow palate (HP:0000189)1.73232214
104Annular pancreas (HP:0001734)1.72946704
105Bowel diverticulosis (HP:0005222)1.72807162
106Asymmetry of the thorax (HP:0001555)1.72187432
107Spastic gait (HP:0002064)1.72076034
108Turricephaly (HP:0000262)1.71781387
109Split hand (HP:0001171)1.71714555
110Megalocornea (HP:0000485)1.71392991
111Flat cornea (HP:0007720)1.70519650
112Broad thumb (HP:0011304)1.70380403
113Cubitus valgus (HP:0002967)1.69443548
114Genetic anticipation (HP:0003743)1.69122223
115Anal stenosis (HP:0002025)1.68556443
116Pseudobulbar signs (HP:0002200)1.68180677
117Truncal obesity (HP:0001956)1.66986906
118Dysmetric saccades (HP:0000641)1.65403094
119Skull defect (HP:0001362)1.65052400
120Abnormal vertebral ossification (HP:0100569)1.64292995
121Abnormality of the diencephalon (HP:0010662)1.63969169
122Attention deficit hyperactivity disorder (HP:0007018)1.63649987
123Broad face (HP:0000283)1.62504789
124Abnormal large intestine physiology (HP:0012700)1.62062101
125Abnormality of chromosome segregation (HP:0002916)1.61811475
126Smooth philtrum (HP:0000319)1.61200140
127Hypochromic microcytic anemia (HP:0004840)1.60918876
128Absent epiphyses (HP:0010577)1.60157281
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.60157281
130Genu recurvatum (HP:0002816)1.60063733
131Abnormality of the calcaneus (HP:0008364)1.59671726
132Omphalocele (HP:0001539)1.59114637
133Neurofibrillary tangles (HP:0002185)1.58992718
134Neoplasm of striated muscle (HP:0009728)1.58629249
135Apathy (HP:0000741)1.57717758
136Cerebral inclusion bodies (HP:0100314)1.57374364
137Eczematoid dermatitis (HP:0000976)1.56374488
138Supernumerary bones of the axial skeleton (HP:0009144)1.55793866
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55200168
140Abnormality of the salivary glands (HP:0010286)1.55181667
141Anteriorly placed anus (HP:0001545)1.54892698
142Abnormal number of incisors (HP:0011064)1.54784041
143Urinary urgency (HP:0000012)1.54705609
144Germ cell neoplasia (HP:0100728)1.54577450
145Broad phalanges of the hand (HP:0009768)1.54385683
146Patellar dislocation (HP:0002999)1.54347774
147Inappropriate behavior (HP:0000719)1.54154397
148Hemiplegia (HP:0002301)1.54101119
149Onion bulb formation (HP:0003383)1.53253090
150Tented upper lip vermilion (HP:0010804)1.52862918
151Bicuspid aortic valve (HP:0001647)1.52633679
152Mitral valve prolapse (HP:0001634)1.52043961
153Intellectual disability, profound (HP:0002187)1.51796759
154Papillary thyroid carcinoma (HP:0002895)1.51549379
155Supranuclear gaze palsy (HP:0000605)1.51496311
156Short philtrum (HP:0000322)1.51455080
157Limited elbow extension (HP:0001377)1.50895728
158Back pain (HP:0003418)1.50812549
159Pelvic girdle muscle weakness (HP:0003749)1.50101646
160Abnormality of the intervertebral disk (HP:0005108)1.49088132
161Broad finger (HP:0001500)1.49047605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.25742721
2ICK3.79134251
3MAP3K103.60285877
4EEF2K3.19390842
5TRIB32.86658655
6PRPF4B2.41675993
7SMG12.29084966
8SIK22.15549731
9ALK2.09868183
10PKN22.02891199
11BRD41.94682607
12CAMK1G1.92194794
13UHMK11.84779809
14NEK21.80003360
15FGFR41.79622616
16MAP4K11.71884205
17MAP3K91.69065154
18CAMK1D1.67876585
19TYRO31.67675252
20MTOR1.51843722
21GRK61.50428489
22STK101.49386128
23FGFR31.44683901
24PTK61.41314177
25SIK31.28881797
26RIPK41.21914561
27SCYL21.21113637
28YES11.19392401
29TAOK11.18324671
30RPS6KB21.17677055
31PAK61.17060214
32CDC71.16706528
33PDGFRA1.16216619
34LMTK21.15794696
35KSR21.15575290
36SGK31.15175801
37KSR11.14606493
38WNK11.12993715
39FGFR11.10764097
40ERN11.07074069
41RIPK11.05235358
42NTRK11.03330974
43SIK10.99820046
44MARK10.99266225
45MARK20.96623673
46PNCK0.96618505
47BMX0.94828816
48DYRK1B0.94828142
49TNK20.93977362
50BUB10.93366204
51EPHA30.93059984
52SGK20.92856079
53NTRK20.92619342
54CAMKK10.90083650
55MAP3K70.89486961
56LRRK20.88852461
57MATK0.88644032
58PRKD30.88539070
59NTRK30.87991864
60CDK60.87679442
61SGK2230.87300679
62SGK4940.87300679
63CDK190.86556286
64HIPK20.82413745
65CDK40.81815668
66DMPK0.79450677
67CSNK1A1L0.79113219
68PAK20.77951794
69PAK40.76361483
70CHEK10.75660236
71CDK20.72987410
72CDC42BPA0.72941649
73TSSK60.72698498
74RET0.72342588
75STK380.69931372
76MAP3K130.69129046
77MELK0.68973040
78CDK70.68601477
79FGR0.68447303
80FGFR20.68056709
81DYRK30.65683076
82STK110.64782894
83FES0.62222254
84PDGFRB0.62120986
85STK240.61714781
86MAPK90.60893960
87EPHB10.60792249
88MAPK100.60631686
89MAP3K80.60147588
90PRKCH0.60103799
91CLK10.59267452
92IRAK40.57952896
93DYRK1A0.57925653
94LATS20.56789948
95ERBB20.56413752
96AKT20.55365988
97CDK50.54041339
98PRKD20.53808525
99TTN0.53540651
100PTK20.52939919
101MAP3K60.52601273
102CSNK1E0.52334003
103PRKAA10.52298116
104TNIK0.51932298
105MAP3K10.51276875
106MAP3K20.50657834
107MINK10.48923450
108CDK30.48811494
109RAF10.48809346
110CDK11A0.48563521
111LATS10.47938141
112SRPK10.47846765
113CDK10.47049367
114GSK3B0.46064693
115RPS6KA40.45979381
116ATR0.45921499
117ZAP700.45881121
118ROCK20.45665011
119CDK150.45489874
120IRAK20.45282727
121PRKDC0.45163874
122ITK0.45055509
123JAK20.44935907
124MAP2K20.44838960
125CSNK1G20.44653860
126CDK90.44581280
127MAPK80.43748119
128BTK0.43742648
129CSNK1G30.43525213
130MAPK140.43345871
131SGK10.42058106
132CDK180.42004032
133RPS6KA10.41846493
134HCK0.41269612
135PAK30.40878932
136ATM0.39973943
137CSK0.39347765
138MAPK10.39198538
139CAMK40.39153196
140CAMK10.38963439
141EPHB20.38852772
142CDK140.38617536

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.68685055
2Dorso-ventral axis formation_Homo sapiens_hsa043202.06810041
3Notch signaling pathway_Homo sapiens_hsa043301.92665882
4Chronic myeloid leukemia_Homo sapiens_hsa052201.82398729
5Basal cell carcinoma_Homo sapiens_hsa052171.70681065
6Endometrial cancer_Homo sapiens_hsa052131.61447794
7Colorectal cancer_Homo sapiens_hsa052101.61105138
8* mRNA surveillance pathway_Homo sapiens_hsa030151.59435851
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57477432
10mTOR signaling pathway_Homo sapiens_hsa041501.55951939
11Renal cell carcinoma_Homo sapiens_hsa052111.51335109
12B cell receptor signaling pathway_Homo sapiens_hsa046621.49313427
13Neurotrophin signaling pathway_Homo sapiens_hsa047221.41230881
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40815572
15Acute myeloid leukemia_Homo sapiens_hsa052211.39712051
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39618860
17Hedgehog signaling pathway_Homo sapiens_hsa043401.38560045
18Non-small cell lung cancer_Homo sapiens_hsa052231.37965162
19MicroRNAs in cancer_Homo sapiens_hsa052061.37671531
20Glioma_Homo sapiens_hsa052141.35812406
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34672845
22VEGF signaling pathway_Homo sapiens_hsa043701.32743486
23Estrogen signaling pathway_Homo sapiens_hsa049151.32100582
24T cell receptor signaling pathway_Homo sapiens_hsa046601.32034748
25Long-term potentiation_Homo sapiens_hsa047201.29872337
26Spliceosome_Homo sapiens_hsa030401.28927934
27Hippo signaling pathway_Homo sapiens_hsa043901.27681941
28Inositol phosphate metabolism_Homo sapiens_hsa005621.22046003
29Proteoglycans in cancer_Homo sapiens_hsa052051.20860062
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19753751
31ErbB signaling pathway_Homo sapiens_hsa040121.18749202
32Wnt signaling pathway_Homo sapiens_hsa043101.17488874
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16585060
34Adherens junction_Homo sapiens_hsa045201.15511378
35AMPK signaling pathway_Homo sapiens_hsa041521.10582611
36Pancreatic cancer_Homo sapiens_hsa052121.07978153
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07004189
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04046955
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03592976
40Axon guidance_Homo sapiens_hsa043601.02535963
41MAPK signaling pathway_Homo sapiens_hsa040101.00526494
42Type II diabetes mellitus_Homo sapiens_hsa049301.00481298
43Gap junction_Homo sapiens_hsa045401.00316622
44GnRH signaling pathway_Homo sapiens_hsa049120.99802162
45HTLV-I infection_Homo sapiens_hsa051660.97663437
46Prolactin signaling pathway_Homo sapiens_hsa049170.96270430
47Oocyte meiosis_Homo sapiens_hsa041140.95605071
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.94909283
49HIF-1 signaling pathway_Homo sapiens_hsa040660.94094667
50* RNA transport_Homo sapiens_hsa030130.93953325
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93432842
52Lysine degradation_Homo sapiens_hsa003100.92467013
53Pathways in cancer_Homo sapiens_hsa052000.90833789
54Dopaminergic synapse_Homo sapiens_hsa047280.90248222
55Melanogenesis_Homo sapiens_hsa049160.90140467
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.89773725
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89265423
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88435701
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86978854
60Chemokine signaling pathway_Homo sapiens_hsa040620.86922548
61Choline metabolism in cancer_Homo sapiens_hsa052310.86711680
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.86454435
63Bladder cancer_Homo sapiens_hsa052190.86362826
64Small cell lung cancer_Homo sapiens_hsa052220.85623296
65Circadian entrainment_Homo sapiens_hsa047130.85069252
66Platelet activation_Homo sapiens_hsa046110.84886454
67Prostate cancer_Homo sapiens_hsa052150.83914792
68Gastric acid secretion_Homo sapiens_hsa049710.83463164
69Endocytosis_Homo sapiens_hsa041440.82853355
70Rap1 signaling pathway_Homo sapiens_hsa040150.82316181
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82230034
72Oxytocin signaling pathway_Homo sapiens_hsa049210.82220905
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82011475
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80992463
75Cholinergic synapse_Homo sapiens_hsa047250.80582052
76Circadian rhythm_Homo sapiens_hsa047100.80565734
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80530325
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80397632
79Glutamatergic synapse_Homo sapiens_hsa047240.79205632
80Viral myocarditis_Homo sapiens_hsa054160.79157969
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79092894
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78549531
83Focal adhesion_Homo sapiens_hsa045100.78522126
84FoxO signaling pathway_Homo sapiens_hsa040680.78447424
85Osteoclast differentiation_Homo sapiens_hsa043800.75150741
86Shigellosis_Homo sapiens_hsa051310.74402229
87Thyroid cancer_Homo sapiens_hsa052160.74315588
88Cocaine addiction_Homo sapiens_hsa050300.74283423
89Cell cycle_Homo sapiens_hsa041100.73763029
90Long-term depression_Homo sapiens_hsa047300.73287263
91Synaptic vesicle cycle_Homo sapiens_hsa047210.72829731
92Viral carcinogenesis_Homo sapiens_hsa052030.72498513
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71716460
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71508283
95cAMP signaling pathway_Homo sapiens_hsa040240.70730966
96Insulin signaling pathway_Homo sapiens_hsa049100.70357262
97Prion diseases_Homo sapiens_hsa050200.70257164
98Primary immunodeficiency_Homo sapiens_hsa053400.69901695
99Renin secretion_Homo sapiens_hsa049240.69517650
100Hepatitis B_Homo sapiens_hsa051610.69388422
101Ras signaling pathway_Homo sapiens_hsa040140.68376748
102Tight junction_Homo sapiens_hsa045300.68237322
103Amphetamine addiction_Homo sapiens_hsa050310.68033664
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66413308
105Hepatitis C_Homo sapiens_hsa051600.65819263
106Insulin resistance_Homo sapiens_hsa049310.65425121
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63660338
108Glucagon signaling pathway_Homo sapiens_hsa049220.62620309
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62618359
110TGF-beta signaling pathway_Homo sapiens_hsa043500.62438759
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62351222
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.61055816
113Salivary secretion_Homo sapiens_hsa049700.60630658
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59817717
115Measles_Homo sapiens_hsa051620.59613012
116Fatty acid biosynthesis_Homo sapiens_hsa000610.59507359
117Thyroid hormone synthesis_Homo sapiens_hsa049180.59108405
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56716104
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56477192
120Amoebiasis_Homo sapiens_hsa051460.51633703
121Apoptosis_Homo sapiens_hsa042100.51589615

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